-- dump date   	20140619_040938
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
517417000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
517417000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
517417000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517417000004	Walker A motif; other site
517417000005	ATP binding site [chemical binding]; other site
517417000006	Walker B motif; other site
517417000007	arginine finger; other site
517417000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
517417000009	DnaA box-binding interface [nucleotide binding]; other site
517417000010	DNA polymerase III subunit beta; Provisional; Region: PRK14941
517417000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
517417000012	putative DNA binding surface [nucleotide binding]; other site
517417000013	dimer interface [polypeptide binding]; other site
517417000014	beta-clamp/clamp loader binding surface; other site
517417000015	beta-clamp/translesion DNA polymerase binding surface; other site
517417000016	recombination protein F; Reviewed; Region: recF; PRK00064
517417000017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
517417000018	Walker A/P-loop; other site
517417000019	ATP binding site [chemical binding]; other site
517417000020	Q-loop/lid; other site
517417000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
517417000022	ABC transporter signature motif; other site
517417000023	Walker B; other site
517417000024	D-loop; other site
517417000025	H-loop/switch region; other site
517417000026	Protein of unknown function (DUF721); Region: DUF721; pfam05258
517417000027	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
517417000028	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
517417000029	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
517417000030	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like2_exo; cd05785
517417000031	DNA polymerase type-B family; Region: POLBc; smart00486
517417000032	active site
517417000033	catalytic site [active]
517417000034	substrate binding site [chemical binding]; other site
517417000035	DNA polymerase type-II B subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II_B; cd05538
517417000036	active site
517417000037	metal-binding site
517417000038	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
517417000039	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
517417000040	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
517417000041	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
517417000042	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
517417000043	Low molecular weight phosphatase family; Region: LMWPc; cd00115
517417000044	active site
517417000045	Cytochrome c; Region: Cytochrom_C; cl11414
517417000046	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
517417000047	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
517417000048	Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342
517417000049	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
517417000050	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
517417000051	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
517417000052	Protein export membrane protein; Region: SecD_SecF; pfam02355
517417000053	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
517417000054	SurA N-terminal domain; Region: SurA_N; pfam09312
517417000055	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
517417000056	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
517417000057	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
517417000058	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517417000059	ATP binding site [chemical binding]; other site
517417000060	Mg2+ binding site [ion binding]; other site
517417000061	G-X-G motif; other site
517417000062	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
517417000063	anchoring element; other site
517417000064	dimer interface [polypeptide binding]; other site
517417000065	ATP binding site [chemical binding]; other site
517417000066	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
517417000067	active site
517417000068	putative metal-binding site [ion binding]; other site
517417000069	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
517417000070	hypothetical protein; Reviewed; Region: PRK12497
517417000071	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
517417000072	RNA/DNA hybrid binding site [nucleotide binding]; other site
517417000073	active site
517417000074	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
517417000075	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
517417000076	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
517417000077	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
517417000078	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
517417000079	trimer interface [polypeptide binding]; other site
517417000080	active site
517417000081	substrate binding site [chemical binding]; other site
517417000082	CoA binding site [chemical binding]; other site
517417000083	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
517417000084	C-terminal peptidase (prc); Region: prc; TIGR00225
517417000085	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
517417000086	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
517417000087	Catalytic dyad [active]
517417000088	Protein of unknown function (DUF2499); Region: DUF2499; pfam10693
517417000089	Protein of unknown function (DUF3593); Region: DUF3593; pfam12159
517417000090	geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023
517417000091	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
517417000092	glycyl-tRNA synthetase; Provisional; Region: PRK04173
517417000093	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
517417000094	motif 1; other site
517417000095	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
517417000096	active site
517417000097	motif 2; other site
517417000098	motif 3; other site
517417000099	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
517417000100	anticodon binding site; other site
517417000101	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
517417000102	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
517417000103	active site residue [active]
517417000104	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
517417000105	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
517417000106	catalytic triad [active]
517417000107	DsrC like protein; Region: DsrC; pfam04358
517417000108	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
517417000109	sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064
517417000110	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
517417000111	sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066
517417000112	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
517417000113	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
517417000114	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
517417000115	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
517417000116	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
517417000117	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
517417000118	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
517417000119	Cysteine-rich domain; Region: CCG; pfam02754
517417000120	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
517417000121	4Fe-4S binding domain; Region: Fer4; cl02805
517417000122	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
517417000123	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
517417000124	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
517417000125	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
517417000126	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
517417000127	active site
517417000128	SAM binding site [chemical binding]; other site
517417000129	homodimer interface [polypeptide binding]; other site
517417000130	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
517417000131	active site
517417000132	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
517417000133	active site
517417000134	PAS fold; Region: PAS_4; pfam08448
517417000135	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517417000136	putative active site [active]
517417000137	heme pocket [chemical binding]; other site
517417000138	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617
517417000139	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
517417000140	dimer interface [polypeptide binding]; other site
517417000141	catalytic triad [active]
517417000142	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
517417000143	gamma subunit interface [polypeptide binding]; other site
517417000144	epsilon subunit interface [polypeptide binding]; other site
517417000145	LBP interface [polypeptide binding]; other site
517417000146	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
517417000147	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
517417000148	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
517417000149	alpha subunit interaction interface [polypeptide binding]; other site
517417000150	Walker A motif; other site
517417000151	ATP binding site [chemical binding]; other site
517417000152	Walker B motif; other site
517417000153	inhibitor binding site; inhibition site
517417000154	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
517417000155	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
517417000156	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
517417000157	catalytic residues [active]
517417000158	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
517417000159	active site
517417000160	substrate-binding site [chemical binding]; other site
517417000161	metal-binding site [ion binding]
517417000162	GTP binding site [chemical binding]; other site
517417000163	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
517417000164	Dodecin; Region: Dodecin; pfam07311
517417000165	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
517417000166	H+ Antiporter protein; Region: 2A0121; TIGR00900
517417000167	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
517417000168	putative substrate translocation pore; other site
517417000169	methionine sulfoxide reductase B; Provisional; Region: PRK00222
517417000170	SelR domain; Region: SelR; pfam01641
517417000171	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
517417000172	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
517417000173	putative substrate translocation pore; other site
517417000174	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
517417000175	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
517417000176	HlyD family secretion protein; Region: HlyD_3; pfam13437
517417000177	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
517417000178	Ligand Binding Site [chemical binding]; other site
517417000179	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
517417000180	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
517417000181	GAF domain; Region: GAF; pfam01590
517417000182	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
517417000183	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517417000184	Walker A motif; other site
517417000185	ATP binding site [chemical binding]; other site
517417000186	Walker B motif; other site
517417000187	arginine finger; other site
517417000188	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
517417000189	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
517417000190	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
517417000191	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
517417000192	P loop; other site
517417000193	Nucleotide binding site [chemical binding]; other site
517417000194	DTAP/Switch II; other site
517417000195	Switch I; other site
517417000196	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
517417000197	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
517417000198	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
517417000199	Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139
517417000200	putative FMN binding site [chemical binding]; other site
517417000201	Ion channel; Region: Ion_trans_2; pfam07885
517417000202	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
517417000203	TrkA-N domain; Region: TrkA_N; pfam02254
517417000204	TrkA-C domain; Region: TrkA_C; pfam02080
517417000205	peptide chain release factor 1; Validated; Region: prfA; PRK00591
517417000206	This domain is found in peptide chain release factors; Region: PCRF; smart00937
517417000207	RF-1 domain; Region: RF-1; pfam00472
517417000208	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
517417000209	RIP metalloprotease RseP; Region: TIGR00054
517417000210	active site
517417000211	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
517417000212	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
517417000213	protein binding site [polypeptide binding]; other site
517417000214	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
517417000215	putative substrate binding region [chemical binding]; other site
517417000216	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
517417000217	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
517417000218	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
517417000219	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
517417000220	acylphosphatase; Provisional; Region: PRK14445
517417000221	FtsH Extracellular; Region: FtsH_ext; pfam06480
517417000222	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
517417000223	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517417000224	Walker B motif; other site
517417000225	arginine finger; other site
517417000226	Peptidase family M41; Region: Peptidase_M41; pfam01434
517417000227	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
517417000228	active site
517417000229	dimer interface [polypeptide binding]; other site
517417000230	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
517417000231	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
517417000232	glutaminase active site [active]
517417000233	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
517417000234	dimer interface [polypeptide binding]; other site
517417000235	active site
517417000236	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
517417000237	dimer interface [polypeptide binding]; other site
517417000238	active site
517417000239	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
517417000240	CRISPR/Cas system-associated protein Csx15; Region: Csx15_I-U; cd09766
517417000241	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680
517417000242	CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622
517417000243	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
517417000244	CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438
517417000245	CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437
517417000246	CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437
517417000247	CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437
517417000248	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817
517417000249	CRISPR associated protein Cas6; Region: Cas_Cas6; pfam01881
517417000250	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
517417000251	TIGR01777 family protein; Region: yfcH
517417000252	putative NAD(P) binding site [chemical binding]; other site
517417000253	putative active site [active]
517417000254	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
517417000255	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
517417000256	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
517417000257	Nitrogen regulatory protein P-II; Region: P-II; smart00938
517417000258	TPR repeat; Region: TPR_11; pfam13414
517417000259	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517417000260	binding surface
517417000261	TPR motif; other site
517417000262	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
517417000263	binding surface
517417000264	TPR motif; other site
517417000265	ScpA/B protein; Region: ScpA_ScpB; cl00598
517417000266	Uncharacterized conserved protein [Function unknown]; Region: COG4198
517417000267	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
517417000268	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
517417000269	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
517417000270	Glycoprotease family; Region: Peptidase_M22; pfam00814
517417000271	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
517417000272	DNA gyrase subunit A; Validated; Region: PRK05560
517417000273	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
517417000274	CAP-like domain; other site
517417000275	active site
517417000276	primary dimer interface [polypeptide binding]; other site
517417000277	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
517417000278	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
517417000279	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
517417000280	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
517417000281	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
517417000282	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
517417000283	CTP synthetase; Validated; Region: pyrG; PRK05380
517417000284	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
517417000285	Catalytic site [active]
517417000286	active site
517417000287	UTP binding site [chemical binding]; other site
517417000288	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
517417000289	active site
517417000290	putative oxyanion hole; other site
517417000291	catalytic triad [active]
517417000292	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
517417000293	non-specific DNA binding site [nucleotide binding]; other site
517417000294	salt bridge; other site
517417000295	sequence-specific DNA binding site [nucleotide binding]; other site
517417000296	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
517417000297	Catalytic site [active]
517417000298	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
517417000299	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
517417000300	Cysteine-rich domain; Region: CCG; pfam02754
517417000301	Cysteine-rich domain; Region: CCG; pfam02754
517417000302	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
517417000303	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
517417000304	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
517417000305	active site
517417000306	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
517417000307	Ligand binding site [chemical binding]; other site
517417000308	Electron transfer flavoprotein domain; Region: ETF; pfam01012
517417000309	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
517417000310	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
517417000311	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
517417000312	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
517417000313	active site
517417000314	Fic family protein [Function unknown]; Region: COG3177
517417000315	Fic/DOC family; Region: Fic; pfam02661
517417000316	Domain of Unknown Function (DUF3856); Region: DUF3856; pfam12968
517417000317	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
517417000318	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
517417000319	putative active site [active]
517417000320	Exonuclease III [DNA replication, recombination, and repair]; Region: XthA; COG0708
517417000321	putative catalytic site [active]
517417000322	putative metal binding site [ion binding]; other site
517417000323	putative phosphate binding site [ion binding]; other site
517417000324	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
517417000325	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
517417000326	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
517417000327	dimer interface [polypeptide binding]; other site
517417000328	ssDNA binding site [nucleotide binding]; other site
517417000329	tetramer (dimer of dimers) interface [polypeptide binding]; other site
517417000330	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
517417000331	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
517417000332	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
517417000333	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
517417000334	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
517417000335	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
517417000336	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
517417000337	dimer interface [polypeptide binding]; other site
517417000338	motif 1; other site
517417000339	active site
517417000340	motif 2; other site
517417000341	motif 3; other site
517417000342	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
517417000343	23S rRNA binding site [nucleotide binding]; other site
517417000344	L21 binding site [polypeptide binding]; other site
517417000345	L13 binding site [polypeptide binding]; other site
517417000346	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
517417000347	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
517417000348	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
517417000349	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
517417000350	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
517417000351	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
517417000352	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
517417000353	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
517417000354	active site
517417000355	dimer interface [polypeptide binding]; other site
517417000356	motif 1; other site
517417000357	motif 2; other site
517417000358	motif 3; other site
517417000359	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
517417000360	anticodon binding site; other site
517417000361	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
517417000362	chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014
517417000363	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
517417000364	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
517417000365	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
517417000366	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
517417000367	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
517417000368	tetramer interface [polypeptide binding]; other site
517417000369	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517417000370	catalytic residue [active]
517417000371	response regulator; Provisional; Region: PRK13435
517417000372	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
517417000373	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
517417000374	dimerization interface [polypeptide binding]; other site
517417000375	active site
517417000376	metal binding site [ion binding]; metal-binding site
517417000377	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
517417000378	dsRNA binding site [nucleotide binding]; other site
517417000379	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
517417000380	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
517417000381	dimer interface [polypeptide binding]; other site
517417000382	active site
517417000383	acyl carrier protein; Provisional; Region: acpP; PRK00982
517417000384	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
517417000385	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
517417000386	NAD(P) binding site [chemical binding]; other site
517417000387	homotetramer interface [polypeptide binding]; other site
517417000388	homodimer interface [polypeptide binding]; other site
517417000389	active site
517417000390	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
517417000391	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
517417000392	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
517417000393	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
517417000394	dimer interface [polypeptide binding]; other site
517417000395	active site
517417000396	CoA binding pocket [chemical binding]; other site
517417000397	putative phosphate acyltransferase; Provisional; Region: PRK05331
517417000398	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
517417000399	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
517417000400	Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449
517417000401	GIY-YIG motif/motif A; other site
517417000402	putative active site [active]
517417000403	putative metal binding site [ion binding]; other site
517417000404	META domain; Region: META; pfam03724
517417000405	2-isopropylmalate synthase; Validated; Region: PRK03739
517417000406	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
517417000407	active site
517417000408	catalytic residues [active]
517417000409	metal binding site [ion binding]; metal-binding site
517417000410	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
517417000411	Metal binding protein ZntC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018
517417000412	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
517417000413	putative metal binding residues [ion binding]; other site
517417000414	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
517417000415	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
517417000416	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
517417000417	ABC 3 transport family; Region: ABC-3; pfam00950
517417000418	dimer interface [polypeptide binding]; other site
517417000419	putative PBP binding regions; other site
517417000420	ABC-ATPase subunit  interface; other site
517417000421	camphor resistance protein CrcB; Provisional; Region: PRK14202
517417000422	PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993
517417000423	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
517417000424	active site
517417000425	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
517417000426	non-specific DNA binding site [nucleotide binding]; other site
517417000427	salt bridge; other site
517417000428	sequence-specific DNA binding site [nucleotide binding]; other site
517417000429	HipA N-terminal domain; Region: Couple_hipA; pfam13657
517417000430	HipA-like N-terminal domain; Region: HipA_N; pfam07805
517417000431	HipA-like C-terminal domain; Region: HipA_C; pfam07804
517417000432	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
517417000433	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
517417000434	inhibitor-cofactor binding pocket; inhibition site
517417000435	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517417000436	catalytic residue [active]
517417000437	Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381
517417000438	Recombination protein O N terminal; Region: RecO_N; pfam11967
517417000439	Recombination protein O C terminal; Region: RecO_C; pfam02565
517417000440	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
517417000441	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
517417000442	putative amphipathic alpha helix; other site
517417000443	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
517417000444	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
517417000445	GatB domain; Region: GatB_Yqey; smart00845
517417000446	Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609
517417000447	GTPase CgtA; Reviewed; Region: obgE; PRK12299
517417000448	GTP1/OBG; Region: GTP1_OBG; pfam01018
517417000449	Obg GTPase; Region: Obg; cd01898
517417000450	G1 box; other site
517417000451	GTP/Mg2+ binding site [chemical binding]; other site
517417000452	Switch I region; other site
517417000453	G2 box; other site
517417000454	G3 box; other site
517417000455	Switch II region; other site
517417000456	G4 box; other site
517417000457	G5 box; other site
517417000458	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
517417000459	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
517417000460	Coenzyme A binding pocket [chemical binding]; other site
517417000461	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
517417000462	dimerization domain swap beta strand [polypeptide binding]; other site
517417000463	regulatory protein interface [polypeptide binding]; other site
517417000464	active site
517417000465	regulatory phosphorylation site [posttranslational modification]; other site
517417000466	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
517417000467	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
517417000468	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
517417000469	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
517417000470	Probable Catalytic site; other site
517417000471	metal-binding site
517417000472	Methyltransferase domain; Region: Methyltransf_23; pfam13489
517417000473	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
517417000474	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
517417000475	putative homodimer interface [polypeptide binding]; other site
517417000476	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
517417000477	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
517417000478	Predicted membrane protein [Function unknown]; Region: COG4485
517417000479	Domain of unknown function DUF302; Region: DUF302; pfam03625
517417000480	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
517417000481	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
517417000482	oligomer interface [polypeptide binding]; other site
517417000483	metal binding site [ion binding]; metal-binding site
517417000484	metal binding site [ion binding]; metal-binding site
517417000485	Cl binding site [ion binding]; other site
517417000486	aspartate ring; other site
517417000487	basic sphincter; other site
517417000488	putative hydrophobic gate; other site
517417000489	periplasmic entrance; other site
517417000490	Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350
517417000491	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
517417000492	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
517417000493	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
517417000494	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
517417000495	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
517417000496	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
517417000497	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
517417000498	S17 interaction site [polypeptide binding]; other site
517417000499	S8 interaction site; other site
517417000500	16S rRNA interaction site [nucleotide binding]; other site
517417000501	streptomycin interaction site [chemical binding]; other site
517417000502	23S rRNA interaction site [nucleotide binding]; other site
517417000503	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
517417000504	30S ribosomal protein S7; Validated; Region: PRK05302
517417000505	elongation factor G; Reviewed; Region: PRK00007
517417000506	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
517417000507	G1 box; other site
517417000508	putative GEF interaction site [polypeptide binding]; other site
517417000509	GTP/Mg2+ binding site [chemical binding]; other site
517417000510	Switch I region; other site
517417000511	G2 box; other site
517417000512	G3 box; other site
517417000513	Switch II region; other site
517417000514	G4 box; other site
517417000515	G5 box; other site
517417000516	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
517417000517	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
517417000518	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
517417000519	elongation factor Tu; Reviewed; Region: PRK00049
517417000520	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
517417000521	G1 box; other site
517417000522	GEF interaction site [polypeptide binding]; other site
517417000523	GTP/Mg2+ binding site [chemical binding]; other site
517417000524	Switch I region; other site
517417000525	G2 box; other site
517417000526	G3 box; other site
517417000527	Switch II region; other site
517417000528	G4 box; other site
517417000529	G5 box; other site
517417000530	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
517417000531	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
517417000532	Antibiotic Binding Site [chemical binding]; other site
517417000533	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
517417000534	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
517417000535	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
517417000536	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
517417000537	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
517417000538	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
517417000539	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
517417000540	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
517417000541	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
517417000542	putative translocon binding site; other site
517417000543	protein-rRNA interface [nucleotide binding]; other site
517417000544	ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009
517417000545	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
517417000546	G-X-X-G motif; other site
517417000547	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
517417000548	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
517417000549	23S rRNA interface [nucleotide binding]; other site
517417000550	5S rRNA interface [nucleotide binding]; other site
517417000551	putative antibiotic binding site [chemical binding]; other site
517417000552	L25 interface [polypeptide binding]; other site
517417000553	L27 interface [polypeptide binding]; other site
517417000554	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
517417000555	putative translocon interaction site; other site
517417000556	23S rRNA interface [nucleotide binding]; other site
517417000557	signal recognition particle (SRP54) interaction site; other site
517417000558	L23 interface [polypeptide binding]; other site
517417000559	trigger factor interaction site; other site
517417000560	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
517417000561	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
517417000562	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
517417000563	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
517417000564	RNA binding site [nucleotide binding]; other site
517417000565	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
517417000566	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
517417000567	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
517417000568	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
517417000569	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
517417000570	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
517417000571	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
517417000572	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
517417000573	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
517417000574	5S rRNA interface [nucleotide binding]; other site
517417000575	23S rRNA interface [nucleotide binding]; other site
517417000576	L5 interface [polypeptide binding]; other site
517417000577	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
517417000578	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
517417000579	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
517417000580	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
517417000581	23S rRNA binding site [nucleotide binding]; other site
517417000582	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
517417000583	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
517417000584	SecY translocase; Region: SecY; pfam00344
517417000585	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
517417000586	active site
517417000587	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
517417000588	rRNA binding site [nucleotide binding]; other site
517417000589	predicted 30S ribosome binding site; other site
517417000590	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
517417000591	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
517417000592	30S ribosomal protein S13; Region: bact_S13; TIGR03631
517417000593	30S ribosomal protein S11; Validated; Region: PRK05309
517417000594	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
517417000595	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
517417000596	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
517417000597	RNA binding surface [nucleotide binding]; other site
517417000598	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
517417000599	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
517417000600	alphaNTD homodimer interface [polypeptide binding]; other site
517417000601	alphaNTD - beta interaction site [polypeptide binding]; other site
517417000602	alphaNTD - beta' interaction site [polypeptide binding]; other site
517417000603	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
517417000604	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
517417000605	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
517417000606	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
517417000607	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
517417000608	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
517417000609	Substrate binding site; other site
517417000610	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
517417000611	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
517417000612	active site
517417000613	HIGH motif; other site
517417000614	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
517417000615	KMSKS motif; other site
517417000616	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
517417000617	tRNA binding surface [nucleotide binding]; other site
517417000618	anticodon binding site; other site
517417000619	Domain of unknown function DUF302; Region: DUF302; cl01364
517417000620	Mechanosensitive ion channel; Region: MS_channel; pfam00924
517417000621	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
517417000622	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
517417000623	substrate binding pocket [chemical binding]; other site
517417000624	Ion channel; Region: Ion_trans_2; pfam07885
517417000625	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
517417000626	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
517417000627	membrane-bound complex binding site; other site
517417000628	hinge residues; other site
517417000629	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
517417000630	iron-sulfur cluster [ion binding]; other site
517417000631	[2Fe-2S] cluster binding site [ion binding]; other site
517417000632	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
517417000633	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
517417000634	active site
517417000635	FMN binding site [chemical binding]; other site
517417000636	substrate binding site [chemical binding]; other site
517417000637	3Fe-4S cluster binding site [ion binding]; other site
517417000638	von Willebrand factor type A domain; Region: VWA_2; pfam13519
517417000639	metal ion-dependent adhesion site (MIDAS); other site
517417000640	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
517417000641	AAA domain; Region: AAA_33; pfam13671
517417000642	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
517417000643	G1 box; other site
517417000644	GTP/Mg2+ binding site [chemical binding]; other site
517417000645	Switch I region; other site
517417000646	G2 box; other site
517417000647	G3 box; other site
517417000648	Switch II region; other site
517417000649	G4 box; other site
517417000650	G5 box; other site
517417000651	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
517417000652	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
517417000653	GDP-binding site [chemical binding]; other site
517417000654	ACT binding site; other site
517417000655	IMP binding site; other site
517417000656	Domain of unknown function DUF77; Region: DUF77; pfam01910
517417000657	Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979
517417000658	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
517417000659	light-independent protochlorophyllide reductase, B subunit; Region: DPOR_BchB; TIGR01278
517417000660	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
517417000661	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
517417000662	protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185
517417000663	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
517417000664	P-loop; other site
517417000665	Mechanosensitive ion channel; Region: MS_channel; pfam00924
517417000666	Radical SAM superfamily; Region: Radical_SAM; pfam04055
517417000667	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517417000668	FeS/SAM binding site; other site
517417000669	bacteriochlorophyll 4-vinyl reductase; Region: BchJ; TIGR02019
517417000670	Bacterial Ig-like domain; Region: Big_5; pfam13205
517417000671	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
517417000672	glycogen synthase; Provisional; Region: PRK14098
517417000673	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
517417000674	ADP-binding pocket [chemical binding]; other site
517417000675	homodimer interface [polypeptide binding]; other site
517417000676	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
517417000677	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
517417000678	active site
517417000679	motif I; other site
517417000680	motif II; other site
517417000681	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
517417000682	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517417000683	FeS/SAM binding site; other site
517417000684	Protein of unknown function (DUF2723); Region: DUF2723; pfam11028
517417000685	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
517417000686	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
517417000687	active site
517417000688	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
517417000689	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
517417000690	nucleotide binding site [chemical binding]; other site
517417000691	DNA utilization protein GntX; Provisional; Region: PRK11595
517417000692	C4-type zinc-finger of DNA polymerase delta; Region: zf-C4pol; pfam14260
517417000693	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
517417000694	active site
517417000695	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
517417000696	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
517417000697	Domain of unknown function DUF20; Region: UPF0118; pfam01594
517417000698	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
517417000699	active site
517417000700	multimer interface [polypeptide binding]; other site
517417000701	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
517417000702	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
517417000703	catalytic triad [active]
517417000704	Domain of unknown function DUF21; Region: DUF21; pfam01595
517417000705	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
517417000706	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
517417000707	Transporter associated domain; Region: CorC_HlyC; smart01091
517417000708	Helix-turn-helix domain; Region: HTH_25; pfam13413
517417000709	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
517417000710	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
517417000711	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
517417000712	catalytic residue [active]
517417000713	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
517417000714	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
517417000715	trimerization site [polypeptide binding]; other site
517417000716	active site
517417000717	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
517417000718	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14340
517417000719	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
517417000720	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517417000721	FeS/SAM binding site; other site
517417000722	TRAM domain; Region: TRAM; pfam01938
517417000723	bacteriochlorophyll c synthase; Provisional; Region: PRK12392
517417000724	UbiA prenyltransferase family; Region: UbiA; pfam01040
517417000725	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
517417000726	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
517417000727	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
517417000728	putative active site [active]
517417000729	putative metal binding site [ion binding]; other site
517417000730	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
517417000731	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
517417000732	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
517417000733	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
517417000734	DXD motif; other site
517417000735	FOG: WD40 repeat [General function prediction only]; Region: COG2319
517417000736	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
517417000737	structural tetrad; other site
517417000738	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
517417000739	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
517417000740	hypothetical protein; Provisional; Region: PRK09256
517417000741	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
517417000742	putative peptidase; Provisional; Region: PRK11649
517417000743	Peptidase family M23; Region: Peptidase_M23; pfam01551
517417000744	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
517417000745	nucleotide binding site/active site [active]
517417000746	HIT family signature motif; other site
517417000747	catalytic residue [active]
517417000748	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
517417000749	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
517417000750	putative dimer interface [polypeptide binding]; other site
517417000751	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
517417000752	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517417000753	S-adenosylmethionine binding site [chemical binding]; other site
517417000754	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
517417000755	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
517417000756	active site
517417000757	catalytic tetrad [active]
517417000758	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026
517417000759	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
517417000760	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517417000761	FeS/SAM binding site; other site
517417000762	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
517417000763	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517417000764	S-adenosylmethionine binding site [chemical binding]; other site
517417000765	Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109
517417000766	magnesium chelatase subunit H; Provisional; Region: PRK12493
517417000767	Domain of unknown function (DUF3479); Region: DUF3479; pfam11965
517417000768	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
517417000769	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
517417000770	magnesium chelatase, H subunit; Region: BchH; TIGR02025
517417000771	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
517417000772	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
517417000773	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
517417000774	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
517417000775	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
517417000776	N-terminal plug; other site
517417000777	ligand-binding site [chemical binding]; other site
517417000778	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
517417000779	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
517417000780	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
517417000781	catalytic residue [active]
517417000782	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
517417000783	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517417000784	NAD(P) binding site [chemical binding]; other site
517417000785	active site
517417000786	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
517417000787	DNA polymerase III, delta subunit; Region: holA; TIGR01128
517417000788	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
517417000789	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
517417000790	dimer interface [polypeptide binding]; other site
517417000791	ssDNA binding site [nucleotide binding]; other site
517417000792	tetramer (dimer of dimers) interface [polypeptide binding]; other site
517417000793	2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
517417000794	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
517417000795	FAD binding pocket [chemical binding]; other site
517417000796	FAD binding motif [chemical binding]; other site
517417000797	phosphate binding motif [ion binding]; other site
517417000798	beta-alpha-beta structure motif; other site
517417000799	NAD binding pocket [chemical binding]; other site
517417000800	Iron coordination center [ion binding]; other site
517417000801	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
517417000802	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
517417000803	P loop; other site
517417000804	Nucleotide binding site [chemical binding]; other site
517417000805	DTAP/Switch II; other site
517417000806	Switch I; other site
517417000807	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
517417000808	Chlorosome envelope protein C; Region: Chlorosome_CsmC; pfam11098
517417000809	Bacteriochlorophyll C binding protein; Region: Bac_chlorC; pfam02043
517417000810	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
517417000811	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
517417000812	P loop; other site
517417000813	Nucleotide binding site [chemical binding]; other site
517417000814	DTAP/Switch II; other site
517417000815	Switch I; other site
517417000816	This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins.  sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298
517417000817	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
517417000818	catalytic center binding site [active]
517417000819	ATP binding site [chemical binding]; other site
517417000820	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
517417000821	active site
517417000822	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
517417000823	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
517417000824	dimerization interface [polypeptide binding]; other site
517417000825	active site
517417000826	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
517417000827	trigger factor; Region: tig; TIGR00115
517417000828	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
517417000829	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
517417000830	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
517417000831	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
517417000832	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
517417000833	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
517417000834	putative NADP binding site [chemical binding]; other site
517417000835	putative substrate binding site [chemical binding]; other site
517417000836	active site
517417000837	recombinase A; Provisional; Region: recA; PRK09354
517417000838	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
517417000839	hexamer interface [polypeptide binding]; other site
517417000840	Walker A motif; other site
517417000841	ATP binding site [chemical binding]; other site
517417000842	Walker B motif; other site
517417000843	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
517417000844	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
517417000845	FMN binding site [chemical binding]; other site
517417000846	active site
517417000847	catalytic residues [active]
517417000848	substrate binding site [chemical binding]; other site
517417000849	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
517417000850	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
517417000851	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
517417000852	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
517417000853	alanine racemase; Reviewed; Region: alr; PRK00053
517417000854	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
517417000855	active site
517417000856	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
517417000857	dimer interface [polypeptide binding]; other site
517417000858	substrate binding site [chemical binding]; other site
517417000859	catalytic residues [active]
517417000860	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
517417000861	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
517417000862	dimer interface [polypeptide binding]; other site
517417000863	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517417000864	catalytic residue [active]
517417000865	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
517417000866	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
517417000867	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
517417000868	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
517417000869	hinge; other site
517417000870	active site
517417000871	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
517417000872	dimerization interface [polypeptide binding]; other site
517417000873	active site
517417000874	Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659
517417000875	MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937
517417000876	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
517417000877	Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752
517417000878	YtxH-like protein; Region: YtxH; pfam12732
517417000879	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
517417000880	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
517417000881	Zn2+ binding site [ion binding]; other site
517417000882	Mg2+ binding site [ion binding]; other site
517417000883	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
517417000884	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
517417000885	Walker A/P-loop; other site
517417000886	ATP binding site [chemical binding]; other site
517417000887	Q-loop/lid; other site
517417000888	ABC transporter signature motif; other site
517417000889	Walker B; other site
517417000890	D-loop; other site
517417000891	H-loop/switch region; other site
517417000892	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
517417000893	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
517417000894	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
517417000895	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
517417000896	trimer interface [polypeptide binding]; other site
517417000897	putative metal binding site [ion binding]; other site
517417000898	Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232
517417000899	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
517417000900	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
517417000901	Mechanosensitive ion channel; Region: MS_channel; pfam00924
517417000902	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
517417000903	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
517417000904	uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334
517417000905	Na2 binding site [ion binding]; other site
517417000906	putative substrate binding site 1 [chemical binding]; other site
517417000907	Na binding site 1 [ion binding]; other site
517417000908	putative substrate binding site 2 [chemical binding]; other site
517417000909	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
517417000910	Short C-terminal domain; Region: SHOCT; pfam09851
517417000911	Tim44-like domain; Region: Tim44; cl09208
517417000912	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
517417000913	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517417000914	NAD(P) binding site [chemical binding]; other site
517417000915	active site
517417000916	SapC; Region: SapC; pfam07277
517417000917	YadA-like C-terminal region; Region: YadA; pfam03895
517417000918	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
517417000919	Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941
517417000920	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
517417000921	cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345
517417000922	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
517417000923	FAD binding pocket [chemical binding]; other site
517417000924	FAD binding motif [chemical binding]; other site
517417000925	phosphate binding motif [ion binding]; other site
517417000926	beta-alpha-beta structure motif; other site
517417000927	NAD binding pocket [chemical binding]; other site
517417000928	Iron coordination center [ion binding]; other site
517417000929	sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910
517417000930	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
517417000931	Peptidase family U32; Region: Peptidase_U32; pfam01136
517417000932	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
517417000933	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
517417000934	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
517417000935	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
517417000936	Uncharacterized conserved protein [Function unknown]; Region: COG2128
517417000937	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
517417000938	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
517417000939	Ligand Binding Site [chemical binding]; other site
517417000940	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
517417000941	Ligand Binding Site [chemical binding]; other site
517417000942	AAA domain; Region: AAA_32; pfam13654
517417000943	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
517417000944	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
517417000945	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
517417000946	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
517417000947	ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087
517417000948	NAD(P) binding site [chemical binding]; other site
517417000949	catalytic residues [active]
517417000950	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
517417000951	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
517417000952	nucleophile elbow; other site
517417000953	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
517417000954	putative deacylase active site [active]
517417000955	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
517417000956	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
517417000957	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_6; cd06256
517417000958	putative active site [active]
517417000959	Zn binding site [ion binding]; other site
517417000960	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
517417000961	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
517417000962	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
517417000963	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
517417000964	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
517417000965	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
517417000966	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
517417000967	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
517417000968	Transposase IS200 like; Region: Y1_Tnp; pfam01797
517417000969	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
517417000970	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
517417000971	putative active site [active]
517417000972	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
517417000973	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
517417000974	TPP-binding site [chemical binding]; other site
517417000975	dimer interface [polypeptide binding]; other site
517417000976	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
517417000977	PYR/PP interface [polypeptide binding]; other site
517417000978	dimer interface [polypeptide binding]; other site
517417000979	TPP binding site [chemical binding]; other site
517417000980	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
517417000981	Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042
517417000982	Uncharacterized conserved protein [Function unknown]; Region: COG2968
517417000983	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
517417000984	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
517417000985	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
517417000986	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
517417000987	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
517417000988	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
517417000989	putative hydrophobic ligand binding site [chemical binding]; other site
517417000990	Restriction endonuclease; Region: Mrr_cat; pfam04471
517417000991	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
517417000992	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
517417000993	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
517417000994	substrate binding pocket [chemical binding]; other site
517417000995	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
517417000996	B12 binding site [chemical binding]; other site
517417000997	cobalt ligand [ion binding]; other site
517417000998	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
517417000999	Predicted esterase [General function prediction only]; Region: COG0400
517417001000	putative hydrolase; Provisional; Region: PRK11460
517417001001	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
517417001002	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
517417001003	Ligand Binding Site [chemical binding]; other site
517417001004	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
517417001005	MgtE intracellular N domain; Region: MgtE_N; pfam03448
517417001006	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
517417001007	Divalent cation transporter; Region: MgtE; pfam01769
517417001008	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
517417001009	active site
517417001010	DNA binding site [nucleotide binding]
517417001011	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
517417001012	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
517417001013	P-loop; other site
517417001014	Magnesium ion binding site [ion binding]; other site
517417001015	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
517417001016	Magnesium ion binding site [ion binding]; other site
517417001017	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
517417001018	ParB-like nuclease domain; Region: ParB; smart00470
517417001019	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
517417001020	KorB domain; Region: KorB; pfam08535
517417001021	dihydrodipicolinate reductase; Provisional; Region: PRK00048
517417001022	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
517417001023	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
517417001024	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
517417001025	O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923
517417001026	acyl-activating enzyme (AAE) consensus motif; other site
517417001027	putative AMP binding site [chemical binding]; other site
517417001028	putative active site [active]
517417001029	putative CoA binding site [chemical binding]; other site
517417001030	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
517417001031	o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927
517417001032	active site
517417001033	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
517417001034	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
517417001035	substrate binding site [chemical binding]; other site
517417001036	oxyanion hole (OAH) forming residues; other site
517417001037	trimer interface [polypeptide binding]; other site
517417001038	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
517417001039	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
517417001040	DinB family; Region: DinB; cl17821
517417001041	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
517417001042	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517417001043	Walker A motif; other site
517417001044	ATP binding site [chemical binding]; other site
517417001045	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
517417001046	AAA domain; Region: AAA_12; pfam13087
517417001047	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
517417001048	putative active site [active]
517417001049	N-acetyltransferase; Region: Acetyltransf_2; cl00949
517417001050	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
517417001051	active site residue [active]
517417001052	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
517417001053	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
517417001054	dimer interface [polypeptide binding]; other site
517417001055	tetramer interface [polypeptide binding]; other site
517417001056	PYR/PP interface [polypeptide binding]; other site
517417001057	TPP binding site [chemical binding]; other site
517417001058	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
517417001059	TPP-binding site; other site
517417001060	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
517417001061	isochorismate synthases; Region: isochor_syn; TIGR00543
517417001062	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517417001063	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517417001064	binding surface
517417001065	TPR motif; other site
517417001066	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517417001067	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517417001068	binding surface
517417001069	TPR motif; other site
517417001070	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
517417001071	Chloroflexus aurantiacus (Ca) citrate synthase (CS)_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). This group is...; Region: CaCS_like; cd06116
517417001072	dimer interface [polypeptide binding]; other site
517417001073	Citrate synthase; Region: Citrate_synt; pfam00285
517417001074	active site
517417001075	citrylCoA binding site [chemical binding]; other site
517417001076	oxalacetate/citrate binding site [chemical binding]; other site
517417001077	coenzyme A binding site [chemical binding]; other site
517417001078	catalytic triad [active]
517417001079	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
517417001080	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
517417001081	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
517417001082	putative active site [active]
517417001083	dimerization interface [polypeptide binding]; other site
517417001084	putative tRNAtyr binding site [nucleotide binding]; other site
517417001085	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
517417001086	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
517417001087	Ligand binding site; other site
517417001088	oligomer interface; other site
517417001089	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
517417001090	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
517417001091	generic binding surface II; other site
517417001092	generic binding surface I; other site
517417001093	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
517417001094	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
517417001095	Sporulation related domain; Region: SPOR; pfam05036
517417001096	Chlide_reductase_Y : Y subunit of chlorophyllide (chlide) reductase (BchY).  Chlide reductase participates in photosynthetic pigment synthesis playing a role in the conversion of chlorophylls(Chl) into bacteriochlorophylls (BChl). Chlide reductase...; Region: Chlide_reductase_Y; cd01980
517417001097	chlorophyllide reductase subunit Y; Region: BchY; TIGR02015
517417001098	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
517417001099	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
517417001100	oligomeric interface; other site
517417001101	putative active site [active]
517417001102	homodimer interface [polypeptide binding]; other site
517417001103	DGQHR domain; Region: DGQHR; TIGR03187
517417001104	DNA phosphorothioation-associated DGQHR protein 1; Region: DGQHR_dnd_1; TIGR04172
517417001105	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
517417001106	ribosome recycling factor; Reviewed; Region: frr; PRK00083
517417001107	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
517417001108	hinge region; other site
517417001109	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
517417001110	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
517417001111	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
517417001112	ssDNA binding site; other site
517417001113	generic binding surface II; other site
517417001114	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
517417001115	ATP binding site [chemical binding]; other site
517417001116	putative Mg++ binding site [ion binding]; other site
517417001117	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
517417001118	nucleotide binding region [chemical binding]; other site
517417001119	ATP-binding site [chemical binding]; other site
517417001120	GTPase RsgA; Reviewed; Region: PRK00098
517417001121	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
517417001122	RNA binding site [nucleotide binding]; other site
517417001123	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
517417001124	GTPase/Zn-binding domain interface [polypeptide binding]; other site
517417001125	GTP/Mg2+ binding site [chemical binding]; other site
517417001126	G4 box; other site
517417001127	G5 box; other site
517417001128	G1 box; other site
517417001129	Switch I region; other site
517417001130	G2 box; other site
517417001131	G3 box; other site
517417001132	Switch II region; other site
517417001133	putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968
517417001134	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
517417001135	NAD(P) binding site [chemical binding]; other site
517417001136	catalytic residues [active]
517417001137	Domain of unknown function (DUF1848); Region: DUF1848; pfam08902
517417001138	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
517417001139	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
517417001140	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
517417001141	Low molecular weight phosphatase family; Region: LMWPc; cd00115
517417001142	active site
517417001143	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
517417001144	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
517417001145	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991
517417001146	Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562
517417001147	Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635
517417001148	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
517417001149	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
517417001150	glutamine binding [chemical binding]; other site
517417001151	catalytic triad [active]
517417001152	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
517417001153	Haem-binding domain; Region: Haem_bd; pfam14376
517417001154	Predicted transcriptional regulator [General function prediction only]; Region: COG2522
517417001155	non-specific DNA binding site [nucleotide binding]; other site
517417001156	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
517417001157	salt bridge; other site
517417001158	sequence-specific DNA binding site [nucleotide binding]; other site
517417001159	ResB-like family; Region: ResB; pfam05140
517417001160	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
517417001161	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
517417001162	Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079
517417001163	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
517417001164	stationary phase survival protein SurE; Provisional; Region: PRK13932
517417001165	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
517417001166	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
517417001167	active site
517417001168	nucleophile elbow; other site
517417001169	Surface antigen; Region: Bac_surface_Ag; pfam01103
517417001170	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
517417001171	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
517417001172	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
517417001173	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
517417001174	Clp protease; Region: CLP_protease; pfam00574
517417001175	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
517417001176	oligomer interface [polypeptide binding]; other site
517417001177	active site residues [active]
517417001178	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
517417001179	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
517417001180	active site
517417001181	HIGH motif; other site
517417001182	nucleotide binding site [chemical binding]; other site
517417001183	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
517417001184	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
517417001185	active site
517417001186	KMSKS motif; other site
517417001187	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
517417001188	tRNA binding surface [nucleotide binding]; other site
517417001189	anticodon binding site; other site
517417001190	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
517417001191	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
517417001192	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
517417001193	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
517417001194	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
517417001195	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
517417001196	DNA binding residues [nucleotide binding]
517417001197	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
517417001198	Predicted permeases [General function prediction only]; Region: COG0795
517417001199	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
517417001200	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
517417001201	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
517417001202	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
517417001203	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
517417001204	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
517417001205	Pleckstrin homology-like domain; Region: PH-like; cl17171
517417001206	excinuclease ABC subunit B; Provisional; Region: PRK05298
517417001207	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
517417001208	ATP binding site [chemical binding]; other site
517417001209	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
517417001210	putative Mg++ binding site [ion binding]; other site
517417001211	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
517417001212	nucleotide binding region [chemical binding]; other site
517417001213	ATP-binding site [chemical binding]; other site
517417001214	Ultra-violet resistance protein B; Region: UvrB; pfam12344
517417001215	UvrB/uvrC motif; Region: UVR; pfam02151
517417001216	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
517417001217	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
517417001218	Zn2+ binding site [ion binding]; other site
517417001219	Mg2+ binding site [ion binding]; other site
517417001220	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
517417001221	synthetase active site [active]
517417001222	NTP binding site [chemical binding]; other site
517417001223	metal binding site [ion binding]; metal-binding site
517417001224	Protein with unknown function (DUF469); Region: DUF469; cl01237
517417001225	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
517417001226	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
517417001227	Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948
517417001228	active site
517417001229	intersubunit interface [polypeptide binding]; other site
517417001230	catalytic residue [active]
517417001231	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
517417001232	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
517417001233	Repair protein; Region: Repair_PSII; pfam04536
517417001234	Repair protein; Region: Repair_PSII; cl01535
517417001235	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
517417001236	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
517417001237	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
517417001238	Domain of unknown function DUF59; Region: DUF59; pfam01883
517417001239	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
517417001240	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
517417001241	GTP-binding protein Der; Reviewed; Region: PRK00093
517417001242	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
517417001243	G1 box; other site
517417001244	GTP/Mg2+ binding site [chemical binding]; other site
517417001245	Switch I region; other site
517417001246	G2 box; other site
517417001247	Switch II region; other site
517417001248	G3 box; other site
517417001249	G4 box; other site
517417001250	G5 box; other site
517417001251	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
517417001252	G1 box; other site
517417001253	GTP/Mg2+ binding site [chemical binding]; other site
517417001254	Switch I region; other site
517417001255	G2 box; other site
517417001256	G3 box; other site
517417001257	Switch II region; other site
517417001258	G4 box; other site
517417001259	G5 box; other site
517417001260	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
517417001261	23S rRNA interface [nucleotide binding]; other site
517417001262	L3 interface [polypeptide binding]; other site
517417001263	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
517417001264	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
517417001265	rRNA interaction site [nucleotide binding]; other site
517417001266	S8 interaction site; other site
517417001267	putative laminin-1 binding site; other site
517417001268	elongation factor Ts; Provisional; Region: tsf; PRK09377
517417001269	UBA/TS-N domain; Region: UBA; pfam00627
517417001270	Elongation factor TS; Region: EF_TS; pfam00889
517417001271	Elongation factor TS; Region: EF_TS; pfam00889
517417001272	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
517417001273	putative nucleotide binding site [chemical binding]; other site
517417001274	uridine monophosphate binding site [chemical binding]; other site
517417001275	homohexameric interface [polypeptide binding]; other site
517417001276	recombination regulator RecX; Reviewed; Region: recX; PRK00117
517417001277	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
517417001278	B12 binding site [chemical binding]; other site
517417001279	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
517417001280	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517417001281	FeS/SAM binding site; other site
517417001282	2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284
517417001283	short chain dehydrogenase; Validated; Region: PRK08324
517417001284	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
517417001285	rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943
517417001286	putative NAD(P) binding site [chemical binding]; other site
517417001287	active site
517417001288	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
517417001289	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
517417001290	putative active site; other site
517417001291	catalytic residue [active]
517417001292	Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232
517417001293	ribulose bisphosphate carboxylase, type III; Region: rubisco_III; TIGR03326
517417001294	dimer interface [polypeptide binding]; other site
517417001295	catalytic residue [active]
517417001296	metal binding site [ion binding]; metal-binding site
517417001297	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
517417001298	classical (c) SDRs; Region: SDR_c; cd05233
517417001299	NAD(P) binding site [chemical binding]; other site
517417001300	active site
517417001301	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
517417001302	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
517417001303	classical (c) SDRs; Region: SDR_c; cd05233
517417001304	NAD(P) binding site [chemical binding]; other site
517417001305	active site
517417001306	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
517417001307	molybdenum-pterin binding domain; Region: Mop; TIGR00638
517417001308	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
517417001309	amphipathic channel; other site
517417001310	Asn-Pro-Ala signature motifs; other site
517417001311	ATP-binding cassette domain of the molybdenum transport system; Region: ABC_ModC_molybdenum_transporter; cd03297
517417001312	molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142
517417001313	Walker A/P-loop; other site
517417001314	ATP binding site [chemical binding]; other site
517417001315	Q-loop/lid; other site
517417001316	ABC transporter signature motif; other site
517417001317	Walker B; other site
517417001318	D-loop; other site
517417001319	H-loop/switch region; other site
517417001320	TOBE domain; Region: TOBE; cl01440
517417001321	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
517417001322	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
517417001323	dimer interface [polypeptide binding]; other site
517417001324	conserved gate region; other site
517417001325	putative PBP binding loops; other site
517417001326	ABC-ATPase subunit interface; other site
517417001327	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
517417001328	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
517417001329	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
517417001330	ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573
517417001331	dimerization interface [polypeptide binding]; other site
517417001332	active site
517417001333	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
517417001334	putative DNA binding site [nucleotide binding]; other site
517417001335	putative Zn2+ binding site [ion binding]; other site
517417001336	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
517417001337	Predicted permeases [General function prediction only]; Region: COG0701
517417001338	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
517417001339	Low molecular weight phosphatase family; Region: LMWPc; cd00115
517417001340	active site
517417001341	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
517417001342	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
517417001343	Walker A/P-loop; other site
517417001344	ATP binding site [chemical binding]; other site
517417001345	Q-loop/lid; other site
517417001346	ABC transporter signature motif; other site
517417001347	Walker B; other site
517417001348	D-loop; other site
517417001349	H-loop/switch region; other site
517417001350	Domain of unknown function DUF77; Region: DUF77; cl00307
517417001351	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
517417001352	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
517417001353	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
517417001354	nucleotide binding pocket [chemical binding]; other site
517417001355	K-X-D-G motif; other site
517417001356	catalytic site [active]
517417001357	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
517417001358	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
517417001359	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
517417001360	Dimer interface [polypeptide binding]; other site
517417001361	BRCT sequence motif; other site
517417001362	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
517417001363	four helix bundle suffix domain; Region: 4helix_suffix; TIGR04258
517417001364	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
517417001365	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517417001366	S-adenosylmethionine binding site [chemical binding]; other site
517417001367	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
517417001368	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
517417001369	HlyD family secretion protein; Region: HlyD_3; pfam13437
517417001370	Ferrochelatase; Region: Ferrochelatase; pfam00762
517417001371	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
517417001372	C-terminal domain interface [polypeptide binding]; other site
517417001373	active site
517417001374	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
517417001375	active site
517417001376	Uncharacterized conserved protein [Function unknown]; Region: COG1432
517417001377	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
517417001378	putative metal binding site [ion binding]; other site
517417001379	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
517417001380	Predicted permeases [General function prediction only]; Region: COG0679
517417001381	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
517417001382	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
517417001383	Walker A/P-loop; other site
517417001384	ATP binding site [chemical binding]; other site
517417001385	Q-loop/lid; other site
517417001386	ABC transporter signature motif; other site
517417001387	Walker B; other site
517417001388	D-loop; other site
517417001389	H-loop/switch region; other site
517417001390	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
517417001391	cobalt transport protein CbiM; Validated; Region: PRK06265
517417001392	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
517417001393	PDGLE domain; Region: PDGLE; pfam13190
517417001394	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
517417001395	nickel responsive regulator; Provisional; Region: PRK04460
517417001396	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
517417001397	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
517417001398	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
517417001399	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
517417001400	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
517417001401	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
517417001402	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
517417001403	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
517417001404	FAD binding pocket [chemical binding]; other site
517417001405	FAD binding motif [chemical binding]; other site
517417001406	phosphate binding motif [ion binding]; other site
517417001407	beta-alpha-beta structure motif; other site
517417001408	NAD binding pocket [chemical binding]; other site
517417001409	Iron coordination center [ion binding]; other site
517417001410	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181
517417001411	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
517417001412	putative active site [active]
517417001413	oxyanion strand; other site
517417001414	catalytic triad [active]
517417001415	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
517417001416	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
517417001417	catalytic residues [active]
517417001418	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
517417001419	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
517417001420	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
517417001421	RNA binding surface [nucleotide binding]; other site
517417001422	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
517417001423	active site
517417001424	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
517417001425	MarC family integral membrane protein; Region: MarC; pfam01914
517417001426	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517417001427	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
517417001428	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
517417001429	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
517417001430	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
517417001431	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
517417001432	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
517417001433	aminodeoxychorismate synthase; Provisional; Region: PRK07508
517417001434	aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553
517417001435	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
517417001436	homodimer interface [polypeptide binding]; other site
517417001437	substrate-cofactor binding pocket; other site
517417001438	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517417001439	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
517417001440	catalytic residue [active]
517417001441	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
517417001442	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
517417001443	minor groove reading motif; other site
517417001444	helix-hairpin-helix signature motif; other site
517417001445	substrate binding pocket [chemical binding]; other site
517417001446	active site
517417001447	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
517417001448	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
517417001449	putative RNA binding site [nucleotide binding]; other site
517417001450	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
517417001451	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
517417001452	motif II; other site
517417001453	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
517417001454	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
517417001455	Walker A/P-loop; other site
517417001456	ATP binding site [chemical binding]; other site
517417001457	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
517417001458	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
517417001459	ABC transporter signature motif; other site
517417001460	Walker B; other site
517417001461	D-loop; other site
517417001462	H-loop/switch region; other site
517417001463	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
517417001464	dihydropteroate synthase; Region: DHPS; TIGR01496
517417001465	substrate binding pocket [chemical binding]; other site
517417001466	dimer interface [polypeptide binding]; other site
517417001467	inhibitor binding site; inhibition site
517417001468	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
517417001469	Peptidase family M50; Region: Peptidase_M50; pfam02163
517417001470	active site
517417001471	putative substrate binding region [chemical binding]; other site
517417001472	Haem-binding domain; Region: Haem_bd; pfam14376
517417001473	Methyltransferase domain; Region: Methyltransf_25; pfam13649
517417001474	Rrf2 family protein; Region: rrf2_super; TIGR00738
517417001475	Transcriptional regulator; Region: Rrf2; pfam02082
517417001476	4Fe-4S binding domain; Region: Fer4_6; pfam12837
517417001477	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
517417001478	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517417001479	binding surface
517417001480	TPR motif; other site
517417001481	hybrid cluster protein; Provisional; Region: PRK05290
517417001482	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
517417001483	ACS interaction site; other site
517417001484	CODH interaction site; other site
517417001485	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
517417001486	hybrid metal cluster; other site
517417001487	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
517417001488	bile acid transporter; Region: bass; TIGR00841
517417001489	Sodium Bile acid symporter family; Region: SBF; pfam01758
517417001490	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
517417001491	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
517417001492	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517417001493	FeS/SAM binding site; other site
517417001494	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
517417001495	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
517417001496	motif II; other site
517417001497	PAS fold; Region: PAS_3; pfam08447
517417001498	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517417001499	putative active site [active]
517417001500	heme pocket [chemical binding]; other site
517417001501	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517417001502	dimer interface [polypeptide binding]; other site
517417001503	phosphorylation site [posttranslational modification]
517417001504	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517417001505	ATP binding site [chemical binding]; other site
517417001506	Mg2+ binding site [ion binding]; other site
517417001507	G-X-G motif; other site
517417001508	Response regulator receiver domain; Region: Response_reg; pfam00072
517417001509	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517417001510	active site
517417001511	phosphorylation site [posttranslational modification]
517417001512	intermolecular recognition site; other site
517417001513	dimerization interface [polypeptide binding]; other site
517417001514	Major Facilitator Superfamily; Region: MFS_1; pfam07690
517417001515	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782
517417001516	active site
517417001517	catalytic site [active]
517417001518	substrate binding site [chemical binding]; other site
517417001519	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108
517417001520	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
517417001521	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
517417001522	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
517417001523	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
517417001524	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
517417001525	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
517417001526	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
517417001527	plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647
517417001528	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
517417001529	Soluble P-type ATPase [General function prediction only]; Region: COG4087
517417001530	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
517417001531	pyruvate phosphate dikinase; Provisional; Region: PRK09279
517417001532	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
517417001533	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
517417001534	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
517417001535	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
517417001536	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
517417001537	TM-ABC transporter signature motif; other site
517417001538	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
517417001539	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
517417001540	conserved cys residue [active]
517417001541	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; pfam09603
517417001542	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
517417001543	Isochorismatase family; Region: Isochorismatase; pfam00857
517417001544	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
517417001545	catalytic triad [active]
517417001546	dimer interface [polypeptide binding]; other site
517417001547	conserved cis-peptide bond; other site
517417001548	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
517417001549	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
517417001550	putative acyl-acceptor binding pocket; other site
517417001551	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
517417001552	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
517417001553	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
517417001554	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
517417001555	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
517417001556	MPN+ (JAMM) motif; other site
517417001557	Zinc-binding site [ion binding]; other site
517417001558	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
517417001559	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
517417001560	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
517417001561	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
517417001562	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
517417001563	active site
517417001564	ribulose/triose binding site [chemical binding]; other site
517417001565	phosphate binding site [ion binding]; other site
517417001566	substrate (anthranilate) binding pocket [chemical binding]; other site
517417001567	product (indole) binding pocket [chemical binding]; other site
517417001568	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
517417001569	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
517417001570	substrate binding site [chemical binding]; other site
517417001571	hexamer interface [polypeptide binding]; other site
517417001572	metal binding site [ion binding]; metal-binding site
517417001573	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
517417001574	Surface antigen; Region: Bac_surface_Ag; pfam01103
517417001575	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
517417001576	DNA polymerase I; Provisional; Region: PRK05755
517417001577	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
517417001578	active site
517417001579	metal binding site 1 [ion binding]; metal-binding site
517417001580	putative 5' ssDNA interaction site; other site
517417001581	metal binding site 3; metal-binding site
517417001582	metal binding site 2 [ion binding]; metal-binding site
517417001583	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
517417001584	putative DNA binding site [nucleotide binding]; other site
517417001585	putative metal binding site [ion binding]; other site
517417001586	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
517417001587	active site
517417001588	catalytic site [active]
517417001589	substrate binding site [chemical binding]; other site
517417001590	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
517417001591	active site
517417001592	DNA binding site [nucleotide binding]
517417001593	catalytic site [active]
517417001594	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
517417001595	Prephenate dehydratase; Region: PDT; pfam00800
517417001596	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
517417001597	putative L-Phe binding site [chemical binding]; other site
517417001598	hypothetical protein; Validated; Region: PRK00110
517417001599	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
517417001600	active site
517417001601	putative DNA-binding cleft [nucleotide binding]; other site
517417001602	dimer interface [polypeptide binding]; other site
517417001603	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
517417001604	bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188
517417001605	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
517417001606	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
517417001607	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
517417001608	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
517417001609	active site
517417001610	dimerization interface [polypeptide binding]; other site
517417001611	TspO/MBR family; Region: TspO_MBR; pfam03073
517417001612	Putative addiction module component; Region: Unstab_antitox; pfam09720
517417001613	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
517417001614	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
517417001615	dimer interface [polypeptide binding]; other site
517417001616	[2Fe-2S] cluster binding site [ion binding]; other site
517417001617	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
517417001618	dimerization interface [polypeptide binding]; other site
517417001619	putative DNA binding site [nucleotide binding]; other site
517417001620	putative Zn2+ binding site [ion binding]; other site
517417001621	acetyl-CoA synthetase; Provisional; Region: PRK00174
517417001622	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
517417001623	active site
517417001624	CoA binding site [chemical binding]; other site
517417001625	acyl-activating enzyme (AAE) consensus motif; other site
517417001626	AMP binding site [chemical binding]; other site
517417001627	acetate binding site [chemical binding]; other site
517417001628	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
517417001629	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
517417001630	HIGH motif; other site
517417001631	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
517417001632	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
517417001633	active site
517417001634	KMSKS motif; other site
517417001635	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
517417001636	tRNA binding surface [nucleotide binding]; other site
517417001637	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
517417001638	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
517417001639	RNase E interface [polypeptide binding]; other site
517417001640	trimer interface [polypeptide binding]; other site
517417001641	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
517417001642	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
517417001643	RNase E interface [polypeptide binding]; other site
517417001644	trimer interface [polypeptide binding]; other site
517417001645	active site
517417001646	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
517417001647	putative nucleic acid binding region [nucleotide binding]; other site
517417001648	G-X-X-G motif; other site
517417001649	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
517417001650	RNA binding site [nucleotide binding]; other site
517417001651	domain interface; other site
517417001652	Pantoate-beta-alanine ligase; Region: PanC; cd00560
517417001653	pantoate--beta-alanine ligase; Region: panC; TIGR00018
517417001654	active site
517417001655	ATP-binding site [chemical binding]; other site
517417001656	pantoate-binding site; other site
517417001657	HXXH motif; other site
517417001658	Predicted methyltransferases [General function prediction only]; Region: COG0313
517417001659	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
517417001660	putative SAM binding site [chemical binding]; other site
517417001661	putative homodimer interface [polypeptide binding]; other site
517417001662	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
517417001663	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
517417001664	Walker A/P-loop; other site
517417001665	ATP binding site [chemical binding]; other site
517417001666	Q-loop/lid; other site
517417001667	ABC transporter signature motif; other site
517417001668	Walker B; other site
517417001669	D-loop; other site
517417001670	H-loop/switch region; other site
517417001671	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
517417001672	signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705
517417001673	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
517417001674	tandem repeat interface [polypeptide binding]; other site
517417001675	oligomer interface [polypeptide binding]; other site
517417001676	active site residues [active]
517417001677	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
517417001678	tandem repeat interface [polypeptide binding]; other site
517417001679	oligomer interface [polypeptide binding]; other site
517417001680	active site residues [active]
517417001681	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
517417001682	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
517417001683	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517417001684	Walker A motif; other site
517417001685	ATP binding site [chemical binding]; other site
517417001686	Walker B motif; other site
517417001687	arginine finger; other site
517417001688	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
517417001689	Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075
517417001690	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
517417001691	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
517417001692	Photosystem P840 reaction-centre cytochrome c-551; Region: Cytochrome-c551; pfam10643
517417001693	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
517417001694	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
517417001695	active site
517417001696	Putative methyltransferase; Region: Methyltransf_16; pfam10294
517417001697	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
517417001698	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
517417001699	active site
517417001700	Int/Topo IB signature motif; other site
517417001701	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
517417001702	30S subunit binding site; other site
517417001703	HPr kinase/phosphorylase; Provisional; Region: PRK05428
517417001704	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
517417001705	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
517417001706	Hpr binding site; other site
517417001707	active site
517417001708	homohexamer subunit interaction site [polypeptide binding]; other site
517417001709	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
517417001710	The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514
517417001711	peptide binding site [polypeptide binding]; other site
517417001712	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
517417001713	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
517417001714	dimer interface [polypeptide binding]; other site
517417001715	conserved gate region; other site
517417001716	putative PBP binding loops; other site
517417001717	ABC-ATPase subunit interface; other site
517417001718	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
517417001719	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517417001720	Walker A motif; other site
517417001721	ATP binding site [chemical binding]; other site
517417001722	Walker B motif; other site
517417001723	arginine finger; other site
517417001724	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
517417001725	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517417001726	TPR motif; other site
517417001727	binding surface
517417001728	TPR repeat; Region: TPR_11; pfam13414
517417001729	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517417001730	binding surface
517417001731	TPR motif; other site
517417001732	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
517417001733	binding surface
517417001734	TPR motif; other site
517417001735	TPR repeat; Region: TPR_11; pfam13414
517417001736	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517417001737	binding surface
517417001738	TPR motif; other site
517417001739	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
517417001740	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
517417001741	dimer interface [polypeptide binding]; other site
517417001742	PYR/PP interface [polypeptide binding]; other site
517417001743	TPP binding site [chemical binding]; other site
517417001744	substrate binding site [chemical binding]; other site
517417001745	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
517417001746	Domain of unknown function; Region: EKR; pfam10371
517417001747	4Fe-4S binding domain; Region: Fer4_6; pfam12837
517417001748	4Fe-4S binding domain; Region: Fer4; pfam00037
517417001749	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
517417001750	TPP-binding site [chemical binding]; other site
517417001751	dimer interface [polypeptide binding]; other site
517417001752	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
517417001753	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
517417001754	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
517417001755	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
517417001756	lipoyl attachment site [posttranslational modification]; other site
517417001757	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
517417001758	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
517417001759	tetramer interface [polypeptide binding]; other site
517417001760	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517417001761	catalytic residue [active]
517417001762	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
517417001763	dihydrodipicolinate synthase; Region: dapA; TIGR00674
517417001764	dimer interface [polypeptide binding]; other site
517417001765	active site
517417001766	catalytic residue [active]
517417001767	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
517417001768	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
517417001769	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
517417001770	Walker A/P-loop; other site
517417001771	ATP binding site [chemical binding]; other site
517417001772	Q-loop/lid; other site
517417001773	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
517417001774	ABC transporter signature motif; other site
517417001775	Walker B; other site
517417001776	D-loop; other site
517417001777	H-loop/switch region; other site
517417001778	Lamin Tail Domain; Region: LTD; pfam00932
517417001779	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
517417001780	twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411
517417001781	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
517417001782	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
517417001783	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
517417001784	Ligand Binding Site [chemical binding]; other site
517417001785	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
517417001786	RNA/DNA hybrid binding site [nucleotide binding]; other site
517417001787	active site
517417001788	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
517417001789	bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566
517417001790	UbiA prenyltransferase family; Region: UbiA; pfam01040
517417001791	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
517417001792	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
517417001793	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
517417001794	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
517417001795	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
517417001796	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
517417001797	active site
517417001798	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
517417001799	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
517417001800	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
517417001801	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
517417001802	hinge; other site
517417001803	active site
517417001804	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
517417001805	Peptidase family M23; Region: Peptidase_M23; pfam01551
517417001806	NAD synthetase; Provisional; Region: PRK13980
517417001807	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
517417001808	homodimer interface [polypeptide binding]; other site
517417001809	NAD binding pocket [chemical binding]; other site
517417001810	ATP binding pocket [chemical binding]; other site
517417001811	Mg binding site [ion binding]; other site
517417001812	active-site loop [active]
517417001813	L-aspartate oxidase; Provisional; Region: PRK09077
517417001814	L-aspartate oxidase; Provisional; Region: PRK06175
517417001815	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
517417001816	pyruvoyl-dependent arginine decarboxylase; Reviewed; Region: PRK01285
517417001817	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
517417001818	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
517417001819	active site
517417001820	HIGH motif; other site
517417001821	dimer interface [polypeptide binding]; other site
517417001822	KMSKS motif; other site
517417001823	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
517417001824	RNA binding surface [nucleotide binding]; other site
517417001825	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
517417001826	SmpB-tmRNA interface; other site
517417001827	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
517417001828	FAD binding domain; Region: FAD_binding_4; pfam01565
517417001829	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
517417001830	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
517417001831	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
517417001832	rod shape-determining protein MreC; Provisional; Region: PRK13922
517417001833	rod shape-determining protein MreC; Region: MreC; pfam04085
517417001834	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
517417001835	oligomerisation interface [polypeptide binding]; other site
517417001836	mobile loop; other site
517417001837	roof hairpin; other site
517417001838	quinolinate synthetase; Provisional; Region: PRK09375
517417001839	Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915
517417001840	Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915
517417001841	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
517417001842	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517417001843	NAD(P) binding site [chemical binding]; other site
517417001844	active site
517417001845	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
517417001846	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
517417001847	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
517417001848	Transcriptional regulator; Region: Transcrip_reg; cl00361
517417001849	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
517417001850	active site
517417001851	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
517417001852	TSCPD domain; Region: TSCPD; pfam12637
517417001853	toxin interface [polypeptide binding]; other site
517417001854	putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830
517417001855	YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831
517417001856	Zn binding site [ion binding]; other site
517417001857	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
517417001858	non-specific DNA binding site [nucleotide binding]; other site
517417001859	salt bridge; other site
517417001860	sequence-specific DNA binding site [nucleotide binding]; other site
517417001861	Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869
517417001862	peptide binding site [polypeptide binding]; other site
517417001863	Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682
517417001864	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
517417001865	nucleoside/Zn binding site; other site
517417001866	dimer interface [polypeptide binding]; other site
517417001867	catalytic motif [active]
517417001868	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
517417001869	Lumazine-binding domain; Region: Lumazine_bd; pfam12870
517417001870	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
517417001871	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
517417001872	Walker A/P-loop; other site
517417001873	ATP binding site [chemical binding]; other site
517417001874	Q-loop/lid; other site
517417001875	ABC transporter signature motif; other site
517417001876	Walker B; other site
517417001877	D-loop; other site
517417001878	H-loop/switch region; other site
517417001879	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
517417001880	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
517417001881	Domain of unknown function (DUF4293); Region: DUF4293; pfam14126
517417001882	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
517417001883	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
517417001884	Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951
517417001885	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
517417001886	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
517417001887	DEAD-like helicases superfamily; Region: DEXDc; smart00487
517417001888	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
517417001889	ATP binding site [chemical binding]; other site
517417001890	Mg++ binding site [ion binding]; other site
517417001891	motif III; other site
517417001892	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
517417001893	nucleotide binding region [chemical binding]; other site
517417001894	ATP-binding site [chemical binding]; other site
517417001895	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
517417001896	putative RNA binding site [nucleotide binding]; other site
517417001897	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
517417001898	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
517417001899	Beta-Casp domain; Region: Beta-Casp; smart01027
517417001900	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
517417001901	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
517417001902	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
517417001903	substrate binding site [chemical binding]; other site
517417001904	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
517417001905	hypothetical protein; Reviewed; Region: PRK09588
517417001906	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
517417001907	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
517417001908	active site
517417001909	Int/Topo IB signature motif; other site
517417001910	16S rRNA methyltransferase B; Provisional; Region: PRK14904
517417001911	NusB family; Region: NusB; pfam01029
517417001912	putative RNA binding site [nucleotide binding]; other site
517417001913	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517417001914	S-adenosylmethionine binding site [chemical binding]; other site
517417001915	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
517417001916	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
517417001917	homodimer interface [polypeptide binding]; other site
517417001918	substrate-cofactor binding pocket; other site
517417001919	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517417001920	catalytic residue [active]
517417001921	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
517417001922	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
517417001923	seryl-tRNA synthetase; Provisional; Region: PRK05431
517417001924	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
517417001925	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
517417001926	dimer interface [polypeptide binding]; other site
517417001927	active site
517417001928	motif 1; other site
517417001929	motif 2; other site
517417001930	motif 3; other site
517417001931	Yqey-like protein; Region: YqeY; pfam09424
517417001932	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
517417001933	classical (c) SDRs; Region: SDR_c; cd05233
517417001934	NAD(P) binding site [chemical binding]; other site
517417001935	active site
517417001936	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
517417001937	DNA-binding site [nucleotide binding]; DNA binding site
517417001938	RNA-binding motif; other site
517417001939	hypothetical protein; Reviewed; Region: PRK00024
517417001940	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
517417001941	helix-hairpin-helix signature motif; other site
517417001942	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
517417001943	MPN+ (JAMM) motif; other site
517417001944	Zinc-binding site [ion binding]; other site
517417001945	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
517417001946	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
517417001947	active site
517417001948	catalytic residues [active]
517417001949	metal binding site [ion binding]; metal-binding site
517417001950	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
517417001951	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
517417001952	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
517417001953	substrate binding site [chemical binding]; other site
517417001954	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
517417001955	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
517417001956	substrate binding site [chemical binding]; other site
517417001957	ligand binding site [chemical binding]; other site
517417001958	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
517417001959	tartrate dehydrogenase; Region: TTC; TIGR02089
517417001960	ketol-acid reductoisomerase; Provisional; Region: PRK05479
517417001961	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
517417001962	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
517417001963	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
517417001964	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
517417001965	putative valine binding site [chemical binding]; other site
517417001966	dimer interface [polypeptide binding]; other site
517417001967	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
517417001968	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
517417001969	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
517417001970	PYR/PP interface [polypeptide binding]; other site
517417001971	dimer interface [polypeptide binding]; other site
517417001972	TPP binding site [chemical binding]; other site
517417001973	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368
517417001974	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
517417001975	TPP-binding site [chemical binding]; other site
517417001976	dimer interface [polypeptide binding]; other site
517417001977	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
517417001978	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
517417001979	Integral membrane protein DUF92; Region: DUF92; pfam01940
517417001980	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
517417001981	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
517417001982	TolR protein; Region: tolR; TIGR02801
517417001983	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
517417001984	TonB C terminal; Region: TonB_2; pfam13103
517417001985	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
517417001986	TolB amino-terminal domain; Region: TolB_N; pfam04052
517417001987	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
517417001988	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
517417001989	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
517417001990	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
517417001991	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
517417001992	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
517417001993	ligand binding site [chemical binding]; other site
517417001994	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
517417001995	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
517417001996	ligand binding site [chemical binding]; other site
517417001997	Protein of unknown function (DUF3251); Region: DUF3251; cl08186
517417001998	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517417001999	binding surface
517417002000	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
517417002001	TPR motif; other site
517417002002	Photosystem P840 reaction centre protein PscD; Region: RC-P840_PscD; pfam10657
517417002003	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
517417002004	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
517417002005	nucleotide binding site [chemical binding]; other site
517417002006	NEF interaction site [polypeptide binding]; other site
517417002007	SBD interface [polypeptide binding]; other site
517417002008	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
517417002009	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
517417002010	putative dimer interface [polypeptide binding]; other site
517417002011	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
517417002012	dimerization interface [polypeptide binding]; other site
517417002013	putative DNA binding site [nucleotide binding]; other site
517417002014	putative Zn2+ binding site [ion binding]; other site
517417002015	Putative zinc-finger; Region: zf-HC2; pfam13490
517417002016	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
517417002017	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
517417002018	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
517417002019	DNA binding residues [nucleotide binding]
517417002020	carotene isomerase; Region: carot_isom; TIGR02730
517417002021	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
517417002022	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
517417002023	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
517417002024	hexamer interface [polypeptide binding]; other site
517417002025	ligand binding site [chemical binding]; other site
517417002026	putative active site [active]
517417002027	NAD(P) binding site [chemical binding]; other site
517417002028	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
517417002029	catalytic loop [active]
517417002030	iron binding site [ion binding]; other site
517417002031	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
517417002032	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
517417002033	catalytic loop [active]
517417002034	iron binding site [ion binding]; other site
517417002035	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
517417002036	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
517417002037	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
517417002038	ATP binding site [chemical binding]; other site
517417002039	putative Mg++ binding site [ion binding]; other site
517417002040	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
517417002041	nucleotide binding region [chemical binding]; other site
517417002042	ATP-binding site [chemical binding]; other site
517417002043	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
517417002044	Domain of unknown function (DUF1883); Region: DUF1883; pfam08980
517417002045	TIR domain; Region: TIR_2; pfam13676
517417002046	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
517417002047	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
517417002048	Walker A/P-loop; other site
517417002049	ATP binding site [chemical binding]; other site
517417002050	Q-loop/lid; other site
517417002051	ABC transporter signature motif; other site
517417002052	Walker B; other site
517417002053	D-loop; other site
517417002054	H-loop/switch region; other site
517417002055	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
517417002056	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
517417002057	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517417002058	active site
517417002059	phosphorylation site [posttranslational modification]
517417002060	intermolecular recognition site; other site
517417002061	dimerization interface [polypeptide binding]; other site
517417002062	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
517417002063	DNA binding site [nucleotide binding]
517417002064	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
517417002065	dimerization interface [polypeptide binding]; other site
517417002066	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
517417002067	PAS domain; Region: PAS; smart00091
517417002068	putative active site [active]
517417002069	heme pocket [chemical binding]; other site
517417002070	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517417002071	dimer interface [polypeptide binding]; other site
517417002072	phosphorylation site [posttranslational modification]
517417002073	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517417002074	ATP binding site [chemical binding]; other site
517417002075	Mg2+ binding site [ion binding]; other site
517417002076	G-X-G motif; other site
517417002077	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
517417002078	Mechanosensitive ion channel; Region: MS_channel; pfam00924
517417002079	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
517417002080	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
517417002081	nudix motif; other site
517417002082	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
517417002083	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
517417002084	catalytic triad [active]
517417002085	Uncharacterized ACR, COG1678; Region: DUF179; pfam02622
517417002086	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
517417002087	active site
517417002088	8-oxo-dGMP binding site [chemical binding]; other site
517417002089	nudix motif; other site
517417002090	metal binding site [ion binding]; metal-binding site
517417002091	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
517417002092	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
517417002093	ATP binding site [chemical binding]; other site
517417002094	putative Mg++ binding site [ion binding]; other site
517417002095	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
517417002096	nucleotide binding region [chemical binding]; other site
517417002097	ATP-binding site [chemical binding]; other site
517417002098	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
517417002099	HRDC domain; Region: HRDC; pfam00570
517417002100	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
517417002101	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
517417002102	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
517417002103	ATP binding site [chemical binding]; other site
517417002104	substrate interface [chemical binding]; other site
517417002105	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
517417002106	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517417002107	FeS/SAM binding site; other site
517417002108	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
517417002109	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
517417002110	ThiS interaction site; other site
517417002111	putative active site [active]
517417002112	tetramer interface [polypeptide binding]; other site
517417002113	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
517417002114	thiS-thiF/thiG interaction site; other site
517417002115	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
517417002116	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
517417002117	dimer interface [polypeptide binding]; other site
517417002118	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517417002119	catalytic residue [active]
517417002120	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
517417002121	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
517417002122	homodimer interface [polypeptide binding]; other site
517417002123	substrate-cofactor binding pocket; other site
517417002124	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517417002125	catalytic residue [active]
517417002126	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
517417002127	Protein of unknown function DUF45; Region: DUF45; pfam01863
517417002128	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
517417002129	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
517417002130	hexamer interface [polypeptide binding]; other site
517417002131	ligand binding site [chemical binding]; other site
517417002132	putative active site [active]
517417002133	NAD(P) binding site [chemical binding]; other site
517417002134	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
517417002135	trimer interface [polypeptide binding]; other site
517417002136	putative Zn binding site [ion binding]; other site
517417002137	TspO/MBR family; Region: TspO_MBR; cl01379
517417002138	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
517417002139	putative transporter; Provisional; Region: PRK11660
517417002140	Sulfate transporter family; Region: Sulfate_transp; pfam00916
517417002141	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
517417002142	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
517417002143	putative cation:proton antiport protein; Provisional; Region: PRK10669
517417002144	TrkA-N domain; Region: TrkA_N; pfam02254
517417002145	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
517417002146	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
517417002147	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
517417002148	active site
517417002149	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
517417002150	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
517417002151	NAD binding domain of methylene-tetrahydrofolate dehydrogenase; Region: NAD_bind_m-THF_DH; cd01079
517417002152	NAD binding site [chemical binding]; other site
517417002153	putative homodimer interface [polypeptide binding]; other site
517417002154	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
517417002155	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
517417002156	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
517417002157	homotetramer interface [polypeptide binding]; other site
517417002158	ligand binding site [chemical binding]; other site
517417002159	catalytic site [active]
517417002160	NAD binding site [chemical binding]; other site
517417002161	S-adenosylmethionine synthetase; Validated; Region: PRK05250
517417002162	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
517417002163	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
517417002164	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
517417002165	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
517417002166	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
517417002167	active site
517417002168	metal binding site [ion binding]; metal-binding site
517417002169	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
517417002170	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
517417002171	active site
517417002172	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
517417002173	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
517417002174	active site
517417002175	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
517417002176	putative trimer interface [polypeptide binding]; other site
517417002177	putative CoA binding site [chemical binding]; other site
517417002178	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
517417002179	nudix motif; other site
517417002180	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
517417002181	HlyD family secretion protein; Region: HlyD_3; pfam13437
517417002182	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
517417002183	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
517417002184	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
517417002185	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
517417002186	putative tRNA-binding site [nucleotide binding]; other site
517417002187	B3/4 domain; Region: B3_4; pfam03483
517417002188	tRNA synthetase B5 domain; Region: B5; smart00874
517417002189	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
517417002190	dimer interface [polypeptide binding]; other site
517417002191	motif 1; other site
517417002192	motif 3; other site
517417002193	motif 2; other site
517417002194	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
517417002195	Cell division protein ZapA; Region: ZapA; pfam05164
517417002196	phosphodiesterase; Provisional; Region: PRK12704
517417002197	KH domain; Region: KH_1; pfam00013
517417002198	uncharacterized domain HDIG; Region: HDIG; TIGR00277
517417002199	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
517417002200	putative active site pocket [active]
517417002201	4-fold oligomerization interface [polypeptide binding]; other site
517417002202	metal binding residues [ion binding]; metal-binding site
517417002203	3-fold/trimer interface [polypeptide binding]; other site
517417002204	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
517417002205	protein translocase, SecG subunit; Region: secG; TIGR00810
517417002206	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
517417002207	RNB domain; Region: RNB; pfam00773
517417002208	Uncharacterized protein family (UPF0259); Region: UPF0259; cl11642
517417002209	Predicted permeases [General function prediction only]; Region: COG0795
517417002210	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
517417002211	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
517417002212	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
517417002213	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
517417002214	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
517417002215	Domain of unknown function (DUF814); Region: DUF814; pfam05670
517417002216	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
517417002217	catalytic motif [active]
517417002218	Zn binding site [ion binding]; other site
517417002219	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
517417002220	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
517417002221	catalytic motif [active]
517417002222	Zn binding site [ion binding]; other site
517417002223	RibD C-terminal domain; Region: RibD_C; cl17279
517417002224	DoxX; Region: DoxX; pfam07681
517417002225	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
517417002226	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
517417002227	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
517417002228	ABC transporter; Region: ABC_tran_2; pfam12848
517417002229	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
517417002230	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
517417002231	A new structural DNA glycosylase; Region: AlkD_like; cd06561
517417002232	active site
517417002233	YXWGXW repeat (2 copies); Region: YXWGXW; pfam12779
517417002234	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
517417002235	STIM1 Orai1-activating region; Region: SOAR; cd11722
517417002236	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
517417002237	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
517417002238	B12 binding site [chemical binding]; other site
517417002239	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517417002240	FeS/SAM binding site; other site
517417002241	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
517417002242	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866
517417002243	putative hydrophobic ligand binding site [chemical binding]; other site
517417002244	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
517417002245	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
517417002246	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
517417002247	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
517417002248	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
517417002249	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
517417002250	RNA binding surface [nucleotide binding]; other site
517417002251	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
517417002252	active site
517417002253	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
517417002254	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
517417002255	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
517417002256	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
517417002257	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
517417002258	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
517417002259	Walker A motif; other site
517417002260	ATP binding site [chemical binding]; other site
517417002261	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517417002262	magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031
517417002263	Walker A motif; other site
517417002264	ATP binding site [chemical binding]; other site
517417002265	Walker B motif; other site
517417002266	arginine finger; other site
517417002267	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
517417002268	metal ion-dependent adhesion site (MIDAS); other site
517417002269	magnesium chelatase, H subunit; Region: BchH; TIGR02025
517417002270	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
517417002271	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
517417002272	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
517417002273	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
517417002274	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
517417002275	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
517417002276	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
517417002277	active site
517417002278	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
517417002279	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
517417002280	Tetramer interface [polypeptide binding]; other site
517417002281	active site
517417002282	FMN-binding site [chemical binding]; other site
517417002283	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
517417002284	dimer interface [polypeptide binding]; other site
517417002285	active site
517417002286	aspartate-rich active site metal binding site; other site
517417002287	allosteric magnesium binding site [ion binding]; other site
517417002288	Schiff base residues; other site
517417002289	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
517417002290	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
517417002291	active site
517417002292	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
517417002293	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
517417002294	domain interfaces; other site
517417002295	active site
517417002296	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
517417002297	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
517417002298	tRNA; other site
517417002299	putative tRNA binding site [nucleotide binding]; other site
517417002300	putative NADP binding site [chemical binding]; other site
517417002301	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
517417002302	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
517417002303	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
517417002304	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
517417002305	G1 box; other site
517417002306	putative GEF interaction site [polypeptide binding]; other site
517417002307	GTP/Mg2+ binding site [chemical binding]; other site
517417002308	Switch I region; other site
517417002309	G2 box; other site
517417002310	G3 box; other site
517417002311	Switch II region; other site
517417002312	G4 box; other site
517417002313	G5 box; other site
517417002314	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
517417002315	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
517417002316	chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016
517417002317	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
517417002318	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
517417002319	DNA binding residues [nucleotide binding]
517417002320	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202
517417002321	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
517417002322	putative NAD(P) binding site [chemical binding]; other site
517417002323	2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; cl06353
517417002324	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
517417002325	The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514
517417002326	peptide binding site [polypeptide binding]; other site
517417002327	bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001
517417002328	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
517417002329	trimer interface [polypeptide binding]; other site
517417002330	active site
517417002331	chlorosome envelope protein H repeat; Region: rpt_csmH; TIGR03058
517417002332	chlorosome envelope protein H repeat; Region: rpt_csmH; TIGR03058
517417002333	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
517417002334	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
517417002335	Probable Catalytic site; other site
517417002336	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
517417002337	phytoene desaturase; Region: phytoene_desat; TIGR02731
517417002338	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
517417002339	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
517417002340	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
517417002341	dimerization interface [polypeptide binding]; other site
517417002342	putative DNA binding site [nucleotide binding]; other site
517417002343	putative Zn2+ binding site [ion binding]; other site
517417002344	AsnC family; Region: AsnC_trans_reg; pfam01037
517417002345	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
517417002346	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
517417002347	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
517417002348	Uncharacterized conserved protein [Function unknown]; Region: COG0432
517417002349	pantothenate kinase; Reviewed; Region: PRK13320
517417002350	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
517417002351	active site
517417002352	dimer interface [polypeptide binding]; other site
517417002353	metal binding site [ion binding]; metal-binding site
517417002354	shikimate kinase; Reviewed; Region: aroK; PRK00131
517417002355	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
517417002356	ADP binding site [chemical binding]; other site
517417002357	magnesium binding site [ion binding]; other site
517417002358	putative shikimate binding site; other site
517417002359	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
517417002360	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
517417002361	catalytic triad [active]
517417002362	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
517417002363	AAA domain; Region: AAA_30; pfam13604
517417002364	Family description; Region: UvrD_C_2; pfam13538
517417002365	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
517417002366	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
517417002367	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
517417002368	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
517417002369	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517417002370	FeS/SAM binding site; other site
517417002371	TRAM domain; Region: TRAM; cl01282
517417002372	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
517417002373	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
517417002374	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517417002375	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
517417002376	putative active site [active]
517417002377	heme pocket [chemical binding]; other site
517417002378	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517417002379	putative active site [active]
517417002380	heme pocket [chemical binding]; other site
517417002381	GAF domain; Region: GAF_2; pfam13185
517417002382	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
517417002383	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
517417002384	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517417002385	dimer interface [polypeptide binding]; other site
517417002386	phosphorylation site [posttranslational modification]
517417002387	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517417002388	ATP binding site [chemical binding]; other site
517417002389	Mg2+ binding site [ion binding]; other site
517417002390	G-X-G motif; other site
517417002391	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
517417002392	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517417002393	active site
517417002394	phosphorylation site [posttranslational modification]
517417002395	intermolecular recognition site; other site
517417002396	dimerization interface [polypeptide binding]; other site
517417002397	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
517417002398	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
517417002399	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
517417002400	7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402
517417002401	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
517417002402	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
517417002403	Uncharacterized conserved protein [Function unknown]; Region: COG2308
517417002404	Divergent AAA domain; Region: AAA_4; pfam04326
517417002405	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
517417002406	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
517417002407	Cl- selectivity filter; other site
517417002408	Cl- binding residues [ion binding]; other site
517417002409	pore gating glutamate residue; other site
517417002410	dimer interface [polypeptide binding]; other site
517417002411	FOG: CBS domain [General function prediction only]; Region: COG0517
517417002412	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613
517417002413	Superinfection immunity protein; Region: Imm_superinfect; pfam14373
517417002414	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
517417002415	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
517417002416	dimer interface [polypeptide binding]; other site
517417002417	putative anticodon binding site; other site
517417002418	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
517417002419	motif 1; other site
517417002420	active site
517417002421	motif 2; other site
517417002422	motif 3; other site
517417002423	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
517417002424	active site lid residues [active]
517417002425	substrate binding pocket [chemical binding]; other site
517417002426	catalytic residues [active]
517417002427	substrate-Mg2+ binding site; other site
517417002428	aspartate-rich region 1; other site
517417002429	aspartate-rich region 2; other site
517417002430	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
517417002431	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
517417002432	HflX GTPase family; Region: HflX; cd01878
517417002433	G1 box; other site
517417002434	GTP/Mg2+ binding site [chemical binding]; other site
517417002435	Switch I region; other site
517417002436	G2 box; other site
517417002437	G3 box; other site
517417002438	Switch II region; other site
517417002439	G4 box; other site
517417002440	G5 box; other site
517417002441	probable rRNA maturation factor YbeY; Region: TIGR00043
517417002442	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
517417002443	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
517417002444	catalytic loop [active]
517417002445	iron binding site [ion binding]; other site
517417002446	hypothetical protein; Provisional; Region: PRK08912
517417002447	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
517417002448	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517417002449	homodimer interface [polypeptide binding]; other site
517417002450	catalytic residue [active]
517417002451	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
517417002452	PAS fold; Region: PAS_4; pfam08448
517417002453	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517417002454	putative active site [active]
517417002455	heme pocket [chemical binding]; other site
517417002456	PAS domain S-box; Region: sensory_box; TIGR00229
517417002457	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517417002458	putative active site [active]
517417002459	heme pocket [chemical binding]; other site
517417002460	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517417002461	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
517417002462	putative active site [active]
517417002463	heme pocket [chemical binding]; other site
517417002464	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517417002465	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
517417002466	putative active site [active]
517417002467	heme pocket [chemical binding]; other site
517417002468	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517417002469	dimer interface [polypeptide binding]; other site
517417002470	phosphorylation site [posttranslational modification]
517417002471	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517417002472	ATP binding site [chemical binding]; other site
517417002473	Mg2+ binding site [ion binding]; other site
517417002474	G-X-G motif; other site
517417002475	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
517417002476	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517417002477	active site
517417002478	phosphorylation site [posttranslational modification]
517417002479	intermolecular recognition site; other site
517417002480	dimerization interface [polypeptide binding]; other site
517417002481	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
517417002482	Putative zinc ribbon domain; Region: DUF164; pfam02591
517417002483	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
517417002484	diaminopimelate decarboxylase; Region: lysA; TIGR01048
517417002485	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
517417002486	active site
517417002487	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
517417002488	substrate binding site [chemical binding]; other site
517417002489	catalytic residues [active]
517417002490	dimer interface [polypeptide binding]; other site
517417002491	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
517417002492	putative ligand binding pocket/active site [active]
517417002493	putative metal binding site [ion binding]; other site
517417002494	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
517417002495	FAD binding site [chemical binding]; other site
517417002496	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
517417002497	Competence protein; Region: Competence; pfam03772
517417002498	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
517417002499	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
517417002500	dimer interface [polypeptide binding]; other site
517417002501	ADP-ribose binding site [chemical binding]; other site
517417002502	active site
517417002503	nudix motif; other site
517417002504	metal binding site [ion binding]; metal-binding site
517417002505	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
517417002506	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
517417002507	dimer interface [polypeptide binding]; other site
517417002508	conserved gate region; other site
517417002509	putative PBP binding loops; other site
517417002510	ABC-ATPase subunit interface; other site
517417002511	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
517417002512	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
517417002513	5S rRNA interface [nucleotide binding]; other site
517417002514	CTC domain interface [polypeptide binding]; other site
517417002515	L16 interface [polypeptide binding]; other site
517417002516	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
517417002517	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
517417002518	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
517417002519	active site
517417002520	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
517417002521	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
517417002522	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
517417002523	trimer interface [polypeptide binding]; other site
517417002524	active site
517417002525	UDP-GlcNAc binding site [chemical binding]; other site
517417002526	lipid binding site [chemical binding]; lipid-binding site
517417002527	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
517417002528	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
517417002529	Protein of unknown function, DUF547; Region: DUF547; pfam04784
517417002530	Cytidylyltransferase family; Region: CTP_transf_1; cl17467
517417002531	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
517417002532	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
517417002533	dimer interface [polypeptide binding]; other site
517417002534	phosphorylation site [posttranslational modification]
517417002535	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517417002536	ATP binding site [chemical binding]; other site
517417002537	G-X-G motif; other site
517417002538	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517417002539	active site
517417002540	phosphorylation site [posttranslational modification]
517417002541	intermolecular recognition site; other site
517417002542	Response regulator receiver domain; Region: Response_reg; pfam00072
517417002543	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517417002544	active site
517417002545	phosphorylation site [posttranslational modification]
517417002546	intermolecular recognition site; other site
517417002547	dimerization interface [polypeptide binding]; other site
517417002548	Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232
517417002549	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
517417002550	A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756
517417002551	SnoaL-like domain; Region: SnoaL_3; pfam13474
517417002552	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
517417002553	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
517417002554	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
517417002555	ligand binding site [chemical binding]; other site
517417002556	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
517417002557	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
517417002558	FtsX-like permease family; Region: FtsX; pfam02687
517417002559	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
517417002560	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
517417002561	FtsX-like permease family; Region: FtsX; pfam02687
517417002562	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
517417002563	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
517417002564	Walker A/P-loop; other site
517417002565	ATP binding site [chemical binding]; other site
517417002566	Q-loop/lid; other site
517417002567	ABC transporter signature motif; other site
517417002568	Walker B; other site
517417002569	D-loop; other site
517417002570	H-loop/switch region; other site
517417002571	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
517417002572	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
517417002573	HlyD family secretion protein; Region: HlyD_3; pfam13437
517417002574	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
517417002575	TPR repeat; Region: TPR_11; pfam13414
517417002576	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
517417002577	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
517417002578	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
517417002579	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
517417002580	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
517417002581	cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059
517417002582	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
517417002583	Cadherin repeat-like domain; Region: CA_like; cl15786
517417002584	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
517417002585	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
517417002586	active site
517417002587	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
517417002588	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
517417002589	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
517417002590	oligomerization interface [polypeptide binding]; other site
517417002591	active site
517417002592	metal binding site [ion binding]; metal-binding site
517417002593	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
517417002594	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
517417002595	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
517417002596	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
517417002597	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
517417002598	putative active site [active]
517417002599	catalytic triad [active]
517417002600	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
517417002601	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
517417002602	putative substrate translocation pore; other site
517417002603	Protein of unknown function (DUF1847); Region: DUF1847; pfam08901
517417002604	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
517417002605	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
517417002606	Coenzyme A binding pocket [chemical binding]; other site
517417002607	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
517417002608	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517417002609	S-adenosylmethionine binding site [chemical binding]; other site
517417002610	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
517417002611	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
517417002612	dimer interface [polypeptide binding]; other site
517417002613	active site residues [active]
517417002614	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
517417002615	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
517417002616	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
517417002617	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
517417002618	Ligand Binding Site [chemical binding]; other site
517417002619	membrane ATPase/protein kinase; Provisional; Region: PRK09435
517417002620	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
517417002621	Walker A; other site
517417002622	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
517417002623	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
517417002624	active site
517417002625	substrate binding site [chemical binding]; other site
517417002626	coenzyme B12 binding site [chemical binding]; other site
517417002627	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
517417002628	B12 binding site [chemical binding]; other site
517417002629	cobalt ligand [ion binding]; other site
517417002630	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
517417002631	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
517417002632	heterodimer interface [polypeptide binding]; other site
517417002633	substrate interaction site [chemical binding]; other site
517417002634	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
517417002635	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
517417002636	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
517417002637	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
517417002638	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
517417002639	dimer interface [polypeptide binding]; other site
517417002640	substrate binding site [chemical binding]; other site
517417002641	metal binding site [ion binding]; metal-binding site
517417002642	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
517417002643	Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967
517417002644	acyl-activating enzyme (AAE) consensus motif; other site
517417002645	putative AMP binding site [chemical binding]; other site
517417002646	putative active site [active]
517417002647	putative CoA binding site [chemical binding]; other site
517417002648	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
517417002649	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517417002650	S-adenosylmethionine binding site [chemical binding]; other site
517417002651	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
517417002652	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
517417002653	PYR/PP interface [polypeptide binding]; other site
517417002654	dimer interface [polypeptide binding]; other site
517417002655	TPP binding site [chemical binding]; other site
517417002656	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
517417002657	hypothetical protein; Provisional; Region: PRK14621
517417002658	recombination protein RecR; Reviewed; Region: recR; PRK00076
517417002659	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
517417002660	RecR protein; Region: RecR; pfam02132
517417002661	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
517417002662	putative active site [active]
517417002663	putative metal-binding site [ion binding]; other site
517417002664	tetramer interface [polypeptide binding]; other site
517417002665	phytoene desaturase; Region: phytoene_desat; TIGR02731
517417002666	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
517417002667	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
517417002668	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
517417002669	Walker A/P-loop; other site
517417002670	ATP binding site [chemical binding]; other site
517417002671	Q-loop/lid; other site
517417002672	ABC transporter signature motif; other site
517417002673	Walker B; other site
517417002674	D-loop; other site
517417002675	H-loop/switch region; other site
517417002676	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
517417002677	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
517417002678	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
517417002679	Walker A/P-loop; other site
517417002680	ATP binding site [chemical binding]; other site
517417002681	Q-loop/lid; other site
517417002682	ABC transporter signature motif; other site
517417002683	Walker B; other site
517417002684	D-loop; other site
517417002685	H-loop/switch region; other site
517417002686	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
517417002687	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
517417002688	HlyD family secretion protein; Region: HlyD_3; pfam13437
517417002689	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
517417002690	Predicted permeases [General function prediction only]; Region: COG0701
517417002691	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
517417002692	putative FMN binding site [chemical binding]; other site
517417002693	NADPH bind site [chemical binding]; other site
517417002694	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
517417002695	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
517417002696	metal-binding site [ion binding]
517417002697	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
517417002698	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
517417002699	motif II; other site
517417002700	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
517417002701	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
517417002702	G1 box; other site
517417002703	putative GEF interaction site [polypeptide binding]; other site
517417002704	GTP/Mg2+ binding site [chemical binding]; other site
517417002705	Switch I region; other site
517417002706	G2 box; other site
517417002707	G3 box; other site
517417002708	Switch II region; other site
517417002709	G4 box; other site
517417002710	G5 box; other site
517417002711	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
517417002712	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
517417002713	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
517417002714	Coenzyme A binding pocket [chemical binding]; other site
517417002715	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
517417002716	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
517417002717	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
517417002718	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
517417002719	dimer interface [polypeptide binding]; other site
517417002720	substrate binding site [chemical binding]; other site
517417002721	metal binding sites [ion binding]; metal-binding site
517417002722	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
517417002723	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
517417002724	NeuB family; Region: NeuB; pfam03102
517417002725	heat shock protein 90; Provisional; Region: PRK05218
517417002726	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517417002727	ATP binding site [chemical binding]; other site
517417002728	Mg2+ binding site [ion binding]; other site
517417002729	G-X-G motif; other site
517417002730	Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044
517417002731	diiron binding motif [ion binding]; other site
517417002732	CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431
517417002733	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
517417002734	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
517417002735	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
517417002736	AAA domain; Region: AAA_33; pfam13671
517417002737	active site
517417002738	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
517417002739	Ligand Binding Site [chemical binding]; other site
517417002740	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
517417002741	Fumarase C-terminus; Region: Fumerase_C; pfam05683
517417002742	Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016
517417002743	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
517417002744	active site
517417002745	catalytic residues [active]
517417002746	metal binding site [ion binding]; metal-binding site
517417002747	homodimer binding site [polypeptide binding]; other site
517417002748	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
517417002749	carboxyltransferase (CT) interaction site; other site
517417002750	biotinylation site [posttranslational modification]; other site
517417002751	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517417002752	Radical SAM superfamily; Region: Radical_SAM; pfam04055
517417002753	FeS/SAM binding site; other site
517417002754	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
517417002755	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304
517417002756	Protein of unknown function (DUF497); Region: DUF497; cl01108
517417002757	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
517417002758	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
517417002759	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
517417002760	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
517417002761	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
517417002762	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
517417002763	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
517417002764	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
517417002765	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
517417002766	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
517417002767	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
517417002768	putative ADP-binding pocket [chemical binding]; other site
517417002769	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
517417002770	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
517417002771	active site
517417002772	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
517417002773	generic binding surface II; other site
517417002774	generic binding surface I; other site
517417002775	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
517417002776	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
517417002777	catalytic residues [active]
517417002778	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
517417002779	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
517417002780	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
517417002781	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
517417002782	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
517417002783	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
517417002784	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
517417002785	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
517417002786	NAD(P) binding site [chemical binding]; other site
517417002787	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
517417002788	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
517417002789	active site
517417002790	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
517417002791	protoheme IX farnesyltransferase; Region: cyoE_ctaB; TIGR01473
517417002792	UbiA prenyltransferase family; Region: UbiA; pfam01040
517417002793	cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525
517417002794	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
517417002795	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
517417002796	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
517417002797	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
517417002798	D-pathway; other site
517417002799	Putative ubiquinol binding site [chemical binding]; other site
517417002800	Low-spin heme (heme b) binding site [chemical binding]; other site
517417002801	Putative water exit pathway; other site
517417002802	Binuclear center (heme o3/CuB) [ion binding]; other site
517417002803	K-pathway; other site
517417002804	Putative proton exit pathway; other site
517417002805	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
517417002806	Subunit I/III interface [polypeptide binding]; other site
517417002807	Subunit III/IV interface [polypeptide binding]; other site
517417002808	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
517417002809	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
517417002810	Ligand Binding Site [chemical binding]; other site
517417002811	Predicted membrane protein [Function unknown]; Region: COG2855
517417002812	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682
517417002813	nudix motif; other site
517417002814	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
517417002815	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517417002816	Walker B motif; other site
517417002817	arginine finger; other site
517417002818	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
517417002819	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
517417002820	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
517417002821	PAAR motif; Region: PAAR_motif; pfam05488
517417002822	Phage protein D [General function prediction only]; Region: COG3500
517417002823	Rhs element Vgr protein; Region: vgr_GE; TIGR01646
517417002824	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
517417002825	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
517417002826	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
517417002827	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
517417002828	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
517417002829	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
517417002830	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
517417002831	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
517417002832	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
517417002833	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
517417002834	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
517417002835	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
517417002836	putative active site [active]
517417002837	putative metal binding site [ion binding]; other site
517417002838	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
517417002839	putative active site [active]
517417002840	putative metal binding site [ion binding]; other site
517417002841	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
517417002842	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
517417002843	P-loop; other site
517417002844	Magnesium ion binding site [ion binding]; other site
517417002845	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
517417002846	Magnesium ion binding site [ion binding]; other site
517417002847	CHAD domain; Region: CHAD; pfam05235
517417002848	E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387
517417002849	polyphosphate kinase; Provisional; Region: PRK05443
517417002850	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
517417002851	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
517417002852	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
517417002853	putative domain interface [polypeptide binding]; other site
517417002854	putative active site [active]
517417002855	catalytic site [active]
517417002856	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
517417002857	putative domain interface [polypeptide binding]; other site
517417002858	putative active site [active]
517417002859	catalytic site [active]
517417002860	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
517417002861	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
517417002862	motif II; other site
517417002863	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
517417002864	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
517417002865	putative acyl-acceptor binding pocket; other site
517417002866	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
517417002867	Coenzyme A binding pocket [chemical binding]; other site
517417002868	PBP superfamily domain; Region: PBP_like_2; cl17296
517417002869	phosphate binding protein; Region: ptsS_2; TIGR02136
517417002870	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
517417002871	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
517417002872	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
517417002873	dimer interface [polypeptide binding]; other site
517417002874	conserved gate region; other site
517417002875	putative PBP binding loops; other site
517417002876	ABC-ATPase subunit interface; other site
517417002877	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
517417002878	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
517417002879	dimer interface [polypeptide binding]; other site
517417002880	conserved gate region; other site
517417002881	putative PBP binding loops; other site
517417002882	ABC-ATPase subunit interface; other site
517417002883	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14275
517417002884	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
517417002885	Walker A/P-loop; other site
517417002886	ATP binding site [chemical binding]; other site
517417002887	Q-loop/lid; other site
517417002888	ABC transporter signature motif; other site
517417002889	Walker B; other site
517417002890	D-loop; other site
517417002891	H-loop/switch region; other site
517417002892	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
517417002893	PhoU domain; Region: PhoU; pfam01895
517417002894	PhoU domain; Region: PhoU; pfam01895
517417002895	Protein of unknown function (DUF3124); Region: DUF3124; pfam11322
517417002896	PhoU domain; Region: PhoU; pfam01895
517417002897	PhoU domain; Region: PhoU; pfam01895
517417002898	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
517417002899	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
517417002900	HlyD family secretion protein; Region: HlyD_3; pfam13437
517417002901	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
517417002902	DoxX-like family; Region: DoxX_3; pfam13781
517417002903	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
517417002904	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
517417002905	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
517417002906	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
517417002907	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
517417002908	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
517417002909	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
517417002910	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
517417002911	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
517417002912	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
517417002913	active site
517417002914	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
517417002915	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
517417002916	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
517417002917	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
517417002918	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
517417002919	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
517417002920	motif II; other site
517417002921	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
517417002922	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
517417002923	FAD binding domain; Region: FAD_binding_4; pfam01565
517417002924	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
517417002925	Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627
517417002926	putative heme binding site [chemical binding]; other site
517417002927	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
517417002928	TPR repeat; Region: TPR_11; pfam13414
517417002929	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517417002930	TPR motif; other site
517417002931	binding surface
517417002932	Tubulin like; Region: Tubulin_2; pfam13809
517417002933	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
517417002934	cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345
517417002935	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
517417002936	FAD binding pocket [chemical binding]; other site
517417002937	FAD binding motif [chemical binding]; other site
517417002938	phosphate binding motif [ion binding]; other site
517417002939	beta-alpha-beta structure motif; other site
517417002940	NAD binding pocket [chemical binding]; other site
517417002941	Iron coordination center [ion binding]; other site
517417002942	anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055
517417002943	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
517417002944	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
517417002945	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
517417002946	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
517417002947	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
517417002948	Cysteine-rich domain; Region: CCG; pfam02754
517417002949	Cysteine-rich domain; Region: CCG; pfam02754
517417002950	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
517417002951	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
517417002952	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
517417002953	aspartate aminotransferase; Provisional; Region: PRK08636
517417002954	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
517417002955	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517417002956	homodimer interface [polypeptide binding]; other site
517417002957	catalytic residue [active]
517417002958	Uncharacterized conserved protein [Function unknown]; Region: COG0062
517417002959	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
517417002960	putative substrate binding site [chemical binding]; other site
517417002961	putative ATP binding site [chemical binding]; other site
517417002962	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
517417002963	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
517417002964	dimerization interface [polypeptide binding]; other site
517417002965	ATP binding site [chemical binding]; other site
517417002966	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
517417002967	dimerization interface [polypeptide binding]; other site
517417002968	ATP binding site [chemical binding]; other site
517417002969	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12900
517417002970	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
517417002971	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
517417002972	nucleotide binding region [chemical binding]; other site
517417002973	ATP-binding site [chemical binding]; other site
517417002974	SEC-C motif; Region: SEC-C; pfam02810
517417002975	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
517417002976	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
517417002977	NAD(P) binding site [chemical binding]; other site
517417002978	putative active site [active]
517417002979	8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934
517417002980	8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588
517417002981	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
517417002982	minor groove reading motif; other site
517417002983	helix-hairpin-helix signature motif; other site
517417002984	substrate binding pocket [chemical binding]; other site
517417002985	active site
517417002986	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
517417002987	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
517417002988	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
517417002989	ATP binding site [chemical binding]; other site
517417002990	putative Mg++ binding site [ion binding]; other site
517417002991	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
517417002992	HsdM N-terminal domain; Region: HsdM_N; pfam12161
517417002993	Methyltransferase domain; Region: Methyltransf_26; pfam13659
517417002994	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
517417002995	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
517417002996	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
517417002997	AAA ATPase domain; Region: AAA_15; pfam13175
517417002998	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
517417002999	Walker A/P-loop; other site
517417003000	ATP binding site [chemical binding]; other site
517417003001	Ceramidase; Region: Ceramidase; pfam05875
517417003002	CAAX protease self-immunity; Region: Abi; pfam02517
517417003003	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
517417003004	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
517417003005	PhnA protein; Region: PhnA; pfam03831
517417003006	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
517417003007	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
517417003008	ligand binding site [chemical binding]; other site
517417003009	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
517417003010	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
517417003011	putative NADP binding site [chemical binding]; other site
517417003012	putative substrate binding site [chemical binding]; other site
517417003013	active site
517417003014	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
517417003015	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
517417003016	ligand binding site [chemical binding]; other site
517417003017	flexible hinge region; other site
517417003018	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
517417003019	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
517417003020	metal binding triad; other site
517417003021	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
517417003022	active site
517417003023	catalytic site [active]
517417003024	substrate binding site [chemical binding]; other site
517417003025	Methyltransferase domain; Region: Methyltransf_23; pfam13489
517417003026	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517417003027	S-adenosylmethionine binding site [chemical binding]; other site
517417003028	dihydroorotase; Validated; Region: pyrC; PRK09357
517417003029	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
517417003030	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
517417003031	active site
517417003032	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
517417003033	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
517417003034	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
517417003035	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
517417003036	polyphosphate kinase; Provisional; Region: PRK05443
517417003037	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
517417003038	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
517417003039	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
517417003040	putative domain interface [polypeptide binding]; other site
517417003041	putative active site [active]
517417003042	catalytic site [active]
517417003043	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
517417003044	putative domain interface [polypeptide binding]; other site
517417003045	putative active site [active]
517417003046	catalytic site [active]
517417003047	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
517417003048	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
517417003049	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
517417003050	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
517417003051	metal binding site [ion binding]; metal-binding site
517417003052	dimer interface [polypeptide binding]; other site
517417003053	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
517417003054	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
517417003055	intersubunit interface [polypeptide binding]; other site
517417003056	active site
517417003057	zinc binding site [ion binding]; other site
517417003058	Na+ binding site [ion binding]; other site
517417003059	carboxy-terminal protease; Provisional; Region: PRK11186
517417003060	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
517417003061	protein binding site [polypeptide binding]; other site
517417003062	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
517417003063	Catalytic dyad [active]
517417003064	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
517417003065	argininosuccinate lyase; Provisional; Region: PRK00855
517417003066	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
517417003067	active sites [active]
517417003068	tetramer interface [polypeptide binding]; other site
517417003069	argininosuccinate synthase; Provisional; Region: PRK13820
517417003070	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
517417003071	ANP binding site [chemical binding]; other site
517417003072	Substrate Binding Site II [chemical binding]; other site
517417003073	Substrate Binding Site I [chemical binding]; other site
517417003074	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
517417003075	arginine repressor; Provisional; Region: PRK04280
517417003076	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
517417003077	ornithine carbamoyltransferase; Provisional; Region: PRK00779
517417003078	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
517417003079	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
517417003080	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
517417003081	feedback inhibition sensing region; other site
517417003082	homohexameric interface [polypeptide binding]; other site
517417003083	nucleotide binding site [chemical binding]; other site
517417003084	N-acetyl-L-glutamate binding site [chemical binding]; other site
517417003085	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
517417003086	heterotetramer interface [polypeptide binding]; other site
517417003087	active site pocket [active]
517417003088	cleavage site
517417003089	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
517417003090	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
517417003091	PBP superfamily domain; Region: PBP_like_2; pfam12849
517417003092	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
517417003093	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
517417003094	metal binding site [ion binding]; metal-binding site
517417003095	active site
517417003096	I-site; other site
517417003097	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
517417003098	Mechanosensitive ion channel; Region: MS_channel; pfam00924
517417003099	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
517417003100	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
517417003101	FtsX-like permease family; Region: FtsX; pfam02687
517417003102	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
517417003103	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
517417003104	Rubredoxin; Region: Rubredoxin; pfam00301
517417003105	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
517417003106	iron binding site [ion binding]; other site
517417003107	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
517417003108	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
517417003109	Coenzyme A binding pocket [chemical binding]; other site
517417003110	Rubredoxin [Energy production and conversion]; Region: COG1773
517417003111	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
517417003112	iron binding site [ion binding]; other site
517417003113	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
517417003114	Predicted membrane protein [Function unknown]; Region: COG2119
517417003115	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
517417003116	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
517417003117	Domain of unknown function DUF87; Region: DUF87; pfam01935
517417003118	AAA-like domain; Region: AAA_10; pfam12846
517417003119	Cdc37 N terminal kinase binding; Region: CDC37_N; cl03951
517417003120	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
517417003121	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
517417003122	Walker A/P-loop; other site
517417003123	ATP binding site [chemical binding]; other site
517417003124	Q-loop/lid; other site
517417003125	ABC transporter signature motif; other site
517417003126	Walker B; other site
517417003127	D-loop; other site
517417003128	H-loop/switch region; other site
517417003129	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
517417003130	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
517417003131	Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045
517417003132	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
517417003133	CoA binding domain; Region: CoA_binding; smart00881
517417003134	ATP citrate (pro-S)-lyase; Region: PLN02522
517417003135	CoA-ligase; Region: Ligase_CoA; pfam00549
517417003136	Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100
517417003137	active site
517417003138	oxalacetate binding site [chemical binding]; other site
517417003139	citrylCoA binding site [chemical binding]; other site
517417003140	coenzyme A binding site [chemical binding]; other site
517417003141	catalytic triad [active]
517417003142	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
517417003143	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
517417003144	phosphate acetyltransferase; Provisional; Region: PRK11890
517417003145	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
517417003146	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
517417003147	putative dimerization interface [polypeptide binding]; other site
517417003148	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
517417003149	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
517417003150	metal binding site [ion binding]; metal-binding site
517417003151	dimer interface [polypeptide binding]; other site
517417003152	cyclase homology domain; Region: CHD; cd07302
517417003153	nucleotidyl binding site; other site
517417003154	metal binding site [ion binding]; metal-binding site
517417003155	dimer interface [polypeptide binding]; other site
517417003156	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
517417003157	ATP-grasp domain; Region: ATP-grasp; pfam02222
517417003158	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866
517417003159	putative hydrophobic ligand binding site [chemical binding]; other site
517417003160	Protein of unknown function (DUF1634); Region: DUF1634; pfam07843
517417003161	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
517417003162	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
517417003163	Coenzyme A binding pocket [chemical binding]; other site
517417003164	mechanosensitive channel MscS; Provisional; Region: PRK10334
517417003165	Mechanosensitive ion channel; Region: MS_channel; pfam00924
517417003166	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
517417003167	NADH(P)-binding; Region: NAD_binding_10; pfam13460
517417003168	NAD(P) binding site [chemical binding]; other site
517417003169	putative active site [active]
517417003170	TIGR02453 family protein; Region: TIGR02453
517417003171	YXWGXW repeat (2 copies); Region: YXWGXW; pfam12779
517417003172	yecA family protein; Region: ygfB_yecA; TIGR02292
517417003173	HTH domain; Region: HTH_11; cl17392
517417003174	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
517417003175	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
517417003176	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
517417003177	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
517417003178	AAA domain; Region: AAA_30; pfam13604
517417003179	Family description; Region: UvrD_C_2; pfam13538
517417003180	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
517417003181	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
517417003182	active site
517417003183	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
517417003184	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
517417003185	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
517417003186	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
517417003187	catalytic residues [active]
517417003188	Domain of unknown function (DUF4266); Region: DUF4266; pfam14086
517417003189	Protein of unknown function (DUF3570); Region: DUF3570; pfam12094
517417003190	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
517417003191	ApbE family; Region: ApbE; pfam02424
517417003192	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
517417003193	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
517417003194	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
517417003195	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
517417003196	DsbD alpha interface [polypeptide binding]; other site
517417003197	catalytic residues [active]
517417003198	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
517417003199	NADH(P)-binding; Region: NAD_binding_10; pfam13460
517417003200	NAD(P) binding site [chemical binding]; other site
517417003201	putative active site [active]
517417003202	lipoyl synthase; Provisional; Region: PRK05481
517417003203	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517417003204	FeS/SAM binding site; other site
517417003205	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
517417003206	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
517417003207	Cupin domain; Region: Cupin_2; pfam07883
517417003208	multidrug resistance protein MdtN; Provisional; Region: PRK10476
517417003209	HlyD family secretion protein; Region: HlyD_3; pfam13437
517417003210	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
517417003211	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
517417003212	Walker A/P-loop; other site
517417003213	ATP binding site [chemical binding]; other site
517417003214	Q-loop/lid; other site
517417003215	ABC transporter signature motif; other site
517417003216	Walker B; other site
517417003217	D-loop; other site
517417003218	H-loop/switch region; other site
517417003219	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
517417003220	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
517417003221	Walker A/P-loop; other site
517417003222	ATP binding site [chemical binding]; other site
517417003223	Q-loop/lid; other site
517417003224	ABC transporter signature motif; other site
517417003225	Walker B; other site
517417003226	D-loop; other site
517417003227	H-loop/switch region; other site
517417003228	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
517417003229	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
517417003230	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
517417003231	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
517417003232	Restriction endonuclease; Region: Mrr_cat; pfam04471
517417003233	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
517417003234	octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315
517417003235	Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783
517417003236	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
517417003237	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
517417003238	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
517417003239	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517417003240	NmrA-like family; Region: NmrA; pfam05368
517417003241	NAD(P) binding site [chemical binding]; other site
517417003242	active site
517417003243	NAD-dependent deacetylase; Provisional; Region: PRK00481
517417003244	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
517417003245	NAD+ binding site [chemical binding]; other site
517417003246	substrate binding site [chemical binding]; other site
517417003247	Zn binding site [ion binding]; other site
517417003248	DsrE/DsrF-like family; Region: DrsE; pfam02635
517417003249	Ion transport protein; Region: Ion_trans; pfam00520
517417003250	Ion channel; Region: Ion_trans_2; pfam07885
517417003251	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
517417003252	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
517417003253	dimer interface [polypeptide binding]; other site
517417003254	active site
517417003255	metal binding site [ion binding]; metal-binding site
517417003256	alternate F1F0 ATPase, F1 subunit beta; Region: alt_F1F0_F1_bet; TIGR03305
517417003257	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
517417003258	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
517417003259	alpha subunit interaction interface [polypeptide binding]; other site
517417003260	Walker A motif; other site
517417003261	ATP binding site [chemical binding]; other site
517417003262	Walker B motif; other site
517417003263	inhibitor binding site; inhibition site
517417003264	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
517417003265	F0F1 ATP synthase subunit epsilon; Validated; Region: PRK06228
517417003266	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
517417003267	gamma subunit interface [polypeptide binding]; other site
517417003268	epsilon subunit interface [polypeptide binding]; other site
517417003269	LBP interface [polypeptide binding]; other site
517417003270	F0F1-ATPase subunit, putative; Region: ATPase_gene1; TIGR02230
517417003271	F1/F0 ATPase, Methanosarcina type, subunit 2; Region: F1F0_chp_2; TIGR03165
517417003272	alternate F1F0 ATPase, F0 subunit A; Region: altF1_A; TIGR03306
517417003273	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
517417003274	alternate F1F0 ATPase, F0 subunit C; Region: alt_F1F0_F0_C; TIGR03322
517417003275	alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321
517417003276	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
517417003277	alternate F1F0 ATPase, F1 subunit alpha; Region: alt_F1F0_F1_al; TIGR03324
517417003278	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
517417003279	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
517417003280	Walker A motif; other site
517417003281	ATP binding site [chemical binding]; other site
517417003282	Walker B motif; other site
517417003283	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
517417003284	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
517417003285	core domain interface [polypeptide binding]; other site
517417003286	delta subunit interface [polypeptide binding]; other site
517417003287	epsilon subunit interface [polypeptide binding]; other site
517417003288	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
517417003289	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
517417003290	ATP binding site [chemical binding]; other site
517417003291	Mg++ binding site [ion binding]; other site
517417003292	motif III; other site
517417003293	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
517417003294	nucleotide binding region [chemical binding]; other site
517417003295	ATP-binding site [chemical binding]; other site
517417003296	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
517417003297	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
517417003298	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
517417003299	catalytic residues [active]
517417003300	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
517417003301	Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411
517417003302	active site
517417003303	metal binding site [ion binding]; metal-binding site
517417003304	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
517417003305	Cytochrome c [Energy production and conversion]; Region: COG3258
517417003306	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
517417003307	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
517417003308	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
517417003309	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
517417003310	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
517417003311	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
517417003312	Methyltransferase domain; Region: Methyltransf_12; pfam08242
517417003313	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
517417003314	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
517417003315	active site
517417003316	FMN binding site [chemical binding]; other site
517417003317	substrate binding site [chemical binding]; other site
517417003318	putative catalytic residue [active]
517417003319	Protein of unknown function (DUF3683); Region: DUF3683; pfam12447
517417003320	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
517417003321	FAD binding domain; Region: FAD_binding_4; pfam01565
517417003322	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
517417003323	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
517417003324	Domain of unknown function (DUF3400); Region: DUF3400; pfam11880
517417003325	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
517417003326	classical (c) SDRs; Region: SDR_c; cd05233
517417003327	NAD(P) binding site [chemical binding]; other site
517417003328	active site
517417003329	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
517417003330	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
517417003331	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
517417003332	Ligand Binding Site [chemical binding]; other site
517417003333	NlpC/P60 family; Region: NLPC_P60; pfam00877
517417003334	Uncharacterized conserved protein [Function unknown]; Region: COG1434
517417003335	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
517417003336	putative active site [active]
517417003337	exonuclease SbcC; Region: sbcc; TIGR00618
517417003338	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
517417003339	Walker A/P-loop; other site
517417003340	ATP binding site [chemical binding]; other site
517417003341	Q-loop/lid; other site
517417003342	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
517417003343	ABC transporter signature motif; other site
517417003344	Walker B; other site
517417003345	D-loop; other site
517417003346	H-loop/switch region; other site
517417003347	exonuclease subunit SbcD; Provisional; Region: PRK10966
517417003348	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
517417003349	active site
517417003350	metal binding site [ion binding]; metal-binding site
517417003351	DNA binding site [nucleotide binding]
517417003352	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
517417003353	RmuC family; Region: RmuC; pfam02646
517417003354	TIR domain; Region: TIR_2; pfam13676
517417003355	AAA domain; Region: AAA_22; pfam13401
517417003356	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517417003357	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517417003358	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517417003359	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517417003360	binding surface
517417003361	TPR motif; other site
517417003362	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517417003363	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
517417003364	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
517417003365	Nitroreductase family. Members of this family utilize FMN as a cofactor. This family is involved in the reduction of flavin or nitroaromatic compounds by using NAD(P)H as electron donor in a obligatory two-electron transfer. Nitrogenase is homodimer; Region: NADH_nitroreductase; cd02143
517417003366	putative FMN binding site [chemical binding]; other site
517417003367	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
517417003368	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
517417003369	inhibitor-cofactor binding pocket; inhibition site
517417003370	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517417003371	catalytic residue [active]
517417003372	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
517417003373	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
517417003374	active site
517417003375	NAD binding site [chemical binding]; other site
517417003376	metal binding site [ion binding]; metal-binding site
517417003377	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
517417003378	ligand binding site; other site
517417003379	tetramer interface; other site
517417003380	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
517417003381	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
517417003382	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
517417003383	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
517417003384	acyl-activating enzyme (AAE) consensus motif; other site
517417003385	putative AMP binding site [chemical binding]; other site
517417003386	putative active site [active]
517417003387	putative CoA binding site [chemical binding]; other site
517417003388	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
517417003389	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
517417003390	endonuclease III; Region: ENDO3c; smart00478
517417003391	minor groove reading motif; other site
517417003392	helix-hairpin-helix signature motif; other site
517417003393	substrate binding pocket [chemical binding]; other site
517417003394	active site
517417003395	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
517417003396	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
517417003397	16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273
517417003398	RimM N-terminal domain; Region: RimM; pfam01782
517417003399	PRC-barrel domain; Region: PRC; pfam05239
517417003400	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
517417003401	signal recognition particle protein; Provisional; Region: PRK10867
517417003402	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
517417003403	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
517417003404	P loop; other site
517417003405	GTP binding site [chemical binding]; other site
517417003406	Signal peptide binding domain; Region: SRP_SPB; pfam02978
517417003407	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
517417003408	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
517417003409	putative ribose interaction site [chemical binding]; other site
517417003410	putative ADP binding site [chemical binding]; other site
517417003411	Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876
517417003412	putative lipid binding site [chemical binding]; other site
517417003413	Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876
517417003414	putative lipid binding site [chemical binding]; other site
517417003415	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
517417003416	C-terminal peptidase (prc); Region: prc; TIGR00225
517417003417	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
517417003418	protein binding site [polypeptide binding]; other site
517417003419	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
517417003420	Catalytic dyad [active]
517417003421	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
517417003422	homotrimer interaction site [polypeptide binding]; other site
517417003423	putative active site [active]
517417003424	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
517417003425	active site
517417003426	thiamine phosphate binding site [chemical binding]; other site
517417003427	pyrophosphate binding site [ion binding]; other site
517417003428	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
517417003429	thiamine phosphate binding site [chemical binding]; other site
517417003430	active site
517417003431	pyrophosphate binding site [ion binding]; other site
517417003432	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
517417003433	dimer interface [polypeptide binding]; other site
517417003434	substrate binding site [chemical binding]; other site
517417003435	ATP binding site [chemical binding]; other site
517417003436	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
517417003437	PGAP1-like protein; Region: PGAP1; pfam07819
517417003438	multifunctional aminopeptidase A; Provisional; Region: PRK00913
517417003439	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
517417003440	interface (dimer of trimers) [polypeptide binding]; other site
517417003441	Substrate-binding/catalytic site; other site
517417003442	Zn-binding sites [ion binding]; other site
517417003443	DHH family; Region: DHH; pfam01368
517417003444	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
517417003445	DHHA1 domain; Region: DHHA1; pfam02272
517417003446	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
517417003447	Transcriptional regulators [Transcription]; Region: MarR; COG1846
517417003448	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14456
517417003449	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517417003450	FeS/SAM binding site; other site
517417003451	adenylate kinase; Reviewed; Region: adk; PRK00279
517417003452	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
517417003453	AMP-binding site [chemical binding]; other site
517417003454	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
517417003455	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
517417003456	primosomal protein N' Region: priA; TIGR00595
517417003457	ATP binding site [chemical binding]; other site
517417003458	putative Mg++ binding site [ion binding]; other site
517417003459	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
517417003460	ATP-binding site [chemical binding]; other site
517417003461	Predicted membrane protein [Function unknown]; Region: COG2259
517417003462	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
517417003463	Dehydroquinase class II; Region: DHquinase_II; pfam01220
517417003464	trimer interface [polypeptide binding]; other site
517417003465	active site
517417003466	dimer interface [polypeptide binding]; other site
517417003467	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
517417003468	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
517417003469	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517417003470	Walker A motif; other site
517417003471	ATP binding site [chemical binding]; other site
517417003472	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
517417003473	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
517417003474	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
517417003475	active site
517417003476	HslU subunit interaction site [polypeptide binding]; other site
517417003477	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
517417003478	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
517417003479	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
517417003480	Protein of unknown function (DUF3109); Region: DUF3109; pfam11307
517417003481	DNA repair protein RadA; Provisional; Region: PRK11823
517417003482	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
517417003483	Walker A motif/ATP binding site; other site
517417003484	ATP binding site [chemical binding]; other site
517417003485	Walker B motif; other site
517417003486	Membrane protein of unknown function; Region: DUF360; pfam04020
517417003487	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202
517417003488	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
517417003489	putative NAD(P) binding site [chemical binding]; other site
517417003490	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
517417003491	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
517417003492	Walker A/P-loop; other site
517417003493	ATP binding site [chemical binding]; other site
517417003494	Q-loop/lid; other site
517417003495	ABC transporter signature motif; other site
517417003496	Walker B; other site
517417003497	D-loop; other site
517417003498	H-loop/switch region; other site
517417003499	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
517417003500	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
517417003501	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
517417003502	TM-ABC transporter signature motif; other site
517417003503	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
517417003504	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
517417003505	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517417003506	S-adenosylmethionine binding site [chemical binding]; other site
517417003507	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
517417003508	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
517417003509	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
517417003510	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
517417003511	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
517417003512	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
517417003513	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
517417003514	substrate binding pocket [chemical binding]; other site
517417003515	chain length determination region; other site
517417003516	substrate-Mg2+ binding site; other site
517417003517	catalytic residues [active]
517417003518	aspartate-rich region 1; other site
517417003519	active site lid residues [active]
517417003520	aspartate-rich region 2; other site
517417003521	Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902
517417003522	S-formylglutathione hydrolase; Region: PLN02442
517417003523	dephospho-CoA kinase; Provisional; Region: coaE; PRK14731
517417003524	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
517417003525	CoA-binding site [chemical binding]; other site
517417003526	ATP-binding [chemical binding]; other site
517417003527	Domain of unknown function (DUF4296); Region: DUF4296; pfam14129
517417003528	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
517417003529	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
517417003530	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
517417003531	Domain of unknown function (DUF4292); Region: DUF4292; pfam14125
517417003532	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
517417003533	PUA domain; Region: PUA; cl00607
517417003534	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
517417003535	putative RNA binding site [nucleotide binding]; other site
517417003536	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517417003537	S-adenosylmethionine binding site [chemical binding]; other site
517417003538	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; pfam06941
517417003539	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
517417003540	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
517417003541	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
517417003542	catalytic residues [active]
517417003543	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
517417003544	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
517417003545	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
517417003546	flavoprotein, HI0933 family; Region: TIGR00275
517417003547	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
517417003548	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
517417003549	HlyD family secretion protein; Region: HlyD_3; pfam13437
517417003550	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
517417003551	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
517417003552	FtsX-like permease family; Region: FtsX; pfam02687
517417003553	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
517417003554	FtsX-like permease family; Region: FtsX; pfam02687
517417003555	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
517417003556	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
517417003557	Walker A/P-loop; other site
517417003558	ATP binding site [chemical binding]; other site
517417003559	Q-loop/lid; other site
517417003560	ABC transporter signature motif; other site
517417003561	Walker B; other site
517417003562	D-loop; other site
517417003563	H-loop/switch region; other site
517417003564	SET domain; Region: SET; pfam00856
517417003565	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183
517417003566	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
517417003567	putative active site [active]
517417003568	metal binding site [ion binding]; metal-binding site
517417003569	Predicted DNA-binding proteins [General function prediction only]; Region: COG1342
517417003570	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
517417003571	DNA binding residues [nucleotide binding]
517417003572	OsmC-like protein; Region: OsmC; pfam02566
517417003573	cobalamin synthase; Reviewed; Region: cobS; PRK00235
517417003574	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
517417003575	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
517417003576	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
517417003577	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
517417003578	putative dimer interface [polypeptide binding]; other site
517417003579	active site pocket [active]
517417003580	putative cataytic base [active]
517417003581	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
517417003582	homotrimer interface [polypeptide binding]; other site
517417003583	Walker A motif; other site
517417003584	GTP binding site [chemical binding]; other site
517417003585	Walker B motif; other site
517417003586	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
517417003587	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
517417003588	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
517417003589	Walker A/P-loop; other site
517417003590	ATP binding site [chemical binding]; other site
517417003591	Q-loop/lid; other site
517417003592	ABC transporter signature motif; other site
517417003593	Walker B; other site
517417003594	D-loop; other site
517417003595	H-loop/switch region; other site
517417003596	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
517417003597	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
517417003598	ABC-ATPase subunit  interface; other site
517417003599	dimer interface [polypeptide binding]; other site
517417003600	putative PBP binding regions; other site
517417003601	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572
517417003602	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
517417003603	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
517417003604	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
517417003605	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517417003606	homodimer interface [polypeptide binding]; other site
517417003607	catalytic residue [active]
517417003608	cobyric acid synthase; Provisional; Region: PRK00784
517417003609	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
517417003610	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
517417003611	catalytic triad [active]
517417003612	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
517417003613	putative FMN binding site [chemical binding]; other site
517417003614	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
517417003615	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
517417003616	intersubunit interface [polypeptide binding]; other site
517417003617	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
517417003618	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
517417003619	N-terminal plug; other site
517417003620	ligand-binding site [chemical binding]; other site
517417003621	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
517417003622	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
517417003623	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
517417003624	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
517417003625	putative hydrophobic ligand binding site [chemical binding]; other site
517417003626	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
517417003627	nudix motif; other site
517417003628	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
517417003629	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
517417003630	cobalamin binding residues [chemical binding]; other site
517417003631	putative BtuC binding residues; other site
517417003632	dimer interface [polypeptide binding]; other site
517417003633	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
517417003634	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
517417003635	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
517417003636	catalytic triad [active]
517417003637	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517417003638	S-adenosylmethionine binding site [chemical binding]; other site
517417003639	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
517417003640	Prismane/CO dehydrogenase family; Region: Prismane; pfam03063
517417003641	ACS interaction site; other site
517417003642	CODH interaction site; other site
517417003643	metal cluster binding site [ion binding]; other site
517417003644	Cytochrome c; Region: Cytochrom_C; pfam00034
517417003645	Cytochrome c; Region: Cytochrom_C; pfam00034
517417003646	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
517417003647	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
517417003648	Walker A/P-loop; other site
517417003649	ATP binding site [chemical binding]; other site
517417003650	Q-loop/lid; other site
517417003651	ABC transporter signature motif; other site
517417003652	Walker B; other site
517417003653	D-loop; other site
517417003654	H-loop/switch region; other site
517417003655	glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493
517417003656	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
517417003657	Walker A/P-loop; other site
517417003658	ATP binding site [chemical binding]; other site
517417003659	Q-loop/lid; other site
517417003660	ABC transporter signature motif; other site
517417003661	Walker B; other site
517417003662	D-loop; other site
517417003663	H-loop/switch region; other site
517417003664	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
517417003665	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
517417003666	dimer interface [polypeptide binding]; other site
517417003667	conserved gate region; other site
517417003668	putative PBP binding loops; other site
517417003669	ABC-ATPase subunit interface; other site
517417003670	NMT1-like family; Region: NMT1_2; pfam13379
517417003671	NMT1/THI5 like; Region: NMT1; pfam09084
517417003672	CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640
517417003673	The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
517417003674	P-loop; other site
517417003675	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
517417003676	Predicted ATPase [General function prediction only]; Region: COG3911
517417003677	AAA domain; Region: AAA_28; pfam13521
517417003678	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
517417003679	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
517417003680	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
517417003681	Repair protein; Region: Repair_PSII; pfam04536
517417003682	Repair protein; Region: Repair_PSII; cl01535
517417003683	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
517417003684	active site
517417003685	catalytic site [active]
517417003686	substrate binding site [chemical binding]; other site
517417003687	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
517417003688	Eukaryotic phosphomannomutase; Region: PMM; cl17107
517417003689	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
517417003690	motif II; other site
517417003691	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
517417003692	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
517417003693	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
517417003694	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
517417003695	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
517417003696	dimerization interface [polypeptide binding]; other site
517417003697	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517417003698	dimer interface [polypeptide binding]; other site
517417003699	phosphorylation site [posttranslational modification]
517417003700	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517417003701	ATP binding site [chemical binding]; other site
517417003702	Mg2+ binding site [ion binding]; other site
517417003703	G-X-G motif; other site
517417003704	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
517417003705	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517417003706	active site
517417003707	phosphorylation site [posttranslational modification]
517417003708	intermolecular recognition site; other site
517417003709	dimerization interface [polypeptide binding]; other site
517417003710	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
517417003711	DNA binding site [nucleotide binding]
517417003712	Domain of unknown function (DUF4405); Region: DUF4405; pfam14358
517417003713	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
517417003714	Protein of unknown function (DUF3999); Region: DUF3999; pfam13163
517417003715	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
517417003716	Protein of unknown function (DUF1129); Region: DUF1129; cl11555
517417003717	Major Facilitator Superfamily; Region: MFS_1; pfam07690
517417003718	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
517417003719	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
517417003720	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
517417003721	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
517417003722	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
517417003723	active site
517417003724	NTP binding site [chemical binding]; other site
517417003725	metal binding triad [ion binding]; metal-binding site
517417003726	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
517417003727	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
517417003728	Zn2+ binding site [ion binding]; other site
517417003729	Mg2+ binding site [ion binding]; other site
517417003730	adenylosuccinate lyase; Provisional; Region: PRK07492
517417003731	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
517417003732	tetramer interface [polypeptide binding]; other site
517417003733	active site
517417003734	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
517417003735	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
517417003736	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
517417003737	active site
517417003738	dimer interface [polypeptide binding]; other site
517417003739	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
517417003740	dimer interface [polypeptide binding]; other site
517417003741	active site
517417003742	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
517417003743	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
517417003744	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
517417003745	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
517417003746	Nitrogen regulatory protein P-II; Region: P-II; smart00938
517417003747	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
517417003748	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
517417003749	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
517417003750	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
517417003751	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
517417003752	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
517417003753	P loop; other site
517417003754	Nucleotide binding site [chemical binding]; other site
517417003755	DTAP/Switch II; other site
517417003756	Switch I; other site
517417003757	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
517417003758	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
517417003759	N-acetyl-D-glucosamine binding site [chemical binding]; other site
517417003760	catalytic residue [active]
517417003761	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
517417003762	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
517417003763	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
517417003764	dimerization interface 3.5A [polypeptide binding]; other site
517417003765	active site
517417003766	Alpha amylase catalytic domain found in maltosyltransferase; Region: AmyAc_MTase_N; cd11335
517417003767	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
517417003768	homodimer interface [polypeptide binding]; other site
517417003769	active site
517417003770	catalytic site [active]
517417003771	maltose binding site 2 [chemical binding]; other site
517417003772	Ribokinase-like subgroup C.  Found only in bacteria, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_C; cd01946
517417003773	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
517417003774	substrate binding site [chemical binding]; other site
517417003775	ATP binding site [chemical binding]; other site
517417003776	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
517417003777	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477
517417003778	Na binding site [ion binding]; other site
517417003779	Maf-like protein; Region: Maf; pfam02545
517417003780	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
517417003781	active site
517417003782	dimer interface [polypeptide binding]; other site
517417003783	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
517417003784	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
517417003785	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
517417003786	anti sigma factor interaction site; other site
517417003787	regulatory phosphorylation site [posttranslational modification]; other site
517417003788	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
517417003789	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517417003790	S-adenosylmethionine binding site [chemical binding]; other site
517417003791	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
517417003792	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
517417003793	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
517417003794	active site
517417003795	HIGH motif; other site
517417003796	KMSKS motif; other site
517417003797	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
517417003798	tRNA binding surface [nucleotide binding]; other site
517417003799	anticodon binding site; other site
517417003800	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
517417003801	dimer interface [polypeptide binding]; other site
517417003802	putative tRNA-binding site [nucleotide binding]; other site
517417003803	PSP1 C-terminal conserved region; Region: PSP1; pfam04468
517417003804	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
517417003805	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551
517417003806	putative acyl-acceptor binding pocket; other site
517417003807	aspartate aminotransferase; Provisional; Region: PRK05764
517417003808	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
517417003809	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517417003810	homodimer interface [polypeptide binding]; other site
517417003811	catalytic residue [active]
517417003812	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
517417003813	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
517417003814	active site
517417003815	(T/H)XGH motif; other site
517417003816	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
517417003817	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517417003818	S-adenosylmethionine binding site [chemical binding]; other site
517417003819	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
517417003820	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
517417003821	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
517417003822	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
517417003823	ATP binding site [chemical binding]; other site
517417003824	active site
517417003825	substrate binding site [chemical binding]; other site
517417003826	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
517417003827	Sel1-like repeats; Region: SEL1; smart00671
517417003828	Sel1-like repeats; Region: SEL1; smart00671
517417003829	Sel1-like repeats; Region: SEL1; smart00671
517417003830	Sel1-like repeats; Region: SEL1; smart00671
517417003831	Sel1-like repeats; Region: SEL1; smart00671
517417003832	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
517417003833	putative catalytic site [active]
517417003834	putative metal binding site [ion binding]; other site
517417003835	putative phosphate binding site [ion binding]; other site
517417003836	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
517417003837	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
517417003838	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
517417003839	putative active site [active]
517417003840	catalytic residue [active]
517417003841	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
517417003842	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
517417003843	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
517417003844	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
517417003845	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
517417003846	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517417003847	homodimer interface [polypeptide binding]; other site
517417003848	catalytic residue [active]
517417003849	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
517417003850	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
517417003851	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
517417003852	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
517417003853	NADP binding site [chemical binding]; other site
517417003854	homopentamer interface [polypeptide binding]; other site
517417003855	substrate binding site [chemical binding]; other site
517417003856	active site
517417003857	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
517417003858	PhoH-like protein; Region: PhoH; pfam02562
517417003859	benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224
517417003860	hypothetical protein; Provisional; Region: PRK13795
517417003861	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
517417003862	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
517417003863	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
517417003864	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
517417003865	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
517417003866	Coenzyme A binding pocket [chemical binding]; other site
517417003867	bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566
517417003868	UbiA prenyltransferase family; Region: UbiA; pfam01040
517417003869	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
517417003870	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
517417003871	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
517417003872	active site
517417003873	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
517417003874	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
517417003875	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
517417003876	putative NAD(P) binding site [chemical binding]; other site
517417003877	putative substrate binding site [chemical binding]; other site
517417003878	catalytic Zn binding site [ion binding]; other site
517417003879	structural Zn binding site [ion binding]; other site
517417003880	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
517417003881	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
517417003882	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
517417003883	DNA binding residues [nucleotide binding]
517417003884	bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550
517417003885	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
517417003886	methionine sulfoxide reductase A; Provisional; Region: PRK14054
517417003887	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
517417003888	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
517417003889	catalytic residues [active]
517417003890	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822
517417003891	putative hydrophobic ligand binding site [chemical binding]; other site
517417003892	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
517417003893	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
517417003894	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
517417003895	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
517417003896	HlyD family secretion protein; Region: HlyD_3; pfam13437
517417003897	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
517417003898	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
517417003899	DNA binding site [nucleotide binding]
517417003900	active site
517417003901	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
517417003902	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517417003903	NAD(P) binding site [chemical binding]; other site
517417003904	active site
517417003905	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
517417003906	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
517417003907	catalytic residues [active]
517417003908	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
517417003909	active site
517417003910	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
517417003911	homodecamer interface [polypeptide binding]; other site
517417003912	GTP cyclohydrolase I; Provisional; Region: PLN03044
517417003913	active site
517417003914	putative catalytic site residues [active]
517417003915	zinc binding site [ion binding]; other site
517417003916	GTP-CH-I/GFRP interaction surface; other site
517417003917	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
517417003918	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
517417003919	putative substrate-binding site; other site
517417003920	nickel binding site [ion binding]; other site
517417003921	Ni/Fe-hydrogenase, b-type cytochrome subunit; Region: CytB-hydogenase; TIGR02125
517417003922	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
517417003923	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
517417003924	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
517417003925	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
517417003926	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
517417003927	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
517417003928	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
517417003929	proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972
517417003930	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
517417003931	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
517417003932	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
517417003933	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
517417003934	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
517417003935	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
517417003936	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
517417003937	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
517417003938	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
517417003939	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
517417003940	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
517417003941	NADH dehydrogenase subunit D; Validated; Region: PRK06075
517417003942	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
517417003943	NADH dehydrogenase subunit B; Provisional; Region: PRK14813
517417003944	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
517417003945	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517417003946	TPR motif; other site
517417003947	TPR repeat; Region: TPR_11; pfam13414
517417003948	binding surface
517417003949	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517417003950	binding surface
517417003951	TPR repeat; Region: TPR_11; pfam13414
517417003952	TPR motif; other site
517417003953	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
517417003954	Ferrochelatase; Region: Ferrochelatase; pfam00762
517417003955	C-terminal domain interface [polypeptide binding]; other site
517417003956	active site
517417003957	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
517417003958	active site
517417003959	N-terminal domain interface [polypeptide binding]; other site
517417003960	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
517417003961	nucleotide binding site/active site [active]
517417003962	HIT family signature motif; other site
517417003963	catalytic residue [active]
517417003964	Methyltransferase domain; Region: Methyltransf_23; pfam13489
517417003965	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517417003966	S-adenosylmethionine binding site [chemical binding]; other site
517417003967	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
517417003968	recombination factor protein RarA; Reviewed; Region: PRK13342
517417003969	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517417003970	Walker A motif; other site
517417003971	ATP binding site [chemical binding]; other site
517417003972	Walker B motif; other site
517417003973	arginine finger; other site
517417003974	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
517417003975	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
517417003976	Lumazine binding domain; Region: Lum_binding; pfam00677
517417003977	Lumazine binding domain; Region: Lum_binding; pfam00677
517417003978	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
517417003979	dimer interface [polypeptide binding]; other site
517417003980	catalytic triad [active]
517417003981	peroxidatic and resolving cysteines [active]
517417003982	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
517417003983	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
517417003984	Walker A/P-loop; other site
517417003985	ATP binding site [chemical binding]; other site
517417003986	Q-loop/lid; other site
517417003987	ABC transporter signature motif; other site
517417003988	Walker B; other site
517417003989	D-loop; other site
517417003990	H-loop/switch region; other site
517417003991	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517417003992	PAS fold; Region: PAS_3; pfam08447
517417003993	putative active site [active]
517417003994	heme pocket [chemical binding]; other site
517417003995	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517417003996	PAS fold; Region: PAS_3; pfam08447
517417003997	putative active site [active]
517417003998	heme pocket [chemical binding]; other site
517417003999	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
517417004000	GAF domain; Region: GAF; cl17456
517417004001	GAF domain; Region: GAF_2; pfam13185
517417004002	GAF domain; Region: GAF; pfam01590
517417004003	PAS domain S-box; Region: sensory_box; TIGR00229
517417004004	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517417004005	putative active site [active]
517417004006	heme pocket [chemical binding]; other site
517417004007	PAS domain S-box; Region: sensory_box; TIGR00229
517417004008	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517417004009	putative active site [active]
517417004010	heme pocket [chemical binding]; other site
517417004011	PAS fold; Region: PAS_3; pfam08447
517417004012	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517417004013	dimer interface [polypeptide binding]; other site
517417004014	phosphorylation site [posttranslational modification]
517417004015	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517417004016	ATP binding site [chemical binding]; other site
517417004017	Mg2+ binding site [ion binding]; other site
517417004018	G-X-G motif; other site
517417004019	Response regulator receiver domain; Region: Response_reg; pfam00072
517417004020	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517417004021	active site
517417004022	phosphorylation site [posttranslational modification]
517417004023	intermolecular recognition site; other site
517417004024	dimerization interface [polypeptide binding]; other site
517417004025	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
517417004026	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517417004027	NAD(P) binding site [chemical binding]; other site
517417004028	active site
517417004029	Heavy-metal resistance; Region: Metal_resist; pfam13801
517417004030	dimer interface [polypeptide binding]; other site
517417004031	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
517417004032	thymidylate kinase; Validated; Region: tmk; PRK00698
517417004033	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
517417004034	TMP-binding site; other site
517417004035	ATP-binding site [chemical binding]; other site
517417004036	phosphoglycolate phosphatase; Provisional; Region: PRK01158
517417004037	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
517417004038	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
517417004039	motif II; other site
517417004040	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
517417004041	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
517417004042	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
517417004043	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
517417004044	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
517417004045	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
517417004046	substrate binding site; other site
517417004047	dimer interface; other site
517417004048	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
517417004049	CoenzymeA binding site [chemical binding]; other site
517417004050	subunit interaction site [polypeptide binding]; other site
517417004051	PHB binding site; other site
517417004052	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
517417004053	B12 binding site [chemical binding]; other site
517417004054	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
517417004055	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517417004056	FeS/SAM binding site; other site
517417004057	zinc transporter ZupT; Provisional; Region: PRK04201
517417004058	ZIP Zinc transporter; Region: Zip; pfam02535
517417004059	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
517417004060	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
517417004061	dimer interface [polypeptide binding]; other site
517417004062	anticodon binding site; other site
517417004063	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
517417004064	homodimer interface [polypeptide binding]; other site
517417004065	motif 1; other site
517417004066	active site
517417004067	motif 2; other site
517417004068	GAD domain; Region: GAD; pfam02938
517417004069	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
517417004070	active site
517417004071	motif 3; other site
517417004072	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14954
517417004073	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14955
517417004074	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517417004075	Walker A motif; other site
517417004076	ATP binding site [chemical binding]; other site
517417004077	Walker B motif; other site
517417004078	arginine finger; other site
517417004079	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
517417004080	YihY family inner membrane protein; Region: yihY_not_rbn; TIGR00765
517417004081	Rubrerythrin [Energy production and conversion]; Region: COG1592
517417004082	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
517417004083	binuclear metal center [ion binding]; other site
517417004084	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
517417004085	iron binding site [ion binding]; other site
517417004086	DPS-like protein, ferritin-like diiron-binding domain; Region: DPSL; cd01052
517417004087	Ferritin-like domain; Region: Ferritin; pfam00210
517417004088	diiron binding motif [ion binding]; other site
517417004089	bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604
517417004090	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
517417004091	trimer interface [polypeptide binding]; other site
517417004092	dimer interface [polypeptide binding]; other site
517417004093	putative active site [active]
517417004094	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
517417004095	MPT binding site; other site
517417004096	trimer interface [polypeptide binding]; other site
517417004097	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
517417004098	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
517417004099	dimer interface [polypeptide binding]; other site
517417004100	putative functional site; other site
517417004101	putative MPT binding site; other site
517417004102	putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MobA; Provisional; Region: PRK14490
517417004103	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
517417004104	Walker A motif; other site
517417004105	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
517417004106	GTP binding site; other site
517417004107	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
517417004108	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517417004109	FeS/SAM binding site; other site
517417004110	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
517417004111	MOSC domain; Region: MOSC; pfam03473
517417004112	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
517417004113	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
517417004114	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
517417004115	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
517417004116	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
517417004117	putative catalytic site [active]
517417004118	putative metal binding site [ion binding]; other site
517417004119	putative phosphate binding site [ion binding]; other site
517417004120	serine acetyltransferase; Provisional; Region: cysE; PRK11132
517417004121	Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971
517417004122	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
517417004123	trimer interface [polypeptide binding]; other site
517417004124	active site
517417004125	substrate binding site [chemical binding]; other site
517417004126	CoA binding site [chemical binding]; other site
517417004127	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
517417004128	active site
517417004129	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
517417004130	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
517417004131	Probable Catalytic site; other site
517417004132	metal-binding site
517417004133	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
517417004134	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
517417004135	substrate binding site [chemical binding]; other site
517417004136	active site
517417004137	catalytic residues [active]
517417004138	heterodimer interface [polypeptide binding]; other site
517417004139	CAAX protease self-immunity; Region: Abi; pfam02517
517417004140	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
517417004141	Ligand Binding Site [chemical binding]; other site
517417004142	PAS domain; Region: PAS_8; pfam13188
517417004143	PAS domain; Region: PAS_9; pfam13426
517417004144	GAF domain; Region: GAF_2; pfam13185
517417004145	GAF domain; Region: GAF; cl17456
517417004146	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
517417004147	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517417004148	dimer interface [polypeptide binding]; other site
517417004149	phosphorylation site [posttranslational modification]
517417004150	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517417004151	ATP binding site [chemical binding]; other site
517417004152	Mg2+ binding site [ion binding]; other site
517417004153	G-X-G motif; other site
517417004154	Response regulator receiver domain; Region: Response_reg; pfam00072
517417004155	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517417004156	active site
517417004157	phosphorylation site [posttranslational modification]
517417004158	intermolecular recognition site; other site
517417004159	dimerization interface [polypeptide binding]; other site
517417004160	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
517417004161	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
517417004162	ring oligomerisation interface [polypeptide binding]; other site
517417004163	ATP/Mg binding site [chemical binding]; other site
517417004164	stacking interactions; other site
517417004165	hinge regions; other site
517417004166	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
517417004167	oligomerisation interface [polypeptide binding]; other site
517417004168	mobile loop; other site
517417004169	roof hairpin; other site
517417004170	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
517417004171	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
517417004172	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
517417004173	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
517417004174	Predicted transcriptional regulator [Transcription]; Region: COG1959
517417004175	Transcriptional regulator; Region: Rrf2; pfam02082
517417004176	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
517417004177	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
517417004178	PGAP1-like protein; Region: PGAP1; pfam07819
517417004179	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
517417004180	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
517417004181	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
517417004182	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517417004183	catalytic residue [active]
517417004184	TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305
517417004185	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
517417004186	active site residue [active]
517417004187	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
517417004188	TPR repeat; Region: TPR_11; pfam13414
517417004189	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517417004190	binding surface
517417004191	TPR motif; other site
517417004192	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
517417004193	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517417004194	binding surface
517417004195	TPR motif; other site
517417004196	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517417004197	binding surface
517417004198	TPR motif; other site
517417004199	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517417004200	binding surface
517417004201	TPR motif; other site
517417004202	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
517417004203	haemagglutination activity domain; Region: Haemagg_act; smart00912
517417004204	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
517417004205	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
517417004206	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
517417004207	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
517417004208	Surface antigen; Region: Bac_surface_Ag; pfam01103
517417004209	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
517417004210	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
517417004211	catalytic triad [active]
517417004212	photolyase PhrII; Region: phr2; TIGR00591
517417004213	DNA photolyase; Region: DNA_photolyase; pfam00875
517417004214	Putative addiction module component; Region: Unstab_antitox; pfam09720
517417004215	ribonuclease R; Region: RNase_R; TIGR02063
517417004216	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
517417004217	RNB domain; Region: RNB; pfam00773
517417004218	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
517417004219	RNA binding site [nucleotide binding]; other site
517417004220	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
517417004221	Predicted membrane protein (DUF2127); Region: DUF2127; pfam09900
517417004222	The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755
517417004223	putative [Fe4-S4] binding site [ion binding]; other site
517417004224	anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990
517417004225	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
517417004226	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
517417004227	The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778
517417004228	putative molybdopterin cofactor binding site; other site
517417004229	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
517417004230	Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301
517417004231	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
517417004232	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
517417004233	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
517417004234	Uncharacterized conserved protein [Function unknown]; Region: COG3410
517417004235	Domain of unknown function (DUF389); Region: DUF389; pfam04087
517417004236	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
517417004237	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
517417004238	transmembrane helices; other site
517417004239	putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827
517417004240	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
517417004241	Na binding site [ion binding]; other site
517417004242	lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820
517417004243	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517417004244	FeS/SAM binding site; other site
517417004245	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
517417004246	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
517417004247	MarR family; Region: MarR; pfam01047
517417004248	MarR family; Region: MarR_2; cl17246
517417004249	Protein of unknown function, DUF481; Region: DUF481; pfam04338
517417004250	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
517417004251	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
517417004252	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
517417004253	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
517417004254	TIR domain; Region: TIR_2; pfam13676
517417004255	NACHT domain; Region: NACHT; pfam05729
517417004256	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
517417004257	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
517417004258	FOG: WD40 repeat [General function prediction only]; Region: COG2319
517417004259	WD domain, G-beta repeat; Region: WD40; pfam00400
517417004260	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
517417004261	structural tetrad; other site
517417004262	WD40 repeats; Region: WD40; smart00320
517417004263	FOG: WD40 repeat [General function prediction only]; Region: COG2319
517417004264	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
517417004265	structural tetrad; other site
517417004266	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
517417004267	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599
517417004268	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651
517417004269	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
517417004270	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12659
517417004271	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12509
517417004272	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647
517417004273	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
517417004274	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
517417004275	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
517417004276	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
517417004277	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
517417004278	NAD(P) binding site [chemical binding]; other site
517417004279	putative active site [active]
517417004280	peroxiredoxin; Provisional; Region: PRK13189
517417004281	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
517417004282	dimer interface [polypeptide binding]; other site
517417004283	decamer (pentamer of dimers) interface [polypeptide binding]; other site
517417004284	catalytic triad [active]
517417004285	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
517417004286	dimer interface [polypeptide binding]; other site
517417004287	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
517417004288	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
517417004289	nucleotide binding site [chemical binding]; other site
517417004290	putative NEF/HSP70 interaction site [polypeptide binding]; other site
517417004291	SBD interface [polypeptide binding]; other site
517417004292	Ycf46; Provisional; Region: ycf46; CHL00195
517417004293	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517417004294	Walker A motif; other site
517417004295	ATP binding site [chemical binding]; other site
517417004296	Walker B motif; other site
517417004297	arginine finger; other site
517417004298	Uncharacterized conserved protein [Function unknown]; Region: COG1262
517417004299	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
517417004300	Universal stress protein family; Region: Usp; pfam00582
517417004301	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
517417004302	Ligand Binding Site [chemical binding]; other site
517417004303	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
517417004304	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
517417004305	Sulfate transporter family; Region: Sulfate_transp; pfam00916
517417004306	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
517417004307	asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104
517417004308	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
517417004309	active site
517417004310	dimer interface [polypeptide binding]; other site
517417004311	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
517417004312	Ligand Binding Site [chemical binding]; other site
517417004313	Molecular Tunnel; other site
517417004314	GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT
517417004315	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
517417004316	Coenzyme A binding pocket [chemical binding]; other site
517417004317	ATP-grasp domain; Region: ATP-grasp_4; cl17255
517417004318	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
517417004319	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
517417004320	putative oligomer interface [polypeptide binding]; other site
517417004321	putative active site [active]
517417004322	metal binding site [ion binding]; metal-binding site
517417004323	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
517417004324	nucleoside/Zn binding site; other site
517417004325	dimer interface [polypeptide binding]; other site
517417004326	catalytic motif [active]
517417004327	FeoA domain; Region: FeoA; pfam04023
517417004328	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
517417004329	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
517417004330	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
517417004331	G1 box; other site
517417004332	GTP/Mg2+ binding site [chemical binding]; other site
517417004333	Switch I region; other site
517417004334	G2 box; other site
517417004335	G3 box; other site
517417004336	Switch II region; other site
517417004337	G4 box; other site
517417004338	G5 box; other site
517417004339	Nucleoside recognition; Region: Gate; pfam07670
517417004340	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
517417004341	Nucleoside recognition; Region: Gate; pfam07670
517417004342	FeoC like transcriptional regulator; Region: FeoC; pfam09012
517417004343	Protein of unknown function (DUF2023); Region: DUF2023; pfam09633
517417004344	Protein of unknown function (DUF1318); Region: DUF1318; pfam07027
517417004345	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
517417004346	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
517417004347	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
517417004348	substrate binding site [chemical binding]; other site
517417004349	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
517417004350	substrate binding site [chemical binding]; other site
517417004351	ligand binding site [chemical binding]; other site
517417004352	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
517417004353	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
517417004354	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
517417004355	histidinol dehydrogenase; Region: hisD; TIGR00069
517417004356	NAD binding site [chemical binding]; other site
517417004357	dimerization interface [polypeptide binding]; other site
517417004358	product binding site; other site
517417004359	substrate binding site [chemical binding]; other site
517417004360	zinc binding site [ion binding]; other site
517417004361	catalytic residues [active]
517417004362	rod shape-determining protein MreB; Provisional; Region: PRK13930
517417004363	MreB and similar proteins; Region: MreB_like; cd10225
517417004364	nucleotide binding site [chemical binding]; other site
517417004365	Mg binding site [ion binding]; other site
517417004366	putative protofilament interaction site [polypeptide binding]; other site
517417004367	RodZ interaction site [polypeptide binding]; other site
517417004368	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
517417004369	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
517417004370	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381
517417004371	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
517417004372	Ligand binding site; other site
517417004373	Putative Catalytic site; other site
517417004374	DXD motif; other site
517417004375	Uncharacterized membrane protein, required for N-linked glycosylation [General function prediction only]; Region: COG1287
517417004376	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
517417004377	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
517417004378	substrate binding site; other site
517417004379	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
517417004380	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
517417004381	NAD binding site [chemical binding]; other site
517417004382	homotetramer interface [polypeptide binding]; other site
517417004383	homodimer interface [polypeptide binding]; other site
517417004384	substrate binding site [chemical binding]; other site
517417004385	active site
517417004386	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
517417004387	lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407
517417004388	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
517417004389	inhibitor-cofactor binding pocket; inhibition site
517417004390	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517417004391	catalytic residue [active]
517417004392	Methyltransferase domain; Region: Methyltransf_23; pfam13489
517417004393	Methyltransferase domain; Region: Methyltransf_12; pfam08242
517417004394	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
517417004395	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
517417004396	PYR/PP interface [polypeptide binding]; other site
517417004397	dimer interface [polypeptide binding]; other site
517417004398	TPP binding site [chemical binding]; other site
517417004399	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
517417004400	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
517417004401	TPP-binding site [chemical binding]; other site
517417004402	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
517417004403	classical (c) SDRs; Region: SDR_c; cd05233
517417004404	NAD(P) binding site [chemical binding]; other site
517417004405	active site
517417004406	Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like1; cd08196
517417004407	putative active site [active]
517417004408	metal binding site [ion binding]; metal-binding site
517417004409	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
517417004410	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
517417004411	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
517417004412	NAD(P) binding site [chemical binding]; other site
517417004413	active site
517417004414	GtrA-like protein; Region: GtrA; pfam04138
517417004415	Predicted membrane protein [Function unknown]; Region: COG2246
517417004416	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
517417004417	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
517417004418	Ligand binding site; other site
517417004419	Putative Catalytic site; other site
517417004420	DXD motif; other site
517417004421	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
517417004422	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
517417004423	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
517417004424	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
517417004425	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
517417004426	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
517417004427	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
517417004428	ATP binding site [chemical binding]; other site
517417004429	Walker A motif; other site
517417004430	hexamer interface [polypeptide binding]; other site
517417004431	Walker B motif; other site
517417004432	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
517417004433	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
517417004434	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
517417004435	Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977
517417004436	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
517417004437	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
517417004438	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
517417004439	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
517417004440	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
517417004441	Flp/Fap pilin component; Region: Flp_Fap; cl01585
517417004442	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922
517417004443	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
517417004444	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
517417004445	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
517417004446	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
517417004447	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
517417004448	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
517417004449	active site
517417004450	SAM binding site [chemical binding]; other site
517417004451	homodimer interface [polypeptide binding]; other site
517417004452	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
517417004453	active site
517417004454	putative homodimer interface [polypeptide binding]; other site
517417004455	SAM binding site [chemical binding]; other site
517417004456	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517417004457	S-adenosylmethionine binding site [chemical binding]; other site
517417004458	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
517417004459	active site
517417004460	SAM binding site [chemical binding]; other site
517417004461	homodimer interface [polypeptide binding]; other site
517417004462	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
517417004463	Precorrin-8X methylmutase; Region: CbiC; pfam02570
517417004464	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
517417004465	active site
517417004466	SAM binding site [chemical binding]; other site
517417004467	homodimer interface [polypeptide binding]; other site
517417004468	Cobalt chelatase (CbiK); Region: CbiK; pfam06180
517417004469	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412
517417004470	active site
517417004471	C-terminal domain interface [polypeptide binding]; other site
517417004472	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
517417004473	active site
517417004474	N-terminal domain interface [polypeptide binding]; other site
517417004475	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
517417004476	Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798
517417004477	active site
517417004478	SAM binding site [chemical binding]; other site
517417004479	homodimer interface [polypeptide binding]; other site
517417004480	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13636
517417004481	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
517417004482	Walker A/P-loop; other site
517417004483	ATP binding site [chemical binding]; other site
517417004484	Q-loop/lid; other site
517417004485	ABC transporter signature motif; other site
517417004486	Walker B; other site
517417004487	D-loop; other site
517417004488	H-loop/switch region; other site
517417004489	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
517417004490	cobalt transport protein CbiN; Provisional; Region: PRK02898
517417004491	cobalt transport protein CbiM; Validated; Region: PRK08319
517417004492	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
517417004493	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
517417004494	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
517417004495	Methyltransferase domain; Region: Methyltransf_31; pfam13847
517417004496	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517417004497	S-adenosylmethionine binding site [chemical binding]; other site
517417004498	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
517417004499	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
517417004500	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517417004501	Walker A motif; other site
517417004502	ATP binding site [chemical binding]; other site
517417004503	Walker B motif; other site
517417004504	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
517417004505	Domain of unknown function (DUF4404); Region: DUF4404; pfam14357
517417004506	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
517417004507	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
517417004508	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
517417004509	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
517417004510	active site
517417004511	dimer interface [polypeptide binding]; other site
517417004512	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
517417004513	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
517417004514	active site
517417004515	FMN binding site [chemical binding]; other site
517417004516	substrate binding site [chemical binding]; other site
517417004517	3Fe-4S cluster binding site [ion binding]; other site
517417004518	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
517417004519	domain interface; other site
517417004520	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
517417004521	catalytic core [active]
517417004522	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
517417004523	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
517417004524	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
517417004525	FMN binding site [chemical binding]; other site
517417004526	substrate binding site [chemical binding]; other site
517417004527	putative catalytic residue [active]
517417004528	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
517417004529	nucleoside/Zn binding site; other site
517417004530	dimer interface [polypeptide binding]; other site
517417004531	catalytic motif [active]
517417004532	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
517417004533	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
517417004534	CoA-ligase; Region: Ligase_CoA; pfam00549
517417004535	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
517417004536	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
517417004537	Walker A/P-loop; other site
517417004538	ATP binding site [chemical binding]; other site
517417004539	Q-loop/lid; other site
517417004540	ABC transporter signature motif; other site
517417004541	Walker B; other site
517417004542	D-loop; other site
517417004543	H-loop/switch region; other site
517417004544	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
517417004545	FtsX-like permease family; Region: FtsX; pfam02687
517417004546	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
517417004547	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
517417004548	HlyD family secretion protein; Region: HlyD_3; pfam13437
517417004549	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
517417004550	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
517417004551	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
517417004552	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
517417004553	ABC transporter; Region: ABC_tran_2; pfam12848
517417004554	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
517417004555	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
517417004556	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
517417004557	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
517417004558	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
517417004559	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
517417004560	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517417004561	FeS/SAM binding site; other site
517417004562	HemN C-terminal domain; Region: HemN_C; pfam06969
517417004563	AIR carboxylase; Region: AIRC; pfam00731
517417004564	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
517417004565	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
517417004566	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
517417004567	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
517417004568	acetylornithine aminotransferase; Provisional; Region: PRK02627
517417004569	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
517417004570	inhibitor-cofactor binding pocket; inhibition site
517417004571	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517417004572	catalytic residue [active]
517417004573	Protein of unknown function (DUF3098); Region: DUF3098; pfam11297
517417004574	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
517417004575	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
517417004576	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
517417004577	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
517417004578	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
517417004579	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
517417004580	DNA primase; Validated; Region: dnaG; PRK05667
517417004581	CHC2 zinc finger; Region: zf-CHC2; pfam01807
517417004582	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
517417004583	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
517417004584	active site
517417004585	metal binding site [ion binding]; metal-binding site
517417004586	interdomain interaction site; other site
517417004587	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
517417004588	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
517417004589	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
517417004590	dimer interface [polypeptide binding]; other site
517417004591	active site
517417004592	glycine-pyridoxal phosphate binding site [chemical binding]; other site
517417004593	folate binding site [chemical binding]; other site
517417004594	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
517417004595	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
517417004596	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
517417004597	dimerization interface [polypeptide binding]; other site
517417004598	active site
517417004599	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096
517417004600	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
517417004601	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
517417004602	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
517417004603	ATP-grasp domain; Region: ATP-grasp_4; cl17255
517417004604	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
517417004605	IMP binding site; other site
517417004606	dimer interface [polypeptide binding]; other site
517417004607	partial ornithine binding site; other site
517417004608	Putative molybdenum carrier; Region: MoCo_carrier; pfam12694
517417004609	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
517417004610	Ferritin-like domain; Region: Ferritin; pfam00210
517417004611	ferroxidase diiron center [ion binding]; other site
517417004612	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
517417004613	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
517417004614	putative active site [active]
517417004615	putative metal binding site [ion binding]; other site
517417004616	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
517417004617	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
517417004618	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
517417004619	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
517417004620	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
517417004621	heterodimer interface [polypeptide binding]; other site
517417004622	active site
517417004623	FMN binding site [chemical binding]; other site
517417004624	homodimer interface [polypeptide binding]; other site
517417004625	substrate binding site [chemical binding]; other site
517417004626	Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
517417004627	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
517417004628	homotrimer interaction site [polypeptide binding]; other site
517417004629	zinc binding site [ion binding]; other site
517417004630	CDP-binding sites; other site
517417004631	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
517417004632	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
517417004633	FtsX-like permease family; Region: FtsX; pfam02687
517417004634	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
517417004635	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
517417004636	active site
517417004637	ADP/pyrophosphate binding site [chemical binding]; other site
517417004638	allosteric effector site; other site
517417004639	dimerization interface [polypeptide binding]; other site
517417004640	fructose-1,6-bisphosphate binding site; other site
517417004641	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
517417004642	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
517417004643	homodimer interface [polypeptide binding]; other site
517417004644	substrate-cofactor binding pocket; other site
517417004645	catalytic residue [active]
517417004646	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
517417004647	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
517417004648	Walker A motif; other site
517417004649	ATP binding site [chemical binding]; other site
517417004650	DNA polymerase III subunit delta'; Validated; Region: PRK05564
517417004651	DNA polymerase III subunit delta'; Validated; Region: PRK08485
517417004652	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
517417004653	Domain of unknown function DUF21; Region: DUF21; pfam01595
517417004654	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
517417004655	Transporter associated domain; Region: CorC_HlyC; smart01091
517417004656	S-adenosylmethionine synthetase; Provisional; Region: PRK04439
517417004657	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
517417004658	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
517417004659	motif II; other site
517417004660	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866
517417004661	putative hydrophobic ligand binding site [chemical binding]; other site
517417004662	Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731
517417004663	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517417004664	FeS/SAM binding site; other site
517417004665	PUCC protein; Region: PUCC; pfam03209
517417004666	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
517417004667	ThiC-associated domain; Region: ThiC-associated; pfam13667
517417004668	ThiC family; Region: ThiC; pfam01964
517417004669	triosephosphate isomerase; Provisional; Region: PRK14567
517417004670	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
517417004671	substrate binding site [chemical binding]; other site
517417004672	dimer interface [polypeptide binding]; other site
517417004673	catalytic triad [active]
517417004674	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
517417004675	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
517417004676	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
517417004677	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
517417004678	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
517417004679	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
517417004680	protein binding site [polypeptide binding]; other site
517417004681	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
517417004682	protein binding site [polypeptide binding]; other site
517417004683	anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
517417004684	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
517417004685	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
517417004686	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
517417004687	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
517417004688	Catalytic site [active]
517417004689	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
517417004690	GTP-binding protein LepA; Provisional; Region: PRK05433
517417004691	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
517417004692	G1 box; other site
517417004693	putative GEF interaction site [polypeptide binding]; other site
517417004694	GTP/Mg2+ binding site [chemical binding]; other site
517417004695	Switch I region; other site
517417004696	G2 box; other site
517417004697	G3 box; other site
517417004698	Switch II region; other site
517417004699	G4 box; other site
517417004700	G5 box; other site
517417004701	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
517417004702	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
517417004703	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
517417004704	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
517417004705	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
517417004706	putative active site [active]
517417004707	substrate binding site [chemical binding]; other site
517417004708	putative cosubstrate binding site; other site
517417004709	catalytic site [active]
517417004710	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
517417004711	substrate binding site [chemical binding]; other site
517417004712	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
517417004713	active site
517417004714	catalytic residues [active]
517417004715	metal binding site [ion binding]; metal-binding site
517417004716	ferric uptake regulator; Provisional; Region: fur; PRK09462
517417004717	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
517417004718	metal binding site 2 [ion binding]; metal-binding site
517417004719	putative DNA binding helix; other site
517417004720	metal binding site 1 [ion binding]; metal-binding site
517417004721	dimer interface [polypeptide binding]; other site
517417004722	structural Zn2+ binding site [ion binding]; other site
517417004723	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
517417004724	gamma-glutamyl kinase; Provisional; Region: PRK05429
517417004725	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
517417004726	nucleotide binding site [chemical binding]; other site
517417004727	homotetrameric interface [polypeptide binding]; other site
517417004728	putative phosphate binding site [ion binding]; other site
517417004729	putative allosteric binding site; other site
517417004730	PUA domain; Region: PUA; pfam01472
517417004731	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517417004732	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517417004733	binding surface
517417004734	TPR motif; other site
517417004735	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517417004736	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517417004737	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517417004738	Tetratricopeptide repeat; Region: TPR_10; pfam13374
517417004739	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517417004740	Tetratricopeptide repeat; Region: TPR_10; pfam13374
517417004741	Tetratricopeptide repeat; Region: TPR_10; pfam13374
517417004742	Tetratricopeptide repeat; Region: TPR_10; cl17452
517417004743	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517417004744	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517417004745	binding surface
517417004746	TPR motif; other site
517417004747	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517417004748	Tetratricopeptide repeat; Region: TPR_12; pfam13424
517417004749	Tetratricopeptide repeat; Region: TPR_10; cl17452
517417004750	Predicted flavoprotein [General function prediction only]; Region: COG0431
517417004751	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
517417004752	Domain of unknown function (DUF4403); Region: DUF4403; pfam14356
517417004753	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
517417004754	active site
517417004755	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
517417004756	putative FMN binding site [chemical binding]; other site
517417004757	rod shape-determining protein MreB; Provisional; Region: PRK13930
517417004758	MreB and similar proteins; Region: MreB_like; cd10225
517417004759	nucleotide binding site [chemical binding]; other site
517417004760	Mg binding site [ion binding]; other site
517417004761	putative protofilament interaction site [polypeptide binding]; other site
517417004762	RodZ interaction site [polypeptide binding]; other site
517417004763	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920
517417004764	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
517417004765	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517417004766	FeS/SAM binding site; other site
517417004767	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
517417004768	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
517417004769	amphipathic channel; other site
517417004770	Asn-Pro-Ala signature motifs; other site
517417004771	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
517417004772	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
517417004773	putative catalytic cysteine [active]
517417004774	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
517417004775	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
517417004776	Walker A/P-loop; other site
517417004777	ATP binding site [chemical binding]; other site
517417004778	Q-loop/lid; other site
517417004779	ABC transporter signature motif; other site
517417004780	Walker B; other site
517417004781	D-loop; other site
517417004782	H-loop/switch region; other site
517417004783	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
517417004784	Major Facilitator Superfamily; Region: MFS_1; pfam07690
517417004785	putative substrate translocation pore; other site
517417004786	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
517417004787	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
517417004788	inhibitor-cofactor binding pocket; inhibition site
517417004789	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517417004790	catalytic residue [active]
517417004791	UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773
517417004792	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
517417004793	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
517417004794	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
517417004795	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
517417004796	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
517417004797	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
517417004798	Flavodoxin domain; Region: Flavodoxin_5; cl17428
517417004799	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
517417004800	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
517417004801	chaperone protein DnaJ; Provisional; Region: PRK14281
517417004802	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
517417004803	HSP70 interaction site [polypeptide binding]; other site
517417004804	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
517417004805	substrate binding site [polypeptide binding]; other site
517417004806	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
517417004807	Zn binding sites [ion binding]; other site
517417004808	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
517417004809	dimer interface [polypeptide binding]; other site
517417004810	GrpE; Region: GrpE; pfam01025
517417004811	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
517417004812	dimer interface [polypeptide binding]; other site
517417004813	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
517417004814	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
517417004815	heat shock gene repressor HrcA; Region: hrcA; TIGR00331
517417004816	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
517417004817	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517417004818	S-adenosylmethionine binding site [chemical binding]; other site
517417004819	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
517417004820	prolyl-tRNA synthetase; Provisional; Region: PRK08661
517417004821	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
517417004822	dimer interface [polypeptide binding]; other site
517417004823	motif 1; other site
517417004824	active site
517417004825	motif 2; other site
517417004826	motif 3; other site
517417004827	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
517417004828	anticodon binding site; other site
517417004829	zinc-binding site [ion binding]; other site
517417004830	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
517417004831	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
517417004832	dimer interface [polypeptide binding]; other site
517417004833	decamer (pentamer of dimers) interface [polypeptide binding]; other site
517417004834	catalytic triad [active]
517417004835	peroxidatic and resolving cysteines [active]
517417004836	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
517417004837	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_8; cd07586
517417004838	Predicted amidohydrolase [General function prediction only]; Region: COG0388
517417004839	putative active site [active]
517417004840	catalytic triad [active]
517417004841	putative dimer interface [polypeptide binding]; other site
517417004842	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14616
517417004843	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
517417004844	Sporulation related domain; Region: SPOR; pfam05036
517417004845	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
517417004846	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517417004847	Walker A motif; other site
517417004848	ATP binding site [chemical binding]; other site
517417004849	Walker B motif; other site
517417004850	arginine finger; other site
517417004851	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
517417004852	Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241
517417004853	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
517417004854	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
517417004855	putative active site [active]
517417004856	catalytic triad [active]
517417004857	putative dimer interface [polypeptide binding]; other site
517417004858	Bacteriochlorophyll A protein; Region: BChl_A; pfam02327
517417004859	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
517417004860	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
517417004861	DNA binding residues [nucleotide binding]
517417004862	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
517417004863	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
517417004864	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
517417004865	Walker A/P-loop; other site
517417004866	ATP binding site [chemical binding]; other site
517417004867	Q-loop/lid; other site
517417004868	ABC transporter signature motif; other site
517417004869	Walker B; other site
517417004870	D-loop; other site
517417004871	H-loop/switch region; other site
517417004872	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
517417004873	B12 binding site [chemical binding]; other site
517417004874	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
517417004875	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517417004876	FeS/SAM binding site; other site
517417004877	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
517417004878	MutS domain I; Region: MutS_I; pfam01624
517417004879	MutS domain II; Region: MutS_II; pfam05188
517417004880	MutS domain III; Region: MutS_III; pfam05192
517417004881	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
517417004882	Walker A/P-loop; other site
517417004883	ATP binding site [chemical binding]; other site
517417004884	Q-loop/lid; other site
517417004885	ABC transporter signature motif; other site
517417004886	Walker B; other site
517417004887	D-loop; other site
517417004888	H-loop/switch region; other site
517417004889	Copper resistance protein D; Region: CopD; pfam05425
517417004890	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
517417004891	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
517417004892	malate dehydrogenase; Reviewed; Region: PRK06223
517417004893	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
517417004894	NAD(P) binding site [chemical binding]; other site
517417004895	dimer interface [polypeptide binding]; other site
517417004896	tetramer (dimer of dimers) interface [polypeptide binding]; other site
517417004897	substrate binding site [chemical binding]; other site
517417004898	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
517417004899	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
517417004900	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
517417004901	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
517417004902	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
517417004903	Peptidase family M48; Region: Peptidase_M48; pfam01435
517417004904	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
517417004905	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
517417004906	putative active site; other site
517417004907	catalytic triad [active]
517417004908	putative dimer interface [polypeptide binding]; other site
517417004909	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
517417004910	UbiA prenyltransferase family; Region: UbiA; pfam01040
517417004911	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
517417004912	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
517417004913	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
517417004914	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
517417004915	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
517417004916	substrate binding site [chemical binding]; other site
517417004917	glutamase interaction surface [polypeptide binding]; other site
517417004918	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547
517417004919	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
517417004920	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
517417004921	putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574
517417004922	Transposase IS200 like; Region: Y1_Tnp; cl00848
517417004923	putative phosphoketolase; Provisional; Region: PRK05261
517417004924	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
517417004925	TPP-binding site; other site
517417004926	XFP C-terminal domain; Region: XFP_C; pfam09363
517417004927	propionate/acetate kinase; Provisional; Region: PRK12379
517417004928	Acetokinase family; Region: Acetate_kinase; cl17229
517417004929	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
517417004930	active site
517417004931	homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660
517417004932	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
517417004933	active site
517417004934	catalytic residues [active]
517417004935	metal binding site [ion binding]; metal-binding site
517417004936	Nif-specific regulatory protein; Region: nifA; TIGR01817
517417004937	GAF domain; Region: GAF; pfam01590
517417004938	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517417004939	Walker A motif; other site
517417004940	ATP binding site [chemical binding]; other site
517417004941	Walker B motif; other site
517417004942	arginine finger; other site
517417004943	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
517417004944	nitrogenase reductase; Reviewed; Region: nifH; PRK13235
517417004945	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
517417004946	Nucleotide-binding sites [chemical binding]; other site
517417004947	Walker A motif; other site
517417004948	Switch I region of nucleotide binding site; other site
517417004949	Fe4S4 binding sites [ion binding]; other site
517417004950	Switch II region of nucleotide binding site; other site
517417004951	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
517417004952	Nitrogen regulatory protein P-II; Region: P-II; smart00938
517417004953	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
517417004954	Nitrogen regulatory protein P-II; Region: P-II; smart00938
517417004955	nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284
517417004956	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
517417004957	MoFe protein alpha/beta subunit interactions; other site
517417004958	Alpha subunit P cluster binding residues; other site
517417004959	FeMoco binding residues [chemical binding]; other site
517417004960	MoFe protein alpha subunit/Fe protein contacts; other site
517417004961	MoFe protein dimer/ dimer interactions; other site
517417004962	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
517417004963	MoFe protein beta/alpha subunit interactions; other site
517417004964	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
517417004965	Beta subunit P cluster binding residues; other site
517417004966	MoFe protein beta subunit/Fe protein contacts; other site
517417004967	MoFe protein dimer/ dimer interactions; other site
517417004968	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
517417004969	Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN.  NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968
517417004970	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
517417004971	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
517417004972	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
517417004973	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517417004974	FeS/SAM binding site; other site
517417004975	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
517417004976	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
517417004977	dimer interface [polypeptide binding]; other site
517417004978	[2Fe-2S] cluster binding site [ion binding]; other site
517417004979	Cytochrome c; Region: Cytochrom_C; pfam00034
517417004980	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
517417004981	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
517417004982	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
517417004983	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
517417004984	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
517417004985	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
517417004986	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
517417004987	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517417004988	FeS/SAM binding site; other site
517417004989	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
517417004990	dimerization interface [polypeptide binding]; other site
517417004991	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
517417004992	ATP binding site [chemical binding]; other site
517417004993	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
517417004994	Sel1-like repeats; Region: SEL1; smart00671
517417004995	Sel1-like repeats; Region: SEL1; smart00671
517417004996	Sel1-like repeats; Region: SEL1; smart00671
517417004997	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
517417004998	Sel1-like repeats; Region: SEL1; smart00671
517417004999	Sel1-like repeats; Region: SEL1; smart00671
517417005000	Sel1-like repeats; Region: SEL1; smart00671
517417005001	Sel1-like repeats; Region: SEL1; smart00671
517417005002	Sel1-like repeats; Region: SEL1; smart00671
517417005003	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
517417005004	Sel1-like repeats; Region: SEL1; smart00671
517417005005	Sel1-like repeats; Region: SEL1; smart00671
517417005006	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
517417005007	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
517417005008	HupF/HypC family; Region: HupF_HypC; pfam01455
517417005009	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
517417005010	four helix bundle protein; Region: TIGR02436
517417005011	Acylphosphatase; Region: Acylphosphatase; pfam00708
517417005012	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
517417005013	HypF finger; Region: zf-HYPF; pfam07503
517417005014	HypF finger; Region: zf-HYPF; pfam07503
517417005015	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
517417005016	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
517417005017	G1 box; other site
517417005018	GTP/Mg2+ binding site [chemical binding]; other site
517417005019	G2 box; other site
517417005020	Switch I region; other site
517417005021	G3 box; other site
517417005022	Switch II region; other site
517417005023	G4 box; other site
517417005024	G5 box; other site
517417005025	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
517417005026	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
517417005027	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
517417005028	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
517417005029	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
517417005030	Protein of unknown function (DUF1207); Region: DUF1207; pfam06727
517417005031	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
517417005032	nudix motif; other site
517417005033	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
517417005034	excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14671
517417005035	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
517417005036	GIY-YIG motif/motif A; other site
517417005037	active site
517417005038	catalytic site [active]
517417005039	putative DNA binding site [nucleotide binding]; other site
517417005040	metal binding site [ion binding]; metal-binding site
517417005041	UvrB/uvrC motif; Region: UVR; pfam02151
517417005042	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
517417005043	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
517417005044	putative DNA binding site [nucleotide binding]; other site
517417005045	TPR repeat; Region: TPR_11; pfam13414
517417005046	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517417005047	binding surface
517417005048	TPR motif; other site
517417005049	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517417005050	binding surface
517417005051	TPR repeat; Region: TPR_11; pfam13414
517417005052	TPR motif; other site
517417005053	TPR repeat; Region: TPR_11; pfam13414
517417005054	TPR repeat; Region: TPR_11; pfam13414
517417005055	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517417005056	binding surface
517417005057	TPR motif; other site
517417005058	TPR repeat; Region: TPR_11; pfam13414
517417005059	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517417005060	binding surface
517417005061	TPR motif; other site
517417005062	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517417005063	binding surface
517417005064	TPR motif; other site
517417005065	TPR repeat; Region: TPR_11; pfam13414
517417005066	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
517417005067	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
517417005068	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
517417005069	shikimate binding site; other site
517417005070	NAD(P) binding site [chemical binding]; other site
517417005071	lipoprotein signal peptidase; Provisional; Region: PRK14787
517417005072	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
517417005073	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
517417005074	active site
517417005075	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
517417005076	active site
517417005077	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
517417005078	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
517417005079	catalytic residue [active]
517417005080	purine nucleoside phosphorylase; Provisional; Region: PRK08202
517417005081	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
517417005082	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
517417005083	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
517417005084	Low-spin heme binding site [chemical binding]; other site
517417005085	D-pathway; other site
517417005086	Putative water exit pathway; other site
517417005087	Binuclear center (active site) [active]
517417005088	K-pathway; other site
517417005089	Putative proton exit pathway; other site
517417005090	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
517417005091	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cl00282
517417005092	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
517417005093	4Fe-4S binding domain; Region: Fer4_5; pfam12801
517417005094	4Fe-4S dicluster domain; Region: Fer4_18; pfam13746
517417005095	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
517417005096	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
517417005097	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
517417005098	FixH; Region: FixH; pfam05751
517417005099	YtkA-like; Region: YtkA; pfam13115
517417005100	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
517417005101	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
517417005102	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
517417005103	metal-binding site [ion binding]
517417005104	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
517417005105	Soluble P-type ATPase [General function prediction only]; Region: COG4087
517417005106	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
517417005107	Family description; Region: DsbD_2; pfam13386
517417005108	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
517417005109	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
517417005110	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
517417005111	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
517417005112	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
517417005113	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
517417005114	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
517417005115	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
517417005116	Walker A/P-loop; other site
517417005117	ATP binding site [chemical binding]; other site
517417005118	Q-loop/lid; other site
517417005119	ABC transporter signature motif; other site
517417005120	Walker B; other site
517417005121	D-loop; other site
517417005122	H-loop/switch region; other site
517417005123	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
517417005124	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
517417005125	Walker A/P-loop; other site
517417005126	ATP binding site [chemical binding]; other site
517417005127	Q-loop/lid; other site
517417005128	ABC transporter signature motif; other site
517417005129	Walker B; other site
517417005130	D-loop; other site
517417005131	H-loop/switch region; other site
517417005132	Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040
517417005133	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
517417005134	NACHT domain; Region: NACHT; pfam05729
517417005135	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
517417005136	Walker A/P-loop; other site
517417005137	ATP binding site [chemical binding]; other site
517417005138	Q-loop/lid; other site
517417005139	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
517417005140	Uncharacterized conserved protein [Function unknown]; Region: COG1262
517417005141	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
517417005142	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
517417005143	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
517417005144	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
517417005145	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
517417005146	putative active site [active]
517417005147	putative substrate binding site [chemical binding]; other site
517417005148	putative cosubstrate binding site; other site
517417005149	catalytic site [active]
517417005150	Bacterial Ig-like domain; Region: Big_5; pfam13205
517417005151	Bacterial Ig-like domain; Region: Big_5; pfam13205
517417005152	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
517417005153	active site
517417005154	catalytic residues [active]
517417005155	PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389
517417005156	active site
517417005157	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
517417005158	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
517417005159	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
517417005160	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
517417005161	DHH family; Region: DHH; pfam01368
517417005162	DHHA1 domain; Region: DHHA1; pfam02272
517417005163	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
517417005164	AMP binding site [chemical binding]; other site
517417005165	metal binding site [ion binding]; metal-binding site
517417005166	active site
517417005167	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
517417005168	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
517417005169	putative active site [active]
517417005170	metal binding site [ion binding]; metal-binding site
517417005171	homodimer binding site [polypeptide binding]; other site
517417005172	Pirin-related protein [General function prediction only]; Region: COG1741
517417005173	Pirin; Region: Pirin; pfam02678
517417005174	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
517417005175	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
517417005176	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
517417005177	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
517417005178	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
517417005179	Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561
517417005180	NAD binding site [chemical binding]; other site
517417005181	homotetramer interface [polypeptide binding]; other site
517417005182	homodimer interface [polypeptide binding]; other site
517417005183	substrate binding site [chemical binding]; other site
517417005184	active site
517417005185	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
517417005186	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
517417005187	P loop; other site
517417005188	Nucleotide binding site [chemical binding]; other site
517417005189	DTAP/Switch II; other site
517417005190	Switch I; other site
517417005191	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
517417005192	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
517417005193	FMN binding site [chemical binding]; other site
517417005194	dimer interface [polypeptide binding]; other site
517417005195	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
517417005196	Flavoprotein; Region: Flavoprotein; cl08021
517417005197	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
517417005198	aromatic arch; other site
517417005199	DCoH dimer interaction site [polypeptide binding]; other site
517417005200	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
517417005201	DCoH tetramer interaction site [polypeptide binding]; other site
517417005202	substrate binding site [chemical binding]; other site
517417005203	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347
517417005204	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
517417005205	active site
517417005206	catalytic site [active]
517417005207	Uncharacterized conserved protein [Function unknown]; Region: COG0432
517417005208	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
517417005209	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
517417005210	TPP-binding site; other site
517417005211	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
517417005212	PYR/PP interface [polypeptide binding]; other site
517417005213	dimer interface [polypeptide binding]; other site
517417005214	TPP binding site [chemical binding]; other site
517417005215	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
517417005216	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
517417005217	tetramer interfaces [polypeptide binding]; other site
517417005218	binuclear metal-binding site [ion binding]; other site
517417005219	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
517417005220	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
517417005221	MutS domain III; Region: MutS_III; pfam05192
517417005222	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
517417005223	Walker A/P-loop; other site
517417005224	ATP binding site [chemical binding]; other site
517417005225	Q-loop/lid; other site
517417005226	ABC transporter signature motif; other site
517417005227	Walker B; other site
517417005228	D-loop; other site
517417005229	H-loop/switch region; other site
517417005230	Smr domain; Region: Smr; pfam01713
517417005231	Na+/H+ antiporter 1; Region: Na_H_antiport_1; pfam06965
517417005232	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
517417005233	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
517417005234	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
517417005235	active site
517417005236	hydrophilic channel; other site
517417005237	dimerization interface [polypeptide binding]; other site
517417005238	catalytic residues [active]
517417005239	active site lid [active]
517417005240	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
517417005241	active site
517417005242	dimerization interface [polypeptide binding]; other site
517417005243	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
517417005244	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
517417005245	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
517417005246	active site
517417005247	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
517417005248	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
517417005249	Permease; Region: Permease; pfam02405
517417005250	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
517417005251	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
517417005252	Walker A/P-loop; other site
517417005253	ATP binding site [chemical binding]; other site
517417005254	Q-loop/lid; other site
517417005255	ABC transporter signature motif; other site
517417005256	Walker B; other site
517417005257	D-loop; other site
517417005258	H-loop/switch region; other site
517417005259	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
517417005260	mce related protein; Region: MCE; pfam02470
517417005261	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
517417005262	Beta-lactamase; Region: Beta-lactamase; pfam00144
517417005263	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
517417005264	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
517417005265	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
517417005266	iron-sulfur cluster [ion binding]; other site
517417005267	[2Fe-2S] cluster binding site [ion binding]; other site
517417005268	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
517417005269	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
517417005270	Protein of unknown function (DUF456); Region: DUF456; pfam04306
517417005271	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
517417005272	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
517417005273	purine monophosphate binding site [chemical binding]; other site
517417005274	dimer interface [polypeptide binding]; other site
517417005275	putative catalytic residues [active]
517417005276	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
517417005277	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
517417005278	Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299
517417005279	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
517417005280	active site
517417005281	substrate binding site [chemical binding]; other site
517417005282	cosubstrate binding site; other site
517417005283	catalytic site [active]
517417005284	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
517417005285	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517417005286	FeS/SAM binding site; other site
517417005287	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
517417005288	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
517417005289	Ligand binding site; other site
517417005290	Putative Catalytic site; other site
517417005291	DXD motif; other site
517417005292	endonuclease IV; Provisional; Region: PRK01060
517417005293	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
517417005294	AP (apurinic/apyrimidinic) site pocket; other site
517417005295	DNA interaction; other site
517417005296	Metal-binding active site; metal-binding site
517417005297	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
517417005298	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
517417005299	FtsX-like permease family; Region: FtsX; pfam02687
517417005300	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
517417005301	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
517417005302	active site
517417005303	tetramer interface [polypeptide binding]; other site
517417005304	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
517417005305	active site
517417005306	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
517417005307	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
517417005308	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
517417005309	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
517417005310	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
517417005311	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
517417005312	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
517417005313	active site
517417005314	HIGH motif; other site
517417005315	nucleotide binding site [chemical binding]; other site
517417005316	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
517417005317	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
517417005318	active site
517417005319	KMSKS motif; other site
517417005320	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
517417005321	tRNA binding surface [nucleotide binding]; other site
517417005322	anticodon binding site; other site
517417005323	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
517417005324	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
517417005325	Substrate binding site; other site
517417005326	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
517417005327	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
517417005328	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
517417005329	NAD binding site [chemical binding]; other site
517417005330	substrate binding site [chemical binding]; other site
517417005331	homodimer interface [polypeptide binding]; other site
517417005332	active site
517417005333	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
517417005334	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
517417005335	NADP binding site [chemical binding]; other site
517417005336	active site
517417005337	putative substrate binding site [chemical binding]; other site
517417005338	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
517417005339	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
517417005340	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
517417005341	substrate binding site; other site
517417005342	tetramer interface; other site
517417005343	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
517417005344	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
517417005345	active site
517417005346	catalytic site [active]
517417005347	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
517417005348	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
517417005349	intrachain domain interface; other site
517417005350	interchain domain interface [polypeptide binding]; other site
517417005351	heme bL binding site [chemical binding]; other site
517417005352	heme bH binding site [chemical binding]; other site
517417005353	Qo binding site; other site
517417005354	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
517417005355	interchain domain interface [polypeptide binding]; other site
517417005356	intrachain domain interface; other site
517417005357	Qi binding site; other site
517417005358	Qo binding site; other site
517417005359	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
517417005360	iron-sulfur cluster [ion binding]; other site
517417005361	[2Fe-2S] cluster binding site [ion binding]; other site
517417005362	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
517417005363	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
517417005364	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
517417005365	HIGH motif; other site
517417005366	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
517417005367	active site
517417005368	KMSKS motif; other site
517417005369	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
517417005370	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517417005371	Walker B motif; other site
517417005372	arginine finger; other site
517417005373	Peptidase family M41; Region: Peptidase_M41; pfam01434
517417005374	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
517417005375	IHF dimer interface [polypeptide binding]; other site
517417005376	IHF - DNA interface [nucleotide binding]; other site
517417005377	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
517417005378	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
517417005379	transmembrane helices; other site
517417005380	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
517417005381	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
517417005382	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
517417005383	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517417005384	FeS/SAM binding site; other site
517417005385	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
517417005386	GTPase Era; Reviewed; Region: era; PRK00089
517417005387	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
517417005388	G1 box; other site
517417005389	GTP/Mg2+ binding site [chemical binding]; other site
517417005390	Switch I region; other site
517417005391	G2 box; other site
517417005392	Switch II region; other site
517417005393	G3 box; other site
517417005394	G4 box; other site
517417005395	G5 box; other site
517417005396	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
517417005397	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
517417005398	RNA binding site [nucleotide binding]; other site
517417005399	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
517417005400	RNA binding site [nucleotide binding]; other site
517417005401	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
517417005402	RNA binding site [nucleotide binding]; other site
517417005403	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
517417005404	RNA binding site [nucleotide binding]; other site
517417005405	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
517417005406	RNA binding site [nucleotide binding]; other site
517417005407	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164
517417005408	RNA binding site [nucleotide binding]; other site
517417005409	cytidylate kinase; Provisional; Region: cmk; PRK00023
517417005410	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
517417005411	CMP-binding site; other site
517417005412	The sites determining sugar specificity; other site
517417005413	GTP-binding protein YchF; Reviewed; Region: PRK09601
517417005414	YchF GTPase; Region: YchF; cd01900
517417005415	G1 box; other site
517417005416	GTP/Mg2+ binding site [chemical binding]; other site
517417005417	Switch I region; other site
517417005418	G2 box; other site
517417005419	Switch II region; other site
517417005420	G3 box; other site
517417005421	G4 box; other site
517417005422	G5 box; other site
517417005423	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
517417005424	glutamate racemase; Provisional; Region: PRK00865
517417005425	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
517417005426	LytB protein; Region: LYTB; cl00507
517417005427	putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814
517417005428	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
517417005429	catalytic loop [active]
517417005430	iron binding site [ion binding]; other site
517417005431	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
517417005432	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
517417005433	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
517417005434	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
517417005435	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
517417005436	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
517417005437	active site
517417005438	substrate binding site [chemical binding]; other site
517417005439	metal binding site [ion binding]; metal-binding site
517417005440	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
517417005441	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
517417005442	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
517417005443	DNA binding residues [nucleotide binding]
517417005444	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
517417005445	dimer interface [polypeptide binding]; other site
517417005446	Domain of unknown function (DUF4405); Region: DUF4405; pfam14358
517417005447	Predicted amidohydrolase [General function prediction only]; Region: COG0388
517417005448	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
517417005449	active site
517417005450	catalytic triad [active]
517417005451	dimer interface [polypeptide binding]; other site
517417005452	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
517417005453	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
517417005454	KpsF/GutQ family protein; Region: kpsF; TIGR00393
517417005455	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
517417005456	putative active site [active]
517417005457	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
517417005458	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
517417005459	CoA binding domain; Region: CoA_binding; smart00881
517417005460	CoA-ligase; Region: Ligase_CoA; pfam00549
517417005461	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
517417005462	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
517417005463	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
517417005464	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
517417005465	catalytic residue [active]
517417005466	putative FPP diphosphate  binding site; other site
517417005467	putative FPP binding hydrophobic cleft; other site
517417005468	dimer interface [polypeptide binding]; other site
517417005469	putative IPP diphosphate binding site; other site
517417005470	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
517417005471	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
517417005472	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
517417005473	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
517417005474	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
517417005475	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
517417005476	Surface antigen; Region: Bac_surface_Ag; pfam01103
517417005477	Bifunctional nuclease; Region: DNase-RNase; pfam02577
517417005478	UvrB/uvrC motif; Region: UVR; pfam02151
517417005479	transcription termination factor Rho; Provisional; Region: rho; PRK09376
517417005480	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
517417005481	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
517417005482	RNA binding site [nucleotide binding]; other site
517417005483	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
517417005484	multimer interface [polypeptide binding]; other site
517417005485	Walker A motif; other site
517417005486	ATP binding site [chemical binding]; other site
517417005487	Walker B motif; other site
517417005488	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
517417005489	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
517417005490	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
517417005491	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
517417005492	RuvA N terminal domain; Region: RuvA_N; pfam01330
517417005493	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
517417005494	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
517417005495	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
517417005496	This PGM-like (phosphoglucomutase-like) domain is located C-terminal to a mannose-1-phosphate guanyltransferase domain in a protein of unknown function that is found in both prokaryotes and eukaryotes. This domain belongs to the alpha-D-phosphohexomutase...; Region: PGM_like4; cd05803
517417005497	active site
517417005498	substrate binding site [chemical binding]; other site
517417005499	metal binding site [ion binding]; metal-binding site
517417005500	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
517417005501	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
517417005502	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
517417005503	Walker A/P-loop; other site
517417005504	ATP binding site [chemical binding]; other site
517417005505	Q-loop/lid; other site
517417005506	ABC transporter signature motif; other site
517417005507	Walker B; other site
517417005508	D-loop; other site
517417005509	H-loop/switch region; other site
517417005510	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
517417005511	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
517417005512	FtsX-like permease family; Region: FtsX; pfam02687
517417005513	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
517417005514	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
517417005515	homotetramer interface [polypeptide binding]; other site
517417005516	FMN binding site [chemical binding]; other site
517417005517	homodimer contacts [polypeptide binding]; other site
517417005518	putative active site [active]
517417005519	putative substrate binding site [chemical binding]; other site
517417005520	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
517417005521	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
517417005522	substrate binding pocket [chemical binding]; other site
517417005523	chain length determination region; other site
517417005524	substrate-Mg2+ binding site; other site
517417005525	catalytic residues [active]
517417005526	aspartate-rich region 1; other site
517417005527	active site lid residues [active]
517417005528	aspartate-rich region 2; other site
517417005529	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
517417005530	DNA protecting protein DprA; Region: dprA; TIGR00732
517417005531	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
517417005532	periplasmic chaperone; Provisional; Region: PRK10780
517417005533	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
517417005534	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
517417005535	tetramerization interface [polypeptide binding]; other site
517417005536	active site
517417005537	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
517417005538	Substrate binding site; other site
517417005539	Mg++ binding site; other site
517417005540	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
517417005541	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
517417005542	active site
517417005543	ADP/pyrophosphate binding site [chemical binding]; other site
517417005544	dimerization interface [polypeptide binding]; other site
517417005545	allosteric effector site; other site
517417005546	fructose-1,6-bisphosphate binding site; other site
517417005547	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
517417005548	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
517417005549	active site
517417005550	metal binding site [ion binding]; metal-binding site
517417005551	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
517417005552	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
517417005553	catalytic site [active]
517417005554	G-X2-G-X-G-K; other site
517417005555	hypothetical protein; Provisional; Region: PRK11820
517417005556	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
517417005557	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
517417005558	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
517417005559	16S/18S rRNA binding site [nucleotide binding]; other site
517417005560	S13e-L30e interaction site [polypeptide binding]; other site
517417005561	25S rRNA binding site [nucleotide binding]; other site
517417005562	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
517417005563	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
517417005564	active site
517417005565	Riboflavin kinase; Region: Flavokinase; pfam01687
517417005566	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
517417005567	tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431
517417005568	RNA binding site [nucleotide binding]; other site
517417005569	active site
517417005570	Ribosome-binding factor A; Region: RBFA; pfam02033
517417005571	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
517417005572	translation initiation factor IF-2; Region: IF-2; TIGR00487
517417005573	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
517417005574	G1 box; other site
517417005575	putative GEF interaction site [polypeptide binding]; other site
517417005576	GTP/Mg2+ binding site [chemical binding]; other site
517417005577	Switch I region; other site
517417005578	G2 box; other site
517417005579	G3 box; other site
517417005580	Switch II region; other site
517417005581	G4 box; other site
517417005582	G5 box; other site
517417005583	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
517417005584	Translation-initiation factor 2; Region: IF-2; pfam11987
517417005585	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
517417005586	NusA N-terminal domain; Region: NusA_N; pfam08529
517417005587	transcription termination factor NusA; Region: NusA; TIGR01953
517417005588	NusA-like KH domain; Region: KH_5; pfam13184
517417005589	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
517417005590	G-X-X-G motif; other site
517417005591	hypothetical protein; Provisional; Region: PRK14641
517417005592	Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576
517417005593	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
517417005594	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
517417005595	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
517417005596	dimer interface [polypeptide binding]; other site
517417005597	motif 1; other site
517417005598	active site
517417005599	motif 2; other site
517417005600	motif 3; other site
517417005601	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
517417005602	anticodon binding site; other site
517417005603	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
517417005604	active site
517417005605	phosphorylation site [posttranslational modification]
517417005606	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
517417005607	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
517417005608	CAAX protease self-immunity; Region: Abi; pfam02517
517417005609	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
517417005610	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
517417005611	putative NAD(P) binding site [chemical binding]; other site
517417005612	active site
517417005613	putative substrate binding site [chemical binding]; other site
517417005614	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
517417005615	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
517417005616	putative ADP-binding pocket [chemical binding]; other site
517417005617	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
517417005618	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
517417005619	putative ADP-binding pocket [chemical binding]; other site
517417005620	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
517417005621	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
517417005622	putative ADP-binding pocket [chemical binding]; other site
517417005623	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
517417005624	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
517417005625	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
517417005626	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
517417005627	TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305
517417005628	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
517417005629	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
517417005630	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
517417005631	hypothetical protein; Provisional; Region: PRK10345
517417005632	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
517417005633	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
517417005634	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
517417005635	Walker A/P-loop; other site
517417005636	ATP binding site [chemical binding]; other site
517417005637	Q-loop/lid; other site
517417005638	ABC transporter signature motif; other site
517417005639	Walker B; other site
517417005640	D-loop; other site
517417005641	H-loop/switch region; other site
517417005642	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517417005643	TPR motif; other site
517417005644	binding surface
517417005645	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
517417005646	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
517417005647	active site
517417005648	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
517417005649	Methyltransferase domain; Region: Methyltransf_23; pfam13489
517417005650	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
517417005651	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
517417005652	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
517417005653	active site
517417005654	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
517417005655	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
517417005656	Probable Catalytic site; other site
517417005657	metal-binding site
517417005658	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
517417005659	active site
517417005660	Protein of unknown function (DUF616); Region: DUF616; pfam04765
517417005661	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
517417005662	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
517417005663	putative active site [active]
517417005664	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
517417005665	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
517417005666	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
517417005667	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
517417005668	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
517417005669	active site
517417005670	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
517417005671	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
517417005672	putative acyl-acceptor binding pocket; other site
517417005673	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
517417005674	active site
517417005675	HIGH motif; other site
517417005676	nucleotide binding site [chemical binding]; other site
517417005677	Family of unknown function (DUF490); Region: DUF490; pfam04357
517417005678	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
517417005679	Flavoprotein; Region: Flavoprotein; pfam02441
517417005680	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
517417005681	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
517417005682	Fe-S cluster binding site [ion binding]; other site
517417005683	active site
517417005684	replicative DNA helicase; Region: DnaB; TIGR00665
517417005685	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
517417005686	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
517417005687	Walker A motif; other site
517417005688	ATP binding site [chemical binding]; other site
517417005689	Walker B motif; other site
517417005690	DNA binding loops [nucleotide binding]
517417005691	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
517417005692	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
517417005693	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
517417005694	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
517417005695	SurA N-terminal domain; Region: SurA_N_3; cl07813
517417005696	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
517417005697	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
517417005698	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
517417005699	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
517417005700	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517417005701	S-adenosylmethionine binding site [chemical binding]; other site
517417005702	GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441
517417005703	GIY-YIG motif/motif A; other site
517417005704	putative active site [active]
517417005705	putative metal binding site [ion binding]; other site
517417005706	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
517417005707	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
517417005708	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
517417005709	P loop; other site
517417005710	GTP binding site [chemical binding]; other site
517417005711	thiamine monophosphate kinase; Provisional; Region: PRK05731
517417005712	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
517417005713	ATP binding site [chemical binding]; other site
517417005714	dimerization interface [polypeptide binding]; other site
517417005715	MarR family; Region: MarR_2; cl17246
517417005716	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
517417005717	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
517417005718	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
517417005719	Major Facilitator Superfamily; Region: MFS_1; pfam07690
517417005720	putative substrate translocation pore; other site
517417005721	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
517417005722	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
517417005723	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
517417005724	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
517417005725	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517417005726	dimer interface [polypeptide binding]; other site
517417005727	phosphorylation site [posttranslational modification]
517417005728	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517417005729	ATP binding site [chemical binding]; other site
517417005730	Mg2+ binding site [ion binding]; other site
517417005731	G-X-G motif; other site
517417005732	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
517417005733	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517417005734	active site
517417005735	phosphorylation site [posttranslational modification]
517417005736	intermolecular recognition site; other site
517417005737	dimerization interface [polypeptide binding]; other site
517417005738	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
517417005739	DNA binding site [nucleotide binding]
517417005740	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
517417005741	HEPN domain; Region: HEPN; cl00824
517417005742	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
517417005743	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
517417005744	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
517417005745	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
517417005746	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517417005747	catalytic residue [active]
517417005748	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
517417005749	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
517417005750	Clp amino terminal domain; Region: Clp_N; pfam02861
517417005751	Clp amino terminal domain; Region: Clp_N; pfam02861
517417005752	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517417005753	Walker A motif; other site
517417005754	ATP binding site [chemical binding]; other site
517417005755	Walker B motif; other site
517417005756	arginine finger; other site
517417005757	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517417005758	Walker A motif; other site
517417005759	ATP binding site [chemical binding]; other site
517417005760	Walker B motif; other site
517417005761	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
517417005762	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
517417005763	NADH(P)-binding; Region: NAD_binding_10; pfam13460
517417005764	putative NAD(P) binding site [chemical binding]; other site
517417005765	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517417005766	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
517417005767	FeS/SAM binding site; other site
517417005768	YcaO-like family; Region: YcaO; pfam02624
517417005769	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
517417005770	B12 binding site [chemical binding]; other site
517417005771	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517417005772	Radical SAM superfamily; Region: Radical_SAM; pfam04055
517417005773	FeS/SAM binding site; other site
517417005774	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
517417005775	Cytochrome c [Energy production and conversion]; Region: COG3258
517417005776	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
517417005777	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
517417005778	glycerol kinase; Provisional; Region: glpK; PRK00047
517417005779	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
517417005780	N- and C-terminal domain interface [polypeptide binding]; other site
517417005781	active site
517417005782	MgATP binding site [chemical binding]; other site
517417005783	catalytic site [active]
517417005784	metal binding site [ion binding]; metal-binding site
517417005785	glycerol binding site [chemical binding]; other site
517417005786	homotetramer interface [polypeptide binding]; other site
517417005787	homodimer interface [polypeptide binding]; other site
517417005788	FBP binding site [chemical binding]; other site
517417005789	protein IIAGlc interface [polypeptide binding]; other site
517417005790	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
517417005791	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
517417005792	Walker A/P-loop; other site
517417005793	ATP binding site [chemical binding]; other site
517417005794	Q-loop/lid; other site
517417005795	ABC transporter signature motif; other site
517417005796	Walker B; other site
517417005797	D-loop; other site
517417005798	H-loop/switch region; other site
517417005799	ABC-2 type transporter; Region: ABC2_membrane; cl17235
517417005800	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
517417005801	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
517417005802	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
517417005803	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517417005804	FeS/SAM binding site; other site
517417005805	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
517417005806	C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733
517417005807	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
517417005808	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
517417005809	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
517417005810	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
517417005811	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
517417005812	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
517417005813	Transglycosylase; Region: Transgly; pfam00912
517417005814	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
517417005815	GMP synthase; Reviewed; Region: guaA; PRK00074
517417005816	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
517417005817	AMP/PPi binding site [chemical binding]; other site
517417005818	candidate oxyanion hole; other site
517417005819	catalytic triad [active]
517417005820	potential glutamine specificity residues [chemical binding]; other site
517417005821	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
517417005822	ATP Binding subdomain [chemical binding]; other site
517417005823	Ligand Binding sites [chemical binding]; other site
517417005824	Dimerization subdomain; other site
517417005825	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
517417005826	AAA domain; Region: AAA_30; pfam13604
517417005827	AAA domain; Region: AAA_12; pfam13087
517417005828	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
517417005829	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
517417005830	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
517417005831	phosphoserine phosphatase SerB; Region: serB; TIGR00338
517417005832	Acid Phosphatase; Region: Acid_PPase; cl17256
517417005833	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
517417005834	motif I; other site
517417005835	motif II; other site
517417005836	Ferredoxin [Energy production and conversion]; Region: COG1146
517417005837	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
517417005838	Ferredoxin [Energy production and conversion]; Region: COG1146
517417005839	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
517417005840	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
517417005841	motif 1; other site
517417005842	active site
517417005843	motif 2; other site
517417005844	motif 3; other site
517417005845	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
517417005846	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
517417005847	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
517417005848	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
517417005849	dimer interface [polypeptide binding]; other site
517417005850	PYR/PP interface [polypeptide binding]; other site
517417005851	TPP binding site [chemical binding]; other site
517417005852	substrate binding site [chemical binding]; other site
517417005853	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
517417005854	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
517417005855	TPP-binding site [chemical binding]; other site
517417005856	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
517417005857	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
517417005858	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
517417005859	IHF - DNA interface [nucleotide binding]; other site
517417005860	IHF dimer interface [polypeptide binding]; other site
517417005861	elongation factor P; Validated; Region: PRK00529
517417005862	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
517417005863	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
517417005864	RNA binding site [nucleotide binding]; other site
517417005865	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
517417005866	RNA binding site [nucleotide binding]; other site
517417005867	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
517417005868	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
517417005869	carboxyltransferase (CT) interaction site; other site
517417005870	biotinylation site [posttranslational modification]; other site
517417005871	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
517417005872	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
517417005873	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
517417005874	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
517417005875	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
517417005876	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
517417005877	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
517417005878	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
517417005879	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
517417005880	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
517417005881	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
517417005882	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
517417005883	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
517417005884	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
517417005885	DNA binding site [nucleotide binding]
517417005886	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
517417005887	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
517417005888	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
517417005889	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
517417005890	RPB11 interaction site [polypeptide binding]; other site
517417005891	RPB12 interaction site [polypeptide binding]; other site
517417005892	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
517417005893	RPB12 interaction site [polypeptide binding]; other site
517417005894	RPB3 interaction site [polypeptide binding]; other site
517417005895	RPB1 interaction site [polypeptide binding]; other site
517417005896	RPB11 interaction site [polypeptide binding]; other site
517417005897	RPB10 interaction site [polypeptide binding]; other site
517417005898	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
517417005899	peripheral dimer interface [polypeptide binding]; other site
517417005900	core dimer interface [polypeptide binding]; other site
517417005901	L10 interface [polypeptide binding]; other site
517417005902	L11 interface [polypeptide binding]; other site
517417005903	putative EF-Tu interaction site [polypeptide binding]; other site
517417005904	putative EF-G interaction site [polypeptide binding]; other site
517417005905	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
517417005906	23S rRNA interface [nucleotide binding]; other site
517417005907	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
517417005908	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
517417005909	mRNA/rRNA interface [nucleotide binding]; other site
517417005910	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
517417005911	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
517417005912	23S rRNA interface [nucleotide binding]; other site
517417005913	L7/L12 interface [polypeptide binding]; other site
517417005914	putative thiostrepton binding site; other site
517417005915	L25 interface [polypeptide binding]; other site
517417005916	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
517417005917	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
517417005918	putative homodimer interface [polypeptide binding]; other site
517417005919	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
517417005920	heterodimer interface [polypeptide binding]; other site
517417005921	homodimer interface [polypeptide binding]; other site
517417005922	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
517417005923	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
517417005924	classical (c) SDRs; Region: SDR_c; cd05233
517417005925	NAD(P) binding site [chemical binding]; other site
517417005926	active site
517417005927	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional; Region: PRK02048
517417005928	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
517417005929	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
517417005930	Septum formation initiator; Region: DivIC; pfam04977
517417005931	enolase; Provisional; Region: eno; PRK00077
517417005932	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
517417005933	dimer interface [polypeptide binding]; other site
517417005934	metal binding site [ion binding]; metal-binding site
517417005935	substrate binding pocket [chemical binding]; other site
517417005936	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
517417005937	elongation factor G; Reviewed; Region: PRK12740
517417005938	G1 box; other site
517417005939	putative GEF interaction site [polypeptide binding]; other site
517417005940	GTP/Mg2+ binding site [chemical binding]; other site
517417005941	Switch I region; other site
517417005942	G2 box; other site
517417005943	G3 box; other site
517417005944	Switch II region; other site
517417005945	G4 box; other site
517417005946	G5 box; other site
517417005947	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
517417005948	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
517417005949	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
517417005950	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
517417005951	Ligand binding site; other site
517417005952	Putative Catalytic site; other site
517417005953	DXD motif; other site
517417005954	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
517417005955	Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224
517417005956	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
517417005957	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
517417005958	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
517417005959	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
517417005960	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517417005961	FeS/SAM binding site; other site
517417005962	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
517417005963	putative ligand binding pocket/active site [active]
517417005964	putative metal binding site [ion binding]; other site
517417005965	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
517417005966	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
517417005967	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
517417005968	NAD(P) binding site [chemical binding]; other site
517417005969	Rubredoxin [Energy production and conversion]; Region: COG1773
517417005970	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
517417005971	iron binding site [ion binding]; other site
517417005972	Transglycosylase; Region: Transgly; cl17702
517417005973	Cytochrome c; Region: Cytochrom_C; pfam00034
517417005974	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
517417005975	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517417005976	ATP binding site [chemical binding]; other site
517417005977	Mg2+ binding site [ion binding]; other site
517417005978	G-X-G motif; other site
517417005979	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
517417005980	ATP binding site [chemical binding]; other site
517417005981	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
517417005982	competence damage-inducible protein A; Provisional; Region: PRK00549
517417005983	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
517417005984	putative MPT binding site; other site
517417005985	Competence-damaged protein; Region: CinA; pfam02464
517417005986	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
517417005987	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
517417005988	putative catalytic residues [active]
517417005989	putative nucleotide binding site [chemical binding]; other site
517417005990	putative aspartate binding site [chemical binding]; other site
517417005991	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
517417005992	dimer interface [polypeptide binding]; other site
517417005993	putative threonine allosteric regulatory site; other site
517417005994	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
517417005995	putative threonine allosteric regulatory site; other site
517417005996	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
517417005997	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
517417005998	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
517417005999	core domain interface [polypeptide binding]; other site
517417006000	delta subunit interface [polypeptide binding]; other site
517417006001	epsilon subunit interface [polypeptide binding]; other site
517417006002	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
517417006003	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
517417006004	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
517417006005	beta subunit interaction interface [polypeptide binding]; other site
517417006006	Walker A motif; other site
517417006007	ATP binding site [chemical binding]; other site
517417006008	Walker B motif; other site
517417006009	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
517417006010	homoserine kinase; Provisional; Region: PRK01212
517417006011	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
517417006012	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
517417006013	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
517417006014	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517417006015	catalytic residue [active]
517417006016	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
517417006017	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
517417006018	putative acyl-acceptor binding pocket; other site
517417006019	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
517417006020	homopentamer interface [polypeptide binding]; other site
517417006021	active site
517417006022	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
517417006023	dimer interface [polypeptide binding]; other site
517417006024	active site
517417006025	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
517417006026	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
517417006027	substrate binding site [chemical binding]; other site
517417006028	active site
517417006029	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
517417006030	Cysteine-rich domain; Region: CCG; pfam02754
517417006031	Cysteine-rich domain; Region: CCG; pfam02754
517417006032	Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479
517417006033	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
517417006034	catalytic loop [active]
517417006035	iron binding site [ion binding]; other site
517417006036	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
517417006037	L-aspartate oxidase; Provisional; Region: PRK06175
517417006038	succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812
517417006039	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
517417006040	FOG: CBS domain [General function prediction only]; Region: COG0517
517417006041	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
517417006042	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
517417006043	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
517417006044	Protein export membrane protein; Region: SecD_SecF; cl14618
517417006045	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
517417006046	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
517417006047	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
517417006048	putative homodimer interface [polypeptide binding]; other site
517417006049	putative homotetramer interface [polypeptide binding]; other site
517417006050	putative allosteric switch controlling residues; other site
517417006051	putative metal binding site [ion binding]; other site
517417006052	putative homodimer-homodimer interface [polypeptide binding]; other site
517417006053	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
517417006054	Phosphotransferase enzyme family; Region: APH; pfam01636
517417006055	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
517417006056	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
517417006057	Substrate binding site; other site
517417006058	metal-binding site
517417006059	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
517417006060	N-terminal domain interface [polypeptide binding]; other site
517417006061	sulfate 1 binding site; other site
517417006062	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
517417006063	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493
517417006064	Na binding site [ion binding]; other site
517417006065	Response regulator receiver domain; Region: Response_reg; pfam00072
517417006066	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517417006067	active site
517417006068	phosphorylation site [posttranslational modification]
517417006069	intermolecular recognition site; other site
517417006070	dimerization interface [polypeptide binding]; other site
517417006071	PAS domain S-box; Region: sensory_box; TIGR00229
517417006072	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
517417006073	dimer interface [polypeptide binding]; other site
517417006074	phosphorylation site [posttranslational modification]
517417006075	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
517417006076	ATP binding site [chemical binding]; other site
517417006077	Mg2+ binding site [ion binding]; other site
517417006078	G-X-G motif; other site
517417006079	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
517417006080	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517417006081	active site
517417006082	phosphorylation site [posttranslational modification]
517417006083	intermolecular recognition site; other site
517417006084	dimerization interface [polypeptide binding]; other site
517417006085	Response regulator receiver domain; Region: Response_reg; pfam00072
517417006086	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517417006087	active site
517417006088	phosphorylation site [posttranslational modification]
517417006089	intermolecular recognition site; other site
517417006090	dimerization interface [polypeptide binding]; other site
517417006091	Bacteriochlorophyll C binding protein; Region: Bac_chlorC; pfam02043
517417006092	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
517417006093	NADH(P)-binding; Region: NAD_binding_10; pfam13460
517417006094	NAD(P) binding site [chemical binding]; other site
517417006095	putative active site [active]
517417006096	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
517417006097	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
517417006098	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
517417006099	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
517417006100	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
517417006101	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
517417006102	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
517417006103	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
517417006104	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
517417006105	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
517417006106	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
517417006107	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
517417006108	P loop; other site
517417006109	Nucleotide binding site [chemical binding]; other site
517417006110	DTAP/Switch II; other site
517417006111	Switch I; other site
517417006112	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
517417006113	putative active site [active]
517417006114	heme pocket [chemical binding]; other site
517417006115	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
517417006116	potassium uptake protein; Region: kup; TIGR00794
517417006117	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
517417006118	potassium uptake protein; Region: kup; TIGR00794
517417006119	TPR repeat; Region: TPR_11; pfam13414
517417006120	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517417006121	binding surface
517417006122	TPR motif; other site
517417006123	TPR repeat; Region: TPR_11; pfam13414
517417006124	TPR repeat; Region: TPR_11; pfam13414
517417006125	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
517417006126	binding surface
517417006127	TPR motif; other site
517417006128	Tetratricopeptide repeat; Region: TPR_16; pfam13432
517417006129	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
517417006130	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
517417006131	Polymerase and Histidinol Phosphatase domain of Thermotoga like; Region: PHP_HisPPase_Thermotoga_like; cd12111
517417006132	PHP domain; Region: PHP; pfam02811
517417006133	active site
517417006134	dimer interface [polypeptide binding]; other site
517417006135	Methyltransferase domain; Region: Methyltransf_23; pfam13489
517417006136	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517417006137	S-adenosylmethionine binding site [chemical binding]; other site
517417006138	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547
517417006139	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
517417006140	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_1; cd03400
517417006141	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
517417006142	GIY-YIG motif/motif A; other site
517417006143	putative active site [active]
517417006144	putative metal binding site [ion binding]; other site
517417006145	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
517417006146	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
517417006147	trmE is a tRNA modification GTPase; Region: trmE; cd04164
517417006148	G1 box; other site
517417006149	GTP/Mg2+ binding site [chemical binding]; other site
517417006150	Switch I region; other site
517417006151	G2 box; other site
517417006152	Switch II region; other site
517417006153	G3 box; other site
517417006154	G4 box; other site
517417006155	G5 box; other site
517417006156	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
517417006157	short chain dehydrogenase; Provisional; Region: PRK07326
517417006158	classical (c) SDRs; Region: SDR_c; cd05233
517417006159	NAD(P) binding site [chemical binding]; other site
517417006160	active site
517417006161	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
517417006162	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
517417006163	homodimer interface [polypeptide binding]; other site
517417006164	metal binding site [ion binding]; metal-binding site
517417006165	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
517417006166	homodimer interface [polypeptide binding]; other site
517417006167	active site
517417006168	putative chemical substrate binding site [chemical binding]; other site
517417006169	metal binding site [ion binding]; metal-binding site
517417006170	Predicted esterase [General function prediction only]; Region: COG0400
517417006171	Serine hydrolase (FSH1); Region: FSH1; pfam03959
517417006172	trehalose synthase; Region: treS_nterm; TIGR02456
517417006173	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
517417006174	active site
517417006175	catalytic site [active]
517417006176	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
517417006177	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
517417006178	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
517417006179	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
517417006180	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
517417006181	active site
517417006182	homodimer interface [polypeptide binding]; other site
517417006183	catalytic site [active]
517417006184	acceptor binding site [chemical binding]; other site
517417006185	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
517417006186	Homo sapiens Nbla03831 and related proteins, metallophosphatase domain; Region: MPP_Nbla03831; cd07396
517417006187	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
517417006188	active site
517417006189	metal binding site [ion binding]; metal-binding site
517417006190	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
517417006191	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
517417006192	active site
517417006193	phosphorylation site [posttranslational modification]
517417006194	intermolecular recognition site; other site
517417006195	dimerization interface [polypeptide binding]; other site
517417006196	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
517417006197	DNA binding site [nucleotide binding]
517417006198	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
517417006199	homodimer interface [polypeptide binding]; other site
517417006200	active site
517417006201	OstA-like protein; Region: OstA_2; pfam13100
517417006202	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934
517417006203	Clp amino terminal domain; Region: Clp_N; pfam02861
517417006204	Clp amino terminal domain; Region: Clp_N; pfam02861
517417006205	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517417006206	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
517417006207	Walker A motif; other site
517417006208	ATP binding site [chemical binding]; other site
517417006209	Walker B motif; other site
517417006210	arginine finger; other site
517417006211	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
517417006212	UGMP family protein; Validated; Region: PRK09604
517417006213	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
517417006214	Preprotein translocase subunit; Region: YajC; pfam02699
517417006215	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
517417006216	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
517417006217	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
517417006218	catalytic site [active]
517417006219	subunit interface [polypeptide binding]; other site
517417006220	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
517417006221	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
517417006222	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
517417006223	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
517417006224	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
517417006225	catalytic residue [active]
517417006226	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
517417006227	B12 binding site [chemical binding]; other site
517417006228	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
517417006229	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517417006230	FeS/SAM binding site; other site
517417006231	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
517417006232	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
517417006233	Uncharacterized conserved protein [Function unknown]; Region: COG4095
517417006234	pyrroline-5-carboxylate reductase; Region: PLN02688
517417006235	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
517417006236	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
517417006237	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
517417006238	active site
517417006239	catalytic site [active]
517417006240	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
517417006241	Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; pfam10137
517417006242	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
517417006243	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
517417006244	active site
517417006245	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
517417006246	prephenate dehydrogenase; Validated; Region: PRK08507
517417006247	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
517417006248	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
517417006249	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
517417006250	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
517417006251	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
517417006252	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
517417006253	Walker A motif; other site
517417006254	ATP binding site [chemical binding]; other site
517417006255	Walker B motif; other site
517417006256	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
517417006257	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
517417006258	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
517417006259	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
517417006260	catalytic core [active]
517417006261	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
517417006262	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
517417006263	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
517417006264	membrane protein; Provisional; Region: PRK14410
517417006265	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
517417006266	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
517417006267	dimerization interface [polypeptide binding]; other site
517417006268	putative ATP binding site [chemical binding]; other site
517417006269	aspartate kinase III; Validated; Region: PRK09084
517417006270	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
517417006271	nucleotide binding site [chemical binding]; other site
517417006272	substrate binding site [chemical binding]; other site
517417006273	ACT domains located C-terminal to the catalytic domain of  the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912
517417006274	dimer interface [polypeptide binding]; other site
517417006275	allosteric regulatory binding pocket; other site
517417006276	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
517417006277	outer membrane lipoprotein; Provisional; Region: spr; PRK10838
517417006278	NlpC/P60 family; Region: NLPC_P60; pfam00877
517417006279	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
517417006280	Methyltransferase domain; Region: Methyltransf_18; pfam12847
517417006281	exopolyphosphatase; Region: exo_poly_only; TIGR03706
517417006282	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
517417006283	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
517417006284	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
517417006285	acyl-activating enzyme (AAE) consensus motif; other site
517417006286	putative AMP binding site [chemical binding]; other site
517417006287	putative active site [active]
517417006288	putative CoA binding site [chemical binding]; other site
517417006289	adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986
517417006290	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
517417006291	inhibitor-cofactor binding pocket; inhibition site
517417006292	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517417006293	catalytic residue [active]
517417006294	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
517417006295	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
517417006296	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517417006297	S-adenosylmethionine binding site [chemical binding]; other site
517417006298	Protein of unknown function (DUF452); Region: DUF452; cl01062
517417006299	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
517417006300	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
517417006301	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
517417006302	substrate-cofactor binding pocket; other site
517417006303	pyridoxal 5'-phosphate binding site [chemical binding]; other site
517417006304	catalytic residue [active]
517417006305	biotin synthase; Region: bioB; TIGR00433
517417006306	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517417006307	FeS/SAM binding site; other site
517417006308	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
517417006309	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
517417006310	putative DNA binding site [nucleotide binding]; other site
517417006311	putative Zn2+ binding site [ion binding]; other site
517417006312	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
517417006313	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
517417006314	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
517417006315	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
517417006316	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
517417006317	active site
517417006318	metal binding site [ion binding]; metal-binding site
517417006319	DNA topoisomerase I; Validated; Region: PRK06599
517417006320	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
517417006321	active site
517417006322	interdomain interaction site; other site
517417006323	putative metal-binding site [ion binding]; other site
517417006324	nucleotide binding site [chemical binding]; other site
517417006325	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
517417006326	domain I; other site
517417006327	DNA binding groove [nucleotide binding]
517417006328	phosphate binding site [ion binding]; other site
517417006329	domain II; other site
517417006330	domain III; other site
517417006331	nucleotide binding site [chemical binding]; other site
517417006332	catalytic site [active]
517417006333	domain IV; other site
517417006334	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
517417006335	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
517417006336	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
517417006337	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
517417006338	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
517417006339	G1 box; other site
517417006340	GTP/Mg2+ binding site [chemical binding]; other site
517417006341	Switch I region; other site
517417006342	G2 box; other site
517417006343	G3 box; other site
517417006344	Switch II region; other site
517417006345	G4 box; other site
517417006346	G5 box; other site
517417006347	Nucleoside recognition; Region: Gate; pfam07670
517417006348	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
517417006349	Nucleoside recognition; Region: Gate; pfam07670
517417006350	FeoA domain; Region: FeoA; pfam04023
517417006351	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
517417006352	nucleotide binding site/active site [active]
517417006353	HIT family signature motif; other site
517417006354	catalytic residue [active]
517417006355	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; pfam09603
517417006356	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
517417006357	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
517417006358	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
517417006359	L-aspartate oxidase; Provisional; Region: PRK06175
517417006360	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
517417006361	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
517417006362	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
517417006363	putative Iron-sulfur protein interface [polypeptide binding]; other site
517417006364	proximal heme binding site [chemical binding]; other site
517417006365	distal heme binding site [chemical binding]; other site
517417006366	putative dimer interface [polypeptide binding]; other site
517417006367	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
517417006368	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
517417006369	PGAP1-like protein; Region: PGAP1; pfam07819
517417006370	Esterase/lipase [General function prediction only]; Region: COG1647
517417006371	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
517417006372	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
517417006373	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
517417006374	Coenzyme A binding pocket [chemical binding]; other site
517417006375	Protein of unknown function DUF89; Region: DUF89; cl15397
517417006376	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
517417006377	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
517417006378	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
517417006379	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
517417006380	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517417006381	S-adenosylmethionine binding site [chemical binding]; other site
517417006382	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
517417006383	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
517417006384	FeS/SAM binding site; other site
517417006385	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
517417006386	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
517417006387	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
517417006388	META domain; Region: META; pfam03724
517417006389	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
517417006390	active site
517417006391	intersubunit interactions; other site
517417006392	catalytic residue [active]
517417006393	deoxyhypusine synthase-like protein; Provisional; Region: PRK02492
517417006394	deoxyhypusine synthase; Region: dhys; TIGR00321
517417006395	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
517417006396	active site
517417006397	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
517417006398	HIGH motif; other site
517417006399	dimer interface [polypeptide binding]; other site
517417006400	KMSKS motif; other site
517417006401	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
517417006402	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
517417006403	motif II; other site
517417006404	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
517417006405	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
517417006406	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
517417006407	active site
517417006408	HIGH motif; other site
517417006409	KMSK motif region; other site
517417006410	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
517417006411	tRNA binding surface [nucleotide binding]; other site
517417006412	anticodon binding site; other site
517417006413	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
517417006414	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
517417006415	active site
517417006416	(T/H)XGH motif; other site
517417006417	Prp18 domain; Region: Prp18; pfam02840
517417006418	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
517417006419	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
517417006420	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
517417006421	F0F1 ATP synthase subunit B; Provisional; Region: PRK14472
517417006422	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
517417006423	ATP synthase subunit C; Region: ATP-synt_C; cl00466
517417006424	F0F1 ATP synthase subunit A; Provisional; Region: PRK13419
517417006425	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
517417006426	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
517417006427	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
517417006428	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
517417006429	NAD binding site [chemical binding]; other site
517417006430	homodimer interface [polypeptide binding]; other site
517417006431	active site
517417006432	substrate binding site [chemical binding]; other site
517417006433	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
517417006434	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
517417006435	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
517417006436	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
517417006437	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
517417006438	cell division protein FtsZ; Validated; Region: PRK09330
517417006439	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
517417006440	nucleotide binding site [chemical binding]; other site
517417006441	SulA interaction site; other site
517417006442	cell division protein FtsA; Region: ftsA; TIGR01174
517417006443	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
517417006444	nucleotide binding site [chemical binding]; other site
517417006445	Cell division protein FtsA; Region: FtsA; pfam14450
517417006446	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
517417006447	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
517417006448	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
517417006449	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
517417006450	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
517417006451	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
517417006452	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
517417006453	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
517417006454	active site
517417006455	homodimer interface [polypeptide binding]; other site
517417006456	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
517417006457	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106
517417006458	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
517417006459	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
517417006460	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
517417006461	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
517417006462	Mg++ binding site [ion binding]; other site
517417006463	putative catalytic motif [active]
517417006464	putative substrate binding site [chemical binding]; other site
517417006465	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
517417006466	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
517417006467	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
517417006468	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
517417006469	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
517417006470	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
517417006471	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
517417006472	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
517417006473	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
517417006474	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
517417006475	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
517417006476	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
517417006477	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
517417006478	MraW methylase family; Region: Methyltransf_5; cl17771
517417006479	cell division protein MraZ; Reviewed; Region: PRK00326
517417006480	MraZ protein; Region: MraZ; pfam02381
517417006481	MraZ protein; Region: MraZ; pfam02381
517417006482	YacP-like NYN domain; Region: NYN_YacP; pfam05991
517417006483	Chorismate mutase type II; Region: CM_2; pfam01817
517417006484	YceG-like family; Region: YceG; pfam02618
517417006485	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
517417006486	dimerization interface [polypeptide binding]; other site
517417006487	Phosphoglycerate kinase; Region: PGK; pfam00162
517417006488	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
517417006489	substrate binding site [chemical binding]; other site
517417006490	hinge regions; other site
517417006491	ADP binding site [chemical binding]; other site
517417006492	catalytic site [active]
517417006493	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
517417006494	Uncharacterized conserved protein [Function unknown]; Region: COG3339
517417006495	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
517417006496	putative ADP-ribose binding site [chemical binding]; other site
517417006497	putative active site [active]
517417006498	TRAM domain; Region: TRAM; cl01282
517417006499	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
517417006500	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
517417006501	S-adenosylmethionine binding site [chemical binding]; other site
517417006502	PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395
517417006503	active site
517417006504	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
517417006505	membrane protein insertase; Provisional; Region: PRK01318
517417006506	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
517417006507	Haemolytic domain; Region: Haemolytic; pfam01809
517417006508	ribonuclease P; Reviewed; Region: rnpA; PRK01903