-- dump date 20140619_040725 -- class Genbank::misc_feature -- table misc_feature_note -- id note 331636000001 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 331636000002 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 331636000003 Uncharacterized protein family (UPF0137); Region: UPF0137; pfam03677 331636000004 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 331636000005 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 331636000006 active site 331636000007 catalytic residues [active] 331636000008 DNA binding site [nucleotide binding] 331636000009 Int/Topo IB signature motif; other site 331636000010 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 331636000011 active site 331636000012 catalytic residues [active] 331636000013 DNA binding site [nucleotide binding] 331636000014 Int/Topo IB signature motif; other site 331636000015 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 331636000016 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 331636000017 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 331636000018 Walker A motif; other site 331636000019 ATP binding site [chemical binding]; other site 331636000020 Walker B motif; other site 331636000021 DNA binding loops [nucleotide binding] 331636000022 Chlamydia virulence protein PGP3-D; Region: Chlam_vir; pfam05475 331636000023 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 331636000024 dimer interface [polypeptide binding]; other site 331636000025 active site 331636000026 aspartate-rich active site metal binding site; other site 331636000027 allosteric magnesium binding site [ion binding]; other site 331636000028 Schiff base residues; other site 331636000029 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrA [Energy production and conversion]; Region: NqrA; COG1726 331636000030 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 331636000031 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 331636000032 transcript cleavage factor/unknown domain fusion protein; Validated; Region: PRK06330 331636000033 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 331636000034 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 331636000035 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 331636000036 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331636000037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331636000038 homodimer interface [polypeptide binding]; other site 331636000039 catalytic residue [active] 331636000040 rod shape-determining protein MreC; Provisional; Region: PRK14872 331636000041 rod shape-determining protein MreC; Region: MreC; pfam04085 331636000042 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 331636000043 Part of AAA domain; Region: AAA_19; pfam13245 331636000044 Family description; Region: UvrD_C_2; pfam13538 331636000045 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 331636000046 H+ Antiporter protein; Region: 2A0121; TIGR00900 331636000047 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331636000048 putative substrate translocation pore; other site 331636000049 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 331636000050 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 331636000051 active site residue [active] 331636000052 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 331636000053 ribosomal protein S4, bacterial/organelle type; Region: rpsD_bact; TIGR01017 331636000054 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 331636000055 RNA binding surface [nucleotide binding]; other site 331636000056 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 331636000057 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 331636000058 AP (apurinic/apyrimidinic) site pocket; other site 331636000059 DNA interaction; other site 331636000060 Metal-binding active site; metal-binding site 331636000061 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 331636000062 MviN-like protein; Region: MVIN; pfam03023 331636000063 Effector from type III secretion system; Region: Effector_1; pfam04518 331636000064 Effector from type III secretion system; Region: Effector_1; pfam04518 331636000065 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 331636000066 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 331636000067 Walker A/P-loop; other site 331636000068 ATP binding site [chemical binding]; other site 331636000069 Q-loop/lid; other site 331636000070 ABC transporter signature motif; other site 331636000071 Walker B; other site 331636000072 D-loop; other site 331636000073 H-loop/switch region; other site 331636000074 Protein of unknown function (DUF1137); Region: DUF1137; pfam06587 331636000075 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 331636000076 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 331636000077 hypothetical protein; Provisional; Region: PRK01064 331636000078 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 331636000079 G-X-X-G motif; other site 331636000080 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 331636000081 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 331636000082 RNA binding surface [nucleotide binding]; other site 331636000083 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 331636000084 active site 331636000085 DNA topoisomerase IV subunit A; Provisional; Region: PRK09630 331636000086 CAP-like domain; other site 331636000087 DNA gyrase/topoisomerase IV, subunit A; Region: DNA_topoisoIV; pfam00521 331636000088 active site 331636000089 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 331636000090 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 331636000091 ATP binding site [chemical binding]; other site 331636000092 Mg2+ binding site [ion binding]; other site 331636000093 G-X-G motif; other site 331636000094 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 331636000095 ATP binding site [chemical binding]; other site 331636000096 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 331636000097 active site 331636000098 putative metal-binding site [ion binding]; other site 331636000099 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 331636000100 glutamyl-tRNA reductase; Validated; Region: hemA; PRK00676 331636000101 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 331636000102 NAD(P) binding pocket [chemical binding]; other site 331636000103 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 331636000104 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 331636000105 phosphopeptide binding site; other site 331636000106 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 331636000107 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 331636000108 phosphopeptide binding site; other site 331636000109 type III secretion system ATPase; Provisional; Region: PRK06315 331636000110 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 331636000111 Walker A motif/ATP binding site; other site 331636000112 Walker B motif; other site 331636000113 type III secretion system protein; Validated; Region: PRK05933 331636000114 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 331636000115 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 331636000116 Catalytic domain of Protein Kinases; Region: PKc; cd00180 331636000117 active site 331636000118 ATP binding site [chemical binding]; other site 331636000119 substrate binding site [chemical binding]; other site 331636000120 activation loop (A-loop); other site 331636000121 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 331636000122 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 331636000123 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 331636000124 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 331636000125 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 331636000126 ATP:guanido phosphotransferase, C-terminal catalytic domain; Region: ATP-gua_Ptrans; pfam00217 331636000127 ADP binding site [chemical binding]; other site 331636000128 phosphagen binding site; other site 331636000129 substrate specificity loop; other site 331636000130 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 331636000131 UvrB/uvrC motif; Region: UVR; pfam02151 331636000132 ribosome recycling factor; Reviewed; Region: frr; PRK00083 331636000133 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 331636000134 hinge region; other site 331636000135 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 331636000136 putative nucleotide binding site [chemical binding]; other site 331636000137 uridine monophosphate binding site [chemical binding]; other site 331636000138 homohexameric interface [polypeptide binding]; other site 331636000139 elongation factor Ts; Provisional; Region: tsf; PRK09377 331636000140 UBA/TS-N domain; Region: UBA; pfam00627 331636000141 Elongation factor TS; Region: EF_TS; pfam00889 331636000142 Elongation factor TS; Region: EF_TS; pfam00889 331636000143 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 331636000144 rRNA interaction site [nucleotide binding]; other site 331636000145 S8 interaction site; other site 331636000146 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 331636000147 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 331636000148 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 331636000149 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 331636000150 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 331636000151 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331636000152 binding surface 331636000153 TPR motif; other site 331636000154 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331636000155 binding surface 331636000156 TPR motif; other site 331636000157 Tetratricopeptide repeat; Region: TPR_16; pfam13432 331636000158 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 331636000159 putative ABC transporter; Region: ycf24; CHL00085 331636000160 FeS assembly ATPase SufC; Region: sufC; TIGR01978 331636000161 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 331636000162 Walker A/P-loop; other site 331636000163 ATP binding site [chemical binding]; other site 331636000164 Q-loop/lid; other site 331636000165 ABC transporter signature motif; other site 331636000166 Walker B; other site 331636000167 D-loop; other site 331636000168 H-loop/switch region; other site 331636000169 FeS assembly protein SufD; Region: sufD; TIGR01981 331636000170 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 331636000171 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 331636000172 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 331636000173 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 331636000174 catalytic residue [active] 331636000175 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 331636000176 putative active site [active] 331636000177 putative metal binding site [ion binding]; other site 331636000178 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 331636000179 ParB-like nuclease domain; Region: ParBc; pfam02195 331636000180 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 331636000181 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 331636000182 Walker A/P-loop; other site 331636000183 ATP binding site [chemical binding]; other site 331636000184 Q-loop/lid; other site 331636000185 ABC transporter signature motif; other site 331636000186 Walker B; other site 331636000187 D-loop; other site 331636000188 H-loop/switch region; other site 331636000189 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 331636000190 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 331636000191 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 331636000192 Walker A/P-loop; other site 331636000193 ATP binding site [chemical binding]; other site 331636000194 Q-loop/lid; other site 331636000195 ABC transporter signature motif; other site 331636000196 Walker B; other site 331636000197 D-loop; other site 331636000198 H-loop/switch region; other site 331636000199 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 331636000200 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 331636000201 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 331636000202 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 331636000203 Phosphoglycerate kinase; Region: PGK; pfam00162 331636000204 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 331636000205 substrate binding site [chemical binding]; other site 331636000206 hinge regions; other site 331636000207 ADP binding site [chemical binding]; other site 331636000208 catalytic site [active] 331636000209 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 331636000210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331636000211 S-adenosylmethionine binding site [chemical binding]; other site 331636000212 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 331636000213 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 331636000214 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 331636000215 ATP binding site [chemical binding]; other site 331636000216 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 331636000217 Mg2+ binding site [ion binding]; other site 331636000218 G-X-G motif; other site 331636000219 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 331636000220 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 331636000221 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 331636000222 active site 331636000223 PHP Thumb interface [polypeptide binding]; other site 331636000224 metal binding site [ion binding]; metal-binding site 331636000225 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 331636000226 generic binding surface I; other site 331636000227 generic binding surface II; other site 331636000228 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 331636000229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331636000230 putative substrate translocation pore; other site 331636000231 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 331636000232 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 331636000233 dimer interface [polypeptide binding]; other site 331636000234 motif 1; other site 331636000235 active site 331636000236 motif 2; other site 331636000237 motif 3; other site 331636000238 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 331636000239 anticodon binding site; other site 331636000240 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 331636000241 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 331636000242 dimer interface [polypeptide binding]; other site 331636000243 anticodon binding site; other site 331636000244 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 331636000245 homodimer interface [polypeptide binding]; other site 331636000246 motif 1; other site 331636000247 active site 331636000248 motif 2; other site 331636000249 GAD domain; Region: GAD; pfam02938 331636000250 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 331636000251 active site 331636000252 motif 3; other site 331636000253 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 331636000254 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 331636000255 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 331636000256 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 331636000257 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 331636000258 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 331636000259 catalytic residues [active] 331636000260 cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657 331636000261 Protein of unknown function (DUF2709); Region: DUF2709; pfam10915 331636000262 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 331636000263 DNA polymerase III subunit epsilon; Validated; Region: PRK06310 331636000264 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 331636000265 active site 331636000266 catalytic site [active] 331636000267 substrate binding site [chemical binding]; other site 331636000268 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 331636000269 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 331636000270 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 331636000271 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 331636000272 putative active site [active] 331636000273 catalytic triad [active] 331636000274 putative dimer interface [polypeptide binding]; other site 331636000275 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 331636000276 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 331636000277 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 331636000278 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 331636000279 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 331636000280 active site 331636000281 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 331636000282 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 331636000283 putative active site [active] 331636000284 substrate binding site [chemical binding]; other site 331636000285 putative cosubstrate binding site; other site 331636000286 catalytic site [active] 331636000287 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 331636000288 substrate binding site [chemical binding]; other site 331636000289 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 331636000290 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 331636000291 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 331636000292 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 331636000293 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 331636000294 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 331636000295 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 331636000296 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 331636000297 putative translocon binding site; other site 331636000298 protein-rRNA interface [nucleotide binding]; other site 331636000299 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 331636000300 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 331636000301 G-X-X-G motif; other site 331636000302 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 331636000303 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 331636000304 23S rRNA interface [nucleotide binding]; other site 331636000305 5S rRNA interface [nucleotide binding]; other site 331636000306 putative antibiotic binding site [chemical binding]; other site 331636000307 L25 interface [polypeptide binding]; other site 331636000308 L27 interface [polypeptide binding]; other site 331636000309 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 331636000310 23S rRNA interface [nucleotide binding]; other site 331636000311 putative translocon interaction site; other site 331636000312 signal recognition particle (SRP54) interaction site; other site 331636000313 L23 interface [polypeptide binding]; other site 331636000314 trigger factor interaction site; other site 331636000315 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 331636000316 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 331636000317 Ribosomal protein L24 [Translation, ribosomal structure and biogenesis]; Region: RplX; COG0198 331636000318 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 331636000319 RNA binding site [nucleotide binding]; other site 331636000320 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 331636000321 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 331636000322 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 331636000323 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 331636000324 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 331636000325 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 331636000326 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 331636000327 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 331636000328 5S rRNA interface [nucleotide binding]; other site 331636000329 L27 interface [polypeptide binding]; other site 331636000330 23S rRNA interface [nucleotide binding]; other site 331636000331 L5 interface [polypeptide binding]; other site 331636000332 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 331636000333 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 331636000334 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 331636000335 ribosomal protein L15, bacterial/organelle; Region: rplO_bact; TIGR01071 331636000336 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 331636000337 SecY translocase; Region: SecY; pfam00344 331636000338 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 331636000339 30S ribosomal protein S13; Region: bact_S13; TIGR03631 331636000340 30S ribosomal protein S11; Validated; Region: PRK05309 331636000341 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 331636000342 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 331636000343 alphaNTD - beta interaction site [polypeptide binding]; other site 331636000344 alphaNTD homodimer interface [polypeptide binding]; other site 331636000345 alphaNTD - beta' interaction site [polypeptide binding]; other site 331636000346 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 331636000347 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 331636000348 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 331636000349 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 331636000350 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 331636000351 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 331636000352 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 331636000353 active site 331636000354 putative DNA-binding cleft [nucleotide binding]; other site 331636000355 dimer interface [polypeptide binding]; other site 331636000356 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 331636000357 RuvA N terminal domain; Region: RuvA_N; pfam01330 331636000358 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 331636000359 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 331636000360 active site 331636000361 multimer interface [polypeptide binding]; other site 331636000362 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 331636000363 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 331636000364 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 331636000365 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 331636000366 replicative DNA helicase; Provisional; Region: PRK06321 331636000367 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 331636000368 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 331636000369 Walker A motif; other site 331636000370 ATP binding site [chemical binding]; other site 331636000371 Walker B motif; other site 331636000372 DNA binding loops [nucleotide binding] 331636000373 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 331636000374 TLC ATP/ADP transporter; Region: TLC; pfam03219 331636000375 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 331636000376 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 331636000377 tandem repeat interface [polypeptide binding]; other site 331636000378 oligomer interface [polypeptide binding]; other site 331636000379 active site residues [active] 331636000380 DNA polymerase I; Provisional; Region: PRK05755 331636000381 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 331636000382 active site 331636000383 metal binding site 1 [ion binding]; metal-binding site 331636000384 putative 5' ssDNA interaction site; other site 331636000385 metal binding site 3; metal-binding site 331636000386 metal binding site 2 [ion binding]; metal-binding site 331636000387 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 331636000388 putative DNA binding site [nucleotide binding]; other site 331636000389 putative metal binding site [ion binding]; other site 331636000390 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 331636000391 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 331636000392 active site 331636000393 DNA binding site [nucleotide binding] 331636000394 catalytic site [active] 331636000395 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 331636000396 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 331636000397 CoA-binding site [chemical binding]; other site 331636000398 ATP-binding [chemical binding]; other site 331636000399 transcription termination factor Rho; Provisional; Region: rho; PRK09376 331636000400 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 331636000401 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 331636000402 RNA binding site [nucleotide binding]; other site 331636000403 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 331636000404 multimer interface [polypeptide binding]; other site 331636000405 Walker A motif; other site 331636000406 ATP binding site [chemical binding]; other site 331636000407 Walker B motif; other site 331636000408 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 331636000409 active site 331636000410 glucose-1-phosphate adenylyltransferase; Region: glgC; TIGR02091 331636000411 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 331636000412 ligand binding site; other site 331636000413 oligomer interface; other site 331636000414 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 331636000415 dimer interface [polypeptide binding]; other site 331636000416 N-terminal domain interface [polypeptide binding]; other site 331636000417 sulfate 1 binding site; other site 331636000418 Deinococcus radiodurans DR1119 and related proteins, metallophosphatase domain; Region: MPP_DR1119; cd07393 331636000419 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 331636000420 putative active site [active] 331636000421 putative metal binding site [ion binding]; other site 331636000422 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 331636000423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331636000424 S-adenosylmethionine binding site [chemical binding]; other site 331636000425 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 331636000426 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331636000427 substrate binding pocket [chemical binding]; other site 331636000428 membrane-bound complex binding site; other site 331636000429 hinge residues; other site 331636000430 ferrochelatase; Reviewed; Region: hemH; PRK00035 331636000431 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 331636000432 C-terminal domain interface [polypeptide binding]; other site 331636000433 active site 331636000434 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 331636000435 active site 331636000436 N-terminal domain interface [polypeptide binding]; other site 331636000437 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331636000438 TPR motif; other site 331636000439 binding surface 331636000440 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 331636000441 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 331636000442 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 331636000443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 331636000444 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 331636000445 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 331636000446 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 331636000447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331636000448 dimer interface [polypeptide binding]; other site 331636000449 conserved gate region; other site 331636000450 putative PBP binding loops; other site 331636000451 ABC-ATPase subunit interface; other site 331636000452 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 331636000453 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 331636000454 DNA binding site [nucleotide binding] 331636000455 active site 331636000456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 331636000457 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 331636000458 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 331636000459 putative tRNA-binding site [nucleotide binding]; other site 331636000460 B3/4 domain; Region: B3_4; pfam03483 331636000461 tRNA synthetase B5 domain; Region: B5; smart00874 331636000462 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 331636000463 dimer interface [polypeptide binding]; other site 331636000464 motif 1; other site 331636000465 motif 3; other site 331636000466 motif 2; other site 331636000467 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 331636000468 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 331636000469 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 331636000470 Uncharacterized conserved protein [Function unknown]; Region: COG1723 331636000471 Recombination protein O N terminal; Region: RecO_N; pfam11967 331636000472 DNA repair protein RecO; Region: reco; TIGR00613 331636000473 Recombination protein O C terminal; Region: RecO_C; pfam02565 331636000474 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 331636000475 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 331636000476 30S subunit binding site; other site 331636000477 Response regulator receiver domain; Region: Response_reg; pfam00072 331636000478 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331636000479 active site 331636000480 phosphorylation site [posttranslational modification] 331636000481 intermolecular recognition site; other site 331636000482 dimerization interface [polypeptide binding]; other site 331636000483 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331636000484 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 331636000485 Walker A motif; other site 331636000486 ATP binding site [chemical binding]; other site 331636000487 Walker B motif; other site 331636000488 arginine finger; other site 331636000489 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 331636000490 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 331636000491 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 331636000492 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 331636000493 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331636000494 dimer interface [polypeptide binding]; other site 331636000495 phosphorylation site [posttranslational modification] 331636000496 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331636000497 ATP binding site [chemical binding]; other site 331636000498 Mg2+ binding site [ion binding]; other site 331636000499 G-X-G motif; other site 331636000500 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 331636000501 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 331636000502 dimerization interface 3.5A [polypeptide binding]; other site 331636000503 active site 331636000504 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 331636000505 substrate binding site; other site 331636000506 dimer interface; other site 331636000507 phosphodiesterase YaeI; Provisional; Region: PRK11340 331636000508 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 331636000509 putative active site [active] 331636000510 putative metal binding site [ion binding]; other site 331636000511 SWIB/MDM2 domain; Region: SWIB; pfam02201 331636000512 This domain is found in peptide chain release factors; Region: PCRF; smart00937 331636000513 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 331636000514 RF-1 domain; Region: RF-1; pfam00472 331636000515 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 331636000516 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331636000517 Coenzyme A binding pocket [chemical binding]; other site 331636000518 SprT-like family; Region: SprT-like; pfam10263 331636000519 DNA-binding regulatory protein, YebC/PmpR family; Region: TIGR01033 331636000520 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 331636000521 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 331636000522 Domain of Unknown Function (DUF1547); Region: DUF1547; pfam07577 331636000523 I/LWEQ domain; Region: ILWEQ; smart00307 331636000524 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 331636000525 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 331636000526 hinge; other site 331636000527 active site 331636000528 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 331636000529 arginine-tRNA ligase; Region: PLN02286 331636000530 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 331636000531 active site 331636000532 HIGH motif; other site 331636000533 KMSK motif region; other site 331636000534 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 331636000535 tRNA binding surface [nucleotide binding]; other site 331636000536 anticodon binding site; other site 331636000537 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 331636000538 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 331636000539 putative acyl-acceptor binding pocket; other site 331636000540 cytidylate kinase; Provisional; Region: cmk; PRK00023 331636000541 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 331636000542 CMP-binding site; other site 331636000543 The sites determining sugar specificity; other site 331636000544 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 331636000545 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 331636000546 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14840 331636000547 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 331636000548 catalytic residue [active] 331636000549 putative FPP diphosphate binding site; other site 331636000550 putative FPP binding hydrophobic cleft; other site 331636000551 dimer interface [polypeptide binding]; other site 331636000552 putative IPP diphosphate binding site; other site 331636000553 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK12911 331636000554 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 331636000555 Protein export membrane protein; Region: SecD_SecF; pfam02355 331636000556 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 331636000557 DHH family; Region: DHH; pfam01368 331636000558 DHHA1 domain; Region: DHHA1; pfam02272 331636000559 Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677 331636000560 Helix-turn-helix domain; Region: HTH_17; pfam12728 331636000561 Helix-turn-helix domain; Region: HTH_17; pfam12728 331636000562 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 331636000563 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 331636000564 HIGH motif; other site 331636000565 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 331636000566 active site 331636000567 KMSKS motif; other site 331636000568 Chlamydia cysteine-rich outer membrane protein 3; Region: Chlam_OMP3; pfam03503 331636000569 Chlamydia cysteine-rich outer membrane protein 6; Region: Chlam_OMP6; pfam03504 331636000570 Domain of unknown function DUF11; Region: DUF11; pfam01345 331636000571 Domain of unknown function DUF11; Region: DUF11; pfam01345 331636000572 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA); Region: CRPA; pfam05745 331636000573 Opioid growth factor receptor (OGFr) conserved region; Region: OGFr_N; pfam04664 331636000574 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 331636000575 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 331636000576 protein binding site [polypeptide binding]; other site 331636000577 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 331636000578 Catalytic dyad [active] 331636000579 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 331636000580 ATP binding site [chemical binding]; other site 331636000581 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 331636000582 S17 interaction site [polypeptide binding]; other site 331636000583 S8 interaction site; other site 331636000584 16S rRNA interaction site [nucleotide binding]; other site 331636000585 streptomycin interaction site [chemical binding]; other site 331636000586 23S rRNA interaction site [nucleotide binding]; other site 331636000587 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 331636000588 30S ribosomal protein S7; Validated; Region: PRK05302 331636000589 elongation factor G; Reviewed; Region: PRK12739 331636000590 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 331636000591 G1 box; other site 331636000592 putative GEF interaction site [polypeptide binding]; other site 331636000593 GTP/Mg2+ binding site [chemical binding]; other site 331636000594 Switch I region; other site 331636000595 G2 box; other site 331636000596 G3 box; other site 331636000597 Switch II region; other site 331636000598 G4 box; other site 331636000599 G5 box; other site 331636000600 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 331636000601 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 331636000602 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 331636000603 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 331636000604 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 331636000605 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 331636000606 FAD binding pocket [chemical binding]; other site 331636000607 conserved FAD binding motif [chemical binding]; other site 331636000608 phosphate binding motif [ion binding]; other site 331636000609 beta-alpha-beta structure motif; other site 331636000610 NAD binding pocket [chemical binding]; other site 331636000611 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 331636000612 homotrimer interaction site [polypeptide binding]; other site 331636000613 zinc binding site [ion binding]; other site 331636000614 CDP-binding sites; other site 331636000615 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 331636000616 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 331636000617 GTPase CgtA; Reviewed; Region: obgE; PRK12299 331636000618 GTP1/OBG; Region: GTP1_OBG; pfam01018 331636000619 Obg GTPase; Region: Obg; cd01898 331636000620 G1 box; other site 331636000621 GTP/Mg2+ binding site [chemical binding]; other site 331636000622 Switch I region; other site 331636000623 G2 box; other site 331636000624 G3 box; other site 331636000625 Switch II region; other site 331636000626 G4 box; other site 331636000627 G5 box; other site 331636000628 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 331636000629 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 331636000630 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 331636000631 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 331636000632 putative metal binding residues [ion binding]; other site 331636000633 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 331636000634 thiamine phosphate binding site [chemical binding]; other site 331636000635 active site 331636000636 pyrophosphate binding site [ion binding]; other site 331636000637 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 331636000638 substrate binding site [chemical binding]; other site 331636000639 multimerization interface [polypeptide binding]; other site 331636000640 ATP binding site [chemical binding]; other site 331636000641 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 331636000642 Autotransporter beta-domain; Region: Autotransporter; pfam03797 331636000643 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 331636000644 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 331636000645 Autotransporter beta-domain; Region: Autotransporter; pfam03797 331636000646 YtxH-like protein; Region: YtxH; pfam12732 331636000647 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 331636000648 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 331636000649 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 331636000650 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 331636000651 lipoprotein signal peptidase; Provisional; Region: PRK14787 331636000652 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 331636000653 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327 331636000654 ATP cone domain; Region: ATP-cone; pfam03477 331636000655 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 331636000656 Lumazine binding domain; Region: Lum_binding; pfam00677 331636000657 Lumazine binding domain; Region: Lum_binding; pfam00677 331636000658 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 331636000659 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331636000660 S-adenosylmethionine binding site [chemical binding]; other site 331636000661 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 331636000662 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 331636000663 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 331636000664 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 331636000665 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 331636000666 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 331636000667 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 331636000668 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 331636000669 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 331636000670 E3 interaction surface; other site 331636000671 lipoyl attachment site [posttranslational modification]; other site 331636000672 e3 binding domain; Region: E3_binding; pfam02817 331636000673 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 331636000674 KpsF/GutQ family protein; Region: kpsF; TIGR00393 331636000675 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 331636000676 putative active site [active] 331636000677 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 331636000678 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 331636000679 Putative zinc ribbon domain; Region: DUF164; pfam02591 331636000680 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 331636000681 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 331636000682 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 331636000683 active site 331636000684 serine hydroxymethyltransferase; Provisional; Region: PRK13580 331636000685 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 331636000686 dimer interface [polypeptide binding]; other site 331636000687 active site 331636000688 glycine-pyridoxal phosphate binding site [chemical binding]; other site 331636000689 folate binding site [chemical binding]; other site 331636000690 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 331636000691 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 331636000692 oligomer interface [polypeptide binding]; other site 331636000693 active site residues [active] 331636000694 diaminopimelate epimerase; Region: DapF; TIGR00652 331636000695 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 331636000696 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 331636000697 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 331636000698 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 331636000699 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331636000700 S-adenosylmethionine binding site [chemical binding]; other site 331636000701 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 331636000702 hypothetical protein; Provisional; Region: PRK05926 331636000703 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331636000704 FeS/SAM binding site; other site 331636000705 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 331636000706 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 331636000707 anti sigma factor interaction site; other site 331636000708 regulatory phosphorylation site [posttranslational modification]; other site 331636000709 FOG: CBS domain [General function prediction only]; Region: COG0517 331636000710 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 331636000711 Transporter associated domain; Region: CorC_HlyC; smart01091 331636000712 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 331636000713 Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137 331636000714 Uncharacterized conserved protein [Function unknown]; Region: COG2928 331636000715 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 331636000716 active site 331636000717 DNA binding site [nucleotide binding] 331636000718 Exoribonuclease R [Transcription]; Region: VacB; COG0557 331636000719 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 331636000720 RNA binding site [nucleotide binding]; other site 331636000721 RNB domain; Region: RNB; pfam00773 331636000722 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 331636000723 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 331636000724 nucleotide binding site [chemical binding]; other site 331636000725 NEF interaction site [polypeptide binding]; other site 331636000726 SBD interface [polypeptide binding]; other site 331636000727 GrpE; Region: GrpE; pfam01025 331636000728 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 331636000729 dimer interface [polypeptide binding]; other site 331636000730 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 331636000731 Transcriptional regulator of heat shock gene [Transcription]; Region: HrcA; COG1420 331636000732 prolyl-tRNA synthetase; Provisional; Region: PRK09194 331636000733 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 331636000734 dimer interface [polypeptide binding]; other site 331636000735 motif 1; other site 331636000736 active site 331636000737 motif 2; other site 331636000738 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 331636000739 putative deacylase active site [active] 331636000740 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 331636000741 active site 331636000742 motif 3; other site 331636000743 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 331636000744 anticodon binding site; other site 331636000745 hypothetical protein; Validated; Region: PRK00647 331636000746 ABC transporter substrate binding protein; Region: ABC_sub_bind; cl17301 331636000747 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 331636000748 LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542 331636000749 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331636000750 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331636000751 homodimer interface [polypeptide binding]; other site 331636000752 catalytic residue [active] 331636000753 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 331636000754 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 331636000755 Uncharacterized protein family (UPF0160); Region: UPF0160; cl01749 331636000756 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 331636000757 nucleotide binding site/active site [active] 331636000758 HEAT repeats; Region: HEAT_2; pfam13646 331636000759 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 331636000760 Na binding site [ion binding]; other site 331636000761 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 331636000762 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 331636000763 Peptidase C65 Otubain; Region: Peptidase_C65; pfam10275 331636000764 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331636000765 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 331636000766 substrate binding pocket [chemical binding]; other site 331636000767 membrane-bound complex binding site; other site 331636000768 hinge residues; other site 331636000769 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 331636000770 putative hydrolase; Provisional; Region: PRK02113 331636000771 GTPases [General function prediction only]; Region: HflX; COG2262 331636000772 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 331636000773 HflX GTPase family; Region: HflX; cd01878 331636000774 G1 box; other site 331636000775 GTP/Mg2+ binding site [chemical binding]; other site 331636000776 Switch I region; other site 331636000777 G2 box; other site 331636000778 G3 box; other site 331636000779 Switch II region; other site 331636000780 G4 box; other site 331636000781 G5 box; other site 331636000782 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 331636000783 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 331636000784 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331636000785 FeS/SAM binding site; other site 331636000786 glycogen branching enzyme; Provisional; Region: PRK05402 331636000787 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 331636000788 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 331636000789 active site 331636000790 catalytic site [active] 331636000791 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 331636000792 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 331636000793 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 331636000794 Autotransporter beta-domain; Region: Autotransporter; smart00869 331636000795 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 331636000796 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 331636000797 Autotransporter beta-domain; Region: Autotransporter; smart00869 331636000798 Autotransporter beta-domain; Region: Autotransporter; pfam03797 331636000799 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 331636000800 Autotransporter beta-domain; Region: Autotransporter; pfam03797 331636000801 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 331636000802 Autotransporter beta-domain; Region: Autotransporter; pfam03797 331636000803 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 331636000804 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 331636000805 Autotransporter beta-domain; Region: Autotransporter; pfam03797 331636000806 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 331636000807 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 331636000808 Autotransporter beta-domain; Region: Autotransporter; pfam03797 331636000809 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 331636000810 Autotransporter beta-domain; Region: Autotransporter; pfam03797 331636000811 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 331636000812 Autotransporter beta-domain; Region: Autotransporter; pfam03797 331636000813 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 331636000814 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 331636000815 Autotransporter beta-domain; Region: Autotransporter; pfam03797 331636000816 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 331636000817 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 331636000818 Autotransporter beta-domain; Region: Autotransporter; pfam03797 331636000819 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 331636000820 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 331636000821 Autotransporter beta-domain; Region: Autotransporter; pfam03797 331636000822 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 331636000823 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 331636000824 Autotransporter beta-domain; Region: Autotransporter; pfam03797 331636000825 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 331636000826 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 331636000827 Autotransporter beta-domain; Region: Autotransporter; pfam03797 331636000828 potential frameshift: common BLAST hit: gi|62184915|ref|YP_219700.1| polymorphic outer membrane protein 331636000829 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 331636000830 Autotransporter beta-domain; Region: Autotransporter; pfam03797 331636000831 Uncharacterized conserved protein [Function unknown]; Region: COG2155 331636000832 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 331636000833 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 331636000834 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 331636000835 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 331636000836 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 331636000837 GatB domain; Region: GatB_Yqey; pfam02637 331636000838 ribonuclease HIII; Provisional; Region: PRK00996 331636000839 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 331636000840 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 331636000841 RNA/DNA hybrid binding site [nucleotide binding]; other site 331636000842 active site 331636000843 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 331636000844 Helix-turn-helix domain; Region: HTH_25; pfam13413 331636000845 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 331636000846 potential frameshift: common BLAST hit: gi|89898510|ref|YP_515620.1| outer membrane protein 331636000847 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 331636000848 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 331636000849 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 331636000850 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 331636000851 catalytic residues [active] 331636000852 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 331636000853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331636000854 S-adenosylmethionine binding site [chemical binding]; other site 331636000855 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 331636000856 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 331636000857 TPP-binding site; other site 331636000858 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 331636000859 PYR/PP interface [polypeptide binding]; other site 331636000860 dimer interface [polypeptide binding]; other site 331636000861 TPP binding site [chemical binding]; other site 331636000862 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 331636000863 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 331636000864 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 331636000865 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 331636000866 generic binding surface II; other site 331636000867 generic binding surface I; other site 331636000868 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 331636000869 triosephosphate isomerase; Provisional; Region: PRK14565 331636000870 substrate binding site [chemical binding]; other site 331636000871 dimer interface [polypeptide binding]; other site 331636000872 catalytic triad [active] 331636000873 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 331636000874 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 331636000875 active site 331636000876 catalytic residues [active] 331636000877 metal binding site [ion binding]; metal-binding site 331636000878 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 331636000879 Maf-like protein; Region: Maf; pfam02545 331636000880 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 331636000881 active site 331636000882 dimer interface [polypeptide binding]; other site 331636000883 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 331636000884 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 331636000885 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 331636000886 ABC transporter; Region: ABC_tran_2; pfam12848 331636000887 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 331636000888 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 331636000889 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 331636000890 active site 331636000891 Int/Topo IB signature motif; other site 331636000892 ribonuclease Z; Region: RNase_Z; TIGR02651 331636000893 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 331636000894 Found in ATP-dependent protease La (LON); Region: LON; smart00464 331636000895 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331636000896 Walker A motif; other site 331636000897 ATP binding site [chemical binding]; other site 331636000898 Walker B motif; other site 331636000899 arginine finger; other site 331636000900 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 331636000901 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 331636000902 Glycoprotease family; Region: Peptidase_M22; pfam00814 331636000903 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 331636000904 chaperone protein DnaJ; Provisional; Region: PRK14284 331636000905 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 331636000906 HSP70 interaction site [polypeptide binding]; other site 331636000907 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 331636000908 Zn binding sites [ion binding]; other site 331636000909 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 331636000910 dimer interface [polypeptide binding]; other site 331636000911 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 331636000912 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 331636000913 tetramer interface [polypeptide binding]; other site 331636000914 TPP-binding site [chemical binding]; other site 331636000915 heterodimer interface [polypeptide binding]; other site 331636000916 phosphorylation loop region [posttranslational modification] 331636000917 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 331636000918 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 331636000919 alpha subunit interface [polypeptide binding]; other site 331636000920 TPP binding site [chemical binding]; other site 331636000921 heterodimer interface [polypeptide binding]; other site 331636000922 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 331636000923 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 331636000924 Competence protein; Region: Competence; pfam03772 331636000925 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 331636000926 dimerization domain swap beta strand [polypeptide binding]; other site 331636000927 regulatory protein interface [polypeptide binding]; other site 331636000928 active site 331636000929 regulatory phosphorylation site [posttranslational modification]; other site 331636000930 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 331636000931 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 331636000932 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 331636000933 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 331636000934 hypothetical protein; Validated; Region: PRK00153 331636000935 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06305 331636000936 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331636000937 Walker A motif; other site 331636000938 ATP binding site [chemical binding]; other site 331636000939 Walker B motif; other site 331636000940 arginine finger; other site 331636000941 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 331636000942 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 331636000943 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 331636000944 Zn2+ binding site [ion binding]; other site 331636000945 Mg2+ binding site [ion binding]; other site 331636000946 porphobilinogen deaminase; Provisional; Region: PRK01066 331636000947 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 331636000948 domain interfaces; other site 331636000949 active site 331636000950 DNA repair protein RadA; Provisional; Region: PRK11823 331636000951 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 331636000952 Walker A motif/ATP binding site; other site 331636000953 ATP binding site [chemical binding]; other site 331636000954 Walker B motif; other site 331636000955 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 331636000956 ribonuclease III; Reviewed; Region: rnc; PRK00102 331636000957 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 331636000958 dimerization interface [polypeptide binding]; other site 331636000959 active site 331636000960 metal binding site [ion binding]; metal-binding site 331636000961 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 331636000962 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 331636000963 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 331636000964 active site 331636000965 substrate binding site [chemical binding]; other site 331636000966 metal binding site [ion binding]; metal-binding site 331636000967 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 331636000968 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 331636000969 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 331636000970 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 331636000971 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 331636000972 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 331636000973 trimer interface [polypeptide binding]; other site 331636000974 active site 331636000975 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 331636000976 active site 331636000977 phosphorylation site [posttranslational modification] 331636000978 Helix-turn-helix domain; Region: HTH_17; pfam12728 331636000979 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 331636000980 active site 331636000981 phosphorylation site [posttranslational modification] 331636000982 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 331636000983 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 331636000984 Ligand Binding Site [chemical binding]; other site 331636000985 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 331636000986 Clp amino terminal domain; Region: Clp_N; pfam02861 331636000987 Clp amino terminal domain; Region: Clp_N; pfam02861 331636000988 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331636000989 Walker A motif; other site 331636000990 ATP binding site [chemical binding]; other site 331636000991 Walker B motif; other site 331636000992 arginine finger; other site 331636000993 UvrB/uvrC motif; Region: UVR; pfam02151 331636000994 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331636000995 Walker A motif; other site 331636000996 ATP binding site [chemical binding]; other site 331636000997 Walker B motif; other site 331636000998 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 331636000999 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 331636001000 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 331636001001 PLD-like domain; Region: PLDc_2; pfam13091 331636001002 putative active site [active] 331636001003 catalytic site [active] 331636001004 Chlamydial GcvH-like protein upstream region protein; Region: near_not_gcvH; TIGR03076 331636001005 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 331636001006 lipoyl attachment site [posttranslational modification]; other site 331636001007 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK01061 331636001008 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD [Energy production and conversion]; Region: NqrD; COG1347 331636001009 FMN-binding domain; Region: FMN_bind; cl01081 331636001010 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 331636001011 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK01024 331636001012 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 331636001013 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 331636001014 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 331636001015 DnaA N-terminal domain; Region: DnaA_N; pfam11638 331636001016 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331636001017 Walker A motif; other site 331636001018 ATP binding site [chemical binding]; other site 331636001019 Walker B motif; other site 331636001020 arginine finger; other site 331636001021 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 331636001022 DnaA box-binding interface [nucleotide binding]; other site 331636001023 TPR repeat; Region: TPR_11; pfam13414 331636001024 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331636001025 binding surface 331636001026 TPR motif; other site 331636001027 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 331636001028 MraW methylase family; Region: Methyltransf_5; cl17771 331636001029 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 331636001030 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 331636001031 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 331636001032 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 331636001033 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 331636001034 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 331636001035 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 331636001036 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 331636001037 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 331636001038 active site 331636001039 metal binding site [ion binding]; metal-binding site 331636001040 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 331636001041 IHF - DNA interface [nucleotide binding]; other site 331636001042 IHF dimer interface [polypeptide binding]; other site 331636001043 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 331636001044 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; pfam03255 331636001045 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 331636001046 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 331636001047 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331636001048 Walker A/P-loop; other site 331636001049 ATP binding site [chemical binding]; other site 331636001050 Q-loop/lid; other site 331636001051 ABC transporter signature motif; other site 331636001052 Walker B; other site 331636001053 D-loop; other site 331636001054 H-loop/switch region; other site 331636001055 nucleosidase; Provisional; Region: PRK05634 331636001056 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 331636001057 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 331636001058 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 331636001059 active site 331636001060 catalytic site [active] 331636001061 substrate binding site [chemical binding]; other site 331636001062 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 331636001063 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 331636001064 Flagellar biogenesis protein [Cell motility and secretion]; Region: FliO; COG3190 331636001065 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 331636001066 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06300 331636001067 enoyl-[acyl-carrier-protein] reductase; Region: PLN02730 331636001068 NAD(P) binding site [chemical binding]; other site 331636001069 active site 331636001070 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 331636001071 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 331636001072 RNA binding surface [nucleotide binding]; other site 331636001073 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 331636001074 active site 331636001075 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 331636001076 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 331636001077 minor groove reading motif; other site 331636001078 helix-hairpin-helix signature motif; other site 331636001079 substrate binding pocket [chemical binding]; other site 331636001080 active site 331636001081 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 331636001082 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 331636001083 DNA binding and oxoG recognition site [nucleotide binding] 331636001084 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 331636001085 homodimer interface [polypeptide binding]; other site 331636001086 metal binding site [ion binding]; metal-binding site 331636001087 CAAX protease self-immunity; Region: Abi; pfam02517 331636001088 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 331636001089 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 331636001090 active site 331636001091 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 331636001092 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 331636001093 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 331636001094 catalytic residue [active] 331636001095 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 331636001096 Domain of unknown function DUF21; Region: DUF21; pfam01595 331636001097 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 331636001098 Transporter associated domain; Region: CorC_HlyC; smart01091 331636001099 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 331636001100 Domain of unknown function DUF21; Region: DUF21; pfam01595 331636001101 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 331636001102 Transporter associated domain; Region: CorC_HlyC; smart01091 331636001103 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 331636001104 trimer interface [polypeptide binding]; other site 331636001105 active site 331636001106 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 331636001107 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331636001108 Walker A motif; other site 331636001109 ATP binding site [chemical binding]; other site 331636001110 Walker B motif; other site 331636001111 arginine finger; other site 331636001112 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 331636001113 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 331636001114 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 331636001115 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 331636001116 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 331636001117 active site 331636001118 catalytic site [active] 331636001119 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 331636001120 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 331636001121 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 331636001122 dimer interface [polypeptide binding]; other site 331636001123 ssDNA binding site [nucleotide binding]; other site 331636001124 tetramer (dimer of dimers) interface [polypeptide binding]; other site 331636001125 multifunctional aminopeptidase A; Provisional; Region: PRK00913 331636001126 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 331636001127 interface (dimer of trimers) [polypeptide binding]; other site 331636001128 Substrate-binding/catalytic site; other site 331636001129 Zn-binding sites [ion binding]; other site 331636001130 Histone H1-like nucleoprotein HC2; Region: HC2; pfam07382 331636001131 hypothetical protein; Provisional; Region: PRK05907 331636001132 Predicted methyltransferases [General function prediction only]; Region: COG0313 331636001133 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 331636001134 putative SAM binding site [chemical binding]; other site 331636001135 homodimer interface [polypeptide binding]; other site 331636001136 coproporphyrinogen III oxidase; Provisional; Region: PRK06294 331636001137 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331636001138 FeS/SAM binding site; other site 331636001139 HemN C-terminal domain; Region: HemN_C; pfam06969 331636001140 Protein of unknown function (DUF342); Region: DUF342; pfam03961 331636001141 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 331636001142 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 331636001143 TPP-binding site [chemical binding]; other site 331636001144 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 331636001145 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 331636001146 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 331636001147 E3 interaction surface; other site 331636001148 lipoyl attachment site [posttranslational modification]; other site 331636001149 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 331636001150 uncharacterized protein, YfiH family; Region: TIGR00726 331636001151 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 331636001152 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 331636001153 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional; Region: PRK02048 331636001154 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 331636001155 ADP-ribose binding site [chemical binding]; other site 331636001156 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cd02749 331636001157 ADP-ribose binding site [chemical binding]; other site 331636001158 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 331636001159 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 331636001160 catalytic loop [active] 331636001161 iron binding site [ion binding]; other site 331636001162 type III secretion system protein; Validated; Region: PRK05910 331636001163 FHIPEP family; Region: FHIPEP; pfam00771 331636001164 RNA polymerase sigma factor sigma-28; Reviewed; Region: PRK05911 331636001165 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 331636001166 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 331636001167 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 331636001168 DNA binding residues [nucleotide binding] 331636001169 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 331636001170 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 331636001171 active site 331636001172 HIGH motif; other site 331636001173 dimer interface [polypeptide binding]; other site 331636001174 KMSKS motif; other site 331636001175 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 331636001176 RNA binding surface [nucleotide binding]; other site 331636001177 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873 331636001178 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 331636001179 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 331636001180 GTP-binding protein LepA; Provisional; Region: PRK05433 331636001181 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 331636001182 G1 box; other site 331636001183 putative GEF interaction site [polypeptide binding]; other site 331636001184 GTP/Mg2+ binding site [chemical binding]; other site 331636001185 Switch I region; other site 331636001186 G2 box; other site 331636001187 G3 box; other site 331636001188 Switch II region; other site 331636001189 G4 box; other site 331636001190 G5 box; other site 331636001191 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 331636001192 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 331636001193 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 331636001194 Protein of unknown function (DUF1389); Region: DUF1389; pfam07146 331636001195 ADP/ATP carrier protein family; Region: AAA; TIGR00769 331636001196 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 331636001197 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 331636001198 intersubunit interface [polypeptide binding]; other site 331636001199 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 331636001200 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 331636001201 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 331636001202 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 331636001203 ABC-ATPase subunit interface; other site 331636001204 dimer interface [polypeptide binding]; other site 331636001205 putative PBP binding regions; other site 331636001206 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 331636001207 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 331636001208 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 331636001209 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 331636001210 ABC-ATPase subunit interface; other site 331636001211 dimer interface [polypeptide binding]; other site 331636001212 putative PBP binding regions; other site 331636001213 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 331636001214 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 331636001215 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 331636001216 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 331636001217 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 331636001218 RIP metalloprotease RseP; Region: TIGR00054 331636001219 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 331636001220 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 331636001221 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 331636001222 putative substrate binding region [chemical binding]; other site 331636001223 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 331636001224 Putative serine esterase (DUF676); Region: DUF676; pfam05057 331636001225 recombination protein F; Reviewed; Region: recF; PRK00064 331636001226 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331636001227 Walker A/P-loop; other site 331636001228 ATP binding site [chemical binding]; other site 331636001229 Q-loop/lid; other site 331636001230 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331636001231 ABC transporter signature motif; other site 331636001232 Walker B; other site 331636001233 D-loop; other site 331636001234 H-loop/switch region; other site 331636001235 DNA polymerase III subunit beta; Validated; Region: PRK05643 331636001236 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 331636001237 putative DNA binding surface [nucleotide binding]; other site 331636001238 dimer interface [polypeptide binding]; other site 331636001239 beta-clamp/clamp loader binding surface; other site 331636001240 beta-clamp/translesion DNA polymerase binding surface; other site 331636001241 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 331636001242 SmpB-tmRNA interface; other site 331636001243 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 331636001244 ApbE family; Region: ApbE; pfam02424 331636001245 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14181 331636001246 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 331636001247 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 331636001248 homodimer interface [polypeptide binding]; other site 331636001249 NADP binding site [chemical binding]; other site 331636001250 substrate binding site [chemical binding]; other site 331636001251 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 331636001252 PLD-like domain; Region: PLDc_2; pfam13091 331636001253 putative active site [active] 331636001254 catalytic site [active] 331636001255 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 331636001256 PLD-like domain; Region: PLDc_2; pfam13091 331636001257 putative active site [active] 331636001258 catalytic site [active] 331636001259 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 331636001260 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 331636001261 4-alpha-glucanotransferase; Region: Glyco_hydro_77; pfam02446 331636001262 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 331636001263 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 331636001264 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 331636001265 FHIPEP family; Region: FHIPEP; pfam00771 331636001266 type III secretion system protein; Validated; Region: PRK06298 331636001267 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 331636001268 GTP-binding protein YchF; Reviewed; Region: PRK09601 331636001269 YchF GTPase; Region: YchF; cd01900 331636001270 G1 box; other site 331636001271 GTP/Mg2+ binding site [chemical binding]; other site 331636001272 Switch I region; other site 331636001273 G2 box; other site 331636001274 Switch II region; other site 331636001275 G3 box; other site 331636001276 G4 box; other site 331636001277 G5 box; other site 331636001278 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 331636001279 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 331636001280 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 331636001281 active site 331636001282 Riboflavin kinase; Region: Flavokinase; pfam01687 331636001283 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00989 331636001284 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 331636001285 RNA binding site [nucleotide binding]; other site 331636001286 active site 331636001287 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 331636001288 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 331636001289 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 331636001290 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 331636001291 G1 box; other site 331636001292 putative GEF interaction site [polypeptide binding]; other site 331636001293 GTP/Mg2+ binding site [chemical binding]; other site 331636001294 Switch I region; other site 331636001295 G2 box; other site 331636001296 G3 box; other site 331636001297 Switch II region; other site 331636001298 G4 box; other site 331636001299 G5 box; other site 331636001300 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 331636001301 Translation-initiation factor 2; Region: IF-2; pfam11987 331636001302 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 331636001303 transcription termination factor NusA; Region: NusA; TIGR01953 331636001304 NusA N-terminal domain; Region: NusA_N; pfam08529 331636001305 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 331636001306 RNA binding site [nucleotide binding]; other site 331636001307 homodimer interface [polypeptide binding]; other site 331636001308 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 331636001309 G-X-X-G motif; other site 331636001310 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 331636001311 G-X-X-G motif; other site 331636001312 ribosomal protein S1; Region: rpsA; TIGR00717 331636001313 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 331636001314 RNA binding site [nucleotide binding]; other site 331636001315 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 331636001316 RNA binding site [nucleotide binding]; other site 331636001317 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 331636001318 RNA binding site [nucleotide binding]; other site 331636001319 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 331636001320 RNA binding site [nucleotide binding]; other site 331636001321 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 331636001322 RNA binding site [nucleotide binding]; other site 331636001323 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 331636001324 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 331636001325 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331636001326 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 331636001327 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 331636001328 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01001 331636001329 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 331636001330 chromosomal replication initiation protein; Provisional; Region: PRK12422 331636001331 DnaA N-terminal domain; Region: DnaA_N; pfam11638 331636001332 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331636001333 Walker A motif; other site 331636001334 ATP binding site [chemical binding]; other site 331636001335 Walker B motif; other site 331636001336 arginine finger; other site 331636001337 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 331636001338 DnaA box-binding interface [nucleotide binding]; other site 331636001339 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 331636001340 homodimer interface [polypeptide binding]; other site 331636001341 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 331636001342 active site pocket [active] 331636001343 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 331636001344 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 331636001345 E3 interaction surface; other site 331636001346 lipoyl attachment site [posttranslational modification]; other site 331636001347 e3 binding domain; Region: E3_binding; pfam02817 331636001348 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 331636001349 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 331636001350 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 331636001351 alpha subunit interface [polypeptide binding]; other site 331636001352 TPP binding site [chemical binding]; other site 331636001353 heterodimer interface [polypeptide binding]; other site 331636001354 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 331636001355 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 331636001356 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 331636001357 tetramer interface [polypeptide binding]; other site 331636001358 TPP-binding site [chemical binding]; other site 331636001359 heterodimer interface [polypeptide binding]; other site 331636001360 phosphorylation loop region [posttranslational modification] 331636001361 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 331636001362 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 331636001363 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 331636001364 trimer interface [polypeptide binding]; other site 331636001365 active site 331636001366 UDP-GlcNAc binding site [chemical binding]; other site 331636001367 lipid binding site [chemical binding]; lipid-binding site 331636001368 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 331636001369 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 331636001370 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 331636001371 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 331636001372 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 331636001373 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 331636001374 Surface antigen; Region: Bac_surface_Ag; pfam01103 331636001375 recombination protein RecR; Reviewed; Region: recR; PRK00076 331636001376 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 331636001377 putative active site [active] 331636001378 putative metal-binding site [ion binding]; other site 331636001379 tetramer interface [polypeptide binding]; other site 331636001380 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 331636001381 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 331636001382 dimer interface [polypeptide binding]; other site 331636001383 active site 331636001384 CoA binding pocket [chemical binding]; other site 331636001385 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 331636001386 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 331636001387 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 331636001388 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 331636001389 NAD(P) binding site [chemical binding]; other site 331636001390 homotetramer interface [polypeptide binding]; other site 331636001391 homodimer interface [polypeptide binding]; other site 331636001392 active site 331636001393 acyl carrier protein; Provisional; Region: acpP; PRK00982 331636001394 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 331636001395 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 331636001396 ligand binding site [chemical binding]; other site 331636001397 flexible hinge region; other site 331636001398 TLC ATP/ADP transporter; Region: TLC; cl03940 331636001399 Na+-dependent transporters of the SNF family [General function prediction only]; Region: COG0733 331636001400 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 331636001401 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 331636001402 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 331636001403 MgtE intracellular N domain; Region: MgtE_N; pfam03448 331636001404 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 331636001405 Divalent cation transporter; Region: MgtE; pfam01769 331636001406 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 331636001407 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 331636001408 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 331636001409 putative active site; other site 331636001410 catalytic residue [active] 331636001411 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 331636001412 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331636001413 Walker A/P-loop; other site 331636001414 ATP binding site [chemical binding]; other site 331636001415 Q-loop/lid; other site 331636001416 ABC transporter signature motif; other site 331636001417 Walker B; other site 331636001418 D-loop; other site 331636001419 H-loop/switch region; other site 331636001420 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 331636001421 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 331636001422 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 331636001423 Protein of unknown function (DUF721); Region: DUF721; pfam05258 331636001424 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 331636001425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331636001426 ATP binding site [chemical binding]; other site 331636001427 Mg2+ binding site [ion binding]; other site 331636001428 G-X-G motif; other site 331636001429 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 331636001430 anchoring element; other site 331636001431 dimer interface [polypeptide binding]; other site 331636001432 ATP binding site [chemical binding]; other site 331636001433 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 331636001434 active site 331636001435 putative metal-binding site [ion binding]; other site 331636001436 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 331636001437 DNA gyrase, A subunit; Region: gyrA; TIGR01063 331636001438 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 331636001439 CAP-like domain; other site 331636001440 active site 331636001441 primary dimer interface [polypeptide binding]; other site 331636001442 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 331636001443 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 331636001444 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 331636001445 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 331636001446 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 331636001447 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 331636001448 thymidylate kinase; Validated; Region: tmk; PRK00698 331636001449 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 331636001450 TMP-binding site; other site 331636001451 ATP-binding site [chemical binding]; other site 331636001452 DNA polymerase III subunit delta'; Validated; Region: PRK05917 331636001453 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 331636001454 Serine hydrolase (FSH1); Region: FSH1; pfam03959 331636001455 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 331636001456 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 331636001457 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 331636001458 active site 331636001459 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 331636001460 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 331636001461 HOOK protein; Region: HOOK; pfam05622 331636001462 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 331636001463 prenyltransferase; Reviewed; Region: ubiA; PRK12876 331636001464 UbiA prenyltransferase family; Region: UbiA; pfam01040 331636001465 aromatic acid decarboxylase; Validated; Region: PRK05920 331636001466 Flavoprotein; Region: Flavoprotein; pfam02441 331636001467 Uncharacterized conserved protein [Function unknown]; Region: COG1284 331636001468 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 331636001469 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 331636001470 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 331636001471 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 331636001472 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 331636001473 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 331636001474 Ligand Binding Site [chemical binding]; other site 331636001475 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 331636001476 SEC-C motif; Region: SEC-C; pfam02810 331636001477 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 331636001478 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 331636001479 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331636001480 FeS/SAM binding site; other site 331636001481 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 331636001482 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 331636001483 FtsX-like permease family; Region: FtsX; pfam02687 331636001484 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 331636001485 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 331636001486 Walker A/P-loop; other site 331636001487 ATP binding site [chemical binding]; other site 331636001488 Q-loop/lid; other site 331636001489 ABC transporter signature motif; other site 331636001490 Walker B; other site 331636001491 D-loop; other site 331636001492 H-loop/switch region; other site 331636001493 Protein of unknown function (DUF1389); Region: DUF1389; pfam07146 331636001494 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 331636001495 23S rRNA interface [nucleotide binding]; other site 331636001496 L3 interface [polypeptide binding]; other site 331636001497 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 331636001498 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 331636001499 NlpC/P60 family; Region: NLPC_P60; cl17555 331636001500 adenylate kinase; Reviewed; Region: adk; PRK00279 331636001501 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 331636001502 AMP-binding site [chemical binding]; other site 331636001503 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 331636001504 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 331636001505 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 331636001506 putative active site [active] 331636001507 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 331636001508 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 331636001509 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 331636001510 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 331636001511 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 331636001512 peptide binding site [polypeptide binding]; other site 331636001513 UGMP family protein; Validated; Region: PRK09604 331636001514 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 331636001515 arginine repressor; Region: argR_whole; TIGR01529 331636001516 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 331636001517 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 331636001518 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 331636001519 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331636001520 dimer interface [polypeptide binding]; other site 331636001521 conserved gate region; other site 331636001522 putative PBP binding loops; other site 331636001523 ABC-ATPase subunit interface; other site 331636001524 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 331636001525 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331636001526 Walker A/P-loop; other site 331636001527 ATP binding site [chemical binding]; other site 331636001528 Q-loop/lid; other site 331636001529 ABC transporter signature motif; other site 331636001530 Walker B; other site 331636001531 D-loop; other site 331636001532 H-loop/switch region; other site 331636001533 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 331636001534 Uncharacterized protein conserved in archaea (DUF2250); Region: DUF2250; pfam10007 331636001535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331636001536 Methyltransferase domain; Region: Methyltransf_31; pfam13847 331636001537 S-adenosylmethionine binding site [chemical binding]; other site 331636001538 IncA protein; Region: IncA; pfam04156 331636001539 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 331636001540 dimer interface [polypeptide binding]; other site 331636001541 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 331636001542 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 331636001543 substrate binding site [chemical binding]; other site 331636001544 hexamer interface [polypeptide binding]; other site 331636001545 metal binding site [ion binding]; metal-binding site 331636001546 elongation factor P; Provisional; Region: PRK12426 331636001547 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 331636001548 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 331636001549 RNA binding site [nucleotide binding]; other site 331636001550 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 331636001551 RNA binding site [nucleotide binding]; other site 331636001552 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 331636001553 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 331636001554 carboxyltransferase (CT) interaction site; other site 331636001555 biotinylation site [posttranslational modification]; other site 331636001556 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 331636001557 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 331636001558 ATP-grasp domain; Region: ATP-grasp_4; cl17255 331636001559 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 331636001560 Family of unknown function (DUF648); Region: DUF648; pfam04890 331636001561 Family of unknown function (DUF648); Region: DUF648; pfam04890 331636001562 Family of unknown function (DUF648); Region: DUF648; pfam04890 331636001563 Protein of unknown function (DUF1389); Region: DUF1389; pfam07146 331636001564 TcdB toxin N-terminal helical domain; Region: TcdB_N; pfam12918 331636001565 TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919 331636001566 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 331636001567 Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; cl04145 331636001568 Protein of unknown function (DUF3491); Region: DUF3491; pfam11996 331636001569 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 331636001570 membrane-attack complex / perforin; Region: MACPF; smart00457 331636001571 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 331636001572 Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443 331636001573 active site 331636001574 GMP synthase; Reviewed; Region: guaA; PRK00074 331636001575 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 331636001576 AMP/PPi binding site [chemical binding]; other site 331636001577 candidate oxyanion hole; other site 331636001578 catalytic triad [active] 331636001579 potential glutamine specificity residues [chemical binding]; other site 331636001580 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 331636001581 ATP Binding subdomain [chemical binding]; other site 331636001582 Ligand Binding sites [chemical binding]; other site 331636001583 Dimerization subdomain; other site 331636001584 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 331636001585 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 331636001586 active site 331636001587 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 331636001588 putative active site pocket [active] 331636001589 dimerization interface [polypeptide binding]; other site 331636001590 putative catalytic residue [active] 331636001591 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 331636001592 queuine tRNA-ribosyltransferase; Provisional; Region: PRK01008 331636001593 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 331636001594 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 331636001595 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 331636001596 Thioredoxin; Region: Thioredoxin_4; cl17273 331636001597 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729 331636001598 putative active site [active] 331636001599 redox center [active] 331636001600 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 331636001601 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331636001602 Walker A/P-loop; other site 331636001603 ATP binding site [chemical binding]; other site 331636001604 Q-loop/lid; other site 331636001605 ABC transporter signature motif; other site 331636001606 Walker B; other site 331636001607 D-loop; other site 331636001608 H-loop/switch region; other site 331636001609 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 331636001610 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 331636001611 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 331636001612 Ligand binding site; other site 331636001613 oligomer interface; other site 331636001614 CTP synthetase; Validated; Region: pyrG; PRK05380 331636001615 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 331636001616 Catalytic site [active] 331636001617 active site 331636001618 UTP binding site [chemical binding]; other site 331636001619 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 331636001620 active site 331636001621 putative oxyanion hole; other site 331636001622 catalytic triad [active] 331636001623 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 331636001624 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 331636001625 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 331636001626 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 331636001627 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 331636001628 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 331636001629 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 331636001630 peptide binding site [polypeptide binding]; other site 331636001631 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 331636001632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331636001633 dimer interface [polypeptide binding]; other site 331636001634 conserved gate region; other site 331636001635 putative PBP binding loops; other site 331636001636 ABC-ATPase subunit interface; other site 331636001637 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 331636001638 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 331636001639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331636001640 dimer interface [polypeptide binding]; other site 331636001641 conserved gate region; other site 331636001642 putative PBP binding loops; other site 331636001643 ABC-ATPase subunit interface; other site 331636001644 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 331636001645 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 331636001646 Walker A/P-loop; other site 331636001647 ATP binding site [chemical binding]; other site 331636001648 Q-loop/lid; other site 331636001649 ABC transporter signature motif; other site 331636001650 Walker B; other site 331636001651 D-loop; other site 331636001652 H-loop/switch region; other site 331636001653 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 331636001654 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 331636001655 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 331636001656 Walker A/P-loop; other site 331636001657 ATP binding site [chemical binding]; other site 331636001658 Q-loop/lid; other site 331636001659 ABC transporter signature motif; other site 331636001660 Walker B; other site 331636001661 D-loop; other site 331636001662 H-loop/switch region; other site 331636001663 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 331636001664 Protein of unknown function (DUF1186); Region: DUF1186; pfam06685 331636001665 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 331636001666 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 331636001667 transmembrane helices; other site 331636001668 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 331636001669 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 331636001670 active site 331636001671 ADP/pyrophosphate binding site [chemical binding]; other site 331636001672 dimerization interface [polypeptide binding]; other site 331636001673 allosteric effector site; other site 331636001674 fructose-1,6-bisphosphate binding site; other site 331636001675 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 331636001676 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 331636001677 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 331636001678 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 331636001679 active site 331636001680 ADP/pyrophosphate binding site [chemical binding]; other site 331636001681 dimerization interface [polypeptide binding]; other site 331636001682 allosteric effector site; other site 331636001683 fructose-1,6-bisphosphate binding site; other site 331636001684 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 331636001685 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 331636001686 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 331636001687 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 331636001688 HIGH motif; other site 331636001689 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 331636001690 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 331636001691 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 331636001692 active site 331636001693 KMSKS motif; other site 331636001694 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 331636001695 tRNA binding surface [nucleotide binding]; other site 331636001696 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 331636001697 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 331636001698 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 331636001699 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 331636001700 TrkA-N domain; Region: TrkA_N; pfam02254 331636001701 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 331636001702 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 331636001703 nucleotide binding pocket [chemical binding]; other site 331636001704 K-X-D-G motif; other site 331636001705 catalytic site [active] 331636001706 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 331636001707 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 331636001708 Helix-hairpin-helix motif; Region: HHH; pfam00633 331636001709 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 331636001710 Dimer interface [polypeptide binding]; other site 331636001711 BRCT sequence motif; other site 331636001712 Catalytic domain of Protein Kinases; Region: PKc; cd00180 331636001713 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 331636001714 active site 331636001715 ATP binding site [chemical binding]; other site 331636001716 substrate binding site [chemical binding]; other site 331636001717 activation loop (A-loop); other site 331636001718 Uncharacterized conserved protein [Function unknown]; Region: COG1262 331636001719 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 331636001720 IncA protein; Region: IncA; pfam04156 331636001721 Uncharacterized conserved protein [Function unknown]; Region: COG2912 331636001722 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 331636001723 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331636001724 TPR motif; other site 331636001725 binding surface 331636001726 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 331636001727 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 331636001728 Autotransporter beta-domain; Region: Autotransporter; pfam03797 331636001729 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 331636001730 Autotransporter beta-domain; Region: Autotransporter; pfam03797 331636001731 Chlamydial polymorphic outer membrane protein repeat; Region: POMP_repeat; TIGR01376 331636001732 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 331636001733 Autotransporter beta-domain; Region: Autotransporter; pfam03797 331636001734 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 331636001735 Clp amino terminal domain; Region: Clp_N; pfam02861 331636001736 Clp amino terminal domain; Region: Clp_N; pfam02861 331636001737 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331636001738 Walker A motif; other site 331636001739 ATP binding site [chemical binding]; other site 331636001740 Walker B motif; other site 331636001741 arginine finger; other site 331636001742 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331636001743 Walker A motif; other site 331636001744 ATP binding site [chemical binding]; other site 331636001745 Walker B motif; other site 331636001746 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 331636001747 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 331636001748 mce related protein; Region: MCE; pfam02470 331636001749 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 331636001750 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331636001751 Walker A/P-loop; other site 331636001752 ATP binding site [chemical binding]; other site 331636001753 Q-loop/lid; other site 331636001754 ABC transporter signature motif; other site 331636001755 Walker B; other site 331636001756 D-loop; other site 331636001757 H-loop/switch region; other site 331636001758 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 331636001759 Permease; Region: Permease; pfam02405 331636001760 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00615 331636001761 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 331636001762 inhibitor-cofactor binding pocket; inhibition site 331636001763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331636001764 catalytic residue [active] 331636001765 hypothetical protein; Validated; Region: PRK00228 331636001766 Uncharacterized conserved protein [Function unknown]; Region: COG1259 331636001767 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 331636001768 tetramer (dimer of dimers) interface [polypeptide binding]; other site 331636001769 active site 331636001770 dimer interface [polypeptide binding]; other site 331636001771 Protein of unknown function (DUF1389); Region: DUF1389; pfam07146 331636001772 Protein of unknown function (DUF1389); Region: DUF1389; pfam07146 331636001773 Protein of unknown function (DUF1389); Region: DUF1389; pfam07146 331636001774 Uncharacterized conserved protein [Function unknown]; Region: COG0327 331636001775 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 331636001776 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 331636001777 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 331636001778 active site 331636001779 Zn binding site [ion binding]; other site 331636001780 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 331636001781 oligomerisation interface [polypeptide binding]; other site 331636001782 mobile loop; other site 331636001783 roof hairpin; other site 331636001784 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 331636001785 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 331636001786 ring oligomerisation interface [polypeptide binding]; other site 331636001787 ATP/Mg binding site [chemical binding]; other site 331636001788 stacking interactions; other site 331636001789 hinge regions; other site 331636001790 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 331636001791 conserved cys residue [active] 331636001792 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 331636001793 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 331636001794 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331636001795 Walker A motif; other site 331636001796 ATP binding site [chemical binding]; other site 331636001797 Walker B motif; other site 331636001798 Family description; Region: UvrD_C_2; pfam13538 331636001799 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 331636001800 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 331636001801 active site 331636001802 HIGH motif; other site 331636001803 KMSKS motif; other site 331636001804 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 331636001805 tRNA binding surface [nucleotide binding]; other site 331636001806 anticodon binding site; other site 331636001807 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 331636001808 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 331636001809 catalytic site [active] 331636001810 G-X2-G-X-G-K; other site 331636001811 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 331636001812 RNA/DNA hybrid binding site [nucleotide binding]; other site 331636001813 active site 331636001814 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 331636001815 tRNA (guanine-N(1)-)-methyltransferase/unknown domain fusion protein; Reviewed; Region: trmD; PRK01037 331636001816 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 331636001817 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 331636001818 active site 331636001819 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14522 331636001820 signal recognition particle protein; Provisional; Region: PRK10867 331636001821 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 331636001822 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 331636001823 P loop; other site 331636001824 GTP binding site [chemical binding]; other site 331636001825 Signal peptide binding domain; Region: SRP_SPB; pfam02978 331636001826 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 331636001827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331636001828 S-adenosylmethionine binding site [chemical binding]; other site 331636001829 peptide chain release factor 1; Validated; Region: prfA; PRK00591 331636001830 PCRF domain; Region: PCRF; pfam03462 331636001831 RF-1 domain; Region: RF-1; pfam00472 331636001832 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 331636001833 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 331636001834 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 331636001835 Catalytic site [active] 331636001836 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 331636001837 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 331636001838 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 331636001839 HIGH motif; other site 331636001840 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 331636001841 active site 331636001842 KMSKS motif; other site 331636001843 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 331636001844 tRNA binding surface [nucleotide binding]; other site 331636001845 anticodon binding site; other site 331636001846 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 331636001847 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 331636001848 putative active site [active] 331636001849 PhoH-like protein; Region: PhoH; pfam02562 331636001850 Bacterial SH3 domain homologues; Region: SH3b; smart00287 331636001851 Bacterial SH3 domain homologues; Region: SH3b; smart00287 331636001852 BNR repeat-like domain; Region: BNR_2; pfam13088 331636001853 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 331636001854 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 331636001855 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 331636001856 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 331636001857 Uncharacterized conserved protein [Function unknown]; Region: COG1624 331636001858 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 331636001859 lipid A biosynthesis lauroyl acyltransferase; Provisional; Region: PRK05906 331636001860 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 331636001861 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 331636001862 putative acyl-acceptor binding pocket; other site 331636001863 pyruvate kinase; Provisional; Region: PRK05826 331636001864 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 331636001865 domain interfaces; other site 331636001866 active site 331636001867 excinuclease ABC subunit A; Provisional; Region: PRK00635 331636001868 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331636001869 Walker A/P-loop; other site 331636001870 ATP binding site [chemical binding]; other site 331636001871 Q-loop/lid; other site 331636001872 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 331636001873 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 331636001874 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331636001875 Walker A/P-loop; other site 331636001876 ATP binding site [chemical binding]; other site 331636001877 Q-loop/lid; other site 331636001878 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331636001879 ATP binding site [chemical binding]; other site 331636001880 Q-loop/lid; other site 331636001881 ABC transporter signature motif; other site 331636001882 Walker B; other site 331636001883 D-loop; other site 331636001884 H-loop/switch region; other site 331636001885 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331636001886 Walker A/P-loop; other site 331636001887 ATP binding site [chemical binding]; other site 331636001888 Q-loop/lid; other site 331636001889 ABC transporter signature motif; other site 331636001890 Walker B; other site 331636001891 D-loop; other site 331636001892 H-loop/switch region; other site 331636001893 serine/threonine-protein kinase; Reviewed; Region: pknD; PRK13184 331636001894 Catalytic domain of Protein Kinases; Region: PKc; cd00180 331636001895 active site 331636001896 ATP binding site [chemical binding]; other site 331636001897 substrate binding site [chemical binding]; other site 331636001898 activation loop (A-loop); other site 331636001899 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 331636001900 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 331636001901 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 331636001902 active site 331636001903 HIGH motif; other site 331636001904 nucleotide binding site [chemical binding]; other site 331636001905 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 331636001906 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 331636001907 active site 331636001908 KMSKS motif; other site 331636001909 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 331636001910 tRNA binding surface [nucleotide binding]; other site 331636001911 anticodon binding site; other site 331636001912 V-type ATP synthase subunit K; Provisional; Region: PRK09621 331636001913 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 331636001914 V-type ATP synthase subunit I; Validated; Region: PRK05771 331636001915 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 331636001916 V-type ATP synthase subunit D; Provisional; Region: PRK02195 331636001917 V-type ATP synthase subunit B; Provisional; Region: PRK02118 331636001918 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 331636001919 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 331636001920 Walker A motif homologous position; other site 331636001921 Walker B motif; other site 331636001922 V-type ATP synthase subunit A; Provisional; Region: PRK04192 331636001923 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 331636001924 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 331636001925 Walker A motif/ATP binding site; other site 331636001926 Walker B motif; other site 331636001927 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 331636001928 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 331636001929 V-type ATP synthase subunit E; Provisional; Region: PRK01005 331636001930 V-type ATP synthase subunit E; Provisional; Region: PRK01558 331636001931 transaldolase-like protein; Provisional; Region: PTZ00411 331636001932 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 331636001933 active site 331636001934 dimer interface [polypeptide binding]; other site 331636001935 catalytic residue [active] 331636001936 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 331636001937 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 331636001938 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 331636001939 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 331636001940 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 331636001941 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 331636001942 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 331636001943 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 331636001944 DNA binding site [nucleotide binding] 331636001945 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 331636001946 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 331636001947 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 331636001948 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 331636001949 DNA-directed RNA polymerase, beta subunit; Region: rpoB; TIGR02013 331636001950 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 331636001951 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 331636001952 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 331636001953 RPB3 interaction site [polypeptide binding]; other site 331636001954 RPB1 interaction site [polypeptide binding]; other site 331636001955 RPB11 interaction site [polypeptide binding]; other site 331636001956 RPB10 interaction site [polypeptide binding]; other site 331636001957 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 331636001958 L11 interface [polypeptide binding]; other site 331636001959 putative EF-Tu interaction site [polypeptide binding]; other site 331636001960 putative EF-G interaction site [polypeptide binding]; other site 331636001961 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 331636001962 23S rRNA interface [nucleotide binding]; other site 331636001963 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 331636001964 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 331636001965 mRNA/rRNA interface [nucleotide binding]; other site 331636001966 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 331636001967 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 331636001968 23S rRNA interface [nucleotide binding]; other site 331636001969 L7/L12 interface [polypeptide binding]; other site 331636001970 putative thiostrepton binding site; other site 331636001971 L25 interface [polypeptide binding]; other site 331636001972 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 331636001973 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 331636001974 putative homodimer interface [polypeptide binding]; other site 331636001975 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 331636001976 heterodimer interface [polypeptide binding]; other site 331636001977 homodimer interface [polypeptide binding]; other site 331636001978 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 331636001979 elongation factor Tu; Reviewed; Region: PRK12735 331636001980 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 331636001981 G1 box; other site 331636001982 GEF interaction site [polypeptide binding]; other site 331636001983 GTP/Mg2+ binding site [chemical binding]; other site 331636001984 Switch I region; other site 331636001985 G2 box; other site 331636001986 G3 box; other site 331636001987 Switch II region; other site 331636001988 G4 box; other site 331636001989 G5 box; other site 331636001990 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 331636001991 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 331636001992 Antibiotic Binding Site [chemical binding]; other site 331636001993 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 331636001994 rRNA binding site [nucleotide binding]; other site 331636001995 predicted 30S ribosome binding site; other site 331636001996 Fe-S metabolism associated domain; Region: SufE; cl00951 331636001997 BioY family; Region: BioY; pfam02632 331636001998 Protein of unknown function (DUF687); Region: DUF687; pfam05095 331636001999 dihydrodipicolinate synthase; Region: dapA; TIGR00674 331636002000 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 331636002001 dimer interface [polypeptide binding]; other site 331636002002 active site 331636002003 catalytic residue [active] 331636002004 aspartate kinase; Provisional; Region: PRK05925 331636002005 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 331636002006 putative catalytic residues [active] 331636002007 nucleotide binding site [chemical binding]; other site 331636002008 aspartate binding site [chemical binding]; other site 331636002009 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 331636002010 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 331636002011 dihydrodipicolinate reductase; Provisional; Region: PRK00048 331636002012 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 331636002013 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 331636002014 phenylalanine 4-monooxygenase; Reviewed; Region: phhA; PRK11913 331636002015 cofactor binding site; other site 331636002016 metal binding site [ion binding]; metal-binding site 331636002017 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 331636002018 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784 331636002019 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331636002020 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 331636002021 NAD(P) binding site [chemical binding]; other site 331636002022 active site 331636002023 biotin synthase; Region: bioB; TIGR00433 331636002024 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331636002025 FeS/SAM binding site; other site 331636002026 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 331636002027 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 331636002028 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 331636002029 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 331636002030 catalytic residue [active] 331636002031 AAA domain; Region: AAA_26; pfam13500 331636002032 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 331636002033 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 331636002034 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 331636002035 inhibitor-cofactor binding pocket; inhibition site 331636002036 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331636002037 catalytic residue [active] 331636002038 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 331636002039 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 331636002040 hinge; other site 331636002041 active site 331636002042 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 331636002043 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 331636002044 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 331636002045 Tetramer interface [polypeptide binding]; other site 331636002046 active site 331636002047 FMN-binding site [chemical binding]; other site 331636002048 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 331636002049 active site 331636002050 dimer interface [polypeptide binding]; other site 331636002051 metal binding site [ion binding]; metal-binding site 331636002052 bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase protein; Reviewed; Region: aroDE; PRK09310 331636002053 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 331636002054 active site 331636002055 catalytic residue [active] 331636002056 dimer interface [polypeptide binding]; other site 331636002057 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 331636002058 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 331636002059 shikimate binding site; other site 331636002060 NAD(P) binding site [chemical binding]; other site 331636002061 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 331636002062 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 331636002063 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) [Amino acid transport and metabolism]; Region: COG1945 331636002064 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 331636002065 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 331636002066 malate dehydrogenase; Provisional; Region: PRK05442 331636002067 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 331636002068 NAD(P) binding site [chemical binding]; other site 331636002069 LDH/MDH dimer interface [polypeptide binding]; other site 331636002070 substrate binding site [chemical binding]; other site 331636002071 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 331636002072 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 331636002073 active site 331636002074 dimer interface [polypeptide binding]; other site 331636002075 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 331636002076 dimer interface [polypeptide binding]; other site 331636002077 active site 331636002078 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 331636002079 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 331636002080 active site 331636002081 DNA binding site [nucleotide binding] 331636002082 Int/Topo IB signature motif; other site 331636002083 Protein of unknown function (DUF342); Region: DUF342; pfam03961 331636002084 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 331636002085 Histone methylation protein DOT1; Region: DOT1; pfam08123 331636002086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331636002087 S-adenosylmethionine binding site [chemical binding]; other site 331636002088 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 331636002089 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 331636002090 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 331636002091 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 331636002092 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 331636002093 Active site serine [active] 331636002094 Na+/H+ antiporter, NhaD family; Region: NhaD; TIGR00775 331636002095 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 331636002096 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 331636002097 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 331636002098 Sulfate transporter family; Region: Sulfate_transp; pfam00916 331636002099 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 331636002100 fumarate hydratase; Reviewed; Region: fumC; PRK00485 331636002101 Class II fumarases; Region: Fumarase_classII; cd01362 331636002102 active site 331636002103 tetramer interface [polypeptide binding]; other site 331636002104 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 331636002105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331636002106 dimer interface [polypeptide binding]; other site 331636002107 conserved gate region; other site 331636002108 putative PBP binding loops; other site 331636002109 ABC-ATPase subunit interface; other site 331636002110 NMT1/THI5 like; Region: NMT1; pfam09084 331636002111 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 331636002112 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 331636002113 methionine aminopeptidase; Provisional; Region: PRK12318 331636002114 SEC-C motif; Region: SEC-C; pfam02810 331636002115 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 331636002116 active site 331636002117 Protein of unknown function (DUF720); Region: DUF720; pfam05302 331636002118 Protein of unknown function (DUF720); Region: DUF720; pfam05302 331636002119 Protein of unknown function (DUF720); Region: DUF720; pfam05302 331636002120 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 331636002121 nucleoside/Zn binding site; other site 331636002122 dimer interface [polypeptide binding]; other site 331636002123 catalytic motif [active] 331636002124 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 331636002125 16S/18S rRNA binding site [nucleotide binding]; other site 331636002126 S13e-L30e interaction site [polypeptide binding]; other site 331636002127 25S rRNA binding site [nucleotide binding]; other site 331636002128 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 331636002129 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 331636002130 RNase E interface [polypeptide binding]; other site 331636002131 trimer interface [polypeptide binding]; other site 331636002132 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 331636002133 RNase E interface [polypeptide binding]; other site 331636002134 trimer interface [polypeptide binding]; other site 331636002135 active site 331636002136 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 331636002137 putative nucleic acid binding region [nucleotide binding]; other site 331636002138 G-X-X-G motif; other site 331636002139 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 331636002140 RNA binding site [nucleotide binding]; other site 331636002141 domain interface; other site 331636002142 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 331636002143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331636002144 Walker A motif; other site 331636002145 ATP binding site [chemical binding]; other site 331636002146 Walker B motif; other site 331636002147 arginine finger; other site 331636002148 Peptidase family M41; Region: Peptidase_M41; pfam01434 331636002149 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 331636002150 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 331636002151 Ligand Binding Site [chemical binding]; other site 331636002152 Predicted permeases [General function prediction only]; Region: COG0795 331636002153 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 331636002154 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 331636002155 Predicted permeases [General function prediction only]; Region: COG0795 331636002156 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 331636002157 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 331636002158 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 331636002159 motif 1; other site 331636002160 dimer interface [polypeptide binding]; other site 331636002161 active site 331636002162 motif 2; other site 331636002163 motif 3; other site 331636002164 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 331636002165 23S rRNA binding site [nucleotide binding]; other site 331636002166 L21 binding site [polypeptide binding]; other site 331636002167 L13 binding site [polypeptide binding]; other site 331636002168 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 331636002169 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 331636002170 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 331636002171 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 331636002172 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 331636002173 putative RNA binding site [nucleotide binding]; other site 331636002174 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 331636002175 FAD binding domain; Region: FAD_binding_4; pfam01565 331636002176 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 331636002177 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 331636002178 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 331636002179 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 331636002180 dimer interface [polypeptide binding]; other site 331636002181 putative radical transfer pathway; other site 331636002182 diiron center [ion binding]; other site 331636002183 tyrosyl radical; other site 331636002184 ribonucleotide-diphosphate reductase subunit alpha; Provisional; Region: PRK12365 331636002185 ATP cone domain; Region: ATP-cone; pfam03477 331636002186 ATP cone domain; Region: ATP-cone; pfam03477 331636002187 ATP cone domain; Region: ATP-cone; pfam03477 331636002188 Class I ribonucleotide reductase; Region: RNR_I; cd01679 331636002189 active site 331636002190 dimer interface [polypeptide binding]; other site 331636002191 catalytic residues [active] 331636002192 effector binding site; other site 331636002193 R2 peptide binding site; other site 331636002194 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 331636002195 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 331636002196 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 331636002197 RmuC family; Region: RmuC; pfam02646 331636002198 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 331636002199 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 331636002200 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 331636002201 Peptidase M16C associated; Region: M16C_assoc; pfam08367 331636002202 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 331636002203 hypothetical protein; Provisional; Region: PRK08201 331636002204 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 331636002205 metal binding site [ion binding]; metal-binding site 331636002206 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 331636002207 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 331636002208 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 331636002209 protein binding site [polypeptide binding]; other site 331636002210 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 331636002211 protein binding site [polypeptide binding]; other site 331636002212 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 331636002213 CoA binding domain; Region: CoA_binding; smart00881 331636002214 CoA-ligase; Region: Ligase_CoA; pfam00549 331636002215 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 331636002216 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 331636002217 CoA-ligase; Region: Ligase_CoA; pfam00549 331636002218 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 331636002219 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 331636002220 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 331636002221 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 331636002222 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 331636002223 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 331636002224 aromatic amino acid transport protein; Region: araaP; TIGR00837 331636002225 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 331636002226 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 331636002227 glutaminase active site [active] 331636002228 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 331636002229 dimer interface [polypeptide binding]; other site 331636002230 active site 331636002231 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 331636002232 dimer interface [polypeptide binding]; other site 331636002233 active site 331636002234 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 331636002235 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 331636002236 active site 331636002237 substrate binding site [chemical binding]; other site 331636002238 metal binding site [ion binding]; metal-binding site 331636002239 poly(A) polymerase; Region: pcnB; TIGR01942 331636002240 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 331636002241 active site 331636002242 NTP binding site [chemical binding]; other site 331636002243 metal binding triad [ion binding]; metal-binding site 331636002244 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 331636002245 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK01021 331636002246 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578 331636002247 Predicted membrane protein [Function unknown]; Region: COG3952 331636002248 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 331636002249 IncA protein; Region: IncA; pfam04156 331636002250 IncA protein; Region: IncA; pfam04156 331636002251 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 331636002252 IncA protein; Region: IncA; pfam04156 331636002253 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 331636002254 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 331636002255 IncA protein; Region: IncA; pfam04156 331636002256 IncA protein; Region: IncA; pfam04156 331636002257 Domain of Unknown Function (DUF1539); Region: DUF1539; pfam07560 331636002258 Domain of Unknown Function (DUF1548); Region: DUF1548; pfam07579 331636002259 Domain of Unknown Function (DUF1539); Region: DUF1539; pfam07560 331636002260 Domain of Unknown Function (DUF1539); Region: DUF1539; pfam07560 331636002261 Domain of Unknown Function (DUF1548); Region: DUF1548; pfam07579 331636002262 Domain of Unknown Function (DUF1539); Region: DUF1539; pfam07560 331636002263 Domain of Unknown Function (DUF1548); Region: DUF1548; pfam07579 331636002264 Chlamydia polymorphic membrane protein middle domain; Region: ChlamPMP_M; pfam07548 331636002265 Autotransporter beta-domain; Region: Autotransporter; pfam03797 331636002266 putative glycerol-3-phosphate acyltransferase PlsX; Provisional; Region: PRK13846 331636002267 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 331636002268 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 331636002269 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 331636002270 homodimer interface [polypeptide binding]; other site 331636002271 oligonucleotide binding site [chemical binding]; other site 331636002272 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT; Region: LPLAT_GPAT; cd07985 331636002273 putative G3P-binding pocket; other site 331636002274 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 331636002275 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 331636002276 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 331636002277 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 331636002278 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 331636002279 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK00650 331636002280 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 331636002281 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 331636002282 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 331636002283 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 331636002284 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 331636002285 Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Region: RpsF; COG0360 331636002286 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 331636002287 putative active site [active] 331636002288 catalytic residue [active] 331636002289 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 331636002290 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 331636002291 5S rRNA interface [nucleotide binding]; other site 331636002292 CTC domain interface [polypeptide binding]; other site 331636002293 L16 interface [polypeptide binding]; other site 331636002294 glycogen synthase; Provisional; Region: glgA; PRK00654 331636002295 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 331636002296 ADP-binding pocket [chemical binding]; other site 331636002297 homodimer interface [polypeptide binding]; other site 331636002298 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 331636002299 glycyl-tRNA synthetase; Provisional; Region: PRK14908 331636002300 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 331636002301 dimer interface [polypeptide binding]; other site 331636002302 motif 1; other site 331636002303 active site 331636002304 motif 2; other site 331636002305 motif 3; other site 331636002306 DNA primase; Validated; Region: dnaG; PRK05667 331636002307 CHC2 zinc finger; Region: zf-CHC2; pfam01807 331636002308 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 331636002309 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 331636002310 active site 331636002311 metal binding site [ion binding]; metal-binding site 331636002312 interdomain interaction site; other site 331636002313 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 331636002314 MutS domain I; Region: MutS_I; pfam01624 331636002315 MutS domain II; Region: MutS_II; pfam05188 331636002316 MutS domain III; Region: MutS_III; pfam05192 331636002317 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 331636002318 Walker A/P-loop; other site 331636002319 ATP binding site [chemical binding]; other site 331636002320 Q-loop/lid; other site 331636002321 ABC transporter signature motif; other site 331636002322 Walker B; other site 331636002323 D-loop; other site 331636002324 H-loop/switch region; other site 331636002325 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 331636002326 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 331636002327 active site 331636002328 catalytic site [active] 331636002329 putative DNA binding site [nucleotide binding]; other site 331636002330 GIY-YIG motif/motif A; other site 331636002331 metal binding site [ion binding]; metal-binding site 331636002332 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 331636002333 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 331636002334 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 331636002335 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 331636002336 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 331636002337 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 331636002338 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 331636002339 active site 331636002340 HIGH motif; other site 331636002341 nucleotide binding site [chemical binding]; other site 331636002342 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 331636002343 KMSKS motif; other site 331636002344 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 331636002345 tRNA binding surface [nucleotide binding]; other site 331636002346 anticodon binding site; other site 331636002347 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 331636002348 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 331636002349 dimer interface [polypeptide binding]; other site 331636002350 putative anticodon binding site; other site 331636002351 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 331636002352 motif 1; other site 331636002353 dimer interface [polypeptide binding]; other site 331636002354 active site 331636002355 motif 2; other site 331636002356 motif 3; other site 331636002357 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 331636002358 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 331636002359 primosome assembly protein PriA; Validated; Region: PRK05580 331636002360 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 331636002361 ATP binding site [chemical binding]; other site 331636002362 putative Mg++ binding site [ion binding]; other site 331636002363 helicase superfamily c-terminal domain; Region: HELICc; smart00490 331636002364 ATP-binding site [chemical binding]; other site 331636002365 long chain fatty acid--[acyl-carrier-protein] ligase; Validated; Region: PRK06334 331636002366 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 331636002367 acyl-activating enzyme (AAE) consensus motif; other site 331636002368 AMP binding site [chemical binding]; other site 331636002369 active site 331636002370 CoA binding site [chemical binding]; other site 331636002371 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 331636002372 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 331636002373 putative acyl-acceptor binding pocket; other site 331636002374 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 331636002375 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 331636002376 active site 331636002377 putative lithium-binding site [ion binding]; other site 331636002378 substrate binding site [chemical binding]; other site 331636002379 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 331636002380 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 331636002381 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 331636002382 NAD binding site [chemical binding]; other site 331636002383 Phe binding site; other site 331636002384 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 331636002385 dimer interface [polypeptide binding]; other site 331636002386 substrate binding site [chemical binding]; other site 331636002387 metal binding sites [ion binding]; metal-binding site 331636002388 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 331636002389 active site 331636002390 Ap4A binding cleft/pocket [chemical binding]; other site 331636002391 P4 phosphate binding site; other site 331636002392 nudix motif; other site 331636002393 putative P2/P3 phosphate binding site [ion binding]; other site 331636002394 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 331636002395 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 331636002396 dimer interface [polypeptide binding]; other site 331636002397 active site 331636002398 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 331636002399 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 331636002400 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 331636002401 hypothetical protein; Provisional; Region: PRK05927 331636002402 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 331636002403 FeS/SAM binding site; other site 331636002404 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 331636002405 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 331636002406 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 331636002407 anti sigma factor interaction site; other site 331636002408 regulatory phosphorylation site [posttranslational modification]; other site 331636002409 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 331636002410 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 331636002411 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cd02409 331636002412 G-X-X-G motif; other site 331636002413 bifunctional D-alanyl-alanine synthetase A/UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: PRK14573 331636002414 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 331636002415 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 331636002416 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 331636002417 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 331636002418 ATP-grasp domain; Region: ATP-grasp_4; cl17255 331636002419 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 331636002420 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 331636002421 homodimer interface [polypeptide binding]; other site 331636002422 active site 331636002423 cell division protein FtsW; Region: ftsW; TIGR02614 331636002424 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 331636002425 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 331636002426 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK00683 331636002427 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 331636002428 NAD(P) binding site [chemical binding]; other site 331636002429 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331636002430 Walker A/P-loop; other site 331636002431 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 331636002432 ATP binding site [chemical binding]; other site 331636002433 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 331636002434 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 331636002435 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 331636002436 Mg++ binding site [ion binding]; other site 331636002437 putative catalytic motif [active] 331636002438 putative substrate binding site [chemical binding]; other site 331636002439 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 331636002440 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 331636002441 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 331636002442 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 331636002443 chaperonin GroL; Region: GroEL; TIGR02348 331636002444 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 331636002445 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 331636002446 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 331636002447 active site 331636002448 metal binding site [ion binding]; metal-binding site 331636002449 elongation factor P; Validated; Region: PRK00529 331636002450 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 331636002451 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 331636002452 RNA binding site [nucleotide binding]; other site 331636002453 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 331636002454 RNA binding site [nucleotide binding]; other site 331636002455 AMP nucleosidase; Provisional; Region: PRK07115 331636002456 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 331636002457 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 331636002458 TPP-binding site [chemical binding]; other site 331636002459 dimer interface [polypeptide binding]; other site 331636002460 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 331636002461 PYR/PP interface [polypeptide binding]; other site 331636002462 dimer interface [polypeptide binding]; other site 331636002463 TPP binding site [chemical binding]; other site 331636002464 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 331636002465 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 331636002466 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 331636002467 motif 1; other site 331636002468 active site 331636002469 motif 2; other site 331636002470 motif 3; other site 331636002471 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 331636002472 DHHA1 domain; Region: DHHA1; pfam02272 331636002473 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 331636002474 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 331636002475 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 331636002476 ATP binding site [chemical binding]; other site 331636002477 putative Mg++ binding site [ion binding]; other site 331636002478 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 331636002479 nucleotide binding region [chemical binding]; other site 331636002480 ATP-binding site [chemical binding]; other site 331636002481 TRCF domain; Region: TRCF; pfam03461 331636002482 uroporphyrinogen decarboxylase; Validated; Region: hemE; PRK00115 331636002483 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 331636002484 HemN C-terminal domain; Region: HemN_C; pfam06969 331636002485 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 331636002486 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 331636002487 Histone H1-like protein Hc1; Region: Hc1; pfam07432 331636002488 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 331636002489 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331636002490 S-adenosylmethionine binding site [chemical binding]; other site 331636002491 preprotein translocase, YajC subunit; Region: yajC; TIGR00739 331636002492 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 331636002493 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 331636002494 catalytic loop [active] 331636002495 iron binding site [ion binding]; other site 331636002496 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 331636002497 FAD binding pocket [chemical binding]; other site 331636002498 FAD binding motif [chemical binding]; other site 331636002499 phosphate binding motif [ion binding]; other site 331636002500 beta-alpha-beta structure motif; other site 331636002501 NAD binding pocket [chemical binding]; other site 331636002502 Protein of unknown function (DUF687); Region: DUF687; pfam05095 331636002503 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 331636002504 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 331636002505 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 331636002506 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 331636002507 Proteins containing SET domain [General function prediction only]; Region: COG2940 331636002508 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 331636002509 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 331636002510 substrate binding site [chemical binding]; other site 331636002511 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 331636002512 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 331636002513 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 331636002514 homopentamer interface [polypeptide binding]; other site 331636002515 active site 331636002516 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 331636002517 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 331636002518 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 331636002519 dimerization interface [polypeptide binding]; other site 331636002520 active site 331636002521 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 331636002522 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 331636002523 catalytic motif [active] 331636002524 Zn binding site [ion binding]; other site 331636002525 RibD C-terminal domain; Region: RibD_C; pfam01872 331636002526 seryl-tRNA synthetase; Provisional; Region: PRK05431 331636002527 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 331636002528 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 331636002529 dimer interface [polypeptide binding]; other site 331636002530 active site 331636002531 motif 1; other site 331636002532 motif 2; other site 331636002533 motif 3; other site 331636002534 CCC1-related protein family; Region: CCC1_like_1; cd02437 331636002535 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 331636002536 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 331636002537 Soluble P-type ATPase [General function prediction only]; Region: COG4087 331636002538 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 331636002539 biotin--protein ligase; Provisional; Region: PRK05935 331636002540 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 331636002541 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 331636002542 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 331636002543 RNA binding surface [nucleotide binding]; other site 331636002544 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 331636002545 active site 331636002546 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 331636002547 catalytic core [active] 331636002548 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 331636002549 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 331636002550 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 331636002551 catalytic residue [active] 331636002552 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 331636002553 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 331636002554 NifU-like domain; Region: NifU; cl00484 331636002555 type III secretion system protein; Validated; Region: PRK05934 331636002556 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 331636002557 MgtE intracellular N domain; Region: MgtE_N; cl15244 331636002558 flagellar assembly protein H; Validated; Region: fliH; PRK06669 331636002559 type III secretion system ATPase; Validated; Region: PRK05922 331636002560 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 331636002561 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 331636002562 Walker A motif; other site 331636002563 ATP binding site [chemical binding]; other site 331636002564 Walker B motif; other site 331636002565 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 331636002566 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 331636002567 substrate binding site; other site 331636002568 dimerization interface; other site 331636002569 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 331636002570 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 331636002571 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 331636002572 Chlamydia major outer membrane protein; Region: Chlam_OMP; pfam01308 331636002573 Effector from type III secretion system; Region: Effector_1; pfam04518 331636002574 Effector from type III secretion system; Region: Effector_1; pfam04518 331636002575 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 331636002576 active site 331636002577 substrate-binding site [chemical binding]; other site 331636002578 metal-binding site [ion binding] 331636002579 GTP binding site [chemical binding]; other site 331636002580 rod shape-determining protein MreB; Provisional; Region: PRK13927 331636002581 MreB and similar proteins; Region: MreB_like; cd10225 331636002582 nucleotide binding site [chemical binding]; other site 331636002583 Mg binding site [ion binding]; other site 331636002584 putative protofilament interaction site [polypeptide binding]; other site 331636002585 RodZ interaction site [polypeptide binding]; other site 331636002586 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 331636002587 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 331636002588 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 331636002589 ATP binding site [chemical binding]; other site 331636002590 putative Mg++ binding site [ion binding]; other site 331636002591 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 331636002592 nucleotide binding region [chemical binding]; other site 331636002593 ATP-binding site [chemical binding]; other site 331636002594 trigger factor; Provisional; Region: tig; PRK01490 331636002595 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 331636002596 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 331636002597 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 331636002598 oligomer interface [polypeptide binding]; other site 331636002599 active site residues [active] 331636002600 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 331636002601 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 331636002602 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331636002603 Walker A motif; other site 331636002604 ATP binding site [chemical binding]; other site 331636002605 Walker B motif; other site 331636002606 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 331636002607 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 331636002608 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 331636002609 active site 331636002610 NTP binding site [chemical binding]; other site 331636002611 metal binding triad [ion binding]; metal-binding site 331636002612 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 331636002613 GTP-binding protein Der; Reviewed; Region: PRK00093 331636002614 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 331636002615 G1 box; other site 331636002616 GTP/Mg2+ binding site [chemical binding]; other site 331636002617 Switch I region; other site 331636002618 G2 box; other site 331636002619 Switch II region; other site 331636002620 G3 box; other site 331636002621 G4 box; other site 331636002622 G5 box; other site 331636002623 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 331636002624 G1 box; other site 331636002625 GTP/Mg2+ binding site [chemical binding]; other site 331636002626 Switch I region; other site 331636002627 G2 box; other site 331636002628 G3 box; other site 331636002629 Switch II region; other site 331636002630 G4 box; other site 331636002631 G5 box; other site 331636002632 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12899 331636002633 DEAD/DEAH box helicase; Region: DEAD; pfam00270 331636002634 ATP binding site [chemical binding]; other site 331636002635 putative Mg++ binding site [ion binding]; other site 331636002636 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 331636002637 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 331636002638 nucleotide binding region [chemical binding]; other site 331636002639 ATP-binding site [chemical binding]; other site 331636002640 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 331636002641 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331636002642 binding surface 331636002643 TPR motif; other site 331636002644 phosphatidylserine decarboxylase; Provisional; Region: PRK00723 331636002645 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 331636002646 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 331636002647 trmE is a tRNA modification GTPase; Region: trmE; cd04164 331636002648 G1 box; other site 331636002649 GTP/Mg2+ binding site [chemical binding]; other site 331636002650 Switch I region; other site 331636002651 G2 box; other site 331636002652 Switch II region; other site 331636002653 G3 box; other site 331636002654 G4 box; other site 331636002655 G5 box; other site 331636002656 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 331636002657 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 331636002658 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 331636002659 minor groove reading motif; other site 331636002660 helix-hairpin-helix signature motif; other site 331636002661 substrate binding pocket [chemical binding]; other site 331636002662 active site 331636002663 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 331636002664 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 331636002665 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 331636002666 ATP binding site [chemical binding]; other site 331636002667 putative Mg++ binding site [ion binding]; other site 331636002668 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 331636002669 nucleotide binding region [chemical binding]; other site 331636002670 ATP-binding site [chemical binding]; other site 331636002671 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 331636002672 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 331636002673 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331636002674 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 331636002675 lipoyl synthase; Provisional; Region: PRK05481 331636002676 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331636002677 FeS/SAM binding site; other site 331636002678 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 331636002679 type III secretion system protein; Validated; Region: PRK06328 331636002680 Flagellar assembly protein FliH; Region: FliH; pfam02108 331636002681 FliP family; Region: FliP; cl00593 331636002682 type III secretion system protein; Reviewed; Region: PRK09617 331636002683 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 331636002684 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 331636002685 Protein of unknown function (DUF1494); Region: DUF1494; pfam07379 331636002686 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 331636002687 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 331636002688 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 331636002689 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 331636002690 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 331636002691 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 331636002692 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 331636002693 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 331636002694 Walker A motif; other site 331636002695 ATP binding site [chemical binding]; other site 331636002696 Walker B motif; other site 331636002697 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 331636002698 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 331636002699 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 331636002700 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 331636002701 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 331636002702 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 331636002703 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 331636002704 active site 331636002705 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 331636002706 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331636002707 ATP binding site [chemical binding]; other site 331636002708 Mg2+ binding site [ion binding]; other site 331636002709 G-X-G motif; other site 331636002710 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 331636002711 ATP binding site [chemical binding]; other site 331636002712 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 331636002713 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 331636002714 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331636002715 binding surface 331636002716 TPR motif; other site 331636002717 pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362 331636002718 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 331636002719 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 331636002720 EamA-like transporter family; Region: EamA; pfam00892 331636002721 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 331636002722 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cd01616 331636002723 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 331636002724 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 331636002725 active site 331636002726 dimer interface [polypeptide binding]; other site 331636002727 motif 1; other site 331636002728 motif 2; other site 331636002729 motif 3; other site 331636002730 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 331636002731 anticodon binding site; other site 331636002732 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 331636002733 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 331636002734 Uncharacterized protein family (UPF0137); Region: UPF0137; pfam03677 331636002735 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 331636002736 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 331636002737 active site 331636002738 HIGH motif; other site 331636002739 dimer interface [polypeptide binding]; other site 331636002740 KMSKS motif; other site 331636002741 excinuclease ABC subunit B; Provisional; Region: PRK05298 331636002742 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 331636002743 ATP binding site [chemical binding]; other site 331636002744 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 331636002745 nucleotide binding region [chemical binding]; other site 331636002746 ATP-binding site [chemical binding]; other site 331636002747 Ultra-violet resistance protein B; Region: UvrB; pfam12344 331636002748 UvrB/uvrC motif; Region: UVR; pfam02151 331636002749 enolase; Provisional; Region: eno; PRK00077 331636002750 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 331636002751 dimer interface [polypeptide binding]; other site 331636002752 metal binding site [ion binding]; metal-binding site 331636002753 substrate binding pocket [chemical binding]; other site 331636002754 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 331636002755 HAMP domain; Region: HAMP; pfam00672 331636002756 dimerization interface [polypeptide binding]; other site 331636002757 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 331636002758 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 331636002759 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 331636002760 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 331636002761 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 331636002762 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 331636002763 L-aspartate oxidase; Provisional; Region: PRK06175 331636002764 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 331636002765 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 331636002766 putative Iron-sulfur protein interface [polypeptide binding]; other site 331636002767 proximal heme binding site [chemical binding]; other site 331636002768 distal heme binding site [chemical binding]; other site 331636002769 putative dimer interface [polypeptide binding]; other site 331636002770 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 331636002771 active site 331636002772 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 331636002773 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 331636002774 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 331636002775 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 331636002776 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 331636002777 DsbD alpha interface [polypeptide binding]; other site 331636002778 catalytic residues [active] 331636002779 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 331636002780 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 331636002781 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 331636002782 translocation protein TolB; Provisional; Region: tolB; PRK01029 331636002783 TolB amino-terminal domain; Region: TolB_N; pfam04052 331636002784 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 331636002785 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 331636002786 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 331636002787 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 331636002788 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 331636002789 ligand binding site [chemical binding]; other site 331636002790 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 331636002791 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 331636002792 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 331636002793 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 331636002794 dimer interface [polypeptide binding]; other site 331636002795 decamer (pentamer of dimers) interface [polypeptide binding]; other site 331636002796 catalytic triad [active] 331636002797 peroxidatic and resolving cysteines [active] 331636002798 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 331636002799 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 331636002800 ring oligomerisation interface [polypeptide binding]; other site 331636002801 ATP/Mg binding site [chemical binding]; other site 331636002802 stacking interactions; other site 331636002803 hinge regions; other site 331636002804 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 331636002805 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 331636002806 active site 331636002807 dimerization interface [polypeptide binding]; other site 331636002808 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 331636002809 ligand binding site [chemical binding]; other site 331636002810 active site 331636002811 UGI interface [polypeptide binding]; other site 331636002812 catalytic site [active] 331636002813 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 331636002814 Part of AAA domain; Region: AAA_19; pfam13245 331636002815 Family description; Region: UvrD_C_2; pfam13538 331636002816 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 331636002817 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 331636002818 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 331636002819 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 331636002820 DNA topoisomerase I/SWI domain fusion protein; Validated; Region: PRK06319 331636002821 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 331636002822 active site 331636002823 interdomain interaction site; other site 331636002824 putative metal-binding site [ion binding]; other site 331636002825 nucleotide binding site [chemical binding]; other site 331636002826 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 331636002827 domain I; other site 331636002828 DNA binding groove [nucleotide binding] 331636002829 phosphate binding site [ion binding]; other site 331636002830 domain II; other site 331636002831 domain III; other site 331636002832 nucleotide binding site [chemical binding]; other site 331636002833 catalytic site [active] 331636002834 domain IV; other site 331636002835 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 331636002836 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 331636002837 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 331636002838 SWIB/MDM2 domain; Region: SWIB; pfam02201 331636002839 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 331636002840 FMN binding site [chemical binding]; other site 331636002841 active site 331636002842 catalytic residues [active] 331636002843 substrate binding site [chemical binding]; other site 331636002844 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 331636002845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 331636002846 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 331636002847 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 331636002848 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 331636002849 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 331636002850 hexamer interface [polypeptide binding]; other site 331636002851 Walker A motif; other site 331636002852 ATP binding site [chemical binding]; other site 331636002853 Walker B motif; other site 331636002854 putative folate metabolism protein, CADD family; Region: fol_rel_CADD; TIGR04305 331636002855 putative folate metabolism gamma-glutamate ligase; Region: intra_fol_E_lig; TIGR04132 331636002856 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 331636002857 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 331636002858 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 331636002859 folate binding site [chemical binding]; other site 331636002860 NADP+ binding site [chemical binding]; other site 331636002861 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 331636002862 catalytic center binding site [active] 331636002863 ATP binding site [chemical binding]; other site 331636002864 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 331636002865 dihydropteroate synthase; Region: DHPS; TIGR01496 331636002866 substrate binding pocket [chemical binding]; other site 331636002867 dimer interface [polypeptide binding]; other site 331636002868 inhibitor binding site; inhibition site 331636002869 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 331636002870 active site 331636002871 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 331636002872 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 331636002873 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 331636002874 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 331636002875 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 331636002876 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 331636002877 DNA binding residues [nucleotide binding] 331636002878 Uncharacterized protein family (UPF0242); Region: UPF0242; pfam06785 331636002879 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 331636002880 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 331636002881 AAA domain; Region: AAA_30; pfam13604 331636002882 Family description; Region: UvrD_C_2; pfam13538 331636002883 Protein of unknown function (DUF1347); Region: DUF1347; pfam07079 331636002884 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 331636002885 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331636002886 DNA binding site [nucleotide binding] 331636002887 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 331636002888 putative trimer interface [polypeptide binding]; other site 331636002889 putative CoA binding site [chemical binding]; other site 331636002890 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 331636002891 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 331636002892 substrate binding pocket [chemical binding]; other site 331636002893 chain length determination region; other site 331636002894 catalytic residues [active] 331636002895 aspartate-rich region 1; other site 331636002896 substrate-Mg2+ binding site; other site 331636002897 active site lid residues [active] 331636002898 Predicted alternative thymidylate synthase [Nucleotide transport and metabolism]; Region: THY1; COG1351 331636002899 Thymidylate synthase complementing protein; Region: Thy1; cl03630