-- dump date 20140619_034209 -- class Genbank::misc_feature -- table misc_feature_note -- id note 471473000001 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 471473000002 dimer interface [polypeptide binding]; other site 471473000003 active site 471473000004 aspartate-rich active site metal binding site; other site 471473000005 allosteric magnesium binding site [ion binding]; other site 471473000006 Schiff base residues; other site 471473000007 PS00169 Delta-aminolevulinic acid dehydratase active site 471473000008 NADH:ubiquinone oxidoreductase, Na(+)-translocating, A subunit; Region: nqrA; TIGR01936 471473000009 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 471473000010 lipoyl-biotinyl attachment site [posttranslational modification]; other site 471473000011 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 471473000012 Putative bacteriophage terminase small subunit; Region: Phage_term_sma; pfam07141 471473000013 transcript cleavage factor/unknown domain fusion protein; Validated; Region: PRK06330 471473000014 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 471473000015 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 471473000016 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 471473000017 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471473000018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471473000019 homodimer interface [polypeptide binding]; other site 471473000020 catalytic residue [active] 471473000021 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site 471473000022 rod shape-determining protein MreC; Provisional; Region: PRK14872 471473000023 rod shape-determining protein MreC; Region: MreC; pfam04085 471473000024 1 probable transmembrane helix predicted for CTL0006 by TMHMM2.0 at aa 13-30 471473000025 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 471473000026 Part of AAA domain; Region: AAA_19; pfam13245 471473000027 Family description; Region: UvrD_C_2; pfam13538 471473000028 PS00017 ATP/GTP-binding site motif A (P-loop) 471473000029 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 471473000030 lysophospholipid transporter LplT; Provisional; Region: PRK11195 471473000031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471473000032 putative substrate translocation pore; other site 471473000033 12 probable transmembrane helices predicted for CTL0009 by TMHMM2.0 at aa 13-35, 48-70, 77-99,105-127,140-162, 172-194, 227-249, 264-286, 291-313,318-340,353-375 and 385-404 471473000034 1 probable transmembrane helix predicted for CTL0010 by TMHMM2.0 at aa 182-204 471473000035 DNA topoisomerase I/SWI domain fusion protein; Validated; Region: PRK06319 471473000036 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 471473000037 active site 471473000038 interdomain interaction site; other site 471473000039 putative metal-binding site [ion binding]; other site 471473000040 nucleotide binding site [chemical binding]; other site 471473000041 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 471473000042 domain I; other site 471473000043 DNA binding groove [nucleotide binding] 471473000044 phosphate binding site [ion binding]; other site 471473000045 domain II; other site 471473000046 domain III; other site 471473000047 nucleotide binding site [chemical binding]; other site 471473000048 catalytic site [active] 471473000049 domain IV; other site 471473000050 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 471473000051 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 471473000052 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 471473000053 SWI complex, BAF60b domains; Region: SWIB; smart00151 471473000054 PS00396 Prokaryotic DNA topoisomerase I active site 471473000055 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 471473000056 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 471473000057 FMN binding site [chemical binding]; other site 471473000058 active site 471473000059 catalytic residues [active] 471473000060 substrate binding site [chemical binding]; other site 471473000061 PS01136 Uncharacterized protein family UPF0034 signature 471473000062 Predicted integral membrane protein [Function unknown]; Region: COG0762 471473000063 2 probable transmembrane helices predicted for CTL0013 by TMHMM2.0 at aa 4-26 and 64-86 471473000064 1 probable transmembrane helix predicted for CTL0015 by TMHMM2.0 at aa 5-27 471473000065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 471473000066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 471473000067 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 471473000068 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 471473000069 recombinase A; Provisional; Region: recA; PRK09354 471473000070 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 471473000071 hexamer interface [polypeptide binding]; other site 471473000072 Walker A motif; other site 471473000073 ATP binding site [chemical binding]; other site 471473000074 Walker B motif; other site 471473000075 PS00017 ATP/GTP-binding site motif A (P-loop) 471473000076 PS00321 recA signature 471473000077 Protein of unknown function (DUF1347); Region: DUF1347; pfam07079 471473000078 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 471473000079 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 471473000080 AAA domain; Region: AAA_30; pfam13604 471473000081 Family description; Region: UvrD_C_2; pfam13538 471473000082 PS00017 ATP/GTP-binding site motif A (P-loop) 471473000083 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 471473000084 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 471473000085 Walker A/P-loop; other site 471473000086 ATP binding site [chemical binding]; other site 471473000087 Q-loop/lid; other site 471473000088 ABC transporter signature motif; other site 471473000089 Walker B; other site 471473000090 D-loop; other site 471473000091 H-loop/switch region; other site 471473000092 PS00211 ABC transporters family signature 471473000093 PS00017 ATP/GTP-binding site motif A (P-loop) 471473000094 Protein of unknown function (DUF1137); Region: DUF1137; pfam06587 471473000095 1 probable transmembrane helix predicted for CTL0023 by TMHMM2.0 at aa 5-27 471473000096 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 471473000097 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; COG2877 471473000098 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 471473000099 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 471473000100 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471473000101 RNA binding surface [nucleotide binding]; other site 471473000102 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 471473000103 active site 471473000104 hypothetical protein; Provisional; Region: PRK01064 471473000105 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 471473000106 DNA topoisomerase IV subunit A; Provisional; Region: PRK09630 471473000107 DNA Topoisomerase IV; Region: TOP4c; smart00434 471473000108 CAP-like domain; other site 471473000109 active site 471473000110 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 471473000111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471473000112 ATP binding site [chemical binding]; other site 471473000113 Mg2+ binding site [ion binding]; other site 471473000114 G-X-G motif; other site 471473000115 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 471473000116 ATP binding site [chemical binding]; other site 471473000117 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 471473000118 active site 471473000119 putative metal-binding site [ion binding]; other site 471473000120 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 471473000121 glutamyl-tRNA reductase; Validated; Region: hemA; PRK00676 471473000122 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 471473000123 NAD(P) binding pocket [chemical binding]; other site 471473000124 HMMPfam hit to PF05201, Glutamyl-tRNAGlu reductase,N-terminal domai, score 3.9e-54 471473000125 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 471473000126 HMMPfam hit to PF05932, Tir chaperone protein (CesT), score 8.1e-35 471473000127 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471473000128 phosphopeptide binding site; other site 471473000129 MARCKS family; Region: MARCKS; pfam02063 471473000130 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471473000131 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 471473000132 phosphopeptide binding site; other site 471473000133 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 471473000134 HMMPfam hit to PF00498, FHA domain, score 6.6e-11 471473000135 HMMPfam hit to PF00498, FHA domain, score 9e-11 471473000136 1 probable transmembrane helix predicted for CTL0033 by TMHMM2.0 at aa 530-552 471473000137 HMMPfam hit to PF04972, Putative phospholipid-binding domain, score 3.3e-10 471473000138 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 471473000139 binding surface 471473000140 Tetratricopeptide repeat; Region: TPR_16; pfam13432 471473000141 TPR motif; other site 471473000142 HMMPfam hit to PF07719, Tetratricopeptide repeat,score 0.0037 471473000143 type III secretion system ATPase; Provisional; Region: PRK06315 471473000144 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 471473000145 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 471473000146 Walker A motif/ATP binding site; other site 471473000147 Walker B motif; other site 471473000148 HMMPfam hit to PF02874, ATP synthase alpha/beta family, beta-ba, score 9.6e-07 471473000149 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleot, score 9.1e-125 471473000150 PS00017 ATP/GTP-binding site motif A (P-loop) 471473000151 PS00152 ATP synthase alpha and beta subunits signature 471473000152 type III secretion system protein; Validated; Region: PRK05933 471473000153 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 471473000154 HMMPfam hit to PF01052, Surface presentation of antigens (SPOA) prot, score 0.00025 471473000155 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471473000156 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471473000157 active site 471473000158 ATP binding site [chemical binding]; other site 471473000159 substrate binding site [chemical binding]; other site 471473000160 activation loop (A-loop); other site 471473000161 HMMPfam hit to PF00069, Protein kinase domain,score 6.6e-29 471473000162 PS00108 Serine/Threonine protein kinases active-site signature 471473000163 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 471473000164 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 471473000165 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 471473000166 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 471473000167 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 2.5e-09 471473000168 PS00591 Glycosyl hydrolases family 10 active site 471473000169 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 2.8e-09 471473000170 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 3.2e-09 471473000171 HMMPfam hit to PF00263, Bacterial type II and III secretion system, score 2.8e-72 471473000172 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 471473000173 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 471473000174 ADP binding site [chemical binding]; other site 471473000175 phosphagen binding site; other site 471473000176 substrate specificity loop; other site 471473000177 HMMPfam hit to PF00217, ATP:guanido phosphotransferase, C-term, score 9.2e-05 471473000178 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 471473000179 UvrB/uvrC motif; Region: UVR; pfam02151 471473000180 HMMPfam hit to PF02151, UvrB/uvrC motif, score 4.9e-09 471473000181 ribosome recycling factor; Reviewed; Region: frr; PRK00083 471473000182 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 471473000183 hinge region; other site 471473000184 HMMPfam hit to PF01765, Ribosome recycling factor,score 4.1e-85 471473000185 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 471473000186 putative nucleotide binding site [chemical binding]; other site 471473000187 uridine monophosphate binding site [chemical binding]; other site 471473000188 homohexameric interface [polypeptide binding]; other site 471473000189 HMMPfam hit to PF00696, Amino acid kinase family,score 2.3e-51 471473000190 Translation elongation factor Ts [Translation, ribosomal structure and biogenesis]; Region: Tsf; COG0264 471473000191 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 471473000192 Elongation factor TS; Region: EF_TS; pfam00889 471473000193 Elongation factor TS; Region: EF_TS; pfam00889 471473000194 HMMPfam hit to PF00889, Elongation factor TS, score 9.6e-105 471473000195 PS01127 Elongation factor Ts signature 2 471473000196 HMMPfam hit to PF00627, UBA/TS-N domain, score 9.2e-09 471473000197 PS01126 Elongation factor Ts signature 1 471473000198 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 471473000199 rRNA interaction site [nucleotide binding]; other site 471473000200 S8 interaction site; other site 471473000201 putative laminin-1 binding site; other site 471473000202 HMMPfam hit to PF00318, Ribosomal protein S2, score 1.2e-84 471473000203 PS00963 Ribosomal protein S2 signature 2 471473000204 PS00962 Ribosomal protein S2 signature 1 471473000205 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 471473000206 HMMPfam hit to PF01308, Chlamydia major outer membrane protein, score 8.2e-268 471473000207 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 471473000208 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 471473000209 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 471473000210 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 471473000211 1 probable transmembrane helix predicted for CTL0051 by TMHMM2.0 at aa 17-39 471473000212 HMMPfam hit to PF03717, Penicillin-binding Protein dimerisatio, score 3e-52 471473000213 HMMPfam hit to PF00905, Penicillin binding protein transpeptid, score 4.6e-06 471473000214 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471473000215 TPR motif; other site 471473000216 Tetratricopeptide repeat; Region: TPR_16; pfam13432 471473000217 binding surface 471473000218 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471473000219 binding surface 471473000220 TPR motif; other site 471473000221 TPR repeat; Region: TPR_11; pfam13414 471473000222 TPR repeat; Region: TPR_11; pfam13414 471473000223 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471473000224 binding surface 471473000225 TPR motif; other site 471473000226 TPR repeat; Region: TPR_11; pfam13414 471473000227 HMMPfam hit to PF07719, Tetratricopeptide repeat,score 0.0015 471473000228 HMMPfam hit to PF00515, Tetratricopeptide repeat,score 7.9e-07 471473000229 HMMPfam hit to PF00515, Tetratricopeptide repeat,score 0.059 471473000230 HMMPfam hit to PF07719, Tetratricopeptide repeat,score 0.00011 471473000231 HMMPfam hit to PF00515, Tetratricopeptide repeat,score 3e-06 471473000232 HMMPfam hit to PF00515, Tetratricopeptide repeat,score 2.5e-05 471473000233 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 471473000234 putative ABC transporter; Region: ycf24; CHL00085 471473000235 HMMPfam hit to PF01458, Uncharacterized protein family (UPF0051), score 6.4e-117 471473000236 FeS assembly ATPase SufC; Region: sufC; TIGR01978 471473000237 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 471473000238 Walker A/P-loop; other site 471473000239 ATP binding site [chemical binding]; other site 471473000240 Q-loop/lid; other site 471473000241 ABC transporter signature motif; other site 471473000242 Walker B; other site 471473000243 D-loop; other site 471473000244 H-loop/switch region; other site 471473000245 HMMPfam hit to PF00005, ABC transporter, score 6.5e-25 471473000246 PS00017 ATP/GTP-binding site motif A (P-loop) 471473000247 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 471473000248 FeS assembly protein SufD; Region: sufD; TIGR01981 471473000249 HMMPfam hit to PF01458, Uncharacterized protein family (UPF0051), score 1.3e-10 471473000250 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 471473000251 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 471473000252 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471473000253 catalytic residue [active] 471473000254 HMMPfam hit to PF00266, Aminotransferase class-V,score 3.2e-197 471473000255 HMMPfam hit to PF01212, Beta-eliminating lyase,score 0.0031 471473000256 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site 471473000257 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 471473000258 ParB-like nuclease domain; Region: ParBc; pfam02195 471473000259 KorB domain; Region: KorB; pfam08535 471473000260 HMMPfam hit to PF02195, ParB-like nuclease domain,score 9.8e-36 471473000261 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471473000262 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 471473000263 Walker A/P-loop; other site 471473000264 ATP binding site [chemical binding]; other site 471473000265 Q-loop/lid; other site 471473000266 ABC transporter signature motif; other site 471473000267 Walker B; other site 471473000268 D-loop; other site 471473000269 H-loop/switch region; other site 471473000270 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471473000271 HMMPfam hit to PF00005, ABC transporter, score 6.5e-46 471473000272 PS00211 ABC transporters family signature 471473000273 PS00017 ATP/GTP-binding site motif A (P-loop) 471473000274 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 471473000275 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471473000276 Walker A/P-loop; other site 471473000277 ATP binding site [chemical binding]; other site 471473000278 Q-loop/lid; other site 471473000279 ABC transporter signature motif; other site 471473000280 Walker B; other site 471473000281 D-loop; other site 471473000282 H-loop/switch region; other site 471473000283 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471473000284 HMMPfam hit to PF08352, Oligopeptide/dipeptide transporter, C-termi, score 5.8e-21 471473000285 HMMPfam hit to PF00005, ABC transporter, score 2.2e-50 471473000286 PS00211 ABC transporters family signature 471473000287 PS00017 ATP/GTP-binding site motif A (P-loop) 471473000288 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 471473000289 HMMPfam hit to PF01865, Protein of unknown function DUF47, score 3.3e-111 471473000290 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 471473000291 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 471473000292 10 probable transmembrane helices predicted for CTL0061 by TMHMM2.0 at aa 2-21, 36-58, 101-123,138-160,181-203, 208-230, 260-282, 310-332, 362-384 and 399-421 471473000293 HMMPfam hit to PF01384, Phosphate transporter family, score 8.1e-191 471473000294 PS00211 ABC transporters family signature 471473000295 Phosphoglycerate kinase; Region: PGK; pfam00162 471473000296 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 471473000297 substrate binding site [chemical binding]; other site 471473000298 hinge regions; other site 471473000299 ADP binding site [chemical binding]; other site 471473000300 catalytic site [active] 471473000301 HMMPfam hit to PF00162, Phosphoglycerate kinase,score 8.8e-182 471473000302 PS00111 Phosphoglycerate kinase signature 471473000303 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 471473000304 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 471473000305 minor groove reading motif; other site 471473000306 helix-hairpin-helix signature motif; other site 471473000307 substrate binding pocket [chemical binding]; other site 471473000308 active site 471473000309 HMMPfam hit to PF00730, HhH-GPD superfamily base excision DNA repair, score 8.2e-22 471473000310 HMMPfam hit to PF00633, Helix-hairpin-helix motif,score 2.1e-05 471473000311 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 471473000312 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 471473000313 trmE is a tRNA modification GTPase; Region: trmE; cd04164 471473000314 G1 box; other site 471473000315 GTP/Mg2+ binding site [chemical binding]; other site 471473000316 Switch I region; other site 471473000317 G2 box; other site 471473000318 Switch II region; other site 471473000319 G3 box; other site 471473000320 G4 box; other site 471473000321 G5 box; other site 471473000322 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 471473000323 HMMPfam hit to PF01926, GTPase of unknown function,score 3e-41 471473000324 PS00017 ATP/GTP-binding site motif A (P-loop) 471473000325 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 471473000326 HMMPfam hit to PF02666, Phosphatidylserine decarboxylase, score 1e-113 471473000327 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471473000328 binding surface 471473000329 TPR motif; other site 471473000330 1 probable transmembrane helix predicted for CTL0069 by TMHMM2.0 at aa 2-19 471473000331 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 471473000332 HMMPfam hit to PF07719, Tetratricopeptide repeat,score 0.00073 471473000333 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12899 471473000334 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 471473000335 ATP binding site [chemical binding]; other site 471473000336 putative Mg++ binding site [ion binding]; other site 471473000337 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 471473000338 HMMPfam hit to PF07517, SecA DEAD-like domain,score 6.2e-162 471473000339 HMMPfam hit to PF01043, SecA preprotein cross-linking domain, score 4.5e-16 471473000340 PS01312 Protein secA signatures 471473000341 HMMPfam hit to PF07516, SecA Wing and Scaffold domain, score 8.5e-42 471473000342 Predicted GTPases [General function prediction only]; Region: COG1160 471473000343 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 471473000344 G1 box; other site 471473000345 GTP/Mg2+ binding site [chemical binding]; other site 471473000346 Switch I region; other site 471473000347 G2 box; other site 471473000348 Switch II region; other site 471473000349 G3 box; other site 471473000350 G4 box; other site 471473000351 G5 box; other site 471473000352 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 471473000353 G1 box; other site 471473000354 GTP/Mg2+ binding site [chemical binding]; other site 471473000355 Switch I region; other site 471473000356 G2 box; other site 471473000357 G3 box; other site 471473000358 Switch II region; other site 471473000359 G4 box; other site 471473000360 G5 box; other site 471473000361 HMMPfam hit to PF01926, GTPase of unknown function,score 8.5e-45 471473000362 PS00017 ATP/GTP-binding site motif A (P-loop) 471473000363 HMMPfam hit to PF01926, GTPase of unknown function,score 4.3e-41 471473000364 PS00017 ATP/GTP-binding site motif A (P-loop) 471473000365 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 471473000366 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 471473000367 active site 471473000368 NTP binding site [chemical binding]; other site 471473000369 metal binding triad [ion binding]; metal-binding site 471473000370 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 471473000371 HMMPfam hit to PF01743, Poly A polymerase family,score 3.1e-78 471473000372 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 471473000373 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 471473000374 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471473000375 Walker A motif; other site 471473000376 ATP binding site [chemical binding]; other site 471473000377 Walker B motif; other site 471473000378 arginine finger; other site 471473000379 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 471473000380 HMMPfam hit to PF00004, ATPase family associated with various cell, score 1.3e-05 471473000381 HMMPfam hit to PF07724, ATPase family associated with various cell, score 1e-79 471473000382 PS00017 ATP/GTP-binding site motif A (P-loop) 471473000383 HMMPfam hit to PF06689, ClpX C4-type zinc finger,score 1.6e-21 471473000384 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 471473000385 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 471473000386 oligomer interface [polypeptide binding]; other site 471473000387 active site residues [active] 471473000388 HMMPfam hit to PF00574, Clp protease, score 1.7e-117 471473000389 PS00382 Endopeptidase Clp histidine active site 471473000390 PS00381 Endopeptidase Clp serine active site 471473000391 PS00225 Crystallins beta and gamma 'Greek key' motif signature 471473000392 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]; Region: Tig; COG0544 471473000393 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 471473000394 HMMPfam hit to PF05698, Bacterial trigger factor protein (TF) C-ter, score 6.1e-35 471473000395 HMMPfam hit to PF05697, Bacterial trigger factor protein (TF), score 1e-38 471473000396 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 471473000397 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 471473000398 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471473000399 ATP binding site [chemical binding]; other site 471473000400 putative Mg++ binding site [ion binding]; other site 471473000401 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471473000402 nucleotide binding region [chemical binding]; other site 471473000403 ATP-binding site [chemical binding]; other site 471473000404 HMMPfam hit to PF04434, SWIM zinc finger, score 3.8e-07 471473000405 HMMPfam hit to PF04851, Type III restriction enzyme,res subunit, score 1.7e-05 471473000406 HMMPfam hit to PF00176, SNF2 family N-terminal domain, score 5.5e-87 471473000407 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 1.2e-26 471473000408 rod shape-determining protein MreB; Provisional; Region: PRK13927 471473000409 MreB and similar proteins; Region: MreB_like; cd10225 471473000410 nucleotide binding site [chemical binding]; other site 471473000411 Mg binding site [ion binding]; other site 471473000412 putative protofilament interaction site [polypeptide binding]; other site 471473000413 RodZ interaction site [polypeptide binding]; other site 471473000414 HMMPfam hit to PF06723, MreB/Mbl protein, score 1.1e-229 471473000415 PS00017 ATP/GTP-binding site motif A (P-loop) 471473000416 HMMPfam hit to PF02491, Cell division protein FtsA,score 0.00014 471473000417 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 471473000418 active site 471473000419 substrate-binding site [chemical binding]; other site 471473000420 metal-binding site [ion binding] 471473000421 GTP binding site [chemical binding]; other site 471473000422 HMMPfam hit to PF00821, Phosphoenolpyruvate carboxykinase, score 0 471473000423 PS00505 Phosphoenolpyruvate carboxykinase (GTP) signature 471473000424 PS00012 Phosphopantetheine attachment site 471473000425 Effector from type III secretion system; Region: Effector_1; pfam04518 471473000426 HMMPfam hit to PF04518, Protein of unknown function,DUF582, score 8.8e-200 471473000427 Effector from type III secretion system; Region: Effector_1; pfam04518 471473000428 HMMPfam hit to PF04518, Protein of unknown function,DUF582, score 2.5e-192 471473000429 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 471473000430 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 471473000431 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 471473000432 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 471473000433 HMMPfam hit to PF07479, NAD-dependent glycerol-3-phosphate deh, score 5e-81 471473000434 HMMPfam hit to PF01210, NAD-dependent glycerol-3-phosphate deh, score 1.1e-65 471473000435 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 471473000436 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471473000437 active site 471473000438 HMMPfam hit to PF01704, UTP--glucose-1-phosphate uridylyltransferase, score 8.9e-08 471473000439 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 471473000440 type III secretion system ATPase; Validated; Region: PRK05922 471473000441 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 471473000442 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 471473000443 Walker A motif; other site 471473000444 ATP binding site [chemical binding]; other site 471473000445 Walker B motif; other site 471473000446 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleot, score 5.2e-89 471473000447 PS00152 ATP synthase alpha and beta subunits signature 471473000448 HMMPfam hit to PF02874, ATP synthase alpha/beta family, beta-ba, score 0.00025 471473000449 type III secretion system protein; Validated; Region: PRK05934 471473000450 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 471473000451 1 probable transmembrane helix predicted for CTL0088 by TMHMM2.0 at aa 247-269 471473000452 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 471473000453 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 471473000454 active site 471473000455 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 471473000456 HMMPfam hit to PF01106, NifU-like domain, score 9.3e-05 471473000457 HMMPfam hit to PF01592, NifU-like N terminal domain,score 1.3e-06 471473000458 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 471473000459 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471473000460 catalytic residue [active] 471473000461 HMMPfam hit to PF00266, Aminotransferase class-V,score 4.5e-07 471473000462 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471473000463 catalytic core [active] 471473000464 HMMPfam hit to PF00300, Phosphoglycerate mutase family, score 1.4e-38 471473000465 PS00175 Phosphoglycerate mutase family phosphohistidine signature 471473000466 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 471473000467 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471473000468 RNA binding surface [nucleotide binding]; other site 471473000469 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 471473000470 active site 471473000471 PS00430 TonB-dependent receptor proteins signature 1 471473000472 HMMPfam hit to PF01479, S4 domain, score 2.8e-09 471473000473 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 1e-30 471473000474 PS01149 Rsu family of pseudouridine synthase signature 471473000475 biotin--protein ligase; Provisional; Region: PRK05935 471473000476 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 471473000477 HMMPfam hit to PF03099, Biotin/lipoate A/B protein ligase famil, score 2.1e-23 471473000478 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 471473000479 HMMPfam hit to PF01098, Cell cycle protein, score 2.2e-48 471473000480 8 probable transmembrane helices predicted for CTL0095 by TMHMM2.0 at aa 12-29, 77-99, 144-161,166-185,192-214, 279-301, 314-336 and 346-368 471473000481 PS00012 Phosphopantetheine attachment site 471473000482 PS00428 Cell cycle proteins ftsW / rodA / spoVE signature 471473000483 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 471473000484 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471473000485 Soluble P-type ATPase [General function prediction only]; Region: COG4087 471473000486 7 probable transmembrane helices predicted for CTL0096 by TMHMM2.0 at aa 46-65, 67-86, 106-128,267-289,304-326, 608-627 and 631-653 471473000487 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 3.1e-33 471473000488 PS01229 Hypothetical cof family signature 2 471473000489 PS00154 E1-E2 ATPases phosphorylation site 471473000490 HMMPfam hit to PF00122, E1-E2 ATPase, score 1.6e-50 471473000491 CCC1-related protein family; Region: CCC1_like_1; cd02437 471473000492 3 probable transmembrane helices predicted for CTL0097 by TMHMM2.0 at aa 63-85, 181-203 and 223-245 471473000493 seryl-tRNA synthetase; Provisional; Region: PRK05431 471473000494 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 471473000495 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 471473000496 dimer interface [polypeptide binding]; other site 471473000497 active site 471473000498 motif 1; other site 471473000499 motif 2; other site 471473000500 motif 3; other site 471473000501 HMMPfam hit to PF00587, tRNA synthetase class II core domain (G,, score 2.4e-62 471473000502 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1 471473000503 HMMPfam hit to PF02403, Seryl-tRNA synthetase N-terminal domain, score 7.6e-33 471473000504 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 471473000505 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 471473000506 catalytic motif [active] 471473000507 Zn binding site [ion binding]; other site 471473000508 RibD C-terminal domain; Region: RibD_C; pfam01872 471473000509 HMMPfam hit to PF00383, Cytidine and deoxycytidylate deaminas, score 2.9e-40 471473000510 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature 471473000511 HMMPfam hit to PF01872, RibD C-terminal domain,score 4.4e-95 471473000512 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 471473000513 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 471473000514 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 471473000515 dimerization interface [polypeptide binding]; other site 471473000516 active site 471473000517 PS00430 TonB-dependent receptor proteins signature 1 471473000518 HMMPfam hit to PF00926, 3,4-dihydroxy-2-butanone 4-phosphate, score 1.6e-97 471473000519 HMMPfam hit to PF00925, GTP cyclohydrolase II,score 6.4e-98 471473000520 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 471473000521 homopentamer interface [polypeptide binding]; other site 471473000522 active site 471473000523 HMMPfam hit to PF00885,6,7-dimethyl-8-ribityllumazine synthase, score 3.4e-40 471473000524 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 471473000525 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 471473000526 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 471473000527 11 probable transmembrane helices predicted for CTL0104 by TMHMM2.0 at aa 10-32, 67-89, 94-116,146-168,183-205, 212-229, 239-261, 300-322, 342-364,385-407 and 412-434 471473000528 HMMPfam hit to PF01235, Sodium:alanine symporter family, score 1.2e-18 471473000529 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 471473000530 substrate binding site [chemical binding]; other site 471473000531 HMMPfam hit to PF01161,Phosphatidylethanolamine-binding protein, score 1.6e-58 471473000532 Proteins containing SET domain [General function prediction only]; Region: COG2940 471473000533 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 471473000534 HMMPfam hit to PF00856, SET domain, score 1.7e-35 471473000535 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 471473000536 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 9.8e-15 471473000537 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 471473000538 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 471473000539 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 471473000540 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 471473000541 HMMPfam hit to PF01580, FtsK/SpoIIIE family, score 1.5e-61 471473000542 PS00017 ATP/GTP-binding site motif A (P-loop) 471473000543 5 probable transmembrane helices predicted for CTL0108 by TMHMM2.0 at aa 17-39, 49-71, 91-113, 128-150 and 159-181 471473000544 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF [Energy production and conversion]; Region: NqrF; COG2871 471473000545 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471473000546 catalytic loop [active] 471473000547 iron binding site [ion binding]; other site 471473000548 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 471473000549 FAD binding pocket [chemical binding]; other site 471473000550 FAD binding motif [chemical binding]; other site 471473000551 phosphate binding motif [ion binding]; other site 471473000552 beta-alpha-beta structure motif; other site 471473000553 NAD binding pocket [chemical binding]; other site 471473000554 HMMPfam hit to PF00175, Oxidoreductase NAD-binding domain, score 0.00069 471473000555 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding doma, score 7.4e-12 471473000556 1 probable transmembrane helix predicted for CTL0109 by TMHMM2.0 at aa 7-29 471473000557 preprotein translocase, YajC subunit; Region: yajC; TIGR00739 471473000558 HMMPfam hit to PF02699, Preprotein translocase subunit, score 4e-40 471473000559 2 probable transmembrane helices predicted for CTL0110 by TMHMM2.0 at aa 2-21 and 31-50 471473000560 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 471473000561 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 471473000562 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471473000563 S-adenosylmethionine binding site [chemical binding]; other site 471473000564 HMMPfam hit to PF05958, tRNA (Uracil-5-)-methyltransferase, score 2.8e-08 471473000565 PS01231 RNA methyltransferase trmA family signature 2 471473000566 PS01230 RNA methyltransferase trmA family signature 1 471473000567 Histone H1-like protein Hc1; Region: Hc1; pfam07432 471473000568 HMMPfam hit to PF07432, Histone H1-like protein Hc1,score 4.7e-78 471473000569 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471473000570 binding surface 471473000571 TPR motif; other site 471473000572 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471473000573 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 471473000574 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471473000575 HMMPfam hit to PF01593, Flavin containing amine oxidoreductase, score 0.00038 471473000576 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 0.0012 471473000577 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 471473000578 HemN C-terminal domain; Region: HemN_C; pfam06969 471473000579 HMMPfam hit to PF06969, HemN C-terminal region,score 1.9e-46 471473000580 HMMPfam hit to PF04055, Radical SAM superfamily,score 2e-21 471473000581 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 471473000582 substrate binding site [chemical binding]; other site 471473000583 active site 471473000584 HMMPfam hit to PF01208, Uroporphyrinogen decarboxylase (URO-D), score 1.6e-46 471473000585 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 471473000586 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 471473000587 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471473000588 ATP binding site [chemical binding]; other site 471473000589 putative Mg++ binding site [ion binding]; other site 471473000590 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471473000591 nucleotide binding region [chemical binding]; other site 471473000592 ATP-binding site [chemical binding]; other site 471473000593 TRCF domain; Region: TRCF; pfam03461 471473000594 HMMPfam hit to PF03461, TRCF domain, score 4.3e-43 471473000595 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 4.7e-17 471473000596 HMMPfam hit to PF00270, DEAD/DEAH box helicase,score 1e-32 471473000597 PS00017 ATP/GTP-binding site motif A (P-loop) 471473000598 HMMPfam hit to PF02559, CarD-like/TRCF domain,score 3e-35 471473000599 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 471473000600 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 471473000601 motif 1; other site 471473000602 active site 471473000603 motif 2; other site 471473000604 motif 3; other site 471473000605 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 471473000606 DHHA1 domain; Region: DHHA1; pfam02272 471473000607 HMMPfam hit to PF02272, DHHA1 domain, score 1.4e-12 471473000608 HMMPfam hit to PF07973, Threonyl and Alanyl tRNA synthetase seco, score 6.5e-17 471473000609 HMMPfam hit to PF01411, tRNA synthetases class II (A), score 0 471473000610 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2 471473000611 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 471473000612 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 471473000613 TPP-binding site [chemical binding]; other site 471473000614 dimer interface [polypeptide binding]; other site 471473000615 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 471473000616 PYR/PP interface [polypeptide binding]; other site 471473000617 dimer interface [polypeptide binding]; other site 471473000618 TPP binding site [chemical binding]; other site 471473000619 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471473000620 HMMPfam hit to PF00456, Transketolase, thiamine diphosphate b, score 1.3e-154 471473000621 HMMPfam hit to PF02779, Transketolase, pyridine binding domai, score 1.9e-64 471473000622 PS00213 Lipocalin signature 471473000623 HMMPfam hit to PF02780, Transketolase, C-terminal domain, score 0.0009 471473000624 AMP nucleosidase, putative; Region: AMN-like; TIGR01721 471473000625 HMMPfam hit to PF01048, Phosphorylase family, score 7.4e-08 471473000626 elongation factor P; Validated; Region: PRK00529 471473000627 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 471473000628 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 471473000629 RNA binding site [nucleotide binding]; other site 471473000630 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 471473000631 RNA binding site [nucleotide binding]; other site 471473000632 HMMPfam hit to PF08207, Elongation factor P (EF-P) KOW-like domain, score 1.2e-18 471473000633 HMMPfam hit to PF01132, Elongation factor P (EF-P) OB domain, score 3.8e-05 471473000634 PS01275 Elongation factor P signature 471473000635 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471473000636 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 471473000637 putative active site [active] 471473000638 putative metal binding site [ion binding]; other site 471473000639 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471473000640 active site 471473000641 metal binding site [ion binding]; metal-binding site 471473000642 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 7.8e-17 471473000643 Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459 471473000644 HMMPfam hit to PF00118, TCP-1/cpn60 chaperonin family, score 1.5e-21 471473000645 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 471473000646 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 471473000647 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471473000648 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471473000649 HMMPfam hit to PF01225, Mur ligase family,catalytic domain, score 5.5e-16 471473000650 HMMPfam hit to PF08245, Mur ligase middle domain,score 8.6e-17 471473000651 HMMPfam hit to PF02875, Mur ligase family,glutamate ligase doma, score 6.9e-09 471473000652 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 471473000653 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 471473000654 Mg++ binding site [ion binding]; other site 471473000655 putative catalytic motif [active] 471473000656 putative substrate binding site [chemical binding]; other site 471473000657 10 probable transmembrane helices predicted for CTL0126 by TMHMM2.0 at aa 10-29, 54-76, 80-99,119-137,157-179, 184-206, 210-232, 239-261, 265-287 and 313-335 471473000658 HMMPfam hit to PF00953, Glycosyl transferase family,score 3.2e-40 471473000659 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00683 471473000660 TrkA-N domain; Region: TrkA_N; pfam02254 471473000661 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471473000662 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471473000663 HMMPfam hit to PF08245, Mur ligase middle domain,score 3e-23 471473000664 HMMPfam hit to PF02875, Mur ligase family,glutamate ligase doma, score 1.2e-12 471473000665 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 471473000666 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471473000667 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471473000668 1 probable transmembrane helix predicted for CTL0128 by TMHMM2.0 at aa 7-25 471473000669 HMMPfam hit to PF01476, LysM domain, score 1e-16 471473000670 HMMPfam hit to PF01476, LysM domain, score 3.2e-13 471473000671 cell division protein FtsW; Region: ftsW; TIGR02614 471473000672 HMMPfam hit to PF01098, Cell cycle protein, score 8e-79 471473000673 9 probable transmembrane helices predicted for CTL0129 by TMHMM2.0 at aa 4-21, 41-63, 73-92,137-154,159-176, 181-203, 267-289, 296-318 and 333-355 471473000674 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 471473000675 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 471473000676 active site 471473000677 homodimer interface [polypeptide binding]; other site 471473000678 HMMPfam hit to PF03033, Glycosyltransferase family,score 2.3e-42 471473000679 1 probable transmembrane helix predicted for CTL0130 by TMHMM2.0 at aa 7-29 471473000680 HMMPfam hit to PF04101, Glycosyltransferase family,score 4.3e-54 471473000681 bifunctional D-alanyl-alanine synthetase A/UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: PRK14573 471473000682 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 471473000683 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471473000684 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471473000685 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 471473000686 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 471473000687 1 probable transmembrane helix predicted for CTL0131 by TMHMM2.0 at aa 5-24 471473000688 HMMPfam hit to PF01225, Mur ligase family,catalytic domain, score 7.5e-34 471473000689 HMMPfam hit to PF08245, Mur ligase middle domain,score 5.8e-15 471473000690 HMMPfam hit to PF02875, Mur ligase family,glutamate ligase d, score 3.6e-26 471473000691 HMMPfam hit to PF01820, D-ala D-ala ligase N-terminus, score 1.3e-61 471473000692 PS00017 ATP/GTP-binding site motif A (P-loop) 471473000693 PS00843 D-alanine--D-alanine ligase signature 1 471473000694 HMMPfam hit to PF07478, D-ala D-ala ligase C-terminus, score 1.3e-113 471473000695 HMMPfam hit to PF02222, ATP-grasp domain, score 0.0014 471473000696 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 471473000697 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cd02409 471473000698 G-X-X-G motif; other site 471473000699 PS00079 Multicopper oxidases signature 1 471473000700 1 probable transmembrane helix predicted for CTL0133 by TMHMM2.0 at aa 26-48 471473000701 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471473000702 anti sigma factor interaction site; other site 471473000703 regulatory phosphorylation site [posttranslational modification]; other site 471473000704 HMMPfam hit to PF01740, STAS domain, score 7.2e-28 471473000705 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 471473000706 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 471473000707 PS00017 ATP/GTP-binding site motif A (P-loop) 471473000708 HMMPfam hit to PF01715, IPP transferase, score 2.7e-72 471473000709 hypothetical protein; Provisional; Region: PRK05927 471473000710 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 471473000711 FeS/SAM binding site; other site 471473000712 HMMPfam hit to PF04055, Radical SAM superfamily,score 7.7e-20 471473000713 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 471473000714 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 471473000715 HMMPfam hit to PF02410, Domain of unknown function DUF143, score 6.6e-55 471473000716 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 471473000717 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 471473000718 dimer interface [polypeptide binding]; other site 471473000719 active site 471473000720 HMMPfam hit to PF00109, Beta-ketoacyl synthase,N-terminal do, score 8.7e-87 471473000721 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 471473000722 PS00205 Transferrins signature 1 471473000723 PS00606 Beta-ketoacyl synthases active site 471473000724 HMMPfam hit to PF02801, Beta-ketoacyl synthase,C-terminal do, score 2.7e-64 471473000725 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 471473000726 active site 471473000727 Ap4A binding cleft/pocket [chemical binding]; other site 471473000728 P4 phosphate binding site; other site 471473000729 nudix motif; other site 471473000730 putative P2/P3 phosphate binding site [ion binding]; other site 471473000731 HMMPfam hit to PF00293, NUDIX domain, score 6.9e-25 471473000732 PS00893 mutT domain signature 471473000733 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 471473000734 dimer interface [polypeptide binding]; other site 471473000735 substrate binding site [chemical binding]; other site 471473000736 metal binding sites [ion binding]; metal-binding site 471473000737 HMMPfam hit to PF00719, Inorganic pyrophosphatase,score 5.8e-16 471473000738 PS00387 Inorganic pyrophosphatase signature 471473000739 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 471473000740 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 471473000741 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 471473000742 NAD binding site [chemical binding]; other site 471473000743 Phe binding site; other site 471473000744 HMMPfam hit to PF02812, Glu/Leu/Phe/Val dehydrogenase, dimeri, score 5.1e-18 471473000745 PS01109 Ribosomal protein L10 signature 471473000746 HMMPfam hit to PF00208,Glutamate/Leucine/Phenylalanine/Valin, score 3e-23 471473000747 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 471473000748 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 471473000749 active site 471473000750 putative lithium-binding site [ion binding]; other site 471473000751 substrate binding site [chemical binding]; other site 471473000752 HMMPfam hit to PF00459, Inositol monophosphatase family, score 2.1e-66 471473000753 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 471473000754 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 471473000755 putative acyl-acceptor binding pocket; other site 471473000756 HMMPfam hit to PF01553, Acyltransferase, score 0.00014 471473000757 long chain fatty acid--[acyl-carrier-protein] ligase; Validated; Region: PRK06334 471473000758 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471473000759 acyl-activating enzyme (AAE) consensus motif; other site 471473000760 AMP binding site [chemical binding]; other site 471473000761 active site 471473000762 CoA binding site [chemical binding]; other site 471473000763 HMMPfam hit to PF00501, AMP-binding enzyme, score 1.3e-87 471473000764 1 probable transmembrane helix predicted for CTL0145 by TMHMM2.0 at aa 69-91 471473000765 8-amino-7-oxononanoate synthase; Provisional; Region: PRK05937 471473000766 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 471473000767 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471473000768 catalytic residue [active] 471473000769 HMMPfam hit to PF00155, Aminotransferase class I and II, score 1.3e-15 471473000770 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site 471473000771 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 471473000772 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471473000773 ATP binding site [chemical binding]; other site 471473000774 putative Mg++ binding site [ion binding]; other site 471473000775 helicase superfamily c-terminal domain; Region: HELICc; smart00490 471473000776 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 0.0083 471473000777 HMMPfam hit to PF00270, DEAD/DEAH box helicase,score 5.1e-08 471473000778 HMMPfam hit to PF04851, Type III restriction enzyme,res subunit, score 1e-07 471473000779 PS00017 ATP/GTP-binding site motif A (P-loop) 471473000780 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 471473000781 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471473000782 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 471473000783 1 probable transmembrane helix predicted for CTL0149 by TMHMM2.0 at aa 4-23 471473000784 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 471473000785 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 471473000786 dimer interface [polypeptide binding]; other site 471473000787 putative anticodon binding site; other site 471473000788 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 471473000789 motif 1; other site 471473000790 dimer interface [polypeptide binding]; other site 471473000791 active site 471473000792 motif 2; other site 471473000793 motif 3; other site 471473000794 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 1.3e-12 471473000795 HMMPfam hit to PF00152, tRNA synthetases class II (D, K and N), score 4.5e-128 471473000796 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1 471473000797 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2 471473000798 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 471473000799 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 471473000800 active site 471473000801 HIGH motif; other site 471473000802 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 471473000803 KMSKS motif; other site 471473000804 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 471473000805 tRNA binding surface [nucleotide binding]; other site 471473000806 anticodon binding site; other site 471473000807 HMMPfam hit to PF01406, tRNA synthetases class I (C) catalytic d, score 1.7e-135 471473000808 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 471473000809 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471473000810 ribonuclease P; Reviewed; Region: rnpA; PRK00730 471473000811 HMMPfam hit to PF00825, Ribonuclease P, score 3.3e-14 471473000812 PS00648 Bacterial ribonuclease P protein component signature 471473000813 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 471473000814 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 471473000815 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 471473000816 HMMPfam hit to PF00253, Ribosomal protein S14p/S29e,score 7.6e-23 471473000817 PS00527 Ribosomal protein S14 signature 471473000818 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 471473000819 2 probable transmembrane helices predicted for CTL0156 by TMHMM2.0 at aa 5-24 and 31-53 471473000820 PS00636 Nt-dnaJ domain signature 471473000821 3 probable transmembrane helices predicted for CTL0157 by TMHMM2.0 at aa 12-29, 33-50 and 57-79 471473000822 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 471473000823 HMMPfam hit to PF03780, Protein of unknown function (DUF322), score 6.5e-43 471473000824 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 471473000825 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 471473000826 active site 471473000827 catalytic site [active] 471473000828 putative DNA binding site [nucleotide binding]; other site 471473000829 GIY-YIG motif/motif A; other site 471473000830 metal binding site [ion binding]; metal-binding site 471473000831 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 471473000832 HMMPfam hit to PF08459, UvrC Helix-hairpin-helix N-terminal, score 7.1e-73 471473000833 HMMPfam hit to PF01541, GIY-YIG catalytic domain,score 1.2e-22 471473000834 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 471473000835 MutS domain I; Region: MutS_I; pfam01624 471473000836 MutS domain II; Region: MutS_II; pfam05188 471473000837 MutS domain III; Region: MutS_III; pfam05192 471473000838 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 471473000839 Walker A/P-loop; other site 471473000840 ATP binding site [chemical binding]; other site 471473000841 Q-loop/lid; other site 471473000842 ABC transporter signature motif; other site 471473000843 Walker B; other site 471473000844 D-loop; other site 471473000845 H-loop/switch region; other site 471473000846 HMMPfam hit to PF00488, MutS domain V, score 5.9e-161 471473000847 PS00486 DNA mismatch repair proteins mutS family signature 471473000848 PS00017 ATP/GTP-binding site motif A (P-loop) 471473000849 HMMPfam hit to PF05192, MutS domain III, score 4.7e-74 471473000850 HMMPfam hit to PF05190, MutS family domain IV,score 9.7e-36 471473000851 HMMPfam hit to PF05188, MutS domain II, score 1.7e-38 471473000852 HMMPfam hit to PF01624, MutS domain I, score 1.9e-56 471473000853 DNA primase; Validated; Region: dnaG; PRK05667 471473000854 CHC2 zinc finger; Region: zf-CHC2; pfam01807 471473000855 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 471473000856 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 471473000857 active site 471473000858 metal binding site [ion binding]; metal-binding site 471473000859 interdomain interaction site; other site 471473000860 HMMPfam hit to PF01807, CHC2 zinc finger, score 3.8e-62 471473000861 HMMPfam hit to PF08275, DNA primase catalytic core,N-terminal domai, score 5.8e-51 471473000862 HMMPfam hit to PF01751, Toprim domain, score 7.4e-17 471473000863 1 probable transmembrane helix predicted for CTL0163 by TMHMM2.0 at aa 7-26 471473000864 glycyl-tRNA synthetase; Provisional; Region: PRK14908 471473000865 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 471473000866 dimer interface [polypeptide binding]; other site 471473000867 motif 1; other site 471473000868 active site 471473000869 motif 2; other site 471473000870 motif 3; other site 471473000871 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 471473000872 HMMPfam hit to PF05746, DALR anticodon binding domain, score 0.0021 471473000873 HMMPfam hit to PF02092, Glycyl-tRNA synthetase beta subunit, score 0 471473000874 HMMPfam hit to PF02091, Glycyl-tRNA synthetase alpha subunit, score 2.3e-235 471473000875 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2 471473000876 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 471473000877 5 probable transmembrane helices predicted for CTL0166 by TMHMM2.0 at aa 5-24, 29-51, 82-104, 134-156 and 163-185 471473000878 HMMPfam hit to PF01066, CDP-alcohol phosphatidyltransferase, score 1.4e-32 471473000879 PS00379 CDP-alcohol phosphatidyltransferases signature 471473000880 glycogen synthase; Provisional; Region: glgA; PRK00654 471473000881 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 471473000882 ADP-binding pocket [chemical binding]; other site 471473000883 homodimer interface [polypeptide binding]; other site 471473000884 HMMPfam hit to PF00534, Glycosyl transferases group,score 0.00047 471473000885 HMMPfam hit to PF08323, Starch synthase catalytic domain, score 1.5e-82 471473000886 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 471473000887 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 471473000888 5S rRNA interface [nucleotide binding]; other site 471473000889 CTC domain interface [polypeptide binding]; other site 471473000890 L16 interface [polypeptide binding]; other site 471473000891 HMMPfam hit to PF01386, Ribosomal L25p family,score 6.7e-09 471473000892 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 471473000893 putative active site [active] 471473000894 catalytic residue [active] 471473000895 HMMPfam hit to PF01195, Peptidyl-tRNA hydrolase,score 5.9e-48 471473000896 PS01195 Peptidyl-tRNA hydrolase signature 1 471473000897 PS01196 Peptidyl-tRNA hydrolase signature 2 471473000898 Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Region: RpsF; COG0360 471473000899 HMMPfam hit to PF01250, Ribosomal protein S6, score 4.7e-17 471473000900 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 471473000901 HMMPfam hit to PF01084, Ribosomal protein S18,score 2.1e-32 471473000902 PS00057 Ribosomal protein S18 signature 471473000903 Ribosomal protein L9 [Translation, ribosomal structure and biogenesis]; Region: RplI; COG0359 471473000904 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 471473000905 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 471473000906 HMMPfam hit to PF01281, Ribosomal protein L9,N-terminal domai, score 4.3e-15 471473000907 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK00650 471473000908 HMMPfam hit to PF00288, GHMP kinases N terminal domain, score 2.6e-14 471473000909 HMMPfam hit to PF08544, GHMP kinases C terminal,score 3.3e-05 471473000910 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 471473000911 HMMPfam hit to PF07399, Protein of unknown function (DUF1504), score 0 471473000912 11 probable transmembrane helices predicted for CTL0174 by TMHMM2.0 at aa 10-32, 61-83, 98-116,136-153,180-202, 223-242, 267-298, 311-330, 345-367,379-401 and 416-438 471473000913 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 471473000914 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 471473000915 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471473000916 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471473000917 HMMPfam hit to PF05193, Peptidase M16 inactive domain, score 1.2e-18 471473000918 HMMPfam hit to PF05193, Peptidase M16 inactive domain, score 1.6e-25 471473000919 HMMPfam hit to PF00675, Insulinase (Peptidase family M16), score 5.9e-26 471473000920 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 471473000921 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT; Region: LPLAT_GPAT; cd07985 471473000922 putative G3P-binding pocket; other site 471473000923 HMMPfam hit to PF01553, Acyltransferase, score 1.2e-38 471473000924 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 471473000925 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 471473000926 homodimer interface [polypeptide binding]; other site 471473000927 oligonucleotide binding site [chemical binding]; other site 471473000928 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 471473000929 HMMPfam hit to PF01783, Ribosomal L32p protein family, score 2.4e-23 471473000930 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature 471473000931 putative glycerol-3-phosphate acyltransferase PlsX; Provisional; Region: PRK13846 471473000932 HMMPfam hit to PF02504, Fatty acid synthesis protein, score 8.7e-176 471473000933 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 471473000934 Autotransporter beta-domain; Region: Autotransporter; pfam03797 471473000935 PS00430 TonB-dependent receptor proteins signature 1 471473000936 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 471473000937 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 8.5 471473000938 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 12 471473000939 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 1.9 471473000940 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 5.7 471473000941 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.08 471473000942 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 6.2 471473000943 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 33 471473000944 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 11 471473000945 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 4.2 471473000946 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 2 471473000947 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 5.7 471473000948 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.79 471473000949 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 9.8 471473000950 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.2 471473000951 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.0034 471473000952 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 2.8 471473000953 HMMPfam hit to PF07548, Chlamydia polymorphic membrane protei, score 1.2e-55 471473000954 HMMPfam hit to PF03797, Autotransporter beta-domain,score 1.2e-39 471473000955 Protein of unknown function (DUF972); Region: DUF972; pfam06156 471473000956 HMMPfam hit to PF04156, IncA protein, score 5.2e-43 471473000957 2 probable transmembrane helices predicted for CTL0184 by TMHMM2.0 at aa 40-62 and 72-94 471473000958 YtxH-like protein; Region: YtxH; cl02079 471473000959 1 probable transmembrane helix predicted for CTL0185 by TMHMM2.0 at aa 47-69 471473000960 1 probable transmembrane helix predicted for CTL0186 by TMHMM2.0 at aa 10-32 471473000961 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 471473000962 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 471473000963 active site 471473000964 substrate binding site [chemical binding]; other site 471473000965 metal binding site [ion binding]; metal-binding site 471473000966 HMMPfam hit to PF02878,Phosphoglucomutase/phosphomannomutase, al, score 2.9e-63 471473000967 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature 471473000968 HMMPfam hit to PF02879,Phosphoglucomutase/phosphomannomutase, al, score 8.1e-35 471473000969 HMMPfam hit to PF02880,Phosphoglucomutase/phosphomannomutase, al, score 1.3e-24 471473000970 HMMPfam hit to PF00408,Phosphoglucomutase/phosphomannomutase, C-, score 8.3e-05 471473000971 glucosamine--fructose-6-phosphate aminotransferase (isomerizing); Region: glmS; TIGR01135 471473000972 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 471473000973 glutaminase active site [active] 471473000974 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 471473000975 dimer interface [polypeptide binding]; other site 471473000976 active site 471473000977 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 471473000978 dimer interface [polypeptide binding]; other site 471473000979 active site 471473000980 HMMPfam hit to PF00310, Glutamine amidotransferases class-II, score 2.1e-33 471473000981 PS00211 ABC transporters family signature 471473000982 PS00017 ATP/GTP-binding site motif A (P-loop) 471473000983 HMMPfam hit to PF01380, SIS domain, score 2.7e-30 471473000984 HMMPfam hit to PF01380, SIS domain, score 1.1e-14 471473000985 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 471473000986 aromatic amino acid transport protein; Region: araaP; TIGR00837 471473000987 HMMPfam hit to PF03222, Tryptophan/tyrosine permease family, score 5.6e-219 471473000988 11 probable transmembrane helices predicted for CTL0189 by TMHMM2.0 at aa 7-29, 39-61, 82-101,121-138,151-170, 185-207, 219-241, 268-290, 311-330,340-357 and 370-392 471473000989 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 471473000990 aromatic amino acid transport protein; Region: araaP; TIGR00837 471473000991 HMMPfam hit to PF03222, Tryptophan/tyrosine permease family, score 4.1e-210 471473000992 11 probable transmembrane helices predicted for CTL0190 by TMHMM2.0 at aa 7-29, 39-61, 82-104,124-146,153-175, 190-209, 221-243, 272-294, 311-328,338-357 and 378-396 471473000993 motif repeated in this and the adjacent CDS gene product 471473000994 motif repeated in this and the adjacent CDS gene product 471473000995 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 471473000996 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 471473000997 HMMPfam hit to PF01027, Uncharacterised protein family UPF0005, score 2.4e-06 471473000998 7 probable transmembrane helices predicted for CTL0191 by TMHMM2.0 at aa 21-43, 48-67, 74-96,106-128,141-163, 167-186 and 206-228 471473000999 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 471473001000 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 471473001001 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 471473001002 HMMPfam hit to PF00448, SRP54-type protein, GTPase domain, score 1.2e-109 471473001003 PS00017 ATP/GTP-binding site motif A (P-loop) 471473001004 succinyl-CoA synthetase, beta subunit; Region: sucCoAbeta; TIGR01016 471473001005 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 471473001006 CoA-ligase; Region: Ligase_CoA; pfam00549 471473001007 HMMPfam hit to PF08442, ATP-grasp domain, score 1.9e-82 471473001008 HMMPfam hit to PF01071, Phosphoribosylglycinamide synthetase, ATP, score 0.0025 471473001009 HMMPfam hit to PF00549, CoA-ligase, score 5.2e-41 471473001010 2 probable transmembrane helices predicted for CTL0193 by TMHMM2.0 at aa 248-270 and 313-335 471473001011 PS01217 ATP-citrate lyase / succinyl-CoA ligases family signature 3 471473001012 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 471473001013 CoA binding domain; Region: CoA_binding; smart00881 471473001014 CoA-ligase; Region: Ligase_CoA; pfam00549 471473001015 HMMPfam hit to PF02629, CoA binding domain, score 9.2e-44 471473001016 HMMPfam hit to PF00549, CoA-ligase, score 2.4e-57 471473001017 PS01216 ATP-citrate lyase / succinyl-CoA ligases family signature 1 471473001018 PS00399 ATP-citrate lyase / succinyl-CoA ligases family active site 471473001019 PS00017 ATP/GTP-binding site motif A (P-loop) 471473001020 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 471473001021 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 471473001022 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 471473001023 protein binding site [polypeptide binding]; other site 471473001024 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 471473001025 protein binding site [polypeptide binding]; other site 471473001026 HMMPfam hit to PF00089, Trypsin, score 2e-18 471473001027 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 1.5e-12 471473001028 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 0.0014 471473001029 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 471473001030 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 471473001031 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471473001032 Peptidase M16C associated; Region: M16C_assoc; pfam08367 471473001033 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471473001034 HMMPfam hit to PF00675, Insulinase (Peptidase family M16), score 0.019 471473001035 HMMPfam hit to PF05193, Peptidase M16 inactive domain, score 1e-27 471473001036 HMMPfam hit to PF08367, Peptidase M16C associated,score 4e-118 471473001037 HMMPfam hit to PF05193, Peptidase M16 inactive domain, score 2.1e-24 471473001038 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 471473001039 RmuC family; Region: RmuC; pfam02646 471473001040 HMMPfam hit to PF02646, RmuC family, score 6.2e-140 471473001041 1 probable transmembrane helix predicted for CTL0197 by TMHMM2.0 at aa 13-35 471473001042 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 471473001043 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 471473001044 7 probable transmembrane helices predicted for CTL0198 by TMHMM2.0 at aa 15-37, 79-101, 111-133,145-167,182-204, 211-230 and 235-257 471473001045 HMMPfam hit to PF01066, CDP-alcohol phosphatidyltransferase, score 4.7e-22 471473001046 PS00379 CDP-alcohol phosphatidyltransferases signature 471473001047 ribonucleotide-diphosphate reductase subunit alpha; Provisional; Region: PRK12365 471473001048 ATP cone domain; Region: ATP-cone; pfam03477 471473001049 ATP cone domain; Region: ATP-cone; pfam03477 471473001050 Class I ribonucleotide reductase; Region: RNR_I; cd01679 471473001051 active site 471473001052 dimer interface [polypeptide binding]; other site 471473001053 catalytic residues [active] 471473001054 effector binding site; other site 471473001055 R2 peptide binding site; other site 471473001056 HMMPfam hit to PF03477, ATP cone domain, score 7.1e-32 471473001057 HMMPfam hit to PF03477, ATP cone domain, score 1.6e-33 471473001058 HMMPfam hit to PF03477, ATP cone domain, score 2e-08 471473001059 HMMPfam hit to PF00317, Ribonucleotide reductase,all-alpha d, score 4.4e-30 471473001060 PS00185 Isopenicillin N synthetase signature 1 471473001061 HMMPfam hit to PF02867, Ribonucleotide reductase,barrel doma, score 1.1e-183 471473001062 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 471473001063 dimer interface [polypeptide binding]; other site 471473001064 putative radical transfer pathway; other site 471473001065 diiron center [ion binding]; other site 471473001066 tyrosyl radical; other site 471473001067 HMMPfam hit to PF00268, Ribonucleotide reductase,small chain, score 7e-35 471473001068 1 probable transmembrane helix predicted for CTL0200 by TMHMM2.0 at aa 185-207 471473001069 Putative methyltransferase; Region: Methyltransf_4; pfam02390 471473001070 HMMPfam hit to PF02390, Putative methyltransferase,score 2.2e-81 471473001071 Methyltransferase domain; Region: Methyltransf_18; pfam12847 471473001072 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 471473001073 HMMPfam hit to PF06962, Putative rRNA methylase,score 3.3e-75 471473001074 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 471473001075 FAD binding domain; Region: FAD_binding_4; pfam01565 471473001076 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 471473001077 HMMPfam hit to PF02873,UDP-N-acetylenolpyruvoylglucosamine red, score 3.4e-58 471473001078 HMMPfam hit to PF01565, FAD binding domain, score 5.4e-13 471473001079 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 471473001080 putative RNA binding site [nucleotide binding]; other site 471473001081 HMMPfam hit to PF01029, NusB family, score 3e-39 471473001082 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 471473001083 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 471473001084 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 471473001085 HMMPfam hit to PF05198, Translation initiation factor IF-3, N-termin, score 5.2e-48 471473001086 PS00938 Initiation factor 3 signature 471473001087 HMMPfam hit to PF00707, Translation initiation factor IF-3, C-termin, score 2.1e-51 471473001088 Ribosomal protein L35 [Translation, ribosomal structure and biogenesis]; Region: RpmI; COG0291 471473001089 HMMPfam hit to PF01632, Ribosomal protein L35,score 2.6e-11 471473001090 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 471473001091 23S rRNA binding site [nucleotide binding]; other site 471473001092 L21 binding site [polypeptide binding]; other site 471473001093 L13 binding site [polypeptide binding]; other site 471473001094 HMMPfam hit to PF00453, Ribosomal protein L20,score 2.4e-32 471473001095 PS00937 Ribosomal protein L20 signature 471473001096 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 471473001097 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 471473001098 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 471473001099 motif 1; other site 471473001100 dimer interface [polypeptide binding]; other site 471473001101 active site 471473001102 motif 2; other site 471473001103 motif 3; other site 471473001104 HMMPfam hit to PF02912, Aminoacyl tRNA synthetase class II, N, score 8e-26 471473001105 HMMPfam hit to PF01409, tRNA synthetases class II core domain, score 1.4e-145 471473001106 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature 471473001107 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2 471473001108 Predicted permeases [General function prediction only]; Region: COG0795 471473001109 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 471473001110 HMMPfam hit to PF03739, Predicted permease YjgP/YjgQ family, score 2.2e-70 471473001111 4 probable transmembrane helices predicted for CTL0210 by TMHMM2.0 at aa 7-29, 279-301, 313-335 and 340-362 471473001112 Predicted permeases [General function prediction only]; Region: COG0795 471473001113 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 471473001114 HMMPfam hit to PF03739, Predicted permease YjgP/YjgQ family, score 7e-79 471473001115 6 probable transmembrane helices predicted for CTL0211 by TMHMM2.0 at aa 17-39, 54-76, 97-116,274-293,300-317 and 322-344 471473001116 PS00017 ATP/GTP-binding site motif A (P-loop) 471473001117 PS00017 ATP/GTP-binding site motif A (P-loop) 471473001118 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 471473001119 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 471473001120 Ligand Binding Site [chemical binding]; other site 471473001121 HMMPfam hit to PF01171, PP-loop family, score 2e-69 471473001122 HMMPfam hit to PF06508, ExsB, score 0.0036 471473001123 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 471473001124 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471473001125 Walker A motif; other site 471473001126 ATP binding site [chemical binding]; other site 471473001127 Walker B motif; other site 471473001128 arginine finger; other site 471473001129 Peptidase family M41; Region: Peptidase_M41; pfam01434 471473001130 2 probable transmembrane helices predicted for CTL0213 by TMHMM2.0 at aa 15-37 and 372-394 471473001131 HMMPfam hit to PF06480, FtsH Extracellular, score 1.8e-36 471473001132 HMMPfam hit to PF00004, ATPase family associated with various c, score 1.3e-91 471473001133 HMMPfam hit to PF07728, ATPase family associated with various c, score 0.00022 471473001134 PS00017 ATP/GTP-binding site motif A (P-loop) 471473001135 PS00674 AAA-protein family signature 471473001136 HMMPfam hit to PF01434, Peptidase family M41, score 4.3e-121 471473001137 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 471473001138 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 471473001139 RNase E interface [polypeptide binding]; other site 471473001140 trimer interface [polypeptide binding]; other site 471473001141 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 471473001142 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 471473001143 RNase E interface [polypeptide binding]; other site 471473001144 trimer interface [polypeptide binding]; other site 471473001145 active site 471473001146 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 471473001147 putative nucleic acid binding region [nucleotide binding]; other site 471473001148 G-X-X-G motif; other site 471473001149 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 471473001150 RNA binding site [nucleotide binding]; other site 471473001151 domain interface; other site 471473001152 HMMPfam hit to PF00575, S1 RNA binding domain,score 3.3e-16 471473001153 HMMPfam hit to PF00013, KH domain, score 5.7e-16 471473001154 HMMPfam hit to PF03725, 3' exoribonuclease family,domain, score 5.7e-23 471473001155 HMMPfam hit to PF01138, 3' exoribonuclease family,domain, score 1.3e-46 471473001156 HMMPfam hit to PF03726, Polyribonucleotide nucleotidyltransferase,, score 0.00014 471473001157 HMMPfam hit to PF03725, 3' exoribonuclease family,domain, score 1.1e-14 471473001158 HMMPfam hit to PF01138, 3' exoribonuclease family,domain, score 8.9e-28 471473001159 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 471473001160 16S/18S rRNA binding site [nucleotide binding]; other site 471473001161 S13e-L30e interaction site [polypeptide binding]; other site 471473001162 25S rRNA binding site [nucleotide binding]; other site 471473001163 HMMPfam hit to PF00312, Ribosomal protein S15,score 7.6e-27 471473001164 PS00362 Ribosomal protein S15 signature 471473001165 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 471473001166 nucleoside/Zn binding site; other site 471473001167 dimer interface [polypeptide binding]; other site 471473001168 catalytic motif [active] 471473001169 HMMPfam hit to PF00383, Cytidine and deoxycytidylate deaminas, score 1.8e-45 471473001170 4 probable transmembrane helices predicted for CTL0218 by TMHMM2.0 at aa 22-44, 120-142, 147-165 and 185-207 471473001171 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 471473001172 Protein of unknown function (DUF720); Region: DUF720; pfam05302 471473001173 HMMPfam hit to PF05302, Protein of unknown function (DUF720), score 1.7e-90 471473001174 Protein of unknown function (DUF720); Region: DUF720; pfam05302 471473001175 HMMPfam hit to PF05302, Protein of unknown function (DUF720), score 3.3e-82 471473001176 Protein of unknown function (DUF720); Region: DUF720; pfam05302 471473001177 HMMPfam hit to PF05302, Protein of unknown function (DUF720), score 5.2e-76 471473001178 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 471473001179 4 probable transmembrane helices predicted for CTL0223 by TMHMM2.0 at aa 15-37, 44-66, 71-88 and 95-117 471473001180 methionine aminopeptidase; Provisional; Region: PRK12318 471473001181 SEC-C motif; Region: SEC-C; pfam02810 471473001182 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 471473001183 active site 471473001184 HMMPfam hit to PF00557, metallopeptidase family M24,score 4.8e-54 471473001185 PS00215 Mitochondrial energy transfer proteins signature 471473001186 HMMPfam hit to PF02810, SEC-C motif, score 5e-10 471473001187 MarC family integral membrane protein; Region: MarC; pfam01914 471473001188 HMMPfam hit to PF01914, MarC family integral membrane protein, score 2.3e-82 471473001189 6 probable transmembrane helices predicted for CTL0225 by TMHMM2.0 at aa 10-29, 41-63, 67-86,107-129,139-161 and 174-196 471473001190 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2 471473001191 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 471473001192 HMMPfam hit to PF01914, MarC family integral membrane protein, score 0.00012 471473001193 5 probable transmembrane helices predicted for CTL0226 by TMHMM2.0 at aa 47-66, 73-92, 112-134, 139-161 and 171-193 471473001194 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 471473001195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471473001196 dimer interface [polypeptide binding]; other site 471473001197 conserved gate region; other site 471473001198 putative PBP binding loops; other site 471473001199 ABC-ATPase subunit interface; other site 471473001200 NMT1/THI5 like; Region: NMT1; pfam09084 471473001201 6 probable transmembrane helices predicted for CTL0227 by TMHMM2.0 at aa 4-21, 59-81, 91-113,172-194,214-236 and 257-274 471473001202 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1.6e-31 471473001203 The sequence has been checked and is believed to be correct 471473001204 HMMPfam hit to PF00206, Lyase, score 3.7e-132 471473001205 high affinity sulphate transporter 1; Region: sulP; TIGR00815 471473001206 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 471473001207 Sulfate transporter family; Region: Sulfate_transp; pfam00916 471473001208 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 471473001209 HMMPfam hit to PF01740, STAS domain, score 4.7e-19 471473001210 HMMPfam hit to PF00916, Sulfate transporter family,score 3.5e-57 471473001211 HMMPfam hit to PF00860, Permease family, score 0.0087 471473001212 10 probable transmembrane helices predicted for CTL0231 by TMHMM2.0 at aa 33-55, 60-82, 105-127,134-151,177-199, 206-223, 257-279, 325-347, 357-379 and 386-408 471473001213 Na+/H+ antiporter, NhaD family; Region: NhaD; TIGR00775 471473001214 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 471473001215 11 probable transmembrane helices predicted for CTL0232 by TMHMM2.0 at aa 7-25, 30-49, 61-78,98-127,139-158, 173-195, 240-259, 279-301, 322-344, 359-381 and 394-413 471473001216 HMMPfam hit to PF03600, Citrate transporter, score 0.00094 471473001217 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 471473001218 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 471473001219 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 471473001220 active site triad [active] 471473001221 HMMPfam hit to PF03572, Peptidase family S41, score 6.1e-44 471473001222 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 471473001223 LytB protein; Region: LYTB; pfam02401 471473001224 HMMPfam hit to PF02401, LytB protein, score 2.9e-183 471473001225 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 471473001226 4 probable transmembrane helices predicted for CTL0236 by TMHMM2.0 at aa 316-338, 342-364, 385-407 and 422-441 471473001227 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 471473001228 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471473001229 binding surface 471473001230 TPR motif; other site 471473001231 HMMPfam hit to PF07720, Tetratricopeptide repeat,score 1.5e-08 471473001232 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 471473001233 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471473001234 active site 471473001235 DNA binding site [nucleotide binding] 471473001236 Int/Topo IB signature motif; other site 471473001237 HMMPfam hit to PF00589, Phage integrase family,score 1.9e-39 471473001238 HMMPfam hit to PF02899, Phage integrase, N-terminal SAM-like, score 1.1e-24 471473001239 glycogen branching enzyme; Provisional; Region: PRK05402 471473001240 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 471473001241 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 471473001242 active site 471473001243 catalytic site [active] 471473001244 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 471473001245 HMMPfam hit to PF02922, Isoamylase N-terminal domain, score 1.3e-33 471473001246 HMMPfam hit to PF00128, Alpha amylase, catalytic domain, score 8.5e-09 471473001247 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784 471473001248 1 probable transmembrane helix predicted for CTL0246 by TMHMM2.0 at aa 33-55 471473001249 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784 471473001250 1 probable transmembrane helix predicted for CTL0247 by TMHMM2.0 at aa 41-60 471473001251 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 471473001252 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 471473001253 Autotransporter beta-domain; Region: Autotransporter; pfam03797 471473001254 HMMPfam hit to PF03797, Autotransporter beta-domain,score 1.7e-38 471473001255 HMMPfam hit to PF07548, Chlamydia polymorphic membrane protei, score 3.7e-51 471473001256 PS00237 G-protein coupled receptors signature 471473001257 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.07 471473001258 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 1 471473001259 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.79 471473001260 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 3.7 471473001261 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 2.2 471473001262 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 12 471473001263 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 1 471473001264 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 9.6 471473001265 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 471473001266 Autotransporter beta-domain; Region: Autotransporter; pfam03797 471473001267 HMMPfam hit to PF03797, Autotransporter beta-domain,score 5.2e-41 471473001268 HMMPfam hit to PF07548, Chlamydia polymorphic membrane protei, score 3.1e-53 471473001269 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 5.8 471473001270 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 5.5 471473001271 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.19 471473001272 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.15 471473001273 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 4.8 471473001274 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 7.7 471473001275 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.27 471473001276 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 2.2 471473001277 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 471473001278 Autotransporter beta-domain; Region: Autotransporter; pfam03797 471473001279 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 471473001280 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.87 471473001281 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 1.6 471473001282 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 9.6 471473001283 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 13 471473001284 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.16 471473001285 PS00017 ATP/GTP-binding site motif A (P-loop) 471473001286 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.18 471473001287 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.011 471473001288 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 2.8 471473001289 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 12 471473001290 HMMPfam hit to PF07548, Chlamydia polymorphic membrane protei, score 3.9e-53 471473001291 HMMPfam hit to PF03797, Autotransporter beta-domain,score 3.3e-40 471473001292 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 471473001293 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 471473001294 Autotransporter beta-domain; Region: Autotransporter; pfam03797 471473001295 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 2.1 471473001296 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 8.9 471473001297 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 1.1 471473001298 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.0032 471473001299 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.3 471473001300 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 50 471473001301 HMMPfam hit to PF07548, Chlamydia polymorphic membrane protei, score 9.4e-49 471473001302 HMMPfam hit to PF03797, Autotransporter beta-domain,score 4.4e-37 471473001303 PS00435 Peroxidases proximal heme-ligand signature 471473001304 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 471473001305 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 471473001306 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 471473001307 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 471473001308 Autotransporter beta-domain; Region: Autotransporter; pfam03797 471473001309 HMMPfam hit to PF03797, Autotransporter beta-domain,score 5.5e-40 471473001310 PS00017 ATP/GTP-binding site motif A (P-loop) 471473001311 HMMPfam hit to PF07548, Chlamydia polymorphic membrane protei, score 1.7e-54 471473001312 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.54 471473001313 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.043 471473001314 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.086 471473001315 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.13 471473001316 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.075 471473001317 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.36 471473001318 Uncharacterized conserved protein [Function unknown]; Region: COG2155 471473001319 HMMPfam hit to PF04070, Domain of unknown function (DUF378), score 2.1e-43 471473001320 2 probable transmembrane helices predicted for CTL0256 by TMHMM2.0 at aa 5-27 and 42-64 471473001321 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 471473001322 HMMPfam hit to PF02686, Glu-tRNAGln amidotransferase C subunit, score 7e-32 471473001323 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 471473001324 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 471473001325 HMMPfam hit to PF01425, Amidase, score 4.6e-213 471473001326 PS00571 Amidases signature 471473001327 Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) [Translation, ribosomal structure and biogenesis]; Region: GatB; COG0064 471473001328 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 471473001329 GatB domain; Region: GatB_Yqey; pfam02637 471473001330 HMMPfam hit to PF02934, PET112 family, N terminal region, score 3.8e-139 471473001331 PS01234 PET112 family signature 471473001332 HMMPfam hit to PF01162, PET112 family, C terminal region, score 1.2e-34 471473001333 HMMPfam hit to PF02637, GatB/Yqey domain, score 5.2e-54 471473001334 4 probable transmembrane helices predicted for CTL0260 by TMHMM2.0 at aa 32-54, 59-81, 96-118 and 123-145 471473001335 3 probable transmembrane helices predicted for CTL0261 by TMHMM2.0 at aa 47-69, 89-111 and 118-140 471473001336 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 471473001337 ribonuclease HIII; Region: rnhC; TIGR00716 471473001338 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 471473001339 RNA/DNA hybrid binding site [nucleotide binding]; other site 471473001340 active site 471473001341 HMMPfam hit to PF01351, Ribonuclease HII, score 2.5e-09 471473001342 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 471473001343 Helix-turn-helix domain; Region: HTH_25; pfam13413 471473001344 1 probable transmembrane helix predicted for CTL0264 by TMHMM2.0 at aa 117-139 471473001345 lipid A biosynthesis lauroyl acyltransferase; Provisional; Region: PRK05906 471473001346 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 471473001347 putative acyl-acceptor binding pocket; other site 471473001348 HMMPfam hit to PF03279, Bacterial lipid A biosynthesis acyltr, score 7.2e-155 471473001349 1 probable transmembrane helix predicted for CTL0265 by TMHMM2.0 at aa 12-34 471473001350 1 probable transmembrane helix predicted for CTL0266 by TMHMM2.0 at aa 13-35 471473001351 Uncharacterized conserved protein [Function unknown]; Region: COG1624 471473001352 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 471473001353 HMMPfam hit to PF02457, Domain of unknown function DUF147, score 1.8e-67 471473001354 3 probable transmembrane helices predicted for CTL0267 by TMHMM2.0 at aa 4-26, 28-50 and 65-87 471473001355 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 471473001356 HMMPfam hit to PF01654, Bacterial Cytochrome Ubiquinol Oxidase, score 8.8e-135 471473001357 9 probable transmembrane helices predicted for CTL0268 by TMHMM2.0 at aa 10-32, 52-74, 94-116,128-150,185-207, 220-239, 321-343, 356-378 and 406-428 471473001358 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 471473001359 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 471473001360 8 probable transmembrane helices predicted for CTL0269 by TMHMM2.0 at aa 5-27, 66-88, 123-145,165-187,200-222, 237-259, 272-294 and 321-343 471473001361 HMMPfam hit to PF02322, Cytochrome oxidase subunit II, score 3.5e-183 471473001362 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 471473001363 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 471473001364 putative active site [active] 471473001365 PhoH-like protein; Region: PhoH; pfam02562 471473001366 HMMPfam hit to PF02562, PhoH-like protein, score 8.8e-23 471473001367 PS00017 ATP/GTP-binding site motif A (P-loop) 471473001368 Bacterial SH3 domain homologues; Region: SH3b; smart00287 471473001369 Bacterial SH3 domain homologues; Region: SH3b; smart00287 471473001370 HMMPfam hit to PF08239, Bacterial SH3 domain, score 0.0031 471473001371 HMMPfam hit to PF08239, Bacterial SH3 domain, score 2.5e-08 471473001372 1 probable transmembrane helix predicted for CTL0273 by TMHMM2.0 at aa 25-47 471473001373 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 471473001374 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 471473001375 HIGH motif; other site 471473001376 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 471473001377 active site 471473001378 KMSKS motif; other site 471473001379 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 471473001380 tRNA binding surface [nucleotide binding]; other site 471473001381 anticodon binding site; other site 471473001382 HMMPfam hit to PF00133, tRNA synthetases class I (I,L, M and V), score 1.3e-279 471473001383 PS00178 Aminoacyl-transfer RNA synthetases class-I signature 471473001384 HMMPfam hit to PF08264, Anticodon-binding domain,score 4e-58 471473001385 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 471473001386 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 471473001387 Catalytic site [active] 471473001388 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 471473001389 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 471473001390 2 probable transmembrane helices predicted for CTL0275 by TMHMM2.0 at aa 85-104 and 598-620 471473001391 PS00761 Signal peptidases I signature 3 471473001392 HMMPfam hit to PF00717, Peptidase S24-like, score 7.1e-09 471473001393 1 probable transmembrane helix predicted for CTL0276 by TMHMM2.0 at aa 12-29 471473001394 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 471473001395 HMMPfam hit to PF01197, Ribosomal protein L31,score 1.2e-11 471473001396 PS01143 Ribosomal protein L31 signature 471473001397 peptide chain release factor 1; Validated; Region: prfA; PRK00591 471473001398 PCRF domain; Region: PCRF; pfam03462 471473001399 RF-1 domain; Region: RF-1; pfam00472 471473001400 HMMPfam hit to PF03462, PCRF domain, score 4.4e-56 471473001401 HMMPfam hit to PF00472, Peptidyl-tRNA hydrolase domain, score 1.4e-80 471473001402 PS00745 Prokaryotic-type class I peptide chain release factors signature 471473001403 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 471473001404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471473001405 S-adenosylmethionine binding site [chemical binding]; other site 471473001406 HMMPfam hit to PF05175, Methyltransferase small domain, score 5.4e-08 471473001407 PS00262 Insulin family signature 471473001408 PS00092 N-6 Adenine-specific DNA methylases signature 471473001409 signal recognition particle protein; Provisional; Region: PRK10867 471473001410 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 471473001411 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 471473001412 P loop; other site 471473001413 GTP binding site [chemical binding]; other site 471473001414 Signal peptide binding domain; Region: SRP_SPB; pfam02978 471473001415 HMMPfam hit to PF02881, SRP54-type protein, helical bundle domain, score 3.2e-31 471473001416 HMMPfam hit to PF00448, SRP54-type protein, GTPase domain, score 6.5e-111 471473001417 PS00017 ATP/GTP-binding site motif A (P-loop) 471473001418 HMMPfam hit to PF02978, Signal peptide binding domain, score 3.9e-49 471473001419 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14522 471473001420 HMMPfam hit to PF00886, Ribosomal protein S16,score 6.4e-17 471473001421 tRNA (guanine-N(1)-)-methyltransferase/unknown domain fusion protein; Reviewed; Region: trmD; PRK01037 471473001422 tRNA-(guanine-N1)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmD; COG0336 471473001423 HMMPfam hit to PF01746, tRNA (Guanine-1)-methyltransferase, score 9.3e-53 471473001424 ribosomal protein L19, bacterial type; Region: rplS_bact; TIGR01024 471473001425 HMMPfam hit to PF01245, Ribosomal protein L19,score 7.6e-45 471473001426 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 471473001427 RNA/DNA hybrid binding site [nucleotide binding]; other site 471473001428 active site 471473001429 HMMPfam hit to PF01351, Ribonuclease HII, score 2.4e-64 471473001430 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 471473001431 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 471473001432 catalytic site [active] 471473001433 G-X2-G-X-G-K; other site 471473001434 PS00017 ATP/GTP-binding site motif A (P-loop) 471473001435 PS00856 Guanylate kinase signature 471473001436 HMMPfam hit to PF00625, Guanylate kinase, score 7.4e-30 471473001437 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 471473001438 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 471473001439 active site 471473001440 HIGH motif; other site 471473001441 KMSKS motif; other site 471473001442 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 471473001443 tRNA binding surface [nucleotide binding]; other site 471473001444 anticodon binding site; other site 471473001445 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 471473001446 AAA domain; Region: AAA_30; pfam13604 471473001447 Family description; Region: UvrD_C_2; pfam13538 471473001448 PS00017 ATP/GTP-binding site motif A (P-loop) 471473001449 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 471473001450 10 probable transmembrane helices predicted for CTL0289 by TMHMM2.0 at aa 5-27, 31-48, 60-82,86-108,115-137, 147-169, 190-212, 227-246, 253-275 and 285-304 471473001451 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 471473001452 conserved cys residue [active] 471473001453 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 471473001454 2 probable transmembrane helices predicted for CTL0291 by TMHMM2.0 at aa 12-34 and 38-57 471473001455 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 471473001456 The sequence has been checked and is believed to be correct 471473001457 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471473001458 1 probable transmembrane helix predicted for CTL0293 by TMHMM2.0 at aa 21-38 471473001459 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 471473001460 trimer interface [polypeptide binding]; other site 471473001461 active site 471473001462 Holliday junction resolvasome, helicase subunit [DNA replication, recombination, and repair]; Region: RuvB; COG2255 471473001463 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471473001464 Walker A motif; other site 471473001465 ATP binding site [chemical binding]; other site 471473001466 Walker B motif; other site 471473001467 arginine finger; other site 471473001468 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 471473001469 HMMPfam hit to PF05496, Holliday junction DNA helicase ruvB N-termin, score 2.1e-08 471473001470 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 1.7e-37 471473001471 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 2.4e-05 471473001472 PS00017 ATP/GTP-binding site motif A (P-loop) 471473001473 HMMPfam hit to PF05491, Holliday junction DNA helicase ruvB C-termin, score 1.9e-49 471473001474 PS00070 Aldehyde dehydrogenases cysteine active site 471473001475 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 471473001476 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 471473001477 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 471473001478 active site 471473001479 catalytic site [active] 471473001480 HMMPfam hit to PF00128, Alpha amylase, catalytic domain, score 8.6e-16 471473001481 HMMPfam hit to PF02922, Isoamylase N-terminal domain, score 1.8e-18 471473001482 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 471473001483 HMMPfam hit to PF05932, Tir chaperone protein (CesT), score 1.2e-37 471473001484 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 471473001485 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 471473001486 dimer interface [polypeptide binding]; other site 471473001487 ssDNA binding site [nucleotide binding]; other site 471473001488 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471473001489 HMMPfam hit to PF00436, Single-strand binding protein family, score 6.1e-10 471473001490 multifunctional aminopeptidase A; Provisional; Region: PRK00913 471473001491 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 471473001492 interface (dimer of trimers) [polypeptide binding]; other site 471473001493 Substrate-binding/catalytic site; other site 471473001494 Zn-binding sites [ion binding]; other site 471473001495 HMMPfam hit to PF02789, Cytosol aminopeptidase family, N-term, score 2.3e-26 471473001496 HMMPfam hit to PF00883, Cytosol aminopeptidase family, cataly, score 1.8e-146 471473001497 Histone H1-like nucleoprotein HC2; Region: HC2; pfam07382 471473001498 HMMPfam hit to PF07382, Histone H1-like nucleoprotein HC2, score 4e-99 471473001499 hypothetical protein; Provisional; Region: PRK05907 471473001500 HMMPfam hit to PF06144, DNA polymerase III, delta subunit, score 0.00038 471473001501 Predicted methyltransferases [General function prediction only]; Region: COG0313 471473001502 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 471473001503 putative SAM binding site [chemical binding]; other site 471473001504 homodimer interface [polypeptide binding]; other site 471473001505 PS00070 Aldehyde dehydrogenases cysteine active site 471473001506 coproporphyrinogen III oxidase; Provisional; Region: PRK06294 471473001507 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471473001508 FeS/SAM binding site; other site 471473001509 HemN C-terminal domain; Region: HemN_C; pfam06969 471473001510 HMMPfam hit to PF06969, HemN C-terminal region,score 3e-24 471473001511 HMMPfam hit to PF04055, Radical SAM superfamily,score 2.6e-28 471473001512 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; Region: SucA; COG0567 471473001513 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 471473001514 TPP-binding site [chemical binding]; other site 471473001515 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 471473001516 HMMPfam hit to PF00676, Dehydrogenase E1 component,score 1.8e-43 471473001517 HMMPfam hit to PF02779, Transketolase, pyridine binding domain, score 2.6e-58 471473001518 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 471473001519 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471473001520 E3 interaction surface; other site 471473001521 lipoyl attachment site [posttranslational modification]; other site 471473001522 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 471473001523 HMMPfam hit to PF00364, Biotin-requiring enzyme,score 3.4e-13 471473001524 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site 471473001525 HMMPfam hit to PF00198, 2-oxoacid dehydrogenases acyltransferas, score 4e-135 471473001526 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 471473001527 uncharacterized protein, YfiH family; Region: TIGR00726 471473001528 HMMPfam hit to PF02578, Uncharacterised ACR, YfiH family COG1496, score 1.1e-115 471473001529 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 471473001530 1-hydroxy-2-methyl-2-(e)-butenyl 4-diphosphate synthase [Lipid metabolism]; Region: gcpE; COG0821 471473001531 HMMPfam hit to PF04551, GcpE protein, score 4.3e-59 471473001532 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 471473001533 ADP-ribose binding site [chemical binding]; other site 471473001534 2 probable transmembrane helices predicted for CTL0314 by TMHMM2.0 at aa 26-48 and 53-75 471473001535 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 471473001536 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471473001537 catalytic loop [active] 471473001538 iron binding site [ion binding]; other site 471473001539 HMMPfam hit to PF00111, 2Fe-2S iron-sulfur cluster binding domain, score 8.1e-13 471473001540 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature 471473001541 type III secretion system protein; Validated; Region: PRK05910 471473001542 FHIPEP family; Region: FHIPEP; pfam00771 471473001543 7 probable transmembrane helices predicted for CTL0316 by TMHMM2.0 at aa 33-52, 56-78, 90-112,127-149,218-237, 252-274 and 294-316 471473001544 HMMPfam hit to PF00771, FHIPEP family, score 2e-230 471473001545 RNA polymerase sigma factor sigma-28; Reviewed; Region: PRK05911 471473001546 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471473001547 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 471473001548 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471473001549 DNA binding residues [nucleotide binding] 471473001550 HMMPfam hit to PF04542, Sigma-70 region, score 2.5e-21 471473001551 HMMPfam hit to PF04539, Sigma-70 region, score 9.9e-07 471473001552 HMMPfam hit to PF08281, Sigma-70, region, score 6.9e-10 471473001553 HMMPfam hit to PF04545, Sigma-70, region, score 7.2e-21 471473001554 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 471473001555 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 471473001556 active site 471473001557 HIGH motif; other site 471473001558 dimer interface [polypeptide binding]; other site 471473001559 KMSKS motif; other site 471473001560 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471473001561 RNA binding surface [nucleotide binding]; other site 471473001562 HMMPfam hit to PF00579, tRNA synthetases class I (W and Y), score 1.3e-120 471473001563 HMMPfam hit to PF01479, S4 domain, score 3.6e-08 471473001564 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873 471473001565 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 471473001566 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 471473001567 HMMPfam hit to PF03446, NAD binding domain of 6-phosphogluconat, score 7.9e-88 471473001568 HMMPfam hit to PF00393, 6-phosphogluconate dehydrogenase, C-ter, score 8.7e-180 471473001569 PS00461 6-phosphogluconate dehydrogenase signature 471473001570 GTP-binding protein LepA; Provisional; Region: PRK05433 471473001571 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 471473001572 G1 box; other site 471473001573 putative GEF interaction site [polypeptide binding]; other site 471473001574 GTP/Mg2+ binding site [chemical binding]; other site 471473001575 Switch I region; other site 471473001576 G2 box; other site 471473001577 G3 box; other site 471473001578 Switch II region; other site 471473001579 G4 box; other site 471473001580 G5 box; other site 471473001581 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 471473001582 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 471473001583 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 471473001584 HMMPfam hit to PF06421, GTP-binding protein LepA C-terminus, score 1e-73 471473001585 HMMPfam hit to PF00679, Elongation factor G C-terminus, score 8.7e-33 471473001586 HMMPfam hit to PF03144, Elongation factor Tu domain,score 5.7e-13 471473001587 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 6.9e-71 471473001588 PS00017 ATP/GTP-binding site motif A (P-loop) 471473001589 ADP/ATP carrier protein family; Region: AAA; TIGR00769 471473001590 HMMPfam hit to PF03219, TLC ATP/ADP transporter,score 0 471473001591 11 probable transmembrane helices predicted for CTL0321 by TMHMM2.0 at aa 27-44, 59-81, 93-115,149-171,184-206, 221-243, 284-306, 321-343, 350-372,382-401 and 456-478 471473001592 PS00430 TonB-dependent receptor proteins signature 1 471473001593 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 471473001594 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 471473001595 intersubunit interface [polypeptide binding]; other site 471473001596 HMMPfam hit to PF01297, Periplasmic solute binding protein family, score 4.8e-129 471473001597 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 471473001598 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 471473001599 HMMPfam hit to PF00005, ABC transporter, score 6.7e-46 471473001600 PS00017 ATP/GTP-binding site motif A (P-loop) 471473001601 PS00211 ABC transporters family signature 471473001602 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 471473001603 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471473001604 ABC-ATPase subunit interface; other site 471473001605 dimer interface [polypeptide binding]; other site 471473001606 putative PBP binding regions; other site 471473001607 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 471473001608 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 471473001609 HMMPfam hit to PF00950, ABC 3 transport family,score 1.2e-13 471473001610 7 probable transmembrane helices predicted for CTL0325 by TMHMM2.0 at aa 12-34, 68-90, 102-120,143-165,190-212, 232-254 and 275-297 471473001611 HMMPfam hit to PF02742, Iron dependent repressor,metal binding, score 2.2e-14 471473001612 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 471473001613 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471473001614 ABC-ATPase subunit interface; other site 471473001615 dimer interface [polypeptide binding]; other site 471473001616 putative PBP binding regions; other site 471473001617 10 probable transmembrane helices predicted for CTL0326 by TMHMM2.0 at aa 5-24, 39-61, 68-90,95-114,127-144, 167-189, 202-224, 228-250, 255-277 and 287-306 471473001618 HMMPfam hit to PF00950, ABC 3 transport family,score 2.2e-11 471473001619 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 471473001620 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 471473001621 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 471473001622 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 471473001623 HMMPfam hit to PF02670, 1-deoxy-D-xylulose 5-phosphate reduct, score 5.7e-59 471473001624 HMMPfam hit to PF08436, 1-deoxy-D-xylulose 5-phosphate reduct, score 6.3e-57 471473001625 RIP metalloprotease RseP; Region: TIGR00054 471473001626 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 471473001627 active site 471473001628 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 471473001629 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 471473001630 putative substrate binding region [chemical binding]; other site 471473001631 4 probable transmembrane helices predicted for CTL0328 by TMHMM2.0 at aa 4-26, 103-125, 558-580 and 593-610 471473001632 HMMPfam hit to PF02163, Peptidase family M50, score 1e-80 471473001633 PS00142 Neutral zinc metallopeptidases,zinc-binding region signature 471473001634 PS00136 Serine proteases, subtilase family,aspartic acid active site 471473001635 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 471473001636 Putative serine esterase (DUF676); Region: DUF676; pfam05057 471473001637 recF protein; Region: recf; TIGR00611 471473001638 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471473001639 Walker A/P-loop; other site 471473001640 ATP binding site [chemical binding]; other site 471473001641 Q-loop/lid; other site 471473001642 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471473001643 ABC transporter signature motif; other site 471473001644 Walker B; other site 471473001645 HMMPfam hit to PF02463, RecF/RecN/SMC N terminal domain, score 2.3e-10 471473001646 PS00017 ATP/GTP-binding site motif A (P-loop) 471473001647 DNA polymerase III subunit beta; Validated; Region: PRK05643 471473001648 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 471473001649 putative DNA binding surface [nucleotide binding]; other site 471473001650 dimer interface [polypeptide binding]; other site 471473001651 beta-clamp/clamp loader binding surface; other site 471473001652 beta-clamp/translesion DNA polymerase binding surface; other site 471473001653 HMMPfam hit to PF02768, DNA polymerase III beta subunit, C-te, score 9.3e-08 471473001654 HMMPfam hit to PF02767, DNA polymerase III beta subunit, cent, score 3e-23 471473001655 HMMPfam hit to PF00712, DNA polymerase III beta subunit, N-te, score 5e-21 471473001656 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 471473001657 SmpB-tmRNA interface; other site 471473001658 HMMPfam hit to PF01668, SmpB protein, score 1e-26 471473001659 PS01317 Protein smpB signature 471473001660 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 471473001661 ApbE family; Region: ApbE; pfam02424 471473001662 HMMPfam hit to PF02424, ApbE family, score 3.4e-165 471473001663 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 471473001664 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14181 471473001665 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 471473001666 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 471473001667 homodimer interface [polypeptide binding]; other site 471473001668 NADP binding site [chemical binding]; other site 471473001669 substrate binding site [chemical binding]; other site 471473001670 HMMPfam hit to PF02882, Tetrahydrofolate dehydrogenase/cyclohyd, score 3.5e-102 471473001671 PS00767 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2 471473001672 HMMPfam hit to PF00763, Tetrahydrofolate dehydrogenase/cyclohyd, score 1.5e-63 471473001673 2 probable transmembrane helices predicted for CTL0335 by TMHMM2.0 at aa 20-53 and 65-87 471473001674 PS00017 ATP/GTP-binding site motif A (P-loop) 471473001675 2 probable transmembrane helices predicted for CTL0337 by TMHMM2.0 at aa 47-66 and 78-100 471473001676 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 471473001677 PLD-like domain; Region: PLDc_2; pfam13091 471473001678 putative active site [active] 471473001679 catalytic site [active] 471473001680 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 471473001681 PLD-like domain; Region: PLDc_2; pfam13091 471473001682 putative active site [active] 471473001683 catalytic site [active] 471473001684 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 0.41 471473001685 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 0.013 471473001686 1 probable transmembrane helix predicted for CTL0339 by TMHMM2.0 at aa 7-29 471473001687 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 471473001688 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 471473001689 HMMPfam hit to PF01977,3-octaprenyl-4-hydroxybenzoate carboxy-lyase, score 1.9e-220 471473001690 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 471473001691 HMMPfam hit to PF00830, Ribosomal L28 family, score 4.4e-12 471473001692 4-alpha-glucanotransferase; Region: Glyco_hydro_77; pfam02446 471473001693 HMMPfam hit to PF02446,4-alpha-glucanotransferase,score 2.8e-281 471473001694 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 471473001695 HMMPfam hit to PF05932, Tir chaperone protein (CesT), score 1.1e-36 471473001696 HrpJ-like domain; Region: HrpJ; cl15454 471473001697 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 471473001698 FHIPEP family; Region: FHIPEP; pfam00771 471473001699 HMMPfam hit to PF00771, FHIPEP family, score 0 471473001700 6 probable transmembrane helices predicted for CTL0345 by TMHMM2.0 at aa 27-44, 57-79, 119-141,208-230,245-267 and 309-331 471473001701 type III secretion system protein; Validated; Region: PRK06298 471473001702 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 471473001703 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 471473001704 HMMPfam hit to PF01312, FlhB HrpN YscU SpaS Family,score 2.2e-171 471473001705 4 probable transmembrane helices predicted for CTL0346 by TMHMM2.0 at aa 38-60, 80-102, 136-158 and 183-205 471473001706 GTP-binding protein YchF; Reviewed; Region: PRK09601 471473001707 YchF GTPase; Region: YchF; cd01900 471473001708 G1 box; other site 471473001709 GTP/Mg2+ binding site [chemical binding]; other site 471473001710 Switch I region; other site 471473001711 G2 box; other site 471473001712 Switch II region; other site 471473001713 G3 box; other site 471473001714 G4 box; other site 471473001715 G5 box; other site 471473001716 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 471473001717 PS00443 Glutamine amidotransferases class-II active site 471473001718 HMMPfam hit to PF01926, GTPase of unknown function,score 8.9e-29 471473001719 PS00017 ATP/GTP-binding site motif A (P-loop) 471473001720 HMMPfam hit to PF06071, Protein of unknown function (DUF933), score 1.2e-48 471473001721 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 471473001722 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 471473001723 active site 471473001724 Riboflavin kinase; Region: Flavokinase; smart00904 471473001725 HMMPfam hit to PF01687, Riboflavin kinase, score 4.8e-31 471473001726 HMMPfam hit to PF06574, FAD synthetase, score 1.9e-62 471473001727 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00989 471473001728 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 471473001729 RNA binding site [nucleotide binding]; other site 471473001730 active site 471473001731 HMMPfam hit to PF01509, TruB family pseudouridylate synthase (N term, score 8.2e-49 471473001732 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 471473001733 HMMPfam hit to PF02033, Ribosome-binding factor A,score 1.8e-12 471473001734 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 471473001735 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 471473001736 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 471473001737 G1 box; other site 471473001738 putative GEF interaction site [polypeptide binding]; other site 471473001739 GTP/Mg2+ binding site [chemical binding]; other site 471473001740 Switch I region; other site 471473001741 G2 box; other site 471473001742 G3 box; other site 471473001743 Switch II region; other site 471473001744 G4 box; other site 471473001745 G5 box; other site 471473001746 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 471473001747 Translation-initiation factor 2; Region: IF-2; pfam11987 471473001748 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 471473001749 HMMPfam hit to PF03144, Elongation factor Tu domain,score 1.9e-09 471473001750 PS01176 Initiation factor 2 signature 471473001751 HMMPfam hit to PF03144, Elongation factor Tu domain,score 1.2e-10 471473001752 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 5.7e-46 471473001753 PS00017 ATP/GTP-binding site motif A (P-loop) 471473001754 HMMPfam hit to PF04760, Translation initiation factor IF-2, N-ter, score 1.8e-11 471473001755 transcription termination factor NusA; Region: NusA; TIGR01953 471473001756 NusA N-terminal domain; Region: NusA_N; pfam08529 471473001757 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 471473001758 RNA binding site [nucleotide binding]; other site 471473001759 homodimer interface [polypeptide binding]; other site 471473001760 NusA-like KH domain; Region: KH_5; pfam13184 471473001761 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 471473001762 G-X-X-G motif; other site 471473001763 HMMPfam hit to PF00575, S1 RNA binding domain,score 4.8e-07 471473001764 HMMPfam hit to PF08529, NusA N-terminal domain,score 4.5e-62 471473001765 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 471473001766 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 471473001767 RNA binding site [nucleotide binding]; other site 471473001768 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 471473001769 RNA binding site [nucleotide binding]; other site 471473001770 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 471473001771 RNA binding site [nucleotide binding]; other site 471473001772 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 471473001773 RNA binding site [nucleotide binding]; other site 471473001774 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 471473001775 RNA binding site [nucleotide binding]; other site 471473001776 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 471473001777 RNA binding site [nucleotide binding]; other site 471473001778 domain interface; other site 471473001779 HMMPfam hit to PF00575, S1 RNA binding domain,score 1.2e-22 471473001780 HMMPfam hit to PF00575, S1 RNA binding domain,score 8.7e-25 471473001781 HMMPfam hit to PF00575, S1 RNA binding domain,score 1.9e-25 471473001782 HMMPfam hit to PF00575, S1 RNA binding domain,score 8.9e-22 471473001783 HMMPfam hit to PF00575, S1 RNA binding domain,score 1.6e-16 471473001784 HMMPfam hit to PF00575, S1 RNA binding domain,score 5.3e-17 471473001785 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 471473001786 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471473001787 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471473001788 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidoreduc, score 2.7e-53 471473001789 PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site 471473001790 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreduc, score 9.2e-25 471473001791 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 471473001792 HMMPfam hit to PF01648, 4'-phosphopantetheinyl transferase superfami, score 4e-27 471473001793 2 probable transmembrane helices predicted for CTL0356 by TMHMM2.0 at aa 5-22 and 32-54 471473001794 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 471473001795 1 probable transmembrane helix predicted for CTL0357 by TMHMM2.0 at aa 43-65 471473001796 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 471473001797 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 471473001798 active site 471473001799 motif I; other site 471473001800 motif II; other site 471473001801 HMMPfam hit to PF08282, haloacid dehalogenase-like hydrolase, score 4e-07 471473001802 enoyl-[acyl-carrier-protein] reductase; Region: PLN02730 471473001803 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 471473001804 NAD binding site [chemical binding]; other site 471473001805 homotetramer interface [polypeptide binding]; other site 471473001806 homodimer interface [polypeptide binding]; other site 471473001807 substrate binding site [chemical binding]; other site 471473001808 active site 471473001809 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 471473001810 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471473001811 RNA binding surface [nucleotide binding]; other site 471473001812 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 471473001813 active site 471473001814 HMMPfam hit to PF00849, RNA pseudouridylate synthase, score 2.7e-52 471473001815 PS01129 Rlu family of pseudouridine synthase signature 471473001816 HMMPfam hit to PF01479, S4 domain, score 5.4e-05 471473001817 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 471473001818 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 471473001819 minor groove reading motif; other site 471473001820 helix-hairpin-helix signature motif; other site 471473001821 substrate binding pocket [chemical binding]; other site 471473001822 active site 471473001823 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 471473001824 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 471473001825 DNA binding and oxoG recognition site [nucleotide binding] 471473001826 HMMPfam hit to PF00730, HhH-GPD superfamily base excision DNA repair, score 4.4e-22 471473001827 HMMPfam hit to PF00633, Helix-hairpin-helix motif,score 2.6e-05 471473001828 Uncharacterized conserved protein [Function unknown]; Region: COG0327 471473001829 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 471473001830 HMMPfam hit to PF01784, NIF3 (NGG1p interacting factor 3), score 2.5e-89 471473001831 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 471473001832 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 471473001833 ring oligomerisation interface [polypeptide binding]; other site 471473001834 ATP/Mg binding site [chemical binding]; other site 471473001835 stacking interactions; other site 471473001836 hinge regions; other site 471473001837 HMMPfam hit to PF00118, TCP-1/cpn60 chaperonin family, score 8.4e-187 471473001838 PS00296 Chaperonins cpn60 signature 471473001839 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 471473001840 oligomerisation interface [polypeptide binding]; other site 471473001841 mobile loop; other site 471473001842 roof hairpin; other site 471473001843 HMMPfam hit to PF00166, Chaperonin 10 Kd subunit,score 5.2e-41 471473001844 PS00681 Chaperonins cpn10 signature 471473001845 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 471473001846 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 471473001847 active site 471473001848 Zn binding site [ion binding]; other site 471473001849 HMMPfam hit to PF01432, Peptidase family M3, score 2.5e-165 471473001850 PS00017 ATP/GTP-binding site motif A (P-loop) 471473001851 HMMPfam hit to PF08439, Oligopeptidase F, score 4.8e-18 471473001852 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 471473001853 Clp amino terminal domain; Region: Clp_N; pfam02861 471473001854 Clp amino terminal domain; Region: Clp_N; pfam02861 471473001855 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471473001856 Walker A motif; other site 471473001857 ATP binding site [chemical binding]; other site 471473001858 Walker B motif; other site 471473001859 arginine finger; other site 471473001860 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471473001861 Walker A motif; other site 471473001862 ATP binding site [chemical binding]; other site 471473001863 Walker B motif; other site 471473001864 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 471473001865 HMMPfam hit to PF02861, Clp amino terminal domain,score 3e-10 471473001866 HMMPfam hit to PF02861, Clp amino terminal domain,score 6.6e-10 471473001867 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 1.4e-10 471473001868 PS00017 ATP/GTP-binding site motif A (P-loop) 471473001869 PS00870 Chaperonins clpA/B signature 1 471473001870 HMMPfam hit to PF07724, ATPase family associated with various cellul, score 1.6e-102 471473001871 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 3.2e-05 471473001872 PS00017 ATP/GTP-binding site motif A (P-loop) 471473001873 Uncharacterized conserved protein [Function unknown]; Region: COG2912 471473001874 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 471473001875 2 probable transmembrane helices predicted for CTL0370 by TMHMM2.0 at aa 51-73 and 83-105 471473001876 2 probable transmembrane helices predicted for CTL0371 by TMHMM2.0 at aa 39-61 and 65-87 471473001877 PS00044 Bacterial regulatory proteins, lysR family signature 471473001878 2 probable transmembrane helices predicted for CTL0372 by TMHMM2.0 at aa 39-60 and 70-92 471473001879 2 probable transmembrane helices predicted for CTL0373 by TMHMM2.0 at aa 34-56 and 66-88 471473001880 IncA protein; Region: IncA; pfam04156 471473001881 HMMPfam hit to PF04156, IncA protein, score 1.4e-24 471473001882 2 probable transmembrane helices predicted for CTL0374 by TMHMM2.0 at aa 12-34 and 38-57 471473001883 PS00615 C-type lectin domain signature 471473001884 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 471473001885 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 471473001886 substrate binding site [chemical binding]; other site 471473001887 hexamer interface [polypeptide binding]; other site 471473001888 metal binding site [ion binding]; metal-binding site 471473001889 HMMPfam hit to PF00834, Ribulose-phosphate 3 epimerase family, score 3.6e-82 471473001890 PS01085 Ribulose-phosphate 3-epimerase family signature 1 471473001891 elongation factor P; Provisional; Region: PRK12426 471473001892 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 471473001893 RNA binding site [nucleotide binding]; other site 471473001894 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 471473001895 RNA binding site [nucleotide binding]; other site 471473001896 HMMPfam hit to PF01132, Elongation factor P (EF-P) OB domain, score 0.00038 471473001897 PS01275 Elongation factor P signature 471473001898 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 471473001899 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 471473001900 carboxyltransferase (CT) interaction site; other site 471473001901 biotinylation site [posttranslational modification]; other site 471473001902 HMMPfam hit to PF00364, Biotin-requiring enzyme,score 1.3e-27 471473001903 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 471473001904 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471473001905 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471473001906 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 471473001907 HMMPfam hit to PF00289, Carbamoyl-phosphate synthase L chain,, score 4.2e-44 471473001908 HMMPfam hit to PF08443, RimK-like ATP-grasp domain,score 7.9e-05 471473001909 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain,, score 1.7e-94 471473001910 HMMPfam hit to PF02222, ATP-grasp domain, score 0.00089 471473001911 PS00867 Carbamoyl-phosphate synthase subdomain signature 2 471473001912 HMMPfam hit to PF02785, Biotin carboxylase C-terminal domain, score 6e-65 471473001913 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 471473001914 23S rRNA interface [nucleotide binding]; other site 471473001915 L3 interface [polypeptide binding]; other site 471473001916 HMMPfam hit to PF00572, Ribosomal protein L13,score 5.5e-49 471473001917 PS00783 Ribosomal protein L13 signature 471473001918 PS00063 Aldo/keto reductase family putative active site signature 471473001919 PS00030 Eukaryotic putative RNA-binding region RNP-1 signature 471473001920 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 471473001921 HMMPfam hit to PF00380, Ribosomal protein S9/S16,score 5.7e-48 471473001922 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 471473001923 NlpC/P60 family; Region: NLPC_P60; cl17555 471473001924 HMMPfam hit to PF00877, NlpC/P60 family, score 1.5e-08 471473001925 adenylate kinase; Reviewed; Region: adk; PRK00279 471473001926 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 471473001927 AMP-binding site [chemical binding]; other site 471473001928 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 471473001929 HMMPfam hit to PF00406, Adenylate kinase, score 5.5e-42 471473001930 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 471473001931 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471473001932 dimer interface [polypeptide binding]; other site 471473001933 conserved gate region; other site 471473001934 putative PBP binding loops; other site 471473001935 ABC-ATPase subunit interface; other site 471473001936 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 4.5e-17 471473001937 4 probable transmembrane helices predicted for CTL0384 by TMHMM2.0 at aa 15-37, 58-80, 84-103 and 187-206 471473001938 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign 471473001939 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 471473001940 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471473001941 Walker A/P-loop; other site 471473001942 ATP binding site [chemical binding]; other site 471473001943 Q-loop/lid; other site 471473001944 ABC transporter signature motif; other site 471473001945 Walker B; other site 471473001946 D-loop; other site 471473001947 H-loop/switch region; other site 471473001948 HMMPfam hit to PF00005, ABC transporter, score 7.7e-54 471473001949 PS00017 ATP/GTP-binding site motif A (P-loop) 471473001950 PS00211 ABC transporters family signature 471473001951 1 probable transmembrane helix predicted for CTL0386 by TMHMM2.0 at aa 9-31 471473001952 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 471473001953 HMMPfam hit to PF03631, Ribonuclease BN-like family,score 1.5e-05 471473001954 6 probable transmembrane helices predicted for CTL0387 by TMHMM2.0 at aa 42-64, 100-122, 143-165,185-207,219-241 and 256-278 471473001955 Methyltransferase domain; Region: Methyltransf_23; pfam13489 471473001956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471473001957 S-adenosylmethionine binding site [chemical binding]; other site 471473001958 HMMPfam hit to PF08241, Methyltransferase domain,score 5.1e-12 471473001959 HMMPfam hit to PF08242, Methyltransferase domain,score 1.7e-14 471473001960 PS01186 EGF-like domain signature 2 471473001961 2 probable transmembrane helices predicted for CTL0389 by TMHMM2.0 at aa 31-53 and 80-98 471473001962 4 probable transmembrane helices predicted for CTL0390 by TMHMM2.0 at aa 20-42, 121-143, 211-233 and 243-265 471473001963 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 471473001964 Serine hydrolase (FSH1); Region: FSH1; pfam03959 471473001965 HMMPfam hit to PF02230,Phospholipase/Carboxylesterase, score 2.2e-103 471473001966 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 471473001967 HMMPfam hit to PF01300, yrdC domain, score 1.9e-31 471473001968 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 471473001969 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471473001970 active site 471473001971 HMMPfam hit to PF01244, Membrane dipeptidase (Peptidase family, score 2.3e-13 471473001972 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 471473001973 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471473001974 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 1.6e-66 471473001975 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 471473001976 conserved hypothetical integral membrane protein; Region: TIGR00697 471473001977 7 probable transmembrane helices predicted for CTL0395 by TMHMM2.0 at aa 5-22, 29-51, 55-77,84-103,127-149, 165-187 and 192-214 471473001978 HMMPfam hit to PF02592, Uncharacterized ACR, YhhQ family COG1738, score 2.9e-67 471473001979 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 471473001980 SEC-C motif; Region: SEC-C; pfam02810 471473001981 HMMPfam hit to PF02810, SEC-C motif, score 8.3e-10 471473001982 1 probable transmembrane helix predicted for CTL0399 by TMHMM2.0 at aa 231-253 471473001983 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471473001984 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471473001985 active site 471473001986 ATP binding site [chemical binding]; other site 471473001987 substrate binding site [chemical binding]; other site 471473001988 activation loop (A-loop); other site 471473001989 Uncharacterized conserved protein [Function unknown]; Region: COG1262 471473001990 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 471473001991 HMMPfam hit to PF00069, Protein kinase domain,score 1.5e-06 471473001992 HMMPfam hit to PF03781, Domain of unknown function (DUF323), score 2.3e-103 471473001993 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 471473001994 DNA ligase, NAD-dependent; Region: dnlj; TIGR00575 471473001995 nucleotide binding pocket [chemical binding]; other site 471473001996 K-X-D-G motif; other site 471473001997 catalytic site [active] 471473001998 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 471473001999 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 471473002000 Helix-hairpin-helix motif; Region: HHH; pfam00633 471473002001 helix-hairpin-helix signature motif; other site 471473002002 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 471473002003 Dimer interface [polypeptide binding]; other site 471473002004 HMMPfam hit to PF01653, NAD-dependent DNA ligase adenylation, score 3.6e-102 471473002005 HMMPfam hit to PF03120, NAD-dependent DNA ligase OB-fold doma, score 9.5e-49 471473002006 PS01056 NAD-dependent DNA ligase signature 2 471473002007 HMMPfam hit to PF03119, NAD-dependent DNA ligase C4 zinc fing, score 1.6e-08 471473002008 HMMPfam hit to PF00633, Helix-hairpin-helix motif,score 4.4e-08 471473002009 HMMPfam hit to PF00533, BRCA1 C Terminus (BRCT) domain, score 1.3e-17 471473002010 4 probable transmembrane helices predicted for CTL0402 by TMHMM2.0 at aa 76-98, 100-122, 848-870 and 877-899 471473002011 hypothetical protein; Provisional; Region: PRK06184 471473002012 HMMPfam hit to PF01494, FAD binding domain, score 9.2e-05 471473002013 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 471473002014 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 471473002015 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 471473002016 HMMPfam hit to PF00471, Ribosomal protein L33,score 2.8e-14 471473002017 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 471473002018 FtsX-like permease family; Region: FtsX; pfam02687 471473002019 4 probable transmembrane helices predicted for CTL0406 by TMHMM2.0 at aa 21-43, 364-386, 407-429 and 464-486 471473002020 HMMPfam hit to PF02687, Predicted permease, score 3.7e-40 471473002021 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471473002022 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471473002023 Walker A/P-loop; other site 471473002024 ATP binding site [chemical binding]; other site 471473002025 Q-loop/lid; other site 471473002026 ABC transporter signature motif; other site 471473002027 Walker B; other site 471473002028 D-loop; other site 471473002029 H-loop/switch region; other site 471473002030 HMMPfam hit to PF00005, ABC transporter, score 7.7e-55 471473002031 PS00017 ATP/GTP-binding site motif A (P-loop) 471473002032 PS00211 ABC transporters family signature 471473002033 membrane-attack complex / perforin; Region: MACPF; smart00457 471473002034 Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases; Region: MIR; smart00472 471473002035 HMMPfam hit to PF01823, MAC/Perforin domain, score 1.1e-63 471473002036 The sequence has been checked and is believed to be correct 471473002037 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 0.55 471473002038 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 2 471473002039 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 471473002040 PLD-like domain; Region: PLDc_2; pfam13091 471473002041 putative active site [active] 471473002042 catalytic site [active] 471473002043 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 471473002044 PLD-like domain; Region: PLDc_2; pfam13091 471473002045 putative active site [active] 471473002046 catalytic site [active] 471473002047 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 1.6 471473002048 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 0.009 471473002049 indel in L2 and Harl13: acgattccg 471473002050 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 471473002051 PLD-like domain; Region: PLDc_2; pfam13091 471473002052 putative active site [active] 471473002053 catalytic site [active] 471473002054 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 471473002055 PLD-like domain; Region: PLDc_2; pfam13091 471473002056 putative active site [active] 471473002057 catalytic site [active] 471473002058 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 1.3 471473002059 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 0.026 471473002060 The sequence has been checked and is believed to be correct 471473002061 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 2.3 471473002062 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 0.00026 471473002063 The sequence has been checked and is believed to be correct 471473002064 The sequence has been checked and is believed to be correct 471473002065 1 probable transmembrane helix predicted for CTL0418 by TMHMM2.0 at aa 47-69 471473002066 1 probable transmembrane helix predicted for CTL0419 by TMHMM2.0 at aa 63-85 471473002067 HMMPfam hit to PF00612, IQ calmodulin-binding motif,score 0.00048 471473002068 PS00018 EF-hand calcium-binding domain 471473002069 1 probable transmembrane helix predicted for CTL0419A by TMHMM2.0 at aa 31-53 471473002070 Trp repressor protein; Region: Trp_repressor; cl17266 471473002071 HMMPfam hit to PF01371, Trp repressor protein,score 6.9e-41 471473002072 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 471473002073 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 471473002074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471473002075 catalytic residue [active] 471473002076 HMMPfam hit to PF00291, Pyridoxal-phosphate dependent enzyme, score 5.7e-121 471473002077 PS00168 Tryptophan synthase beta chain pyridoxal-phosphate attachment site 471473002078 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 471473002079 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 471473002080 substrate binding site [chemical binding]; other site 471473002081 active site 471473002082 catalytic residues [active] 471473002083 heterodimer interface [polypeptide binding]; other site 471473002084 HMMPfam hit to PF00290, Tryptophan synthase alpha chain, score 2.4e-19 471473002085 The sequence has been checked and is believed to be correct 471473002086 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 471473002087 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 471473002088 peptide binding site [polypeptide binding]; other site 471473002089 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 471473002090 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 3.5e-70 471473002091 putative disulfide oxidoreductase; Provisional; Region: PRK00611 471473002092 HMMPfam hit to PF02600, Disulfide bond formation protein DsbB, score 2.3e-64 471473002093 4 probable transmembrane helices predicted for CTL0428 by TMHMM2.0 at aa 7-29, 39-58, 71-93 and 108-130 471473002094 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 471473002095 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 471473002096 Thioredoxin; Region: Thioredoxin_4; cl17273 471473002097 1 probable transmembrane helix predicted for CTL0429 by TMHMM2.0 at aa 12-29 471473002098 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729 471473002099 putative active site [active] 471473002100 redox center [active] 471473002101 10 probable transmembrane helices predicted for CTL0430 by TMHMM2.0 at aa 17-39, 54-76, 89-111,141-163,170-192, 202-224, 303-325, 335-352, 359-381 and 385-402 471473002102 2 probable transmembrane helices predicted for CTL0431 by TMHMM2.0 at aa 2-24 and 29-51 471473002103 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 471473002104 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471473002105 Walker A/P-loop; other site 471473002106 ATP binding site [chemical binding]; other site 471473002107 Q-loop/lid; other site 471473002108 ABC transporter signature motif; other site 471473002109 Walker B; other site 471473002110 D-loop; other site 471473002111 H-loop/switch region; other site 471473002112 HMMPfam hit to PF00005, ABC transporter, score 3.2e-40 471473002113 PS00211 ABC transporters family signature 471473002114 PS00017 ATP/GTP-binding site motif A (P-loop) 471473002115 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 471473002116 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 471473002117 Ligand binding site; other site 471473002118 oligomer interface; other site 471473002119 HMMPfam hit to PF02348, Cytidylyltransferase, score 7.6e-94 471473002120 CTP synthetase; Validated; Region: pyrG; PRK05380 471473002121 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 471473002122 Catalytic site [active] 471473002123 active site 471473002124 UTP binding site [chemical binding]; other site 471473002125 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 471473002126 active site 471473002127 putative oxyanion hole; other site 471473002128 catalytic triad [active] 471473002129 HMMPfam hit to PF06418, CTP synthase N-terminus,score 5.6e-192 471473002130 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 7.2e-73 471473002131 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 471473002132 HMMPfam hit to PF03652, Uncharacterised protein family (UPF0081), score 7.6e-60 471473002133 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 471473002134 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 471473002135 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 471473002136 HMMPfam hit to PF00479, Glucose-6-phosphate dehydrogenase, NAD bindi, score 2.6e-47 471473002137 PS00069 Glucose-6-phosphate dehydrogenase active site 471473002138 HMMPfam hit to PF02781, Glucose-6-phosphate dehydrogenase, C-termina, score 3e-125 471473002139 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 471473002140 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 471473002141 putative active site [active] 471473002142 DNA polymerase III subunit delta'; Validated; Region: PRK05917 471473002143 DNA polymerase III subunit delta'; Validated; Region: PRK08485 471473002144 thymidylate kinase; Validated; Region: tmk; PRK00698 471473002145 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 471473002146 TMP-binding site; other site 471473002147 ATP-binding site [chemical binding]; other site 471473002148 HMMPfam hit to PF02223, Thymidylate kinase, score 8.7e-86 471473002149 PS01331 Thymidylate kinase signature 471473002150 PS00017 ATP/GTP-binding site motif A (P-loop) 471473002151 DNA gyrase, A subunit; Region: gyrA; TIGR01063 471473002152 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 471473002153 CAP-like domain; other site 471473002154 active site 471473002155 primary dimer interface [polypeptide binding]; other site 471473002156 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471473002157 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471473002158 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471473002159 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471473002160 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471473002161 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471473002162 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 1.1e-11 471473002163 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 2.5e-10 471473002164 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 1.1e-15 471473002165 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 1.6e-09 471473002166 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 1.9e-11 471473002167 HMMPfam hit to PF03989, DNA gyrase C-terminal domain, beta-prop, score 3.7e-11 471473002168 HMMPfam hit to PF00521, DNA gyrase/topoisomerase IV,subunit A, score 6.6e-300 471473002169 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 471473002170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471473002171 ATP binding site [chemical binding]; other site 471473002172 Mg2+ binding site [ion binding]; other site 471473002173 G-X-G motif; other site 471473002174 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 471473002175 anchoring element; other site 471473002176 dimer interface [polypeptide binding]; other site 471473002177 ATP binding site [chemical binding]; other site 471473002178 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 471473002179 active site 471473002180 putative metal-binding site [ion binding]; other site 471473002181 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 471473002182 HMMPfam hit to PF00986, DNA gyrase B subunit,carboxyl terminus, score 1.4e-44 471473002183 HMMPfam hit to PF01751, Toprim domain, score 1.2e-10 471473002184 PS00177 DNA topoisomerase II signature 471473002185 HMMPfam hit to PF00204, DNA gyrase B, score 1.6e-91 471473002186 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and H, score 1.5e-27 471473002187 Protein of unknown function (DUF721); Region: DUF721; pfam05258 471473002188 2 probable transmembrane helices predicted for CTL0444 by TMHMM2.0 at aa 33-55 and 60-82 471473002189 queuine tRNA-ribosyltransferase; Provisional; Region: PRK01008 471473002190 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 471473002191 HMMPfam hit to PF01702, Queuine tRNA-ribosyltransferase, score 1.3e-54 471473002192 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 471473002193 MgtE intracellular N domain; Region: MgtE_N; pfam03448 471473002194 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 471473002195 Divalent cation transporter; Region: MgtE; pfam01769 471473002196 5 probable transmembrane helices predicted for CTL0446 by TMHMM2.0 at aa 291-313, 320-342, 375-397,409-431 and 451-469 471473002197 HMMPfam hit to PF01769, Divalent cation transporter,score 1.8e-54 471473002198 HMMPfam hit to PF00571, CBS domain pair, score 7.7e-17 471473002199 HMMPfam hit to PF03448, MgtE intracellular domain,score 3.1e-32 471473002200 3 probable transmembrane helices predicted for CTL0447 by TMHMM2.0 at aa 53-75, 85-107 and 175-197 471473002201 2 probable transmembrane helices predicted for CTL0448 by TMHMM2.0 at aa 34-56 and 63-85 471473002202 UGMP family protein; Validated; Region: PRK09604 471473002203 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 471473002204 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 471473002205 HMMPfam hit to PF00814, Glycoprotease family, score 4.4e-69 471473002206 PS01016 Glycoprotease family signature 471473002207 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 471473002208 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 471473002209 peptide binding site [polypeptide binding]; other site 471473002210 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 471473002211 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 7.7e-67 471473002212 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471473002213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471473002214 dimer interface [polypeptide binding]; other site 471473002215 conserved gate region; other site 471473002216 putative PBP binding loops; other site 471473002217 ABC-ATPase subunit interface; other site 471473002218 7 probable transmembrane helices predicted for CTL0451 by TMHMM2.0 at aa 9-31, 102-124, 133-155,175-197,218-240, 245-264 and 277-299 471473002219 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 2.2e-42 471473002220 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 471473002221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471473002222 dimer interface [polypeptide binding]; other site 471473002223 conserved gate region; other site 471473002224 putative PBP binding loops; other site 471473002225 ABC-ATPase subunit interface; other site 471473002226 6 probable transmembrane helices predicted for CTL0452 by TMHMM2.0 at aa 19-41, 80-102, 122-141,145-167,191-213 and 241-263 471473002227 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 5.1e-37 471473002228 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471473002229 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 471473002230 Walker A/P-loop; other site 471473002231 ATP binding site [chemical binding]; other site 471473002232 Q-loop/lid; other site 471473002233 ABC transporter signature motif; other site 471473002234 Walker B; other site 471473002235 D-loop; other site 471473002236 H-loop/switch region; other site 471473002237 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 471473002238 HMMPfam hit to PF00005, ABC transporter, score 1.5e-49 471473002239 PS00017 ATP/GTP-binding site motif A (P-loop) 471473002240 PS00211 ABC transporters family signature 471473002241 HMMPfam hit to PF08352, Oligopeptide/dipeptide transporter, C-termi, score 8.6e-06 471473002242 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 471473002243 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471473002244 Walker A/P-loop; other site 471473002245 ATP binding site [chemical binding]; other site 471473002246 Q-loop/lid; other site 471473002247 ABC transporter signature motif; other site 471473002248 Walker B; other site 471473002249 D-loop; other site 471473002250 H-loop/switch region; other site 471473002251 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471473002252 HMMPfam hit to PF00005, ABC transporter, score 2.8e-55 471473002253 PS00017 ATP/GTP-binding site motif A (P-loop) 471473002254 PS00211 ABC transporters family signature 471473002255 Protein of unknown function (DUF1186); Region: DUF1186; pfam06685 471473002256 HMMPfam hit to PF06685, Protein of unknown function (DUF1186), score 8.3e-194 471473002257 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 471473002258 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 471473002259 transmembrane helices; other site 471473002260 HMMPfam hit to PF00939, Sodium:sulfate symporter transmembrane, score 9.2e-275 471473002261 10 probable transmembrane helices predicted for CTL0456 by TMHMM2.0 at aa 7-29, 44-66, 120-142,178-200,213-235, 281-303, 324-346, 361-378, 390-412 and 445-467 471473002262 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 471473002263 active site 471473002264 ADP/pyrophosphate binding site [chemical binding]; other site 471473002265 dimerization interface [polypeptide binding]; other site 471473002266 allosteric effector site; other site 471473002267 fructose-1,6-bisphosphate binding site; other site 471473002268 HMMPfam hit to PF00365, Phosphofructokinase, score 1.1e-09 471473002269 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 471473002270 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471473002271 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 471473002272 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 471473002273 active site 471473002274 ADP/pyrophosphate binding site [chemical binding]; other site 471473002275 dimerization interface [polypeptide binding]; other site 471473002276 allosteric effector site; other site 471473002277 fructose-1,6-bisphosphate binding site; other site 471473002278 HMMPfam hit to PF00365, Phosphofructokinase, score 5e-08 471473002279 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 471473002280 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 471473002281 PS00017 ATP/GTP-binding site motif A (P-loop) 471473002282 HMMPfam hit to PF04413,3-Deoxy-D-manno-octulosonic-acid tran, score 1.6e-102 471473002283 1 probable transmembrane helix predicted for CTL0460 by TMHMM2.0 at aa 5-27 471473002284 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 471473002285 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 471473002286 HIGH motif; other site 471473002287 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 471473002288 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471473002289 active site 471473002290 KMSKS motif; other site 471473002291 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 471473002292 tRNA binding surface [nucleotide binding]; other site 471473002293 HMMPfam hit to PF08264, Anticodon-binding domain,score 3e-07 471473002294 HMMPfam hit to PF00133, tRNA synthetases class I (I,L, M and V), score 9.4e-13 471473002295 PS00178 Aminoacyl-transfer RNA synthetases class-I signature 471473002296 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00615 471473002297 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471473002298 inhibitor-cofactor binding pocket; inhibition site 471473002299 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471473002300 catalytic residue [active] 471473002301 HMMPfam hit to PF00202, Aminotransferase class-III,score 1.2e-48 471473002302 PS00435 Peroxidases proximal heme-ligand signature 471473002303 Putative transcriptional regulator [Transcription]; Region: COG1678 471473002304 HMMPfam hit to PF02622, Uncharacterized ACR,COG1678,score 3.8e-88 471473002305 Uncharacterized conserved protein [Function unknown]; Region: COG1259 471473002306 HMMPfam hit to PF02577, Uncharacterised ACR,COG1259,score 2.5e-85 471473002307 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 471473002308 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471473002309 active site 471473002310 dimer interface [polypeptide binding]; other site 471473002311 HMMPfam hit to PF06026, Ribose 5-phosphate isomerase A (phosph, score 7.7e-85 471473002312 2 probable transmembrane helices predicted for CTL0466 by TMHMM2.0 at aa 36-58 and 68-90 471473002313 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 471473002314 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 471473002315 putative active site; other site 471473002316 catalytic residue [active] 471473002317 HMMPfam hit to PF01791, DeoC/LacD family aldolase,score 6.3e-58 471473002318 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 471473002319 12 probable transmembrane helices predicted for CTL0468 by TMHMM2.0 at aa 7-26, 41-63, 83-105,120-142,149-171, 191-210, 231-253, 277-299, 328-350,357-379,400-422 and 437-459 471473002320 HMMPfam hit to PF00324, Amino acid permease, score 1.2e-05 471473002321 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 471473002322 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 471473002323 Ligand Binding Site [chemical binding]; other site 471473002324 HMMPfam hit to PF01171, PP-loop family, score 4.2e-08 471473002325 Predicted acid phosphatase [General function prediction only]; Region: SurE; COG0496 471473002326 HMMPfam hit to PF01975, Survival protein SurE,score 5.9e-105 471473002327 PS00063 Aldo/keto reductase family putative active site signature 471473002328 prenyltransferase; Reviewed; Region: ubiA; PRK12876 471473002329 UbiA prenyltransferase family; Region: UbiA; pfam01040 471473002330 HMMPfam hit to PF01040, UbiA prenyltransferase family, score 3.4e-71 471473002331 9 probable transmembrane helices predicted for CTL0471 by TMHMM2.0 at aa 21-43, 48-70, 90-109,113-135,140-162, 166-185, 216-238, 242-264 and 277-299 471473002332 aromatic acid decarboxylase; Validated; Region: PRK05920 471473002333 Flavoprotein; Region: Flavoprotein; pfam02441 471473002334 HMMPfam hit to PF02441, Flavoprotein, score 1.6e-47 471473002335 1 probable transmembrane helix predicted for CTL0472 by TMHMM2.0 at aa 5-27 471473002336 Uncharacterized conserved protein [Function unknown]; Region: COG1284 471473002337 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 471473002338 6 probable transmembrane helices predicted for CTL0473 by TMHMM2.0 at aa 20-39, 54-76, 83-105,125-142,163-185 and 190-212 471473002339 HMMPfam hit to PF02588, Uncharacterized BCR, YitT family COG1284, score 7.5e-20 471473002340 HMMPfam hit to PF02588, Uncharacterized BCR, YitT family COG1284, score 1e-18 471473002341 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 471473002342 HMMPfam hit to PF04156, IncA protein, score 2.1e-11 471473002343 2 probable transmembrane helices predicted for CTL0475 by TMHMM2.0 at aa 39-61 and 66-88 471473002344 IncA protein; Region: IncA; pfam04156 471473002345 HMMPfam hit to PF04156, IncA protein, score 1.1e-38 471473002346 2 probable transmembrane helices predicted for CTL0476 by TMHMM2.0 at aa 38-60 and 67-89 471473002347 IncA protein; Region: IncA; pfam04156 471473002348 2 probable transmembrane helices predicted for CTL0477 by TMHMM2.0 at aa 35-57 and 62-84 471473002349 2 probable transmembrane helices predicted for CTL0477A by TMHMM2.0 at aa 13-35 and 45-67 471473002350 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 471473002351 2 probable transmembrane helices predicted for CTL0478 by TMHMM2.0 at aa 40-62 and 72-94 471473002352 2 probable transmembrane helices predicted for CTL0479 by TMHMM2.0 at aa 36-58 and 68-90 471473002353 IncA protein; Region: IncA; pfam04156 471473002354 HMMPfam hit to PF04156, IncA protein, score 1.3e-41 471473002355 2 probable transmembrane helices predicted for CTL0480 by TMHMM2.0 at aa 37-59 and 64-86 471473002356 HMMPfam hit to PF04156, IncA protein, score 1.7e-38 471473002357 2 probable transmembrane helices predicted for CTL0481 by TMHMM2.0 at aa 43-65 and 69-91 471473002358 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 471473002359 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 471473002360 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter family, score 1.4e-10 471473002361 9 probable transmembrane helices predicted for CTL0482 by TMHMM2.0 at aa 21-43, 53-70, 83-105,146-164,177-199, 219-241, 292-314, 329-351 and 356-378 471473002362 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 471473002363 Na2 binding site [ion binding]; other site 471473002364 putative substrate binding site 1 [chemical binding]; other site 471473002365 Na binding site 1 [ion binding]; other site 471473002366 putative substrate binding site 2 [chemical binding]; other site 471473002367 12 probable transmembrane helices predicted for CTL0483 by TMHMM2.0 at aa 7-29, 44-66, 87-109,138-157,170-189, 245-267, 279-301, 316-338, 351-373,378-400,420-442 and 457-479 471473002368 HMMPfam hit to PF00209, Sodium:neurotransmitter symporter family, score 2.2e-11 471473002369 2 probable transmembrane helices predicted for CTL0484 by TMHMM2.0 at aa 30-52 and 67-89 471473002370 2 probable transmembrane helices predicted for CTL0485 by TMHMM2.0 at aa 110-132 and 142-164 471473002371 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471473002372 putative substrate translocation pore; other site 471473002373 11 probable transmembrane helices predicted for CTL0486 by TMHMM2.0 at aa 28-47, 62-84, 93-115,125-146,159-177, 187-206, 241-263, 283-302, 309-331,394-416 and 670-692 471473002374 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 471473002375 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471473002376 ligand binding site [chemical binding]; other site 471473002377 flexible hinge region; other site 471473002378 HMMPfam hit to PF00027, Cyclic nucleotide-binding domain, score 1.7e-21 471473002379 acyl carrier protein; Provisional; Region: acpP; PRK00982 471473002380 HMMPfam hit to PF00550, Phosphopantetheine attachment site, score 3.8e-18 471473002381 PS00012 Phosphopantetheine attachment site 471473002382 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 471473002383 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 471473002384 NAD(P) binding site [chemical binding]; other site 471473002385 homotetramer interface [polypeptide binding]; other site 471473002386 homodimer interface [polypeptide binding]; other site 471473002387 active site 471473002388 HMMPfam hit to PF00106, short chain dehydrogenase,score 2.7e-38 471473002389 PS00061 Short-chain dehydrogenases/reductases family signature 471473002390 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 471473002391 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 471473002392 HMMPfam hit to PF00698, Acyl transferase domain,score 2.4e-10 471473002393 3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747 471473002394 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 471473002395 dimer interface [polypeptide binding]; other site 471473002396 active site 471473002397 CoA binding pocket [chemical binding]; other site 471473002398 HMMPfam hit to PF08541,3-Oxoacyl-[acyl-carrier-protein (ACP)], score 4.4e-40 471473002399 HMMPfam hit to PF08545,3-Oxoacyl-[acyl-carrier-protein (ACP)], score 5.2e-38 471473002400 recombination protein RecR; Region: recR; TIGR00615 471473002401 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 471473002402 putative active site [active] 471473002403 putative metal-binding site [ion binding]; other site 471473002404 tetramer interface [polypeptide binding]; other site 471473002405 HMMPfam hit to PF01751, Toprim domain, score 1.8e-14 471473002406 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 471473002407 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 471473002408 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 471473002409 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 471473002410 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 471473002411 Surface antigen; Region: Bac_surface_Ag; pfam01103 471473002412 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 5.1e-17 471473002413 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 2.4e-12 471473002414 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 3.8e-12 471473002415 HMMPfam hit to PF07244, Surface antigen variable number repeat, score 1.2e-13 471473002416 HMMPfam hit to PF01103, Surface antigen, score 8e-30 471473002417 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 471473002418 HMMPfam hit to PF03938, Outer membrane protein (OmpH-like), score 1.5e-35 471473002419 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 471473002420 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 471473002421 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 471473002422 trimer interface [polypeptide binding]; other site 471473002423 active site 471473002424 UDP-GlcNAc binding site [chemical binding]; other site 471473002425 lipid binding site [chemical binding]; lipid-binding site 471473002426 HMMPfam hit to PF04613,UDP-3-O-[3-hydroxymyristoyl] glucosamine N-a, score 1e-43 471473002427 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 1.3 471473002428 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.47 471473002429 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 1.3 471473002430 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.025 471473002431 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.076 471473002432 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 15 471473002433 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 18 471473002434 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.69 471473002435 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 471473002436 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 471473002437 tetramer interface [polypeptide binding]; other site 471473002438 TPP-binding site [chemical binding]; other site 471473002439 heterodimer interface [polypeptide binding]; other site 471473002440 phosphorylation loop region [posttranslational modification] 471473002441 HMMPfam hit to PF00676, Dehydrogenase E1 component,score 6.6e-72 471473002442 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 471473002443 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 471473002444 alpha subunit interface [polypeptide binding]; other site 471473002445 TPP binding site [chemical binding]; other site 471473002446 heterodimer interface [polypeptide binding]; other site 471473002447 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471473002448 HMMPfam hit to PF02779, Transketolase, pyridine binding domai, score 3.7e-73 471473002449 HMMPfam hit to PF02780, Transketolase, C-terminal domain, score 1.9e-55 471473002450 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 471473002451 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471473002452 E3 interaction surface; other site 471473002453 lipoyl attachment site [posttranslational modification]; other site 471473002454 e3 binding domain; Region: E3_binding; pfam02817 471473002455 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 471473002456 HMMPfam hit to PF00364, Biotin-requiring enzyme,score 1.6e-14 471473002457 HMMPfam hit to PF02817, e3 binding domain, score 5.9e-19 471473002458 HMMPfam hit to PF00198, 2-oxoacid dehydrogenases acyltransferas, score 3.1e-113 471473002459 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 471473002460 homodimer interface [polypeptide binding]; other site 471473002461 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 471473002462 active site pocket [active] 471473002463 HMMPfam hit to PF00343, Carbohydrate phosphorylase,score 0 471473002464 PS00102 Phosphorylase pyridoxal-phosphate attachment site 471473002465 2 probable transmembrane helices predicted for CTL0500A by TMHMM2.0 at aa 51-73 and 77-99 471473002466 chromosomal replication initiation protein; Provisional; Region: PRK12422 471473002467 DnaA N-terminal domain; Region: DnaA_N; pfam11638 471473002468 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471473002469 Walker A motif; other site 471473002470 ATP binding site [chemical binding]; other site 471473002471 Walker B motif; other site 471473002472 arginine finger; other site 471473002473 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 471473002474 DnaA box-binding interface [nucleotide binding]; other site 471473002475 HMMPfam hit to PF08299, Bacterial dnaA protein helix-turn-helix, score 2.1e-24 471473002476 HMMPfam hit to PF00308, Bacterial dnaA protein,score 6.2e-40 471473002477 PS00017 ATP/GTP-binding site motif A (P-loop) 471473002478 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01001 471473002479 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 471473002480 HMMPfam hit to PF02096, 60Kd inner membrane protein,score 1.9e-114 471473002481 5 probable transmembrane helices predicted for CTL0503 by TMHMM2.0 at aa 7-26, 566-588, 633-655, 686-708 and 734-756 471473002482 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 471473002483 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 471473002484 HMMPfam hit to PF01790, Prolipoprotein diacylglyceryl transferase, score 2.4e-91 471473002485 7 probable transmembrane helices predicted for CTL0504 by TMHMM2.0 at aa 20-42, 62-84, 94-116,129-151,184-203, 210-232 and 247-269 471473002486 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 471473002487 CAAX protease self-immunity; Region: Abi; pfam02517 471473002488 6 probable transmembrane helices predicted for CTL0506 by TMHMM2.0 at aa 4-25, 32-54, 69-91,112-134,158-180 and 208-230 471473002489 HMMPfam hit to PF02517, CAAX amino terminal protease family, score 1.1e-30 471473002490 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 471473002491 homodimer interface [polypeptide binding]; other site 471473002492 metal binding site [ion binding]; metal-binding site 471473002493 HMMPfam hit to PF03819, MazG nucleotide pyrophosphohydrolase domain, score 4.7e-26 471473002494 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 471473002495 Domain of unknown function DUF21; Region: DUF21; pfam01595 471473002496 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471473002497 Transporter associated domain; Region: CorC_HlyC; smart01091 471473002498 HMMPfam hit to PF01595, Domain of unknown function DUF21, score 2.7e-38 471473002499 3 probable transmembrane helices predicted for CTL0508 by TMHMM2.0 at aa 5-27, 52-74 and 81-103 471473002500 HMMPfam hit to PF00571, CBS domain pair, score 7.5e-09 471473002501 HMMPfam hit to PF03471, Transporter associated domain, score 1.3e-22 471473002502 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 471473002503 Domain of unknown function DUF21; Region: DUF21; pfam01595 471473002504 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471473002505 Transporter associated domain; Region: CorC_HlyC; smart01091 471473002506 3 probable transmembrane helices predicted for CTL0509 by TMHMM2.0 at aa 7-29, 95-114 and 135-157 471473002507 HMMPfam hit to PF01595, Domain of unknown function DUF21, score 8.1e-47 471473002508 HMMPfam hit to PF00571, CBS domain pair, score 5.1e-11 471473002509 HMMPfam hit to PF03471, Transporter associated domain, score 2.7e-15 471473002510 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 471473002511 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 471473002512 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471473002513 catalytic residue [active] 471473002514 HMMPfam hit to PF01041, DegT/DnrJ/EryC1/StrS aminotransferase, score 0.00014 471473002515 HMMPfam hit to PF00266, Aminotransferase class-V,score 2.2e-31 471473002516 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 471473002517 Protein phosphatase 2C; Region: PP2C; pfam00481 471473002518 active site 471473002519 HMMPfam hit to PF00481, Protein phosphatase 2C,score 0.0001 471473002520 Uncharacterized conserved protein [Function unknown]; Region: COG5465 471473002521 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 471473002522 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 471473002523 active site 471473002524 catalytic site [active] 471473002525 substrate binding site [chemical binding]; other site 471473002526 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 471473002527 HMMPfam hit to PF00929, Exonuclease, score 5e-54 471473002528 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign 471473002529 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 471473002530 HMMPfam hit to PF02642, Uncharacterized ACR,COG2107,score 2.5e-180 471473002531 nucleosidase; Provisional; Region: PRK05634 471473002532 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471473002533 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471473002534 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471473002535 Walker A/P-loop; other site 471473002536 ATP binding site [chemical binding]; other site 471473002537 Q-loop/lid; other site 471473002538 ABC transporter signature motif; other site 471473002539 Walker B; other site 471473002540 D-loop; other site 471473002541 H-loop/switch region; other site 471473002542 HMMPfam hit to PF00005, ABC transporter, score 1.9e-51 471473002543 PS00211 ABC transporters family signature 471473002544 PS00017 ATP/GTP-binding site motif A (P-loop) 471473002545 HMMPfam hit to PF00664, ABC transporter transmembrane region, score 9.3e-06 471473002546 5 probable transmembrane helices predicted for CTL0516 by TMHMM2.0 at aa 20-42, 125-147, 195-217, 221-243 and 312-334 471473002547 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 471473002548 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 471473002549 PS00070 Aldehyde dehydrogenases cysteine active site 471473002550 HMMPfam hit to PF03255, Acetyl co-enzyme A carboxylase carboxyltrans, score 1.4e-93 471473002551 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 471473002552 IHF - DNA interface [nucleotide binding]; other site 471473002553 IHF dimer interface [polypeptide binding]; other site 471473002554 HMMPfam hit to PF00216, Bacterial DNA-binding protein, score 2.7e-33 471473002555 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 471473002556 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 471473002557 active site 471473002558 metal binding site [ion binding]; metal-binding site 471473002559 HMMPfam hit to PF01520, N-acetylmuramoyl-L-alanine amidase, score 9.3e-89 471473002560 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 471473002561 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 471473002562 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471473002563 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471473002564 HMMPfam hit to PF02875, Mur ligase family,glutamate ligase doma, score 1.4e-28 471473002565 HMMPfam hit to PF08245, Mur ligase middle domain,score 6.5e-75 471473002566 PS01011 Folylpolyglutamate synthase signature 1 471473002567 HMMPfam hit to PF01225, Mur ligase family,catalytic domain, score 6.6e-14 471473002568 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 471473002569 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 471473002570 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 471473002571 HMMPfam hit to PF00905, Penicillin binding protein transpeptid, score 6.2e-48 471473002572 PS00017 ATP/GTP-binding site motif A (P-loop) 471473002573 HMMPfam hit to PF03717, Penicillin-binding Protein dimerisatio, score 2.5e-29 471473002574 1 probable transmembrane helix predicted for CTL0522 by TMHMM2.0 at aa 7-26 471473002575 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 471473002576 MraW methylase family; Region: Methyltransf_5; pfam01795 471473002577 HMMPfam hit to PF01795, MraW methylase family,score 1.8e-172 471473002578 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471473002579 TPR motif; other site 471473002580 binding surface 471473002581 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 471473002582 DnaA N-terminal domain; Region: DnaA_N; pfam11638 471473002583 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471473002584 Walker A motif; other site 471473002585 ATP binding site [chemical binding]; other site 471473002586 Walker B motif; other site 471473002587 arginine finger; other site 471473002588 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 471473002589 DnaA box-binding interface [nucleotide binding]; other site 471473002590 HMMPfam hit to PF00308, Bacterial dnaA protein,score 1.6e-101 471473002591 PS00017 ATP/GTP-binding site motif A (P-loop) 471473002592 HMMPfam hit to PF08299, Bacterial dnaA protein helix-turn-helix, score 1.1e-26 471473002593 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 471473002594 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 471473002595 HMMPfam hit to PF04519, Protein of unknown function,DUF583, score 2.7e-45 471473002596 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK01024 471473002597 HMMPfam hit to PF03116, NQR2, RnfD, RnfE family,score 0 471473002598 8 probable transmembrane helices predicted for CTL0530 by TMHMM2.0 at aa 57-79, 120-142, 155-177,356-378,385-407, 417-436, 449-468 and 473-495 471473002599 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 471473002600 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 471473002601 1 probable transmembrane helix predicted for CTL0531 by TMHMM2.0 at aa 13-35 471473002602 HMMPfam hit to PF04205, FMN-binding domain, score 4.9e-24 471473002603 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD [Energy production and conversion]; Region: NqrD; COG1347 471473002604 HMMPfam hit to PF02508, Rnf-Nqr subunit, membrane protein, score 2.3e-94 471473002605 6 probable transmembrane helices predicted for CTL0532 by TMHMM2.0 at aa 13-35, 40-62, 69-86,92-114,141-163 and 183-205 471473002606 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK01061 471473002607 HMMPfam hit to PF02508, Rnf-Nqr subunit, membrane protein, score 7.3e-111 471473002608 6 probable transmembrane helices predicted for CTL0533 by TMHMM2.0 at aa 13-35, 48-70, 90-112,119-141,151-173 and 186-208 471473002609 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 471473002610 lipoyl attachment site [posttranslational modification]; other site 471473002611 HMMPfam hit to PF01597, Glycine cleavage H-protein,score 3.5e-12 471473002612 HMMPfam hit to PF00364, Biotin-requiring enzyme,score 0.00088 471473002613 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site 471473002614 Chlamydial GcvH-like protein upstream region protein; Region: near_not_gcvH; TIGR03076 471473002615 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 471473002616 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 471473002617 putative active site [active] 471473002618 catalytic site [active] 471473002619 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 471473002620 putative active site [active] 471473002621 catalytic site [active] 471473002622 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 0.062 471473002623 HMMPfam hit to PF00614, Phospholipase D Active site motif, score 0.25 471473002624 1 probable transmembrane helix predicted for CTL0536 by TMHMM2.0 at aa 9-28 471473002625 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 471473002626 HMMPfam hit to PF03099, Biotin/lipoate A/B protein ligase famil, score 2.3e-19 471473002627 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 471473002628 Clp amino terminal domain; Region: Clp_N; pfam02861 471473002629 Clp amino terminal domain; Region: Clp_N; pfam02861 471473002630 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471473002631 Walker A motif; other site 471473002632 ATP binding site [chemical binding]; other site 471473002633 Walker B motif; other site 471473002634 arginine finger; other site 471473002635 UvrB/uvrC motif; Region: UVR; pfam02151 471473002636 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471473002637 Walker A motif; other site 471473002638 ATP binding site [chemical binding]; other site 471473002639 Walker B motif; other site 471473002640 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 471473002641 HMMPfam hit to PF02861, Clp amino terminal domain,score 2e-18 471473002642 PS00307 Legume lectins beta-chain signature 471473002643 HMMPfam hit to PF02861, Clp amino terminal domain,score 5.5e-18 471473002644 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 4.1e-10 471473002645 PS00017 ATP/GTP-binding site motif A (P-loop) 471473002646 HMMPfam hit to PF02151, UvrB/uvrC motif, score 2.5e-10 471473002647 HMMPfam hit to PF07724, ATPase family associated with various cellul, score 4.8e-97 471473002648 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 0.00038 471473002649 PS00017 ATP/GTP-binding site motif A (P-loop) 471473002650 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 471473002651 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 471473002652 Ligand Binding Site [chemical binding]; other site 471473002653 HMMPfam hit to PF03054, tRNA methyl transferase,score 2.9e-224 471473002654 HMMPfam hit to PF01171, PP-loop family, score 0.016 471473002655 HMMPfam hit to PF04156, IncA protein, score 0.00057 471473002656 4 probable transmembrane helices predicted for CTL0540 by TMHMM2.0 at aa 36-58, 63-85, 240-262 and 266-288 471473002657 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 471473002658 2 probable transmembrane helices predicted for CTL0541 by TMHMM2.0 at aa 10-32 and 338-360 471473002659 Helix-turn-helix domain; Region: HTH_17; pfam12728 471473002660 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 471473002661 active site 471473002662 phosphorylation site [posttranslational modification] 471473002663 HMMPfam hit to PF00359,Phosphoenolpyruvate-dependent sugar phosph, score 0.00029 471473002664 PS00372 PTS EIIA domains phosphorylation site signature 2 471473002665 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 471473002666 active site 471473002667 phosphorylation site [posttranslational modification] 471473002668 HMMPfam hit to PF00359,Phosphoenolpyruvate-dependent sugar phosph, score 9.3e-16 471473002669 PS00372 PTS EIIA domains phosphorylation site signature 2 471473002670 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 471473002671 trimer interface [polypeptide binding]; other site 471473002672 active site 471473002673 HMMPfam hit to PF00692, dUTPase, score 8.8e-26 471473002674 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 471473002675 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 471473002676 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 471473002677 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 471473002678 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 471473002679 HMMPfam hit to PF02777, Iron/manganese superoxide dismutases, C-term, score 5.9e-54 471473002680 PS00088 Manganese and iron superoxide dismutases signature 471473002681 HMMPfam hit to PF00081, Iron/manganese superoxide dismutases, alpha-, score 3.8e-46 471473002682 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 471473002683 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 471473002684 active site 471473002685 substrate binding site [chemical binding]; other site 471473002686 metal binding site [ion binding]; metal-binding site 471473002687 HMMPfam hit to PF02880,Phosphoglucomutase/phosphomannomutase, al, score 0.00069 471473002688 HMMPfam hit to PF02879,Phosphoglucomutase/phosphomannomutase, al, score 0.0042 471473002689 HMMPfam hit to PF02878,Phosphoglucomutase/phosphomannomutase, al, score 1.1e-59 471473002690 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature 471473002691 ribonuclease III; Reviewed; Region: rnc; PRK00102 471473002692 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 471473002693 dimerization interface [polypeptide binding]; other site 471473002694 active site 471473002695 metal binding site [ion binding]; metal-binding site 471473002696 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 471473002697 dsRNA binding site [nucleotide binding]; other site 471473002698 HMMPfam hit to PF00636, RNase3 domain, score 4.6e-43 471473002699 PS00517 Ribonuclease III family signature 471473002700 HMMPfam hit to PF00035, Double-stranded RNA binding motif, score 4.2e-15 471473002701 DNA repair protein RadA; Provisional; Region: PRK11823 471473002702 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 471473002703 Walker A motif/ATP binding site; other site 471473002704 ATP binding site [chemical binding]; other site 471473002705 Walker B motif; other site 471473002706 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 471473002707 PS00017 ATP/GTP-binding site motif A (P-loop) 471473002708 porphobilinogen deaminase; Provisional; Region: PRK01066 471473002709 Porphobilinogen deaminase, dipyromethane cofactor binding domain; Region: Porphobil_deam; pfam01379 471473002710 HMMPfam hit to PF01379, Porphobilinogen deaminase,dipyrometha, score 4.1e-17 471473002711 The sequence has been checked and is believed to be correct 471473002712 2 probable transmembrane helices predicted for CTL0552A by TMHMM2.0 at aa 30-52 and 65-87 471473002713 serine/threonine-protein kinase; Reviewed; Region: pknD; PRK13184 471473002714 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471473002715 active site 471473002716 ATP binding site [chemical binding]; other site 471473002717 substrate binding site [chemical binding]; other site 471473002718 activation loop (A-loop); other site 471473002719 HMMPfam hit to PF00069, Protein kinase domain,score 2.3e-44 471473002720 PS00108 Serine/Threonine protein kinases active-site signature 471473002721 PS00107 Protein kinases ATP-binding region signature 471473002722 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 471473002723 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 471473002724 HIGH motif; other site 471473002725 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 471473002726 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 471473002727 active site 471473002728 KMSKS motif; other site 471473002729 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 471473002730 tRNA binding surface [nucleotide binding]; other site 471473002731 anticodon binding site; other site 471473002732 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 471473002733 HMMPfam hit to PF08264, Anticodon-binding domain,score 1.4e-24 471473002734 HMMPfam hit to PF00133, tRNA synthetases class I (I,L, M and V), score 9.5e-213 471473002735 PS00178 Aminoacyl-transfer RNA synthetases class-I signature 471473002736 V-type ATP synthase subunit K; Provisional; Region: PRK09621 471473002737 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 471473002738 4 probable transmembrane helices predicted for CTL0556 by TMHMM2.0 at aa 10-32, 45-67, 77-96 and 117-139 471473002739 HMMPfam hit to PF00137, ATP synthase subunit C,score 0.00038 471473002740 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 471473002741 V-type ATP synthase subunit I; Validated; Region: PRK05771 471473002742 Protein of unknown function (DUF1319); Region: DUF1319; pfam07028 471473002743 HMMPfam hit to PF01496, V-type ATPase 116kDa subunit family, score 1.2e-10 471473002744 7 probable transmembrane helices predicted for CTL0557 by TMHMM2.0 at aa 317-339, 360-382,457-479,486-508, 518-540, 561-583 and 593-615 471473002745 V-type ATP synthase subunit D; Provisional; Region: PRK02195 471473002746 HMMPfam hit to PF01813, ATP synthase subunit D,score 6.2e-79 471473002747 V-type ATP synthase subunit B; Provisional; Region: PRK02118 471473002748 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 471473002749 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 471473002750 Walker A motif homologous position; other site 471473002751 Walker B motif; other site 471473002752 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleot, score 1e-65 471473002753 HMMPfam hit to PF02874, ATP synthase alpha/beta family, beta-ba, score 2.4e-14 471473002754 V-type ATP synthase subunit A; Provisional; Region: PRK04192 471473002755 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 471473002756 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 471473002757 Walker A motif/ATP binding site; other site 471473002758 Walker B motif; other site 471473002759 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 471473002760 HMMPfam hit to PF00306, ATP synthase alpha/beta chain, C termin, score 2.7e-09 471473002761 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleot, score 3.5e-89 471473002762 PS00152 ATP synthase alpha and beta subunits signature 471473002763 PS00017 ATP/GTP-binding site motif A (P-loop) 471473002764 HMMPfam hit to PF02874, ATP synthase alpha/beta family, beta-ba, score 2e-12 471473002765 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 471473002766 PS00017 ATP/GTP-binding site motif A (P-loop) 471473002767 V-type ATP synthase subunit E; Provisional; Region: PRK01005 471473002768 V-type ATP synthase subunit E; Provisional; Region: PRK01558 471473002769 HMMPfam hit to PF01991, ATP synthase (E/31 kDa) subunit, score 0.00014 471473002770 PS00652 TNFR/NGFR family cysteine-rich region signature 471473002771 transaldolase-like protein; Provisional; Region: PTZ00411 471473002772 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 471473002773 active site 471473002774 dimer interface [polypeptide binding]; other site 471473002775 catalytic residue [active] 471473002776 HMMPfam hit to PF00923, Transaldolase, score 7.8e-121 471473002777 PS00958 Transaldolase active site 471473002778 PS01054 Transaldolase signature 1 471473002779 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 471473002780 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 471473002781 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 471473002782 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 471473002783 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 471473002784 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 471473002785 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 471473002786 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 471473002787 DNA binding site [nucleotide binding] 471473002788 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 471473002789 HMMPfam hit to PF04998, RNA polymerase Rpb1,domain,score 1.2e-122 471473002790 HMMPfam hit to PF05000, RNA polymerase Rpb1,domain,score 6.9e-25 471473002791 HMMPfam hit to PF04983, RNA polymerase Rpb1,domain,score 1.5e-39 471473002792 HMMPfam hit to PF00623, RNA polymerase Rpb1,domain,score 2.4e-86 471473002793 HMMPfam hit to PF04997, RNA polymerase Rpb1,domain,score 1.4e-165 471473002794 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 471473002795 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 471473002796 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 471473002797 DNA-directed RNA polymerase, beta subunit; Region: rpoB; TIGR02013 471473002798 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 471473002799 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 471473002800 RPB12 interaction site [polypeptide binding]; other site 471473002801 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 471473002802 RPB3 interaction site [polypeptide binding]; other site 471473002803 RPB1 interaction site [polypeptide binding]; other site 471473002804 RPB11 interaction site [polypeptide binding]; other site 471473002805 RPB10 interaction site [polypeptide binding]; other site 471473002806 HMMPfam hit to PF04560, RNA polymerase Rpb2,domain,score 6.4e-46 471473002807 HMMPfam hit to PF00562, RNA polymerase Rpb2,domain,score 2.1e-181 471473002808 PS00017 ATP/GTP-binding site motif A (P-loop) 471473002809 PS01166 RNA polymerases beta chain signature 471473002810 HMMPfam hit to PF04565, RNA polymerase Rpb2,domain,score 5.9e-43 471473002811 HMMPfam hit to PF04563, RNA polymerase beta subunit,score 8.6e-30 471473002812 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 471473002813 L11 interface [polypeptide binding]; other site 471473002814 putative EF-Tu interaction site [polypeptide binding]; other site 471473002815 putative EF-G interaction site [polypeptide binding]; other site 471473002816 HMMPfam hit to PF00542, Ribosomal protein L7/L12 C-terminal dom, score 4e-39 471473002817 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 471473002818 23S rRNA interface [nucleotide binding]; other site 471473002819 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 471473002820 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 471473002821 mRNA/rRNA interface [nucleotide binding]; other site 471473002822 HMMPfam hit to PF00687, Ribosomal protein L1p/L10e family, score 2.7e-108 471473002823 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 471473002824 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 471473002825 putative thiostrepton binding site; other site 471473002826 23S rRNA interface [nucleotide binding]; other site 471473002827 L7/L12 interface [polypeptide binding]; other site 471473002828 L25 interface [polypeptide binding]; other site 471473002829 PS00359 Ribosomal protein L11 signature 471473002830 HMMPfam hit to PF00298, Ribosomal protein L11, RNA binding do, score 5.9e-31 471473002831 HMMPfam hit to PF03946, Ribosomal protein L11,N-terminal dom, score 5.3e-31 471473002832 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 471473002833 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 471473002834 putative homodimer interface [polypeptide binding]; other site 471473002835 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 471473002836 heterodimer interface [polypeptide binding]; other site 471473002837 homodimer interface [polypeptide binding]; other site 471473002838 HMMPfam hit to PF00467, KOW motif, score 5.2e-08 471473002839 HMMPfam hit to PF02357, Transcription termination factor nusG, score 2.8e-37 471473002840 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 471473002841 1 probable transmembrane helix predicted for CTL0573 by TMHMM2.0 at aa 47-66 471473002842 elongation factor Tu; Reviewed; Region: PRK12735 471473002843 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 471473002844 G1 box; other site 471473002845 GEF interaction site [polypeptide binding]; other site 471473002846 GTP/Mg2+ binding site [chemical binding]; other site 471473002847 Switch I region; other site 471473002848 G2 box; other site 471473002849 G3 box; other site 471473002850 Switch II region; other site 471473002851 G4 box; other site 471473002852 G5 box; other site 471473002853 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 471473002854 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 471473002855 Antibiotic Binding Site [chemical binding]; other site 471473002856 HMMPfam hit to PF03143, Elongation factor Tu C-terminal domain, score 2e-57 471473002857 HMMPfam hit to PF03144, Elongation factor Tu domain,score 2.7e-25 471473002858 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 4.7e-96 471473002859 PS00301 GTP-binding elongation factors signature 471473002860 PS00017 ATP/GTP-binding site motif A (P-loop) 471473002861 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 471473002862 rRNA binding site [nucleotide binding]; other site 471473002863 predicted 30S ribosome binding site; other site 471473002864 HMMPfam hit to PF00575, S1 RNA binding domain,score 1.2e-05 471473002865 HMMPfam hit to PF01176, Translation initiation factor 1A / IF-1, score 3.6e-26 471473002866 3 probable transmembrane helices predicted for CTL0576 by TMHMM2.0 at aa 76-93, 97-119 and 150-172 471473002867 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 471473002868 HMMPfam hit to PF02657, Fe-S metabolism associated domain, score 1.2e-67 471473002869 The sequence has been checked and is believed to be correct 471473002870 HMMPfam hit to PF05095, Protein of unknown function (DUF687), score 0 471473002871 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 471473002872 active site 471473002873 HMMPfam hit to PF00697,N-(5'phosphoribosyl)anthranilate (PRA) isome, score 2.6e-26 471473002874 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 471473002875 triosephosphate isomerase; Provisional; Region: PRK14565 471473002876 substrate binding site [chemical binding]; other site 471473002877 dimer interface [polypeptide binding]; other site 471473002878 catalytic triad [active] 471473002879 HMMPfam hit to PF00121, Triosephosphate isomerase,score 3e-141 471473002880 PS00171 Triosephosphate isomerase active site 471473002881 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 471473002882 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 471473002883 generic binding surface II; other site 471473002884 generic binding surface I; other site 471473002885 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 8.3e-08 471473002886 HMMPfam hit to PF02601, Exonuclease VII, large subunit, score 3.7e-152 471473002887 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 471473002888 HMMPfam hit to PF02609, Exonuclease VII small subunit, score 3.1e-08 471473002889 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 471473002890 1-deoxy-D-xylulose-5-phosphate synthase; Region: DXP_synthase_N; pfam13292 471473002891 TPP-binding site [chemical binding]; other site 471473002892 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 471473002893 PYR/PP interface [polypeptide binding]; other site 471473002894 dimer interface [polypeptide binding]; other site 471473002895 TPP binding site [chemical binding]; other site 471473002896 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471473002897 PS00801 Transketolase signature 1 471473002898 HMMPfam hit to PF02779, Transketolase, pyridine binding domai, score 3.8e-50 471473002899 HMMPfam hit to PF02780, Transketolase, C-terminal domain, score 5.6e-44 471473002900 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 471473002901 pyruvate kinase; Region: pyruv_kin; TIGR01064 471473002902 domain interfaces; other site 471473002903 active site 471473002904 HMMPfam hit to PF00224, Pyruvate kinase, barrel domain, score 1.1e-137 471473002905 HMMPfam hit to PF02887, Pyruvate kinase, alpha/beta domain, score 5.9e-13 471473002906 excinuclease ABC subunit A; Provisional; Region: PRK00635 471473002907 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 471473002908 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 471473002909 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 471473002910 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471473002911 Walker A/P-loop; other site 471473002912 ATP binding site [chemical binding]; other site 471473002913 Q-loop/lid; other site 471473002914 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471473002915 ABC transporter signature motif; other site 471473002916 Walker B; other site 471473002917 D-loop; other site 471473002918 H-loop/switch region; other site 471473002919 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471473002920 Walker A/P-loop; other site 471473002921 ATP binding site [chemical binding]; other site 471473002922 Q-loop/lid; other site 471473002923 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471473002924 Q-loop/lid; other site 471473002925 ABC transporter signature motif; other site 471473002926 Walker B; other site 471473002927 D-loop; other site 471473002928 H-loop/switch region; other site 471473002929 HMMPfam hit to PF00005, ABC transporter, score 1.1e-08 471473002930 PS00017 ATP/GTP-binding site motif A (P-loop) 471473002931 PS00017 ATP/GTP-binding site motif A (P-loop) 471473002932 HMMPfam hit to PF00005, ABC transporter, score 7.8e-13 471473002933 PS00017 ATP/GTP-binding site motif A (P-loop) 471473002934 PS00017 ATP/GTP-binding site motif A (P-loop) 471473002935 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06305 471473002936 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471473002937 Walker A motif; other site 471473002938 ATP binding site [chemical binding]; other site 471473002939 Walker B motif; other site 471473002940 arginine finger; other site 471473002941 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 5.5e-07 471473002942 PS00017 ATP/GTP-binding site motif A (P-loop) 471473002943 hypothetical protein; Validated; Region: PRK00153 471473002944 HMMPfam hit to PF02575, Uncharacterised BCR, YbaB family COG0718, score 1.6e-38 471473002945 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 471473002946 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 471473002947 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 471473002948 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 471473002949 HMMPfam hit to PF02896, PEP-utilising enzyme, TIM barrel doma, score 7.9e-37 471473002950 HMMPfam hit to PF00391, PEP-utilising enzyme,mobile domain, score 2.5e-20 471473002951 HMMPfam hit to PF05524, PEP-utilising enzyme,N-terminal, score 1.3e-13 471473002952 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 471473002953 dimerization domain swap beta strand [polypeptide binding]; other site 471473002954 regulatory protein interface [polypeptide binding]; other site 471473002955 active site 471473002956 regulatory phosphorylation site [posttranslational modification]; other site 471473002957 HMMPfam hit to PF00381, PTS HPr component phosphorylation site, score 1.2e-16 471473002958 PS00589 PTS HPR component serine phosphorylation site signature 471473002959 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 471473002960 Competence protein; Region: Competence; pfam03772 471473002961 9 probable transmembrane helices predicted for CTL0593 by TMHMM2.0 at aa 42-64, 76-93, 254-276,283-302,317-339, 346-368, 381-403, 416-438 and 474-496 471473002962 HMMPfam hit to PF03772, Competence protein, score 4.5e-59 471473002963 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 471473002964 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 471473002965 tetramer interface [polypeptide binding]; other site 471473002966 TPP-binding site [chemical binding]; other site 471473002967 heterodimer interface [polypeptide binding]; other site 471473002968 phosphorylation loop region [posttranslational modification] 471473002969 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 471473002970 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 471473002971 alpha subunit interface [polypeptide binding]; other site 471473002972 TPP binding site [chemical binding]; other site 471473002973 heterodimer interface [polypeptide binding]; other site 471473002974 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471473002975 HMMPfam hit to PF02780, Transketolase, C-terminal domain, score 2.8e-56 471473002976 HMMPfam hit to PF02779, Transketolase, pyridine binding domai, score 8e-74 471473002977 HMMPfam hit to PF00676, Dehydrogenase E1 component,score 1.4e-29 471473002978 PS00017 ATP/GTP-binding site motif A (P-loop) 471473002979 chaperone protein DnaJ; Provisional; Region: PRK14284 471473002980 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 471473002981 HSP70 interaction site [polypeptide binding]; other site 471473002982 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 471473002983 Zn binding sites [ion binding]; other site 471473002984 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 471473002985 dimer interface [polypeptide binding]; other site 471473002986 HMMPfam hit to PF01556, DnaJ C terminal region,score 9.6e-54 471473002987 HMMPfam hit to PF00684, DnaJ central domain (4 repeats), score 1.6e-23 471473002988 HMMPfam hit to PF00226, DnaJ domain, score 4.6e-40 471473002989 PS00636 Nt-dnaJ domain signature 471473002990 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 471473002991 HMMPfam hit to PF01165, Ribosomal protein S21,score 9e-11 471473002992 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 471473002993 Glycoprotease family; Region: Peptidase_M22; pfam00814 471473002994 HMMPfam hit to PF00814, Glycoprotease family, score 3.4e-05 471473002995 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 471473002996 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471473002997 Walker A motif; other site 471473002998 ATP binding site [chemical binding]; other site 471473002999 Walker B motif; other site 471473003000 arginine finger; other site 471473003001 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 471473003002 HMMPfam hit to PF02190, ATP-dependent protease La (LON) domain, score 1.6e-16 471473003003 HMMPfam hit to PF00004, ATPase family associated with various cellul, score 2.2e-48 471473003004 HMMPfam hit to PF07728, ATPase family associated with various cellul, score 3.2e-05 471473003005 PS00017 ATP/GTP-binding site motif A (P-loop) 471473003006 HMMPfam hit to PF05362, Lon protease (S16) C-terminal proteolytic do, score 1.3e-107 471473003007 PS01046 ATP-dependent serine proteases, lon family,serine active site 471473003008 2 probable transmembrane helices predicted for CTL0599 by TMHMM2.0 at aa 31-53 and 57-79 471473003009 ribonuclease Z; Region: RNase_Z; TIGR02651 471473003010 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 3.5e-10 471473003011 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 471473003012 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 471473003013 active site 471473003014 Int/Topo IB signature motif; other site 471473003015 HMMPfam hit to PF02899, Phage integrase, N-terminal SAM-like, score 8.7e-05 471473003016 HMMPfam hit to PF00589, Phage integrase family,score 1.9e-44 471473003017 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471473003018 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471473003019 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471473003020 ABC transporter; Region: ABC_tran_2; pfam12848 471473003021 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471473003022 HMMPfam hit to PF00005, ABC transporter, score 1.2e-32 471473003023 PS00017 ATP/GTP-binding site motif A (P-loop) 471473003024 HMMPfam hit to PF00005, ABC transporter, score 9.9e-37 471473003025 PS00017 ATP/GTP-binding site motif A (P-loop) 471473003026 Maf-like protein; Region: Maf; pfam02545 471473003027 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 471473003028 active site 471473003029 dimer interface [polypeptide binding]; other site 471473003030 HMMPfam hit to PF02545, Maf-like protein, score 1.4e-107 471473003031 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 471473003032 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 471473003033 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 471473003034 2 probable transmembrane helices predicted for CTL0606 by TMHMM2.0 at aa 3-25 and 57-79 471473003035 HMMPfam hit to PF03840, Preprotein translocase SecG subunit, score 6.9e-24 471473003036 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 471473003037 active site 471473003038 catalytic residues [active] 471473003039 metal binding site [ion binding]; metal-binding site 471473003040 HMMPfam hit to PF01327, Polypeptide deformylase,score 6.2e-51 471473003041 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 471473003042 dimethyladenosine transferase; Region: ksgA; TIGR00755 471473003043 HMMPfam hit to PF00398, Ribosomal RNA adenine dimethylase, score 5.6e-56 471473003044 PS01131 Ribosomal RNA adenine dimethylases signature 471473003045 1 probable transmembrane helix predicted for CTL0609 by TMHMM2.0 at aa 7-29 471473003046 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 471473003047 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 471473003048 catalytic residues [active] 471473003049 PS00336 Beta-lactamase class-C active site 471473003050 HMMPfam hit to PF03190, Protein of unknown function,DUF255, score 7.6e-48 471473003051 2 probable transmembrane helices predicted for CTL0611A by TMHMM2.0 at aa 37-59 and 64-86 471473003052 The sequence has been checked and is believed to be correct 471473003053 2 probable transmembrane helices predicted for CTL0612 by TMHMM2.0 at aa 45-67 and 77-99 471473003054 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 471473003055 HMMPfam hit to PF02632, BioY family, score 1.5e-70 471473003056 5 probable transmembrane helices predicted for CTL0613 by TMHMM2.0 at aa 22-44, 51-73, 88-113, 125-147 and 162-184 471473003057 PS00011 Vitamin K-dependent carboxylation domain 471473003058 dihydrodipicolinate synthase; Region: dapA; TIGR00674 471473003059 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 471473003060 inhibitor site; inhibition site 471473003061 active site 471473003062 dimer interface [polypeptide binding]; other site 471473003063 catalytic residue [active] 471473003064 HMMPfam hit to PF00701, Dihydrodipicolinate synthetase family, score 2.2e-15 471473003065 PS00665 Dihydrodipicolinate synthetase signature 1 471473003066 aspartate kinase; Provisional; Region: PRK05925 471473003067 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 471473003068 putative catalytic residues [active] 471473003069 nucleotide binding site [chemical binding]; other site 471473003070 aspartate binding site [chemical binding]; other site 471473003071 HMMPfam hit to PF00696, Amino acid kinase family,score 1.8e-54 471473003072 PS00017 ATP/GTP-binding site motif A (P-loop) 471473003073 PS00324 Aspartokinase signature 471473003074 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 471473003075 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 471473003076 HMMPfam hit to PF02774, Semialdehyde dehydrogenase,dimerisat, score 7.1e-20 471473003077 HMMPfam hit to PF01118, Semialdehyde dehydrogenase,NAD bindi, score 7.8e-36 471473003078 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 471473003079 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 471473003080 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 471473003081 HMMPfam hit to PF05173, Dihydrodipicolinate reductase, C-terminus, score 1.8e-57 471473003082 HMMPfam hit to PF01113, Dihydrodipicolinate reductase, N-terminus, score 1.1e-29 471473003083 10 probable transmembrane helices predicted for CTL0619 by TMHMM2.0 at aa 55-77, 83-105, 125-147,162-179,212-234, 238-260, 338-360, 370-392, 469-491 and 495-517 471473003084 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 471473003085 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 471473003086 hinge; other site 471473003087 active site 471473003088 HMMPfam hit to PF00275, EPSP synthase (3-phosphoshikimate 1-car, score 1.2e-75 471473003089 PS00885 EPSP synthase signature 2 471473003090 shikimate kinase; Provisional; Region: PRK00625 471473003091 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 471473003092 ADP binding site [chemical binding]; other site 471473003093 magnesium binding site [ion binding]; other site 471473003094 putative shikimate binding site; other site 471473003095 PS00017 ATP/GTP-binding site motif A (P-loop) 471473003096 HMMPfam hit to PF01202, Shikimate kinase, score 2.3e-32 471473003097 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 471473003098 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 471473003099 Tetramer interface [polypeptide binding]; other site 471473003100 active site 471473003101 FMN-binding site [chemical binding]; other site 471473003102 HMMPfam hit to PF01264, Chorismate synthase, score 3e-126 471473003103 PS00787 Chorismate synthase signature 1 471473003104 PS00788 Chorismate synthase signature 2 471473003105 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 471473003106 dimer interface [polypeptide binding]; other site 471473003107 active site 471473003108 metal binding site [ion binding]; metal-binding site 471473003109 HMMPfam hit to PF01761, 3-dehydroquinate synthase,score 1.5e-124 471473003110 bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase protein; Reviewed; Region: aroDE; PRK09310 471473003111 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 471473003112 active site 471473003113 catalytic residue [active] 471473003114 dimer interface [polypeptide binding]; other site 471473003115 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 471473003116 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 471473003117 shikimate binding site; other site 471473003118 NAD(P) binding site [chemical binding]; other site 471473003119 HMMPfam hit to PF01487, Type I 3-dehydroquinase,score 6.7e-77 471473003120 HMMPfam hit to PF08501, Shikimate dehydrogenase substrate bind, score 2.1e-16 471473003121 HMMPfam hit to PF01488, Shikimate / quinate 5-dehydrogenase, score 7.2e-08 471473003122 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 471473003123 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 471473003124 HMMPfam hit to PF04966, Carbohydrate-selective porin, OprB family, score 2e-31 471473003125 The sequence has been checked and is believed to be correct 471473003126 HMMPfam hit to PF01862, Pyruvoyl-dependent arginine decarboxylase (P, score 1.7e-84 471473003127 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 471473003128 13 probable transmembrane helices predicted for CTL0628 by TMHMM2.0 at aa 11-33, 48-70, 90-112,127-149,156-178, 209-228, 241-263, 293-315, 335-357,367-389,402-419, 423-445 and 458-477 471473003129 HMMPfam hit to PF00324, Amino acid permease, score 3.2e-07 471473003130 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature 471473003131 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 471473003132 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471473003133 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 6.1e-54 471473003134 malate dehydrogenase; Provisional; Region: PRK05442 471473003135 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 471473003136 NAD(P) binding site [chemical binding]; other site 471473003137 dimer interface [polypeptide binding]; other site 471473003138 malate binding site [chemical binding]; other site 471473003139 HMMPfam hit to PF02866, lactate/malate dehydrogenase, alpha/beta C-t, score 1.3e-28 471473003140 HMMPfam hit to PF00056, lactate/malate dehydrogenase, NAD binding do, score 3e-36 471473003141 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 471473003142 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 471473003143 active site 471473003144 dimer interface [polypeptide binding]; other site 471473003145 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 471473003146 dimer interface [polypeptide binding]; other site 471473003147 active site 471473003148 HMMPfam hit to PF00342, Phosphoglucose isomerase,score 1.6e-116 471473003149 PS00017 ATP/GTP-binding site motif A (P-loop) 471473003150 GTPases [General function prediction only]; Region: HflX; COG2262 471473003151 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 471473003152 HflX GTPase family; Region: HflX; cd01878 471473003153 G1 box; other site 471473003154 GTP/Mg2+ binding site [chemical binding]; other site 471473003155 Switch I region; other site 471473003156 G2 box; other site 471473003157 G3 box; other site 471473003158 Switch II region; other site 471473003159 G4 box; other site 471473003160 G5 box; other site 471473003161 HMMPfam hit to PF01926, GTPase of unknown function,score 1.2e-37 471473003162 PS00017 ATP/GTP-binding site motif A (P-loop) 471473003163 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 471473003164 putative hydrolase; Provisional; Region: PRK02113 471473003165 HMMPfam hit to PF00753, Metallo-beta-lactamase superfamily, score 7.9e-15 471473003166 PS00022 EGF-like domain signature 1 471473003167 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 471473003168 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 471473003169 substrate binding pocket [chemical binding]; other site 471473003170 membrane-bound complex binding site; other site 471473003171 hinge residues; other site 471473003172 HMMPfam hit to PF00497, Bacterial extracellular solute-binding prot, score 1e-32 471473003173 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 471473003174 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 471473003175 HMMPfam hit to PF00793, DAHP synthetase I family,score 3.1e-121 471473003176 IncA protein; Region: IncA; pfam04156 471473003177 2 probable transmembrane helices predicted for CTL0639 by TMHMM2.0 at aa 106-128 and 133-155 471473003178 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 471473003179 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 471473003180 nucleotide binding site/active site [active] 471473003181 HMMPfam hit to PF01230, HIT domain, score 7.9e-35 471473003182 PS00892 HIT family signature 471473003183 Uncharacterized conserved protein related to MYG1 family [Function unknown]; Region: COG4286 471473003184 HMMPfam hit to PF03690, Uncharacterised protein family (UPF0160), score 1.1e-180 471473003185 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 471473003186 hypothetical protein; Validated; Region: PRK00647 471473003187 HMMPfam hit to PF02594, Uncharacterised ACR, YggU family COG1872, score 1.6e-32 471473003188 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 471473003189 1 probable transmembrane helix predicted for CTL0645 by TMHMM2.0 at aa 7-24 471473003190 HMMPfam hit to PF06727, Protein of unknown function (DUF1207), score 6.7e-295 471473003191 LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542 471473003192 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471473003193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471473003194 homodimer interface [polypeptide binding]; other site 471473003195 catalytic residue [active] 471473003196 HMMPfam hit to PF00155, Aminotransferase class I and II, score 1.5e-32 471473003197 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site 471473003198 ABC transporter substrate binding protein; Region: ABC_sub_bind; pfam04392 471473003199 1 probable transmembrane helix predicted for CTL0647 by TMHMM2.0 at aa 7-29 471473003200 HMMPfam hit to PF04392, ABC transporter substrate binding protei, score 3.6e-132 471473003201 prolyl-tRNA synthetase; Provisional; Region: PRK09194 471473003202 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 471473003203 dimer interface [polypeptide binding]; other site 471473003204 motif 1; other site 471473003205 active site 471473003206 motif 2; other site 471473003207 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 471473003208 putative deacylase active site [active] 471473003209 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 471473003210 active site 471473003211 motif 3; other site 471473003212 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 471473003213 anticodon binding site; other site 471473003214 HMMPfam hit to PF00587, tRNA synthetase class II core domain (, score 1e-51 471473003215 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1 471473003216 PS00017 ATP/GTP-binding site motif A (P-loop) 471473003217 HMMPfam hit to PF04073, YbaK / prolyl-tRNA synthetases associa, score 7.6e-05 471473003218 HMMPfam hit to PF03129, Anticodon binding domain,score 2.9e-20 471473003219 Transcriptional regulator of heat shock gene [Transcription]; Region: HrcA; COG1420 471473003220 HMMPfam hit to PF01628, HrcA protein C terminal domain, score 3.3e-76 471473003221 GrpE; Region: GrpE; pfam01025 471473003222 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 471473003223 dimer interface [polypeptide binding]; other site 471473003224 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 471473003225 HMMPfam hit to PF01025, GrpE, score 5.3e-72 471473003226 PS01071 grpE protein signature 471473003227 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 471473003228 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 471473003229 nucleotide binding site [chemical binding]; other site 471473003230 NEF interaction site [polypeptide binding]; other site 471473003231 SBD interface [polypeptide binding]; other site 471473003232 Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811 471473003233 PS00297 Heat shock hsp70 proteins family signature 1 471473003234 PS00329 Heat shock hsp70 proteins family signature 2 471473003235 PS01036 Heat shock hsp70 proteins family signature 3 471473003236 Exoribonuclease R [Transcription]; Region: VacB; COG0557 471473003237 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 471473003238 RNB domain; Region: RNB; pfam00773 471473003239 HMMPfam hit to PF00773, RNB-like protein, score 2.1e-123 471473003240 PS01175 Ribonuclease II family signature 471473003241 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 471473003242 Putative zinc ribbon domain; Region: DUF164; pfam02591 471473003243 HMMPfam hit to PF02591, Uncharacterized ACR,COG1579,score 2.2e-129 471473003244 KpsF/GutQ family protein; Region: kpsF; TIGR00393 471473003245 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 471473003246 putative active site [active] 471473003247 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 471473003248 HMMPfam hit to PF00571, CBS domain pair, score 3.6e-16 471473003249 HMMPfam hit to PF01380, SIS domain, score 1.2e-19 471473003250 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 471473003251 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471473003252 E3 interaction surface; other site 471473003253 lipoyl attachment site [posttranslational modification]; other site 471473003254 e3 binding domain; Region: E3_binding; pfam02817 471473003255 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 471473003256 HMMPfam hit to PF00198, 2-oxoacid dehydrogenases acyltransferas, score 2.6e-110 471473003257 HMMPfam hit to PF02817, e3 binding domain, score 1.5e-13 471473003258 HMMPfam hit to PF00364, Biotin-requiring enzyme,score 3.1e-18 471473003259 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site 471473003260 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 471473003261 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 471473003262 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter family, score 8.5e-107 471473003263 8 probable transmembrane helices predicted for CTL0658 by TMHMM2.0 at aa 7-21, 36-58, 71-93,136-158,179-198, 213-235, 312-334 and 344-366 471473003264 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 471473003265 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 471473003266 HMMPfam hit to PF02606, Tetraacyldisaccharide-1-P 4'-kinase, score 4.3e-222 471473003267 PS00136 Serine proteases, subtilase family,aspartic acid active site 471473003268 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 471473003269 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 471473003270 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 471473003271 HMMPfam hit to PF00588, SpoU rRNA Methylase family,score 6.1e-45 471473003272 HMMPfam hit to PF08032, RNA 2'-O ribose methyltransferase subs, score 7.7e-13 471473003273 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 471473003274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471473003275 S-adenosylmethionine binding site [chemical binding]; other site 471473003276 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 471473003277 Lumazine binding domain; Region: Lum_binding; pfam00677 471473003278 Lumazine binding domain; Region: Lum_binding; pfam00677 471473003279 HMMPfam hit to PF00677, Lumazine binding domain,score 5.4e-26 471473003280 HMMPfam hit to PF00677, Lumazine binding domain,score 2.7e-13 471473003281 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327 471473003282 ATP cone domain; Region: ATP-cone; pfam03477 471473003283 HMMPfam hit to PF03477, ATP cone domain, score 1.1e-29 471473003284 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 471473003285 HMMPfam hit to PF01258, Prokaryotic dksA/traR C4-type zinc finge, score 1.7e-07 471473003286 Lipoprotein signal peptidase [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: LspA; COG0597 471473003287 5 probable transmembrane helices predicted for CTL0665 by TMHMM2.0 at aa 5-27, 40-62, 66-88, 101-123 and 138-160 471473003288 HMMPfam hit to PF01252, Signal peptidase (SPase) II,score 5.5e-16 471473003289 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 471473003290 amino acid carrier protein; Region: agcS; TIGR00835 471473003291 11 probable transmembrane helices predicted for CTL0666 by TMHMM2.0 at aa 15-32, 70-92, 102-124,151-173,186-203, 210-232, 242-264, 303-325, 350-372,385-402 and 407-429 471473003292 HMMPfam hit to PF01235, Sodium:alanine symporter family, score 1.2e-16 471473003293 poly(A) polymerase; Region: pcnB; TIGR01942 471473003294 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 471473003295 active site 471473003296 NTP binding site [chemical binding]; other site 471473003297 metal binding triad [ion binding]; metal-binding site 471473003298 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 471473003299 HMMPfam hit to PF01743, Poly A polymerase family,score 7.9e-72 471473003300 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK01021 471473003301 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578 471473003302 Predicted membrane protein [Function unknown]; Region: COG3952 471473003303 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 471473003304 6 probable transmembrane helices predicted for CTL0668 by TMHMM2.0 at aa 10-32, 39-61, 65-82,95-117,137-156 and 168-190 471473003305 HMMPfam hit to PF07578, Lipid A Biosynthesis N-terminal domain, score 9.7e-38 471473003306 HMMPfam hit to PF07578, Lipid A Biosynthesis N-terminal domain, score 6.6e-39 471473003307 HMMPfam hit to PF02684, Lipid-A-disaccharide synthetase, score 2e-227 471473003308 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 471473003309 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 471473003310 Autotransporter beta-domain; Region: Autotransporter; pfam03797 471473003311 1 probable transmembrane helix predicted for CTL0669 by TMHMM2.0 at aa 24-46 471473003312 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 3.5 471473003313 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.01 471473003314 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.0052 471473003315 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.26 471473003316 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.0052 471473003317 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.11 471473003318 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.13 471473003319 HMMPfam hit to PF07548, Chlamydia polymorphic membrane protei, score 1.4e-55 471473003320 HMMPfam hit to PF03797, Autotransporter beta-domain,score 1.2e-40 471473003321 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 471473003322 Autotransporter beta-domain; Region: Autotransporter; pfam03797 471473003323 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.3 471473003324 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.34 471473003325 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 2.2 471473003326 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 1.4 471473003327 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.066 471473003328 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 2.1 471473003329 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 44 471473003330 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 9.5 471473003331 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.39 471473003332 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 4.5 471473003333 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.42 471473003334 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 8 471473003335 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.021 471473003336 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.98 471473003337 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 4.6 471473003338 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.65 471473003339 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.034 471473003340 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 12 471473003341 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 4.1 471473003342 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 44 471473003343 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 13 471473003344 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 2 471473003345 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.74 471473003346 HMMPfam hit to PF07548, Chlamydia polymorphic membrane protei, score 1.7e-54 471473003347 HMMPfam hit to PF03797, Autotransporter beta-domain,score 4.3e-40 471473003348 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 471473003349 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 471473003350 Autotransporter beta-domain; Region: Autotransporter; pfam03797 471473003351 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 42 471473003352 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 9.7 471473003353 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.33 471473003354 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 46 471473003355 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.95 471473003356 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 10 471473003357 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.041 471473003358 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.04 471473003359 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.039 471473003360 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 2 471473003361 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 36 471473003362 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.31 471473003363 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.19 471473003364 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.62 471473003365 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 9.5 471473003366 HMMPfam hit to PF02415, Chlamydia polymorphic membrane protei, score 0.35 471473003367 HMMPfam hit to PF07548, Chlamydia polymorphic membrane protei, score 1.5e-51 471473003368 HMMPfam hit to PF03797, Autotransporter beta-domain,score 9e-40 471473003369 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 471473003370 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 471473003371 intersubunit interface [polypeptide binding]; other site 471473003372 HMMPfam hit to PF01297, Periplasmic solute binding protein family, score 8.4e-116 471473003373 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 471473003374 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471473003375 HMMPfam hit to PF00005, ABC transporter, score 8.4e-42 471473003376 PS00017 ATP/GTP-binding site motif A (P-loop) 471473003377 PS00211 ABC transporters family signature 471473003378 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471473003379 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 471473003380 ABC-ATPase subunit interface; other site 471473003381 dimer interface [polypeptide binding]; other site 471473003382 putative PBP binding regions; other site 471473003383 HMMPfam hit to PF00950, ABC 3 transport family,score 1.1e-57 471473003384 8 probable transmembrane helices predicted for CTL0674 by TMHMM2.0 at aa 15-37, 44-66, 70-92,101-123,143-165, 186-208, 228-250 and 255-277 471473003385 GTPase CgtA; Reviewed; Region: obgE; PRK12299 471473003386 GTP1/OBG; Region: GTP1_OBG; pfam01018 471473003387 Obg GTPase; Region: Obg; cd01898 471473003388 G1 box; other site 471473003389 GTP/Mg2+ binding site [chemical binding]; other site 471473003390 Switch I region; other site 471473003391 G2 box; other site 471473003392 G3 box; other site 471473003393 Switch II region; other site 471473003394 G4 box; other site 471473003395 G5 box; other site 471473003396 HMMPfam hit to PF01926, GTPase of unknown function,score 1.8e-39 471473003397 PS00017 ATP/GTP-binding site motif A (P-loop) 471473003398 HMMPfam hit to PF01018, GTP1/OBG, score 1.4e-66 471473003399 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 471473003400 HMMPfam hit to PF01016, Ribosomal L27 protein,score 1.4e-40 471473003401 Ribosomal protein L21 [Translation, ribosomal structure and biogenesis]; Region: RplU; COG0261 471473003402 HMMPfam hit to PF00829, Ribosomal prokaryotic L21 protein, score 1.3e-43 471473003403 Uncharacterized conserved protein [Function unknown]; Region: COG2928 471473003404 2 probable transmembrane helices predicted for CTL0678 by TMHMM2.0 at aa 23-45 and 78-100 471473003405 HMMPfam hit to PF04367, Protein of unknown function (DUF502), score 4.3e-89 471473003406 Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137 471473003407 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 471473003408 HMMPfam hit to PF02130, Uncharacterized protein family UPF0054, score 0.0012 471473003409 FOG: CBS domain [General function prediction only]; Region: COG0517 471473003410 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471473003411 Transporter associated domain; Region: CorC_HlyC; smart01091 471473003412 3 probable transmembrane helices predicted for CTL0682 by TMHMM2.0 at aa 2-19, 42-64 and 71-93 471473003413 HMMPfam hit to PF00571, CBS domain pair, score 6.7e-20 471473003414 HMMPfam hit to PF03471, Transporter associated domain, score 7.8e-22 471473003415 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471473003416 anti sigma factor interaction site; other site 471473003417 regulatory phosphorylation site [posttranslational modification]; other site 471473003418 HMMPfam hit to PF01740, STAS domain, score 6e-30 471473003419 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 471473003420 hypothetical protein; Provisional; Region: PRK05926 471473003421 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471473003422 FeS/SAM binding site; other site 471473003423 HMMPfam hit to PF04055, Radical SAM superfamily,score 3.3e-16 471473003424 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 471473003425 HMMPfam hit to PF02621, Uncharacterized ACR,COG1427,score 4.8e-161 471473003426 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 471473003427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471473003428 S-adenosylmethionine binding site [chemical binding]; other site 471473003429 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 471473003430 HMMPfam hit to PF01209, ubiE/COQ5 methyltransferase family, score 2.3e-15 471473003431 HMMPfam hit to PF08241, Methyltransferase domain,score 1.1e-22 471473003432 HMMPfam hit to PF08242, Methyltransferase domain,score 1.7e-09 471473003433 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 471473003434 HMMPfam hit to PF03682, Uncharacterised protein family (UPF0158), score 9e-120 471473003435 diaminopimelate epimerase; Region: DapF; TIGR00652 471473003436 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 471473003437 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 471473003438 HMMPfam hit to PF01678, Diaminopimelate epimerase,score 1.5e-09 471473003439 HMMPfam hit to PF01678, Diaminopimelate epimerase,score 2.5e-05 471473003440 PS01326 Diaminopimelate epimerase signature 471473003441 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 471473003442 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 471473003443 oligomer interface [polypeptide binding]; other site 471473003444 active site residues [active] 471473003445 HMMPfam hit to PF00574, Clp protease, score 1.2e-89 471473003446 PS00382 Endopeptidase Clp histidine active site 471473003447 serine hydroxymethyltransferase; Provisional; Region: PRK13580 471473003448 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 471473003449 dimer interface [polypeptide binding]; other site 471473003450 active site 471473003451 glycine-pyridoxal phosphate binding site [chemical binding]; other site 471473003452 folate binding site [chemical binding]; other site 471473003453 HMMPfam hit to PF00464, Serine hydroxymethyltransferase, score 2.9e-138 471473003454 PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site 471473003455 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 471473003456 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 471473003457 active site 471473003458 HMMPfam hit to PF02602, Uroporphyrinogen-III synthase HemD, score 2.5e-61 471473003459 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 471473003460 homotrimer interaction site [polypeptide binding]; other site 471473003461 zinc binding site [ion binding]; other site 471473003462 CDP-binding sites; other site 471473003463 HMMPfam hit to PF02542, YgbB family, score 2.6e-89 471473003464 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 471473003465 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 471473003466 FAD binding pocket [chemical binding]; other site 471473003467 conserved FAD binding motif [chemical binding]; other site 471473003468 phosphate binding motif [ion binding]; other site 471473003469 beta-alpha-beta structure motif; other site 471473003470 NAD binding pocket [chemical binding]; other site 471473003471 HMMPfam hit to PF00175, Oxidoreductase NAD-binding domain, score 1.2e-13 471473003472 HMMPfam hit to PF00667, FAD binding domain, score 1.7e-07 471473003473 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 471473003474 HMMPfam hit to PF00338, Ribosomal protein S10p/S20e,score 3e-58 471473003475 PS00361 Ribosomal protein S10 signature 471473003476 elongation factor G; Reviewed; Region: PRK12739 471473003477 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 471473003478 G1 box; other site 471473003479 putative GEF interaction site [polypeptide binding]; other site 471473003480 GTP/Mg2+ binding site [chemical binding]; other site 471473003481 Switch I region; other site 471473003482 G2 box; other site 471473003483 G3 box; other site 471473003484 Switch II region; other site 471473003485 G4 box; other site 471473003486 G5 box; other site 471473003487 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 471473003488 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 471473003489 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 471473003490 HMMPfam hit to PF00679, Elongation factor G C-terminus, score 1.8e-44 471473003491 HMMPfam hit to PF03764, Elongation factor G, domain IV, score 6.9e-66 471473003492 HMMPfam hit to PF03144, Elongation factor Tu domain,score 2.1e-18 471473003493 HMMPfam hit to PF00009, Elongation factor Tu GTP binding domain, score 1.2e-107 471473003494 PS00301 GTP-binding elongation factors signature 471473003495 PS00017 ATP/GTP-binding site motif A (P-loop) 471473003496 30S ribosomal protein S7; Validated; Region: PRK05302 471473003497 HMMPfam hit to PF00177, Ribosomal protein S7p/S5e,score 1.5e-95 471473003498 PS00052 Ribosomal protein S7 signature 471473003499 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 471473003500 S17 interaction site [polypeptide binding]; other site 471473003501 S8 interaction site; other site 471473003502 16S rRNA interaction site [nucleotide binding]; other site 471473003503 streptomycin interaction site [chemical binding]; other site 471473003504 23S rRNA interaction site [nucleotide binding]; other site 471473003505 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 471473003506 HMMPfam hit to PF00164, Ribosomal protein S12,score 5e-70 471473003507 PS00055 Ribosomal protein S12 signature 471473003508 2 probable transmembrane helices predicted for CTL0699 by TMHMM2.0 at aa 31-53 and 63-85 471473003509 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 471473003510 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 471473003511 protein binding site [polypeptide binding]; other site 471473003512 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 471473003513 Catalytic dyad [active] 471473003514 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 471473003515 HMMPfam hit to PF00595, PDZ domain (Also known as DHR or GLGF), score 2e-13 471473003516 HMMPfam hit to PF03572, Peptidase family S41, score 2.4e-57 471473003517 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA); Region: CRPA; pfam05745 471473003518 HMMPfam hit to PF05745, Chlamydia 15 kDa cysteine-rich outer membran, score 9.3e-81 471473003519 2 probable transmembrane helices predicted for CTL0701 by TMHMM2.0 at aa 43-65 and 69-88 471473003520 Chlamydia cysteine-rich outer membrane protein 6; Region: Chlam_OMP6; pfam03504 471473003521 Domain of unknown function DUF11; Region: DUF11; pfam01345 471473003522 Domain of unknown function DUF11; Region: DUF11; pfam01345 471473003523 HMMPfam hit to PF01345, Domain of unknown function DUF11, score 3.5e-18 471473003524 HMMPfam hit to PF01345, Domain of unknown function DUF11, score 1.4e-17 471473003525 HMMPfam hit to PF03504, Chlamydia cysteine-rich outer membrane pro, score 1.4e-78 471473003526 1 probable transmembrane helix predicted for CTL0702 by TMHMM2.0 at aa 13-32 471473003527 Chlamydia cysteine-rich outer membrane protein 3; Region: Chlam_OMP3; pfam03503 471473003528 HMMPfam hit to PF03503, Chlamydia cysteine-rich outer membrane pro, score 1.1e-32 471473003529 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 471473003530 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 471473003531 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 471473003532 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 471473003533 HIGH motif; other site 471473003534 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 471473003535 active site 471473003536 KMSKS motif; other site 471473003537 HMMPfam hit to PF00749, tRNA synthetases class I (E and Q), cata, score 3.9e-157 471473003538 PS00178 Aminoacyl-transfer RNA synthetases class-I signature 471473003539 Helix-turn-helix domain; Region: HTH_17; pfam12728 471473003540 Helix-turn-helix domain; Region: HTH_17; cl17695 471473003541 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 471473003542 DHH family; Region: DHH; pfam01368 471473003543 DHHA1 domain; Region: DHHA1; pfam02272 471473003544 HMMPfam hit to PF02272, DHHA1 domain, score 1.1e-13 471473003545 HMMPfam hit to PF01368, DHH family, score 4.8e-43 471473003546 HMMPfam hit to PF02355, Protein export membrane protein, score 3.2e-97 471473003547 12 probable transmembrane helices predicted for CTL0708 by TMHMM2.0 at aa 9-31, 904-921, 923-945,955-977,998-1020, 1035-1057, 1085-1107, 1232-1251,1258-1280,1290-1309, 1340-1362 and 1367-1389 471473003548 PS00141 Eukaryotic and viral aspartyl proteases active site 471473003549 HMMPfam hit to PF07549, SecD/SecF GG Motif, score 0.00038 471473003550 PS00037 Myb DNA-binding domain repeat signature 1 471473003551 2 probable transmembrane helices predicted for CTL0709 by TMHMM2.0 at aa 43-65 and 69-88 471473003552 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2 471473003553 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14840 471473003554 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 471473003555 catalytic residue [active] 471473003556 putative FPP diphosphate binding site; other site 471473003557 putative FPP binding hydrophobic cleft; other site 471473003558 dimer interface [polypeptide binding]; other site 471473003559 putative IPP diphosphate binding site; other site 471473003560 HMMPfam hit to PF01255, Putative undecaprenyl diphosphate syntha, score 4.3e-95 471473003561 PS00962 Ribosomal protein S2 signature 1 471473003562 PS01066 Undecaprenyl pyrophosphate synthetase family signature 471473003563 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 471473003564 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 471473003565 HMMPfam hit to PF01148, Cytidylyltransferase family,score 4.3e-81 471473003566 7 probable transmembrane helices predicted for CTL0711 by TMHMM2.0 at aa 28-50, 71-90, 100-117,124-146,161-183, 203-222 and 232-251 471473003567 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 471473003568 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 471473003569 CMP-binding site; other site 471473003570 The sites determining sugar specificity; other site 471473003571 PS00017 ATP/GTP-binding site motif A (P-loop) 471473003572 HMMPfam hit to PF02224, Cytidylate kinase, score 3.4e-86 471473003573 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 471473003574 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 471473003575 putative acyl-acceptor binding pocket; other site 471473003576 HMMPfam hit to PF01553, Acyltransferase, score 7.1e-26 471473003577 arginine-tRNA ligase; Region: PLN02286 471473003578 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 471473003579 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 471473003580 active site 471473003581 HIGH motif; other site 471473003582 KMSK motif region; other site 471473003583 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 471473003584 tRNA binding surface [nucleotide binding]; other site 471473003585 anticodon binding site; other site 471473003586 HMMPfam hit to PF03485, Arginyl tRNA synthetase N terminal do, score 1.8e-20 471473003587 HMMPfam hit to PF00750, tRNA synthetases class I (R), score 9.5e-110 471473003588 PS00178 Aminoacyl-transfer RNA synthetases class-I signature 471473003589 HMMPfam hit to PF05746, DALR anticodon binding domain, score 6.3e-37 471473003590 PS00527 Ribosomal protein S14 signature 471473003591 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 471473003592 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 471473003593 hinge; other site 471473003594 active site 471473003595 HMMPfam hit to PF00275, EPSP synthase (3-phosphoshikimate 1-car, score 3.6e-118 471473003596 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 471473003597 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 471473003598 HMMPfam hit to PF07577, Domain of Unknown Function (DUF1547), score 2.3e-29 471473003599 HMMPfam hit to PF07577, Domain of Unknown Function (DUF1547), score 3.3e-29 471473003600 DNA-binding regulatory protein, YebC/PmpR family; Region: TIGR01033 471473003601 HMMPfam hit to PF01709, Domain of unknown function DUF28, score 2.7e-134 471473003602 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 471473003603 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471473003604 Coenzyme A binding pocket [chemical binding]; other site 471473003605 HMMPfam hit to PF00583, Acetyltransferase (GNAT) family, score 1.5e-19 471473003606 peptide chain release factor 2; Validated; Region: prfB; PRK00578 471473003607 PCRF domain; Region: PCRF; pfam03462 471473003608 RF-1 domain; Region: RF-1; pfam00472 471473003609 HMMPfam hit to PF00472, Peptidyl-tRNA hydrolase domain, score 7e-75 471473003610 PS00745 Prokaryotic-type class I peptide chain release factors signature 471473003611 HMMPfam hit to PF03462, PCRF domain, score 1.3e-52 471473003612 SWIB-domain-containing proteins implicated in chromatin remodeling [Chromatin structure and dynamics]; Region: COG5531 471473003613 SWI complex, BAF60b domains; Region: SWIB; smart00151 471473003614 HMMPfam hit to PF02201, SWIB/MDM2 domain, score 1.5e-39 471473003615 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 471473003616 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471473003617 putative active site [active] 471473003618 putative metal binding site [ion binding]; other site 471473003619 1 probable transmembrane helix predicted for CTL0721 by TMHMM2.0 at aa 2-24 471473003620 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 5.8e-23 471473003621 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 471473003622 substrate binding site; other site 471473003623 dimer interface; other site 471473003624 HMMPfam hit to PF01128, Uncharacterized protein family UPF0007, score 2.7e-25 471473003625 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 471473003626 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 471473003627 dimerization interface 3.5A [polypeptide binding]; other site 471473003628 active site 471473003629 HMMPfam hit to PF01416, tRNA pseudouridine synthase,score 3.1e-32 471473003630 HMMPfam hit to PF01416, tRNA pseudouridine synthase,score 3e-37 471473003631 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 471473003632 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471473003633 active site 471473003634 motif I; other site 471473003635 motif II; other site 471473003636 HMMPfam hit to PF00702, haloacid dehalogenase-like hydrolase, score 4.8e-22 471473003637 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 471473003638 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 471473003639 PAS domain; Region: PAS; smart00091 471473003640 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471473003641 dimer interface [polypeptide binding]; other site 471473003642 phosphorylation site [posttranslational modification] 471473003643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471473003644 ATP binding site [chemical binding]; other site 471473003645 Mg2+ binding site [ion binding]; other site 471473003646 G-X-G motif; other site 471473003647 HMMPfam hit to PF00512, His Kinase A (phosphoacceptor) domain, score 7.4e-20 471473003648 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and HSP90, score 5.6e-22 471473003649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471473003650 Response regulator receiver domain; Region: Response_reg; pfam00072 471473003651 active site 471473003652 phosphorylation site [posttranslational modification] 471473003653 intermolecular recognition site; other site 471473003654 dimerization interface [polypeptide binding]; other site 471473003655 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471473003656 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 471473003657 Walker A motif; other site 471473003658 ATP binding site [chemical binding]; other site 471473003659 Walker B motif; other site 471473003660 arginine finger; other site 471473003661 HMMPfam hit to PF00072, Response regulator receiver domain, score 1.5e-35 471473003662 HMMPfam hit to PF00158, Sigma-54 interaction domain,score 7e-137 471473003663 PS00688 Sigma-54 interaction domain C-terminal part signature 471473003664 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 471473003665 Recombination protein O N terminal; Region: RecO_N; pfam11967 471473003666 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 471473003667 Recombination protein O C terminal; Region: RecO_C; pfam02565 471473003668 HMMPfam hit to PF02565, Recombination protein O,score 1.4e-131 471473003669 1 probable transmembrane helix predicted for CTL0731 by TMHMM2.0 at aa 7-29 471473003670 Uncharacterized conserved protein [Function unknown]; Region: COG1723 471473003671 HMMPfam hit to PF02582, Uncharacterised ACR, YagE family COG1723, score 5.4e-136 471473003672 hypothetical protein; Provisional; Region: PRK14377 471473003673 HMMPfam hit to PF01809, Domain of unknown function DUF37, score 4e-40 471473003674 1 probable transmembrane helix predicted for CTL0735 by TMHMM2.0 at aa 24-43 471473003675 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 471473003676 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 471473003677 putative tRNA-binding site [nucleotide binding]; other site 471473003678 B3/4 domain; Region: B3_4; pfam03483 471473003679 tRNA synthetase B5 domain; Region: B5; smart00874 471473003680 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 471473003681 dimer interface [polypeptide binding]; other site 471473003682 motif 1; other site 471473003683 motif 3; other site 471473003684 motif 2; other site 471473003685 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 471473003686 HMMPfam hit to PF01588, Putative tRNA binding domain, score 6.1e-36 471473003687 HMMPfam hit to PF03483, B3/4 domain, score 2.2e-77 471473003688 HMMPfam hit to PF03484, tRNA synthetase B5 domain,score 2.4e-24 471473003689 HMMPfam hit to PF03147, Ferredoxin-fold anticodon binding domain, score 1.5e-38 471473003690 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 471473003691 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 471473003692 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 471473003693 DNA binding site [nucleotide binding] 471473003694 active site 471473003695 HMMPfam hit to PF01035, 6-O-methylguanine DNA methyltransferase, score 3.8e-05 471473003696 PS00374 Methylated-DNA--protein-cysteine methyltransferase active site 471473003697 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 471473003698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471473003699 dimer interface [polypeptide binding]; other site 471473003700 conserved gate region; other site 471473003701 putative PBP binding loops; other site 471473003702 ABC-ATPase subunit interface; other site 471473003703 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 3.3e-31 471473003704 8 probable transmembrane helices predicted for CTL0739 by TMHMM2.0 at aa 20-42, 72-94, 101-123,378-400,412-434, 439-461, 490-512 and 546-568 471473003705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471473003706 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471473003707 HMMPfam hit to PF00528, Binding-protein-dependent transport syst, score 1e-27 471473003708 5 probable transmembrane helices predicted for CTL0740 by TMHMM2.0 at aa 239-261, 268-290, 330-347,392-414 and 434-453 471473003709 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 471473003710 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 471473003711 HMMPfam hit to PF00496, Bacterial extracellular solute-binding prot, score 1.5e-21 471473003712 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 471473003713 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 471473003714 putative active site [active] 471473003715 putative metal binding site [ion binding]; other site 471473003716 HMMPfam hit to PF01522, Polysaccharide deacetylase,score 8.5e-05 471473003717 1 probable transmembrane helix predicted for CTL0743 by TMHMM2.0 at aa 12-34 471473003718 2 probable transmembrane helices predicted for CTL0744 by TMHMM2.0 at aa 40-62 and 82-104 471473003719 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471473003720 binding surface 471473003721 TPR motif; other site 471473003722 2 probable transmembrane helices predicted for CTL0745 by TMHMM2.0 at aa 30-52 and 57-79 471473003723 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 471473003724 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 471473003725 C-terminal domain interface [polypeptide binding]; other site 471473003726 active site 471473003727 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 471473003728 active site 471473003729 N-terminal domain interface [polypeptide binding]; other site 471473003730 HMMPfam hit to PF00762, Ferrochelatase, score 8.3e-145 471473003731 PS00534 Ferrochelatase signature 471473003732 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 471473003733 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 471473003734 substrate binding pocket [chemical binding]; other site 471473003735 membrane-bound complex binding site; other site 471473003736 hinge residues; other site 471473003737 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 471473003738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471473003739 S-adenosylmethionine binding site [chemical binding]; other site 471473003740 HMMPfam hit to PF03602, Conserved hypothetical protein, score 4.8e-86 471473003741 PS00092 N-6 Adenine-specific DNA methylases signature 471473003742 Predicted phosphohydrolase [General function prediction only]; Region: COG1768 471473003743 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471473003744 HMMPfam hit to PF00149, Calcineurin-like phosphoesterase, score 2.1e-16 471473003745 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 471473003746 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 471473003747 ligand binding site; other site 471473003748 oligomer interface; other site 471473003749 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471473003750 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 471473003751 N-terminal domain interface [polypeptide binding]; other site 471473003752 sulfate 1 binding site; other site 471473003753 HMMPfam hit to PF00483, Nucleotidyl transferase,score 1.6e-48 471473003754 PS00809 ADP-glucose pyrophosphorylase signature 2 471473003755 transcription termination factor Rho; Region: rho; TIGR00767 471473003756 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 471473003757 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 471473003758 RNA binding site [nucleotide binding]; other site 471473003759 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 471473003760 multimer interface [polypeptide binding]; other site 471473003761 Walker A motif; other site 471473003762 ATP binding site [chemical binding]; other site 471473003763 Walker B motif; other site 471473003764 HMMPfam hit to PF00006, ATP synthase alpha/beta family, nucleoti, score 4.3e-74 471473003765 PS00017 ATP/GTP-binding site motif A (P-loop) 471473003766 HMMPfam hit to PF07497, Rho termination factor,RNA-binding doma, score 4.3e-55 471473003767 HMMPfam hit to PF07498, Rho termination factor,N-terminal domai, score 1.6e-13 471473003768 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 471473003769 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 471473003770 CoA-binding site [chemical binding]; other site 471473003771 ATP-binding [chemical binding]; other site 471473003772 HMMPfam hit to PF01121, Dephospho-CoA kinase, score 1.3e-17 471473003773 PS00017 ATP/GTP-binding site motif A (P-loop) 471473003774 DNA polymerase I; Provisional; Region: PRK05755 471473003775 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 471473003776 active site 471473003777 metal binding site 1 [ion binding]; metal-binding site 471473003778 putative 5' ssDNA interaction site; other site 471473003779 metal binding site 3; metal-binding site 471473003780 metal binding site 2 [ion binding]; metal-binding site 471473003781 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 471473003782 putative DNA binding site [nucleotide binding]; other site 471473003783 putative metal binding site [ion binding]; other site 471473003784 3'-5' exonuclease; Region: 35EXOc; smart00474 471473003785 active site 471473003786 substrate binding site [chemical binding]; other site 471473003787 catalytic site [active] 471473003788 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 471473003789 active site 471473003790 DNA binding site [nucleotide binding] 471473003791 catalytic site [active] 471473003792 HMMPfam hit to PF00476, DNA polymerase family A,score 2.3e-128 471473003793 HMMPfam hit to PF01367, 5'-3' exonuclease,C-terminal SAM fold, score 1e-52 471473003794 HMMPfam hit to PF02739, 5'-3' exonuclease,N-terminal resolvase-, score 5.5e-86 471473003795 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 471473003796 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 471473003797 oligomer interface [polypeptide binding]; other site 471473003798 tandem repeat interface [polypeptide binding]; other site 471473003799 active site residues [active] 471473003800 HMMPfam hit to PF01343, Peptidase family S49, score 1.3e-31 471473003801 1 probable transmembrane helix predicted for CTL0755 by TMHMM2.0 at aa 12-34 471473003802 TLC ATP/ADP transporter; Region: TLC; pfam03219 471473003803 HMMPfam hit to PF03219, TLC ATP/ADP transporter,score 0 471473003804 12 probable transmembrane helices predicted for CTL0756 by TMHMM2.0 at aa 21-43, 58-80, 93-115,148-170,183-205, 220-242, 287-309, 329-351, 358-380,390-409,448-470 and 475-497 471473003805 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 471473003806 HMMPfam hit to PF01066, CDP-alcohol phosphatidyltransferase, score 7.3e-27 471473003807 4 probable transmembrane helices predicted for CTL0757 by TMHMM2.0 at aa 13-35, 82-104, 116-135 and 139-156 471473003808 PS00379 CDP-alcohol phosphatidyltransferases signature 471473003809 1 probable transmembrane helix predicted for CTL0758 by TMHMM2.0 at aa 4-21 471473003810 replicative DNA helicase; Provisional; Region: PRK06321 471473003811 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 471473003812 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 471473003813 Walker A motif; other site 471473003814 ATP binding site [chemical binding]; other site 471473003815 Walker B motif; other site 471473003816 DNA binding loops [nucleotide binding] 471473003817 HMMPfam hit to PF00772, DnaB-like helicase N terminal domain, score 7.9e-37 471473003818 HMMPfam hit to PF03796, DnaB-like helicase C terminal domain, score 8.9e-123 471473003819 PS00017 ATP/GTP-binding site motif A (P-loop) 471473003820 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 471473003821 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 471473003822 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 471473003823 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 471473003824 HMMPfam hit to PF01134, Glucose inhibited division protein A, score 1.8e-242 471473003825 PS00017 ATP/GTP-binding site motif A (P-loop) 471473003826 PS01280 Glucose inhibited division protein A family signature 1 471473003827 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 471473003828 HMMPfam hit to PF03099, Biotin/lipoate A/B protein ligase famil, score 9.3e-10 471473003829 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 471473003830 active site 471473003831 multimer interface [polypeptide binding]; other site 471473003832 HMMPfam hit to PF00334, Nucleoside diphosphate kinase, score 9.4e-73 471473003833 PS00469 Nucleoside diphosphate kinases active site 471473003834 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 471473003835 RuvA N terminal domain; Region: RuvA_N; pfam01330 471473003836 HMMPfam hit to PF01330, RuvA N terminal domain,score 2.5e-25 471473003837 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 471473003838 active site 471473003839 putative DNA-binding cleft [nucleotide binding]; other site 471473003840 dimer interface [polypeptide binding]; other site 471473003841 HMMPfam hit to PF02075, Crossover junction endodeoxyribonuclease Ruv, score 5.4e-67 471473003842 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 471473003843 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 471473003844 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 471473003845 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 471473003846 HMMPfam hit to PF02800, Glyceraldehyde 3-phosphate dehydrogenase, C-, score 1.7e-106 471473003847 PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site 471473003848 HMMPfam hit to PF00044, Glyceraldehyde 3-phosphate dehydrogenase, NA, score 6.7e-88 471473003849 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 471473003850 HMMPfam hit to PF01196, Ribosomal protein L17,score 5.8e-78 471473003851 PS01167 Ribosomal protein L17 signature 471473003852 DNA-directed RNA polymerase, alpha subunit, bacterial and chloroplast-type; Region: rpoA; TIGR02027 471473003853 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 471473003854 alphaNTD - beta interaction site [polypeptide binding]; other site 471473003855 alphaNTD homodimer interface [polypeptide binding]; other site 471473003856 alphaNTD - beta' interaction site [polypeptide binding]; other site 471473003857 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 471473003858 HMMPfam hit to PF03118, Bacterial RNA polymerase,alpha chain C, score 1.7e-34 471473003859 HMMPfam hit to PF01193, RNA polymerase Rpb3/Rpb11 dimerisation, score 2.8e-19 471473003860 HMMPfam hit to PF01000, RNA polymerase Rpb3/RpoA insert domain, score 1.7e-16 471473003861 30S ribosomal protein S11; Validated; Region: PRK05309 471473003862 HMMPfam hit to PF00411, Ribosomal protein S11,score 5.3e-55 471473003863 PS00054 Ribosomal protein S11 signature 471473003864 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 471473003865 30S ribosomal protein S13; Region: bact_S13; TIGR03631 471473003866 HMMPfam hit to PF00416, Ribosomal protein S13/S18,score 2.1e-49 471473003867 PS00646 Ribosomal protein S13 signature 471473003868 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 471473003869 SecY translocase; Region: SecY; pfam00344 471473003870 HMMPfam hit to PF00344, eubacterial secY protein,score 9.3e-212 471473003871 10 probable transmembrane helices predicted for CTL0772 by TMHMM2.0 at aa 17-39, 73-95, 120-142,157-179,192-214, 229-251, 285-307, 317-339, 384-406 and 410-429 471473003872 PS00756 Protein secY signature 2 471473003873 PS00755 Protein secY signature 1 471473003874 ribosomal protein L15, bacterial/organelle; Region: rplO_bact; TIGR01071 471473003875 HMMPfam hit to PF01305, Ribosomal protein L15 amino terminal re, score 1.1e-62 471473003876 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 471473003877 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 471473003878 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 471473003879 HMMPfam hit to PF03719, Ribosomal protein S5,C-terminal domai, score 5.5e-42 471473003880 HMMPfam hit to PF00333, Ribosomal protein S5,N-terminal domai, score 1.3e-37 471473003881 PS00585 Ribosomal protein S5 signature 471473003882 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 471473003883 5S rRNA interface [nucleotide binding]; other site 471473003884 23S rRNA interface [nucleotide binding]; other site 471473003885 L5 interface [polypeptide binding]; other site 471473003886 HMMPfam hit to PF00861, Ribosomal L18p/L5e family,score 8.9e-53 471473003887 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 471473003888 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 471473003889 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 471473003890 HMMPfam hit to PF00347, Ribosomal protein L6, score 3.5e-28 471473003891 PS00525 Ribosomal protein L6 signature 1 471473003892 HMMPfam hit to PF00347, Ribosomal protein L6, score 6.6e-16 471473003893 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 471473003894 HMMPfam hit to PF00410, Ribosomal protein S8, score 4.1e-68 471473003895 PS00053 Ribosomal protein S8 signature 471473003896 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 471473003897 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 471473003898 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 471473003899 HMMPfam hit to PF00673, ribosomal L5P family C-terminus, score 2.6e-27 471473003900 HMMPfam hit to PF00281, Ribosomal protein L5, score 3e-32 471473003901 PS00358 Ribosomal protein L5 signature 471473003902 PS00041 Bacterial regulatory proteins, araC family signature 471473003903 Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Region: RplX; COG0198 471473003904 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 471473003905 RNA binding site [nucleotide binding]; other site 471473003906 HMMPfam hit to PF00467, KOW motif, score 2.2e-08 471473003907 PS01108 Ribosomal protein L24 signature 471473003908 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 471473003909 HMMPfam hit to PF00238, Ribosomal protein L14p/L23e,score 6.5e-80 471473003910 PS00049 Ribosomal protein L14 signature 471473003911 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 471473003912 HMMPfam hit to PF00366, Ribosomal protein S17,score 1e-37 471473003913 PS00056 Ribosomal protein S17 signature 471473003914 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 471473003915 23S rRNA interface [nucleotide binding]; other site 471473003916 putative translocon interaction site; other site 471473003917 signal recognition particle (SRP54) interaction site; other site 471473003918 L23 interface [polypeptide binding]; other site 471473003919 trigger factor interaction site; other site 471473003920 HMMPfam hit to PF00831, Ribosomal L29 protein,score 3.4e-15 471473003921 PS00579 Ribosomal protein L29 signature 471473003922 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 471473003923 23S rRNA interface [nucleotide binding]; other site 471473003924 5S rRNA interface [nucleotide binding]; other site 471473003925 putative antibiotic binding site [chemical binding]; other site 471473003926 L25 interface [polypeptide binding]; other site 471473003927 L27 interface [polypeptide binding]; other site 471473003928 HMMPfam hit to PF00252, Ribosomal protein L16,score 2.6e-82 471473003929 PS00701 Ribosomal protein L16 signature 2 471473003930 PS00586 Ribosomal protein L16 signature 1 471473003931 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 471473003932 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 471473003933 G-X-X-G motif; other site 471473003934 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 471473003935 HMMPfam hit to PF00189, Ribosomal protein S3,C-terminal domai, score 5.7e-49 471473003936 PS00548 Ribosomal protein S3 signature 471473003937 HMMPfam hit to PF07650, KH domain, score 7.2e-24 471473003938 HMMPfam hit to PF00417, Ribosomal protein S3,N-terminal domai, score 2.7e-12 471473003939 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 471473003940 putative translocon binding site; other site 471473003941 protein-rRNA interface [nucleotide binding]; other site 471473003942 HMMPfam hit to PF00237, Ribosomal protein L22p/L17e,score 7.6e-26 471473003943 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 471473003944 HMMPfam hit to PF00203, Ribosomal protein S19,score 2.9e-45 471473003945 PS00323 Ribosomal protein S19 signature 471473003946 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 471473003947 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 471473003948 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 471473003949 HMMPfam hit to PF03947, Ribosomal Proteins L2,C-terminal doma, score 1.3e-80 471473003950 PS00467 Ribosomal protein L2 signature 471473003951 HMMPfam hit to PF00181, Ribosomal Proteins L2, RNA binding dom, score 1.6e-41 471473003952 Ribosomal protein L23 [Translation, ribosomal structure and biogenesis]; Region: RplW; COG0089 471473003953 HMMPfam hit to PF00276, Ribosomal protein L23,score 0.00011 471473003954 PS00215 Mitochondrial energy transfer proteins signature 471473003955 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 471473003956 HMMPfam hit to PF00573, Ribosomal protein L4/L1 family, score 3.3e-88 471473003957 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 471473003958 HMMPfam hit to PF00297, Ribosomal protein L3, score 3.4e-55 471473003959 2 probable transmembrane helices predicted for CTL0791 by TMHMM2.0 at aa 136-158 and 272-294 471473003960 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 471473003961 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 471473003962 putative active site [active] 471473003963 substrate binding site [chemical binding]; other site 471473003964 putative cosubstrate binding site; other site 471473003965 catalytic site [active] 471473003966 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 471473003967 substrate binding site [chemical binding]; other site 471473003968 HMMPfam hit to PF02911, Formyl transferase,C-terminal domain, score 6.1e-46 471473003969 HMMPfam hit to PF00551, Formyl transferase, score 1.6e-31 471473003970 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 471473003971 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 471473003972 active site 471473003973 PS00101 Hexapeptide-repeat containing-transferases signature 471473003974 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 37 471473003975 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 11 471473003976 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 7.9 471473003977 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.0041 471473003978 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 4.4 471473003979 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.77 471473003980 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 53 471473003981 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 0.12 471473003982 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 471473003983 HMMPfam hit to PF07977, FabA-like domain, score 6.5e-59 471473003984 1 probable transmembrane helix predicted for CTL0794 by TMHMM2.0 at aa 60-82 471473003985 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; COG0774 471473003986 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 471473003987 HMMPfam hit to PF03331, UDP-3-O-acyl N-acetylglycosamine deacetylase, score 3.3e-178 471473003988 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 471473003989 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 471473003990 putative active site [active] 471473003991 catalytic triad [active] 471473003992 putative dimer interface [polypeptide binding]; other site 471473003993 7 probable transmembrane helices predicted for CTL0796 by TMHMM2.0 at aa 24-46, 55-74, 84-106,113-135,161-183, 190-207 and 509-531 471473003994 HMMPfam hit to PF00795, Carbon-nitrogen hydrolase,score 4e-48 471473003995 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 471473003996 HMMPfam hit to PF03061, Thioesterase superfamily,score 3.4e-14 471473003997 DNA polymerase III subunit epsilon; Validated; Region: PRK06310 471473003998 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 471473003999 active site 471473004000 catalytic site [active] 471473004001 substrate binding site [chemical binding]; other site 471473004002 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 471473004003 HMMPfam hit to PF00929, Exonuclease, score 3.9e-54 471473004004 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 471473004005 HMMPfam hit to PF02367, Uncharacterised P-loop hydrolase UPF0079, score 1.6e-62 471473004006 PS00017 ATP/GTP-binding site motif A (P-loop) 471473004007 Protein of unknown function (DUF2709); Region: DUF2709; pfam10915 471473004008 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471473004009 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471473004010 catalytic residues [active] 471473004011 HMMPfam hit to PF00085, Thioredoxin, score 1.1e-38 471473004012 PS00194 Thioredoxin family active site 471473004013 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 471473004014 HMMPfam hit to PF00588, SpoU rRNA Methylase family,score 8e-43 471473004015 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 471473004016 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 471473004017 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 471473004018 HMMPfam hit to PF00254, FKBP-type peptidyl-prolyl cis-trans isomeras, score 3.2e-34 471473004019 PS00454 FKBP-type peptidyl-prolyl cis-trans isomerase signature 2 471473004020 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1 471473004021 HMMPfam hit to PF01346, Domain amino terminal to FKBP-type peptidyl-, score 1e-05 471473004022 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 471473004023 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 471473004024 dimer interface [polypeptide binding]; other site 471473004025 anticodon binding site; other site 471473004026 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 471473004027 homodimer interface [polypeptide binding]; other site 471473004028 motif 1; other site 471473004029 active site 471473004030 motif 2; other site 471473004031 GAD domain; Region: GAD; pfam02938 471473004032 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 471473004033 active site 471473004034 motif 3; other site 471473004035 HMMPfam hit to PF00152, tRNA synthetases class II (D, K and N), score 2.1e-199 471473004036 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2 471473004037 HMMPfam hit to PF02938, GAD domain, score 4.2e-43 471473004038 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1 471473004039 HMMPfam hit to PF01336, OB-fold nucleic acid binding domain, score 2.1e-21 471473004040 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 471473004041 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 471473004042 dimer interface [polypeptide binding]; other site 471473004043 motif 1; other site 471473004044 active site 471473004045 motif 2; other site 471473004046 motif 3; other site 471473004047 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 471473004048 anticodon binding site; other site 471473004049 HMMPfam hit to PF03129, Anticodon binding domain,score 8e-08 471473004050 HMMPfam hit to PF00587, tRNA synthetase class II core domain (, score 3e-47 471473004051 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 471473004052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471473004053 putative substrate translocation pore; other site 471473004054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471473004055 10 probable transmembrane helices predicted for CTL0806 by TMHMM2.0 at aa 29-48, 68-90, 103-125,183-205,263-282, 302-321, 334-351, 361-383, 390-412 and 422-444 471473004056 HMMPfam hit to PF07690, Major Facilitator Superfamily, score 2.2e-64 471473004057 PS00942 glpT family of transporters signature 471473004058 PS00340 Growth factor and cytokines receptors family signature 2 471473004059 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 471473004060 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 471473004061 active site 471473004062 PHP Thumb interface [polypeptide binding]; other site 471473004063 metal binding site [ion binding]; metal-binding site 471473004064 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 471473004065 generic binding surface I; other site 471473004066 generic binding surface II; other site 471473004067 HMMPfam hit to PF02811, PHP domain, score 1.4e-65 471473004068 HMMPfam hit to PF07733, Bacterial DNA polymerase III alpha sub, score 7.7e-271 471473004069 TPR repeat; Region: TPR_11; pfam13414 471473004070 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471473004071 binding surface 471473004072 TPR motif; other site 471473004073 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 471473004074 HMMPfam hit to PF00515, Tetratricopeptide repeat,score 0.02 471473004075 HMMPfam hit to PF00515, Tetratricopeptide repeat,score 0.3 471473004076 HMMPfam hit to PF07719, Tetratricopeptide repeat,score 0.0021 471473004077 1 probable transmembrane helix predicted for CTL0810 by TMHMM2.0 at aa 5-27 471473004078 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 471473004079 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 471473004080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471473004081 Mg2+ binding site [ion binding]; other site 471473004082 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 471473004083 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 471473004084 2 probable transmembrane helices predicted for CTL0813 by TMHMM2.0 at aa 5-24 and 397-419 471473004085 HMMPfam hit to PF00768, D-alanyl-D-alanine carboxypeptidase, score 9.6e-23 471473004086 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 471473004087 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471473004088 S-adenosylmethionine binding site [chemical binding]; other site 471473004089 HMMPfam hit to PF01189, NOL1/NOP2/sun family, score 2.8e-09 471473004090 branched-chain amino acid uptake carrier; Region: livcs; TIGR00796 471473004091 HMMPfam hit to PF05525, Branched-chain amino acid transport p, score 5.6e-15 471473004092 10 probable transmembrane helices predicted for CTL0817 by TMHMM2.0 at aa 12-34, 44-66, 87-109,124-143,150-171, 202-221, 251-273, 302-324, 336-358 and 363-385 471473004093 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 471473004094 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471473004095 ATP binding site [chemical binding]; other site 471473004096 putative Mg++ binding site [ion binding]; other site 471473004097 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471473004098 ATP-binding site [chemical binding]; other site 471473004099 HMMPfam hit to PF04434, SWIM zinc finger, score 0.00011 471473004100 HMMPfam hit to PF00176, SNF2 family N-terminal domain, score 5.6e-57 471473004101 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 6.2e-18 471473004102 2 probable transmembrane helices predicted for CTL0819 by TMHMM2.0 at aa 99-121 and 136-153 471473004103 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 471473004104 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 471473004105 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471473004106 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471473004107 HMMPfam hit to PF03486, HI0933-like protein, score 0.00088 471473004108 HMMPfam hit to PF01134, Glucose inhibited division protein A, score 3.8e-18 471473004109 HMMPfam hit to PF07992, Pyridine nucleotide-disulphide oxidored, score 9.6e-77 471473004110 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site 471473004111 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidored, score 2.3e-32 471473004112 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidored, score 1e-48 471473004113 lipoate synthase; Region: lipA; TIGR00510 471473004114 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471473004115 FeS/SAM binding site; other site 471473004116 HMMPfam hit to PF04055, Radical SAM superfamily,score 2.2e-17 471473004117 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 471473004118 HMMPfam hit to PF01514, Secretory protein of YscJ/FliF family, score 6.4e-32 471473004119 1 probable transmembrane helix predicted for CTL0822 by TMHMM2.0 at aa 236-258 471473004120 type III secretion system protein; Validated; Region: PRK06328 471473004121 Flagellar assembly protein FliH; Region: FliH; pfam02108 471473004122 type III secretion system protein; Reviewed; Region: PRK09617 471473004123 5 probable transmembrane helices predicted for CTL0825 by TMHMM2.0 at aa 7-29, 93-115, 135-157, 245-267 and 274-296 471473004124 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 471473004125 HMMPfam hit to PF00813, FliP family, score 1.9e-73 471473004126 PS01061 Flagella transport protein fliP family signature 2 471473004127 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 471473004128 HMMPfam hit to PF01313, Bacterial export proteins,family, score 5.2e-27 471473004129 2 probable transmembrane helices predicted for CTL0826 by TMHMM2.0 at aa 20-42 and 62-84 471473004130 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 471473004131 HMMPfam hit to PF01311, Bacterial export proteins,family, score 1e-14 471473004132 6 probable transmembrane helices predicted for CTL0827 by TMHMM2.0 at aa 26-48, 52-74, 87-109,145-167,203-225 and 240-262 471473004133 2 probable transmembrane helices predicted for CTL0828 by TMHMM2.0 at aa 50-72 and 113-135 471473004134 Protein of unknown function (DUF1494); Region: DUF1494; pfam07379 471473004135 HMMPfam hit to PF07379, Protein of unknown function (DUF1494), score 4.2e-134 471473004136 1 probable transmembrane helix predicted for CTL0830 by TMHMM2.0 at aa 12-34 471473004137 1 probable transmembrane helix predicted for CTL0831 by TMHMM2.0 at aa 20-42 471473004138 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 471473004139 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 471473004140 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 471473004141 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 471473004142 3 probable transmembrane helices predicted for CTL0833 by TMHMM2.0 at aa 160-182, 207-229 and 364-386 471473004143 HMMPfam hit to PF00482, Bacterial type II secretion system protein F, score 7.6e-18 471473004144 HMMPfam hit to PF00482, Bacterial type II secretion system protein F, score 1.8e-21 471473004145 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 471473004146 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 471473004147 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 471473004148 Walker A motif; other site 471473004149 ATP binding site [chemical binding]; other site 471473004150 Walker B motif; other site 471473004151 HMMPfam hit to PF00437, Type II/IV secretion system protein, score 4.9e-116 471473004152 PS00662 Bacterial type II secretion system protein E signature 471473004153 PS00017 ATP/GTP-binding site motif A (P-loop) 471473004154 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 471473004155 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 471473004156 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 471473004157 HMMPfam hit to PF00263, Bacterial type II and III secretion system, score 6.6e-58 471473004158 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 2.2e-09 471473004159 HMMPfam hit to PF03958, Bacterial type II/III secretion system sho, score 4.8e-10 471473004160 1 probable transmembrane helix predicted for CTL0835 by TMHMM2.0 at aa 5-27 471473004161 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 471473004162 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 471473004163 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 471473004164 active site 471473004165 HMMPfam hit to PF00557, metallopeptidase family M24,score 4.6e-63 471473004166 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 471473004167 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471473004168 ATP binding site [chemical binding]; other site 471473004169 Mg2+ binding site [ion binding]; other site 471473004170 G-X-G motif; other site 471473004171 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 471473004172 ATP binding site [chemical binding]; other site 471473004173 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 471473004174 HMMPfam hit to PF01119, DNA mismatch repair protein,C-termina, score 4.5e-47 471473004175 HMMPfam hit to PF02518, Histidine kinase-, DNA gyrase B-, and, score 9.9e-07 471473004176 PS00058 DNA mismatch repair proteins mutL / hexB / PMS1 signature 471473004177 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 471473004178 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471473004179 binding surface 471473004180 TPR motif; other site 471473004181 HMMPfam hit to PF07720, Tetratricopeptide repeat,score 4.7e-08 471473004182 HMMPfam hit to PF07720, Tetratricopeptide repeat,score 2 471473004183 pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362 471473004184 1 probable transmembrane helix predicted for CTL0841 by TMHMM2.0 at aa 256-278 471473004185 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 471473004186 EamA-like transporter family; Region: EamA; pfam00892 471473004187 EamA-like transporter family; Region: EamA; pfam00892 471473004188 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 5.8e-19 471473004189 10 probable transmembrane helices predicted for CTL0843 by TMHMM2.0 at aa 13-35, 50-72, 85-107,117-134,143-162, 172-194, 207-229, 239-261, 268-290 and 295-314 471473004190 HMMPfam hit to PF00892, Integral membrane protein DUF6, score 9.3e-25 471473004191 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 471473004192 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cd01616 471473004193 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 471473004194 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 471473004195 active site 471473004196 dimer interface [polypeptide binding]; other site 471473004197 motif 1; other site 471473004198 motif 2; other site 471473004199 motif 3; other site 471473004200 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 471473004201 anticodon binding site; other site 471473004202 HMMPfam hit to PF02824, TGS domain, score 1.8e-15 471473004203 HMMPfam hit to PF07973, Threonyl and Alanyl tRNA synthetase se, score 2.3e-21 471473004204 HMMPfam hit to PF00587, tRNA synthetase class II core domain (, score 3.2e-65 471473004205 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1 471473004206 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2 471473004207 HMMPfam hit to PF03129, Anticodon binding domain,score 9.3e-29 471473004208 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 471473004209 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 471473004210 HMMPfam hit to PF01656, CobQ/CobB/MinD/ParA nucleotide binding domai, score 5.7e-37 471473004211 Uncharacterized protein family (UPF0137); Region: UPF0137; pfam03677 471473004212 HMMPfam hit to PF03677, Uncharacterised protein family (UPF0137), score 1.2e-155 471473004213 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 471473004214 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 471473004215 active site 471473004216 HIGH motif; other site 471473004217 dimer interface [polypeptide binding]; other site 471473004218 KMSKS motif; other site 471473004219 HMMPfam hit to PF00579, tRNA synthetases class I (W and Y), score 2.1e-109 471473004220 excinuclease ABC subunit B; Provisional; Region: PRK05298 471473004221 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471473004222 ATP binding site [chemical binding]; other site 471473004223 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471473004224 nucleotide binding region [chemical binding]; other site 471473004225 ATP-binding site [chemical binding]; other site 471473004226 Ultra-violet resistance protein B; Region: UvrB; pfam12344 471473004227 HMMPfam hit to PF04851, Type III restriction enzyme,res subunit, score 9.1e-06 471473004228 PS00017 ATP/GTP-binding site motif A (P-loop) 471473004229 HMMPfam hit to PF00271, Helicase conserved C-terminal domain, score 2e-19 471473004230 HMMPfam hit to PF02151, UvrB/uvrC motif, score 1.9e-06 471473004231 enolase; Provisional; Region: eno; PRK00077 471473004232 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 471473004233 dimer interface [polypeptide binding]; other site 471473004234 metal binding site [ion binding]; metal-binding site 471473004235 substrate binding pocket [chemical binding]; other site 471473004236 HMMPfam hit to PF03952, Enolase, N-terminal domain,score 2e-56 471473004237 HMMPfam hit to PF00113, Enolase, C-terminal TIM barrel domain, score 8.2e-146 471473004238 PS00164 Enolase signature 471473004239 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 471473004240 HAMP domain; Region: HAMP; pfam00672 471473004241 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 471473004242 2 probable transmembrane helices predicted for CTL0851 by TMHMM2.0 at aa 20-42 and 316-335 471473004243 HMMPfam hit to PF00672, HAMP domain, score 4.2e-09 471473004244 HMMPfam hit to PF07228, Stage II sporulation protein E (SpoIIE), score 9e-61 471473004245 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 471473004246 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 471473004247 1 probable transmembrane helix predicted for CTL0852 by TMHMM2.0 at aa 9-31 471473004248 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 471473004249 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 471473004250 HMMPfam hit to PF00037, 4Fe-4S binding domain,score 0.0064 471473004251 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature 471473004252 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 471473004253 L-aspartate oxidase; Provisional; Region: PRK06175 471473004254 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 471473004255 HMMPfam hit to PF02910, Fumarate reductase/succinate dehydroge, score 2.4e-47 471473004256 HMMPfam hit to PF00890, FAD binding domain, score 3.8e-85 471473004257 PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site 471473004258 this CDS carries multiple frameshfift mutations. The sequence has been checked and is believed to be correct 471473004259 5 probable transmembrane helices predicted for CTL0856 by TMHMM2.0 at aa 19-41, 65-87, 115-137, 220-242 and 262-284 471473004260 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 471473004261 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 471473004262 active site 471473004263 HMMPfam hit to PF04909, Amidohydrolase, score 0.0016 471473004264 HMMPfam hit to PF01026, TatD related DNase, score 6.6e-106 471473004265 PS01091 Uncharacterized protein family UPF0006 signature 3 471473004266 PS01090 Uncharacterized protein family UPF0006 signature 2 471473004267 Uncharacterized protein predicted to be involved in C-type cytochrome biogenesis [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4233 471473004268 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 471473004269 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 471473004270 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 471473004271 DsbD alpha interface [polypeptide binding]; other site 471473004272 catalytic residues [active] 471473004273 PS00194 Thioredoxin family active site 471473004274 8 probable transmembrane helices predicted for CTL0859 by TMHMM2.0 at aa 287-309, 330-352,367-389,416-438, 453-472, 493-510, 514-536 and 549-571 471473004275 HMMPfam hit to PF02683, Cytochrome C biogenesis protein transmembran, score 5.2e-05 471473004276 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 471473004277 3 probable transmembrane helices predicted for CTL0860 by TMHMM2.0 at aa 22-39, 141-163 and 178-200 471473004278 HMMPfam hit to PF01618, MotA/TolQ/ExbB proton channel family, score 2e-51 471473004279 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 471473004280 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 471473004281 HMMPfam hit to PF02472, Biopolymer transport protein ExbD/TolR, score 0.00021 471473004282 1 probable transmembrane helix predicted for CTL0861 by TMHMM2.0 at aa 15-37 471473004283 1 probable transmembrane helix predicted for CTL0861A by TMHMM2.0 at aa 7-29 471473004284 translocation protein TolB; Provisional; Region: tolB; PRK01029 471473004285 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 471473004286 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 471473004287 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 471473004288 HMMPfam hit to PF04052, TolB amino-terminal domain,score 1.5e-54 471473004289 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 9.7e-05 471473004290 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 2.4e-08 471473004291 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 2.6e-05 471473004292 HMMPfam hit to PF07676, WD40-like Beta Propeller Repeat, score 0.28 471473004293 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 471473004294 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 471473004295 ligand binding site [chemical binding]; other site 471473004296 PS00013 Prokaryotic membrane lipoprotein lipid attachment site 471473004297 HMMPfam hit to PF00691, OmpA family, score 2.7e-26 471473004298 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 471473004299 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471473004300 HMMPfam hit to PF01476, LysM domain, score 6.1e-17 471473004301 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 471473004302 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 471473004303 dimer interface [polypeptide binding]; other site 471473004304 decamer (pentamer of dimers) interface [polypeptide binding]; other site 471473004305 catalytic triad [active] 471473004306 peroxidatic and resolving cysteines [active] 471473004307 HMMPfam hit to PF00578, AhpC/TSA family, score 2.3e-87 471473004308 HMMPfam hit to PF08534, Redoxin, score 3.5e-10 471473004309 Chaperonin GroEL (HSP60 family) [Posttranslational modification, protein turnover, chaperones]; Region: GroL; COG0459 471473004310 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 471473004311 HMMPfam hit to PF00118, TCP-1/cpn60 chaperonin family, score 7.9e-131 471473004312 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3876 471473004313 HMMPfam hit to PF07075, Protein of unknown function (DUF1343), score 2.4e-231 471473004314 1 probable transmembrane helix predicted for CTL0868 by TMHMM2.0 at aa 7-26 471473004315 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 471473004316 active site 471473004317 dimerization interface [polypeptide binding]; other site 471473004318 HMMPfam hit to PF01725, Ham1 family, score 3.9e-43 471473004319 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 471473004320 ligand binding site [chemical binding]; other site 471473004321 active site 471473004322 UGI interface [polypeptide binding]; other site 471473004323 catalytic site [active] 471473004324 HMMPfam hit to PF03167, Uracil DNA glycosylase superfamily, score 8e-76 471473004325 PS00130 Uracil-DNA glycosylase signature 471473004326 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 471473004327 Part of AAA domain; Region: AAA_19; pfam13245 471473004328 Family description; Region: UvrD_C_2; pfam13538 471473004329 HMMPfam hit to PF00580, UvrD/REP helicase, score 6.3e-222 471473004330 PS00017 ATP/GTP-binding site motif A (P-loop) 471473004331 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog [Transcription]; Region: RpoN; COG1508 471473004332 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 471473004333 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 471473004334 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 471473004335 HMMPfam hit to PF00309, Sigma-54 factor, Activator interacting do, score 1e-17 471473004336 HMMPfam hit to PF04963, Sigma-54 factor, core binding domain, score 4.9e-08 471473004337 HMMPfam hit to PF04552, Sigma-54, DNA binding domain, score 3.9e-77 471473004338 PS00718 Sigma-54 factors family signature 2 471473004339 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 471473004340 HMMPfam hit to PF03070, TENA/THI-4/PQQC family,score 5.9e-76 471473004341 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 471473004342 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 471473004343 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 471473004344 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 471473004345 folate binding site [chemical binding]; other site 471473004346 NADP+ binding site [chemical binding]; other site 471473004347 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 471473004348 catalytic center binding site [active] 471473004349 ATP binding site [chemical binding]; other site 471473004350 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 471473004351 dihydropteroate synthase; Region: DHPS; TIGR01496 471473004352 substrate binding pocket [chemical binding]; other site 471473004353 dimer interface [polypeptide binding]; other site 471473004354 inhibitor binding site; inhibition site 471473004355 PS00017 ATP/GTP-binding site motif A (P-loop) 471473004356 PS00794 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature 471473004357 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 471473004358 homooctamer interface [polypeptide binding]; other site 471473004359 active site 471473004360 HMMPfam hit to PF02152, Dihydroneopterin aldolase,score 4e-47 471473004361 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 471473004362 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 471473004363 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 471473004364 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471473004365 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 471473004366 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471473004367 DNA binding residues [nucleotide binding] 471473004368 HMMPfam hit to PF04545, Sigma-70, region, score 1.1e-23 471473004369 PS00716 Sigma-70 factors family signature 2 471473004370 HMMPfam hit to PF04539, Sigma-70 region, score 4.2e-36 471473004371 HMMPfam hit to PF04542, Sigma-70 region, score 2.4e-28 471473004372 PS00715 Sigma-70 factors family signature 1 471473004373 PS00030 Eukaryotic putative RNA-binding region RNP-1 signature 471473004374 HMMPfam hit to PF00140, Sigma-70 factor,region,score 2.2e-18 471473004375 HMMPfam hit to PF03979, Sigma-70 factor,region,score 3.8e-24 471473004376 Uncharacterized protein family (UPF0242); Region: UPF0242; pfam06785 471473004377 HMMPfam hit to PF06785, Uncharacterised protein family (UPF0242), score 0 471473004378 2 probable transmembrane helices predicted for CTL0880 by TMHMM2.0 at aa 34-56 and 61-83 471473004379 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 471473004380 HMMPfam hit to PF01649, Ribosomal protein S20,score 1.3e-15 471473004381 2 probable transmembrane helices predicted for CTL0882 by TMHMM2.0 at aa 213-235 and 240-262 471473004382 Effector from type III secretion system; Region: Effector_1; pfam04518 471473004383 HMMPfam hit to PF04518, Protein of unknown function,DUF582, score 1.5e-179 471473004384 Effector from type III secretion system; Region: Effector_1; pfam04518 471473004385 HMMPfam hit to PF04518, Protein of unknown function,DUF582, score 1.2e-207 471473004386 Effector from type III secretion system; Region: Effector_1; pfam04518 471473004387 HMMPfam hit to PF04518, Protein of unknown function,DUF582, score 5e-209 471473004388 PS00962 Ribosomal protein S2 signature 1 471473004389 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 471473004390 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 471473004391 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 471473004392 MviN-like protein; Region: MVIN; pfam03023 471473004393 13 probable transmembrane helices predicted for CTL0888 by TMHMM2.0 at aa 20-42, 86-108, 118-140,147-166,176-198, 221-243, 258-280, 300-322, 342-364,371-393,398-420, 441-463 and 478-500 471473004394 HMMPfam hit to PF03023, MviN-like protein, score 1.3e-187 471473004395 endonuclease IV; Provisional; Region: PRK01060 471473004396 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 471473004397 AP (apurinic/apyrimidinic) site pocket; other site 471473004398 DNA interaction; other site 471473004399 Metal-binding active site; metal-binding site 471473004400 HMMPfam hit to PF01261, Xylose isomerase-like TIM barrel, score 8.2e-51 471473004401 PS00730 AP endonucleases family 2 signature 2 471473004402 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 471473004403 ribosomal protein S4, bacterial/organelle type; Region: rpsD_bact; TIGR01017 471473004404 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471473004405 RNA binding surface [nucleotide binding]; other site 471473004406 HMMPfam hit to PF01479, S4 domain, score 2.2e-20 471473004407 HMMPfam hit to PF00163, Ribosomal protein S4/S9 N-terminal domai, score 1.2e-16 471473004408 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 471473004409 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 471473004410 active site residue [active] 471473004411 HMMPfam hit to PF00581, Rhodanese-like domain,score 1.6e-11 471473004412 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 471473004413 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 471473004414 substrate binding pocket [chemical binding]; other site 471473004415 chain length determination region; other site 471473004416 substrate-Mg2+ binding site; other site 471473004417 catalytic residues [active] 471473004418 aspartate-rich region 1; other site 471473004419 active site lid residues [active] 471473004420 aspartate-rich region 2; other site 471473004421 HMMPfam hit to PF00348, Polyprenyl synthetase,score 3.2e-29 471473004422 PS00444 Polyprenyl synthetases signature 2 471473004423 PS00723 Polyprenyl synthetases signature 1 471473004424 Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636 471473004425 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 1.2 471473004426 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 58 471473004427 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 4.2 471473004428 HMMPfam hit to PF00132, Bacterial transferase hexapeptide (three rep, score 3 471473004429 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471473004430 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471473004431 DNA binding site [nucleotide binding] 471473004432 HMMPfam hit to PF00486, Transcriptional regulatory protein, C ter, score 2.6e-20 471473004433 Predicted alternative thymidylate synthase [Nucleotide transport and metabolism]; Region: THY1; COG1351 471473004434 Thymidylate synthase complementing protein; Region: Thy1; cl03630