-- dump date 20140619_040236 -- class Genbank::misc_feature -- table misc_feature_note -- id note 218497000001 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 218497000002 dimer interface [polypeptide binding]; other site 218497000003 active site 218497000004 aspartate-rich active site metal binding site; other site 218497000005 allosteric magnesium binding site [ion binding]; other site 218497000006 Schiff base residues; other site 218497000007 Pfam match to entry PF00490 ALAD, Delta-aminolevulinic acid dehydratase , score 551.8, E-value 2.9e-163 218497000008 PS00169 Delta-aminolevulinic acid dehydratase active site. 218497000009 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrA [Energy production and conversion]; Region: NqrA; COG1726 218497000010 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 218497000011 transcript cleavage factor/unknown domain fusion protein; Validated; Region: PRK06330 218497000012 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 218497000013 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 218497000014 Pfam match to entry PF03449 GreA_GreB_N, Prokaryotic transcription elongation factor, GreA/GreB, N-terminal domain , score 29.9, E-value 1.9e-06 218497000015 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 218497000016 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218497000017 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218497000018 homodimer interface [polypeptide binding]; other site 218497000019 catalytic residue [active] 218497000020 Pfam match to entry PF00155 aminotran_1_2, Aminotransferase class I and II , score 164.4, E-value 1.2e-46 218497000021 rod shape-determining protein MreC; Provisional; Region: PRK14872 218497000022 rod shape-determining protein MreC; Region: MreC; pfam04085 218497000023 1 probable transmembrane helix predicted for CAB006 by TMHMM2.0 at aa 68-85 218497000024 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 218497000025 Part of AAA domain; Region: AAA_19; pfam13245 218497000026 Family description; Region: UvrD_C_2; pfam13538 218497000027 Pfam match to entry PF00580 UvrD-helicase, UvrD/REP helicase , score 361.3, E-value 6.5e-106 218497000028 PS00017 ATP/GTP-binding site motif A (P-loop). 218497000029 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 218497000030 H+ Antiporter protein; Region: 2A0121; TIGR00900 218497000031 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218497000032 putative substrate translocation pore; other site 218497000033 10 probable transmembrane helices predicted for CAB009 by TMHMM2.0 at aa 17-39, 52-74, 95-117, 177-199, 231-253, 268-290, 295-317, 322-344, 357-379 and 389-408 218497000034 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 218497000035 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 218497000036 active site residue [active] 218497000037 Pfam match to entry PF00581 Rhodanese, Rhodanese-like domain , score 53.3, E-value 3.5e-13 218497000038 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 218497000039 ribosomal protein S4, bacterial/organelle type; Region: rpsD_bact; TIGR01017 218497000040 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 218497000041 RNA binding surface [nucleotide binding]; other site 218497000042 Pfam match to entry PF00163 Ribosomal_S4, Ribosomal protein S4/S9 N-terminal domain , score 73.5, E-value 2.9e-19 218497000043 Pfam match to entry PF01479 S4, S4 domain , score 75.0, E-value 1e-19 218497000044 endonuclease IV; Provisional; Region: PRK01060 218497000045 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 218497000046 AP (apurinic/apyrimidinic) site pocket; other site 218497000047 DNA interaction; other site 218497000048 Metal-binding active site; metal-binding site 218497000049 Pfam match to entry PF01261 AP_endonuc_2, AP endonuclease 2 , score 318.5, E-value 5.1e-93 218497000050 PS00730 AP endonucleases family 2 signature 2. 218497000051 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 218497000052 MviN-like protein; Region: MVIN; pfam03023 218497000053 13 probable transmembrane helices predicted for CAB013 by TMHMM2.0 at aa 33-52, 96-118, 128-150, 157-176, 186-208, 229-248, 268-290, 310-332, 352-374, 381-403, 408-427, 448-470 and 490-512 218497000054 Pfam match to entry PF03023 MVIN, Virulence factor MVIN , score 547.7, E-value 5.3e-162 218497000055 Signal peptide predicted for CAB014 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.981 between residues 23 and 24 218497000056 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 218497000057 Effector from type III secretion system; Region: Effector_1; pfam04518 218497000058 Effector from type III secretion system; Region: Effector_1; pfam04518 218497000059 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 218497000060 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 218497000061 Walker A/P-loop; other site 218497000062 ATP binding site [chemical binding]; other site 218497000063 Q-loop/lid; other site 218497000064 ABC transporter signature motif; other site 218497000065 Walker B; other site 218497000066 D-loop; other site 218497000067 H-loop/switch region; other site 218497000068 Pfam match to entry PF00005 ABC_tran, ABC transporter , score 172.2, E-value 5.7e-49 218497000069 PS00211 ABC transporters family signature. 218497000070 PS00017 ATP/GTP-binding site motif A (P-loop). 218497000071 Protein of unknown function (DUF1137); Region: DUF1137; pfam06587 218497000072 Signal peptide predicted for CAB020 by SignalP 2.0 HMM (Signal peptide probabilty 0.965) with cleavage site probability 0.644 between residues 25 and 26 218497000073 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218497000074 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 218497000075 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 218497000076 Pfam match to entry PF00793 DAHP_synth_1, DAHP synthetase I family , score 440.1, E-value 1.2e-129 218497000077 hypothetical protein; Provisional; Region: PRK01064 218497000078 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 218497000079 G-X-X-G motif; other site 218497000080 Pfam match to entry PF00013 KH, KH domain , score 21.6, E-value 0.00063 218497000081 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 218497000082 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 218497000083 RNA binding surface [nucleotide binding]; other site 218497000084 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 218497000085 active site 218497000086 Pfam match to entry PF00849 PseudoU_synth_2, RNA pseudouridylate synthase , score 236.6, E-value 2.2e-68 218497000087 Pfam match to entry PF01479 S4, S4 domain , score 44.4, E-value 1.7e-10 218497000088 DNA topoisomerase IV subunit A; Provisional; Region: PRK09630 218497000089 CAP-like domain; other site 218497000090 DNA gyrase/topoisomerase IV, subunit A; Region: DNA_topoisoIV; pfam00521 218497000091 active site 218497000092 Pfam match to entry PF00521 DNA_topoisoIV, DNA gyrase/topoisomerase IV, subunit A , score 159.9, E-value 2.8e-45 218497000093 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 218497000094 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218497000095 ATP binding site [chemical binding]; other site 218497000096 Mg2+ binding site [ion binding]; other site 218497000097 G-X-G motif; other site 218497000098 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 218497000099 ATP binding site [chemical binding]; other site 218497000100 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 218497000101 active site 218497000102 putative metal-binding site [ion binding]; other site 218497000103 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 218497000104 Pfam match to entry PF01751 Toprim, Toprim domain , score 18.7, E-value 7.2e-05 218497000105 Pfam match to entry PF00204 DNA_gyraseB, DNA gyrase B , score 92.9, E-value 4.1e-25 218497000106 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase , score 52.2, E-value 7.6e-13 218497000107 glutamyl-tRNA reductase; Validated; Region: hemA; PRK00676 218497000108 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 218497000109 NAD(P) binding pocket [chemical binding]; other site 218497000110 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 218497000111 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 218497000112 phosphopeptide binding site; other site 218497000113 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 218497000114 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 218497000115 phosphopeptide binding site; other site 218497000116 BON domain; Region: BON; pfam04972 218497000117 Pfam match to entry PF00498 FHA, FHA domain , score 41.0, E-value 1.8e-09 218497000118 Pfam match to entry PF00498 FHA, FHA domain , score 53.5, E-value 3.1e-13 218497000119 1 probable transmembrane helix predicted for CAB031 by TMHMM2.0 at aa 494-516 218497000120 type III secretion system ATPase; Provisional; Region: PRK06315 218497000121 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 218497000122 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 218497000123 Walker A motif/ATP binding site; other site 218497000124 Walker B motif; other site 218497000125 Pfam match to entry PF02874 ATP-synt_ab_N, ATP synthase alpha/beta family, beta-barrel domain , score 38.1, E-value 1.3e-08 218497000126 Pfam match to entry PF00006 ATP-synt_ab, ATP synthase alpha/beta family, nucleotide-binding domain , score 498.1, E-value 4.3e-147 218497000127 PS00017 ATP/GTP-binding site motif A (P-loop). 218497000128 PS00152 ATP synthase alpha and beta subunits signature. 218497000129 type III secretion system protein; Validated; Region: PRK05933 218497000130 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 218497000131 Pfam match to entry PF01052 SpoA, Surface presentation of antigens (SPOA) protein , score 50.0, E-value 3.5e-12 218497000132 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 218497000133 Catalytic domain of Protein Kinases; Region: PKc; cd00180 218497000134 active site 218497000135 ATP binding site [chemical binding]; other site 218497000136 substrate binding site [chemical binding]; other site 218497000137 activation loop (A-loop); other site 218497000138 Pfam match to entry PF00069 pkinase, Protein kinase domain , score 164.7, E-value 1e-46 218497000139 PS00108 Serine/Threonine protein kinases active-site signature. 218497000140 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 218497000141 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 218497000142 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 218497000143 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 218497000144 Signal peptide predicted for CAB041 by SignalP 2.0 HMM (Signal peptide probabilty 0.858) with cleavage site probability 0.423 between residues 38 and 39 218497000145 Pfam match to entry PF00263 GSPII_III, Bacterial type II and III secretion system protein , score 282.3, E-value 4e-82 218497000146 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 218497000147 ATP:guanido phosphotransferase, C-terminal catalytic domain; Region: ATP-gua_Ptrans; pfam00217 218497000148 ADP binding site [chemical binding]; other site 218497000149 phosphagen binding site; other site 218497000150 substrate specificity loop; other site 218497000151 Pfam match to entry PF00217 ATP-gua_Ptrans, ATP:guanido phosphotransferase, C-terminal catalytic domain , score -94.5, E-value 0.00042 218497000152 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 218497000153 UvrB/uvrC motif; Region: UVR; pfam02151 218497000154 Pfam match to entry PF02151 UVR, UvrB/uvrC motif , score 34.1, E-value 2.1e-07 218497000155 ribosome recycling factor; Reviewed; Region: frr; PRK00083 218497000156 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 218497000157 hinge region; other site 218497000158 Pfam match to entry PF01765 RRF, Ribosome recycling factor , score 253.6, E-value 1.7e-73 218497000159 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 218497000160 putative nucleotide binding site [chemical binding]; other site 218497000161 uridine monophosphate binding site [chemical binding]; other site 218497000162 homohexameric interface [polypeptide binding]; other site 218497000163 Pfam match to entry PF00696 aakinase, Amino acid kinase , score 181.0, E-value 1.3e-51 218497000164 elongation factor Ts; Provisional; Region: tsf; PRK09377 218497000165 UBA/TS-N domain; Region: UBA; pfam00627 218497000166 Elongation factor TS; Region: EF_TS; pfam00889 218497000167 Elongation factor TS; Region: EF_TS; pfam00889 218497000168 Pfam match to entry PF00889 EF_TS, Elongation factor TS , score 326.7, E-value 1.8e-95 218497000169 PS01127 Elongation factor Ts signature 2. 218497000170 Pfam match to entry PF00627 UBA, UBA/TS-N domain , score 40.6, E-value 2.3e-09 218497000171 PS01126 Elongation factor Ts signature 1. 218497000172 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 218497000173 rRNA interaction site [nucleotide binding]; other site 218497000174 S8 interaction site; other site 218497000175 Pfam match to entry PF00318 Ribosomal_S2, Ribosomal protein S2 , score 306.7, E-value 1.8e-89 218497000176 PS00963 Ribosomal protein S2 signature 2. 218497000177 PS00962 Ribosomal protein S2 signature 1. 218497000178 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 218497000179 Pfam match to entry PF01308 Chlamydia_OMP, Chlamydia major outer membrane protein , score 970.8, E-value 2.2e-289 218497000180 Signal peptide predicted for CAB048 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.932 between residues 22 and 23 218497000181 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 218497000182 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 218497000183 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 218497000184 Signal peptide predicted for CAB049 by SignalP 2.0 HMM (Signal peptide probabilty 0.665) with cleavage site probability 0.279 between residues 42 and 43 218497000185 Pfam match to entry PF03717 PBP_dimer, Penicillin-binding Protein dimerisation domain , score 158.2, E-value 9.4e-45 218497000186 Pfam match to entry PF00905 Transpeptidase, Penicillin binding protein transpeptidase domain , score 22.7, E-value 1.2e-06 218497000187 Pfam match to entry PF00905 Transpeptidase, Penicillin binding protein transpeptidase domain , score -32.1, E-value 2.9e-08 218497000188 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 218497000189 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 218497000190 binding surface 218497000191 TPR motif; other site 218497000192 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 218497000193 binding surface 218497000194 TPR motif; other site 218497000195 Tetratricopeptide repeat; Region: TPR_16; pfam13432 218497000196 Pfam match to entry PF00515 TPR, TPR Domain , score 8.7, E-value 0.34 218497000197 Pfam match to entry PF00515 TPR, TPR Domain , score 23.3, E-value 0.00037 218497000198 Pfam match to entry PF00515 TPR, TPR Domain , score 1.6, E-value 2 218497000199 Pfam match to entry PF00515 TPR, TPR Domain , score 46.2, E-value 4.8e-11 218497000200 Pfam match to entry PF00515 TPR, TPR Domain , score 16.8, E-value 0.034 218497000201 Pfam match to entry PF00515 TPR, TPR Domain , score 31.9, E-value 9.3e-07 218497000202 Pfam match to entry PF00515 TPR, TPR Domain , score 34.8, E-value 1.3e-07 218497000203 Pfam match to entry PF00515 TPR, TPR Domain , score 25.3, E-value 9e-05 218497000204 Pfam match to entry PF00515 TPR, TPR Domain , score 8.7, E-value 0.34 218497000205 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 218497000206 putative ABC transporter; Region: ycf24; CHL00085 218497000207 Pfam match to entry PF01458 UPF0051, Uncharacterized protein family (UPF0051) , score 430.1, E-value 1.3e-126 218497000208 FeS assembly ATPase SufC; Region: sufC; TIGR01978 218497000209 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 218497000210 Walker A/P-loop; other site 218497000211 ATP binding site [chemical binding]; other site 218497000212 Q-loop/lid; other site 218497000213 ABC transporter signature motif; other site 218497000214 Walker B; other site 218497000215 D-loop; other site 218497000216 H-loop/switch region; other site 218497000217 Pfam match to entry PF00005 ABC_tran, ABC transporter , score 104.7, E-value 1.2e-28 218497000218 PS00017 ATP/GTP-binding site motif A (P-loop). 218497000219 FeS assembly protein SufD; Region: sufD; TIGR01981 218497000220 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 218497000221 Pfam match to entry PF01458 UPF0051, Uncharacterized protein family (UPF0051) , score 78.0, E-value 1.3e-20 218497000222 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 218497000223 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 218497000224 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 218497000225 catalytic residue [active] 218497000226 Pfam match to entry PF00266 aminotran_5, Aminotransferase class-V , score 57.8, E-value 1.6e-14 218497000227 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 218497000228 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 218497000229 PS00017 ATP/GTP-binding site motif A (P-loop). 218497000230 1 probable transmembrane helix predicted for CAB056 by TMHMM2.0 at aa 15-37 218497000231 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 218497000232 ParB-like nuclease domain; Region: ParBc; pfam02195 218497000233 Pfam match to entry PF02195 ParBc, ParB-like nuclease domain , score 125.9, E-value 4.7e-35 218497000234 Predicted helix-turn-helix motif with score 1525.000, SD 4.38 at aa 129-150, sequence LTQDKVAVRVGKKRSTVANYLR 218497000235 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 218497000236 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218497000237 Walker A/P-loop; other site 218497000238 ATP binding site [chemical binding]; other site 218497000239 Q-loop/lid; other site 218497000240 ABC transporter signature motif; other site 218497000241 Walker B; other site 218497000242 D-loop; other site 218497000243 H-loop/switch region; other site 218497000244 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 218497000245 Pfam match to entry PF00005 ABC_tran, ABC transporter , score 192.7, E-value 3.8e-55 218497000246 PS00211 ABC transporters family signature. 218497000247 PS00017 ATP/GTP-binding site motif A (P-loop). 218497000248 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 218497000249 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218497000250 Walker A/P-loop; other site 218497000251 ATP binding site [chemical binding]; other site 218497000252 Q-loop/lid; other site 218497000253 ABC transporter signature motif; other site 218497000254 Walker B; other site 218497000255 D-loop; other site 218497000256 H-loop/switch region; other site 218497000257 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 218497000258 Pfam match to entry PF00005 ABC_tran, ABC transporter , score 185.1, E-value 7.5e-53 218497000259 PS00211 ABC transporters family signature. 218497000260 PS00017 ATP/GTP-binding site motif A (P-loop). 218497000261 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 218497000262 Pfam match to entry PF01865 DUF47, Protein of unknown function DUF47 , score 255.5, E-value 4.7e-74 218497000263 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 218497000264 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 218497000265 11 probable transmembrane helices predicted for CAB061 by TMHMM2.0 at aa 2-21, 83-105, 112-134, 138-160, 181-203, 207-224, 260-282, 308-330, 351-370, 374-396 and 403-425 218497000266 Pfam match to entry PF01384 PHO4, Phosphate transporter family , score 584.6, E-value 4.1e-173 218497000267 Phosphoglycerate kinase; Region: PGK; pfam00162 218497000268 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 218497000269 substrate binding site [chemical binding]; other site 218497000270 hinge regions; other site 218497000271 ADP binding site [chemical binding]; other site 218497000272 catalytic site [active] 218497000273 Pfam match to entry PF00162 PGK, Phosphoglycerate kinase , score 651.6, E-value 2.6e-193 218497000274 PS00111 Phosphoglycerate kinase signature. 218497000275 Similar to many including: Chlamydophila caviae nol1/nop2/sun family protein cca00065 SWALL:Q824S4 (EMBL:AE016994) (371 aa) fasta scores: E(): 3.1e-126, 85.67% id in 370 aa and to Plasmodium yoelii yoelii RNA methyltransferase, py03774 SWALL:Q7RI56 (EMBL:AABL01001110) (376 aa) fasta scores: E(): 1.2e-26, 36.38% id in 382 aa. Note this CDS carries multiple frameshift mutations and lacks an appropriate translational start codon;conserved hypothetical protein (pseudogene) 218497000276 Pfam match to entry PF01189 Nol1_Nop2_Sun, NOL1/NOP2/sun family , score 38.1, E-value 1e-09 218497000277 Signal peptide predicted for CAB068 by SignalP 2.0 HMM (Signal peptide probabilty 0.993) with cleavage site probability 0.722 between residues 20 and 21 218497000278 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 218497000279 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 218497000280 1 probable transmembrane helix predicted for CAB069 by TMHMM2.0 at aa 401-418 218497000281 Pfam match to entry PF00768 Peptidase_S11, D-alanyl-D-alanine carboxypeptidase , score 87.4, E-value 1.9e-23 218497000282 Signal peptide predicted for CAB069 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 24 and 25 218497000283 Similar to Chlamydia trachomatis hypothetical protein Ct550 SWALL:O84554 (EMBL:AE001325) (141 aa) fasta scores: E(): 1.5e-20, 64.04% id in 89 aa. Only significant full-length database matches are to predicted Chlamydiaceae proteins. The CDS contains a probable frameshift mutation following codon 94.;conserved hypothetical protein (pseudogene) 218497000284 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 218497000285 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 218497000286 ATP binding site [chemical binding]; other site 218497000287 Mg2+ binding site [ion binding]; other site 218497000288 G-X-G motif; other site 218497000289 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase , score 28.1, E-value 1.3e-05 218497000290 Signal peptide predicted for CAB072 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.749 between residues 22 and 23 218497000291 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218497000292 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 218497000293 binding surface 218497000294 Tetratricopeptide repeat; Region: TPR_16; pfam13432 218497000295 TPR motif; other site 218497000296 Pfam match to entry PF00515 TPR, TPR Domain , score 14.3, E-value 0.084 218497000297 Pfam match to entry PF00515 TPR, TPR Domain , score 11.1, E-value 0.19 218497000298 Pfam match to entry PF00515 TPR, TPR Domain , score 14.2, E-value 0.087 218497000299 Pfam match to entry PF00515 TPR, TPR Domain , score 5.4, E-value 0.78 218497000300 Signal peptide predicted for CAB073 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.995 between residues 20 and 21 218497000301 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218497000302 1 probable transmembrane helix predicted for CAB074 by TMHMM2.0 at aa 5-22 218497000303 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 218497000304 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 218497000305 active site 218497000306 PHP Thumb interface [polypeptide binding]; other site 218497000307 metal binding site [ion binding]; metal-binding site 218497000308 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 218497000309 generic binding surface I; other site 218497000310 generic binding surface II; other site 218497000311 PS00017 ATP/GTP-binding site motif A (P-loop). 218497000312 Pfam match to entry PF02811 PHP_C, PHP domain C-terminal region , score 136.7, E-value 2.8e-38 218497000313 Pfam match to entry PF02231 PHP_N, PHP domain N-terminal region , score 119.9, E-value 3.2e-33 218497000314 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 218497000315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218497000316 putative substrate translocation pore; other site 218497000317 10 probable transmembrane helices predicted for CAB076 by TMHMM2.0 at aa 29-48, 68-90, 103-125, 186-205, 263-282, 302-321, 334-351, 361-383, 390-412 and 422-444 218497000318 PS00942 glpT family of transporters signature. 218497000319 PS00340 Growth factor and cytokines receptors family signature 2. 218497000320 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 218497000321 Signal peptide predicted for CAB077 by SignalP 2.0 HMM (Signal peptide probabilty 0.625) with cleavage site probability 0.513 between residues 19 and 20 218497000322 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 218497000323 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 218497000324 dimer interface [polypeptide binding]; other site 218497000325 motif 1; other site 218497000326 active site 218497000327 motif 2; other site 218497000328 motif 3; other site 218497000329 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 218497000330 anticodon binding site; other site 218497000331 Pfam match to entry PF00587 tRNA-synt_2b, tRNA synthetase class II core domain (G, H, P, S and T) , score 149.0, E-value 5.4e-42 218497000332 Pfam match to entry PF03129 HGTP_anticodon, Anticodon binding domain , score 47.9, E-value 1.5e-11 218497000333 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 218497000334 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 218497000335 dimer interface [polypeptide binding]; other site 218497000336 anticodon binding site; other site 218497000337 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 218497000338 homodimer interface [polypeptide binding]; other site 218497000339 motif 1; other site 218497000340 active site 218497000341 motif 2; other site 218497000342 GAD domain; Region: GAD; pfam02938 218497000343 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 218497000344 active site 218497000345 motif 3; other site 218497000346 PS00527 Ribosomal protein S14 signature. 218497000347 Pfam match to entry PF01336 tRNA_anti, OB-fold nucleic acid binding domain , score 79.3, E-value 5e-21 218497000348 Pfam match to entry PF00152 tRNA-synt_2, tRNA synthetases class II (D, K and N) , score 80.5, E-value 2.3e-21 218497000349 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 218497000350 Pfam match to entry PF02938 GAD, GAD domain , score 157.1, E-value 2e-44 218497000351 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218497000352 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 218497000353 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 218497000354 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 218497000355 Signal peptide predicted for CAB080 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.916 between residues 20 and 21 218497000356 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218497000357 Pfam match to entry PF01346 FKBP_N, Domain amino terminal to FKBP-type peptidyl-prolyl isomerase , score 20.1, E-value 8.3e-05 218497000358 Pfam match to entry PF00254 FKBP, FKBP-type peptidyl-prolyl cis-trans isomerase , score 109.3, E-value 4.8e-30 218497000359 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 218497000360 Pfam match to entry PF00588 SpoU_methylase, SpoU rRNA Methylase , score 101.6, E-value 1e-27 218497000361 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 218497000362 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 218497000363 catalytic residues [active] 218497000364 Pfam match to entry PF00085 thiored, Thioredoxin , score 140.1, E-value 2.6e-39 218497000365 PS00194 Thioredoxin family active site. 218497000366 Protein of unknown function (DUF2709); Region: DUF2709; pfam10915 218497000367 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 218497000368 Pfam match to entry PF02367 UPF0079, Uncharacterised P-loop hydrolase UPF0079 , score 165.7, E-value 4.9e-47 218497000369 PS00017 ATP/GTP-binding site motif A (P-loop). 218497000370 DNA polymerase III subunit epsilon; Validated; Region: PRK06310 218497000371 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 218497000372 active site 218497000373 catalytic site [active] 218497000374 substrate binding site [chemical binding]; other site 218497000375 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 218497000376 Pfam match to entry PF00929 Exonuclease, Exonuclease , score 193.6, E-value 2e-55 218497000377 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 218497000378 Pfam match to entry PF01662 Acyl-CoA_hydro, Cytosolic long-chain acyl-CoA thioester hydrolase , score 88.7, E-value 7.9e-24 218497000379 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 218497000380 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 218497000381 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 218497000382 putative active site [active] 218497000383 catalytic triad [active] 218497000384 putative dimer interface [polypeptide binding]; other site 218497000385 Signal peptide predicted for CAB087 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.965 between residues 17 and 18 218497000386 7 probable transmembrane helices predicted for CAB087 by TMHMM2.0 at aa 22-41, 48-70, 85-107, 116-135, 160-182, 189-206 and 513-535 218497000387 Pfam match to entry PF00795 CN_hydrolase, Carbon-nitrogen hydrolase , score -95.1, E-value 0.0014 218497000388 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 218497000389 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 218497000390 Pfam match to entry PF03331 LpxC, UDP-3-O-acyl N-acetylglycosamine deacetylase , score 571.5, E-value 3.6e-169 218497000391 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 218497000392 Pfam match to entry PF01377 Thioester_dehyd, Thioester dehydrase , score 154.9, E-value 8.8e-44 218497000393 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 218497000394 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 218497000395 active site 218497000396 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats) , score 16.3, E-value 0.049 218497000397 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats) , score 5.1, E-value 11 218497000398 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats) , score 17.3, E-value 0.024 218497000399 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats) , score 16.2, E-value 0.053 218497000400 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats) , score 19.3, E-value 0.0061 218497000401 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats) , score 14.3, E-value 0.19 218497000402 PS00101 Hexapeptide-repeat containing-transferases signature. 218497000403 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats) , score 15.1, E-value 0.11 218497000404 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 218497000405 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 218497000406 putative active site [active] 218497000407 substrate binding site [chemical binding]; other site 218497000408 putative cosubstrate binding site; other site 218497000409 catalytic site [active] 218497000410 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 218497000411 substrate binding site [chemical binding]; other site 218497000412 Pfam match to entry PF00551 formyl_transf, Formyl transferase , score 140.0, E-value 2.8e-39 218497000413 Pfam match to entry PF02911 formyl_trans_C, Formyl transferase, C-terminal domain , score 135.1, E-value 8.4e-38 218497000414 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 218497000415 Pfam match to entry PF00297 Ribosomal_L3, Ribosomal protein L3 , score 198.9, E-value 5.3e-57 218497000416 PS00474 Ribosomal protein L3 signature. 218497000417 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 218497000418 Pfam match to entry PF00573 Ribosomal_L4, Ribosomal protein L4/L1 family , score 234.2, E-value 1.2e-67 218497000419 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 218497000420 PS00215 Mitochondrial energy transfer proteins signature. 218497000421 Pfam match to entry PF00276 Ribosomal_L23, Ribosomal protein L23 , score 22.4, E-value 5.6e-05 218497000422 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 218497000423 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 218497000424 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 218497000425 Pfam match to entry PF00181 Ribosomal_L2, Ribosomal Proteins L2, RNA binding domain , score 162.2, E-value 5.8e-46 218497000426 Pfam match to entry PF03947 Ribosomal_L2_C, Ribosomal Proteins L2, C-terminal domain , score 269.9, E-value 2.2e-78 218497000427 PS00467 Ribosomal protein L2 signature. 218497000428 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 218497000429 Pfam match to entry PF00203 Ribosomal_S19, Ribosomal protein S19 , score 157.0, E-value 2.2e-44 218497000430 PS00323 Ribosomal protein S19 signature. 218497000431 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 218497000432 putative translocon binding site; other site 218497000433 protein-rRNA interface [nucleotide binding]; other site 218497000434 Pfam match to entry PF00237 Ribosomal_L22, Ribosomal protein L22p/L17e , score 83.3, E-value 3.2e-22 218497000435 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 218497000436 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 218497000437 G-X-X-G motif; other site 218497000438 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 218497000439 Pfam match to entry PF00417 Ribosomal_S3_N, Ribosomal protein S3, N-terminal domain , score 60.7, E-value 2e-15 218497000440 Pfam match to entry PF00013 KH, KH domain , score 28.3, E-value 1.1e-05 218497000441 Pfam match to entry PF00189 Ribosomal_S3_C, Ribosomal protein S3, C-terminal domain , score 178.0, E-value 1e-50 218497000442 PS00548 Ribosomal protein S3 signature. 218497000443 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 218497000444 23S rRNA interface [nucleotide binding]; other site 218497000445 5S rRNA interface [nucleotide binding]; other site 218497000446 putative antibiotic binding site [chemical binding]; other site 218497000447 L25 interface [polypeptide binding]; other site 218497000448 L27 interface [polypeptide binding]; other site 218497000449 Pfam match to entry PF00252 Ribosomal_L16, Ribosomal protein L16 , score 269.5, E-value 2.9e-78 218497000450 PS00586 Ribosomal protein L16 signature 1. 218497000451 PS00701 Ribosomal protein L16 signature 2. 218497000452 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 218497000453 23S rRNA interface [nucleotide binding]; other site 218497000454 putative translocon interaction site; other site 218497000455 signal recognition particle (SRP54) interaction site; other site 218497000456 L23 interface [polypeptide binding]; other site 218497000457 trigger factor interaction site; other site 218497000458 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 218497000459 Pfam match to entry PF00366 Ribosomal_S17, Ribosomal protein S17 , score 114.4, E-value 1.4e-31 218497000460 PS00056 Ribosomal protein S17 signature. 218497000461 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 218497000462 Pfam match to entry PF00238 Ribosomal_L14, Ribosomal protein L14p/L23e , score 271.2, E-value 8.8e-79 218497000463 PS00049 Ribosomal protein L14 signature. 218497000464 Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Region: RplX; COG0198 218497000465 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 218497000466 RNA binding site [nucleotide binding]; other site 218497000467 Pfam match to entry PF00467 KOW, KOW motif , score 44.2, E-value 1.9e-10 218497000468 PS01108 Ribosomal protein L24 signature. 218497000469 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 218497000470 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 218497000471 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 218497000472 Pfam match to entry PF00281 Ribosomal_L5, Ribosomal protein L5 , score 115.1, E-value 8.4e-32 218497000473 PS00358 Ribosomal protein L5 signature. 218497000474 Pfam match to entry PF00673 Ribosomal_L5_C, ribosomal L5P family C-terminus , score 107.9, E-value 1.3e-29 218497000475 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 218497000476 Pfam match to entry PF00410 Ribosomal_S8, Ribosomal protein S8 , score 217.9, E-value 9.5e-63 218497000477 PS00053 Ribosomal protein S8 signature. 218497000478 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00294 Prenyl group binding site (CAAX box). 218497000479 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 218497000480 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 218497000481 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 218497000482 Pfam match to entry PF00347 Ribosomal_L6, Ribosomal protein L6 , score 60.8, E-value 2e-15 218497000483 Pfam match to entry PF00347 Ribosomal_L6, Ribosomal protein L6 , score 108.4, E-value 8.8e-30 218497000484 PS00525 Ribosomal protein L6 signature 1. 218497000485 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 218497000486 5S rRNA interface [nucleotide binding]; other site 218497000487 23S rRNA interface [nucleotide binding]; other site 218497000488 L5 interface [polypeptide binding]; other site 218497000489 Pfam match to entry PF00861 Ribosomal_L18p, Ribosomal L18p/L5e family , score 150.5, E-value 1.9e-42 218497000490 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 218497000491 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 218497000492 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 218497000493 Pfam match to entry PF00333 Ribosomal_S5, Ribosomal protein S5, N-terminal domain , score 132.3, E-value 5.7e-37 218497000494 PS00585 Ribosomal protein S5 signature. 218497000495 Pfam match to entry PF03719 Ribosomal_S5_C, Ribosomal protein S5, C-terminal domain , score 129.8, E-value 3.2e-36 218497000496 ribosomal protein L15, bacterial/organelle; Region: rplO_bact; TIGR01071 218497000497 Pfam match to entry PF01305 Ribosomal_L15, Ribosomal protein L15 amino terminal region , score 205.8, E-value 4.3e-59 218497000498 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 218497000499 SecY translocase; Region: SecY; pfam00344 218497000500 10 probable transmembrane helices predicted for CAB110 by TMHMM2.0 at aa 17-39, 74-96, 117-134, 161-183, 190-212, 232-254, 284-306, 326-345, 384-406 and 410-429 218497000501 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218497000502 Pfam match to entry PF00344 secY, eubacterial secY protein , score 635.8, E-value 1.5e-188 218497000503 PS00755 Protein secY signature 1. 218497000504 PS00756 Protein secY signature 2. 218497000505 PS00307 Legume lectins beta-chain signature. 218497000506 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 218497000507 30S ribosomal protein S13; Region: bact_S13; TIGR03631 218497000508 Pfam match to entry PF00416 Ribosomal_S13, Ribosomal protein S13/S18 , score 178.5, E-value 7.2e-51 218497000509 PS00435 Peroxidases proximal heme-ligand signature. 218497000510 PS00646 Ribosomal protein S13 signature. 218497000511 30S ribosomal protein S11; Validated; Region: PRK05309 218497000512 Pfam match to entry PF00411 Ribosomal_S11, Ribosomal protein S11 , score 190.9, E-value 1.4e-54 218497000513 PS00054 Ribosomal protein S11 signature. 218497000514 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 218497000515 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 218497000516 alphaNTD - beta interaction site [polypeptide binding]; other site 218497000517 alphaNTD homodimer interface [polypeptide binding]; other site 218497000518 alphaNTD - beta' interaction site [polypeptide binding]; other site 218497000519 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 218497000520 Pfam match to entry PF01000 RNA_pol_A_bac, Bacterial RNA polymerase, alpha chain, N terminal domain , score 360.1, E-value 1.6e-105 218497000521 Pfam match to entry PF03118 RNA_pol_A_CTD, Bacterial RNA polymerase, alpha chain C terminal domain , score 125.2, E-value 8.1e-35 218497000522 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 218497000523 Pfam match to entry PF01196 Ribosomal_L17, Ribosomal protein L17 , score 248.3, E-value 6.9e-72 218497000524 PS01167 Ribosomal protein L17 signature. 218497000525 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 218497000526 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 218497000527 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 218497000528 Pfam match to entry PF00044 gpdh, Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain , score 319.8, E-value 2.1e-93 218497000529 PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 218497000530 Pfam match to entry PF02800 gpdh_C, Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain , score 394.6, E-value 6.2e-116 218497000531 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 218497000532 active site 218497000533 putative DNA-binding cleft [nucleotide binding]; other site 218497000534 dimer interface [polypeptide binding]; other site 218497000535 Pfam match to entry PF02075 RuvC, Crossover junction endodeoxyribonuclease RuvC , score 260.4, E-value 1.6e-75 218497000536 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 218497000537 RuvA N terminal domain; Region: RuvA_N; pfam01330 218497000538 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 218497000539 Pfam match to entry PF01330 RuvA, RuvA N terminal domain , score 86.9, E-value 2.7e-23 218497000540 Pfam match to entry PF02904 RuvA_II, RuvA central domain II , score 136.9, E-value 2.4e-38 218497000541 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 218497000542 active site 218497000543 multimer interface [polypeptide binding]; other site 218497000544 Pfam match to entry PF00334 NDK, Nucleoside diphosphate kinase , score 253.5, E-value 1.9e-73 218497000545 PS00469 Nucleoside diphosphate kinases active site. 218497000546 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 218497000547 Pfam match to entry PF03099 BPL_LipA_LipB, Biotin/lipoate A/B protein ligase , score 59.1, E-value 6.4e-15 218497000548 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 218497000549 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 218497000550 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 218497000551 Pfam match to entry PF01134 GIDA, Glucose inhibited division protein A , score 1089.9, E-value 0 218497000552 PS01280 Glucose inhibited division protein A family signature 1. 218497000553 PS00017 ATP/GTP-binding site motif A (P-loop). 218497000554 replicative DNA helicase; Provisional; Region: PRK06321 218497000555 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 218497000556 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 218497000557 Walker A motif; other site 218497000558 ATP binding site [chemical binding]; other site 218497000559 Walker B motif; other site 218497000560 DNA binding loops [nucleotide binding] 218497000561 Pfam match to entry PF03796 DnaB_C, DnaB-like helicase C terminal domain , score 406.5, E-value 1.7e-119 218497000562 PS00017 ATP/GTP-binding site motif A (P-loop). 218497000563 Pfam match to entry PF00772 DnaB, DnaB-like helicase N terminal domain , score 122.8, E-value 4.1e-34 218497000564 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 218497000565 Pfam match to entry PF01066 CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase , score 94.4, E-value 1.5e-25 218497000566 PS00379 CDP-alcohol phosphatidyltransferases signature. 218497000567 4 probable transmembrane helices predicted for CAB124 by TMHMM2.0 at aa 54-76, 86-108, 115-137 and 141-160 218497000568 TLC ATP/ADP transporter; Region: TLC; pfam03219 218497000569 PS00430 TonB-dependent receptor proteins signature 1. 218497000570 Pfam match to entry PF03219 TLC, TLC ATP/ADP transporter , score 925.3, E-value 1.1e-275 218497000571 11 probable transmembrane helices predicted for CAB125 by TMHMM2.0 at aa 27-44, 64-86, 93-115, 149-171, 184-206, 221-243, 301-323, 343-360, 367-389, 399-418 and 485-507 218497000572 PS00659 Glycosyl hydrolases family 5 signature. 218497000573 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 218497000574 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 218497000575 tandem repeat interface [polypeptide binding]; other site 218497000576 oligomer interface [polypeptide binding]; other site 218497000577 active site residues [active] 218497000578 Signal peptide predicted for CAB126 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.227 between residues 41 and 42 218497000579 Pfam match to entry PF01343 Peptidase_U7, Peptidase U7 , score 94.4, E-value 1.5e-25 218497000580 DNA polymerase I; Provisional; Region: PRK05755 218497000581 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 218497000582 active site 218497000583 metal binding site 1 [ion binding]; metal-binding site 218497000584 putative 5' ssDNA interaction site; other site 218497000585 metal binding site 3; metal-binding site 218497000586 metal binding site 2 [ion binding]; metal-binding site 218497000587 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 218497000588 putative DNA binding site [nucleotide binding]; other site 218497000589 putative metal binding site [ion binding]; other site 218497000590 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 218497000591 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 218497000592 active site 218497000593 DNA binding site [nucleotide binding] 218497000594 catalytic site [active] 218497000595 Pfam match to entry PF02739 5_3_exonuc_N, 5'-3' exonuclease, N-terminal resolvase-like domain , score 258.1, E-value 7.5e-75 218497000596 Pfam match to entry PF01367 5_3_exonuclease, 5'-3' exonuclease, C-terminal SAM fold , score 143.5, E-value 2.4e-40 218497000597 Pfam match to entry PF00476 DNA_pol_A, DNA polymerase A , score 450.8, E-value 7.4e-133 218497000598 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 218497000599 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 218497000600 CoA-binding site [chemical binding]; other site 218497000601 ATP-binding [chemical binding]; other site 218497000602 Pfam match to entry PF01121 CoaE, Dephospho-CoA kinase , score 85.3, E-value 8.1e-23 218497000603 PS00017 ATP/GTP-binding site motif A (P-loop). 218497000604 transcription termination factor Rho; Provisional; Region: rho; PRK09376 218497000605 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 218497000606 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 218497000607 RNA binding site [nucleotide binding]; other site 218497000608 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 218497000609 multimer interface [polypeptide binding]; other site 218497000610 Walker A motif; other site 218497000611 ATP binding site [chemical binding]; other site 218497000612 Walker B motif; other site 218497000613 Pfam match to entry PF00006 ATP-synt_ab, ATP synthase alpha/beta family, nucleotide-binding domain , score 289.8, E-value 2.2e-84 218497000614 PS00017 ATP/GTP-binding site motif A (P-loop). 218497000615 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 218497000616 active site 218497000617 Pfam match to entry PF00156 Pribosyltran, Phosphoribosyl transferase domain , score 74.0, E-value 2.1e-19 218497000618 glucose-1-phosphate adenylyltransferase; Region: glgC; TIGR02091 218497000619 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 218497000620 ligand binding site; other site 218497000621 oligomer interface; other site 218497000622 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 218497000623 dimer interface [polypeptide binding]; other site 218497000624 N-terminal domain interface [polypeptide binding]; other site 218497000625 sulfate 1 binding site; other site 218497000626 Pfam match to entry PF00483 NTP_transferase, Nucleotidyl transferase , score 154.1, E-value 1.6e-43 218497000627 PS00809 ADP-glucose pyrophosphorylase signature 2. 218497000628 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats) , score 7.7, E-value 5 218497000629 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats) , score 13.3, E-value 0.39 218497000630 Deinococcus radiodurans DR1119 and related proteins, metallophosphatase domain; Region: MPP_DR1119; cd07393 218497000631 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 218497000632 putative active site [active] 218497000633 putative metal binding site [ion binding]; other site 218497000634 Pfam match to entry PF00149 Metallophos, Calcineurin-like phosphoesterase , score 65.5, E-value 7.2e-17 218497000635 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 218497000636 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218497000637 S-adenosylmethionine binding site [chemical binding]; other site 218497000638 Pfam match to entry PF03602 Cons_hypoth95, Conserved hypothetical protein 95 , score 242.8, E-value 3.1e-70 218497000639 PS00017 ATP/GTP-binding site motif A (P-loop). 218497000640 PS00092 N-6 Adenine-specific DNA methylases signature. 218497000641 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 218497000642 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218497000643 substrate binding pocket [chemical binding]; other site 218497000644 membrane-bound complex binding site; other site 218497000645 hinge residues; other site 218497000646 Signal peptide predicted for CAB135 by SignalP 2.0 HMM (Signal peptide probabilty 0.980) with cleavage site probability 0.471 between residues 24 and 25 218497000647 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218497000648 Pfam match to entry PF00497 SBP_bac_3, Bacterial extracellular solute-binding proteins, family 3 , score 77.2, E-value 2.2e-20 218497000649 ferrochelatase; Reviewed; Region: hemH; PRK00035 218497000650 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 218497000651 C-terminal domain interface [polypeptide binding]; other site 218497000652 active site 218497000653 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 218497000654 active site 218497000655 N-terminal domain interface [polypeptide binding]; other site 218497000656 Pfam match to entry PF00762 Ferrochelatase, Ferrochelatase , score 410.5, E-value 1e-120 218497000657 PS00534 Ferrochelatase signature. 218497000658 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 218497000659 TPR motif; other site 218497000660 binding surface 218497000661 2 probable transmembrane helices predicted for CAB137 by TMHMM2.0 at aa 30-52 and 59-81 218497000662 2 probable transmembrane helices predicted for CAB138 by TMHMM2.0 at aa 36-58 and 78-100 218497000663 PS00043 Bacterial regulatory proteins, gntR family signature. 218497000664 Signal peptide predicted for CAB139 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 34 and 35 218497000665 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218497000666 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 218497000667 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 218497000668 Pfam match to entry PF00496 SBP_bac_5, Bacterial extracellular solute-binding proteins, family 5 , score -23.3, E-value 1.6e-13 218497000669 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 218497000670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 218497000671 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 218497000672 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218497000673 dimer interface [polypeptide binding]; other site 218497000674 conserved gate region; other site 218497000675 ABC-ATPase subunit interface; other site 218497000676 5 probable transmembrane helices predicted for CAB141 by TMHMM2.0 at aa 13-35, 265-287, 294-316, 418-440 and 460-479 218497000677 PS00017 ATP/GTP-binding site motif A (P-loop). 218497000678 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component , score 35.6, E-value 7.5e-08 218497000679 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 218497000680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218497000681 dimer interface [polypeptide binding]; other site 218497000682 conserved gate region; other site 218497000683 putative PBP binding loops; other site 218497000684 ABC-ATPase subunit interface; other site 218497000685 Signal peptide predicted for CAB142 by SignalP 2.0 HMM (Signal peptide probabilty 0.943) with cleavage site probability 0.773 between residues 42 and 43 218497000686 8 probable transmembrane helices predicted for CAB142 by TMHMM2.0 at aa 72-94, 101-123, 377-399, 411-433, 438-460, 489-511 and 545-567 218497000687 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component , score 19.5, E-value 0.00073 218497000688 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 218497000689 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 218497000690 DNA binding site [nucleotide binding] 218497000691 active site 218497000692 Pfam match to entry PF01035 Methyltransf_1, 6-O-methylguanine DNA methyltransferase, DNA binding domain , score 46.2, E-value 4.6e-11 218497000693 PS00374 Methylated-DNA--protein-cysteine methyltransferase active site. 218497000694 Predicted helix-turn-helix motif with score 1302.000, SD 3.62 at aa 114-135, sequence HTYGDIAQATDTHPRTVGAVCK 218497000695 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 218497000696 Signal peptide predicted for CAB144 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.467 between residues 23 and 24 218497000697 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218497000698 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 218497000699 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 218497000700 putative tRNA-binding site [nucleotide binding]; other site 218497000701 B3/4 domain; Region: B3_4; pfam03483 218497000702 tRNA synthetase B5 domain; Region: B5; smart00874 218497000703 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 218497000704 dimer interface [polypeptide binding]; other site 218497000705 motif 1; other site 218497000706 motif 3; other site 218497000707 motif 2; other site 218497000708 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 218497000709 Pfam match to entry PF03147 FDX-ACB, Ferredoxin-fold anticodon binding domain , score 117.0, E-value 2.4e-32 218497000710 Pfam match to entry PF03484 B5, tRNA synthetase B5 domain , score 65.4, E-value 8e-17 218497000711 Pfam match to entry PF03483 B3_4, B3/4 domain , score 150.2, E-value 2.3e-42 218497000712 Pfam match to entry PF01588 tRNA_bind, tRNA binding domain , score 116.4, E-value 3.5e-32 218497000713 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 218497000714 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 218497000715 Signal peptide predicted for CAB146 by SignalP 2.0 HMM (Signal peptide probabilty 0.871) with cleavage site probability 0.569 between residues 34 and 35 218497000716 Pfam match to entry PF01476 LysM, LysM domain , score 67.1, E-value 2.5e-17 218497000717 hypothetical protein; Provisional; Region: PRK14381 218497000718 Pfam match to entry PF01809 DUF37, Domain of unknown function DUF37 , score 128.3, E-value 9.1e-36 218497000719 Uncharacterized conserved protein [Function unknown]; Region: COG1723 218497000720 Pfam match to entry PF02582 DUF155, Uncharacterized ACR, YagE family COG1723 , score 440.6, E-value 9e-130 218497000721 Signal peptide predicted for CAB149 by SignalP 2.0 HMM (Signal peptide probabilty 0.739) with cleavage site probability 0.575 between residues 23 and 24 218497000722 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218497000723 Recombination protein O N terminal; Region: RecO_N; pfam11967 218497000724 DNA repair protein RecO; Region: reco; TIGR00613 218497000725 Recombination protein O C terminal; Region: RecO_C; pfam02565 218497000726 Pfam match to entry PF02565 RecO, Recombination protein O , score 211.2, E-value 1e-60 218497000727 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 218497000728 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 218497000729 30S subunit binding site; other site 218497000730 Response regulator receiver domain; Region: Response_reg; pfam00072 218497000731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218497000732 active site 218497000733 phosphorylation site [posttranslational modification] 218497000734 intermolecular recognition site; other site 218497000735 dimerization interface [polypeptide binding]; other site 218497000736 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218497000737 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 218497000738 Walker A motif; other site 218497000739 ATP binding site [chemical binding]; other site 218497000740 Walker B motif; other site 218497000741 arginine finger; other site 218497000742 PS00688 Sigma-54 interaction domain C-terminal part signature. 218497000743 Pfam match to entry PF00158 Sigma54_activat, Sigma-54 interaction domain , score 423.3, E-value 1.5e-124 218497000744 Pfam match to entry PF00072 response_reg, Response regulator receiver domain , score 116.2, E-value 4.1e-32 218497000745 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 218497000746 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 218497000747 2 probable transmembrane helices predicted for CAB154 by TMHMM2.0 at aa 48-70 and 75-97 218497000748 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 218497000749 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 218497000750 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218497000751 dimer interface [polypeptide binding]; other site 218497000752 phosphorylation site [posttranslational modification] 218497000753 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218497000754 ATP binding site [chemical binding]; other site 218497000755 Mg2+ binding site [ion binding]; other site 218497000756 G-X-G motif; other site 218497000757 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase , score 78.4, E-value 9.7e-21 218497000758 Pfam match to entry PF00512 HisKA, His Kinase A (phosphoacceptor) domain , score 71.6, E-value 1.1e-18 218497000759 Pfam match to entry PF00989 PAS, PAS domain , score 23.1, E-value 5.9e-06 218497000760 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 218497000761 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218497000762 motif II; other site 218497000763 Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase , score 82.8, E-value 4.5e-22 218497000764 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 218497000765 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 218497000766 dimerization interface 3.5A [polypeptide binding]; other site 218497000767 active site 218497000768 Pfam match to entry PF01416 PseudoU_synth_1, tRNA pseudouridine synthase , score 110.8, E-value 1.7e-30 218497000769 Pfam match to entry PF01416 PseudoU_synth_1, tRNA pseudouridine synthase , score 105.6, E-value 6.4e-29 218497000770 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 218497000771 substrate binding site; other site 218497000772 dimer interface; other site 218497000773 Pfam match to entry PF01128 IspD, Uncharacterized protein family UPF0007 , score 102.7, E-value 4.7e-28 218497000774 phosphodiesterase YaeI; Provisional; Region: PRK11340 218497000775 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 218497000776 putative active site [active] 218497000777 putative metal binding site [ion binding]; other site 218497000778 Pfam match to entry PF00149 Metallophos, Calcineurin-like phosphoesterase , score 75.6, E-value 6.9e-20 218497000779 Signal peptide predicted for CAB161 by SignalP 2.0 HMM (Signal peptide probabilty 0.814) with cleavage site probability 0.531 between residues 20 and 21 218497000780 SWIB/MDM2 domain; Region: SWIB; pfam02201 218497000781 Pfam match to entry PF02201 SWIB, BAF60b domain of the SWIB complex , score 135.2, E-value 7.8e-38 218497000782 peptide chain release factor 2; Validated; Region: prfB; PRK00578 218497000783 This domain is found in peptide chain release factors; Region: PCRF; smart00937 218497000784 RF-1 domain; Region: RF-1; pfam00472 218497000785 PF-2 carries a uga in-frame termination codon after leu-23 which is suppressed providing a mechanism for the protein to regulate its own production 218497000786 Pfam match to entry PF03462 PCRF, PCRF domain , score 190.7, E-value 1.5e-54 218497000787 Pfam match to entry PF00472 RF-1, Peptidyl-tRNA hydrolase domain , score 244.8, E-value 7.7e-71 218497000788 PS00745 Prokaryotic-type class I peptide chain release factors signature. 218497000789 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 218497000790 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218497000791 Coenzyme A binding pocket [chemical binding]; other site 218497000792 Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family , score 74.6, E-value 1.3e-19 218497000793 Similar to Chlamydia pneumoniae hypothetical protein cpn0574 or cp0175 SWALL:Q9Z7X9 (EMBL:AE001642) (184 aa) fasta scores: E(): 4.2e-39, 60% id in 185 aa. No other database matches. Possible pseudogene arising from two frameshift mutations.;conserved hypothetical protein (pseudogene) 218497000794 DNA-binding regulatory protein, YebC/PmpR family; Region: TIGR01033 218497000795 Pfam match to entry PF01709 DUF28, Domain of unknown function DUF28 , score 260.4, E-value 1.6e-75 218497000796 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 218497000797 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 218497000798 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 218497000799 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 218497000800 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 218497000801 hinge; other site 218497000802 active site 218497000803 Pfam match to entry PF00275 EPSP_syntase, EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) , score 457.5, E-value 7.3e-135 218497000804 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 218497000805 arginine-tRNA ligase; Region: PLN02286 218497000806 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 218497000807 active site 218497000808 HIGH motif; other site 218497000809 KMSK motif region; other site 218497000810 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 218497000811 tRNA binding surface [nucleotide binding]; other site 218497000812 anticodon binding site; other site 218497000813 Pfam match to entry PF00750 tRNA-synt_1d, tRNA synthetases class I (R) , score 365.0, E-value 5e-107 218497000814 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 218497000815 Pfam match to entry PF03485 N-Arg, Arginyl tRNA synthetase N terminal domain , score 100.4, E-value 2.3e-27 218497000816 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 218497000817 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 218497000818 putative acyl-acceptor binding pocket; other site 218497000819 Pfam match to entry PF01553 Acyltransferase, Acyltransferase , score 118.8, E-value 6.6e-33 218497000820 8 x poly G tract 218497000821 cytidylate kinase; Provisional; Region: cmk; PRK00023 218497000822 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 218497000823 CMP-binding site; other site 218497000824 The sites determining sugar specificity; other site 218497000825 Pfam match to entry PF02224 Cytidylate_kin, Cytidylate kinase , score 265.1, E-value 6.2e-77 218497000826 PS00092 N-6 Adenine-specific DNA methylases signature. 218497000827 PS00017 ATP/GTP-binding site motif A (P-loop). 218497000828 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 218497000829 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 218497000830 Pfam match to entry PF01148 CTP_transf_1, Phosphatidate cytidylyltransferase , score 166.7, E-value 2.5e-47 218497000831 8 probable transmembrane helices predicted for CAB172 by TMHMM2.0 at aa 43-62, 69-91, 96-118, 131-153, 163-185, 205-227, 231-253 and 274-296 218497000832 Signal peptide predicted for CAB172 by SignalP 2.0 HMM (Signal peptide probabilty 0.986) with cleavage site probability 0.526 between residues 44 and 45 218497000833 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14840 218497000834 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 218497000835 catalytic residue [active] 218497000836 putative FPP diphosphate binding site; other site 218497000837 putative FPP binding hydrophobic cleft; other site 218497000838 dimer interface [polypeptide binding]; other site 218497000839 putative IPP diphosphate binding site; other site 218497000840 Pfam match to entry PF01255 UPP_synthetase, undecaprenyl diphosphate synthase , score 291.5, E-value 6.6e-85 218497000841 PS01066 Undecaprenyl pyrophosphate synthetase signature. 218497000842 2 probable transmembrane helices predicted for CAB174 by TMHMM2.0 at aa 38-60 and 67-89 218497000843 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00294 Prenyl group binding site (CAAX box). 218497000844 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK12911 218497000845 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 218497000846 Protein export membrane protein; Region: SecD_SecF; pfam02355 218497000847 12 probable transmembrane helices predicted for CAB175 by TMHMM2.0 at aa 9-31, 912-931, 933-955, 960-982, 1008-1027, 1037-1059, 1091-1113, 1237-1256, 1263-1285, 1295-1314, 1345-1367 and 1372-1394 218497000848 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 218497000849 PS00037 Myb DNA-binding domain repeat signature 1. 218497000850 Pfam match to entry PF02355 SecD_SecF, Protein export membrane protein , score 405.2, E-value 4.1e-119 218497000851 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 218497000852 DHH family; Region: DHH; pfam01368 218497000853 DHHA1 domain; Region: DHHA1; pfam02272 218497000854 Pfam match to entry PF01368 DHH, DHH family , score 182.4, E-value 4.9e-52 218497000855 Pfam match to entry PF02272 DHHA1, DHHA1 domain , score 61.5, E-value 1.2e-15 218497000856 Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677 218497000857 1 probable transmembrane helix predicted for CAB177 by TMHMM2.0 at aa 50-72 218497000858 Helix-turn-helix domain; Region: HTH_17; pfam12728 218497000859 Helix-turn-helix domain; Region: HTH_17; pfam12728 218497000860 Predicted helix-turn-helix motif with score 1177.000, SD 3.20 at aa 30-119, sequence VSITQAAKLHNVTRQAIYVAIKQKKLKASKTTRWEIDLKDLEDYKRNRYSRKKSLYQ GELLFDNDKGCYSVNQVADMLGIPVQKVYYATR 218497000861 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 218497000862 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 218497000863 HIGH motif; other site 218497000864 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 218497000865 active site 218497000866 KMSKS motif; other site 218497000867 Pfam match to entry PF00749 tRNA-synt_1c, tRNA synthetases class I (E and Q), catalytic domain , score 531.7, E-value 3.3e-157 218497000868 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 218497000869 Chlamydia cysteine-rich outer membrane protein 3; Region: Chlam_OMP3; pfam03503 218497000870 Signal peptide predicted for CAB180 by SignalP 2.0 HMM (Signal peptide probabilty 0.682) with cleavage site probability 0.524 between residues 16 and 17 218497000871 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218497000872 Pfam match to entry PF03503 Chlam_OMP3, Chlamydia cysteine-rich outer membrane protein 3 , score 106.2, E-value 4.3e-29 218497000873 Chlamydia cysteine-rich outer membrane protein 6; Region: Chlam_OMP6; pfam03504 218497000874 Domain of unknown function DUF11; Region: DUF11; pfam01345 218497000875 Domain of unknown function DUF11; Region: DUF11; pfam01345 218497000876 Signal peptide predicted for CAB181 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.640 between residues 22 and 23 218497000877 Pfam match to entry PF03504 Chlam_OMP6, Chlamydia cysteine-rich outer membrane protein 6 , score 268.6, E-value 5.3e-78 218497000878 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA); Region: CRPA; pfam05745 218497000879 2 probable transmembrane helices predicted for CAB182 by TMHMM2.0 at aa 61-83 and 90-112 218497000880 Opioid growth factor receptor (OGFr) conserved region; Region: OGFr_N; pfam04664 218497000881 C-terminal peptidase (prc); Region: prc; TIGR00225 218497000882 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 218497000883 protein binding site [polypeptide binding]; other site 218497000884 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 218497000885 Catalytic dyad [active] 218497000886 Pfam match to entry PF00595 PDZ, PDZ domain (Also known as DHR or GLGF) , score 44.8, E-value 1.2e-10 218497000887 Signal peptide predicted for CAB183 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.999 between residues 21 and 22 218497000888 2 probable transmembrane helices predicted for CAB184 by TMHMM2.0 at aa 25-47 and 57-79 218497000889 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 218497000890 Signal peptide predicted for CAB185 by SignalP 2.0 HMM (Signal peptide probabilty 0.970) with cleavage site probability 0.334 between residues 24 and 25 218497000891 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 218497000892 S17 interaction site [polypeptide binding]; other site 218497000893 S8 interaction site; other site 218497000894 16S rRNA interaction site [nucleotide binding]; other site 218497000895 streptomycin interaction site [chemical binding]; other site 218497000896 23S rRNA interaction site [nucleotide binding]; other site 218497000897 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 218497000898 Pfam match to entry PF00164 Ribosomal_S12, Ribosomal protein S12 , score 263.1, E-value 2.4e-76 218497000899 PS00055 Ribosomal protein S12 signature. 218497000900 30S ribosomal protein S7; Validated; Region: PRK05302 218497000901 Pfam match to entry PF00177 Ribosomal_S7, Ribosomal protein S7p/S5e , score 323.3, E-value 1.8e-94 218497000902 PS00052 Ribosomal protein S7 signature. 218497000903 PS00017 ATP/GTP-binding site motif A (P-loop). 218497000904 elongation factor G; Reviewed; Region: PRK12739 218497000905 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 218497000906 G1 box; other site 218497000907 putative GEF interaction site [polypeptide binding]; other site 218497000908 GTP/Mg2+ binding site [chemical binding]; other site 218497000909 Switch I region; other site 218497000910 G2 box; other site 218497000911 G3 box; other site 218497000912 Switch II region; other site 218497000913 G4 box; other site 218497000914 G5 box; other site 218497000915 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 218497000916 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 218497000917 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 218497000918 Pfam match to entry PF00009 GTP_EFTU, Elongation factor Tu GTP binding domain , score 372.7, E-value 2.5e-109 218497000919 PS00017 ATP/GTP-binding site motif A (P-loop). 218497000920 PS00301 GTP-binding elongation factors signature. 218497000921 Pfam match to entry PF03144 GTP_EFTU_D2, Elongation factor Tu domain 2 , score 91.2, E-value 1.4e-24 218497000922 Pfam match to entry PF03764 EFG_IV, Elongation factor G, domain IV , score 230.6, E-value 1.5e-66 218497000923 Pfam match to entry PF00679 EFG_C, Elongation factor G C-terminus , score 147.7, E-value 1.3e-41 218497000924 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 218497000925 Pfam match to entry PF00338 Ribosomal_S10, Ribosomal protein S10p/S20e , score 199.5, E-value 3.4e-57 218497000926 PS00361 Ribosomal protein S10 signature. 218497000927 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 218497000928 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 218497000929 FAD binding pocket [chemical binding]; other site 218497000930 conserved FAD binding motif [chemical binding]; other site 218497000931 phosphate binding motif [ion binding]; other site 218497000932 beta-alpha-beta structure motif; other site 218497000933 NAD binding pocket [chemical binding]; other site 218497000934 Pfam match to entry PF00667 FAD_binding_1, FAD binding domain , score -1.7, E-value 1.2e-07 218497000935 Pfam match to entry PF00175 NAD_binding_1, Oxidoreductase NAD-binding domain , score 59.3, E-value 5.5e-15 218497000936 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 218497000937 homotrimer interaction site [polypeptide binding]; other site 218497000938 zinc binding site [ion binding]; other site 218497000939 CDP-binding sites; other site 218497000940 Pfam match to entry PF02542 YgbB, YgbB family , score 272.2, E-value 4.4e-79 218497000941 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 218497000942 Pfam match to entry PF00829 Ribosomal_L21p, Ribosomal prokaryotic L21 protein , score 138.9, E-value 5.9e-39 218497000943 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 218497000944 Pfam match to entry PF01016 Ribosomal_L27, Ribosomal L27 protein , score 144.4, E-value 1.3e-40 218497000945 GTPase CgtA; Reviewed; Region: obgE; PRK12299 218497000946 GTP1/OBG; Region: GTP1_OBG; pfam01018 218497000947 Obg GTPase; Region: Obg; cd01898 218497000948 G1 box; other site 218497000949 GTP/Mg2+ binding site [chemical binding]; other site 218497000950 Switch I region; other site 218497000951 G2 box; other site 218497000952 G3 box; other site 218497000953 Switch II region; other site 218497000954 G4 box; other site 218497000955 G5 box; other site 218497000956 Pfam match to entry PF01018 GTP1_OBG, GTP1/OBG family , score 282.5, E-value 3.6e-82 218497000957 PS00017 ATP/GTP-binding site motif A (P-loop). 218497000958 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 218497000959 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 218497000960 dimer interface [polypeptide binding]; other site 218497000961 putative PBP binding regions; other site 218497000962 ABC-ATPase subunit interface; other site 218497000963 Pfam match to entry PF00950 ABC-3, ABC 3 transport family , score 172.9, E-value 3.5e-49 218497000964 7 probable transmembrane helices predicted for CAB195 by TMHMM2.0 at aa 39-61, 71-90, 99-121, 141-163, 183-205, 225-247 and 254-271 218497000965 Signal peptide predicted for CAB195 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.428 between residues 28 and 29 218497000966 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 218497000967 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 218497000968 Pfam match to entry PF00005 ABC_tran, ABC transporter , score 160.1, E-value 2.5e-45 218497000969 PS00211 ABC transporters family signature. 218497000970 PS00017 ATP/GTP-binding site motif A (P-loop). 218497000971 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 218497000972 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 218497000973 putative metal binding residues [ion binding]; other site 218497000974 Pfam match to entry PF01297 SBP_bac_9, Periplasmic solute binding protein family , score 321.0, E-value 8.7e-94 218497000975 Signal peptide predicted for CAB197 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.988 between residues 19 and 20 218497000976 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 218497000977 thiamine phosphate binding site [chemical binding]; other site 218497000978 active site 218497000979 pyrophosphate binding site [ion binding]; other site 218497000980 Pfam match to entry PF02581 TMP-TENI, Thiamine monophosphate synthase/TENI , score 150.0, E-value 2.6e-42 218497000981 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 218497000982 substrate binding site [chemical binding]; other site 218497000983 multimerization interface [polypeptide binding]; other site 218497000984 ATP binding site [chemical binding]; other site 218497000985 Pfam match to entry PF02110 HK, Hydroxyethylthiazole kinase , score 230.9, E-value 1.2e-66 218497000986 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 218497000987 Autotransporter beta-domain; Region: Autotransporter; pfam03797 218497000988 PS00017 ATP/GTP-binding site motif A (P-loop). 218497000989 Pfam match to entry PF02415 DUF145, Chlamydia protein of unknown function , score -87.1, E-value 4.4e-06 218497000990 Pfam match to entry PF02415 DUF145, Chlamydia protein of unknown function , score 26.3, E-value 1.1e-07 218497000991 Signal peptide predicted for CAB200 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.995 between residues 21 and 22 218497000992 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 218497000993 Autotransporter beta-domain; Region: Autotransporter; pfam03797 218497000994 Pfam match to entry PF03797 Autotransporter, Autotransporter beta-domain , score -6.7, E-value 0.00059 218497000995 Pfam match to entry PF02415 DUF145, Chlamydia protein of unknown function , score 30.3, E-value 9.8e-11 218497000996 Signal peptide predicted for CAB201 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.536 between residues 23 and 24 218497000997 YtxH-like protein; Region: YtxH; pfam12732 218497000998 1 probable transmembrane helix predicted for CAB202 by TMHMM2.0 at aa 21-43 218497000999 Signal peptide predicted for CAB202 by SignalP 2.0 HMM (Signal peptide probabilty 0.970) with cleavage site probability 0.413 between residues 40 and 41 218497001000 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 218497001001 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 218497001002 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 218497001003 Pfam match to entry PF01235 Na_Ala_symp, Sodium:alanine symporter family , score 18.7, E-value 4.6e-13 218497001004 11 probable transmembrane helices predicted for CAB204 by TMHMM2.0 at aa 15-33, 69-91, 101-123, 150-172, 182-199, 211-230, 240-262, 302-324, 351-372, 379-401 and 406-428 218497001005 PS01186 EGF-like domain signature 2. 218497001006 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 218497001007 lipoprotein signal peptidase; Provisional; Region: PRK14787 218497001008 Pfam match to entry PF01252 Peptidase_A8, Signal peptidase (SPase) II , score 44.0, E-value 5.8e-13 218497001009 3 probable transmembrane helices predicted for CAB205 by TMHMM2.0 at aa 44-63, 70-92 and 107-129 218497001010 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 218497001011 Pfam match to entry PF01258 zf_dskA_traR, Prokaryotic dksA/traR C4-type zinc finger , score 33.4, E-value 3.4e-07 218497001012 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327 218497001013 ATP cone domain; Region: ATP-cone; pfam03477 218497001014 Pfam match to entry PF03477 ATP-cone, ATP cone domain , score 108.7, E-value 7.3e-30 218497001015 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 218497001016 Lumazine binding domain; Region: Lum_binding; pfam00677 218497001017 Lumazine binding domain; Region: Lum_binding; pfam00677 218497001018 Pfam match to entry PF00677 Lum_binding, Lumazine binding domain , score 90.2, E-value 2.6e-24 218497001019 Pfam match to entry PF00677 Lum_binding, Lumazine binding domain , score 103.0, E-value 3.7e-28 218497001020 PS00693 Riboflavin synthase alpha chain family signature. 218497001021 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 218497001022 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218497001023 S-adenosylmethionine binding site [chemical binding]; other site 218497001024 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 218497001025 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 218497001026 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 218497001027 Pfam match to entry PF00588 SpoU_methylase, SpoU rRNA Methylase , score 93.9, E-value 2.1e-25 218497001028 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 218497001029 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 218497001030 Pfam match to entry PF02606 LpxK, Tetraacyldisaccharide-1-P 4'-kinase , score 501.1, E-value 5.5e-148 218497001031 1 probable transmembrane helix predicted for CAB211 by TMHMM2.0 at aa 24-46 218497001032 PS00136 Serine proteases, subtilase, aspartic acid active site. 218497001033 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 218497001034 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 218497001035 Pfam match to entry PF00375 SDF, Sodium:dicarboxylate symporter family , score 388.4, E-value 4.5e-114 218497001036 8 probable transmembrane helices predicted for CAB212 by TMHMM2.0 at aa 7-21, 36-58, 71-93, 135-157, 177-199, 214-233, 312-334 and 344-366 218497001037 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 218497001038 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 218497001039 E3 interaction surface; other site 218497001040 lipoyl attachment site [posttranslational modification]; other site 218497001041 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 218497001042 Pfam match to entry PF00364 biotin_lipoyl, Biotin-requiring enzyme , score 77.5, E-value 1.8e-20 218497001043 PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 218497001044 Pfam match to entry PF02817 e3_binding, e3 binding domain , score 48.4, E-value 1e-11 218497001045 Pfam match to entry PF00198 2-oxoacid_dh, 2-oxo acid dehydrogenases acyltransferase (catalytic domain) , score 368.1, E-value 6e-108 218497001046 KpsF/GutQ family protein; Region: kpsF; TIGR00393 218497001047 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 218497001048 putative active site [active] 218497001049 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 218497001050 Pfam match to entry PF01380 SIS, SIS domain , score 91.5, E-value 1.1e-24 218497001051 Pfam match to entry PF00571 CBS, CBS domain , score 47.0, E-value 2.8e-11 218497001052 Pfam match to entry PF00571 CBS, CBS domain , score 29.0, E-value 7e-06 218497001053 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 218497001054 Putative zinc ribbon domain; Region: DUF164; pfam02591 218497001055 Pfam match to entry PF02591 DUF164, Uncharacterized ACR, COG1579 , score 376.6, E-value 1.6e-110 218497001056 PS00190 Cytochrome c family heme-binding site signature. 218497001057 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 218497001058 2 probable transmembrane helices predicted for CAB217 by TMHMM2.0 at aa 37-59 and 63-85 218497001059 2 probable transmembrane helices predicted for CAB218 by TMHMM2.0 at aa 32-54 and 58-80 218497001060 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 218497001061 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 218497001062 active site 218497001063 Pfam match to entry PF02602 HEM4, Uroporphyrinogen-III synthase HemD , score 96.5, E-value 3.3e-26 218497001064 serine hydroxymethyltransferase; Provisional; Region: PRK13580 218497001065 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 218497001066 dimer interface [polypeptide binding]; other site 218497001067 active site 218497001068 glycine-pyridoxal phosphate binding site [chemical binding]; other site 218497001069 folate binding site [chemical binding]; other site 218497001070 Pfam match to entry PF00464 SHMT, Serine hydroxymethyltransferase , score 450.3, E-value 1.1e-132 218497001071 PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. 218497001072 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 218497001073 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 218497001074 oligomer interface [polypeptide binding]; other site 218497001075 active site residues [active] 218497001076 Pfam match to entry PF00574 CLP_protease, Clp protease , score 207.3, E-value 1.5e-59 218497001077 PS00382 Endopeptidase Clp histidine active site. 218497001078 diaminopimelate epimerase; Region: DapF; TIGR00652 218497001079 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 218497001080 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 218497001081 Pfam match to entry PF01678 DAP_epimerase, Diaminopimelate epimerase , score 9.4, E-value 7.9e-06 218497001082 Pfam match to entry PF01678 DAP_epimerase, Diaminopimelate epimerase , score 57.3, E-value 2.2e-14 218497001083 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 218497001084 Pfam match to entry PF03682 UPF0158, Uncharacterised protein family (UPF0158) , score 373.8, E-value 1.2e-109 218497001085 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 218497001086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218497001087 S-adenosylmethionine binding site [chemical binding]; other site 218497001088 Pfam match to entry PF01209 Ubie_methyltran, ubiE/COQ5 methyltransferase , score 79.0, E-value 6.5e-21 218497001089 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 218497001090 Pfam match to entry PF02621 DUF178, Uncharacterized ACR, COG1427 , score 337.2, E-value 1.2e-98 218497001091 hypothetical protein; Provisional; Region: PRK05926 218497001092 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218497001093 FeS/SAM binding site; other site 218497001094 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 218497001095 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 218497001096 anti sigma factor interaction site; other site 218497001097 regulatory phosphorylation site [posttranslational modification]; other site 218497001098 Pfam match to entry PF01740 STAS, STAS domain , score 107.3, E-value 1.9e-29 218497001099 FOG: CBS domain [General function prediction only]; Region: COG0517 218497001100 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 218497001101 Transporter associated domain; Region: CorC_HlyC; smart01091 218497001102 Pfam match to entry PF03471 CorC_HlyC, Transporter associated domain , score 89.3, E-value 5.2e-24 218497001103 Pfam match to entry PF00571 CBS, CBS domain , score 30.2, E-value 3.1e-06 218497001104 Pfam match to entry PF00571 CBS, CBS domain , score 37.4, E-value 2.1e-08 218497001105 4 probable transmembrane helices predicted for CAB230 by TMHMM2.0 at aa 2-19, 39-61, 73-95 and 100-119 218497001106 Signal peptide predicted for CAB230 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.604 between residues 20 and 21 218497001107 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 218497001108 Pfam match to entry PF02130 UPF0054, Uncharacterized protein family UPF0054 , score -5.2, E-value 0.00016 218497001109 Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137 218497001110 Uncharacterized conserved protein [Function unknown]; Region: COG2928 218497001111 Signal peptide predicted for CAB234 by SignalP 2.0 HMM (Signal peptide probabilty 0.993) with cleavage site probability 0.408 between residues 23 and 24 218497001112 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 218497001113 active site 218497001114 DNA binding site [nucleotide binding] 218497001115 Pfam match to entry PF02245 Pur_DNA_glyco, Methylpurine-DNA glycosylase (MPG) , score 292.7, E-value 2.9e-85 218497001116 Exoribonuclease R [Transcription]; Region: VacB; COG0557 218497001117 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 218497001118 RNA binding site [nucleotide binding]; other site 218497001119 RNB domain; Region: RNB; pfam00773 218497001120 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 218497001121 RNA binding site [nucleotide binding]; other site 218497001122 PS01175 Ribonuclease II family signature. 218497001123 Pfam match to entry PF00773 RNB, RNB-like protein , score 519.0, E-value 2.2e-153 218497001124 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 218497001125 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 218497001126 nucleotide binding site [chemical binding]; other site 218497001127 NEF interaction site [polypeptide binding]; other site 218497001128 SBD interface [polypeptide binding]; other site 218497001129 Pfam match to entry PF00012 HSP70, Hsp70 protein , score 1350.0, E-value 0 218497001130 PS01036 Heat shock hsp70 proteins family signature 3. 218497001131 PS00329 Heat shock hsp70 proteins family signature 2. 218497001132 PS00297 Heat shock hsp70 proteins family signature 1. 218497001133 GrpE; Region: GrpE; pfam01025 218497001134 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 218497001135 dimer interface [polypeptide binding]; other site 218497001136 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 218497001137 Pfam match to entry PF01025 GrpE, GrpE , score 228.6, E-value 6e-66 218497001138 PS01071 grpE protein signature. 218497001139 Transcriptional regulator of heat shock gene [Transcription]; Region: HrcA; COG1420 218497001140 Pfam match to entry PF01628 HrcA, HrcA protein C terminal domain , score 211.1, E-value 1.1e-60 218497001141 prolyl-tRNA synthetase; Provisional; Region: PRK09194 218497001142 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 218497001143 dimer interface [polypeptide binding]; other site 218497001144 motif 1; other site 218497001145 active site 218497001146 motif 2; other site 218497001147 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 218497001148 putative deacylase active site [active] 218497001149 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 218497001150 active site 218497001151 motif 3; other site 218497001152 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 218497001153 anticodon binding site; other site 218497001154 Pfam match to entry PF03129 HGTP_anticodon, Anticodon binding domain , score 79.5, E-value 4.4e-21 218497001155 PS00017 ATP/GTP-binding site motif A (P-loop). 218497001156 Pfam match to entry PF00587 tRNA-synt_2b, tRNA synthetase class II core domain (G, H, P, S and T) , score 170.7, E-value 1.5e-48 218497001157 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 218497001158 Signal peptide predicted for CAB242 by SignalP 2.0 HMM (Signal peptide probabilty 0.951) with cleavage site probability 0.746 between residues 34 and 35 218497001159 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218497001160 hypothetical protein; Validated; Region: PRK00647 218497001161 Pfam match to entry PF02594 DUF167, Uncharacterized ACR, YggU family COG1872 , score 122.8, E-value 4.2e-34 218497001162 ABC transporter substrate binding protein; Region: ABC_sub_bind; cl17301 218497001163 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 218497001164 Signal peptide predicted for CAB244 by SignalP 2.0 HMM (Signal peptide probabilty 0.975) with cleavage site probability 0.813 between residues 25 and 26 218497001165 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 218497001166 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218497001167 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218497001168 homodimer interface [polypeptide binding]; other site 218497001169 catalytic residue [active] 218497001170 Pfam match to entry PF00155 aminotran_1_2, Aminotransferase class I and II , score 48.8, E-value 8.1e-12 218497001171 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 218497001172 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 218497001173 Signal peptide predicted for CAB247 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.841 between residues 31 and 32 218497001174 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 218497001175 Uncharacterized protein family (UPF0160); Region: UPF0160; cl01749 218497001176 Pfam match to entry PF03690 UPF0160, Uncharacterised protein family (UPF0160) , score 541.0, E-value 5.2e-160 218497001177 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 218497001178 nucleotide binding site/active site [active] 218497001179 Pfam match to entry PF01230 HIT, HIT family , score 166.9, E-value 2.2e-47 218497001180 PS00892 HIT family signature. 218497001181 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 218497001182 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 218497001183 Na binding site [ion binding]; other site 218497001184 13 probable transmembrane helices predicted for CAB252 by TMHMM2.0 at aa 6-28, 49-71, 76-98, 129-148, 163-182, 189-208, 218-240, 261-283, 298-320, 341-363, 368-390, 397-419 and 423-445 218497001185 Pfam match to entry PF00474 SSF, Sodium:solute symporter family , score -56.1, E-value 4.9e-07 218497001186 1 probable transmembrane helix predicted for CAB253 by TMHMM2.0 at aa 7-24 218497001187 Similar to many proposed to be involved in aromatic amino acid biosynthesis including: Bacillus subtilis AroA aroA SWALL:AROG_BACSU (SWALL:P39912) (358 aa) fasta scores: E(): 3.4e-34, 42.56% id in 242 aa, and to Chlamydia pneumoniae deoxyheptonate aldolase arog or cpn0484 or cp0270 SWALL:Q9Z867 (EMBL:AE001633) (285 aa) fasta scores: E(): 1.6e-76, 74.62% id in 268 aa. Note, lacks an appropriate translational start site.; aldolase (pseudogene) 218497001188 Pfam match to entry PF00793 DAHP_synth_1, DAHP synthetase I family , score 348.2, E-value 5.7e-102 218497001189 Peptidase C65 Otubain; Region: Peptidase_C65; pfam10275 218497001190 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218497001191 1 probable transmembrane helix predicted for CAB255 by TMHMM2.0 at aa 34-56 218497001192 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218497001193 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 218497001194 substrate binding pocket [chemical binding]; other site 218497001195 membrane-bound complex binding site; other site 218497001196 hinge residues; other site 218497001197 Signal peptide predicted for CAB256 by SignalP 2.0 HMM (Signal peptide probabilty 0.925) with cleavage site probability 0.619 between residues 27 and 28 218497001198 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218497001199 Pfam match to entry PF00497 SBP_bac_3, Bacterial extracellular solute-binding proteins, family 3 , score 137.4, E-value 1.7e-38 218497001200 2 probable transmembrane helices predicted for CAB257 by TMHMM2.0 at aa 107-129 and 139-161 218497001201 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 218497001202 putative hydrolase; Provisional; Region: PRK02113 218497001203 Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily , score 13.5, E-value 0.00017 218497001204 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 218497001205 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 218497001206 HflX GTPase family; Region: HflX; cd01878 218497001207 G1 box; other site 218497001208 GTP/Mg2+ binding site [chemical binding]; other site 218497001209 Switch I region; other site 218497001210 G2 box; other site 218497001211 G3 box; other site 218497001212 Switch II region; other site 218497001213 G4 box; other site 218497001214 G5 box; other site 218497001215 PS00017 ATP/GTP-binding site motif A (P-loop). 218497001216 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 218497001217 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 218497001218 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218497001219 FeS/SAM binding site; other site 218497001220 Pfam match to entry PF00919 UPF0004, Uncharacterized protein family UPF0004 , score 36.8, E-value 7.4e-10 218497001221 PS01278 Uncharacterized protein family UPF0004 signature. 218497001222 glycogen branching enzyme; Provisional; Region: PRK05402 218497001223 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 218497001224 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 218497001225 active site 218497001226 catalytic site [active] 218497001227 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 218497001228 Pfam match to entry PF02922 isoamylase_N, Isoamylase N-terminal domain , score 104.3, E-value 1.5e-28 218497001229 Pfam match to entry PF00128 alpha-amylase, Alpha amylase, catalytic domain , score -39.6, E-value 2e-08 218497001230 10 probable transmembrane helices predicted for CAB263 by TMHMM2.0 at aa 54-76, 86-108, 127-149, 159-181, 210-232, 242-264, 353-375, 390-409, 478-500 and 504-526 218497001231 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 218497001232 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 218497001233 Autotransporter beta-domain; Region: Autotransporter; smart00869 218497001234 Pfam match to entry PF03797 Autotransporter, Autotransporter beta-domain , score 34.8, E-value 1.3e-07 218497001235 Pfam match to entry PF02415 DUF145, Chlamydia protein of unknown function , score -43.0, E-value 7.9e-08 218497001236 Signal peptide predicted for CAB265 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.686 between residues 25 and 26 218497001237 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218497001238 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 218497001239 Autotransporter beta-domain; Region: Autotransporter; smart00869 218497001240 Pfam match to entry PF02415 DUF145, Chlamydia protein of unknown function , score -39.5, E-value 5.7e-08 218497001241 8 x poly G tract 218497001242 Autotransporter beta-domain; Region: Autotransporter; smart00869 218497001243 Signal peptide predicted for CAB267 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 1.000 between residues 24 and 25 218497001244 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 218497001245 Autotransporter beta-domain; Region: Autotransporter; pfam03797 218497001246 Pfam match to entry PF02415 DUF145, Chlamydia protein of unknown function , score -55.8, E-value 2.5e-07 218497001247 PS00017 ATP/GTP-binding site motif A (P-loop). 218497001248 Signal peptide predicted for CAB268 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.689 between residues 24 and 25 218497001249 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 218497001250 Autotransporter beta-domain; Region: Autotransporter; pfam03797 218497001251 Pfam match to entry PF03797 Autotransporter, Autotransporter beta-domain , score -1.3, E-value 0.0003 218497001252 Pfam match to entry PF02415 DUF145, Chlamydia protein of unknown function , score 245.5, E-value 4.8e-71 218497001253 Signal peptide predicted for CAB269 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.972 between residues 24 and 25 218497001254 Similar to Chlamydophila abortus 98 kDa outer membrane protein SWALL:P71135 (EMBL:U72499) (926 aa) fasta scores: E(): 1.9e-47, 29.68% id in 923 aa, and to Chlamydia pneumoniae probable outer membrane protein Pmp7 precursor or omp12 or cpn0445 or cp0308 SWALL:PMP7_CHLPN (SWALL:Q9Z898) (936 aa) fasta scores: E(): 4.9e-42, 29.54% id in 819 aa. Note this CDS carries multiple frameshift mutations.;polymorphic outer membrane protein (pseudogene) 218497001255 homopolymeric tract 218497001256 PS00389 ATP synthase delta (OSCP) subunit signature. 218497001257 Pfam match to entry PF02415 DUF145, Chlamydia protein of unknown function , score -47.4, E-value 1.2e-07 218497001258 Signal peptide predicted for CAB272 by SignalP 2.0 HMM (Signal peptide probabilty 0.975) with cleavage site probability 0.478 between residues 25 and 26 218497001259 Similar to Chlamydophila abortus 98 kDa outer membrane protein SWALL:P71135 (EMBL:U72499) (926 aa) fasta scores: E(): 2.5e-47, 29.97% id in 1001 aa, and to Chlamydia psittaci pomp90b precursor SWALL:P77792 (EMBL:U65943) (839 aa) fasta scores: E(): 1.2e-42, 31.89% id in 975 aa Note this CDS carries multiple frameshift mutations;polymorphic outer membrane protein (pseudogene) 218497001260 Pfam match to entry PF02415 DUF145, Chlamydia protein of unknown function , score 59.6, E-value 4.9e-17 218497001261 Pfam match to entry PF02415 DUF145, Chlamydia protein of unknown function , score 47.9, E-value 9.2e-14 218497001262 Signal peptide predicted for CAB276 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.595 between residues 22 and 23 218497001263 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 218497001264 Autotransporter beta-domain; Region: Autotransporter; pfam03797 218497001265 Pfam match to entry PF02415 DUF145, Chlamydia protein of unknown function , score 242.0, E-value 5.6e-70 218497001266 Signal peptide predicted for CAB277 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.579 between residues 23 and 24 218497001267 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 218497001268 Autotransporter beta-domain; Region: Autotransporter; pfam03797 218497001269 Pfam match to entry PF03797 Autotransporter, Autotransporter beta-domain , score 2.5, E-value 0.00019 218497001270 Pfam match to entry PF02415 DUF145, Chlamydia protein of unknown function , score 190.0, E-value 2.5e-54 218497001271 Signal peptide predicted for CAB278 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.939 between residues 29 and 30 218497001272 Similar to Chlamydia psittaci pomp90b precursor SWALL:P77792 (EMBL:U65943) (839 aa) fasta scores: E(): 0, 98.45% id in 841 aa, and to Chlamydophila abortus pomp91a SWALL:P71132 (EMBL:U65942) (847 aa) fasta scores: E(): 0, 77.97% id in 849 aa. Note the frameshift mutation of this CDS occurs in a homopolymeric tract, consequently the expression of its exported protein product is thought to be phase variable;polymorphic outer membrane protein (pseudogene) 218497001273 Pfam match to entry PF02415 DUF145, Chlamydia protein of unknown function , score 671.6, E-value 2.6e-199 218497001274 17 x poly G tract and the site of the frameshift. This is a candidate site for phase variation of the expression of this gene and its complete product 218497001275 Signal peptide predicted for CAB280 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.956 between residues 23 and 24 218497001276 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 218497001277 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 218497001278 Autotransporter beta-domain; Region: Autotransporter; pfam03797 218497001279 Pfam match to entry PF02415 DUF145, Chlamydia protein of unknown function , score 697.4, E-value 4.5e-207 218497001280 10 x poly G tract 218497001281 Signal peptide predicted for CAB281 by SignalP 2.0 HMM (Signal peptide probabilty 0.970) with cleavage site probability 0.969 between residues 22 and 23 218497001282 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 218497001283 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 218497001284 Autotransporter beta-domain; Region: Autotransporter; pfam03797 218497001285 Pfam match to entry PF03797 Autotransporter, Autotransporter beta-domain , score 6.5, E-value 0.00011 218497001286 Pfam match to entry PF02415 DUF145, Chlamydia protein of unknown function , score 15.2, E-value 0.00014 218497001287 Pfam match to entry PF02415 DUF145, Chlamydia protein of unknown function , score 719.0, E-value 1.4e-213 218497001288 Signal peptide predicted for CAB282 by SignalP 2.0 HMM (Signal peptide probabilty 0.991) with cleavage site probability 0.977 between residues 30 and 31 218497001289 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 218497001290 Autotransporter beta-domain; Region: Autotransporter; pfam03797 218497001291 Pfam match to entry PF02415 DUF145, Chlamydia protein of unknown function , score 17.3, E-value 3.6e-05 218497001292 Pfam match to entry PF02415 DUF145, Chlamydia protein of unknown function , score 69.2, E-value 5.7e-18 218497001293 Signal peptide predicted for CAB283 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.984 between residues 34 and 35 218497001294 Domain of unknown function (DUF378); Region: DUF378; pfam04070 218497001295 2 probable transmembrane helices predicted for CAB284 by TMHMM2.0 at aa 5-27 and 42-64 218497001296 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 218497001297 Pfam match to entry PF02686 Glu-tRNAGln, Glu-tRNAGln amidotransferase C subunit , score 57.1, E-value 2.4e-14 218497001298 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 218497001299 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 218497001300 Pfam match to entry PF01425 Amidase, Amidase , score 629.5, E-value 1.3e-186 218497001301 PS00571 Amidases signature. 218497001302 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 218497001303 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 218497001304 GatB domain; Region: GatB_Yqey; pfam02637 218497001305 Pfam match to entry PF02934 GatB_N, PET112 family, N terminal region , score 469.3, E-value 2e-138 218497001306 PS01234 PET112 family signature. 218497001307 Pfam match to entry PF01162 GatB, PET112 family, C terminal region , score 114.6, E-value 1.2e-31 218497001308 Predicted helix-turn-helix motif with score 1128.000, SD 3.03 at aa 335-356, sequence AHFFELAAQECKNYRALSNWLT 218497001309 Pfam match to entry PF02637 DUF186, GatB/Yqey domain , score 212.3, E-value 4.6e-61 218497001310 4 probable transmembrane helices predicted for CAB288 by TMHMM2.0 at aa 75-97, 102-124, 139-161 and 168-190 218497001311 3 probable transmembrane helices predicted for CAB289 by TMHMM2.0 at aa 41-63, 89-111 and 118-137 218497001312 ribonuclease HIII; Provisional; Region: PRK00996 218497001313 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 218497001314 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 218497001315 RNA/DNA hybrid binding site [nucleotide binding]; other site 218497001316 active site 218497001317 Pfam match to entry PF01351 RNase_HII, Ribonuclease HII , score 35.6, E-value 8.8e-11 218497001318 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 218497001319 Helix-turn-helix domain; Region: HTH_25; pfam13413 218497001320 1 probable transmembrane helix predicted for CAB292 by TMHMM2.0 at aa 103-125 218497001321 PS00697 ATP-dependent DNA ligase AMP-binding site. 218497001322 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 218497001323 Signal peptide predicted for CAB296 by SignalP 2.0 HMM (Signal peptide probabilty 0.961) with cleavage site probability 0.569 between residues 30 and 31 218497001324 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 218497001325 Signal peptide predicted for CAB297 by SignalP 2.0 HMM (Signal peptide probabilty 0.638) with cleavage site probability 0.231 between residues 30 and 31 218497001326 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 218497001327 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 218497001328 catalytic residues [active] 218497001329 Pfam match to entry PF03190 DUF255, Protein of unknown function, DUF255 , score 167.2, E-value 1.8e-47 218497001330 PS00589 PTS HPR component serine phosphorylation site signature. 218497001331 Signal peptide predicted for CAB299 by SignalP 2.0 HMM (Signal peptide probabilty 0.975) with cleavage site probability 0.855 between residues 23 and 24 218497001332 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 218497001333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218497001334 S-adenosylmethionine binding site [chemical binding]; other site 218497001335 Pfam match to entry PF00398 RrnaAD, Ribosomal RNA adenine dimethylase , score 194.1, E-value 1.4e-55 218497001336 PS01131 Ribosomal RNA adenine dimethylases signature. 218497001337 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 218497001338 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 218497001339 TPP-binding site; other site 218497001340 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 218497001341 PYR/PP interface [polypeptide binding]; other site 218497001342 dimer interface [polypeptide binding]; other site 218497001343 TPP binding site [chemical binding]; other site 218497001344 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 218497001345 Pfam match to entry PF02780 transketolase_C, Transketolase, C-terminal domain , score 117.7, E-value 1.5e-32 218497001346 Pfam match to entry PF02779 transket_pyr, Transketolase, pyridine binding domain , score 172.1, E-value 6e-49 218497001347 PS00801 Transketolase signature 1. 218497001348 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 218497001349 Pfam match to entry PF02609 Exonuc_VII_S, Exonuclease VII small subunit , score 40.5, E-value 2.5e-09 218497001350 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 218497001351 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 218497001352 generic binding surface II; other site 218497001353 generic binding surface I; other site 218497001354 Pfam match to entry PF02601 Exonuc_VII_L, Exonuclease VII, large subunit , score 308.9, E-value 3.9e-90 218497001355 Pfam match to entry PF01336 tRNA_anti, OB-fold nucleic acid binding domain , score 26.6, E-value 3.8e-05 218497001356 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 218497001357 triosephosphate isomerase; Provisional; Region: PRK14565 218497001358 substrate binding site [chemical binding]; other site 218497001359 dimer interface [polypeptide binding]; other site 218497001360 catalytic triad [active] 218497001361 Pfam match to entry PF00121 TIM, Triosephosphate isomerase , score 310.0, E-value 1.8e-90 218497001362 PS00171 Triosephosphate isomerase active site. 218497001363 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 218497001364 Signal peptide predicted for CAB306 by SignalP 2.0 HMM (Signal peptide probabilty 0.933) with cleavage site probability 0.704 between residues 38 and 39 218497001365 Pfam match to entry PF03840 SecG, Preprotein translocase SecG subunit , score 88.5, E-value 8.9e-24 218497001366 probable transmembrane helices predicted for CAB306 by TMHMM2.0 at aa 57-79 218497001367 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 218497001368 active site 218497001369 catalytic residues [active] 218497001370 metal binding site [ion binding]; metal-binding site 218497001371 Pfam match to entry PF01327 Pep_deformylase, Polypeptide deformylase , score 177.3, E-value 1.6e-50 218497001372 PS00436 Peroxidases active site signature. 218497001373 Signal peptide predicted for CAB308 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.623 between residues 22 and 23 218497001374 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218497001375 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 218497001376 Pfam match to entry PF03130 HEAT_PBS, PBS lyase HEAT-like repeat , score 20.2, E-value 0.0032 218497001377 Signal peptide predicted for CAB309 by SignalP 2.0 HMM (Signal peptide probabilty 0.923) with cleavage site probability 0.750 between residues 22 and 23 218497001378 Maf-like protein; Region: Maf; pfam02545 218497001379 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 218497001380 active site 218497001381 dimer interface [polypeptide binding]; other site 218497001382 Pfam match to entry PF02545 Maf, Maf-like protein , score 294.5, E-value 8.7e-86 218497001383 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 218497001384 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 218497001385 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218497001386 Walker A/P-loop; other site 218497001387 ATP binding site [chemical binding]; other site 218497001388 Q-loop/lid; other site 218497001389 ABC transporter signature motif; other site 218497001390 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 218497001391 Walker B; other site 218497001392 D-loop; other site 218497001393 H-loop/switch region; other site 218497001394 ABC transporter; Region: ABC_tran_2; pfam12848 218497001395 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 218497001396 Pfam match to entry PF00005 ABC_tran, ABC transporter , score 120.3, E-value 2.4e-33 218497001397 PS00017 ATP/GTP-binding site motif A (P-loop). 218497001398 Pfam match to entry PF00005 ABC_tran, ABC transporter , score 109.7, E-value 3.7e-30 218497001399 PS00017 ATP/GTP-binding site motif A (P-loop). 218497001400 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 218497001401 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 218497001402 active site 218497001403 Int/Topo IB signature motif; other site 218497001404 Pfam match to entry PF00589 Phage_integrase, Phage integrase , score 171.6, E-value 8.4e-49 218497001405 Pfam match to entry PF02899 Phage_integr_N, Phage integrase, N-terminal SAM-like domain , score 45.9, E-value 6e-11 218497001406 ribonuclease Z; Region: RNase_Z; TIGR02651 218497001407 Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily , score 18.0, E-value 2.1e-05 218497001408 IncA protein; Region: IncA; pfam04156 218497001409 probable transmembrane helices predicted for CAB314 by TMHMM2.0 at aa 69-91 218497001410 Signal peptide predicted for CAB314 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.980 between residues 64 and 65 218497001411 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 218497001412 Found in ATP-dependent protease La (LON); Region: LON; smart00464 218497001413 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218497001414 Walker A motif; other site 218497001415 ATP binding site [chemical binding]; other site 218497001416 Walker B motif; other site 218497001417 arginine finger; other site 218497001418 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 218497001419 PS01046 ATP-dependent serine proteases, lon family, serine active site. 218497001420 Pfam match to entry PF00004 AAA, ATPase associated with various cellular activities (AAA) , score 167.8, E-value 1.2e-47 218497001421 PS00017 ATP/GTP-binding site motif A (P-loop). 218497001422 Pfam match to entry PF02190 LON, ATP-dependent protease La (LON) domain , score 96.7, E-value 3e-26 218497001423 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 218497001424 Glycoprotease family; Region: Peptidase_M22; pfam00814 218497001425 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 218497001426 Pfam match to entry PF01165 Ribosomal_S21, Ribosomal protein S21 , score 44.4, E-value 1.7e-10 218497001427 chaperone protein DnaJ; Provisional; Region: PRK14284 218497001428 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 218497001429 HSP70 interaction site [polypeptide binding]; other site 218497001430 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 218497001431 Zn binding sites [ion binding]; other site 218497001432 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 218497001433 dimer interface [polypeptide binding]; other site 218497001434 Pfam match to entry PF00226 DnaJ, DnaJ domain , score 156.8, E-value 2.4e-44 218497001435 PS00636 Nt-dnaJ domain signature. 218497001436 Pfam match to entry PF00684 DnaJ_CXXCXGXG, DnaJ central domain (4 repeats) , score 88.2, E-value 1.1e-23 218497001437 PS00637 CXXCXGXG dnaJ domain signature. 218497001438 Pfam match to entry PF01556 DnaJ_C, DnaJ C terminal region , score 201.2, E-value 1e-57 218497001439 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 218497001440 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 218497001441 tetramer interface [polypeptide binding]; other site 218497001442 TPP-binding site [chemical binding]; other site 218497001443 heterodimer interface [polypeptide binding]; other site 218497001444 phosphorylation loop region [posttranslational modification] 218497001445 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 218497001446 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 218497001447 alpha subunit interface [polypeptide binding]; other site 218497001448 TPP binding site [chemical binding]; other site 218497001449 heterodimer interface [polypeptide binding]; other site 218497001450 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 218497001451 Pfam match to entry PF00676 E1_dehydrog, Dehydrogenase E1 component , score 116.4, E-value 3.5e-32 218497001452 Pfam match to entry PF02779 transket_pyr, Transketolase, pyridine binding domain , score 246.1, E-value 3.2e-71 218497001453 Pfam match to entry PF02780 transketolase_C, Transketolase, C-terminal domain , score 183.2, E-value 2.8e-52 218497001454 Similar to several Chlamydophila proteins of unknown function e.g. Chlamydophila caviae hypothetical protein Cca00325 SWALL:Q823T0 (EMBL:AE016995) (345 aa) fasta scores: E(): 2.5e-62, 51.45% id in 344 aa and to Chlamydia pneumoniae hypothetical protein Cp0742 SWALL:Q9K1Z7 (EMBL:AE002233) (425 aa) fasta scores: E(): 4.9e-21, 31.12% id in 241 aa. Note this CDS appears to have a frameshift mutation following codon 231; membrane protein (pseudogene) 218497001455 2 probable transmembrane helices predicted for CAB321 by TMHMM2.0 at aa 35-57 and 61-75 218497001456 Competence protein; Region: Competence; pfam03772 218497001457 Pfam match to entry PF03772 Competence, Competence protein , score 66.0, E-value 5.3e-17 218497001458 5 probable transmembrane helices predicted for CAB322 by TMHMM2.0 at aa 232-254, 261-283, 324-346, 358-380 and 395-417 218497001459 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 218497001460 dimerization domain swap beta strand [polypeptide binding]; other site 218497001461 regulatory protein interface [polypeptide binding]; other site 218497001462 active site 218497001463 regulatory phosphorylation site [posttranslational modification]; other site 218497001464 Pfam match to entry PF00381 PTS-HPr, PTS HPr component phosphorylation site , score 43.4, E-value 3.3e-10 218497001465 PS00589 PTS HPR component serine phosphorylation site signature. 218497001466 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 218497001467 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 218497001468 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 218497001469 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 218497001470 Pfam match to entry PF00391 PEP-utilizers, PEP-utilizing enzyme, mobile domain , score 73.3, E-value 3.4e-19 218497001471 PS00370 PEP-utilizing enzymes phosphorylation site signature. 218497001472 Pfam match to entry PF02896 PEP-utilizers_C, PEP-utilizing enzyme, TIM barrel domain , score 138.1, E-value 1e-38 218497001473 PS00742 PEP-utilizing enzymes signature 2. 218497001474 hypothetical protein; Validated; Region: PRK00153 218497001475 Pfam match to entry PF02575 DUF149, Uncharacterized BCR, YbaB family COG0718 , score 110.6, E-value 2e-30 218497001476 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06305 218497001477 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218497001478 Walker A motif; other site 218497001479 ATP binding site [chemical binding]; other site 218497001480 Walker B motif; other site 218497001481 arginine finger; other site 218497001482 Pfam match to entry PF00004 AAA, ATPase associated with various cellular activities (AAA) , score 27.5, E-value 5.4e-07 218497001483 PS00017 ATP/GTP-binding site motif A (P-loop). 218497001484 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 218497001485 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 218497001486 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 218497001487 Zn2+ binding site [ion binding]; other site 218497001488 Mg2+ binding site [ion binding]; other site 218497001489 7 probable transmembrane helices predicted for CAB328 by TMHMM2.0 at aa 28-50, 260-282, 295-317, 337-359, 366-385, 395-417 and 430-452 218497001490 Pfam match to entry PF01966 HD, HD domain , score 70.8, E-value 1.9e-18 218497001491 3 probable transmembrane helices predicted for CAB329 by TMHMM2.0 at aa 47-69, 95-117 and 121-143 218497001492 2 probable transmembrane helices predicted for CAB330 by TMHMM2.0 at aa 48-65 and 110-132 218497001493 2 probable transmembrane helices predicted for CAB331 by TMHMM2.0 at aa 45-67 and 98-120 218497001494 porphobilinogen deaminase; Provisional; Region: PRK01066 218497001495 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 218497001496 domain interfaces; other site 218497001497 active site 218497001498 Pfam match to entry PF01379 Porphobil_deam, Porphobilinogen deaminase, dipyromethane cofactor binding domain , score 55.1, E-value 1e-17 218497001499 DNA repair protein RadA; Provisional; Region: PRK11823 218497001500 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 218497001501 Walker A motif/ATP binding site; other site 218497001502 ATP binding site [chemical binding]; other site 218497001503 Walker B motif; other site 218497001504 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 218497001505 PS00017 ATP/GTP-binding site motif A (P-loop). 218497001506 ribonuclease III; Reviewed; Region: rnc; PRK00102 218497001507 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 218497001508 dimerization interface [polypeptide binding]; other site 218497001509 active site 218497001510 metal binding site [ion binding]; metal-binding site 218497001511 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 218497001512 Pfam match to entry PF00035 dsrm, Double-stranded RNA binding motif , score 70.6, E-value 2.1e-18 218497001513 Pfam match to entry PF00636 Ribonuclease_3, RNase3 domain , score 151.0, E-value 1.4e-42 218497001514 PS00517 Ribonuclease III family signature. 218497001515 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 218497001516 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 218497001517 active site 218497001518 substrate binding site [chemical binding]; other site 218497001519 metal binding site [ion binding]; metal-binding site 218497001520 Pfam match to entry PF02878 PGM_PMM_I, Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I , score 187.5, E-value 1.4e-53 218497001521 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 218497001522 Pfam match to entry PF02879 PGM_PMM_II, Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II , score 0.5, E-value 0.00036 218497001523 Pfam match to entry PF02880 PGM_PMM_III, Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III , score 10.7, E-value 0.0003 218497001524 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 218497001525 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 218497001526 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 218497001527 Pfam match to entry PF00081 sodfe, Iron/manganese superoxide dismutases, alpha-hairpin domain , score 160.7, E-value 1.6e-45 218497001528 Pfam match to entry PF02777 sodfe_C, Iron/manganese superoxide dismutases, C-terminal domain , score 177.5, E-value 1.4e-50 218497001529 PS00088 Manganese and iron superoxide dismutases signature. 218497001530 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 218497001531 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 218497001532 PS00190 Cytochrome c family heme-binding site signature. 218497001533 Pfam match to entry PF01039 Carboxyl_trans, Carboxyl transferase domain , score 49.4, E-value 7e-14 218497001534 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 218497001535 trimer interface [polypeptide binding]; other site 218497001536 active site 218497001537 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 218497001538 active site 218497001539 phosphorylation site [posttranslational modification] 218497001540 Pfam match to entry PF00359 PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 , score 44.4, E-value 1.5e-10 218497001541 PS00372 PTS EIIA domains phosphorylation site signature 2. 218497001542 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 218497001543 DNA binding residues [nucleotide binding] 218497001544 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 218497001545 active site 218497001546 phosphorylation site [posttranslational modification] 218497001547 Predicted helix-turn-helix motif with score 2001.000, SD 6.00 at aa 3-24, sequence LKLEELASLLDISENTVRRWLD 218497001548 Pfam match to entry PF00359 PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 , score -2.4, E-value 1.1e-06 218497001549 PS00372 PTS EIIA domains phosphorylation site signature 2. 218497001550 Signal peptide predicted for CAB341 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.852 between residues 28 and 29 218497001551 1 probable transmembrane helix predicted for CAB341 by TMHMM2.0 at aa 423-445 218497001552 4 probable transmembrane helices predicted for CAB342 by TMHMM2.0 at aa 36-58, 63-85, 242-264 and 269-291 218497001553 2 probable transmembrane helices predicted for CAB343 by TMHMM2.0 at aa 30-52 and 59-81 218497001554 2 probable transmembrane helices predicted for CAB344 by TMHMM2.0 at aa 66-88 and 98-120 218497001555 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 218497001556 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 218497001557 Ligand Binding Site [chemical binding]; other site 218497001558 Signal peptide predicted for CAB345 by SignalP 2.0 HMM (Signal peptide probabilty 0.685) with cleavage site probability 0.672 between residues 19 and 20 218497001559 Pfam match to entry PF03054 tRNA_Me_trans, tRNA methyl transferase , score 712.2, E-value 1.5e-211 218497001560 PS00070 Aldehyde dehydrogenases cysteine active site. 218497001561 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 218497001562 Clp amino terminal domain; Region: Clp_N; pfam02861 218497001563 Clp amino terminal domain; Region: Clp_N; pfam02861 218497001564 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218497001565 Walker A motif; other site 218497001566 ATP binding site [chemical binding]; other site 218497001567 Walker B motif; other site 218497001568 arginine finger; other site 218497001569 UvrB/uvrC motif; Region: UVR; pfam02151 218497001570 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218497001571 Walker A motif; other site 218497001572 ATP binding site [chemical binding]; other site 218497001573 Walker B motif; other site 218497001574 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 218497001575 Pfam match to entry PF00004 AAA, ATPase associated with various cellular activities (AAA) , score 4.7, E-value 3.7e-05 218497001576 PS00017 ATP/GTP-binding site motif A (P-loop). 218497001577 Pfam match to entry PF02151 UVR, UvrB/uvrC motif , score 38.5, E-value 1e-08 218497001578 Pfam match to entry PF00004 AAA, ATPase associated with various cellular activities (AAA) , score 45.6, E-value 7.2e-11 218497001579 PS00870 Chaperonins clpA/B signature 1. 218497001580 PS00017 ATP/GTP-binding site motif A (P-loop). 218497001581 Pfam match to entry PF02861 Clp_N, Clp amino terminal domain , score 71.2, E-value 1.4e-18 218497001582 Pfam match to entry PF02861 Clp_N, Clp amino terminal domain , score 83.3, E-value 3.3e-22 218497001583 PS00307 Legume lectins beta-chain signature. 218497001584 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 218497001585 Pfam match to entry PF03099 BPL_LipA_LipB, Biotin/lipoate A/B protein ligase , score 71.1, E-value 1.6e-18 218497001586 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 218497001587 PLD-like domain; Region: PLDc_2; pfam13091 218497001588 putative active site [active] 218497001589 catalytic site [active] 218497001590 Signal peptide predicted for CAB348 by SignalP 2.0 HMM (Signal peptide probabilty 0.936) with cleavage site probability 0.443 between residues 24 and 25 218497001591 Pfam match to entry PF00614 PLDc, Phospholipase D. Active site motif , score 9.1, E-value 0.24 218497001592 PS00214 Cytosolic fatty-acid binding proteins signature. 218497001593 Pfam match to entry PF00614 PLDc, Phospholipase D. Active site motif , score 21.6, E-value 0.0012 218497001594 Chlamydial GcvH-like protein upstream region protein; Region: near_not_gcvH; TIGR03076 218497001595 1 probable transmembrane helix predicted for CAB349 by TMHMM2.0 at aa 13-35 218497001596 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 218497001597 lipoyl attachment site [posttranslational modification]; other site 218497001598 Pfam match to entry PF01597 GCV_H, Glycine cleavage H-protein , score 43.0, E-value 1.8e-10 218497001599 2 probable transmembrane helices predicted for CAB351 by TMHMM2.0 at aa 27-49 and 54-76 218497001600 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK01061 218497001601 PS00017 ATP/GTP-binding site motif A (P-loop). 218497001602 Pfam match to entry PF02508 Rnf-Nqr, Rnf-Nqr subunit, membrane protein , score 326.7, E-value 1.8e-95 218497001603 6 probable transmembrane helices predicted for CAB352 by TMHMM2.0 at aa 15-37, 44-66, 89-111, 118-140, 150-172 and 185-207 218497001604 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD [Energy production and conversion]; Region: NqrD; COG1347 218497001605 5 probable transmembrane helices predicted for CAB353 by TMHMM2.0 at aa 72-94, 101-118, 128-147, 154-173 and 183-205 218497001606 Pfam match to entry PF02508 Rnf-Nqr, Rnf-Nqr subunit, membrane protein , score 342.1, E-value 3.9e-100 218497001607 Signal peptide predicted for CAB353 by SignalP 2.0 HMM (Signal peptide probabilty 0.890) with cleavage site probability 0.510 between residues 33 and 34 218497001608 FMN-binding domain; Region: FMN_bind; cl01081 218497001609 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 218497001610 Signal peptide predicted for CAB354 by SignalP 2.0 HMM (Signal peptide probabilty 0.979) with cleavage site probability 0.399 between residues 31 and 32 218497001611 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK01024 218497001612 Pfam match to entry PF03116 NQR2_RnfD_RnfE, NQR2, RnfD, RnfE family , score 993.5, E-value 3.2e-296 218497001613 8 probable transmembrane helices predicted for CAB355 by TMHMM2.0 at aa 57-79, 120-142, 155-177, 356-378, 385-407, 417-439, 452-469 and 473-495 218497001614 Similar to Chlamydia pneumoniae hypothetical protein ct277 SWALL:Q9Z8B7 (EMBL:AE001625) (192 aa) fasta scores: E(): 7.4e-16, 48.88% id in 90 aa. This CDS carries a frameshift mutation following codon 97 which may occur within a 7xT homopolymeric tract leaving open the possibility that the gene product of this CDS is subject to phase variation. Only significant database matches are to Chlamydiaceae proteins.;conserved hypothetical protein (pseudogene) 218497001615 Site of frameshift mutation in CAB356 and homopolymeric tract 7x T residues 218497001616 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 218497001617 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 218497001618 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 218497001619 DnaA N-terminal domain; Region: DnaA_N; pfam11638 218497001620 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218497001621 Walker A motif; other site 218497001622 ATP binding site [chemical binding]; other site 218497001623 Walker B motif; other site 218497001624 arginine finger; other site 218497001625 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 218497001626 DnaA box-binding interface [nucleotide binding]; other site 218497001627 Pfam match to entry PF00308 bac_dnaA, Bacterial dnaA protein , score 491.4, E-value 4.6e-145 218497001628 PS00017 ATP/GTP-binding site motif A (P-loop). 218497001629 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 218497001630 TPR motif; other site 218497001631 binding surface 218497001632 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 218497001633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218497001634 S-adenosylmethionine binding site [chemical binding]; other site 218497001635 Pfam match to entry PF01795 Methyltransf_5, MraW methylase , score 507.9, E-value 5.1e-150 218497001636 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 218497001637 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 218497001638 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 218497001639 1 probable transmembrane helix predicted for CAB362 by TMHMM2.0 at aa 7-26 218497001640 Pfam match to entry PF03717 PBP_dimer, Penicillin-binding Protein dimerisation domain , score 84.7, E-value 1.2e-22 218497001641 Pfam match to entry PF00905 Transpeptidase, Penicillin binding protein transpeptidase domain , score 151.5, E-value 9.3e-43 218497001642 Similar to Chlamydophila caviae hypothetical protein cca00375 SWALL:Q823N3 (EMBL:AE016995) (147 aa) fasta scores: E(): 3.2e-32, 68.42% id in 133 aa, and to Chlamydia pneumoniae hypothetical protein cpn0221 cpn0221 or cpj0221 or cp0544 or cpb0225 SWALL:Q9Z8W3 (EMBL:AE001608) (136 aa) fasta scores: E(): 1.4e-08, 36.6% id in 112 aa. Note this CDS carries a premature stop codon following codon 53 and appears to have lost the very N-terminal region.;membrane protein (remnant) 218497001643 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 218497001644 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 218497001645 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 218497001646 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 218497001647 Pfam match to entry PF01225 Mur_ligase, Mur ligase, catalytic domain , score 215.0, E-value 7.4e-62 218497001648 Pfam match to entry PF02875 Mur_ligase_C, Mur ligase, glutamate ligase domain , score 99.2, E-value 5.3e-27 218497001649 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 218497001650 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 218497001651 active site 218497001652 metal binding site [ion binding]; metal-binding site 218497001653 Signal peptide predicted for CAB364 by SignalP 2.0 HMM (Signal peptide probabilty 0.988) with cleavage site probability 0.700 between residues 34 and 35 218497001654 Pfam match to entry PF01520 Amidase_3, N-acetylmuramoyl-L-alanine amidase , score 186.6, E-value 2.5e-53 218497001655 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 218497001656 IHF - DNA interface [nucleotide binding]; other site 218497001657 IHF dimer interface [polypeptide binding]; other site 218497001658 Pfam match to entry PF00216 Bac_DNA_binding, Bacterial DNA-binding protein , score 121.0, E-value 1.4e-33 218497001659 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 218497001660 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; pfam03255 218497001661 Pfam match to entry PF03255 ACCA, Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit , score 317.5, E-value 1e-92 218497001662 PS00070 Aldehyde dehydrogenases cysteine active site. 218497001663 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 218497001664 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 218497001665 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218497001666 Walker A/P-loop; other site 218497001667 ATP binding site [chemical binding]; other site 218497001668 Q-loop/lid; other site 218497001669 ABC transporter signature motif; other site 218497001670 Walker B; other site 218497001671 D-loop; other site 218497001672 H-loop/switch region; other site 218497001673 Signal peptide predicted for CAB368 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.971 between residues 34 and 35 218497001674 Pfam match to entry PF00664 ABC_membrane, ABC transporter transmembrane region , score 75.4, E-value 7.9e-20 218497001675 4 probable transmembrane helices predicted for CAB368 by TMHMM2.0 at aa 120-142, 199-221, 225-244 and 312-334 218497001676 Pfam match to entry PF00005 ABC_tran, ABC transporter , score 193.7, E-value 1.9e-55 218497001677 PS00017 ATP/GTP-binding site motif A (P-loop). 218497001678 PS00211 ABC transporters family signature. 218497001679 nucleosidase; Provisional; Region: PRK05634 218497001680 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 218497001681 Pfam match to entry PF02642 DUF191, Uncharacterized ACR, COG2107 , score 433.9, E-value 9.4e-128 218497001682 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 218497001683 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 218497001684 active site 218497001685 catalytic site [active] 218497001686 substrate binding site [chemical binding]; other site 218497001687 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 218497001688 Pfam match to entry PF00929 Exonuclease, Exonuclease , score 157.0, E-value 2.1e-44 218497001689 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218497001690 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 218497001691 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 218497001692 1 probable transmembrane helix predicted for CAB373 by TMHMM2.0 at aa 27-49 218497001693 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 218497001694 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 218497001695 active site 218497001696 motif I; other site 218497001697 motif II; other site 218497001698 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06300 218497001699 enoyl-[acyl-carrier-protein] reductase; Region: PLN02730 218497001700 NAD(P) binding site [chemical binding]; other site 218497001701 active site 218497001702 Pfam match to entry PF00106 adh_short, short chain dehydrogenase , score -7.0, E-value 4.7e-07 218497001703 Similar to Chlamydophila caviae conserved hypothetical protein cca00390 SWALL:Q823L9 (EMBL:AE016995) (898 aa) fasta scores: E(): 2.2e-91, 46.97% id in 645 aa. This CDS carries a frameshift following codon 544 and premature stop codons. Note rich in the aa Leu and Ser;conserved hypothetical protein (pseudogene) 218497001704 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 218497001705 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 218497001706 RNA binding surface [nucleotide binding]; other site 218497001707 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 218497001708 active site 218497001709 Pfam match to entry PF00849 PseudoU_synth_2, RNA pseudouridylate synthase , score 154.7, E-value 1e-43 218497001710 PS01129 Rlu family of pseudouridine synthase signature. 218497001711 Pfam match to entry PF01479 S4, S4 domain , score 28.4, E-value 1.1e-05 218497001712 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 218497001713 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 218497001714 minor groove reading motif; other site 218497001715 helix-hairpin-helix signature motif; other site 218497001716 substrate binding pocket [chemical binding]; other site 218497001717 active site 218497001718 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 218497001719 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 218497001720 DNA binding and oxoG recognition site [nucleotide binding] 218497001721 Pfam match to entry PF00730 HhH-GPD, HhH-GPD superfamily base excision DNA repair protein , score 203.2, E-value 2.6e-58 218497001722 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 218497001723 homodimer interface [polypeptide binding]; other site 218497001724 metal binding site [ion binding]; metal-binding site 218497001725 CAAX protease self-immunity; Region: Abi; pfam02517 218497001726 Pfam match to entry PF02517 Abi, CAAX amino terminal protease , score 106.6, E-value 3e-29 218497001727 6 probable transmembrane helices predicted for CAB382 by TMHMM2.0 at aa 5-24, 36-55, 70-92, 113-135, 160-182 and 194-211 218497001728 Signal peptide predicted for CAB382 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.436 between residues 24 and 25 218497001729 Signal peptide predicted for CAB383 by SignalP 2.0 HMM (Signal peptide probabilty 0.920) with cleavage site probability 0.337 between residues 51 and 52 218497001730 Similar to several Chlamydiaceae proteins including: Chlamydophila caviae hypothetical protein cca00645 SWALL:Q822N6 (EMBL:AE016996) (132 aa) fasta scores: E(): 3.2, 26.08% id in 138 aa, and to Chlamydia pneumoniae ct058 hypothetical protein cpn0370 or cpj0370 or cp0387 or cpb0382 SWALL:Q9Z8H3 (EMBL:AE001621) (371 aa) fasta scores: E(): 9.2, 23.74% id in 139 aa. Note this CDS appears to have a frameshift mutation following codon 102 which occurs in a homopolymeric tract(9x G). This leaves open the possibility that the expression of its protein product may be subject to phase variation.; conserved membrane protein (pseudogene) 218497001731 9 x poly G tract 218497001732 Similar to Chlamydophila caviae hypothetical protein cca00397 SWALL:Q823L3 (EMBL:AE016995) (121 aa) fasta scores: E(): 5.1e-17, 53.6% id in 125 aa. Note the premature stop codon within the sequence.; conserved membrane protein (pseudogene) 218497001733 1 probable transmembrane helix predicted for CAB384 by TMHMM2.0 at aa 38-60 218497001734 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 218497001735 2 probable transmembrane helices predicted for CAB385 by TMHMM2.0 at aa 2-21 and 25-47 218497001736 Signal peptide predicted for CAB385 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.546 between residues 21 and 22 218497001737 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 218497001738 active site 218497001739 Pfam match to entry PF00481 PP2C, Protein phosphatase 2C , score -22.9, E-value 6.6e-06 218497001740 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 218497001741 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 218497001742 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 218497001743 catalytic residue [active] 218497001744 Pfam match to entry PF00266 aminotran_5, Aminotransferase class-V , score 109.9, E-value 3.2e-30 218497001745 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 218497001746 Domain of unknown function DUF21; Region: DUF21; pfam01595 218497001747 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 218497001748 Transporter associated domain; Region: CorC_HlyC; smart01091 218497001749 Pfam match to entry PF03471 CorC_HlyC, Transporter associated domain , score 63.1, E-value 3.8e-16 218497001750 Pfam match to entry PF00571 CBS, CBS domain , score 21.2, E-value 0.0016 218497001751 Pfam match to entry PF00571 CBS, CBS domain , score 13.2, E-value 0.07 218497001752 Pfam match to entry PF01595 DUF21, Domain of unknown function DUF21 , score 30.1, E-value 2.3e-07 218497001753 4 probable transmembrane helices predicted for CAB388 by TMHMM2.0 at aa 10-32, 53-75, 95-114 and 121-143 218497001754 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 218497001755 Domain of unknown function DUF21; Region: DUF21; pfam01595 218497001756 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 218497001757 Transporter associated domain; Region: CorC_HlyC; smart01091 218497001758 Pfam match to entry PF03471 CorC_HlyC, Transporter associated domain , score 85.2, E-value 8.4e-23 218497001759 Pfam match to entry PF00571 CBS, CBS domain , score 20.6, E-value 0.0024 218497001760 Pfam match to entry PF00571 CBS, CBS domain , score 31.7, E-value 1.1e-06 218497001761 Pfam match to entry PF01595 DUF21, Domain of unknown function DUF21 , score 75.5, E-value 7.1e-20 218497001762 3 probable transmembrane helices predicted for CAB389 by TMHMM2.0 at aa 5-27, 60-82 and 89-111 218497001763 Signal peptide predicted for CAB389 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.848 between residues 23 and 24 218497001764 E2 (early) protein, N terminal; Region: PPV_E2_N; pfam00508 218497001765 1 probable transmembrane helix predicted for CAB390 by TMHMM2.0 at aa 13-35 218497001766 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 218497001767 trimer interface [polypeptide binding]; other site 218497001768 active site 218497001769 Pfam match to entry PF00692 dUTPase, dUTPase , score -7.5, E-value 0.0011 218497001770 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 218497001771 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218497001772 Walker A motif; other site 218497001773 ATP binding site [chemical binding]; other site 218497001774 Walker B motif; other site 218497001775 arginine finger; other site 218497001776 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 218497001777 Pfam match to entry PF00004 AAA, ATPase associated with various cellular activities (AAA) , score 111.0, E-value 1.5e-30 218497001778 PS00017 ATP/GTP-binding site motif A (P-loop). 218497001779 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 218497001780 Signal peptide predicted for CAB393 by SignalP 2.0 HMM (Signal peptide probabilty 0.938) with cleavage site probability 0.571 between residues 19 and 20 218497001781 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 218497001782 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 218497001783 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 218497001784 active site 218497001785 catalytic site [active] 218497001786 Pfam match to entry PF00128 alpha-amylase, Alpha amylase, catalytic domain , score 89.5, E-value 4.4e-24 218497001787 Pfam match to entry PF02922 isoamylase_N, Isoamylase N-terminal domain , score 83.3, E-value 3.2e-22 218497001788 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 218497001789 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 218497001790 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 218497001791 dimer interface [polypeptide binding]; other site 218497001792 ssDNA binding site [nucleotide binding]; other site 218497001793 tetramer (dimer of dimers) interface [polypeptide binding]; other site 218497001794 Pfam match to entry PF00436 SSB, Single-strand binding protein family , score 89.5, E-value 4.4e-24 218497001795 multifunctional aminopeptidase A; Provisional; Region: PRK00913 218497001796 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 218497001797 interface (dimer of trimers) [polypeptide binding]; other site 218497001798 Substrate-binding/catalytic site; other site 218497001799 Zn-binding sites [ion binding]; other site 218497001800 Pfam match to entry PF02789 Peptidase_M17_N, Cytosol aminopeptidase, N-terminal domain , score -5.1, E-value 0.014 218497001801 Pfam match to entry PF00883 Peptidase_M17, Cytosol aminopeptidase, catalytic domain , score 487.1, E-value 8.9e-144 218497001802 Histone H1-like nucleoprotein HC2; Region: HC2; pfam07382 218497001803 hypothetical protein; Provisional; Region: PRK05907 218497001804 Predicted helix-turn-helix motif with score 1086.000, SD 2.89 at aa 41-62, sequence SGKAQEMDALGLTISDLSQWTE 218497001805 Predicted methyltransferases [General function prediction only]; Region: COG0313 218497001806 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 218497001807 putative SAM binding site [chemical binding]; other site 218497001808 homodimer interface [polypeptide binding]; other site 218497001809 Pfam match to entry PF00590 TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases , score -37.8, E-value 0.0027 218497001810 3 probable transmembrane helices predicted for CAB401 by TMHMM2.0 at aa 10-31, 51-73 and 93-115 218497001811 coproporphyrinogen III oxidase; Provisional; Region: PRK06294 218497001812 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218497001813 FeS/SAM binding site; other site 218497001814 HemN C-terminal domain; Region: HemN_C; pfam06969 218497001815 Pfam match to entry PF02473 Coprogen_an_ox, Oxygen-independent Coproporphyrinogen III oxidase , score -61.9, E-value 2.8e-11 218497001816 Protein of unknown function (DUF342); Region: DUF342; pfam03961 218497001817 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 218497001818 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 218497001819 TPP-binding site [chemical binding]; other site 218497001820 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 218497001821 Pfam match to entry PF00676 E1_dehydrog, Dehydrogenase E1 component , score 127.4, E-value 1.7e-35 218497001822 Pfam match to entry PF02779 transket_pyr, Transketolase, pyridine binding domain , score 201.5, E-value 8.6e-58 218497001823 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 218497001824 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 218497001825 E3 interaction surface; other site 218497001826 lipoyl attachment site [posttranslational modification]; other site 218497001827 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 218497001828 Pfam match to entry PF00364 biotin_lipoyl, Biotin-requiring enzyme , score 39.3, E-value 5.8e-09 218497001829 Pfam match to entry PF00198 2-oxoacid_dh, 2-oxo acid dehydrogenases acyltransferase (catalytic domain) , score 423.7, E-value 1.1e-124 218497001830 uncharacterized protein, YfiH family; Region: TIGR00726 218497001831 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 218497001832 Pfam match to entry PF02578 DUF152, Uncharacterized ACR, YfiH family COG1496 , score 281.4, E-value 7.3e-82 218497001833 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 218497001834 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional; Region: PRK02048 218497001835 2 probable transmembrane helices predicted for CAB410 by TMHMM2.0 at aa 49-71 and 76-98 218497001836 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 218497001837 ADP-ribose binding site [chemical binding]; other site 218497001838 2 probable transmembrane helices predicted for CAB411 by TMHMM2.0 at aa 47-69 and 73-95 218497001839 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 218497001840 ADP-ribose binding site [chemical binding]; other site 218497001841 2 probable transmembrane helices predicted for CAB412 by TMHMM2.0 at aa 33-55 and 59-78 218497001842 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 218497001843 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 218497001844 catalytic loop [active] 218497001845 iron binding site [ion binding]; other site 218497001846 Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domain , score 50.9, E-value 1.8e-12 218497001847 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 218497001848 type III secretion system protein; Validated; Region: PRK05910 218497001849 FHIPEP family; Region: FHIPEP; pfam00771 218497001850 7 probable transmembrane helices predicted for CAB414 by TMHMM2.0 at aa 9-26, 30-52, 64-86, 101-123, 191-213, 228-250 and 275-297 218497001851 Pfam match to entry PF00771 FHIPEP, FHIPEP family , score 494.2, E-value 6.4e-146 218497001852 RNA polymerase sigma factor sigma-28; Reviewed; Region: PRK05911 218497001853 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 218497001854 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 218497001855 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 218497001856 DNA binding residues [nucleotide binding] 218497001857 Predicted helix-turn-helix motif with score 1024.000, SD 2.67 at aa 222-148, sequence ASARPALIISLNEERPSLSDGESGVALEERIADERAETGYDIVDKKEFSSFLASAIE SLEEKERKVMALYYYEEL 218497001858 probable transmembrane helices predicted for CAB416 by TMHMM2.0 at aa 57-79 218497001859 Signal peptide predicted for CAB416 by SignalP 2.0 HMM (Signal peptide probabilty 0.990) with cleavage site probability 0.936 between residues 50 and 51 218497001860 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 218497001861 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 218497001862 active site 218497001863 HIGH motif; other site 218497001864 dimer interface [polypeptide binding]; other site 218497001865 KMSKS motif; other site 218497001866 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 218497001867 RNA binding surface [nucleotide binding]; other site 218497001868 Pfam match to entry PF00579 tRNA-synt_1b, tRNA synthetases class I (W and Y) , score 339.8, E-value 2e-99 218497001869 Pfam match to entry PF01479 S4, S4 domain , score 38.0, E-value 1.4e-08 218497001870 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873 218497001871 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 218497001872 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 218497001873 Pfam match to entry PF03446 NAD_binding_2, NAD binding domain of 6-phosphogluconate dehydrogenase , score 400.1, E-value 1.4e-117 218497001874 Pfam match to entry PF00393 6PGD, 6-phosphogluconate dehydrogenase, C-terminal domain , score 505.7, E-value 2.3e-149 218497001875 PS00461 6-phosphogluconate dehydrogenase signature. 218497001876 GTP-binding protein LepA; Provisional; Region: PRK05433 218497001877 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 218497001878 G1 box; other site 218497001879 putative GEF interaction site [polypeptide binding]; other site 218497001880 GTP/Mg2+ binding site [chemical binding]; other site 218497001881 Switch I region; other site 218497001882 G2 box; other site 218497001883 G3 box; other site 218497001884 Switch II region; other site 218497001885 G4 box; other site 218497001886 G5 box; other site 218497001887 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 218497001888 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 218497001889 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 218497001890 Pfam match to entry PF00679 EFG_C, Elongation factor G C-terminus , score 112.5, E-value 5.1e-31 218497001891 Pfam match to entry PF03144 GTP_EFTU_D2, Elongation factor Tu domain 2 , score 72.0, E-value 7.9e-19 218497001892 Pfam match to entry PF00009 GTP_EFTU, Elongation factor Tu GTP binding domain , score 248.6, E-value 5.5e-72 218497001893 PS00017 ATP/GTP-binding site motif A (P-loop). 218497001894 Protein of unknown function (DUF1389); Region: DUF1389; pfam07146 218497001895 2 probable transmembrane helices predicted for CAB420 by TMHMM2.0 at aa 31-53 and 60-82 218497001896 ADP/ATP carrier protein family; Region: AAA; TIGR00769 218497001897 Pfam match to entry PF03219 TLC, TLC ATP/ADP transporter , score 1124.4, E-value 0 218497001898 11 probable transmembrane helices predicted for CAB421 by TMHMM2.0 at aa 27-44, 59-81, 94-116, 149-171, 184-206, 221-243, 285-307, 327-345, 352-374, 384-406 and 462-484 218497001899 PS00430 TonB-dependent receptor proteins signature 1. 218497001900 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 218497001901 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 218497001902 intersubunit interface [polypeptide binding]; other site 218497001903 Signal peptide predicted for CAB423 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.428 between residues 32 and 33 218497001904 Pfam match to entry PF01297 SBP_bac_9, Periplasmic solute binding protein family , score 366.2, E-value 2.2e-107 218497001905 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218497001906 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 218497001907 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 218497001908 Pfam match to entry PF00005 ABC_tran, ABC transporter , score 158.2, E-value 9.1e-45 218497001909 PS00017 ATP/GTP-binding site motif A (P-loop). 218497001910 PS00211 ABC transporters family signature. 218497001911 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 218497001912 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 218497001913 ABC-ATPase subunit interface; other site 218497001914 dimer interface [polypeptide binding]; other site 218497001915 putative PBP binding regions; other site 218497001916 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 218497001917 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 218497001918 Signal peptide predicted for CAB425 by SignalP 2.0 HMM (Signal peptide probabilty 0.828) with cleavage site probability 0.519 between residues 29 and 30 218497001919 Pfam match to entry PF00950 ABC-3, ABC 3 transport family , score 46.5, E-value 1.1e-12 218497001920 6 probable transmembrane helices predicted for CAB425 by TMHMM2.0 at aa 68-90, 102-120, 143-165, 190-212, 232-254 and 266-288 218497001921 Pfam match to entry PF02742 Fe_dep_repr_C, Iron dependent repressor, metal binding and dimerisation domain , score 59.3, E-value 5.5e-15 218497001922 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 218497001923 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 218497001924 ABC-ATPase subunit interface; other site 218497001925 dimer interface [polypeptide binding]; other site 218497001926 putative PBP binding regions; other site 218497001927 Pfam match to entry PF00950 ABC-3, ABC 3 transport family , score 12.6, E-value 4.7e-11 218497001928 9 probable transmembrane helices predicted for CAB426 by TMHMM2.0 at aa 39-61, 66-88, 92-114, 127-144, 167-189, 196-218, 228-250, 255-277 and 281-303 218497001929 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 218497001930 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 218497001931 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 218497001932 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 218497001933 Signal peptide predicted for CAB427 by SignalP 2.0 HMM (Signal peptide probabilty 0.775) with cleavage site probability 0.733 between residues 19 and 20 218497001934 Pfam match to entry PF02670 DXP_reductoisom, 1-deoxy-D-xylulose 5-phosphate reductoisomerase , score 690.7, E-value 4.7e-205 218497001935 PS00017 ATP/GTP-binding site motif A (P-loop). 218497001936 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 218497001937 RIP metalloprotease RseP; Region: TIGR00054 218497001938 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 218497001939 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 218497001940 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 218497001941 putative substrate binding region [chemical binding]; other site 218497001942 Signal peptide predicted for CAB428 by SignalP 2.0 HMM (Signal peptide probabilty 0.939) with cleavage site probability 0.399 between residues 19 and 20 218497001943 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 218497001944 3 probable transmembrane helices predicted for CAB428 by TMHMM2.0 at aa 102-124, 557-579 and 591-613 218497001945 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 218497001946 Putative serine esterase (DUF676); Region: DUF676; pfam05057 218497001947 Signal peptide predicted for CAB429 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.901 between residues 21 and 22 218497001948 recombination protein F; Reviewed; Region: recF; PRK00064 218497001949 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218497001950 Walker A/P-loop; other site 218497001951 ATP binding site [chemical binding]; other site 218497001952 Q-loop/lid; other site 218497001953 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218497001954 ABC transporter signature motif; other site 218497001955 Walker B; other site 218497001956 D-loop; other site 218497001957 H-loop/switch region; other site 218497001958 Predicted helix-turn-helix motif with score 1198.000, SD 3.27 at aa 342-363, sequence QTLSEANRIFSVNQAQISIHSH 218497001959 Pfam match to entry PF02463 SMC_N, RecF/RecN/SMC N terminal domain , score -10.7, E-value 8.4e-07 218497001960 PS00017 ATP/GTP-binding site motif A (P-loop). 218497001961 DNA polymerase III subunit beta; Validated; Region: PRK05643 218497001962 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 218497001963 putative DNA binding surface [nucleotide binding]; other site 218497001964 dimer interface [polypeptide binding]; other site 218497001965 beta-clamp/clamp loader binding surface; other site 218497001966 beta-clamp/translesion DNA polymerase binding surface; other site 218497001967 Pfam match to entry PF02768 DNA_pol3_beta_3, DNA polymerase III beta subunit, C-terminal domain , score 39.2, E-value 6.1e-09 218497001968 Pfam match to entry PF02767 DNA_pol3_beta_2, DNA polymerase III beta subunit, central domain , score 99.3, E-value 4.9e-27 218497001969 Pfam match to entry PF00712 DNA_pol3_beta, DNA polymerase III beta subunit, N-terminal domain , score 67.3, E-value 2.1e-17 218497001970 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 218497001971 SmpB-tmRNA interface; other site 218497001972 Pfam match to entry PF01668 SmpB, SmpB protein , score 111.6, E-value 1e-30 218497001973 PS01317 Protein smpB signature. 218497001974 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 218497001975 ApbE family; Region: ApbE; pfam02424 218497001976 Pfam match to entry PF02424 ApbE, ApbE family , score 388.8, E-value 3.5e-114 218497001977 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218497001978 Signal peptide predicted for CAB433 by SignalP 2.0 HMM (Signal peptide probabilty 0.737) with cleavage site probability 0.520 between residues 19 and 20 218497001979 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14181 218497001980 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 218497001981 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 218497001982 homodimer interface [polypeptide binding]; other site 218497001983 NADP binding site [chemical binding]; other site 218497001984 substrate binding site [chemical binding]; other site 218497001985 Pfam match to entry PF02882 THF_DHG_CYH_C, Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain , score 367.3, E-value 1e-107 218497001986 PS00767 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. 218497001987 Pfam match to entry PF00763 THF_DHG_CYH, Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain , score 202.6, E-value 3.9e-58 218497001988 4 probable transmembrane helices predicted for CAB435 by TMHMM2.0 at aa 13-35, 50-72, 93-115 and 137-159 218497001989 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 218497001990 PLD-like domain; Region: PLDc_2; pfam13091 218497001991 putative active site [active] 218497001992 catalytic site [active] 218497001993 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 218497001994 PLD-like domain; Region: PLDc_2; pfam13091 218497001995 putative active site [active] 218497001996 catalytic site [active] 218497001997 Pfam match to entry PF00614 PLDc, Phospholipase D. Active site motif , score 5.5, E-value 0.78 218497001998 Pfam match to entry PF00614 PLDc, Phospholipase D. Active site motif , score 18.6, E-value 0.0094 218497001999 Signal peptide predicted for CAB439 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.782 between residues 27 and 28 218497002000 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 218497002001 Pfam match to entry PF01977 UPF0096, VdcC family , score 675.7, E-value 1.5e-200 218497002002 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 218497002003 Pfam match to entry PF00830 Ribosomal_L28, Ribosomal L28 family , score 40.5, E-value 2.5e-09 218497002004 PS00017 ATP/GTP-binding site motif A (P-loop). 218497002005 4-alpha-glucanotransferase; Region: Glyco_hydro_77; pfam02446 218497002006 Pfam match to entry PF02446 4A_glucanotrans, 4-alpha-glucanotransferase , score 857.8, E-value 2.3e-255 218497002007 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 218497002008 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 218497002009 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 218497002010 FHIPEP family; Region: FHIPEP; pfam00771 218497002011 Pfam match to entry PF00771 FHIPEP, FHIPEP family , score 1214.0, E-value 0 218497002012 6 probable transmembrane helices predicted for CAB445 by TMHMM2.0 at aa 27-49, 64-86, 119-141, 209-231, 244-266 and 309-331 218497002013 type III secretion system protein; Validated; Region: PRK06298 218497002014 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 218497002015 Pfam match to entry PF01312 Bac_export_2, FlhB HrpN YscU SpaS Family , score 588.4, E-value 2.8e-174 218497002016 5 probable transmembrane helices predicted for CAB446 by TMHMM2.0 at aa 27-49, 93-115, 136-158, 163-180 and 187-206 218497002017 GTP-binding protein YchF; Reviewed; Region: PRK09601 218497002018 YchF GTPase; Region: YchF; cd01900 218497002019 G1 box; other site 218497002020 GTP/Mg2+ binding site [chemical binding]; other site 218497002021 Switch I region; other site 218497002022 G2 box; other site 218497002023 Switch II region; other site 218497002024 G3 box; other site 218497002025 G4 box; other site 218497002026 G5 box; other site 218497002027 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 218497002028 Pfam match to entry PF01018 GTP1_OBG, GTP1/OBG family , score 7.7, E-value 0.029 218497002029 PS00017 ATP/GTP-binding site motif A (P-loop). 218497002030 Pfam match to entry PF01018 GTP1_OBG, GTP1/OBG family , score 6.6, E-value 0.06 218497002031 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 218497002032 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 218497002033 active site 218497002034 Riboflavin kinase; Region: Flavokinase; pfam01687 218497002035 Pfam match to entry PF01687 FAD_Synth, Riboflavin kinase / FAD synthetase , score 101.5, E-value 1.1e-27 218497002036 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00989 218497002037 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 218497002038 RNA binding site [nucleotide binding]; other site 218497002039 active site 218497002040 Pfam match to entry PF01509 TruB_N, TruB family pseudouridylate synthase (N terminal domain) , score 180.5, E-value 1.8e-51 218497002041 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 218497002042 Pfam match to entry PF02033 RBFA, Ribosome-binding factor A , score 40.3, E-value 2.8e-09 218497002043 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 218497002044 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 218497002045 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 218497002046 G1 box; other site 218497002047 putative GEF interaction site [polypeptide binding]; other site 218497002048 GTP/Mg2+ binding site [chemical binding]; other site 218497002049 Switch I region; other site 218497002050 G2 box; other site 218497002051 G3 box; other site 218497002052 Switch II region; other site 218497002053 G4 box; other site 218497002054 G5 box; other site 218497002055 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 218497002056 Translation-initiation factor 2; Region: IF-2; pfam11987 218497002057 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 218497002058 Pfam match to entry PF03144 GTP_EFTU_D2, Elongation factor Tu domain 2 , score 43.5, E-value 3.1e-10 218497002059 PS01176 Initiation factor 2 signature. 218497002060 Pfam match to entry PF03144 GTP_EFTU_D2, Elongation factor Tu domain 2 , score 52.9, E-value 4.6e-13 218497002061 Pfam match to entry PF00009 GTP_EFTU, Elongation factor Tu GTP binding domain , score 173.3, E-value 2.6e-49 218497002062 PS00017 ATP/GTP-binding site motif A (P-loop). 218497002063 transcription termination factor NusA; Region: NusA; TIGR01953 218497002064 NusA N-terminal domain; Region: NusA_N; pfam08529 218497002065 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 218497002066 RNA binding site [nucleotide binding]; other site 218497002067 homodimer interface [polypeptide binding]; other site 218497002068 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 218497002069 G-X-X-G motif; other site 218497002070 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 218497002071 G-X-X-G motif; other site 218497002072 Pfam match to entry PF00575 S1, S1 RNA binding domain , score 22.7, E-value 7.1e-06 218497002073 ribosomal protein S1; Region: rpsA; TIGR00717 218497002074 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 218497002075 RNA binding site [nucleotide binding]; other site 218497002076 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 218497002077 RNA binding site [nucleotide binding]; other site 218497002078 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 218497002079 RNA binding site [nucleotide binding]; other site 218497002080 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 218497002081 RNA binding site [nucleotide binding]; other site 218497002082 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 218497002083 RNA binding site [nucleotide binding]; other site 218497002084 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 218497002085 RNA binding site [nucleotide binding]; other site 218497002086 Pfam match to entry PF00575 S1, S1 RNA binding domain , score 84.7, E-value 1.2e-22 218497002087 Pfam match to entry PF00575 S1, S1 RNA binding domain , score 86.0, E-value 5.1e-23 218497002088 Pfam match to entry PF00575 S1, S1 RNA binding domain , score 91.1, E-value 1.4e-24 218497002089 Pfam match to entry PF00575 S1, S1 RNA binding domain , score 87.5, E-value 1.7e-23 218497002090 Pfam match to entry PF00575 S1, S1 RNA binding domain , score 57.8, E-value 1.5e-14 218497002091 Pfam match to entry PF00575 S1, S1 RNA binding domain , score 61.3, E-value 1.4e-15 218497002092 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 218497002093 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 218497002094 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 218497002095 Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase , score 280.0, E-value 2e-81 218497002096 PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. 218497002097 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 218497002098 Pfam match to entry PF01648 ACPS, 4'-phosphopantetheinyl transferase superfamily , score 140.2, E-value 2.4e-39 218497002099 4 probable transmembrane helices predicted for CAB456 by TMHMM2.0 at aa 7-26, 41-60, 90-112 and 116-138 218497002100 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 218497002101 Signal peptide predicted for CAB457 by SignalP 2.0 HMM (Signal peptide probabilty 0.622) with cleavage site probability 0.538 between residues 53 and 54 218497002102 Pfam match to entry PF01790 LGT, Prolipoprotein diacylglyceryl transferase , score 228.0, E-value 8.8e-66 218497002103 6 probable transmembrane helices predicted for CAB457 by TMHMM2.0 at aa 72-94, 109-131, 138-160, 197-216, 223-245 and 260-282 218497002104 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01001 218497002105 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 218497002106 Signal peptide predicted for CAB458 by SignalP 2.0 HMM (Signal peptide probabilty 0.958) with cleavage site probability 0.570 between residues 24 and 25 218497002107 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218497002108 4 probable transmembrane helices predicted for CAB458 by TMHMM2.0 at aa 571-593, 638-660, 691-713 and 739-761 218497002109 Pfam match to entry PF02096 60KD_IMP, 60Kd inner membrane protein , score 358.5, E-value 4.7e-105 218497002110 chromosomal replication initiation protein; Provisional; Region: PRK12422 218497002111 DnaA N-terminal domain; Region: DnaA_N; pfam11638 218497002112 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218497002113 Walker A motif; other site 218497002114 ATP binding site [chemical binding]; other site 218497002115 Walker B motif; other site 218497002116 arginine finger; other site 218497002117 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 218497002118 DnaA box-binding interface [nucleotide binding]; other site 218497002119 Pfam match to entry PF00308 bac_dnaA, Bacterial dnaA protein , score 252.9, E-value 2.8e-73 218497002120 PS00017 ATP/GTP-binding site motif A (P-loop). 218497002121 2 probable transmembrane helices predicted for CAB460 by TMHMM2.0 at aa 63-85 and 89-111 218497002122 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 218497002123 homodimer interface [polypeptide binding]; other site 218497002124 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 218497002125 active site pocket [active] 218497002126 Pfam match to entry PF00343 phosphorylase, Carbohydrate phosphorylase , score 1411.1, E-value 0 218497002127 PS00102 Phosphorylase pyridoxal-phosphate attachment site. 218497002128 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 218497002129 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 218497002130 E3 interaction surface; other site 218497002131 lipoyl attachment site [posttranslational modification]; other site 218497002132 e3 binding domain; Region: E3_binding; pfam02817 218497002133 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 218497002134 Pfam match to entry PF00198 2-oxoacid_dh, 2-oxo acid dehydrogenases acyltransferase (catalytic domain) , score 380.9, E-value 8.4e-112 218497002135 Pfam match to entry PF02817 e3_binding, e3 binding domain , score 57.8, E-value 1.6e-14 218497002136 Pfam match to entry PF00364 biotin_lipoyl, Biotin-requiring enzyme , score 69.5, E-value 4.6e-18 218497002137 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 218497002138 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 218497002139 alpha subunit interface [polypeptide binding]; other site 218497002140 TPP binding site [chemical binding]; other site 218497002141 heterodimer interface [polypeptide binding]; other site 218497002142 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 218497002143 Pfam match to entry PF02780 transketolase_C, Transketolase, C-terminal domain , score 173.6, E-value 2.2e-49 218497002144 Pfam match to entry PF02779 transket_pyr, Transketolase, pyridine binding domain , score 258.4, E-value 6.3e-75 218497002145 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 218497002146 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 218497002147 tetramer interface [polypeptide binding]; other site 218497002148 TPP-binding site [chemical binding]; other site 218497002149 heterodimer interface [polypeptide binding]; other site 218497002150 phosphorylation loop region [posttranslational modification] 218497002151 Pfam match to entry PF00676 E1_dehydrog, Dehydrogenase E1 component , score 253.1, E-value 2.5e-73 218497002152 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 218497002153 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 218497002154 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 218497002155 trimer interface [polypeptide binding]; other site 218497002156 active site 218497002157 UDP-GlcNAc binding site [chemical binding]; other site 218497002158 lipid binding site [chemical binding]; lipid-binding site 218497002159 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats) , score 13.1, E-value 0.45 218497002160 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats) , score 10.8, E-value 2 218497002161 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats) , score 13.8, E-value 0.27 218497002162 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats) , score 16.7, E-value 0.035 218497002163 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats) , score 19.7, E-value 0.0046 218497002164 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats) , score 11.7, E-value 1.1 218497002165 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats) , score 12.8, E-value 0.55 218497002166 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats) , score 13.2, E-value 0.41 218497002167 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 218497002168 Pfam match to entry PF03938 OmpH, Outer membrane protein (OmpH-like) , score 127.0, E-value 2.2e-35 218497002169 Signal peptide predicted for CAB467 by SignalP 2.0 HMM (Signal peptide probabilty 0.996) with cleavage site probability 0.798 between residues 23 and 24 218497002170 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 218497002171 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 218497002172 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 218497002173 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 218497002174 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 218497002175 Surface antigen; Region: Bac_surface_Ag; pfam01103 218497002176 Pfam match to entry PF01103 Bac_surface_Ag, Bacterial surface antigen , score 22.6, E-value 5.5e-08 218497002177 Pfam match to entry PF01103 Bac_surface_Ag, Bacterial surface antigen , score 53.9, E-value 8.2e-18 218497002178 Signal peptide predicted for CAB468 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.997 between residues 25 and 26 218497002179 recombination protein RecR; Reviewed; Region: recR; PRK00076 218497002180 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 218497002181 putative active site [active] 218497002182 putative metal-binding site [ion binding]; other site 218497002183 tetramer interface [polypeptide binding]; other site 218497002184 Pfam match to entry PF01751 Toprim, Toprim domain , score 46.2, E-value 4.8e-11 218497002185 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 218497002186 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 218497002187 dimer interface [polypeptide binding]; other site 218497002188 active site 218497002189 CoA binding pocket [chemical binding]; other site 218497002190 Pfam match to entry PF02797 Chal_stil_syntC, Chalcone and stilbene synthases, C-terminal domain , score 3.9, E-value 3.5e-05 218497002191 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 218497002192 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 218497002193 Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain , score 129.2, E-value 4.9e-36 218497002194 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 218497002195 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 218497002196 NAD(P) binding site [chemical binding]; other site 218497002197 homotetramer interface [polypeptide binding]; other site 218497002198 homodimer interface [polypeptide binding]; other site 218497002199 active site 218497002200 Pfam match to entry PF00106 adh_short, short chain dehydrogenase , score 331.5, E-value 6e-97 218497002201 PS00061 Short-chain dehydrogenases/reductases family signature. 218497002202 acyl carrier protein; Provisional; Region: acpP; PRK00982 218497002203 Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site , score 74.4, E-value 1.5e-19 218497002204 PS00012 Phosphopantetheine attachment site. 218497002205 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 218497002206 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 218497002207 ligand binding site [chemical binding]; other site 218497002208 flexible hinge region; other site 218497002209 Pfam match to entry PF00027 cNMP_binding, Cyclic nucleotide-binding domain , score 68.2, E-value 1.2e-17 218497002210 TLC ATP/ADP transporter; Region: TLC; cl03940 218497002211 11 probable transmembrane helices predicted for CAB475 by TMHMM2.0 at aa 20-39, 54-76, 83-105, 115-137, 150-172, 176-198, 232-254, 274-293, 300-322, 363-385 and 390-412 218497002212 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218497002213 2 probable transmembrane helices predicted for CAB476 by TMHMM2.0 at aa 110-132 and 147-169 218497002214 2 probable transmembrane helices predicted for CAB477 by TMHMM2.0 at aa 127-149 and 164-186 218497002215 Na+-dependent transporters of the SNF family [General function prediction only]; Region: COG0733 218497002216 Pfam match to entry PF00209 SNF, Sodium:neurotransmitter symporter family , score -145.6, E-value 1.3e-14 218497002217 11 probable transmembrane helices predicted for CAB478 by TMHMM2.0 at aa 7-29, 44-66, 87-109, 135-157, 170-189, 249-271, 284-301, 316-338, 351-373, 378-400 and 424-446 218497002218 Signal peptide predicted for CAB478 by SignalP 2.0 HMM (Signal peptide probabilty 0.981) with cleavage site probability 0.764 between residues 24 and 25 218497002219 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 218497002220 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 218497002221 Pfam match to entry PF00375 SDF, Sodium:dicarboxylate symporter family , score 44.5, E-value 7.1e-13 218497002222 8 probable transmembrane helices predicted for CAB480 by TMHMM2.0 at aa 13-35, 41-63, 83-105, 146-165, 178-200, 215-237, 292-314 and 324-346 218497002223 Signal peptide predicted for CAB479 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.524 between residues 25 and 26 218497002224 5 probable transmembrane helices predicted for CAB481 by TMHMM2.0 at aa 57-79, 84-106, 182-204, 209-228 and 249-271 218497002225 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 218497002226 MgtE intracellular N domain; Region: MgtE_N; pfam03448 218497002227 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 218497002228 Divalent cation transporter; Region: MgtE; pfam01769 218497002229 Pfam match to entry PF03448 MgtE_N, MgtE intracellular domain , score 182.8, E-value 3.7e-52 218497002230 Pfam match to entry PF00571 CBS, CBS domain , score 16.5, E-value 0.029 218497002231 Pfam match to entry PF00571 CBS, CBS domain , score 46.6, E-value 3.7e-11 218497002232 5 probable transmembrane helices predicted for CAB483 by TMHMM2.0 at aa 291-313, 320-342, 375-397, 409-431 and 451-469 218497002233 Pfam match to entry PF01769 MgtE, Divalent cation transporter , score 180.6, E-value 1.7e-51 218497002234 Signal peptide predicted for CAB484 by SignalP 2.0 HMM (Signal peptide probabilty 0.835) with cleavage site probability 0.394 between residues 25 and 26 218497002235 1 probable transmembrane helix predicted for CAB484 by TMHMM2.0 at aa 31-53 218497002236 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 218497002237 12 probable transmembrane helices predicted for CAB485 by TMHMM2.0 at aa 12-31, 41-63, 84-106, 121-143, 152-174, 189-211, 232-254, 278-300, 329-348, 358-380, 400-422 and 437-459 218497002238 Pfam match to entry PF00324 aa_permeases, Amino acid permease , score -177.9, E-value 1e-05 218497002239 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 218497002240 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 218497002241 putative active site; other site 218497002242 catalytic residue [active] 218497002243 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 218497002244 2 probable transmembrane helices predicted for CAB487 by TMHMM2.0 at aa 50-72 and 79-101 218497002245 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 218497002246 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218497002247 Walker A/P-loop; other site 218497002248 ATP binding site [chemical binding]; other site 218497002249 Q-loop/lid; other site 218497002250 ABC transporter signature motif; other site 218497002251 Walker B; other site 218497002252 D-loop; other site 218497002253 H-loop/switch region; other site 218497002254 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 218497002255 Pfam match to entry PF00005 ABC_tran, ABC transporter , score 182.9, E-value 3.4e-52 218497002256 PS00017 ATP/GTP-binding site motif A (P-loop). 218497002257 PS00211 ABC transporters family signature. 218497002258 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 218497002259 5 probable transmembrane helices predicted for CAB489 by TMHMM2.0 at aa 20-42, 55-77, 87-109, 153-175 and 185-207 218497002260 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component , score 18.4, E-value 0.00095 218497002261 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 218497002262 Signal peptide predicted for CAB490 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.285 between residues 22 and 23 218497002263 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218497002264 Pfam match to entry PF03180 Lipoprotein_9, NLPA lipoprotein , score 229.4, E-value 3.4e-66 218497002265 Signal peptide predicted for CAB491 by SignalP 2.0 HMM (Signal peptide probabilty 0.628) with cleavage site probability 0.505 between residues 26 and 27 218497002266 3 probable transmembrane helices predicted for CAB491 by TMHMM2.0 at aa 42-61, 100-122 and 126-148 218497002267 Protein of unknown function (DUF721); Region: DUF721; pfam05258 218497002268 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 218497002269 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218497002270 ATP binding site [chemical binding]; other site 218497002271 Mg2+ binding site [ion binding]; other site 218497002272 G-X-G motif; other site 218497002273 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 218497002274 anchoring element; other site 218497002275 dimer interface [polypeptide binding]; other site 218497002276 ATP binding site [chemical binding]; other site 218497002277 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 218497002278 active site 218497002279 putative metal-binding site [ion binding]; other site 218497002280 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 218497002281 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase , score 106.5, E-value 3.3e-29 218497002282 Pfam match to entry PF00204 DNA_gyraseB, DNA gyrase B , score 311.6, E-value 5.9e-91 218497002283 PS00177 DNA topoisomerase II signature. 218497002284 Pfam match to entry PF01751 Toprim, Toprim domain , score 39.9, E-value 3.9e-09 218497002285 Pfam match to entry PF00986 DNA_gyraseB_C, DNA gyrase B subunit, carboxyl terminus , score 151.4, E-value 1e-42 218497002286 DNA gyrase, A subunit; Region: gyrA; TIGR01063 218497002287 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 218497002288 CAP-like domain; other site 218497002289 active site 218497002290 primary dimer interface [polypeptide binding]; other site 218497002291 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 218497002292 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 218497002293 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 218497002294 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 218497002295 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 218497002296 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 218497002297 Pfam match to entry PF00521 DNA_topoisoIV, DNA gyrase/topoisomerase IV, subunit A , score 980.0, E-value 3.8e-292 218497002298 Pfam match to entry PF03989 DNA_gyraseA_C, DNA gyrase C-terminal domain, beta-propeller , score 45.0, E-value 1.1e-10 218497002299 Pfam match to entry PF03989 DNA_gyraseA_C, DNA gyrase C-terminal domain, beta-propeller , score 49.3, E-value 5.6e-12 218497002300 Pfam match to entry PF03989 DNA_gyraseA_C, DNA gyrase C-terminal domain, beta-propeller , score 37.7, E-value 1.8e-08 218497002301 Pfam match to entry PF03989 DNA_gyraseA_C, DNA gyrase C-terminal domain, beta-propeller , score 62.0, E-value 8.1e-16 218497002302 Pfam match to entry PF03989 DNA_gyraseA_C, DNA gyrase C-terminal domain, beta-propeller , score 48.6, E-value 8.8e-12 218497002303 Pfam match to entry PF03989 DNA_gyraseA_C, DNA gyrase C-terminal domain, beta-propeller , score 54.0, E-value 2.2e-13 218497002304 thymidylate kinase; Validated; Region: tmk; PRK00698 218497002305 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 218497002306 TMP-binding site; other site 218497002307 ATP-binding site [chemical binding]; other site 218497002308 Pfam match to entry PF02223 Thymidylate_kin, Thymidylate kinase , score 236.6, E-value 2.4e-68 218497002309 PS00017 ATP/GTP-binding site motif A (P-loop). 218497002310 PS01331 Thymidylate kinase signature. 218497002311 DNA polymerase III subunit delta'; Validated; Region: PRK05917 218497002312 Predicted helix-turn-helix motif with score 1067.000, SD 2.82 at aa 181-202, sequence MSITEVGKIVKGSVDTDKQVLR 218497002313 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 218497002314 Serine hydrolase (FSH1); Region: FSH1; pfam03959 218497002315 Pfam match to entry PF02230 abhydrolase_2, Phospholipase/Carboxylesterase , score 257.2, E-value 1.4e-74 218497002316 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 218497002317 Pfam match to entry PF01300 Sua5_yciO_yrdC, yrdC domain , score 87.5, E-value 1.8e-23 218497002318 PS01147 SUA5/yciO/yrdC family signature. 218497002319 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 218497002320 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 218497002321 active site 218497002322 IncA protein; Region: IncA; pfam04156 218497002323 2 probable transmembrane helices predicted for CAB500 by TMHMM2.0 at aa 39-61 and 65-87 218497002324 HOOK protein; Region: HOOK; pfam05622 218497002325 4 probable transmembrane helices predicted for CAB501 by TMHMM2.0 at aa 37-59, 69-91, 147-169 and 174-196 218497002326 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 218497002327 Pfam match to entry PF03641 Lysine_decarbox, Lysine decarboxylase , score 38.0, E-value 1.4e-08 218497002328 Signal peptide predicted for CAB502 by SignalP 2.0 HMM (Signal peptide probabilty 0.937) with cleavage site probability 0.374 between residues 23 and 24 218497002329 prenyltransferase; Reviewed; Region: ubiA; PRK12876 218497002330 UbiA prenyltransferase family; Region: UbiA; pfam01040 218497002331 Signal peptide predicted for CAB503 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.993 between residues 32 and 33 218497002332 Pfam match to entry PF01040 UbiA, UbiA prenyltransferase , score 150.6, E-value 1.8e-42 218497002333 8 probable transmembrane helices predicted for CAB503 by TMHMM2.0 at aa 49-71, 92-114, 119-136, 141-163, 173-195, 218-240, 245-267 and 279-298 218497002334 aromatic acid decarboxylase; Validated; Region: PRK05920 218497002335 Flavoprotein; Region: Flavoprotein; pfam02441 218497002336 Signal peptide predicted for CAB504 by SignalP 2.0 HMM (Signal peptide probabilty 0.723) with cleavage site probability 0.698 between residues 17 and 18 218497002337 Pfam match to entry PF02441 Flavoprotein, Flavoprotein , score 158.1, E-value 1e-44 218497002338 Uncharacterized conserved protein [Function unknown]; Region: COG1284 218497002339 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 218497002340 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 218497002341 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 218497002342 6 probable transmembrane helices predicted for CAB505 by TMHMM2.0 at aa 47-66, 81-103, 110-132, 152-169, 190-212 and 217-239 218497002343 Pfam match to entry PF02588 DUF161, Uncharacterized BCR, YitT family COG1284 , score 74.0, E-value 2.1e-19 218497002344 Pfam match to entry PF02588 DUF161, Uncharacterized BCR, YitT family COG1284 , score 75.9, E-value 5.6e-20 218497002345 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218497002346 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 218497002347 Pfam match to entry PF01975 SurE, Survival protein SurE , score 210.8, E-value 1.3e-60 218497002348 PS00017 ATP/GTP-binding site motif A (P-loop). 218497002349 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 218497002350 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 218497002351 Ligand Binding Site [chemical binding]; other site 218497002352 Pfam match to entry PF01171 UPF0021, Uncharacterized protein family UPF0021 , score -68.4, E-value 4e-05 218497002353 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 218497002354 SEC-C motif; Region: SEC-C; pfam02810 218497002355 Pfam match to entry PF02810 SEC-C, SEC-C motif , score 41.3, E-value 1.4e-09 218497002356 PS00430 TonB-dependent receptor proteins signature 1. 218497002357 1 probable transmembrane helix predicted for CAB509 by TMHMM2.0 at aa 250-272 218497002358 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 218497002359 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 218497002360 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218497002361 FeS/SAM binding site; other site 218497002362 PS01278 Uncharacterized protein family UPF0004 signature. 218497002363 Pfam match to entry PF00919 UPF0004, Uncharacterized protein family UPF0004 , score 148.6, E-value 7.3e-42 218497002364 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 218497002365 Pfam match to entry PF00471 Ribosomal_L33, Ribosomal protein L33 , score 54.9, E-value 1.2e-13 218497002366 PS00582 Ribosomal protein L33 signature. 218497002367 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 218497002368 FtsX-like permease family; Region: FtsX; pfam02687 218497002369 4 probable transmembrane helices predicted for CAB514 by TMHMM2.0 at aa 21-43, 364-386, 407-429 and 464-486 218497002370 Pfam match to entry PF02687 DUF214, Predicted permease , score 107.1, E-value 2.2e-29 218497002371 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 218497002372 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 218497002373 Walker A/P-loop; other site 218497002374 ATP binding site [chemical binding]; other site 218497002375 Q-loop/lid; other site 218497002376 ABC transporter signature motif; other site 218497002377 Walker B; other site 218497002378 D-loop; other site 218497002379 H-loop/switch region; other site 218497002380 Pfam match to entry PF00005 ABC_tran, ABC transporter , score 175.6, E-value 5.2e-50 218497002381 PS00017 ATP/GTP-binding site motif A (P-loop). 218497002382 Predicted helix-turn-helix motif with score 981.000, SD 2.53 at aa 123-144, sequence KKALELIDSVGLSHRTHSRCCN 218497002383 PS00211 ABC transporters family signature. 218497002384 Similar to several Chlamydia proteins of undefined function including: Chlamydophila caviae hypothetical protein Cca00530 SWALL:Q822Z6 (EMBL:AE016995) (424 aa) fasta scores: E(): 1.2e-106, 58.29% id in 422 aa and Chlamydophila pneumoniae TW-183 hypothetical protein Cpb0363 SWALL:AAP98294 (EMBL:AE017158) (433 aa) fasta scores: E(): 4.9e-17, 24.25% id in 437 aa. Appears to have a frameshift mutation following codon 110 which occurs in a homopolymeric tract. This leaves open the possibility that the expression of its protein product may be subject to phase variation.;conserved membrane protein (pseudogene) 218497002385 homopolymeric tract in which the frameshift occurs 218497002386 2 probable transmembrane helices predicted for CAB517 by TMHMM2.0 at aa 32-54 and 58-80 218497002387 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 218497002388 23S rRNA interface [nucleotide binding]; other site 218497002389 L3 interface [polypeptide binding]; other site 218497002390 Pfam match to entry PF00572 Ribosomal_L13, Ribosomal protein L13 , score 187.4, E-value 1.5e-53 218497002391 PS00063 Aldo/keto reductase active site signature. 218497002392 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 218497002393 Pfam match to entry PF00380 Ribosomal_S9, Ribosomal protein S9/S16 , score 142.7, E-value 4.1e-40 218497002394 PS00360 Ribosomal protein S9 signature. 218497002395 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 218497002396 NlpC/P60 family; Region: NLPC_P60; cl17555 218497002397 Pfam match to entry PF00877 NLPC_P60, NLP/P60 family , score -1.9, E-value 0.00021 218497002398 adenylate kinase; Reviewed; Region: adk; PRK00279 218497002399 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 218497002400 AMP-binding site [chemical binding]; other site 218497002401 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 218497002402 Pfam match to entry PF00406 adenylatekinase, Adenylate kinase , score 232.8, E-value 3.2e-67 218497002403 2 probable transmembrane helices predicted for CAB522 by TMHMM2.0 at aa 195-217 and 227-249 218497002404 2 probable transmembrane helices predicted for CAB523 by TMHMM2.0 at aa 28-50 and 82-104 218497002405 3 probable transmembrane helices predicted for CAB524 by TMHMM2.0 at aa 117-139, 208-230 and 245-267 218497002406 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 218497002407 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 218497002408 putative active site [active] 218497002409 Pfam match to entry PF01182 Glucosamine_iso, Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase , score -71.3, E-value 0.002 218497002410 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 218497002411 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 218497002412 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 218497002413 Pfam match to entry PF02781 G6PD_C, Glucose-6-phosphate dehydrogenase, C-terminal domain , score 449.6, E-value 1.7e-132 218497002414 Pfam match to entry PF00479 G6PD, Glucose-6-phosphate dehydrogenase, NAD binding domain , score 240.3, E-value 1.8e-69 218497002415 PS00069 Glucose-6-phosphate dehydrogenase active site. 218497002416 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 218497002417 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 218497002418 peptide binding site [polypeptide binding]; other site 218497002419 Pfam match to entry PF00496 SBP_bac_5, Bacterial extracellular solute-binding proteins, family 5 , score 199.3, E-value 3.9e-57 218497002420 Signal peptide predicted for CAB527 by SignalP 2.0 HMM (Signal peptide probabilty 0.961) with cleavage site probability 0.673 between residues 22 and 23 218497002421 UGMP family protein; Validated; Region: PRK09604 218497002422 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 218497002423 Pfam match to entry PF00814 Peptidase_M22, Glycoprotease , score 392.9, E-value 2.1e-115 218497002424 Similar to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri arginine repressor ArgR or XerA or b3237 or z4596 or ecs4110 or sf3277 or s3492 SWALL:ARGR_ECOLI (SWALL:P15282) (156 aa) fasta scores: E(): 3.2e-10, 39.04% id in 146 aa and to Haemophilus influenzae arginine repressor ArgR or hi1209 SWALL:ARGR_HAEIN (SWALL:P45110) (151 aa) fasta scores: E(): 9.3e-13, 39.72% id in 146 aa. Appears to have undergone a frameshift mutation following codon 57.;arginine repressor (pseudogene) 218497002425 Pfam match to entry PF02863 Arg_repressor_C, Arginine repressor, C-terminal domain , score 103.1, E-value 3.6e-28 218497002426 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 218497002427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218497002428 dimer interface [polypeptide binding]; other site 218497002429 conserved gate region; other site 218497002430 putative PBP binding loops; other site 218497002431 ABC-ATPase subunit interface; other site 218497002432 3 probable transmembrane helices predicted for CAB530 by TMHMM2.0 at aa 15-37, 58-80 and 187-209 218497002433 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component , score 55.1, E-value 1e-13 218497002434 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218497002435 7xpoly G tract 218497002436 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 218497002437 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218497002438 Walker A/P-loop; other site 218497002439 ATP binding site [chemical binding]; other site 218497002440 Q-loop/lid; other site 218497002441 ABC transporter signature motif; other site 218497002442 Walker B; other site 218497002443 D-loop; other site 218497002444 H-loop/switch region; other site 218497002445 Pfam match to entry PF00005 ABC_tran, ABC transporter , score 177.4, E-value 1.5e-50 218497002446 PS00017 ATP/GTP-binding site motif A (P-loop). 218497002447 PS00211 ABC transporters family signature. 218497002448 Signal peptide predicted for CAB533 by SignalP 2.0 HMM (Signal peptide probabilty 0.990) with cleavage site probability 0.515 between residues 31 and 32 218497002449 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 218497002450 Uncharacterized protein conserved in archaea (DUF2250); Region: DUF2250; pfam10007 218497002451 Pfam match to entry PF03631 Ribonuclease_BN, Ribonuclease BN-like family , score 15.7, E-value 2.3e-07 218497002452 6 probable transmembrane helices predicted for CAB534 by TMHMM2.0 at aa 46-65, 105-127, 148-170, 193-215, 228-250 and 265-287 218497002453 Methyltransferase domain; Region: Methyltransf_31; pfam13847 218497002454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218497002455 S-adenosylmethionine binding site [chemical binding]; other site 218497002456 IncA protein; Region: IncA; pfam04156 218497002457 2 probable transmembrane helices predicted for CAB536 by TMHMM2.0 at aa 71-93 and 98-117 218497002458 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 218497002459 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 218497002460 substrate binding site [chemical binding]; other site 218497002461 hexamer interface [polypeptide binding]; other site 218497002462 metal binding site [ion binding]; metal-binding site 218497002463 Signal peptide predicted for CAB537 by SignalP 2.0 HMM (Signal peptide probabilty 0.619) with cleavage site probability 0.346 between residues 24 and 25 218497002464 Pfam match to entry PF00834 Ribul_P_3_epim, Ribulose-phosphate 3 epimerase , score 279.7, E-value 2.5e-81 218497002465 PS01085 Ribulose-phosphate 3-epimerase signature 1. 218497002466 PS01086 Ribulose-phosphate 3-epimerase signature 2. 218497002467 elongation factor P; Provisional; Region: PRK12426 218497002468 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 218497002469 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 218497002470 RNA binding site [nucleotide binding]; other site 218497002471 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 218497002472 RNA binding site [nucleotide binding]; other site 218497002473 Pfam match to entry PF01132 EFP, Elongation factor P (EF-P) , score 105.7, E-value 5.8e-29 218497002474 PS01275 Elongation factor P signature. 218497002475 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 218497002476 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 218497002477 carboxyltransferase (CT) interaction site; other site 218497002478 biotinylation site [posttranslational modification]; other site 218497002479 Pfam match to entry PF00364 biotin_lipoyl, Biotin-requiring enzyme , score 102.8, E-value 4.4e-28 218497002480 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 218497002481 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 218497002482 ATP-grasp domain; Region: ATP-grasp_4; cl17255 218497002483 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 218497002484 Pfam match to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase L chain, N-terminal domain , score 159.7, E-value 3.3e-45 218497002485 Pfam match to entry PF02786 CPSase_L_D2, Carbamoyl-phosphate synthase L chain, ATP binding domain , score 341.2, E-value 7.7e-100 218497002486 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 218497002487 Pfam match to entry PF02785 Biotin_carb_C, Biotin carboxylase C-terminal domain , score 222.3, E-value 4.7e-64 218497002488 Pseudogene. Similar to Chlamydophila caviae hypothetical protein CCA00555 SWALL:Q822X3 (EMBL:AE016996) (484 aa) fasta scores: E(): 5.1e-109, 57.75% id in 490 aa. This CDS has multiple frameshift mutations;conserved membrane protein (pseudogene) 218497002489 1 probable transmembrane helix predicted for CAB541 by TMHMM2.0 at aa 43-65 218497002490 Pseudogene. Similar to Chlamydophila caviae hypothetical protein cca00556 SWALL:Q822X2 (EMBL:AE016996) (548 aa) fasta scores: E(): 1.9e-123, 58.79% id in 546 aa. The frameshift in this CDS occurs within a homopolymeric tract leaving open the possibility that the expression of the protein product of this CDS is subject to phase variation;conserved inner membrane protein (pseudogene) 218497002491 homopolmeric tract in which the frameshift occurs 218497002492 2 probable transmembrane helices predicted for CAB545 by TMHMM2.0 at aa 31-53 and 58-80 218497002493 Family of unknown function (DUF648); Region: DUF648; pfam04890 218497002494 1 probable transmembrane helix predicted for CAB547 by TMHMM2.0 at aa 63-85 218497002495 Protein of unknown function (DUF1389); Region: DUF1389; pfam07146 218497002496 1 probable transmembrane helix predicted for CAB549 by TMHMM2.0 at aa 75-97 218497002497 Pseudogene. Similar to Aquifex aeolicus inosine-5'-monophosphate dehydrogenase GuaB or AQ_2023 SWALL:IMDH_AQUAE (SWALL:O67820) (490 aa) fasta scores: E(): 1.6e-48, 40.48% id in 457 aa, and to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri inosine-5'-monophosphate dehydrogenase GuaB or GuaR or B2508 or Z3772 or ECS3370 or SF2554 or S2726 SWALL:IMDH_ECOLI (SWALL:P06981) (488 aa) fasta scores: E(): 8.4e-46, 39.56% id in 455 aa. This CDS carries a frameshift mutation and a premature stop codon within its sequence and appears to be missing the very C-terminal region.;inosine-5'-monophosphate dehydrogenase (pseudogene) 218497002498 Pfam match to entry PF00478 IMPDH, IMP dehydrogenase / GMP reductase , score 78.4, E-value 9.8e-21 218497002499 PS00487 IMP dehydrogenase / GMP reductase signature. 218497002500 Pfam match to entry PF00478 IMPDH, IMP dehydrogenase / GMP reductase , score 149.6, E-value 1.4e-42 218497002501 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 218497002502 putative active site pocket [active] 218497002503 dimerization interface [polypeptide binding]; other site 218497002504 putative catalytic residue [active] 218497002505 Signal peptide predicted for CAB553 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.678 between residues 25 and 26 218497002506 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218497002507 2 probable transmembrane helices predicted for CAB554 by TMHMM2.0 at aa 43-65 and 72-94 218497002508 Pseudogene. Similar to Chlamydophila caviae hypothetical protein CCA00578 SWALL:Q822V1 (EMBL:AE016996) (280 aa) fasta scores: E(): 1.2e-66, 66.01% id in 256 aa, and to Chlamydia pneumoniae hypothetical protein CPN0177 or CPJ0177 or CP0592 SWALL:Q9Z907 (EMBL:AE001604) (284 aa) fasta scores: E(): 2.7e-07, 25.44% id in 224 aa. This CDS carries a premature stop codon and a C-terminal sequence deletion.;conserved hypothetical lipoprotein (pseudogene) 218497002509 Signal peptide predicted for CAB555 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.470 between residues 28 and 29 218497002510 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218497002511 2 probable transmembrane helices predicted for CAB557 by TMHMM2.0 at aa 90-112 and 117-139 218497002512 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 218497002513 Pfam match to entry PF02592 DUF165, Uncharacterized ACR, YhhQ family COG1738 , score 208.9, E-value 5e-60 218497002514 6 probable transmembrane helices predicted for CAB558 by TMHMM2.0 at aa 12-34, 49-71, 84-103, 118-140, 165-187 and 192-214 218497002515 queuine tRNA-ribosyltransferase; Provisional; Region: PRK01008 218497002516 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 218497002517 Pfam match to entry PF01702 TGT, Queuine tRNA-ribosyltransferase , score 178.1, E-value 9.1e-51 218497002518 3 probable transmembrane helices predicted for CAB560 by TMHMM2.0 at aa 56-78, 88-110 and 117-136 218497002519 hypothetical protein; Validated; Region: PRK05868 218497002520 Similar to Chlamydophila caviae hypothetical protein cca00584 SWALL:Q822U5 (EMBL:AE016996) (275 aa) fasta scores: E(): 5e-14, 46.35% id in 274 aa. Note the premature in-frame stop codon following codon 9; inner membrane protein (pseudogene) 218497002521 1 probable transmembrane helix predicted for CAB561 by TMHMM2.0 at aa 28-50 218497002522 putative disulfide oxidoreductase; Provisional; Region: PRK00611 218497002523 Pfam match to entry PF02600 DsbB, Disulfide bond formation protein DsbB , score 173.9, E-value 1.7e-49 218497002524 4 probable transmembrane helices predicted for CAB562 by TMHMM2.0 at aa 7-29, 39-56, 63-85 and 105-127 218497002525 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218497002526 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 218497002527 Thioredoxin; Region: Thioredoxin_4; cl17273 218497002528 Signal peptide predicted for CAB563 by SignalP 2.0 HMM (Signal peptide probabilty 0.771) with cleavage site probability 0.624 between residues 24 and 25 218497002529 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729 218497002530 Signal peptide predicted for CAB564 by SignalP 2.0 HMM (Signal peptide probabilty 0.747) with cleavage site probability 0.741 between residues 63 and 64 218497002531 9 probable transmembrane helices predicted for CAB564 by TMHMM2.0 at aa 92-109, 116-138, 194-213, 226-245, 250-272, 327-344, 359-376, 383-405 and 409-426 218497002532 2 probable transmembrane helices predicted for CAB565 by TMHMM2.0 at aa 44-66 and 81-103 218497002533 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 218497002534 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218497002535 Walker A/P-loop; other site 218497002536 ATP binding site [chemical binding]; other site 218497002537 Q-loop/lid; other site 218497002538 ABC transporter signature motif; other site 218497002539 Walker B; other site 218497002540 D-loop; other site 218497002541 H-loop/switch region; other site 218497002542 Pfam match to entry PF00005 ABC_tran, ABC transporter , score 176.2, E-value 3.5e-50 218497002543 PS00017 ATP/GTP-binding site motif A (P-loop). 218497002544 Pseudogene. Similar to Chlamydophila caviae 5'-methylthioadenosine nucleosidase-related protein CCA00593 SWALL:Q822T6 (EMBL:AE016996) (297 aa) fasta scores: E(): 7e-100, 82.49% id in 297 aa, and to Ralstonia solanacearum probable bifunctional protein Pfs or RSC3374 or RS02649 SWALL:Q8XU20 (EMBL:AL646075) (261 aa) fasta scores: E(): 6.6e-08, 23.73% id in 257 aa. Note this CDS carries multiple frameshift mutations.;conserved hypothetical protein (pseudogene) 218497002545 Signal peptide predicted for CAB568 by SignalP 2.0 HMM (Signal peptide probabilty 0.986) with cleavage site probability 0.959 between residues 55 and 56 218497002546 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 218497002547 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 218497002548 Ligand binding site; other site 218497002549 oligomer interface; other site 218497002550 Pfam match to entry PF02348 CTP_transf_3, Cytidylyltransferase , score 301.0, E-value 9.5e-88 218497002551 CTP synthetase; Validated; Region: pyrG; PRK05380 218497002552 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 218497002553 Catalytic site [active] 218497002554 active site 218497002555 UTP binding site [chemical binding]; other site 218497002556 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 218497002557 active site 218497002558 putative oxyanion hole; other site 218497002559 catalytic triad [active] 218497002560 Signal peptide predicted for CAB570 by SignalP 2.0 HMM (Signal peptide probabilty 0.880) with cleavage site probability 0.423 between residues 22 and 23 218497002561 Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I , score 221.7, E-value 6.9e-64 218497002562 PS00442 Glutamine amidotransferases class-I active site. 218497002563 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 218497002564 Pfam match to entry PF03652 UPF0081, Uncharacterised protein family (UPF0081) , score 177.5, E-value 1.4e-50 218497002565 1 probable transmembrane helix predicted for CAB571 by TMHMM2.0 at aa 20-39 218497002566 PS00017 ATP/GTP-binding site motif A (P-loop). 218497002567 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 218497002568 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 218497002569 Signal peptide predicted for CAB572 by SignalP 2.0 HMM (Signal peptide probabilty 0.966) with cleavage site probability 0.446 between residues 35 and 36 218497002570 Pfam match to entry PF00496 SBP_bac_5, Bacterial extracellular solute-binding proteins, family 5 , score 28.2, E-value 4e-16 218497002571 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218497002572 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 218497002573 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 218497002574 peptide binding site [polypeptide binding]; other site 218497002575 Pfam match to entry PF00496 SBP_bac_5, Bacterial extracellular solute-binding proteins, family 5 , score 223.3, E-value 2.4e-64 218497002576 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218497002577 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 218497002578 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 218497002579 peptide binding site [polypeptide binding]; other site 218497002580 Signal peptide predicted for CAB574 by SignalP 2.0 HMM (Signal peptide probabilty 0.909) with cleavage site probability 0.720 between residues 26 and 27 218497002581 Pfam match to entry PF00496 SBP_bac_5, Bacterial extracellular solute-binding proteins, family 5 , score 181.7, E-value 7.5e-52 218497002582 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 218497002583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218497002584 dimer interface [polypeptide binding]; other site 218497002585 conserved gate region; other site 218497002586 putative PBP binding loops; other site 218497002587 ABC-ATPase subunit interface; other site 218497002588 Signal peptide predicted for CAB575 by SignalP 2.0 HMM (Signal peptide probabilty 0.935) with cleavage site probability 0.577 between residues 28 and 29 218497002589 6 probable transmembrane helices predicted for CAB575 by TMHMM2.0 at aa 89-111, 132-154, 174-196, 216-238, 242-264 and 277-299 218497002590 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component , score 19.4, E-value 0.00075 218497002591 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 218497002592 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 218497002593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218497002594 dimer interface [polypeptide binding]; other site 218497002595 conserved gate region; other site 218497002596 putative PBP binding loops; other site 218497002597 ABC-ATPase subunit interface; other site 218497002598 6 probable transmembrane helices predicted for CAB576 by TMHMM2.0 at aa 25-47, 85-107, 122-144, 151-173, 209-231 and 252-274 218497002599 Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component , score 50.0, E-value 3.3e-12 218497002600 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218497002601 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 218497002602 Walker A/P-loop; other site 218497002603 ATP binding site [chemical binding]; other site 218497002604 Q-loop/lid; other site 218497002605 ABC transporter signature motif; other site 218497002606 Walker B; other site 218497002607 D-loop; other site 218497002608 H-loop/switch region; other site 218497002609 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 218497002610 Pfam match to entry PF00005 ABC_tran, ABC transporter , score 165.1, E-value 7.9e-47 218497002611 PS00017 ATP/GTP-binding site motif A (P-loop). 218497002612 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 218497002613 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 218497002614 Walker A/P-loop; other site 218497002615 ATP binding site [chemical binding]; other site 218497002616 Q-loop/lid; other site 218497002617 ABC transporter signature motif; other site 218497002618 Walker B; other site 218497002619 D-loop; other site 218497002620 H-loop/switch region; other site 218497002621 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 218497002622 Pfam match to entry PF00005 ABC_tran, ABC transporter , score 206.1, E-value 3.5e-59 218497002623 PS00017 ATP/GTP-binding site motif A (P-loop). 218497002624 PS00211 ABC transporters family signature. 218497002625 Protein of unknown function (DUF1186); Region: DUF1186; pfam06685 218497002626 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 218497002627 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 218497002628 transmembrane helices; other site 218497002629 Signal peptide predicted for CAB580 by SignalP 2.0 HMM (Signal peptide probabilty 0.961) with cleavage site probability 0.684 between residues 28 and 29 218497002630 Pfam match to entry PF00939 Na_sulph_symp, Sodium:sulfate symporter transmembrane region , score 869.7, E-value 5.9e-259 218497002631 9 probable transmembrane helices predicted for CAB580 by TMHMM2.0 at aa 44-66, 182-204, 214-236, 266-284, 289-311, 324-346, 361-378, 390-412 and 442-464 218497002632 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 218497002633 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 218497002634 active site 218497002635 ADP/pyrophosphate binding site [chemical binding]; other site 218497002636 dimerization interface [polypeptide binding]; other site 218497002637 allosteric effector site; other site 218497002638 fructose-1,6-bisphosphate binding site; other site 218497002639 Pfam match to entry PF00365 PFK, Phosphofructokinase , score -54.1, E-value 5.3e-10 218497002640 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 218497002641 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 218497002642 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 218497002643 1 probable transmembrane helix predicted for CAB582 by TMHMM2.0 at aa 13-35 218497002644 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 218497002645 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 218497002646 active site 218497002647 ADP/pyrophosphate binding site [chemical binding]; other site 218497002648 dimerization interface [polypeptide binding]; other site 218497002649 allosteric effector site; other site 218497002650 fructose-1,6-bisphosphate binding site; other site 218497002651 Pfam match to entry PF00365 PFK, Phosphofructokinase , score -69.0, E-value 4.8e-09 218497002652 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 218497002653 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 218497002654 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 218497002655 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 218497002656 HIGH motif; other site 218497002657 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 218497002658 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 218497002659 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 218497002660 active site 218497002661 KMSKS motif; other site 218497002662 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 218497002663 tRNA binding surface [nucleotide binding]; other site 218497002664 Pfam match to entry PF00133 tRNA-synt_1, tRNA synthetases class I (I, L, M and V) , score 419.8, E-value 1.6e-123 218497002665 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 218497002666 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 218497002667 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 218497002668 Signal peptide predicted for CAB586 by SignalP 2.0 HMM (Signal peptide probability 0.999) with cleavage site probability 0.932 between residues 20 and 21 218497002669 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 218497002670 TrkA-N domain; Region: TrkA_N; pfam02254 218497002671 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 218497002672 3 probable transmembrane helices predicted for CAB588 by TMHMM2.0 at aa 73-95, 99-118 and 830-852 218497002673 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 218497002674 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 218497002675 nucleotide binding pocket [chemical binding]; other site 218497002676 K-X-D-G motif; other site 218497002677 catalytic site [active] 218497002678 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 218497002679 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 218497002680 Helix-hairpin-helix motif; Region: HHH; pfam00633 218497002681 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 218497002682 Dimer interface [polypeptide binding]; other site 218497002683 BRCT sequence motif; other site 218497002684 Pfam match to entry PF00533 BRCT, BRCA1 C Terminus (BRCT) domain , score 50.9, E-value 1.8e-12 218497002685 Pfam match to entry PF00633 HHH, Helix-hairpin-helix motif , score 33.4, E-value 3.4e-07 218497002686 Pfam match to entry PF03119 DNA_ligase_ZBD, NAD-dependent DNA ligase C4 zinc finger domain , score 42.0, E-value 8.9e-10 218497002687 Pfam match to entry PF03120 DNA_ligase_OB, NAD-dependent DNA ligase OB-fold domain , score 181.9, E-value 6.6e-52 218497002688 PS01056 NAD-dependent DNA ligase signature 2. 218497002689 Pfam match to entry PF01653 DNA_ligase_N, NAD-dependent DNA ligase adenylation domain , score 371.9, E-value 4.3e-109 218497002690 Catalytic domain of Protein Kinases; Region: PKc; cd00180 218497002691 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 218497002692 active site 218497002693 ATP binding site [chemical binding]; other site 218497002694 substrate binding site [chemical binding]; other site 218497002695 activation loop (A-loop); other site 218497002696 Uncharacterized conserved protein [Function unknown]; Region: COG1262 218497002697 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 218497002698 Pfam match to entry PF03781 DUF323, Domain of unknown function (DUF323) , score 310.8, E-value 1e-90 218497002699 Pfam match to entry PF00069 pkinase, Protein kinase domain , score 13.3, E-value 0.00087 218497002700 IncA protein; Region: IncA; pfam04156 218497002701 2 probable transmembrane helices predicted for CAB591 by TMHMM2.0 at aa 49-71 and 81-103 218497002702 2 probable transmembrane helices predicted for CAB593 by TMHMM2.0 at aa 40-62 and 67-89 218497002703 Uncharacterized conserved protein [Function unknown]; Region: COG2912 218497002704 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 218497002705 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 218497002706 TPR motif; other site 218497002707 binding surface 218497002708 Similar to Chlamydia pneumoniae probable outer membrane protein pmp10 precursor or omp5 or cp0303 SWALL:PM10_CHLPN (SWALL:Q9RB65) (928 aa) fasta scores: E(): 8.4e-111, 41.5% id in 959 aa, and to Chlamydophila abortus pomp91b precursor SWALL:P71133 (EMBL:U65943) (846 aa) fasta scores: E(): 0, 97.75% id in 846 aa. Note the frameshift mutation within this CDS occurs in a homopolymeric tract,consequently the expression of its outer-membrane protein product is thought to be phase variable;polymorphic outer membrane protein (pseudogene) 218497002709 Signal peptide predicted for CAB596 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.983 between residues 23 and 24 218497002710 Pfam match to entry PF02415 DUF145, Chlamydia protein of unknown function , score 689.1, E-value 1.4e-204 218497002711 16 x poly G tract and the site of the frameshift. This is a candidate site for phase variation of the expression of this gene 218497002712 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 218497002713 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 218497002714 Autotransporter beta-domain; Region: Autotransporter; pfam03797 218497002715 Signal peptide predicted for CAB598 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.956 between residues 23 and 24 218497002716 Pfam match to entry PF02415 DUF145, Chlamydia protein of unknown function , score 692.5, E-value 1.3e-205 218497002717 15 x poly G tract. Possible site for phase variation 218497002718 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 218497002719 Clp amino terminal domain; Region: Clp_N; pfam02861 218497002720 Clp amino terminal domain; Region: Clp_N; pfam02861 218497002721 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218497002722 Walker A motif; other site 218497002723 ATP binding site [chemical binding]; other site 218497002724 Walker B motif; other site 218497002725 arginine finger; other site 218497002726 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218497002727 Walker A motif; other site 218497002728 ATP binding site [chemical binding]; other site 218497002729 Walker B motif; other site 218497002730 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 218497002731 PS00017 ATP/GTP-binding site motif A (P-loop). 218497002732 Pfam match to entry PF00004 AAA, ATPase associated with various cellular activities (AAA) , score 36.4, E-value 4.1e-08 218497002733 PS00870 Chaperonins clpA/B signature 1. 218497002734 PS00017 ATP/GTP-binding site motif A (P-loop). 218497002735 Pfam match to entry PF02861 Clp_N, Clp amino terminal domain , score 49.3, E-value 5.5e-12 218497002736 Pfam match to entry PF02861 Clp_N, Clp amino terminal domain , score 28.8, E-value 8.2e-06 218497002737 mce related protein; Region: MCE; pfam02470 218497002738 Signal peptide predicted for CAB600 by SignalP 2.0 HMM (Signal peptide probabilty 0.840) with cleavage site probability 0.575 between residues 34 and 35 218497002739 1 probable transmembrane helix predicted for CAB600 by TMHMM2.0 at aa 7-29 218497002740 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 218497002741 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218497002742 Walker A/P-loop; other site 218497002743 ATP binding site [chemical binding]; other site 218497002744 Q-loop/lid; other site 218497002745 ABC transporter signature motif; other site 218497002746 Walker B; other site 218497002747 D-loop; other site 218497002748 H-loop/switch region; other site 218497002749 Pfam match to entry PF00005 ABC_tran, ABC transporter , score 163.0, E-value 3.3e-46 218497002750 PS00017 ATP/GTP-binding site motif A (P-loop). 218497002751 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 218497002752 Permease; Region: Permease; pfam02405 218497002753 7 probable transmembrane helices predicted for CAB602 by TMHMM2.0 at aa 9-31, 51-73, 86-108, 128-150, 157-179, 194-216 and 237-259 218497002754 Pfam match to entry PF02405 DUF140, Domain of unknown function DUF140 , score 158.5, E-value 7.4e-45 218497002755 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00615 218497002756 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 218497002757 inhibitor-cofactor binding pocket; inhibition site 218497002758 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218497002759 catalytic residue [active] 218497002760 Pfam match to entry PF00202 aminotran_3, Aminotransferase class-III , score 114.1, E-value 1.7e-31 218497002761 hypothetical protein; Validated; Region: PRK00228 218497002762 Pfam match to entry PF02622 DUF179, Uncharacterized ACR, COG1678 , score 346.0, E-value 2.8e-101 218497002763 Uncharacterized conserved protein [Function unknown]; Region: COG1259 218497002764 Pfam match to entry PF02577 DUF151, Uncharacterized ACR, COG1259 , score 250.6, E-value 1.4e-72 218497002765 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 218497002766 tetramer (dimer of dimers) interface [polypeptide binding]; other site 218497002767 active site 218497002768 dimer interface [polypeptide binding]; other site 218497002769 Pfam match to entry PF00455 deoR, Bacterial regulatory proteins, deoR family , score 16.9, E-value 8.6e-05 218497002770 Similar to Chlamydophila caviae hypothetical protein cca00634 SWALL:Q822P5 (EMBL:AE016996) (416 aa) fasta scores: E(): 1.2e-89, 53.88% id in 399 aa, and to Chlamydophila caviae hypothetical protein cca00636 SWALL:Q822P3 (EMBL:AE016996) (411 aa) fasta scores: E(): 2.3e-53, 38.1% id in 391 aa, and to Chlamydophila caviae hypothetical protein cca00639 SWALL:Q822P0 (EMBL:AE016996) (556 aa) fasta scores: E(): 3.9e-35, 35.33% id in 300 aa. This CDS carries a premature stop codon following residue 107.;conserved transmembrane protein (pseudogene) 218497002771 2 probable transmembrane helices predicted for CAB609 by TMHMM2.0 at aa 32-54 and 64-83 218497002772 Protein of unknown function (DUF1389); Region: DUF1389; pfam07146 218497002773 2 probable transmembrane helices predicted for CAB610 by TMHMM2.0 at aa 37-59 and 66-85 218497002774 Protein of unknown function (DUF1389); Region: DUF1389; pfam07146 218497002775 Uncharacterized conserved protein [Function unknown]; Region: COG0327 218497002776 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 218497002777 Pfam match to entry PF01784 DUF34, Domain of unknown function DUF34 , score 270.0, E-value 2e-78 218497002778 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 218497002779 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 218497002780 active site 218497002781 Zn binding site [ion binding]; other site 218497002782 Pfam match to entry PF01432 Peptidase_M3, Peptidase M3 , score 482.7, E-value 1.9e-142 218497002783 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 218497002784 oligomerisation interface [polypeptide binding]; other site 218497002785 mobile loop; other site 218497002786 roof hairpin; other site 218497002787 Pfam match to entry PF00166 cpn10, Chaperonin 10 Kd subunit , score 186.1, E-value 3.7e-53 218497002788 PS00681 Chaperonins cpn10 signature. 218497002789 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 218497002790 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 218497002791 ring oligomerisation interface [polypeptide binding]; other site 218497002792 ATP/Mg binding site [chemical binding]; other site 218497002793 stacking interactions; other site 218497002794 hinge regions; other site 218497002795 Pfam match to entry PF00118 cpn60_TCP1, TCP-1/cpn60 chaperonin family , score 643.7, E-value 6.7e-191 218497002796 PS00296 Chaperonins cpn60 signature. 218497002797 1 probable transmembrane helix predicted for CAB616 by TMHMM2.0 at aa 16-33 218497002798 2 probable transmembrane helices predicted for CAB617 by TMHMM2.0 at aa 31-53 and 58-80 218497002799 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 218497002800 conserved cys residue [active] 218497002801 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 218497002802 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 218497002803 10 probable transmembrane helices predicted for CAB620 by TMHMM2.0 at aa 13-32, 47-64, 77-99, 103-125, 130-152, 162-184, 205-227, 242-264, 271-293 and 303-321 218497002804 Pfam match to entry PF00892 DUF6, Integral membrane protein DUF6 , score 22.2, E-value 0.00082 218497002805 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 218497002806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218497002807 Walker A motif; other site 218497002808 ATP binding site [chemical binding]; other site 218497002809 Walker B motif; other site 218497002810 Family description; Region: UvrD_C_2; pfam13538 218497002811 PS00017 ATP/GTP-binding site motif A (P-loop). 218497002812 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 218497002813 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 218497002814 active site 218497002815 HIGH motif; other site 218497002816 KMSKS motif; other site 218497002817 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 218497002818 tRNA binding surface [nucleotide binding]; other site 218497002819 anticodon binding site; other site 218497002820 Pfam match to entry PF00133 tRNA-synt_1, tRNA synthetases class I (I, L, M and V) , score -100.4, E-value 5.8e-14 218497002821 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 218497002822 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 218497002823 catalytic site [active] 218497002824 G-X2-G-X-G-K; other site 218497002825 Pfam match to entry PF00625 Guanylate_kin, Guanylate kinase , score 108.8, E-value 6.7e-30 218497002826 PS00856 Guanylate kinase signature. 218497002827 PS00017 ATP/GTP-binding site motif A (P-loop). 218497002828 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 218497002829 RNA/DNA hybrid binding site [nucleotide binding]; other site 218497002830 active site 218497002831 Pfam match to entry PF01351 RNase_HII, Ribonuclease HII , score 223.2, E-value 2.4e-64 218497002832 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 218497002833 Pfam match to entry PF01245 Ribosomal_L19, Ribosomal protein L19 , score 148.6, E-value 7.2e-42 218497002834 tRNA (guanine-N(1)-)-methyltransferase/unknown domain fusion protein; Reviewed; Region: trmD; PRK01037 218497002835 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 218497002836 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 218497002837 active site 218497002838 Pfam match to entry PF01746 tRNA_m1G_MT, tRNA (Guanine-1)-methyltransferase , score 316.3, E-value 2.3e-92 218497002839 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14522 218497002840 signal recognition particle protein; Provisional; Region: PRK10867 218497002841 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 218497002842 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 218497002843 P loop; other site 218497002844 GTP binding site [chemical binding]; other site 218497002845 Signal peptide binding domain; Region: SRP_SPB; pfam02978 218497002846 Pfam match to entry PF02978 SRP_SPB, Signal peptide binding domain , score 160.6, E-value 1.8e-45 218497002847 Pfam match to entry PF00448 SRP54, SRP54-type protein, GTPase domain , score 347.3, E-value 1.1e-101 218497002848 PS00017 ATP/GTP-binding site motif A (P-loop). 218497002849 Pfam match to entry PF02881 SRP54_N, SRP54-type protein, helical bundle domain , score 117.0, E-value 2.4e-32 218497002850 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 218497002851 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218497002852 S-adenosylmethionine binding site [chemical binding]; other site 218497002853 peptide chain release factor 1; Validated; Region: prfA; PRK00591 218497002854 PCRF domain; Region: PCRF; pfam03462 218497002855 RF-1 domain; Region: RF-1; pfam00472 218497002856 Pfam match to entry PF00472 RF-1, Peptidyl-tRNA hydrolase domain , score 262.4, E-value 4e-76 218497002857 PS00745 Prokaryotic-type class I peptide chain release factors signature. 218497002858 Pfam match to entry PF03462 PCRF, PCRF domain , score 201.8, E-value 7.1e-58 218497002859 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 218497002860 Pfam match to entry PF01197 Ribosomal_L31, Ribosomal protein L31 , score 50.0, E-value 3.3e-12 218497002861 PS01143 Ribosomal protein L31 signature. 218497002862 Signal peptide predicted for CAB632 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.984 between residues 30 and 31 218497002863 9 x poly A tract 218497002864 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 218497002865 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 218497002866 Catalytic site [active] 218497002867 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 218497002868 Pfam match to entry PF00461 Peptidase_S26, Signal peptidase I , score 17.1, E-value 4.5e-06 218497002869 PS00761 Signal peptidases I signature 3. 218497002870 1 probable transmembrane helix predicted for CAB633 by TMHMM2.0 at aa 609-631 218497002871 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 218497002872 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 218497002873 HIGH motif; other site 218497002874 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 218497002875 active site 218497002876 KMSKS motif; other site 218497002877 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 218497002878 tRNA binding surface [nucleotide binding]; other site 218497002879 anticodon binding site; other site 218497002880 Pfam match to entry PF00133 tRNA-synt_1, tRNA synthetases class I (I, L, M and V) , score 835.7, E-value 1e-248 218497002881 PS00017 ATP/GTP-binding site motif A (P-loop). 218497002882 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 218497002883 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 218497002884 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 218497002885 putative active site [active] 218497002886 PhoH-like protein; Region: PhoH; pfam02562 218497002887 Pfam match to entry PF02562 PhoH, PhoH-like protein , score -70.8, E-value 1.8e-10 218497002888 PS00017 ATP/GTP-binding site motif A (P-loop). 218497002889 Pfam match to entry PF01850 PIN, PIN domain , score 16.9, E-value 8.4e-05 218497002890 Bacterial SH3 domain homologues; Region: SH3b; smart00287 218497002891 Bacterial SH3 domain homologues; Region: SH3b; smart00287 218497002892 Signal peptide predicted for CAB638 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 24 and 25 218497002893 BNR repeat-like domain; Region: BNR_2; pfam13088 218497002894 Pfam match to entry PF02012 BNR, BNR/Asp-box repeat , score 9.5, E-value 2.1 218497002895 Pfam match to entry PF02012 BNR, BNR/Asp-box repeat , score 12.6, E-value 0.62 218497002896 Pfam match to entry PF02012 BNR, BNR/Asp-box repeat , score 1.4, E-value 28 218497002897 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 218497002898 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 218497002899 Pfam match to entry PF02322 Cyto_ox_2, Cytochrome oxidase subunit II , score 496.0, E-value 1.9e-146 218497002900 7 probable transmembrane helices predicted for CAB640 by TMHMM2.0 at aa 79-101, 122-144, 159-181, 202-224, 239-258, 278-300 and 320-342 218497002901 Signal peptide predicted for CAB640 by SignalP 2.0 HMM (Signal peptide probabilty 0.767) with cleavage site probability 0.702 between residues 23 and 24 218497002902 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 218497002903 Pfam match to entry PF01654 Bac_Ubq_Cox, Bacterial Cytochrome Ubiquinol Oxidase , score 430.9, E-value 7.7e-127 218497002904 9 probable transmembrane helices predicted for CAB641 by TMHMM2.0 at aa 20-42, 55-77, 97-119, 131-153, 189-211, 223-242, 324-346, 359-381 and 409-431 218497002905 Uncharacterized conserved protein [Function unknown]; Region: COG1624 218497002906 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 218497002907 3 probable transmembrane helices predicted for CAB642 by TMHMM2.0 at aa 5-24, 37-59 and 64-86 218497002908 Pfam match to entry PF02457 DUF147, Domain of unknown function DUF147 , score 225.4, E-value 5.6e-65 218497002909 1 probable transmembrane helix predicted for CAB643 by TMHMM2.0 at aa 22-41 218497002910 lipid A biosynthesis lauroyl acyltransferase; Provisional; Region: PRK05906 218497002911 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 218497002912 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 218497002913 putative acyl-acceptor binding pocket; other site 218497002914 Pfam match to entry PF03279 Lip_A_acyltrans, Bacterial lipid A biosynthesis acyltransferase , score 362.8, E-value 2.4e-106 218497002915 pyruvate kinase; Provisional; Region: PRK05826 218497002916 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 218497002917 domain interfaces; other site 218497002918 active site 218497002919 Pfam match to entry PF02887 PK_C, Pyruvate kinase, alpha/beta domain , score 54.8, E-value 1.2e-13 218497002920 Pfam match to entry PF00224 PK, Pyruvate kinase, barrel domain , score 410.3, E-value 1.2e-120 218497002921 excinuclease ABC subunit A; Provisional; Region: PRK00635 218497002922 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218497002923 Walker A/P-loop; other site 218497002924 ATP binding site [chemical binding]; other site 218497002925 Q-loop/lid; other site 218497002926 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 218497002927 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 218497002928 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218497002929 Walker A/P-loop; other site 218497002930 ATP binding site [chemical binding]; other site 218497002931 Q-loop/lid; other site 218497002932 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218497002933 ATP binding site [chemical binding]; other site 218497002934 Q-loop/lid; other site 218497002935 ABC transporter signature motif; other site 218497002936 Walker B; other site 218497002937 D-loop; other site 218497002938 H-loop/switch region; other site 218497002939 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 218497002940 Walker A/P-loop; other site 218497002941 ATP binding site [chemical binding]; other site 218497002942 Q-loop/lid; other site 218497002943 ABC transporter signature motif; other site 218497002944 Walker B; other site 218497002945 D-loop; other site 218497002946 H-loop/switch region; other site 218497002947 Pfam match to entry PF00005 ABC_tran, ABC transporter , score 27.4, E-value 2.9e-08 218497002948 PS00017 ATP/GTP-binding site motif A (P-loop). 218497002949 PS00017 ATP/GTP-binding site motif A (P-loop). 218497002950 Pfam match to entry PF00005 ABC_tran, ABC transporter , score 57.5, E-value 1.9e-14 218497002951 PS00017 ATP/GTP-binding site motif A (P-loop). 218497002952 PS00190 Cytochrome c family heme-binding site signature. 218497002953 Pfam match to entry PF00005 ABC_tran, ABC transporter , score 33.3, E-value 1.1e-08 218497002954 PS00017 ATP/GTP-binding site motif A (P-loop). 218497002955 serine/threonine-protein kinase; Reviewed; Region: pknD; PRK13184 218497002956 Catalytic domain of Protein Kinases; Region: PKc; cd00180 218497002957 active site 218497002958 ATP binding site [chemical binding]; other site 218497002959 substrate binding site [chemical binding]; other site 218497002960 activation loop (A-loop); other site 218497002961 Pfam match to entry PF00069 pkinase, Protein kinase domain , score 142.7, E-value 4.4e-40 218497002962 PS00108 Serine/Threonine protein kinases active-site signature. 218497002963 PS00107 Protein kinases ATP-binding region signature. 218497002964 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 218497002965 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 218497002966 active site 218497002967 HIGH motif; other site 218497002968 nucleotide binding site [chemical binding]; other site 218497002969 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 218497002970 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 218497002971 active site 218497002972 KMSKS motif; other site 218497002973 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 218497002974 tRNA binding surface [nucleotide binding]; other site 218497002975 anticodon binding site; other site 218497002976 Pfam match to entry PF00133 tRNA-synt_1, tRNA synthetases class I (I, L, M and V) , score 690.9, E-value 4.1e-205 218497002977 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 218497002978 Signal peptide predicted for CAB649 by SignalP 2.0 HMM (Signal peptide probabilty 0.928) with cleavage site probability 0.765 between residues 38 and 39 218497002979 V-type ATP synthase subunit K; Provisional; Region: PRK09621 218497002980 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 218497002981 3 probable transmembrane helices predicted for CAB650 by TMHMM2.0 at aa 33-55, 65-87 and 108-127 218497002982 Signal peptide predicted for CAB650 by SignalP 2.0 HMM (Signal peptide probabilty 0.950) with cleavage site probability 0.728 between residues 21 and 22 218497002983 V-type ATP synthase subunit I; Validated; Region: PRK05771 218497002984 Pfam match to entry PF01496 V_ATPase_sub_a, V-type ATPase 116kDa subunit family , score -105.0, E-value 9.3e-10 218497002985 7 probable transmembrane helices predicted for CAB651 by TMHMM2.0 at aa 317-339, 360-382, 457-479, 486-508, 518-540, 561-583 and 593-615 218497002986 V-type ATP synthase subunit D; Provisional; Region: PRK02195 218497002987 Pfam match to entry PF01813 ATP-synt_D, ATP synthase subunit D , score 155.5, E-value 6e-44 218497002988 V-type ATP synthase subunit B; Provisional; Region: PRK02118 218497002989 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 218497002990 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 218497002991 Walker A motif homologous position; other site 218497002992 Walker B motif; other site 218497002993 Pfam match to entry PF00006 ATP-synt_ab, ATP synthase alpha/beta family, nucleotide-binding domain , score 283.7, E-value 1.5e-82 218497002994 Pfam match to entry PF02874 ATP-synt_ab_N, ATP synthase alpha/beta family, beta-barrel domain , score 58.3, E-value 1.1e-14 218497002995 V-type ATP synthase subunit A; Provisional; Region: PRK04192 218497002996 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 218497002997 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 218497002998 Walker A motif/ATP binding site; other site 218497002999 Walker B motif; other site 218497003000 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 218497003001 Pfam match to entry PF00306 ATP-synt_ab_C, ATP synthase alpha/beta chain, C terminal domain , score 35.0, E-value 1.1e-07 218497003002 Pfam match to entry PF00006 ATP-synt_ab, ATP synthase alpha/beta family, nucleotide-binding domain , score 496.1, E-value 1.7e-146 218497003003 PS00152 ATP synthase alpha and beta subunits signature. 218497003004 PS00017 ATP/GTP-binding site motif A (P-loop). 218497003005 Pfam match to entry PF02874 ATP-synt_ab_N, ATP synthase alpha/beta family, beta-barrel domain , score 42.5, E-value 6.4e-10 218497003006 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 218497003007 V-type ATP synthase subunit E; Provisional; Region: PRK01005 218497003008 V-type ATP synthase subunit E; Provisional; Region: PRK01558 218497003009 transaldolase-like protein; Provisional; Region: PTZ00411 218497003010 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 218497003011 active site 218497003012 dimer interface [polypeptide binding]; other site 218497003013 catalytic residue [active] 218497003014 Pfam match to entry PF00923 Transaldolase, Transaldolase , score 409.8, E-value 1.6e-120 218497003015 PS00958 Transaldolase active site. 218497003016 PS01054 Transaldolase signature 1. 218497003017 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 218497003018 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 218497003019 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 218497003020 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 218497003021 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 218497003022 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 218497003023 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 218497003024 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 218497003025 DNA binding site [nucleotide binding] 218497003026 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 218497003027 Pfam match to entry PF01854 RNA_pol_A2, RNA polymerase A/beta'/A subunit , score 21.5, E-value 1.8e-06 218497003028 Pfam match to entry PF01854 RNA_pol_A2, RNA polymerase A/beta'/A subunit , score 40.1, E-value 8.5e-12 218497003029 Pfam match to entry PF00623 RNA_pol_A, RNA polymerase alpha subunit , score 932.9, E-value 5.7e-278 218497003030 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 218497003031 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 218497003032 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 218497003033 DNA-directed RNA polymerase, beta subunit; Region: rpoB; TIGR02013 218497003034 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 218497003035 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 218497003036 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 218497003037 RPB3 interaction site [polypeptide binding]; other site 218497003038 RPB1 interaction site [polypeptide binding]; other site 218497003039 RPB11 interaction site [polypeptide binding]; other site 218497003040 RPB10 interaction site [polypeptide binding]; other site 218497003041 Pfam match to entry PF00562 RNA_pol_B, RNA polymerase beta subunit , score 1826.4, E-value 0 218497003042 PS00017 ATP/GTP-binding site motif A (P-loop). 218497003043 PS01166 RNA polymerases beta chain signature. 218497003044 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 218497003045 L11 interface [polypeptide binding]; other site 218497003046 putative EF-Tu interaction site [polypeptide binding]; other site 218497003047 putative EF-G interaction site [polypeptide binding]; other site 218497003048 Pfam match to entry PF00542 Ribosomal_L12, Ribosomal protein L7/L12 C-terminal domain , score 136.2, E-value 3.9e-38 218497003049 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 218497003050 23S rRNA interface [nucleotide binding]; other site 218497003051 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 218497003052 Pfam match to entry PF00466 Ribosomal_L10, Ribosomal protein L10 , score 9.0, E-value 7.9e-05 218497003053 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 218497003054 mRNA/rRNA interface [nucleotide binding]; other site 218497003055 Pfam match to entry PF00687 Ribosomal_L1, Ribosomal protein L1p/L10e family , score 355.6, E-value 3.5e-104 218497003056 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 218497003057 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 218497003058 23S rRNA interface [nucleotide binding]; other site 218497003059 L7/L12 interface [polypeptide binding]; other site 218497003060 putative thiostrepton binding site; other site 218497003061 L25 interface [polypeptide binding]; other site 218497003062 Pfam match to entry PF00298 Ribosomal_L11, Ribosomal protein L11, RNA binding domain , score 113.8, E-value 2.1e-31 218497003063 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00359 Ribosomal protein L11 signature. 218497003064 Pfam match to entry PF03946 Ribosomal_L11_N, Ribosomal protein L11, N-terminal domain , score 114.2, E-value 1.6e-31 218497003065 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 218497003066 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 218497003067 putative homodimer interface [polypeptide binding]; other site 218497003068 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 218497003069 heterodimer interface [polypeptide binding]; other site 218497003070 homodimer interface [polypeptide binding]; other site 218497003071 Pfam match to entry PF00467 KOW, KOW motif , score 34.5, E-value 1.6e-07 218497003072 Pfam match to entry PF02357 NusG, Transcription termination factor nusG , score 77.4, E-value 1.9e-20 218497003073 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 218497003074 1 probable transmembrane helix predicted for CAB667 by TMHMM2.0 at aa 45-67 218497003075 elongation factor Tu; Reviewed; Region: PRK12735 218497003076 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 218497003077 G1 box; other site 218497003078 GEF interaction site [polypeptide binding]; other site 218497003079 GTP/Mg2+ binding site [chemical binding]; other site 218497003080 Switch I region; other site 218497003081 G2 box; other site 218497003082 G3 box; other site 218497003083 Switch II region; other site 218497003084 G4 box; other site 218497003085 G5 box; other site 218497003086 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 218497003087 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 218497003088 Antibiotic Binding Site [chemical binding]; other site 218497003089 Pfam match to entry PF03143 GTP_EFTU_D3, Elongation factor Tu C-terminal domain , score 200.0, E-value 2.4e-57 218497003090 Pfam match to entry PF03144 GTP_EFTU_D2, Elongation factor Tu domain 2 , score 113.3, E-value 2.9e-31 218497003091 Pfam match to entry PF00009 GTP_EFTU, Elongation factor Tu GTP binding domain , score 325.0, E-value 5.7e-95 218497003092 PS00301 GTP-binding elongation factors signature. 218497003093 PS00017 ATP/GTP-binding site motif A (P-loop). 218497003094 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 218497003095 rRNA binding site [nucleotide binding]; other site 218497003096 predicted 30S ribosome binding site; other site 218497003097 Pfam match to entry PF00575 S1, S1 RNA binding domain , score 32.4, E-value 6.6e-07 218497003098 3 probable transmembrane helices predicted for CAB670 by TMHMM2.0 at aa 93-110, 115-137 and 168-190 218497003099 Fe-S metabolism associated domain; Region: SufE; cl00951 218497003100 Pfam match to entry PF02657 UPF0050, Domain of unknown function DUF , score 178.7, E-value 6.3e-51 218497003101 BioY family; Region: BioY; pfam02632 218497003102 Pfam match to entry PF02632 BioY, BioY family , score 85.5, E-value 7.1e-23 218497003103 5 probable transmembrane helices predicted for CAB672 by TMHMM2.0 at aa 25-47, 52-74, 89-111, 123-145 and 160-182 218497003104 homopolymeric tract of 12 A residues 218497003105 Protein of unknown function (DUF687); Region: DUF687; pfam05095 218497003106 5 probable transmembrane helices predicted for CAB675 by TMHMM2.0 at aa 344-366, 378-395, 410-432, 470-492 and 538-560 218497003107 11 x poly G tract. Possible site for phase variation 218497003108 dihydrodipicolinate synthase; Region: dapA; TIGR00674 218497003109 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 218497003110 dimer interface [polypeptide binding]; other site 218497003111 active site 218497003112 catalytic residue [active] 218497003113 Pfam match to entry PF00701 DHDPS, Dihydrodipicolinate synthetase , score 103.2, E-value 3.3e-28 218497003114 PS00665 Dihydrodipicolinate synthetase signature 1. 218497003115 aspartate kinase; Provisional; Region: PRK05925 218497003116 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 218497003117 putative catalytic residues [active] 218497003118 nucleotide binding site [chemical binding]; other site 218497003119 aspartate binding site [chemical binding]; other site 218497003120 Pfam match to entry PF00696 aakinase, Amino acid kinase , score 159.5, E-value 3.8e-45 218497003121 PS00324 Aspartokinase signature. 218497003122 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 218497003123 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 218497003124 Pfam match to entry PF02774 Semialdhyde_dhC, Semialdehyde dehydrogenase, dimerisation domain , score 122.7, E-value 4.4e-34 218497003125 Pfam match to entry PF01118 Semialdhyde_dh, Semialdehyde dehydrogenase, NAD binding domain , score 56.3, E-value 4.4e-14 218497003126 dihydrodipicolinate reductase; Provisional; Region: PRK00048 218497003127 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 218497003128 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 218497003129 Pfam match to entry PF01113 DapB, Dihydrodipicolinate reductase , score 39.3, E-value 3.7e-11 218497003130 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 218497003131 cofactor binding site; other site 218497003132 metal binding site [ion binding]; metal-binding site 218497003133 Pfam match to entry PF00351 biopterin_H, Biopterin-dependent aromatic amino acid hydroxylase , score -205.1, E-value 0.0002 218497003134 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 218497003135 Pfam match to entry PF02592 DUF165, Uncharacterized ACR, YhhQ family COG1738 , score 122.5, E-value 5e-34 218497003136 Signal peptide predicted for CAB682 by SignalP 2.0 HMM (Signal peptide probabilty 0.989) with cleavage site probability 0.665 between residues 27 and 28 218497003137 5 probable transmembrane helices predicted for CAB682 by TMHMM2.0 at aa 34-56, 69-91, 106-128, 148-170 and 180-202 218497003138 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784 218497003139 1 probable transmembrane helix predicted for CAB683 by TMHMM2.0 at aa 57-79 218497003140 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 218497003141 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218497003142 NAD(P) binding site [chemical binding]; other site 218497003143 active site 218497003144 Pfam match to entry PF00106 adh_short, short chain dehydrogenase , score 38.8, E-value 8e-10 218497003145 biotin synthase; Region: bioB; TIGR00433 218497003146 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218497003147 FeS/SAM binding site; other site 218497003148 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 218497003149 Pfam match to entry PF01792 Biotin_synth, Biotin synthase , score 623.1, E-value 1.1e-184 218497003150 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 218497003151 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 218497003152 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 218497003153 catalytic residue [active] 218497003154 Pfam match to entry PF00155 aminotran_1_2, Aminotransferase class I and II , score 87.0, E-value 2.5e-23 218497003155 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 218497003156 AAA domain; Region: AAA_26; pfam13500 218497003157 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 218497003158 This hit extended beyond the end of the feature by 1 aa and was clipped.; PS00294 Prenyl group binding site (CAAX box). 218497003159 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 218497003160 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 218497003161 inhibitor-cofactor binding pocket; inhibition site 218497003162 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218497003163 catalytic residue [active] 218497003164 Pfam match to entry PF00202 aminotran_3, Aminotransferase class-III , score 305.3, E-value 4.7e-89 218497003165 PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 218497003166 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 218497003167 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 218497003168 hinge; other site 218497003169 active site 218497003170 Pfam match to entry PF00275 EPSP_syntase, EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) , score 422.4, E-value 2.6e-124 218497003171 PS00885 EPSP synthase signature 2. 218497003172 shikimate kinase; Provisional; Region: PRK00625 218497003173 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 218497003174 ADP binding site [chemical binding]; other site 218497003175 magnesium binding site [ion binding]; other site 218497003176 putative shikimate binding site; other site 218497003177 Pfam match to entry PF01202 SKI, Shikimate kinase , score 44.4, E-value 1.7e-10 218497003178 PS00017 ATP/GTP-binding site motif A (P-loop). 218497003179 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 218497003180 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 218497003181 Tetramer interface [polypeptide binding]; other site 218497003182 active site 218497003183 FMN-binding site [chemical binding]; other site 218497003184 Pfam match to entry PF01264 Chorismate_synt, Chorismate synthase , score 445.2, E-value 3.7e-131 218497003185 PS00787 Chorismate synthase signature 1. 218497003186 PS00788 Chorismate synthase signature 2. 218497003187 PS00789 Chorismate synthase signature 3. 218497003188 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 218497003189 active site 218497003190 dimer interface [polypeptide binding]; other site 218497003191 metal binding site [ion binding]; metal-binding site 218497003192 Pfam match to entry PF01761 DHQ_synthase, 3-dehydroquinate synthase , score 306.8, E-value 1.7e-89 218497003193 bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase protein; Reviewed; Region: aroDE; PRK09310 218497003194 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 218497003195 active site 218497003196 catalytic residue [active] 218497003197 dimer interface [polypeptide binding]; other site 218497003198 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 218497003199 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 218497003200 shikimate binding site; other site 218497003201 NAD(P) binding site [chemical binding]; other site 218497003202 Pfam match to entry PF01487 DHquinase_I, Type I 3-dehydroquinase , score 111.8, E-value 8.4e-31 218497003203 Pfam match to entry PF01488 Shikimate_DH, Shikimate / quinate 5-dehydrogenase , score 170.1, E-value 2.4e-48 218497003204 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 218497003205 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 218497003206 Signal peptide predicted for CAB696 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 1.000 between residues 24 and 25 218497003207 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) [Amino acid transport and metabolism]; Region: COG1945 218497003208 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 218497003209 Signal peptide predicted for CAB698 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.442 between residues 38 and 39 218497003210 Pfam match to entry PF00324 aa_permeases, Amino acid permease , score -209.5, E-value 9.4e-05 218497003211 11 probable transmembrane helices predicted for CAB698 by TMHMM2.0 at aa 39-61, 90-112, 127-149, 156-178, 212-231, 244-266, 292-314, 341-360, 365-387, 408-442 and 462-481 218497003212 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 218497003213 Pfam match to entry PF01266 DAO, FAD dependent oxidoreductase , score 199.9, E-value 2.6e-57 218497003214 6 probable transmembrane helices predicted for CAB700 by TMHMM2.0 at aa 21-40, 55-77, 100-122, 142-164, 194-216 and 236-258 218497003215 malate dehydrogenase; Provisional; Region: PRK05442 218497003216 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 218497003217 NAD(P) binding site [chemical binding]; other site 218497003218 dimer interface [polypeptide binding]; other site 218497003219 malate binding site [chemical binding]; other site 218497003220 Pfam match to entry PF02866 ldh_C, lactate/malate dehydrogenase, alpha/beta C-terminal domain , score 83.8, E-value 2.3e-22 218497003221 Pfam match to entry PF00056 ldh, lactate/malate dehydrogenase, NAD binding domain , score 128.9, E-value 6.1e-36 218497003222 Signal peptide predicted for CAB701 by SignalP 2.0 HMM (Signal peptide probabilty 0.666) with cleavage site probability 0.324 between residues 29 and 30 218497003223 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 218497003224 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 218497003225 active site 218497003226 dimer interface [polypeptide binding]; other site 218497003227 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 218497003228 dimer interface [polypeptide binding]; other site 218497003229 active site 218497003230 Pfam match to entry PF00342 PGI, Phosphoglucose isomerase , score 428.7, E-value 3.3e-126 218497003231 PS00017 ATP/GTP-binding site motif A (P-loop). 218497003232 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 218497003233 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 218497003234 active site 218497003235 DNA binding site [nucleotide binding] 218497003236 Int/Topo IB signature motif; other site 218497003237 Pfam match to entry PF02899 Phage_integr_N, Phage integrase, N-terminal SAM-like domain , score 95.0, E-value 9.4e-26 218497003238 Pfam match to entry PF00589 Phage_integrase, Phage integrase , score 144.0, E-value 1.7e-40 218497003239 Signal peptide predicted for CAB705 by SignalP 2.0 HMM (Signal peptide probability 1.000) with cleavage site probability 0.662 between residues 27 and 28 218497003240 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218497003241 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 218497003242 3 probable transmembrane helices predicted for CAB708 by TMHMM2.0 at aa 342-364, 385-407 and 422-441 218497003243 Predicted helix-turn-helix motif with score 990.000, SD 2.56 at aa 358-379, sequence ESQAKLSQWLGIATATLGILGA 218497003244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 218497003245 S-adenosylmethionine binding site [chemical binding]; other site 218497003246 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 218497003247 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 218497003248 Pfam match to entry PF02401 LYTB, LytB protein , score 541.3, E-value 4.4e-160 218497003249 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 218497003250 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 218497003251 Active site serine [active] 218497003252 PS00037 Myb DNA-binding domain repeat signature 1. 218497003253 Signal peptide predicted for CAB712 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.880 between residues 23 and 24 218497003254 Na+/H+ antiporter, NhaD family; Region: NhaD; TIGR00775 218497003255 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 218497003256 12 probable transmembrane helices predicted for CAB713 by TMHMM2.0 at aa 7-24, 29-46, 53-75, 104-126, 138-157, 177-199, 220-237, 242-264, 285-307, 322-344, 357-379 and 394-413 218497003257 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 218497003258 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 218497003259 Sulfate transporter family; Region: Sulfate_transp; pfam00916 218497003260 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 218497003261 11 probable transmembrane helices predicted for CAB714 by TMHMM2.0 at aa 66-88, 92-111, 113-135, 139-161, 168-185, 211-233, 240-257, 291-313, 326-348, 368-399 and 420-442 218497003262 Pfam match to entry PF00916 Sulfate_transp, Sulfate transporter family , score 224.9, E-value 7.5e-65 218497003263 Pfam match to entry PF01740 STAS, STAS domain , score 84.1, E-value 1.8e-22 218497003264 fumarate hydratase; Reviewed; Region: fumC; PRK00485 218497003265 Class II fumarases; Region: Fumarase_classII; cd01362 218497003266 active site 218497003267 tetramer interface [polypeptide binding]; other site 218497003268 Pfam match to entry PF00206 lyase_1, Lyase , score 546.3, E-value 1.4e-161 218497003269 PS00163 Fumarate lyases signature. 218497003270 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 218497003271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218497003272 dimer interface [polypeptide binding]; other site 218497003273 conserved gate region; other site 218497003274 putative PBP binding loops; other site 218497003275 ABC-ATPase subunit interface; other site 218497003276 NMT1/THI5 like; Region: NMT1; pfam09084 218497003277 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 218497003278 5 probable transmembrane helices predicted for CAB716 by TMHMM2.0 at aa 25-42, 78-100, 112-134, 138-160 and 237-256 218497003279 adenylate kinase; Region: adk; TIGR01351 218497003280 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 218497003281 active site 218497003282 Pfam match to entry PF00406 adenylatekinase, Adenylate kinase , score -42.4, E-value 1.9e-08 218497003283 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 218497003284 Pfam match to entry PF01914 MarC, MarC family integral membrane protein , score -14.4, E-value 2.3e-07 218497003285 5 probable transmembrane helices predicted for CAB718 by TMHMM2.0 at aa 5-27, 48-67, 111-133, 142-164 and 179-201 218497003286 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 218497003287 Pfam match to entry PF01914 MarC, MarC family integral membrane protein , score 183.3, E-value 2.6e-52 218497003288 6 probable transmembrane helices predicted for CAB719 by TMHMM2.0 at aa 2-24, 39-57, 69-91, 106-128, 137-159 and 174-196 218497003289 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218497003290 methionine aminopeptidase; Provisional; Region: PRK12318 218497003291 SEC-C motif; Region: SEC-C; pfam02810 218497003292 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 218497003293 active site 218497003294 Pfam match to entry PF02810 SEC-C, SEC-C motif , score 32.0, E-value 8.9e-07 218497003295 Pfam match to entry PF00557 Peptidase_M24, metallopeptidase M24 , score 227.7, E-value 1.1e-65 218497003296 PS00680 Methionine aminopeptidase subfamily 1 signature. 218497003297 3 probable transmembrane helices predicted for CAB721 by TMHMM2.0 at aa 39-61, 76-98 and 105-127 218497003298 Protein of unknown function (DUF720); Region: DUF720; pfam05302 218497003299 Protein of unknown function (DUF720); Region: DUF720; pfam05302 218497003300 Protein of unknown function (DUF720); Region: DUF720; pfam05302 218497003301 3 probable transmembrane helices predicted for CAB726 by TMHMM2.0 at aa 115-137, 147-165 and 186-208 218497003302 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 218497003303 nucleoside/Zn binding site; other site 218497003304 dimer interface [polypeptide binding]; other site 218497003305 catalytic motif [active] 218497003306 Pfam match to entry PF00383 dCMP_cyt_deam, Cytidine and deoxycytidylate deaminase zinc-binding region , score 122.4, E-value 5.4e-34 218497003307 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 218497003308 16S/18S rRNA binding site [nucleotide binding]; other site 218497003309 S13e-L30e interaction site [polypeptide binding]; other site 218497003310 25S rRNA binding site [nucleotide binding]; other site 218497003311 Pfam match to entry PF00312 Ribosomal_S15, Ribosomal protein S15 , score 102.4, E-value 5.6e-28 218497003312 PS00362 Ribosomal protein S15 signature. 218497003313 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 218497003314 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 218497003315 RNase E interface [polypeptide binding]; other site 218497003316 trimer interface [polypeptide binding]; other site 218497003317 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 218497003318 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 218497003319 RNase E interface [polypeptide binding]; other site 218497003320 trimer interface [polypeptide binding]; other site 218497003321 active site 218497003322 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 218497003323 putative nucleic acid binding region [nucleotide binding]; other site 218497003324 G-X-X-G motif; other site 218497003325 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 218497003326 RNA binding site [nucleotide binding]; other site 218497003327 domain interface; other site 218497003328 Pfam match to entry PF01138 RNase_PH, 3' exoribonuclease, domain 1 , score 100.0, E-value 2.9e-27 218497003329 Pfam match to entry PF03725 RNase_PH_C, 3' exoribonuclease, domain 2 , score 57.9, E-value 1.5e-14 218497003330 Pfam match to entry PF03726 PNPase, Polyribonucleotide nucleotidyltransferase, RNA binding domain , score 10.5, E-value 0.00017 218497003331 Pfam match to entry PF01138 RNase_PH, 3' exoribonuclease, domain 1 , score 157.1, E-value 2e-44 218497003332 Pfam match to entry PF03725 RNase_PH_C, 3' exoribonuclease, domain 2 , score 88.8, E-value 7.2e-24 218497003333 Pfam match to entry PF00013 KH, KH domain , score 40.3, E-value 2.8e-09 218497003334 Pfam match to entry PF00575 S1, S1 RNA binding domain , score 72.5, E-value 5.7e-19 218497003335 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 218497003336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218497003337 Walker A motif; other site 218497003338 ATP binding site [chemical binding]; other site 218497003339 Walker B motif; other site 218497003340 arginine finger; other site 218497003341 Peptidase family M41; Region: Peptidase_M41; pfam01434 218497003342 Pfam match to entry PF01434 Peptidase_M41, Peptidase M41 , score 411.4, E-value 5.4e-121 218497003343 Pfam match to entry PF00004 AAA, ATPase associated with various cellular activities (AAA) , score 312.3, E-value 3.8e-91 218497003344 PS00674 AAA-protein family signature. 218497003345 PS00017 ATP/GTP-binding site motif A (P-loop). 218497003346 Probable transmembrane helices predicted for CAB731 by TMHMM2.0 at aa 372-394 218497003347 Signal peptide predicted for CAB731 by SignalP 2.0 HMM (Signal peptide probabilty 0.971) with cleavage site probability 0.803 between residues 32 and 33 218497003348 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 218497003349 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 218497003350 Ligand Binding Site [chemical binding]; other site 218497003351 Predicted permeases [General function prediction only]; Region: COG0795 218497003352 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 218497003353 Signal peptide predicted for CAB733 by SignalP 2.0 HMM (Signal peptide probabilty 0.872) with cleavage site probability 0.376 between residues 33 and 34 218497003354 Pfam match to entry PF03739 YjgP_YjgQ, Predicted permease YjgP/YjgQ family , score 217.1, E-value 1.7e-62 218497003355 5 probable transmembrane helices predicted for CAB733 by TMHMM2.0 at aa 54-76, 96-118, 277-296, 303-320 and 325-347 218497003356 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 218497003357 Predicted permeases [General function prediction only]; Region: COG0795 218497003358 Signal peptide predicted for CAB734 by SignalP 2.0 HMM (Signal peptide probabilty 0.973) with cleavage site probability 0.373 between residues 45 and 46 218497003359 Pfam match to entry PF03739 YjgP_YjgQ, Predicted permease YjgP/YjgQ family , score 179.4, E-value 3.9e-51 218497003360 5 probable transmembrane helices predicted for CAB734 by TMHMM2.0 at aa 54-76, 97-119, 281-303, 315-337 and 342-364 218497003361 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 218497003362 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 218497003363 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 218497003364 motif 1; other site 218497003365 dimer interface [polypeptide binding]; other site 218497003366 active site 218497003367 motif 2; other site 218497003368 motif 3; other site 218497003369 Pfam match to entry PF01409 tRNA-synt_2d, tRNA synthetases class II core domain (F) , score 403.4, E-value 1.4e-118 218497003370 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218497003371 PS00197 2Fe-2S ferredoxins, iron-sulfur binding region signature. 218497003372 Pfam match to entry PF02912 Phe_tRNA-synt_N, Aminoacyl tRNA synthetase class II, N-terminal domain , score 102.9, E-value 4e-28 218497003373 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 218497003374 23S rRNA binding site [nucleotide binding]; other site 218497003375 L21 binding site [polypeptide binding]; other site 218497003376 L13 binding site [polypeptide binding]; other site 218497003377 Pfam match to entry PF00453 Ribosomal_L20, Ribosomal protein L20 , score 121.0, E-value 1.5e-33 218497003378 PS00937 Ribosomal protein L20 signature. 218497003379 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 218497003380 Pfam match to entry PF01632 Ribosomal_L35p, Ribosomal protein L35 , score 49.9, E-value 3.6e-12 218497003381 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 218497003382 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 218497003383 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 218497003384 Pfam match to entry PF00707 IF3, Translation initiation factor IF-3 , score 357.0, E-value 1.3e-104 218497003385 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 218497003386 putative RNA binding site [nucleotide binding]; other site 218497003387 Pfam match to entry PF01029 NusB, NusB family , score 124.6, E-value 1.2e-34 218497003388 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 218497003389 FAD binding domain; Region: FAD_binding_4; pfam01565 218497003390 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 218497003391 Pfam match to entry PF01565 FAD_binding_4, FAD binding domain , score 27.9, E-value 2e-06 218497003392 Pfam match to entry PF02873 MurB_C, UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain , score 182.0, E-value 6.3e-52 218497003393 Pseudogene. Similar to Oceanobacillus iheyensis hypothetical conserved protein OB2308 SWALL:Q8EP11 (EMBL:AP004600) (191 aa) fasta scores: E(): 2.7e-14, 31.35% id in 185 aa, and to Neisseria meningitidis hypothetical protein NMB0747 SWALL:Q9K071 (EMBL:AE002429) (188 aa) fasta scores: E(): 1.7e-12, 33.51% id in 188 aa. Note contains a frameshift after residue 118;conserved hypothetical protein (pseudogene) 218497003394 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 218497003395 Pfam match to entry PF02390 Methyltransf_4, methyltransferase , score 260.1, E-value 1.9e-75 218497003396 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 218497003397 dimer interface [polypeptide binding]; other site 218497003398 putative radical transfer pathway; other site 218497003399 diiron center [ion binding]; other site 218497003400 tyrosyl radical; other site 218497003401 Pfam match to entry PF00268 ribonuc_red_sm, Ribonucleotide reductase, small chain , score 136.4, E-value 3.3e-38 218497003402 1 probable transmembrane helix predicted for CAB744 by TMHMM2.0 at aa 188-210 218497003403 PS00017 ATP/GTP-binding site motif A (P-loop). 218497003404 ribonucleotide-diphosphate reductase subunit alpha; Provisional; Region: PRK12365 218497003405 ATP cone domain; Region: ATP-cone; pfam03477 218497003406 ATP cone domain; Region: ATP-cone; pfam03477 218497003407 ATP cone domain; Region: ATP-cone; pfam03477 218497003408 Class I ribonucleotide reductase; Region: RNR_I; cd01679 218497003409 active site 218497003410 dimer interface [polypeptide binding]; other site 218497003411 catalytic residues [active] 218497003412 effector binding site; other site 218497003413 R2 peptide binding site; other site 218497003414 Pfam match to entry PF02867 ribonuc_red_lgC, Ribonucleotide reductase, barrel domain , score 598.9, E-value 2e-177 218497003415 PS00185 Isopenicillin N synthetase signature 1. 218497003416 Pfam match to entry PF00317 ribonuc_red_lg, Ribonucleotide reductase, all-alpha domain , score 108.8, E-value 6.7e-30 218497003417 Pfam match to entry PF03477 ATP-cone, ATP cone domain , score 30.8, E-value 2.1e-06 218497003418 Pfam match to entry PF03477 ATP-cone, ATP cone domain , score 91.4, E-value 1.2e-24 218497003419 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 218497003420 Pfam match to entry PF03477 ATP-cone, ATP cone domain , score 104.9, E-value 1e-28 218497003421 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 218497003422 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 218497003423 7 probable transmembrane helices predicted for CAB746 by TMHMM2.0 at aa 15-37, 50-72, 106-128, 148-170, 180-202, 214-235 and 239-261 218497003424 Pfam match to entry PF01066 CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase , score 77.4, E-value 1.9e-20 218497003425 PS00379 CDP-alcohol phosphatidyltransferases signature. 218497003426 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 218497003427 RmuC family; Region: RmuC; pfam02646 218497003428 1 probable transmembrane helix predicted for CAB747 by TMHMM2.0 at aa 26-48 218497003429 Pfam match to entry PF02646 DUF195, Uncharacterized BCR, YigN family, COG1322 , score 575.0, E-value 3.1e-170 218497003430 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 218497003431 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 218497003432 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 218497003433 Peptidase M16C associated; Region: M16C_assoc; pfam08367 218497003434 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 218497003435 Pfam match to entry PF00675 Peptidase_M16, Insulinase (Peptidase M16) , score -21.2, E-value 0.0035 218497003436 hypothetical protein; Provisional; Region: PRK08201 218497003437 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 218497003438 metal binding site [ion binding]; metal-binding site 218497003439 Pfam match to entry PF01546 Peptidase_M20, Peptidase M20/M25/M40 , score 176.4, E-value 2.9e-50 218497003440 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 218497003441 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 218497003442 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 218497003443 protein binding site [polypeptide binding]; other site 218497003444 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 218497003445 protein binding site [polypeptide binding]; other site 218497003446 Pfam match to entry PF00595 PDZ, PDZ domain (Also known as DHR or GLGF) , score 18.1, E-value 0.001 218497003447 Pfam match to entry PF00595 PDZ, PDZ domain (Also known as DHR or GLGF) , score 59.3, E-value 5.5e-15 218497003448 Pfam match to entry PF00089 trypsin, Trypsin , score 75.4, E-value 7.6e-20 218497003449 Signal peptide predicted for CAB750 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.967 between residues 27 and 28 218497003450 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 218497003451 CoA binding domain; Region: CoA_binding; smart00881 218497003452 CoA-ligase; Region: Ligase_CoA; pfam00549 218497003453 Pfam match to entry PF00549 ligase-CoA, CoA-ligase , score 205.6, E-value 4.9e-59 218497003454 PS00399 ATP-citrate lyase / succinyl-CoA ligases family active site. 218497003455 PS01216 ATP-citrate lyase / succinyl-CoA ligases family signature 1. 218497003456 Pfam match to entry PF02629 CoA_binding, CoA binding domain , score 184.4, E-value 1.2e-52 218497003457 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 218497003458 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 218497003459 CoA-ligase; Region: Ligase_CoA; pfam00549 218497003460 Pfam match to entry PF00549 ligase-CoA, CoA-ligase , score 151.5, E-value 9.3e-43 218497003461 PS01217 ATP-citrate lyase / succinyl-CoA ligases family signature 3. 218497003462 Pfam match to entry PF02222 ATP-grasp, ATP-grasp domain , score 123.5, E-value 2.6e-34 218497003463 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 218497003464 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 218497003465 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 218497003466 Pfam match to entry PF00448 SRP54, SRP54-type protein, GTPase domain , score 329.3, E-value 2.8e-96 218497003467 PS00017 ATP/GTP-binding site motif A (P-loop). 218497003468 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 218497003469 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 218497003470 Pfam match to entry PF01027 UPF0005, Uncharacterized protein family UPF0005 , score 29.7, E-value 4.4e-06 218497003471 7 probable transmembrane helices predicted for CAB754 by TMHMM2.0 at aa 22-44, 49-67, 82-101, 108-130, 140-162, 169-191 and 206-228 218497003472 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 218497003473 aromatic amino acid transport protein; Region: araaP; TIGR00837 218497003474 11 probable transmembrane helices predicted for CAB755 by TMHMM2.0 at aa 7-29, 39-61, 82-104, 119-138, 151-173, 188-207, 219-241, 275-297, 309-331, 336-355 and 375-393 218497003475 Pfam match to entry PF03222 Trp_Tyr_perm, Tryptophan/tyrosine permease , score 588.8, E-value 2.2e-174 218497003476 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 218497003477 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 218497003478 glutaminase active site [active] 218497003479 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 218497003480 dimer interface [polypeptide binding]; other site 218497003481 active site 218497003482 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 218497003483 dimer interface [polypeptide binding]; other site 218497003484 active site 218497003485 Pfam match to entry PF01380 SIS, SIS domain , score 62.2, E-value 7e-16 218497003486 Pfam match to entry PF01380 SIS, SIS domain , score 90.4, E-value 2.3e-24 218497003487 Pfam match to entry PF00310 GATase_2, Glutamine amidotransferases class-II , score 222.1, E-value 5.2e-64 218497003488 PS00443 Glutamine amidotransferases class-II active site. 218497003489 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 218497003490 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 218497003491 active site 218497003492 substrate binding site [chemical binding]; other site 218497003493 metal binding site [ion binding]; metal-binding site 218497003494 Pfam match to entry PF00408 PGM_PMM, Phosphoglucomutase/phosphomannomutase, C-terminal domain , score 13.1, E-value 0.0013 218497003495 Pfam match to entry PF02880 PGM_PMM_III, Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III , score 88.4, E-value 9.6e-24 218497003496 Pfam match to entry PF02879 PGM_PMM_II, Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II , score 127.7, E-value 1.4e-35 218497003497 Pfam match to entry PF02878 PGM_PMM_I, Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I , score 207.2, E-value 1.7e-59 218497003498 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 218497003499 poly(A) polymerase; Region: pcnB; TIGR01942 218497003500 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 218497003501 active site 218497003502 NTP binding site [chemical binding]; other site 218497003503 metal binding triad [ion binding]; metal-binding site 218497003504 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 218497003505 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 218497003506 Pfam match to entry PF01743 PolyA_pol, Poly A polymerase , score 222.3, E-value 4.6e-64 218497003507 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK01021 218497003508 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578 218497003509 Predicted membrane protein [Function unknown]; Region: COG3952 218497003510 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 218497003511 6 probable transmembrane helices predicted for CAB759 by TMHMM2.0 at aa 10-32, 44-61, 65-84, 96-118, 138-157 and 170-192 218497003512 Pfam match to entry PF02684 LpxB, Lipid-A-disaccharide synthetase , score 533.9, E-value 7.4e-158 218497003513 IncA protein; Region: IncA; pfam04156 218497003514 2 probable transmembrane helices predicted for CAB760 by TMHMM2.0 at aa 31-53 and 58-80 218497003515 IncA protein; Region: IncA; pfam04156 218497003516 2 probable transmembrane helices predicted for CAB761 by TMHMM2.0 at aa 29-51 and 58-80 218497003517 Similar to Chlamydophila caviae hypothetical protein cca00795 SWALL:Q821Z0 (EMBL:AE016997) (243 aa) fasta scores: E(): 1e-41, 56.79% id in 243 aa. CDS contains coiled coil from residues 107-123 and 150-166. This CDS carries a frameshift mutation following codon 208 and premature stop codon; TMH-family membrane protein (pseudogene) 218497003518 2 probable transmembrane helices predicted for CAB763 by TMHMM2.0 at aa 21-38 and 48-70 218497003519 IncA protein; Region: IncA; pfam04156 218497003520 2 probable transmembrane helices predicted for CAB765 by TMHMM2.0 at aa 218497003521 IncA protein; Region: IncA; pfam04156 218497003522 probable transmembrane helices predicted for CAB767 by TMHMM2.0 at aa and 65-87 218497003523 Signal peptide predicted for CAB766 by SignalP 2.0 HMM (Signal peptide probabilty 0.977) with cleavage site probability 0.874 between residues 52 and 53 218497003524 Similar to Chlamydophila caviae hypothetical protein cca00799 SWALL:Q821Y6 (EMBL:AE016997) (872 aa) fasta scores: E(): 7.2e-75, 43.9% id in 870 aa. Note this CDS contains several premature stop codons;conserved TMH-family membrane protein (pseudogene) 218497003525 probable transmembrane helices predicted for CAB770 by TMHMM2.0 ataa 23-80 218497003526 IncA protein; Region: IncA; pfam04156 218497003527 2 probable transmembrane helices predicted for CAB771 by TMHMM2.0 at aa 44-66 and 71-93 218497003528 IncA protein; Region: IncA; pfam04156 218497003529 2 probable transmembrane helices predicted for CAB772 by TMHMM2.0 at aa 30-52 and 57-79 218497003530 Domain of Unknown Function (DUF1539); Region: DUF1539; pfam07560 218497003531 Domain of Unknown Function (DUF1548); Region: DUF1548; pfam07579 218497003532 1 probable transmembrane helix predicted for CAB773 by TMHMM2.0 at aa 58-80 218497003533 Domain of Unknown Function (DUF1539); Region: DUF1539; pfam07560 218497003534 Domain of Unknown Function (DUF1539); Region: DUF1539; pfam07560 218497003535 Domain of Unknown Function (DUF1548); Region: DUF1548; pfam07579 218497003536 1 probable transmembrane helix predicted for CAB774 by TMHMM2.0 at aa 62-84 218497003537 Domain of Unknown Function (DUF1539); Region: DUF1539; pfam07560 218497003538 Domain of Unknown Function (DUF1548); Region: DUF1548; pfam07579 218497003539 1 probable transmembrane helix predicted for CAB775 by TMHMM2.0 at aa 61-83 218497003540 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218497003541 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 218497003542 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 218497003543 Autotransporter beta-domain; Region: Autotransporter; pfam03797 218497003544 Pfam match to entry PF03797 Autotransporter, Autotransporter beta-domain , score 99.5, E-value 4.4e-27 218497003545 Pfam match to entry PF02415 DUF145, Chlamydia protein of unknown function , score 25.1, E-value 2.3e-07 218497003546 Pfam match to entry PF02415 DUF145, Chlamydia protein of unknown function , score 16.9, E-value 4.6e-05 218497003547 Pfam match to entry PF02415 DUF145, Chlamydia protein of unknown function , score 16.4, E-value 6.3e-05 218497003548 Pfam match to entry PF02415 DUF145, Chlamydia protein of unknown function , score 22.3, E-value 1.4e-06 218497003549 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 218497003550 PS00017 ATP/GTP-binding site motif A (P-loop). 218497003551 putative glycerol-3-phosphate acyltransferase PlsX; Provisional; Region: PRK13846 218497003552 Pfam match to entry PF02504 FA_synthesis, Fatty acid synthesis protein , score 504.4, E-value 5.6e-149 218497003553 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 218497003554 Pfam match to entry PF01783 Ribosomal_L32p, Ribosomal L32p protein family , score 76.4, E-value 4e-20 218497003555 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 218497003556 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 218497003557 homodimer interface [polypeptide binding]; other site 218497003558 oligonucleotide binding site [chemical binding]; other site 218497003559 Pfam match to entry PF00575 S1, S1 RNA binding domain , score 18.8, E-value 8.8e-05 218497003560 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT; Region: LPLAT_GPAT; cd07985 218497003561 putative G3P-binding pocket; other site 218497003562 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 218497003563 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 218497003564 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 218497003565 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 218497003566 Signal peptide predicted for CAB782 by SignalP 2.0 HMM (Signal peptide probabilty 0.984) with cleavage site probability 0.381 between residues 20 and 21 218497003567 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218497003568 Pfam match to entry PF00675 Peptidase_M16, Insulinase (Peptidase M16) , score 77.3, E-value 2.1e-20 218497003569 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 218497003570 11 probable transmembrane helices predicted for CAB783 by TMHMM2.0 at aa 20-39, 68-90, 105-124, 145-167, 187-209, 230-249, 274-305, 318-337, 352-374, 386-408 and 423-445 218497003571 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK00650 218497003572 Pfam match to entry PF00288 GHMP_kinases, GHMP kinases ATP-binding protein , score 68.6, E-value 8.6e-18 218497003573 PS00477 Alpha-2-macroglobulin family thiolester region signature. 218497003574 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 218497003575 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 218497003576 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 218497003577 Pfam match to entry PF03948 Ribosomal_L9_C, Ribosomal protein L9, C-terminal domain , score 25.3, E-value 7.5e-06 218497003578 Pfam match to entry PF01281 Ribosomal_L9_N, Ribosomal protein L9, N-terminal domain , score 56.5, E-value 3.8e-14 218497003579 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 218497003580 Pfam match to entry PF01084 Ribosomal_S18, Ribosomal protein S18 , score 102.5, E-value 5.4e-28 218497003581 PS00057 Ribosomal protein S18 signature. 218497003582 Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Region: RpsF; COG0360 218497003583 Pfam match to entry PF01250 Ribosomal_S6, Ribosomal protein S6 , score 67.3, E-value 2e-17 218497003584 1 probable transmembrane helix predicted for CAB787 by TMHMM2.0 at aa 64-81 218497003585 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 218497003586 putative active site [active] 218497003587 catalytic residue [active] 218497003588 Pfam match to entry PF01195 Pept_tRNA_hydro, Peptidyl-tRNA hydrolase , score 203.1, E-value 2.9e-58 218497003589 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 218497003590 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 218497003591 5S rRNA interface [nucleotide binding]; other site 218497003592 CTC domain interface [polypeptide binding]; other site 218497003593 L16 interface [polypeptide binding]; other site 218497003594 Pfam match to entry PF01386 Ribosomal_L25p, Ribosomal L25p family , score 40.6, E-value 2.3e-09 218497003595 glycogen synthase; Provisional; Region: glgA; PRK00654 218497003596 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 218497003597 ADP-binding pocket [chemical binding]; other site 218497003598 homodimer interface [polypeptide binding]; other site 218497003599 Pfam match to entry PF00534 Glycos_transf_1, Glycosyl transferases group 1 , score 13.0, E-value 5.8e-06 218497003600 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 218497003601 Pfam match to entry PF01066 CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase , score 109.4, E-value 4.4e-30 218497003602 4 probable transmembrane helices predicted for CAB791 by TMHMM2.0 at aa 27-49, 80-102, 132-154 and 161-183 218497003603 PS00379 CDP-alcohol phosphatidyltransferases signature. 218497003604 glycyl-tRNA synthetase; Provisional; Region: PRK14908 218497003605 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 218497003606 dimer interface [polypeptide binding]; other site 218497003607 motif 1; other site 218497003608 active site 218497003609 motif 2; other site 218497003610 motif 3; other site 218497003611 Pfam match to entry PF02091 tRNA_synt_2e, Glycyl-tRNA synthetase alpha subunit , score 759.9, E-value 6.7e-226 218497003612 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218497003613 Pfam match to entry PF02092 tRNA_synt_2f, Glycyl-tRNA synthetase beta subunit , score 953.4, E-value 3.8e-284 218497003614 Signal peptide predicted for CAB794 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.977 between residues 18 and 19 218497003615 Signal peptide predicted for CAB796 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.998 between residues 25 and 26 218497003616 DNA primase; Validated; Region: dnaG; PRK05667 218497003617 CHC2 zinc finger; Region: zf-CHC2; pfam01807 218497003618 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 218497003619 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 218497003620 active site 218497003621 metal binding site [ion binding]; metal-binding site 218497003622 interdomain interaction site; other site 218497003623 Pfam match to entry PF01751 Toprim, Toprim domain , score 49.7, E-value 4.3e-12 218497003624 Pfam match to entry PF01807 zf-CHC2, CHC2 zinc finger , score 178.6, E-value 6.5e-51 218497003625 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 218497003626 MutS domain I; Region: MutS_I; pfam01624 218497003627 MutS domain II; Region: MutS_II; pfam05188 218497003628 MutS domain III; Region: MutS_III; pfam05192 218497003629 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 218497003630 Walker A/P-loop; other site 218497003631 ATP binding site [chemical binding]; other site 218497003632 Q-loop/lid; other site 218497003633 ABC transporter signature motif; other site 218497003634 Walker B; other site 218497003635 D-loop; other site 218497003636 H-loop/switch region; other site 218497003637 Pfam match to entry PF01624 MutS_N, MutS family, N-terminal DNA binding domain , score 661.2, E-value 3.6e-196 218497003638 PS00017 ATP/GTP-binding site motif A (P-loop). 218497003639 Pfam match to entry PF00488 MutS_C, DNA mismatch repair proteins, mutS family , score 434.4, E-value 6.4e-128 218497003640 PS00017 ATP/GTP-binding site motif A (P-loop). 218497003641 PS00486 DNA mismatch repair proteins mutS family signature. 218497003642 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 218497003643 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 218497003644 GIY-YIG motif/motif A; other site 218497003645 active site 218497003646 catalytic site [active] 218497003647 putative DNA binding site [nucleotide binding]; other site 218497003648 metal binding site [ion binding]; metal-binding site 218497003649 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 218497003650 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 218497003651 Pfam match to entry PF01541 Exci_endo_N, Endo/excinuclease amino terminal domain , score 125.7, E-value 5.5e-35 218497003652 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 218497003653 Pfam match to entry PF03780 DUF322, Protein of unknown function (DUF322) , score 146.8, E-value 2.5e-41 218497003654 2 probable transmembrane helices predicted for CAB801 by TMHMM2.0 at aa 4-22 and 29-48 218497003655 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 218497003656 Pfam match to entry PF00253 Ribosomal_S14, Ribosomal protein S14p/S29e , score 138.6, E-value 7.1e-39 218497003657 PS00527 Ribosomal protein S14 signature. 218497003658 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 218497003659 Pfam match to entry PF00444 Ribosomal_L36, Ribosomal protein L36 , score 21.4, E-value 5.5e-07 218497003660 ribonuclease P; Reviewed; Region: rnpA; PRK00730 218497003661 Pfam match to entry PF00825 Ribonuclease_P, Ribonuclease P , score 51.7, E-value 1e-12 218497003662 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 218497003663 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 218497003664 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 218497003665 active site 218497003666 HIGH motif; other site 218497003667 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 218497003668 KMSKS motif; other site 218497003669 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 218497003670 Pfam match to entry PF01406 tRNA-synt_1e, tRNA synthetases class I (C) , score 498.8, E-value 2.7e-147 218497003671 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 218497003672 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 218497003673 dimer interface [polypeptide binding]; other site 218497003674 putative anticodon binding site; other site 218497003675 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 218497003676 motif 1; other site 218497003677 dimer interface [polypeptide binding]; other site 218497003678 active site 218497003679 motif 2; other site 218497003680 motif 3; other site 218497003681 Pfam match to entry PF00152 tRNA-synt_2, tRNA synthetases class II (D, K and N) , score 396.3, E-value 2e-116 218497003682 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218497003683 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 218497003684 Pfam match to entry PF01336 tRNA_anti, OB-fold nucleic acid binding domain , score 56.9, E-value 2.9e-14 218497003685 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 218497003686 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 218497003687 Signal peptide predicted for CAB808 by SignalP 2.0 HMM (Signal peptide probabilty 0.977) with cleavage site probability 0.785 between residues 24 and 25 218497003688 primosome assembly protein PriA; Validated; Region: PRK05580 218497003689 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218497003690 ATP binding site [chemical binding]; other site 218497003691 putative Mg++ binding site [ion binding]; other site 218497003692 helicase superfamily c-terminal domain; Region: HELICc; smart00490 218497003693 ATP-binding site [chemical binding]; other site 218497003694 Predicted helix-turn-helix motif with score 1236.000, SD 3.40 at aa 160-181, sequence PGLSELMDKAKVSQSPIHSLEK 218497003695 PS00017 ATP/GTP-binding site motif A (P-loop). 218497003696 Pfam match to entry PF00271 helicase_C, Helicase conserved C-terminal domain , score 24.8, E-value 0.00011 218497003697 8-amino-7-oxononanoate synthase; Provisional; Region: PRK05937 218497003698 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 218497003699 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 218497003700 catalytic residue [active] 218497003701 Pfam match to entry PF00155 aminotran_1_2, Aminotransferase class I and II , score 31.6, E-value 2e-08 218497003702 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 218497003703 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 218497003704 long chain fatty acid--[acyl-carrier-protein] ligase; Validated; Region: PRK06334 218497003705 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 218497003706 acyl-activating enzyme (AAE) consensus motif; other site 218497003707 AMP binding site [chemical binding]; other site 218497003708 active site 218497003709 CoA binding site [chemical binding]; other site 218497003710 Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme , score 255.4, E-value 5e-74 218497003711 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 218497003712 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 218497003713 putative acyl-acceptor binding pocket; other site 218497003714 Pfam match to entry PF01553 Acyltransferase, Acyltransferase , score 27.1, E-value 6.5e-08 218497003715 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 218497003716 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 218497003717 active site 218497003718 putative lithium-binding site [ion binding]; other site 218497003719 substrate binding site [chemical binding]; other site 218497003720 Pfam match to entry PF00459 inositol_P, Inositol monophosphatase , score 173.4, E-value 2.4e-49 218497003721 PS00629 Inositol monophosphatase signature 1. 218497003722 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 218497003723 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 218497003724 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 218497003725 NAD binding site [chemical binding]; other site 218497003726 Phe binding site; other site 218497003727 Pfam match to entry PF00208 GLFV_dehydrog, Glutamate/Leucine/Phenylalanine/Valine dehydrogenase , score 129.0, E-value 5.8e-36 218497003728 Pfam match to entry PF02812 GLFV_dehydrog_N, Glu/Leu/Phe/Val dehydrogenase, dimerisation domain , score 70.4, E-value 2.5e-18 218497003729 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 218497003730 dimer interface [polypeptide binding]; other site 218497003731 substrate binding site [chemical binding]; other site 218497003732 metal binding sites [ion binding]; metal-binding site 218497003733 Pfam match to entry PF00719 Pyrophosphatase, Inorganic pyrophosphatase , score 82.8, E-value 4.4e-22 218497003734 PS00387 Inorganic pyrophosphatase signature. 218497003735 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 218497003736 active site 218497003737 Ap4A binding cleft/pocket [chemical binding]; other site 218497003738 P4 phosphate binding site; other site 218497003739 nudix motif; other site 218497003740 putative P2/P3 phosphate binding site [ion binding]; other site 218497003741 Pfam match to entry PF00293 NUDIX, NUDIX domain , score 75.8, E-value 5.8e-20 218497003742 PS00893 mutT domain signature. 218497003743 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 218497003744 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 218497003745 dimer interface [polypeptide binding]; other site 218497003746 active site 218497003747 Pfam match to entry PF02801 ketoacyl-synt_C, Beta-ketoacyl synthase, C-terminal domain , score 234.0, E-value 1.4e-67 218497003748 Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase, N-terminal domain , score 287.0, E-value 1.6e-83 218497003749 PS00606 Beta-ketoacyl synthases active site. 218497003750 PS00205 Transferrins signature 1. 218497003751 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 218497003752 Pfam match to entry PF02410 DUF143, Domain of unknown function DUF143 , score 176.0, E-value 4.1e-50 218497003753 Similar to Chlamydophila caviae hypothetical protein CCA00855 SWALL:Q821T1 (EMBL:AE016997) (213 aa) fasta scores: E(): 3.8e-53, 80.81% id in 172 aa, and to Chlamydia pneumoniae hypothetical protein CPN0914 SWALL:Q9Z6Z2 (EMBL:AE001671) (133 aa) fasta scores: E(): 1.7e-31, 65.9% id in 132 aa. Note this CDS has a frame shift mutation within a 10x'T' homopolymeric tract. This may indicate that the expression of the product of this CDS is subject to phase variation. Only significant full-length database matches are to Chlamydiaceae proteins.;conserved hypothetical protein (pseudogene) 218497003754 homopolymeric tract of 10xT residues. This is also the site of a frame shift in CAB820 which suggests that the protein product of this CDS is sunbject to phase variation 218497003755 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 218497003756 hypothetical protein; Provisional; Region: PRK05927 218497003757 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218497003758 FeS/SAM binding site; other site 218497003759 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 218497003760 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 218497003761 Pfam match to entry PF01715 IPPT, IPP transferase , score 227.7, E-value 1.1e-65 218497003762 PS00017 ATP/GTP-binding site motif A (P-loop). 218497003763 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 218497003764 anti sigma factor interaction site; other site 218497003765 regulatory phosphorylation site [posttranslational modification]; other site 218497003766 Pfam match to entry PF01740 STAS, STAS domain , score 79.8, E-value 3.8e-21 218497003767 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 218497003768 Pfam match to entry PF03091 CutA1, CutA1 divalent ion tolerance protein , score 156.1, E-value 4.1e-44 218497003769 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 218497003770 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cd02409 218497003771 G-X-X-G motif; other site 218497003772 Pfam match to entry PF00013 KH, KH domain , score 12.5, E-value 0.0091 218497003773 bifunctional D-alanyl-alanine synthetase A/UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: PRK14573 218497003774 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 218497003775 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 218497003776 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 218497003777 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 218497003778 ATP-grasp domain; Region: ATP-grasp_4; cl17255 218497003779 Pfam match to entry PF01820 Dala_Dala_ligas, D-ala D-ala ligase , score 397.2, E-value 1.1e-116 218497003780 PS00843 D-alanine--D-alanine ligase signature 1. 218497003781 PS00017 ATP/GTP-binding site motif A (P-loop). 218497003782 Pfam match to entry PF02875 Mur_ligase_C, Mur ligase, glutamate ligase domain , score 85.1, E-value 9.1e-23 218497003783 Pfam match to entry PF01225 Mur_ligase, Mur ligase, catalytic domain , score 152.0, E-value 6.6e-43 218497003784 1 probable transmembrane helix predicted for CAB829 by TMHMM2.0 at aa 5-24 218497003785 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 218497003786 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 218497003787 active site 218497003788 homodimer interface [polypeptide binding]; other site 218497003789 Pfam match to entry PF03033 Glyco_transf_28, Glycosyltransferase 28 N-terminal domain , score 320.5, E-value 1.3e-93 218497003790 cell division protein FtsW; Region: ftsW; TIGR02614 218497003791 Pfam match to entry PF01098 FTSW_RODA_SPOVE, Cell cycle protein , score 260.6, E-value 1.3e-75 218497003792 8 probable transmembrane helices predicted for CAB831 by TMHMM2.0 at aa 41-63, 73-92, 137-154, 159-176, 181-203, 267-289, 301-323 and 333-355 218497003793 Signal peptide predicted for CAB831 by SignalP 2.0 HMM (Signal peptide probabilty 0.982) with cleavage site probability 0.545 between residues 25 and 26 218497003794 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 218497003795 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 218497003796 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 218497003797 Pfam match to entry PF01476 LysM, LysM domain , score 48.5, E-value 9.8e-12 218497003798 Pfam match to entry PF01476 LysM, LysM domain , score 61.6, E-value 1.1e-15 218497003799 Signal peptide predicted for CAB832 by SignalP 2.0 HMM (Signal peptide probabilty 0.832) with cleavage site probability 0.780 between residues 28 and 29 218497003800 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00683 218497003801 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 218497003802 NAD(P) binding site [chemical binding]; other site 218497003803 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 218497003804 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 218497003805 Pfam match to entry PF02875 Mur_ligase_C, Mur ligase, glutamate ligase domain , score 47.5, E-value 2e-11 218497003806 Pfam match to entry PF01225 Mur_ligase, Mur ligase, catalytic domain , score 52.3, E-value 2e-15 218497003807 PS00017 ATP/GTP-binding site motif A (P-loop). 218497003808 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 218497003809 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 218497003810 Mg++ binding site [ion binding]; other site 218497003811 putative catalytic motif [active] 218497003812 putative substrate binding site [chemical binding]; other site 218497003813 9 probable transmembrane helices predicted for CAB834 by TMHMM2.0 at aa 10-29, 67-86, 90-107, 127-149, 169-191, 198-220, 248-270, 275-297 and 329-346 218497003814 Pfam match to entry PF00953 Glycos_transf_4, Glycosyl transferase , score 153.2, E-value 3e-43 218497003815 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 218497003816 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 218497003817 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 218497003818 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 218497003819 Pfam match to entry PF02875 Mur_ligase_C, Mur ligase, glutamate ligase domain , score 28.9, E-value 7.9e-06 218497003820 Pfam match to entry PF01225 Mur_ligase, Mur ligase, catalytic domain , score 64.0, E-value 2.1e-16 218497003821 chaperonin GroL; Region: GroEL; TIGR02348 218497003822 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 218497003823 Pfam match to entry PF00118 cpn60_TCP1, TCP-1/cpn60 chaperonin family , score 162.2, E-value 5.9e-46 218497003824 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 218497003825 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 218497003826 active site 218497003827 metal binding site [ion binding]; metal-binding site 218497003828 Pfam match to entry PF00149 Metallophos, Calcineurin-like phosphoesterase , score 63.6, E-value 2.8e-16 218497003829 elongation factor P; Validated; Region: PRK00529 218497003830 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 218497003831 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 218497003832 RNA binding site [nucleotide binding]; other site 218497003833 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 218497003834 RNA binding site [nucleotide binding]; other site 218497003835 Pfam match to entry PF01132 EFP, Elongation factor P (EF-P) , score 258.9, E-value 4.4e-75 218497003836 AMP nucleosidase; Provisional; Region: PRK07115 218497003837 Pfam match to entry PF01048 PNP_UDP_1, Phosphorylase , score -27.4, E-value 2.2e-05 218497003838 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 218497003839 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 218497003840 TPP-binding site [chemical binding]; other site 218497003841 dimer interface [polypeptide binding]; other site 218497003842 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 218497003843 PYR/PP interface [polypeptide binding]; other site 218497003844 dimer interface [polypeptide binding]; other site 218497003845 TPP binding site [chemical binding]; other site 218497003846 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 218497003847 Pfam match to entry PF02780 transketolase_C, Transketolase, C-terminal domain , score 13.5, E-value 5.7e-05 218497003848 Pfam match to entry PF02779 transket_pyr, Transketolase, pyridine binding domain , score 214.0, E-value 1.5e-61 218497003849 PS00213 Lipocalin signature. 218497003850 Pfam match to entry PF00456 transketolase, Transketolase, thiamine diphosphate binding domain , score 507.2, E-value 8e-150 218497003851 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 218497003852 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 218497003853 motif 1; other site 218497003854 active site 218497003855 motif 2; other site 218497003856 motif 3; other site 218497003857 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 218497003858 DHHA1 domain; Region: DHHA1; pfam02272 218497003859 Pfam match to entry PF01411 tRNA-synt_2c, tRNA synthetases class II (A) , score 1326.8, E-value 0 218497003860 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218497003861 Pfam match to entry PF02272 DHHA1, DHHA1 domain , score 43.0, E-value 4.3e-10 218497003862 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 218497003863 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 218497003864 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218497003865 ATP binding site [chemical binding]; other site 218497003866 putative Mg++ binding site [ion binding]; other site 218497003867 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218497003868 nucleotide binding region [chemical binding]; other site 218497003869 ATP-binding site [chemical binding]; other site 218497003870 TRCF domain; Region: TRCF; pfam03461 218497003871 Pfam match to entry PF00270 DEAD, DEAD/DEAH box helicase , score 123.1, E-value 3.3e-34 218497003872 PS00017 ATP/GTP-binding site motif A (P-loop). 218497003873 Pfam match to entry PF00271 helicase_C, Helicase conserved C-terminal domain , score 74.0, E-value 2e-19 218497003874 Pfam match to entry PF03461 TRCF, TRCF domain , score 138.0, E-value 1.1e-38 218497003875 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 218497003876 substrate binding site [chemical binding]; other site 218497003877 active site 218497003878 Pfam match to entry PF01208 URO-D, Uroporphyrinogen decarboxylase (URO-D) , score 161.4, E-value 9.9e-46 218497003879 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 218497003880 HemN C-terminal domain; Region: HemN_C; pfam06969 218497003881 Pfam match to entry PF02473 Coprogen_an_ox, Oxygen-independent Coproporphyrinogen III oxidase , score 487.8, E-value 5.6e-144 218497003882 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 218497003883 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 218497003884 Pfam match to entry PF01593 Amino_oxidase, Flavin containing amine oxidoreductase , score 24.9, E-value 7.2e-08 218497003885 Predicted helix-turn-helix motif with score 988.000, SD 2.55 at aa 386-407, sequence VSILDHASRLGVTLPRVYEYLG 218497003886 Histone H1-like protein Hc1; Region: Hc1; pfam07432 218497003887 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 218497003888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218497003889 S-adenosylmethionine binding site [chemical binding]; other site 218497003890 PS01231 RNA methyltransferase trmA family signature 2. 218497003891 preprotein translocase, YajC subunit; Region: yajC; TIGR00739 218497003892 Pfam match to entry PF02699 DUF219, Uncharacterized secreted proteins, YajC family COG1862 , score 141.6, E-value 9e-40 218497003893 1 probable transmembrane helix predicted for CAB850 by TMHMM2.0 at aa 25-44 218497003894 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 218497003895 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 218497003896 catalytic loop [active] 218497003897 iron binding site [ion binding]; other site 218497003898 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 218497003899 FAD binding pocket [chemical binding]; other site 218497003900 FAD binding motif [chemical binding]; other site 218497003901 phosphate binding motif [ion binding]; other site 218497003902 beta-alpha-beta structure motif; other site 218497003903 NAD binding pocket [chemical binding]; other site 218497003904 1 probable transmembrane helix predicted for CAB851 by TMHMM2.0 at aa 7-29 218497003905 Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domain , score 51.9, E-value 9.5e-13 218497003906 Pfam match to entry PF00175 NAD_binding_1, Oxidoreductase NAD-binding domain , score 22.9, E-value 7.8e-07 218497003907 Protein of unknown function (DUF687); Region: DUF687; pfam05095 218497003908 3 probable transmembrane helices predicted for CAB852 by TMHMM2.0 at aa 259-281, 398-420 and 456-478 218497003909 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 218497003910 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 218497003911 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 218497003912 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 218497003913 Signal peptide predicted for CAB855 by SignalP 2.0 HMM (Signal peptide probabilty 0.750) with cleavage site probability 0.592 between residues 27 and 28 218497003914 5 probable transmembrane helices predicted for CAB855 by TMHMM2.0 at aa 21-43, 63-85, 98-120, 133-155 and 168-190 218497003915 Pfam match to entry PF01580 FtsK_SpoIIIE, FtsK/SpoIIIE family , score 216.3, E-value 2.9e-62 218497003916 PS00017 ATP/GTP-binding site motif A (P-loop). 218497003917 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 218497003918 Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily , score 28.6, E-value 1.5e-08 218497003919 Proteins containing SET domain [General function prediction only]; Region: COG2940 218497003920 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 218497003921 Pfam match to entry PF00856 SET, SET domain , score 147.2, E-value 1.8e-41 218497003922 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 218497003923 substrate binding site [chemical binding]; other site 218497003924 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 218497003925 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 218497003926 Pfam match to entry PF01235 Na_Ala_symp, Sodium:alanine symporter family , score 99.9, E-value 3.2e-27 218497003927 11 probable transmembrane helices predicted for CAB859 by TMHMM2.0 at aa 10-32, 67-89, 94-116, 146-168, 183-200, 207-229, 233-255, 300-322, 342-364, 385-407 and 412-429 218497003928 Signal peptide predicted for CAB860 by SignalP 2.0 HMM (Signal peptide probabilty 0.973) with cleavage site probability 0.607 between residues 28 and 29 218497003929 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218497003930 Signal peptide predicted for CAB861 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.496 between residues 24 and 25 218497003931 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 218497003932 homopentamer interface [polypeptide binding]; other site 218497003933 active site 218497003934 Pfam match to entry PF00885 DMRL_synthase, 6,7-dimethyl-8-ribityllumazine synthase , score 138.9, E-value 5.7e-39 218497003935 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 218497003936 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 218497003937 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 218497003938 dimerization interface [polypeptide binding]; other site 218497003939 active site 218497003940 Pfam match to entry PF00925 GTP_cyclohydro2, GTP cyclohydrolase II , score 349.4, E-value 2.6e-102 218497003941 Pfam match to entry PF00926 DHBP_synthase, 3,4-dihydroxy-2-butanone 4-phosphate synthase , score 340.9, E-value 9.5e-100 218497003942 PS00430 TonB-dependent receptor proteins signature 1. 218497003943 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 218497003944 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 218497003945 catalytic motif [active] 218497003946 Zn binding site [ion binding]; other site 218497003947 RibD C-terminal domain; Region: RibD_C; pfam01872 218497003948 Pfam match to entry PF01872 RibD_C, RibD C-terminal domain , score 222.9, E-value 3e-64 218497003949 Pfam match to entry PF00383 dCMP_cyt_deam, Cytidine and deoxycytidylate deaminase zinc-binding region , score 133.1, E-value 3.2e-37 218497003950 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 218497003951 seryl-tRNA synthetase; Provisional; Region: PRK05431 218497003952 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 218497003953 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 218497003954 dimer interface [polypeptide binding]; other site 218497003955 active site 218497003956 motif 1; other site 218497003957 motif 2; other site 218497003958 motif 3; other site 218497003959 Pfam match to entry PF02403 Seryl_tRNA_N, Seryl-tRNA synthetase N-terminal domain , score 52.4, E-value 6.3e-13 218497003960 Pfam match to entry PF00587 tRNA-synt_2b, tRNA synthetase class II core domain (G, H, P, S and T) , score 196.5, E-value 2.6e-56 218497003961 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 218497003962 CCC1-related protein family; Region: CCC1_like_1; cd02437 218497003963 4 probable transmembrane helices predicted for CAB866 by TMHMM2.0 at aa 37-59, 69-88, 185-207 and 222-244 218497003964 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 218497003965 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 218497003966 Soluble P-type ATPase [General function prediction only]; Region: COG4087 218497003967 7 probable transmembrane helices predicted for CAB867 by TMHMM2.0 at aa 41-63, 68-86, 106-128, 267-289, 304-326, 608-627 and 631-653 218497003968 Pfam match to entry PF00122 E1-E2_ATPase, E1-E2 ATPase , score 184.3, E-value 1.3e-52 218497003969 Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase , score 102.5, E-value 5.2e-28 218497003970 PS00154 E1-E2 ATPases phosphorylation site. 218497003971 PS01229 Hypothetical cof family signature 2. 218497003972 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 218497003973 Pfam match to entry PF01098 FTSW_RODA_SPOVE, Cell cycle protein , score 176.4, E-value 3.1e-50 218497003974 10 probable transmembrane helices predicted for CAB868 by TMHMM2.0 at aa 7-29, 51-70, 77-99, 109-131, 144-161, 166-185, 192-214, 287-309, 314-336 and 346-368 218497003975 PS00012 Phosphopantetheine attachment site. 218497003976 PS00428 Cell cycle proteins ftsW / rodA / spoVE signature. 218497003977 biotin--protein ligase; Provisional; Region: PRK05935 218497003978 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 218497003979 Pfam match to entry PF03099 BPL_LipA_LipB, Biotin/lipoate A/B protein ligase , score 57.4, E-value 2.1e-14 218497003980 1 probable transmembrane helix predicted for CAB870 by TMHMM2.0 at aa 5-27 218497003981 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 218497003982 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 218497003983 RNA binding surface [nucleotide binding]; other site 218497003984 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 218497003985 active site 218497003986 Pfam match to entry PF00849 PseudoU_synth_2, RNA pseudouridylate synthase , score 96.3, E-value 4e-26 218497003987 PS01149 Rsu family of pseudouridine synthase signature. 218497003988 Pfam match to entry PF01479 S4, S4 domain , score 39.6, E-value 4.7e-09 218497003989 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 218497003990 catalytic core [active] 218497003991 Pfam match to entry PF00300 PGAM, Phosphoglycerate mutase , score 199.8, E-value 2.8e-57 218497003992 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 218497003993 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 218497003994 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 218497003995 catalytic residue [active] 218497003996 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 218497003997 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 218497003998 NifU-like domain; Region: NifU; cl00484 218497003999 Pfam match to entry PF01592 NifU_N, NifU-like N terminal domain , score -11.9, E-value 5.9e-05 218497004000 Pfam match to entry PF01106 NifU-like, NifU-like domain , score 9.6, E-value 3.4e-05 218497004001 type III secretion system protein; Validated; Region: PRK05934 218497004002 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 218497004003 MgtE intracellular N domain; Region: MgtE_N; cl15244 218497004004 Signal peptide predicted for CAB875 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.684 between residues 28 and 29 218497004005 probable transmembrane helices predicted for CAB875 by TMHMM2.0 at aa 250-272 218497004006 flagellar assembly protein H; Validated; Region: fliH; PRK06669 218497004007 type III secretion system ATPase; Validated; Region: PRK05922 218497004008 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 218497004009 Walker A motif; other site 218497004010 ATP binding site [chemical binding]; other site 218497004011 Walker B motif; other site 218497004012 Pfam match to entry PF02874 ATP-synt_ab_N, ATP synthase alpha/beta family, beta-barrel domain , score 23.6, E-value 0.00031 218497004013 Pfam match to entry PF00006 ATP-synt_ab, ATP synthase alpha/beta family, nucleotide-binding domain , score 359.2, E-value 2.8e-105 218497004014 PS00152 ATP synthase alpha and beta subunits signature. 218497004015 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 218497004016 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 218497004017 substrate binding site; other site 218497004018 dimerization interface; other site 218497004019 Pfam match to entry PF01704 UDPGP, UTP--glucose-1-phosphate uridylyltransferase , score 336.4, E-value 2.1e-98 218497004020 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 218497004021 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 218497004022 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 218497004023 Pfam match to entry PF01210 NAD_Gly3P_dh, NAD-dependent glycerol-3-phosphate dehydrogenase , score 527.0, E-value 8.7e-156 218497004024 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 218497004025 Signal peptide predicted for CAB881 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.459 between residues 30 and 31 218497004026 Effector from type III secretion system; Region: Effector_1; pfam04518 218497004027 Effector from type III secretion system; Region: Effector_1; pfam04518 218497004028 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 218497004029 active site 218497004030 substrate-binding site [chemical binding]; other site 218497004031 metal-binding site [ion binding] 218497004032 GTP binding site [chemical binding]; other site 218497004033 Pfam match to entry PF00821 PEPCK, Phosphoenolpyruvate carboxykinase , score 1254.5, E-value 0 218497004034 PS00505 Phosphoenolpyruvate carboxykinase (GTP) signature. 218497004035 rod shape-determining protein MreB; Provisional; Region: PRK13927 218497004036 MreB and similar proteins; Region: MreB_like; cd10225 218497004037 nucleotide binding site [chemical binding]; other site 218497004038 Mg binding site [ion binding]; other site 218497004039 putative protofilament interaction site [polypeptide binding]; other site 218497004040 RodZ interaction site [polypeptide binding]; other site 218497004041 PS00017 ATP/GTP-binding site motif A (P-loop). 218497004042 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 218497004043 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 218497004044 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218497004045 ATP binding site [chemical binding]; other site 218497004046 putative Mg++ binding site [ion binding]; other site 218497004047 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218497004048 nucleotide binding region [chemical binding]; other site 218497004049 ATP-binding site [chemical binding]; other site 218497004050 Pfam match to entry PF00271 helicase_C, Helicase conserved C-terminal domain , score 94.4, E-value 1.5e-25 218497004051 Pfam match to entry PF00176 SNF2_N, SNF2 family N-terminal domain , score 299.6, E-value 2.4e-87 218497004052 trigger factor; Provisional; Region: tig; PRK01490 218497004053 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 218497004054 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 218497004055 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 218497004056 oligomer interface [polypeptide binding]; other site 218497004057 active site residues [active] 218497004058 Pfam match to entry PF00574 CLP_protease, Clp protease , score 341.0, E-value 8.4e-100 218497004059 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 218497004060 PS00381 Endopeptidase Clp serine active site. 218497004061 PS00382 Endopeptidase Clp histidine active site. 218497004062 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 218497004063 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 218497004064 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218497004065 Walker A motif; other site 218497004066 ATP binding site [chemical binding]; other site 218497004067 Walker B motif; other site 218497004068 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 218497004069 Pfam match to entry PF00004 AAA, ATPase associated with various cellular activities (AAA) , score 93.0, E-value 3.9e-25 218497004070 PS00017 ATP/GTP-binding site motif A (P-loop). 218497004071 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 218497004072 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 218497004073 active site 218497004074 NTP binding site [chemical binding]; other site 218497004075 metal binding triad [ion binding]; metal-binding site 218497004076 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 218497004077 Pfam match to entry PF01743 PolyA_pol, Poly A polymerase , score 236.2, E-value 3.1e-68 218497004078 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 218497004079 GTP-binding protein Der; Reviewed; Region: PRK00093 218497004080 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 218497004081 G1 box; other site 218497004082 GTP/Mg2+ binding site [chemical binding]; other site 218497004083 Switch I region; other site 218497004084 G2 box; other site 218497004085 Switch II region; other site 218497004086 G3 box; other site 218497004087 G4 box; other site 218497004088 G5 box; other site 218497004089 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 218497004090 G1 box; other site 218497004091 GTP/Mg2+ binding site [chemical binding]; other site 218497004092 Switch I region; other site 218497004093 G2 box; other site 218497004094 G3 box; other site 218497004095 Switch II region; other site 218497004096 G4 box; other site 218497004097 G5 box; other site 218497004098 PS00017 ATP/GTP-binding site motif A (P-loop). 218497004099 Pfam match to entry PF01926 MMR_HSR1, GTPase of unknown function , score 262.8, E-value 3.1e-76 218497004100 PS00017 ATP/GTP-binding site motif A (P-loop). 218497004101 Pseudogene. Similar to Chlamydophila caviae hypothetical protein CCA00924 SWALL:Q821L6 (EMBL:AE016997) (176 aa) fasta scores: E(): 1.3e-66, 90.9% id in 176 aa, N-terminal region similar to Chlamydia pneumoniae CT702 hypothetical protein CPN0843 or CPJ0843 or CP1026 SWALL:Q9Z763 (EMBL:AE001665) (66 aa) fasta scores: E(): 8.1e-10, 60.93% id in 64 aa, and C-terminal region to Chlamydia pneumoniae CT702 hypothetical protein CPN0842 or CPJ0842 SWALL:Q9Z764 (EMBL:AE001665) (58 aa) fasta scores: E(): 1.8e-07, 48.27% id in 58 aa. Note this CDS contains a framshift mutation following codon 112.;conserved hypothetical protein (pseudogene) 218497004102 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12899 218497004103 DEAD/DEAH box helicase; Region: DEAD; pfam00270 218497004104 ATP binding site [chemical binding]; other site 218497004105 putative Mg++ binding site [ion binding]; other site 218497004106 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 218497004107 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218497004108 nucleotide binding region [chemical binding]; other site 218497004109 ATP-binding site [chemical binding]; other site 218497004110 Pfam match to entry PF00271 helicase_C, Helicase conserved C-terminal domain , score 4.4, E-value 0.0067 218497004111 PS01312 Protein secA signatures. 218497004112 Pfam match to entry PF01043 SecA_protein, SecA protein, amino terminal region , score 606.9, E-value 7.7e-180 218497004113 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 218497004114 binding surface 218497004115 TPR motif; other site 218497004116 1 probable transmembrane helix predicted for CAB895 by TMHMM2.0 at aa 36-58 218497004117 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 218497004118 Pfam match to entry PF02666 PS_Dcarbxylase, Phosphatidylserine decarboxylase , score 314.8, E-value 6.7e-92 218497004119 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 218497004120 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 218497004121 trmE is a tRNA modification GTPase; Region: trmE; cd04164 218497004122 G1 box; other site 218497004123 GTP/Mg2+ binding site [chemical binding]; other site 218497004124 Switch I region; other site 218497004125 G2 box; other site 218497004126 Switch II region; other site 218497004127 G3 box; other site 218497004128 G4 box; other site 218497004129 G5 box; other site 218497004130 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 218497004131 Pfam match to entry PF01926 MMR_HSR1, GTPase of unknown function , score -15.5, E-value 1.1e-06 218497004132 PS00017 ATP/GTP-binding site motif A (P-loop). 218497004133 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 218497004134 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 218497004135 minor groove reading motif; other site 218497004136 helix-hairpin-helix signature motif; other site 218497004137 substrate binding pocket [chemical binding]; other site 218497004138 active site 218497004139 Pfam match to entry PF00730 HhH-GPD, HhH-GPD superfamily base excision DNA repair protein , score 208.2, E-value 8.3e-60 218497004140 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 218497004141 10 probable transmembrane helices predicted for CAB899 by TMHMM2.0 at aa 20-42, 47-69, 90-112, 127-149, 156-178, 198-220, 249-271, 300-322, 334-356 and 366-388 218497004142 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 218497004143 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218497004144 ATP binding site [chemical binding]; other site 218497004145 putative Mg++ binding site [ion binding]; other site 218497004146 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218497004147 nucleotide binding region [chemical binding]; other site 218497004148 ATP-binding site [chemical binding]; other site 218497004149 Pfam match to entry PF00176 SNF2_N, SNF2 family N-terminal domain , score 218.4, E-value 6.8e-63 218497004150 Pfam match to entry PF00271 helicase_C, Helicase conserved C-terminal domain , score 62.2, E-value 7e-16 218497004151 2 probable transmembrane helices predicted for CAB901 by TMHMM2.0 at aa 90-112 and 125-142 218497004152 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 218497004153 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 218497004154 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 218497004155 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 218497004156 Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase , score 313.8, E-value 1.3e-91 218497004157 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 218497004158 Pfam match to entry PF02852 pyr_redox_dim, Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain , score 163.9, E-value 1.8e-46 218497004159 lipoyl synthase; Provisional; Region: PRK05481 218497004160 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218497004161 FeS/SAM binding site; other site 218497004162 Pfam match to entry PF02546 Lipoate_synth, Lipoate synthase , score 593.5, E-value 8.4e-176 218497004163 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 218497004164 Signal peptide predicted for CAB904 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.730 between residues 24 and 25 218497004165 Pfam match to entry PF01514 YscJ_FliF, Secretory protein of YscJ/FliF family , score 99.1, E-value 5.7e-27 218497004166 1 probable transmembrane helix predicted for CAB904 by TMHMM2.0 at aa 238-260 218497004167 type III secretion system protein; Validated; Region: PRK06328 218497004168 Flagellar assembly protein FliH; Region: FliH; pfam02108 218497004169 FliP family; Region: FliP; cl00593 218497004170 type III secretion system protein; Reviewed; Region: PRK09617 218497004171 Signal peptide predicted for CAB907 by SignalP 2.0 HMM (Signal peptide probabilty 0.987) with cleavage site probability 0.962 between residues 21 and 22 218497004172 4 probable transmembrane helices predicted for CAB907 by TMHMM2.0 at aa 92-114, 134-156, 246-268 and 278-300 218497004173 Pfam match to entry PF00813 FliP, FliP family , score 259.8, E-value 2.4e-75 218497004174 PS01061 Flagella transport protein fliP family signature 2. 218497004175 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 218497004176 Signal peptide predicted for CAB908 by SignalP 2.0 HMM (Signal peptide probabilty 0.657) with cleavage site probability 0.446 between residues 46 and 47 218497004177 Pfam match to entry PF01313 Bac_export_3, Bacterial export proteins, family 3 , score 101.6, E-value 9.9e-28 218497004178 2 probable transmembrane helices predicted for CAB908 by TMHMM2.0 at aa 21-43 and 53-75 218497004179 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 218497004180 Pfam match to entry PF01311 Bac_export_1, Bacterial export proteins, family 1 , score 50.2, E-value 2.9e-12 218497004181 5 probable transmembrane helices predicted for CAB909 by TMHMM2.0 at aa 26-48, 53-75, 88-110, 207-229 and 241-263 218497004182 2 probable transmembrane helices predicted for CAB910 by TMHMM2.0 at aa 59-81 and 112-134 218497004183 Signal peptide predicted for CAB911 by SignalP 2.0 HMM (Signal peptide probabilty 0.983) with cleavage site probability 0.636 between residues 22 and 23 218497004184 Protein of unknown function (DUF1494); Region: DUF1494; pfam07379 218497004185 1 probable transmembrane helix predicted for CAB912 by TMHMM2.0 at aa 4-21 218497004186 Signal peptide predicted for CAB913 by SignalP 2.0 HMM (Signal peptide probabilty 0.722) with cleavage site probability 0.394 between residues 42 and 43 218497004187 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 218497004188 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 218497004189 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 218497004190 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 218497004191 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 218497004192 Pfam match to entry PF00482 GSPII_F, Bacterial type II secretion system protein F domain , score 187.4, E-value 1.5e-53 218497004193 3 probable transmembrane helices predicted for CAB915 by TMHMM2.0 at aa 166-188, 217-234 and 370-392 218497004194 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 218497004195 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 218497004196 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 218497004197 Walker A motif; other site 218497004198 ATP binding site [chemical binding]; other site 218497004199 Walker B motif; other site 218497004200 Pfam match to entry PF00437 GSPII_E, Type II/IV secretion system protein , score 543.9, E-value 6.9e-161 218497004201 PS00662 Bacterial type II secretion system protein E signature. 218497004202 PS00017 ATP/GTP-binding site motif A (P-loop). 218497004203 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 218497004204 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 218497004205 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 218497004206 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 218497004207 Pfam match to entry PF00263 GSPII_III, Bacterial type II and III secretion system protein , score 240.6, E-value 1.4e-69 218497004208 Signal peptide predicted for CAB917 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.826 between residues 25 and 26 218497004209 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 218497004210 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 218497004211 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 218497004212 active site 218497004213 Pfam match to entry PF00557 Peptidase_M24, metallopeptidase M24 , score 216.4, E-value 2.8e-62 218497004214 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 218497004215 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218497004216 ATP binding site [chemical binding]; other site 218497004217 Mg2+ binding site [ion binding]; other site 218497004218 G-X-G motif; other site 218497004219 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 218497004220 ATP binding site [chemical binding]; other site 218497004221 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 218497004222 Pfam match to entry PF01119 DNA_mis_repair, DNA mismatch repair protein, C-terminal domain , score 164.9, E-value 8.7e-47 218497004223 Pfam match to entry PF02518 HATPase_c, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase , score 26.1, E-value 5.3e-05 218497004224 PS00058 DNA mismatch repair proteins mutL / hexB / PMS1 signature. 218497004225 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 218497004226 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 218497004227 binding surface 218497004228 TPR motif; other site 218497004229 pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362 218497004230 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 218497004231 EamA-like transporter family; Region: EamA; pfam00892 218497004232 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 218497004233 Pfam match to entry PF00892 DUF6, Integral membrane protein DUF6 , score 71.0, E-value 1.7e-18 218497004234 9 probable transmembrane helices predicted for CAB925 by TMHMM2.0 at aa 28-50, 62-84, 94-111, 120-137, 147-169, 182-204, 214-236, 243-265 and 270-289 218497004235 Pfam match to entry PF00892 DUF6, Integral membrane protein DUF6 , score 97.5, E-value 1.7e-26 218497004236 Signal peptide predicted for CAB925 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.604 between residues 23 and 24 218497004237 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 218497004238 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cd01616 218497004239 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 218497004240 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 218497004241 active site 218497004242 dimer interface [polypeptide binding]; other site 218497004243 motif 1; other site 218497004244 motif 2; other site 218497004245 motif 3; other site 218497004246 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 218497004247 anticodon binding site; other site 218497004248 Pfam match to entry PF02824 TGS, TGS domain , score 33.0, E-value 4.4e-07 218497004249 Pfam match to entry PF00587 tRNA-synt_2b, tRNA synthetase class II core domain (G, H, P, S and T) , score 208.5, E-value 6.5e-60 218497004250 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 218497004251 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218497004252 Pfam match to entry PF03129 HGTP_anticodon, Anticodon binding domain , score 117.3, E-value 1.9e-32 218497004253 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 218497004254 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 218497004255 Pfam match to entry PF00991 ParA, ParA family ATPase , score 85.5, E-value 7.1e-23 218497004256 Uncharacterized protein family (UPF0137); Region: UPF0137; pfam03677 218497004257 Pfam match to entry PF03677 UPF0137, Uncharacterised protein family (UPF0137) , score 495.2, E-value 3.3e-146 218497004258 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 218497004259 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 218497004260 active site 218497004261 HIGH motif; other site 218497004262 dimer interface [polypeptide binding]; other site 218497004263 KMSKS motif; other site 218497004264 Pfam match to entry PF00579 tRNA-synt_1b, tRNA synthetases class I (W and Y) , score 355.0, E-value 5.4e-104 218497004265 This hit extended beyond the end of the feature by 1 aa and was clipped.; Predicted helix-turn-helix motif with score 1163.000, SD 3.15 at aa 324-345, sequence ETMEEVHDTLGLSHKWRSRLLP 218497004266 excinuclease ABC subunit B; Provisional; Region: PRK05298 218497004267 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218497004268 ATP binding site [chemical binding]; other site 218497004269 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218497004270 nucleotide binding region [chemical binding]; other site 218497004271 ATP-binding site [chemical binding]; other site 218497004272 Ultra-violet resistance protein B; Region: UvrB; pfam12344 218497004273 UvrB/uvrC motif; Region: UVR; pfam02151 218497004274 PS00017 ATP/GTP-binding site motif A (P-loop). 218497004275 Pfam match to entry PF00271 helicase_C, Helicase conserved C-terminal domain , score 68.7, E-value 7.8e-18 218497004276 Pfam match to entry PF02151 UVR, UvrB/uvrC motif , score 33.9, E-value 2.5e-07 218497004277 enolase; Provisional; Region: eno; PRK00077 218497004278 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 218497004279 dimer interface [polypeptide binding]; other site 218497004280 metal binding site [ion binding]; metal-binding site 218497004281 substrate binding pocket [chemical binding]; other site 218497004282 Pfam match to entry PF03952 enolase_N, Enolase, N-terminal domain , score 188.6, E-value 6.5e-54 218497004283 Pfam match to entry PF00113 enolase, Enolase, C-terminal TIM barrel domain , score 508.3, E-value 3.7e-150 218497004284 PS00164 Enolase signature. 218497004285 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 218497004286 HAMP domain; Region: HAMP; pfam00672 218497004287 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 218497004288 2 probable transmembrane helices predicted for CAB933 by TMHMM2.0 at aa 10-32 and 305-324 218497004289 Pfam match to entry PF00672 HAMP, HAMP domain , score 31.7, E-value 1.1e-06 218497004290 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 218497004291 Signal peptide predicted for CAB934 by SignalP 2.0 HMM (Signal peptide probabilty 0.999) with cleavage site probability 0.569 between residues 34 and 35 218497004292 2 probable transmembrane helices predicted for CAB934 by TMHMM2.0 at aa 273-291 and 298-315 218497004293 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 218497004294 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 218497004295 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218497004296 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 218497004297 L-aspartate oxidase; Provisional; Region: PRK06175 218497004298 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 218497004299 Pfam match to entry PF02910 succ_DH_flav_C, Fumarate reductase/succinate dehydrogenase flavoprotein C-terminal domain , score 177.6, E-value 1.3e-50 218497004300 Pfam match to entry PF00890 FAD_binding_2, FAD binding domain , score 302.3, E-value 3.9e-88 218497004301 PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site. 218497004302 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 218497004303 putative Iron-sulfur protein interface [polypeptide binding]; other site 218497004304 proximal heme binding site [chemical binding]; other site 218497004305 distal heme binding site [chemical binding]; other site 218497004306 putative dimer interface [polypeptide binding]; other site 218497004307 5 probable transmembrane helices predicted for CAB938 by TMHMM2.0 at aa 21-43, 74-96, 127-144, 232-254 and 275-297 218497004308 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 218497004309 active site 218497004310 Pfam match to entry PF01026 TatD_DNase, TatD related DNase , score 230.0, E-value 2.2e-66 218497004311 PS01091 Uncharacterized protein family UPF0006 signature 3. 218497004312 PS01090 Uncharacterized protein family UPF0006 signature 2. 218497004313 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 218497004314 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 218497004315 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 218497004316 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 218497004317 DsbD alpha interface [polypeptide binding]; other site 218497004318 catalytic residues [active] 218497004319 PS00194 Thioredoxin family active site. 218497004320 8 probable transmembrane helices predicted for CAB940 by TMHMM2.0 at aa 321-343, 356-378, 398-420, 450-472, 482-501, 521-538, 542-564 and 577-596 218497004321 Pfam match to entry PF02683 DsbD, Cytochrome C biogenesis protein transmembrane region , score -8.7, E-value 1.2e-05 218497004322 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 218497004323 3 probable transmembrane helices predicted for CAB941 by TMHMM2.0 at aa 20-39, 135-157 and 177-199 218497004324 Pfam match to entry PF01618 MotA_ExbB, MotA/TolQ/ExbB proton channel family , score 171.4, E-value 9.8e-49 218497004325 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 218497004326 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 218497004327 Pfam match to entry PF02472 ExbD, Biopolymer transport protein ExbD/TolR , score 31.7, E-value 4e-07 218497004328 1 probable transmembrane helix predicted for CAB942 by TMHMM2.0 at aa 13-35 218497004329 Signal peptide predicted for CAB943 by SignalP 2.0 HMM (Signal peptide probabilty 0.788) with cleavage site probability 0.706 between residues 16 and 17 218497004330 translocation protein TolB; Provisional; Region: tolB; PRK01029 218497004331 TolB amino-terminal domain; Region: TolB_N; pfam04052 218497004332 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 218497004333 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 218497004334 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 218497004335 Signal peptide predicted for CAB944 by SignalP 2.0 HMM (Signal peptide probabilty 0.913) with cleavage site probability 0.879 between residues 30 and 31 218497004336 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 218497004337 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 218497004338 ligand binding site [chemical binding]; other site 218497004339 Signal peptide predicted for CAB945 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.691 between residues 23 and 24 218497004340 Pfam match to entry PF00691 OmpA, OmpA family , score 107.2, E-value 2.1e-29 218497004341 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 218497004342 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 218497004343 Signal peptide predicted for CAB946 by SignalP 2.0 HMM (Signal peptide probabilty 0.995) with cleavage site probability 0.970 between residues 25 and 26 218497004344 Pfam match to entry PF01476 LysM, LysM domain , score 73.0, E-value 4e-19 218497004345 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 218497004346 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 218497004347 dimer interface [polypeptide binding]; other site 218497004348 decamer (pentamer of dimers) interface [polypeptide binding]; other site 218497004349 catalytic triad [active] 218497004350 peroxidatic and resolving cysteines [active] 218497004351 Pfam match to entry PF00578 AhpC-TSA, AhpC/TSA family , score 247.6, E-value 1.1e-71 218497004352 PS00017 ATP/GTP-binding site motif A (P-loop). 218497004353 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 218497004354 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 218497004355 ring oligomerisation interface [polypeptide binding]; other site 218497004356 ATP/Mg binding site [chemical binding]; other site 218497004357 stacking interactions; other site 218497004358 hinge regions; other site 218497004359 Pfam match to entry PF00118 cpn60_TCP1, TCP-1/cpn60 chaperonin family , score 436.8, E-value 1.3e-128 218497004360 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 218497004361 PS00109 Tyrosine protein kinases specific active-site signature. 218497004362 Signal peptide predicted for CAB951 by SignalP 2.0 HMM (Signal peptide probabilty 0.985) with cleavage site probability 0.719 between residues 25 and 26 218497004363 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 218497004364 active site 218497004365 dimerization interface [polypeptide binding]; other site 218497004366 Pfam match to entry PF01725 Ham1p_like, Ham1 family , score 189.5, E-value 3.4e-54 218497004367 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 218497004368 ligand binding site [chemical binding]; other site 218497004369 active site 218497004370 UGI interface [polypeptide binding]; other site 218497004371 catalytic site [active] 218497004372 Pfam match to entry PF03167 UDG, Uracil DNA glycosylase superfamily , score 249.7, E-value 2.6e-72 218497004373 PS00130 Uracil-DNA glycosylase signature. 218497004374 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 218497004375 Part of AAA domain; Region: AAA_19; pfam13245 218497004376 Family description; Region: UvrD_C_2; pfam13538 218497004377 Pfam match to entry PF00580 UvrD-helicase, UvrD/REP helicase , score 714.2, E-value 3.8e-212 218497004378 PS00017 ATP/GTP-binding site motif A (P-loop). 218497004379 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 218497004380 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 218497004381 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 218497004382 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 218497004383 Pfam match to entry PF00309 Sigma54_factors, Sigma-54 factors family , score 376.0, E-value 2.4e-110 218497004384 Predicted helix-turn-helix motif with score 1005.000, SD 2.61 at aa 177-334, sequence CDFLRIAKKCHCSPSNLRYALKNALTTIPWCPAQGYASSSNIQPALPDVYVAKQDRV WEIQISSQGLPPIKLNREVFHIYEQLPREEKKSLTQQILSAKWLIKNLRKREQTLFS IVEKILPHQENFLLGKTSCPKPLSVKILSEELPYHESTIFRAIE 218497004385 PS00718 Sigma-54 factors family signature 2. 218497004386 1 probable transmembrane helix predicted for CAB957 by TMHMM2.0 at aa 178-200 218497004387 DNA topoisomerase I/SWI domain fusion protein; Validated; Region: PRK06319 218497004388 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 218497004389 active site 218497004390 interdomain interaction site; other site 218497004391 putative metal-binding site [ion binding]; other site 218497004392 nucleotide binding site [chemical binding]; other site 218497004393 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 218497004394 domain I; other site 218497004395 DNA binding groove [nucleotide binding] 218497004396 phosphate binding site [ion binding]; other site 218497004397 domain II; other site 218497004398 domain III; other site 218497004399 nucleotide binding site [chemical binding]; other site 218497004400 catalytic site [active] 218497004401 domain IV; other site 218497004402 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 218497004403 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 218497004404 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 218497004405 SWIB/MDM2 domain; Region: SWIB; pfam02201 218497004406 Pfam match to entry PF01751 Toprim, Toprim domain , score 125.1, E-value 8.6e-35 218497004407 Pfam match to entry PF01131 Topoisom_bac, DNA topoisomerase , score 497.8, E-value 5.3e-147 218497004408 PS00396 Prokaryotic DNA topoisomerase I active site. 218497004409 Pfam match to entry PF01396 zf-C4_Topoisom, Topoisomerase DNA binding C4 zinc finger , score 24.1, E-value 8.6e-05 218497004410 Pfam match to entry PF01396 zf-C4_Topoisom, Topoisomerase DNA binding C4 zinc finger , score 53.9, E-value 2.3e-13 218497004411 Pfam match to entry PF01396 zf-C4_Topoisom, Topoisomerase DNA binding C4 zinc finger , score 27.5, E-value 2.1e-05 218497004412 Pfam match to entry PF02201 SWIB, BAF60b domain of the SWIB complex , score 113.0, E-value 3.8e-31 218497004413 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 218497004414 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 218497004415 FMN binding site [chemical binding]; other site 218497004416 active site 218497004417 catalytic residues [active] 218497004418 substrate binding site [chemical binding]; other site 218497004419 Pfam match to entry PF01207 UPF0034, Dihydrouridine synthase (Dus) , score 222.9, E-value 3e-64 218497004420 PS01136 Uncharacterized protein family UPF0034 signature. 218497004421 YGGT family; Region: YGGT; pfam02325 218497004422 Pfam match to entry PF02325 YGGT, YGGT family , score 104.1, E-value 1.8e-28 218497004423 2 probable transmembrane helices predicted for CAB960 by TMHMM2.0 at aa 5-27 and 56-78 218497004424 Signal peptide predicted for CAB962 by SignalP 2.0 HMM (Signal peptide probabilty 0.998) with cleavage site probability 0.649 between residues 29 and 30 218497004425 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218497004426 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 218497004427 Signal peptide predicted for CAB963 by SignalP 2.0 HMM (Signal peptide probabilty 1.000) with cleavage site probability 0.923 between residues 22 and 23 218497004428 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 218497004429 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 218497004430 Pfam match to entry PF01812 5-FTHF_cyc-lig, 5-formyltetrahydrofolate cyclo-ligase , score 113.5, E-value 2.6e-31 218497004431 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 218497004432 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 218497004433 hexamer interface [polypeptide binding]; other site 218497004434 Walker A motif; other site 218497004435 ATP binding site [chemical binding]; other site 218497004436 Walker B motif; other site 218497004437 Pfam match to entry PF00154 recA, recA bacterial DNA recombination protein , score 703.9, E-value 4.8e-209 218497004438 PS00017 ATP/GTP-binding site motif A (P-loop). 218497004439 PS00321 recA signature. 218497004440 putative folate metabolism protein, CADD family; Region: fol_rel_CADD; TIGR04305 218497004441 putative folate metabolism gamma-glutamate ligase; Region: intra_fol_E_lig; TIGR04132 218497004442 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 218497004443 Pfam match to entry PF01996 DUF129, Protein of unknown function DUF129 , score 235.8, E-value 4.1e-68 218497004444 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 218497004445 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 218497004446 folate binding site [chemical binding]; other site 218497004447 NADP+ binding site [chemical binding]; other site 218497004448 Pfam match to entry PF00186 DiHfolate_red, Dihydrofolate reductase , score 97.2, E-value 2.1e-26 218497004449 PS00075 Dihydrofolate reductase signature. 218497004450 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 218497004451 catalytic center binding site [active] 218497004452 ATP binding site [chemical binding]; other site 218497004453 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 218497004454 dihydropteroate synthase; Region: DHPS; TIGR01496 218497004455 substrate binding pocket [chemical binding]; other site 218497004456 dimer interface [polypeptide binding]; other site 218497004457 inhibitor binding site; inhibition site 218497004458 Pfam match to entry PF00809 Pterin_bind, Pterin binding enzyme , score 270.4, E-value 1.5e-78 218497004459 Pfam match to entry PF01288 HPPK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) , score 201.4, E-value 8.9e-58 218497004460 Similar to Bacillus subtilis dihydroneopterin aldolase FolB or FolA SWALL:FOLB_BACSU (SWALL:P28823) (120 aa) fasta scores: E(): 0.2, 25.64% id in 78 aa, and to Chlamydia pneumoniae probable dihydroneopterin aldolase FolB SWALL:FOLB_CHLPN (SWALL:Q9Z7E9) (134 aa) fasta scores: E(): 2.5e-30, 62.4% id in 125 aa. Note lacks any obvious and appropriate translational start site.;dihydroneopterin aldolase (pseudogene) 218497004461 Pfam match to entry PF02152 FolB, Dihydroneopterin aldolase , score 119.0, E-value 6e-33 218497004462 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 218497004463 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 218497004464 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 218497004465 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 218497004466 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 218497004467 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 218497004468 DNA binding residues [nucleotide binding] 218497004469 PS00716 Sigma-70 factors family signature 2. 218497004470 Predicted helix-turn-helix motif with score 1686.000, SD 4.93 at aa 519-540, sequence KTLEEVGSAFNVTRERIRQIEA 218497004471 Predicted helix-turn-helix motif with score 1296.000, SD 3.60 at aa 426-447, sequence PTPEELAEELGLTPDRVREIYK 218497004472 PS00715 Sigma-70 factors family signature 1. 218497004473 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 218497004474 Pfam match to entry PF00140 sigma70_r1_2, Sigma-70 factor, region 1.2 , score 71.7, E-value 1e-18 218497004475 Pfam match to entry PF03979 sigma70_r1_1, Sigma-70 factor, region 1.1 , score 94.5, E-value 1.4e-25 218497004476 Uncharacterized protein family (UPF0242); Region: UPF0242; pfam06785 218497004477 probable transmembrane helices predicted for CAB972 by TMHMM2.0 at aa 41-58 218497004478 Signal peptide predicted for CAB972 by SignalP 2.0 HMM (Signal peptide probabilty 0.852) with cleavage site probability 0.422 between residues 37 and 38 218497004479 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 218497004480 Pfam match to entry PF01649 Ribosomal_S20p, Ribosomal protein S20 , score 77.7, E-value 1.6e-20 218497004481 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218497004482 1 probable transmembrane helix predicted for CAB974 by TMHMM2.0 at aa 249-271 218497004483 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 218497004484 AAA domain; Region: AAA_30; pfam13604 218497004485 Family description; Region: UvrD_C_2; pfam13538 218497004486 PS00017 ATP/GTP-binding site motif A (P-loop). 218497004487 Protein of unknown function (DUF1347); Region: DUF1347; pfam07079 218497004488 Signal peptide predicted for CAB976 by SignalP 2.0 HMM (Signal peptide probabilty 0.997) with cleavage site probability 0.397 between residues 40 and 41 218497004489 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 218497004490 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218497004491 DNA binding site [nucleotide binding] 218497004492 Pfam match to entry PF00486 trans_reg_C, Transcriptional regulatory protein, C terminal , score 34.6, E-value 1.4e-07 218497004493 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 218497004494 putative trimer interface [polypeptide binding]; other site 218497004495 putative CoA binding site [chemical binding]; other site 218497004496 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats) , score 11.3, E-value 1.5 218497004497 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats) , score 6.4, E-value 7.2 218497004498 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats) , score 3.9, E-value 15 218497004499 Pfam match to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats) , score 14.2, E-value 0.21 218497004500 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 218497004501 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 218497004502 substrate binding pocket [chemical binding]; other site 218497004503 aspartate-rich region 1; other site 218497004504 Pfam match to entry PF00348 polyprenyl_synt, Polyprenyl synthetase , score 114.5, E-value 1.3e-31 218497004505 PS00723 Polyprenyl synthetases signature 1. 218497004506 PS00444 Polyprenyl synthetases signature 2. 218497004507 Predicted alternative thymidylate synthase [Nucleotide transport and metabolism]; Region: THY1; COG1351 218497004508 Thymidylate synthase complementing protein; Region: Thy1; cl03630 218497004509 Pfam match to entry PF02511 Thy1, Thymidylate synthase complementing protein , score -60.9, E-value 0.0024