-- dump date 20140619_041042 -- class Genbank::misc_feature -- table misc_feature_note -- id note 290315000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 290315000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 290315000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290315000004 Walker A motif; other site 290315000005 ATP binding site [chemical binding]; other site 290315000006 Walker B motif; other site 290315000007 arginine finger; other site 290315000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 290315000009 DnaA box-binding interface [nucleotide binding]; other site 290315000010 DNA polymerase III subunit beta; Provisional; Region: PRK14941 290315000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 290315000012 putative DNA binding surface [nucleotide binding]; other site 290315000013 dimer interface [polypeptide binding]; other site 290315000014 beta-clamp/clamp loader binding surface; other site 290315000015 beta-clamp/translesion DNA polymerase binding surface; other site 290315000016 recombination protein F; Reviewed; Region: recF; PRK00064 290315000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290315000018 Walker A/P-loop; other site 290315000019 ATP binding site [chemical binding]; other site 290315000020 Q-loop/lid; other site 290315000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290315000022 ABC transporter signature motif; other site 290315000023 Walker B; other site 290315000024 D-loop; other site 290315000025 H-loop/switch region; other site 290315000026 Protein of unknown function (DUF721); Region: DUF721; pfam05258 290315000027 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 290315000028 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 290315000029 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 290315000030 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like2_exo; cd05785 290315000031 DNA polymerase type-B family; Region: POLBc; smart00486 290315000032 active site 290315000033 catalytic site [active] 290315000034 substrate binding site [chemical binding]; other site 290315000035 DNA polymerase type-II B subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II_B; cd05538 290315000036 active site 290315000037 metal-binding site 290315000038 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 290315000039 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290315000040 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 290315000041 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 290315000042 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 290315000043 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 290315000044 Cytochrome c; Region: Cytochrom_C; cl11414 290315000045 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 290315000046 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 290315000047 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290315000048 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 290315000049 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 290315000050 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 290315000051 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 290315000052 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 290315000053 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 290315000054 Protein export membrane protein; Region: SecD_SecF; pfam02355 290315000055 SurA N-terminal domain; Region: SurA_N; pfam09312 290315000056 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 290315000057 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 290315000058 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 290315000059 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290315000060 ATP binding site [chemical binding]; other site 290315000061 Mg2+ binding site [ion binding]; other site 290315000062 G-X-G motif; other site 290315000063 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 290315000064 anchoring element; other site 290315000065 dimer interface [polypeptide binding]; other site 290315000066 ATP binding site [chemical binding]; other site 290315000067 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 290315000068 active site 290315000069 putative metal-binding site [ion binding]; other site 290315000070 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 290315000071 hypothetical protein; Reviewed; Region: PRK12497 290315000072 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 290315000073 RNA/DNA hybrid binding site [nucleotide binding]; other site 290315000074 active site 290315000075 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 290315000076 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 290315000077 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 290315000078 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 290315000079 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 290315000080 trimer interface [polypeptide binding]; other site 290315000081 active site 290315000082 substrate binding site [chemical binding]; other site 290315000083 CoA binding site [chemical binding]; other site 290315000084 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 290315000085 C-terminal peptidase (prc); Region: prc; TIGR00225 290315000086 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 290315000087 protein binding site [polypeptide binding]; other site 290315000088 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 290315000089 Catalytic dyad [active] 290315000090 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 290315000091 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 290315000092 geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023 290315000093 glycyl-tRNA synthetase; Provisional; Region: PRK04173 290315000094 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 290315000095 motif 1; other site 290315000096 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 290315000097 active site 290315000098 motif 2; other site 290315000099 motif 3; other site 290315000100 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 290315000101 anticodon binding site; other site 290315000102 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 290315000103 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 290315000104 dimer interface [polypeptide binding]; other site 290315000105 catalytic triad [active] 290315000106 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 290315000107 gamma subunit interface [polypeptide binding]; other site 290315000108 epsilon subunit interface [polypeptide binding]; other site 290315000109 LBP interface [polypeptide binding]; other site 290315000110 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 290315000111 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 290315000112 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 290315000113 alpha subunit interaction interface [polypeptide binding]; other site 290315000114 Walker A motif; other site 290315000115 ATP binding site [chemical binding]; other site 290315000116 Walker B motif; other site 290315000117 inhibitor binding site; inhibition site 290315000118 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 290315000119 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 290315000120 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 290315000121 catalytic residues [active] 290315000122 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 290315000123 active site 290315000124 substrate-binding site [chemical binding]; other site 290315000125 metal-binding site [ion binding] 290315000126 GTP binding site [chemical binding]; other site 290315000127 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 290315000128 Dodecin; Region: Dodecin; pfam07311 290315000129 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 290315000130 4Fe-4S binding domain; Region: Fer4; pfam00037 290315000131 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 290315000132 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 290315000133 molybdopterin cofactor binding site; other site 290315000134 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 290315000135 putative molybdopterin cofactor binding site; other site 290315000136 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 290315000137 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 290315000138 CPxP motif; other site 290315000139 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 290315000140 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 290315000141 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290315000142 ATP binding site [chemical binding]; other site 290315000143 putative Mg++ binding site [ion binding]; other site 290315000144 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290315000145 nucleotide binding region [chemical binding]; other site 290315000146 ATP-binding site [chemical binding]; other site 290315000147 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 290315000148 HRDC domain; Region: HRDC; pfam00570 290315000149 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290315000150 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290315000151 WHG domain; Region: WHG; pfam13305 290315000152 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 290315000153 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 290315000154 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 290315000155 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 290315000156 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 290315000157 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290315000158 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290315000159 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290315000160 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 290315000161 DNA methylase; Region: N6_N4_Mtase; pfam01555 290315000162 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 290315000163 Catalytic site; other site 290315000164 MjaI restriction endonuclease; Region: RE_MjaI; pfam09568 290315000165 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 290315000166 Uncharacterized conserved protein [Function unknown]; Region: COG3410 290315000167 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 290315000168 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 290315000169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290315000170 H+ Antiporter protein; Region: 2A0121; TIGR00900 290315000171 putative substrate translocation pore; other site 290315000172 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 290315000173 SelR domain; Region: SelR; pfam01641 290315000174 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 290315000175 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 290315000176 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 290315000177 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290315000178 putative substrate translocation pore; other site 290315000179 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290315000180 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 290315000181 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 290315000182 HlyD family secretion protein; Region: HlyD_3; pfam13437 290315000183 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290315000184 Ligand Binding Site [chemical binding]; other site 290315000185 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 290315000186 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 290315000187 GAF domain; Region: GAF_3; pfam13492 290315000188 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290315000189 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 290315000190 Walker A motif; other site 290315000191 ATP binding site [chemical binding]; other site 290315000192 Walker B motif; other site 290315000193 arginine finger; other site 290315000194 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 290315000195 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290315000196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290315000197 homodimer interface [polypeptide binding]; other site 290315000198 catalytic residue [active] 290315000199 ACT domain-containing protein [General function prediction only]; Region: COG4747 290315000200 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 290315000201 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 290315000202 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 290315000203 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 290315000204 acyl-activating enzyme (AAE) consensus motif; other site 290315000205 AMP binding site [chemical binding]; other site 290315000206 active site 290315000207 CoA binding site [chemical binding]; other site 290315000208 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 290315000209 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 290315000210 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 290315000211 dimer interface [polypeptide binding]; other site 290315000212 PYR/PP interface [polypeptide binding]; other site 290315000213 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 290315000214 TPP binding site [chemical binding]; other site 290315000215 substrate binding site [chemical binding]; other site 290315000216 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 290315000217 TPP-binding site; other site 290315000218 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 290315000219 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 290315000220 P loop; other site 290315000221 Nucleotide binding site [chemical binding]; other site 290315000222 DTAP/Switch II; other site 290315000223 Switch I; other site 290315000224 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 290315000225 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 290315000226 Esterase/lipase [General function prediction only]; Region: COG1647 290315000227 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139 290315000228 putative FMN binding site [chemical binding]; other site 290315000229 peptide chain release factor 1; Validated; Region: prfA; PRK00591 290315000230 PCRF domain; Region: PCRF; pfam03462 290315000231 RF-1 domain; Region: RF-1; pfam00472 290315000232 RIP metalloprotease RseP; Region: TIGR00054 290315000233 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 290315000234 active site 290315000235 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 290315000236 protein binding site [polypeptide binding]; other site 290315000237 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 290315000238 protein binding site [polypeptide binding]; other site 290315000239 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 290315000240 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 290315000241 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 290315000242 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 290315000243 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 290315000244 acylphosphatase; Provisional; Region: PRK14445 290315000245 FtsH Extracellular; Region: FtsH_ext; pfam06480 290315000246 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 290315000247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290315000248 Walker B motif; other site 290315000249 arginine finger; other site 290315000250 Peptidase family M41; Region: Peptidase_M41; pfam01434 290315000251 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 290315000252 active site 290315000253 dimer interface [polypeptide binding]; other site 290315000254 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 290315000255 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 290315000256 glutaminase active site [active] 290315000257 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 290315000258 dimer interface [polypeptide binding]; other site 290315000259 active site 290315000260 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 290315000261 dimer interface [polypeptide binding]; other site 290315000262 active site 290315000263 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 290315000264 TIGR01777 family protein; Region: yfcH 290315000265 putative NAD(P) binding site [chemical binding]; other site 290315000266 putative active site [active] 290315000267 DPS-like protein, ferritin-like diiron-binding domain; Region: DPSL; cd01052 290315000268 Ferritin-like domain; Region: Ferritin; pfam00210 290315000269 diiron binding motif [ion binding]; other site 290315000270 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 290315000271 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 290315000272 Nitrogen regulatory protein P-II; Region: P-II; smart00938 290315000273 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 290315000274 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290315000275 binding surface 290315000276 TPR repeat; Region: TPR_11; pfam13414 290315000277 TPR motif; other site 290315000278 TPR repeat; Region: TPR_11; pfam13414 290315000279 ScpA/B protein; Region: ScpA_ScpB; cl00598 290315000280 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 290315000281 putative dimer interface [polypeptide binding]; other site 290315000282 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290315000283 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 290315000284 Uncharacterized conserved protein [Function unknown]; Region: COG4198 290315000285 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 290315000286 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 290315000287 Glycoprotease family; Region: Peptidase_M22; pfam00814 290315000288 Oligomerisation domain; Region: Oligomerisation; pfam02410 290315000289 DNA gyrase subunit A; Validated; Region: PRK05560 290315000290 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 290315000291 CAP-like domain; other site 290315000292 active site 290315000293 primary dimer interface [polypeptide binding]; other site 290315000294 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290315000295 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290315000296 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290315000297 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290315000298 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290315000299 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 290315000300 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 290315000301 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 290315000302 CTP synthetase; Validated; Region: pyrG; PRK05380 290315000303 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 290315000304 Catalytic site [active] 290315000305 active site 290315000306 UTP binding site [chemical binding]; other site 290315000307 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 290315000308 active site 290315000309 putative oxyanion hole; other site 290315000310 catalytic triad [active] 290315000311 RES domain; Region: RES; smart00953 290315000312 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 290315000313 HipA N-terminal domain; Region: Couple_hipA; pfam13657 290315000314 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 290315000315 HipA-like N-terminal domain; Region: HipA_N; pfam07805 290315000316 HipA-like C-terminal domain; Region: HipA_C; pfam07804 290315000317 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290315000318 non-specific DNA binding site [nucleotide binding]; other site 290315000319 salt bridge; other site 290315000320 sequence-specific DNA binding site [nucleotide binding]; other site 290315000321 Predicted transcriptional regulator [Transcription]; Region: COG3905 290315000322 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 290315000323 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 290315000324 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 290315000325 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290315000326 Walker A motif; other site 290315000327 ATP binding site [chemical binding]; other site 290315000328 Walker B motif; other site 290315000329 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290315000330 AAA domain; Region: AAA_22; pfam13401 290315000331 ATP binding site [chemical binding]; other site 290315000332 Walker A motif; other site 290315000333 Walker B motif; other site 290315000334 arginine finger; other site 290315000335 ORF6N domain; Region: ORF6N; pfam10543 290315000336 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290315000337 AAA domain; Region: AAA_23; pfam13476 290315000338 Walker A/P-loop; other site 290315000339 ATP binding site [chemical binding]; other site 290315000340 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290315000341 ABC transporter signature motif; other site 290315000342 Walker B; other site 290315000343 D-loop; other site 290315000344 H-loop/switch region; other site 290315000345 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 290315000346 Methyltransferase domain; Region: Methyltransf_26; pfam13659 290315000347 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 290315000348 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 290315000349 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 290315000350 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 290315000351 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290315000352 putative Mg++ binding site [ion binding]; other site 290315000353 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290315000354 dimerization interface [polypeptide binding]; other site 290315000355 putative DNA binding site [nucleotide binding]; other site 290315000356 putative Zn2+ binding site [ion binding]; other site 290315000357 Predicted permeases [General function prediction only]; Region: COG0701 290315000358 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 290315000359 PHP domain; Region: PHP; pfam02811 290315000360 active site 290315000361 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 290315000362 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 290315000363 dimer interface [polypeptide binding]; other site 290315000364 active site 290315000365 heme binding site [chemical binding]; other site 290315000366 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 290315000367 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 290315000368 metal binding site 2 [ion binding]; metal-binding site 290315000369 putative DNA binding helix; other site 290315000370 metal binding site 1 [ion binding]; metal-binding site 290315000371 dimer interface [polypeptide binding]; other site 290315000372 structural Zn2+ binding site [ion binding]; other site 290315000373 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 290315000374 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 290315000375 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290315000376 FeS/SAM binding site; other site 290315000377 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 290315000378 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290315000379 motif II; other site 290315000380 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 290315000381 N- and C-terminal domain interface [polypeptide binding]; other site 290315000382 glycerol kinase; Provisional; Region: glpK; PRK00047 290315000383 active site 290315000384 MgATP binding site [chemical binding]; other site 290315000385 catalytic site [active] 290315000386 metal binding site [ion binding]; metal-binding site 290315000387 glycerol binding site [chemical binding]; other site 290315000388 homotetramer interface [polypeptide binding]; other site 290315000389 homodimer interface [polypeptide binding]; other site 290315000390 FBP binding site [chemical binding]; other site 290315000391 protein IIAGlc interface [polypeptide binding]; other site 290315000392 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 290315000393 active site 290315000394 Domain of Unknown Function (DUF3856); Region: DUF3856; pfam12968 290315000395 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 290315000396 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 290315000397 putative active site [active] 290315000398 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 290315000399 putative catalytic site [active] 290315000400 putative metal binding site [ion binding]; other site 290315000401 putative phosphate binding site [ion binding]; other site 290315000402 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 290315000403 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 290315000404 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 290315000405 dimer interface [polypeptide binding]; other site 290315000406 ssDNA binding site [nucleotide binding]; other site 290315000407 tetramer (dimer of dimers) interface [polypeptide binding]; other site 290315000408 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 290315000409 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 290315000410 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 290315000411 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 290315000412 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 290315000413 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 290315000414 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 290315000415 dimer interface [polypeptide binding]; other site 290315000416 motif 1; other site 290315000417 active site 290315000418 motif 2; other site 290315000419 motif 3; other site 290315000420 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 290315000421 23S rRNA binding site [nucleotide binding]; other site 290315000422 L21 binding site [polypeptide binding]; other site 290315000423 L13 binding site [polypeptide binding]; other site 290315000424 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 290315000425 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 290315000426 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 290315000427 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 290315000428 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 290315000429 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 290315000430 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 290315000431 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 290315000432 active site 290315000433 dimer interface [polypeptide binding]; other site 290315000434 motif 1; other site 290315000435 motif 2; other site 290315000436 motif 3; other site 290315000437 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 290315000438 anticodon binding site; other site 290315000439 Chlide_reductase_Z : Z subunit of chlorophyllide (chlide) reductase (BchZ). Chlide reductase participates in photosynthetic pigment synthesis playing a role in the conversion of chlorophylls(Chl) into bacteriochlorophylls (BChl). Chlide reductase...; Region: Chlide_reductase_Z; cd01982 290315000440 chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014 290315000441 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 290315000442 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 290315000443 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 290315000444 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 290315000445 active site 290315000446 homodimer interface [polypeptide binding]; other site 290315000447 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 290315000448 active site 290315000449 Zn binding site [ion binding]; other site 290315000450 Transposase [DNA replication, recombination, and repair]; Region: COG5421 290315000451 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 290315000452 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290315000453 active site 290315000454 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 290315000455 tetramer interface [polypeptide binding]; other site 290315000456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290315000457 catalytic residue [active] 290315000458 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 290315000459 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 290315000460 dimerization interface [polypeptide binding]; other site 290315000461 active site 290315000462 metal binding site [ion binding]; metal-binding site 290315000463 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 290315000464 dsRNA binding site [nucleotide binding]; other site 290315000465 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 290315000466 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 290315000467 dimer interface [polypeptide binding]; other site 290315000468 active site 290315000469 acyl carrier protein; Provisional; Region: acpP; PRK00982 290315000470 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 290315000471 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 290315000472 NAD(P) binding site [chemical binding]; other site 290315000473 homotetramer interface [polypeptide binding]; other site 290315000474 homodimer interface [polypeptide binding]; other site 290315000475 active site 290315000476 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 290315000477 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 290315000478 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 290315000479 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 290315000480 dimer interface [polypeptide binding]; other site 290315000481 active site 290315000482 CoA binding pocket [chemical binding]; other site 290315000483 putative phosphate acyltransferase; Provisional; Region: PRK05331 290315000484 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 290315000485 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 290315000486 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 290315000487 active site 290315000488 Response regulator receiver domain; Region: Response_reg; pfam00072 290315000489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290315000490 active site 290315000491 phosphorylation site [posttranslational modification] 290315000492 intermolecular recognition site; other site 290315000493 dimerization interface [polypeptide binding]; other site 290315000494 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290315000495 PAS domain; Region: PAS_9; pfam13426 290315000496 putative active site [active] 290315000497 heme pocket [chemical binding]; other site 290315000498 PAS domain S-box; Region: sensory_box; TIGR00229 290315000499 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290315000500 putative active site [active] 290315000501 heme pocket [chemical binding]; other site 290315000502 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290315000503 PAS domain; Region: PAS_9; pfam13426 290315000504 putative active site [active] 290315000505 heme pocket [chemical binding]; other site 290315000506 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290315000507 dimer interface [polypeptide binding]; other site 290315000508 phosphorylation site [posttranslational modification] 290315000509 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290315000510 ATP binding site [chemical binding]; other site 290315000511 Mg2+ binding site [ion binding]; other site 290315000512 G-X-G motif; other site 290315000513 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 290315000514 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290315000515 active site 290315000516 phosphorylation site [posttranslational modification] 290315000517 intermolecular recognition site; other site 290315000518 dimerization interface [polypeptide binding]; other site 290315000519 Rubredoxin [Energy production and conversion]; Region: COG1773 290315000520 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 290315000521 iron binding site [ion binding]; other site 290315000522 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 290315000523 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 290315000524 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 290315000525 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 290315000526 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 290315000527 NAD(P) binding site [chemical binding]; other site 290315000528 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 290315000529 putative ligand binding pocket/active site [active] 290315000530 putative metal binding site [ion binding]; other site 290315000531 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 290315000532 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 290315000533 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 290315000534 Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224 290315000535 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 290315000536 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 290315000537 Ligand binding site; other site 290315000538 Putative Catalytic site; other site 290315000539 DXD motif; other site 290315000540 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 290315000541 elongation factor G; Reviewed; Region: PRK12740 290315000542 G1 box; other site 290315000543 putative GEF interaction site [polypeptide binding]; other site 290315000544 GTP/Mg2+ binding site [chemical binding]; other site 290315000545 Switch I region; other site 290315000546 G2 box; other site 290315000547 G3 box; other site 290315000548 Switch II region; other site 290315000549 G4 box; other site 290315000550 G5 box; other site 290315000551 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 290315000552 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 290315000553 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 290315000554 enolase; Provisional; Region: eno; PRK00077 290315000555 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 290315000556 dimer interface [polypeptide binding]; other site 290315000557 metal binding site [ion binding]; metal-binding site 290315000558 substrate binding pocket [chemical binding]; other site 290315000559 Septum formation initiator; Region: DivIC; cl17659 290315000560 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional; Region: PRK02048 290315000561 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 290315000562 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 290315000563 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 290315000564 classical (c) SDRs; Region: SDR_c; cd05233 290315000565 NAD(P) binding site [chemical binding]; other site 290315000566 active site 290315000567 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 290315000568 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 290315000569 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 290315000570 putative homodimer interface [polypeptide binding]; other site 290315000571 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 290315000572 heterodimer interface [polypeptide binding]; other site 290315000573 homodimer interface [polypeptide binding]; other site 290315000574 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 290315000575 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 290315000576 23S rRNA interface [nucleotide binding]; other site 290315000577 L7/L12 interface [polypeptide binding]; other site 290315000578 putative thiostrepton binding site; other site 290315000579 L25 interface [polypeptide binding]; other site 290315000580 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 290315000581 mRNA/rRNA interface [nucleotide binding]; other site 290315000582 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 290315000583 23S rRNA interface [nucleotide binding]; other site 290315000584 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 290315000585 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 290315000586 core dimer interface [polypeptide binding]; other site 290315000587 peripheral dimer interface [polypeptide binding]; other site 290315000588 L10 interface [polypeptide binding]; other site 290315000589 L11 interface [polypeptide binding]; other site 290315000590 putative EF-Tu interaction site [polypeptide binding]; other site 290315000591 putative EF-G interaction site [polypeptide binding]; other site 290315000592 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 290315000593 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 290315000594 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 290315000595 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 290315000596 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 290315000597 RPB3 interaction site [polypeptide binding]; other site 290315000598 RPB1 interaction site [polypeptide binding]; other site 290315000599 RPB11 interaction site [polypeptide binding]; other site 290315000600 RPB10 interaction site [polypeptide binding]; other site 290315000601 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 290315000602 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 290315000603 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 290315000604 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 290315000605 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 290315000606 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 290315000607 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 290315000608 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 290315000609 DNA binding site [nucleotide binding] 290315000610 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 290315000611 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 290315000612 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290315000613 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 290315000614 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 290315000615 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 290315000616 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 290315000617 carboxyltransferase (CT) interaction site; other site 290315000618 biotinylation site [posttranslational modification]; other site 290315000619 elongation factor P; Validated; Region: PRK00529 290315000620 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 290315000621 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 290315000622 RNA binding site [nucleotide binding]; other site 290315000623 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 290315000624 RNA binding site [nucleotide binding]; other site 290315000625 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 290315000626 IHF - DNA interface [nucleotide binding]; other site 290315000627 IHF dimer interface [polypeptide binding]; other site 290315000628 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 290315000629 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 290315000630 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 290315000631 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 290315000632 TPP-binding site [chemical binding]; other site 290315000633 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 290315000634 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 290315000635 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 290315000636 PYR/PP interface [polypeptide binding]; other site 290315000637 TPP binding site [chemical binding]; other site 290315000638 dimer interface [polypeptide binding]; other site 290315000639 substrate binding site [chemical binding]; other site 290315000640 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 290315000641 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 290315000642 motif 1; other site 290315000643 active site 290315000644 motif 2; other site 290315000645 motif 3; other site 290315000646 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 290315000647 DHHA1 domain; Region: DHHA1; pfam02272 290315000648 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 290315000649 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290315000650 Ferredoxin [Energy production and conversion]; Region: COG1146 290315000651 Ferredoxin [Energy production and conversion]; Region: COG1146 290315000652 HipA-like N-terminal domain; Region: HipA_N; pfam07805 290315000653 HipA-like C-terminal domain; Region: HipA_C; pfam07804 290315000654 HipA N-terminal domain; Region: couple_hipA; TIGR03071 290315000655 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290315000656 non-specific DNA binding site [nucleotide binding]; other site 290315000657 salt bridge; other site 290315000658 sequence-specific DNA binding site [nucleotide binding]; other site 290315000659 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 290315000660 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 290315000661 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 290315000662 phosphoserine phosphatase SerB; Region: serB; TIGR00338 290315000663 Acid Phosphatase; Region: Acid_PPase; cl17256 290315000664 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290315000665 motif II; other site 290315000666 AAA domain; Region: AAA_14; pfam13173 290315000667 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 290315000668 AAA domain; Region: AAA_14; pfam13173 290315000669 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 290315000670 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290315000671 Transposase domain (DUF772); Region: DUF772; pfam05598 290315000672 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 290315000673 DDE superfamily endonuclease; Region: DDE_4; cl17710 290315000674 AAA ATPase domain; Region: AAA_16; pfam13191 290315000675 NACHT domain; Region: NACHT; pfam05729 290315000676 Transposase domain (DUF772); Region: DUF772; pfam05598 290315000677 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 290315000678 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 290315000679 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 290315000680 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290315000681 Walker A motif; other site 290315000682 ATP binding site [chemical binding]; other site 290315000683 Walker B motif; other site 290315000684 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 290315000685 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 290315000686 active site 290315000687 NTP binding site [chemical binding]; other site 290315000688 metal binding triad [ion binding]; metal-binding site 290315000689 antibiotic binding site [chemical binding]; other site 290315000690 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 290315000691 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 290315000692 non-specific DNA binding site [nucleotide binding]; other site 290315000693 salt bridge; other site 290315000694 sequence-specific DNA binding site [nucleotide binding]; other site 290315000695 HipA N-terminal domain; Region: Couple_hipA; cl11853 290315000696 HipA-like N-terminal domain; Region: HipA_N; pfam07805 290315000697 HipA-like C-terminal domain; Region: HipA_C; pfam07804 290315000698 AAA domain; Region: AAA_11; pfam13086 290315000699 Part of AAA domain; Region: AAA_19; pfam13245 290315000700 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 290315000701 AAA domain; Region: AAA_30; pfam13604 290315000702 AAA domain; Region: AAA_12; pfam13087 290315000703 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 290315000704 Transposase [DNA replication, recombination, and repair]; Region: COG5421 290315000705 GMP synthase; Reviewed; Region: guaA; PRK00074 290315000706 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 290315000707 AMP/PPi binding site [chemical binding]; other site 290315000708 candidate oxyanion hole; other site 290315000709 catalytic triad [active] 290315000710 potential glutamine specificity residues [chemical binding]; other site 290315000711 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 290315000712 ATP Binding subdomain [chemical binding]; other site 290315000713 Ligand Binding sites [chemical binding]; other site 290315000714 Dimerization subdomain; other site 290315000715 Transglycosylase; Region: Transgly; pfam00912 290315000716 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 290315000717 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 290315000718 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 290315000719 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 290315000720 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 290315000721 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 290315000722 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 290315000723 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 290315000724 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 290315000725 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290315000726 FeS/SAM binding site; other site 290315000727 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 290315000728 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 290315000729 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 290315000730 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 290315000731 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290315000732 putative NAD(P) binding site [chemical binding]; other site 290315000733 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 290315000734 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 290315000735 catalytic triad [active] 290315000736 Predicted ATPase [General function prediction only]; Region: COG3911 290315000737 AAA domain; Region: AAA_28; pfam13521 290315000738 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 290315000739 Clp amino terminal domain; Region: Clp_N; pfam02861 290315000740 Clp amino terminal domain; Region: Clp_N; pfam02861 290315000741 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290315000742 Walker A motif; other site 290315000743 ATP binding site [chemical binding]; other site 290315000744 Walker B motif; other site 290315000745 arginine finger; other site 290315000746 UvrB/uvrC motif; Region: UVR; pfam02151 290315000747 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290315000748 Walker A motif; other site 290315000749 ATP binding site [chemical binding]; other site 290315000750 Walker B motif; other site 290315000751 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 290315000752 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 290315000753 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 290315000754 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290315000755 catalytic residue [active] 290315000756 thiamine monophosphate kinase; Provisional; Region: PRK05731 290315000757 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 290315000758 ATP binding site [chemical binding]; other site 290315000759 dimerization interface [polypeptide binding]; other site 290315000760 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 290315000761 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 290315000762 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 290315000763 GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441 290315000764 GIY-YIG motif/motif A; other site 290315000765 putative active site [active] 290315000766 putative metal binding site [ion binding]; other site 290315000767 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 290315000768 Methyltransferase domain; Region: Methyltransf_18; pfam12847 290315000769 S-adenosylmethionine binding site [chemical binding]; other site 290315000770 SurA N-terminal domain; Region: SurA_N_3; cl07813 290315000771 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 290315000772 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 290315000773 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 290315000774 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 290315000775 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 290315000776 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 290315000777 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 290315000778 replicative DNA helicase; Region: DnaB; TIGR00665 290315000779 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 290315000780 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 290315000781 Walker A motif; other site 290315000782 ATP binding site [chemical binding]; other site 290315000783 Walker B motif; other site 290315000784 DNA binding loops [nucleotide binding] 290315000785 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 290315000786 Fe-S cluster binding site [ion binding]; other site 290315000787 active site 290315000788 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 290315000789 Flavoprotein; Region: Flavoprotein; pfam02441 290315000790 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 290315000791 Family of unknown function (DUF490); Region: DUF490; pfam04357 290315000792 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 290315000793 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 290315000794 active site 290315000795 HIGH motif; other site 290315000796 nucleotide binding site [chemical binding]; other site 290315000797 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 290315000798 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 290315000799 putative acyl-acceptor binding pocket; other site 290315000800 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290315000801 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290315000802 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 290315000803 Walker A/P-loop; other site 290315000804 ATP binding site [chemical binding]; other site 290315000805 Q-loop/lid; other site 290315000806 ABC transporter signature motif; other site 290315000807 Walker B; other site 290315000808 D-loop; other site 290315000809 H-loop/switch region; other site 290315000810 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 290315000811 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290315000812 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 290315000813 Protein of unknown function (DUF616); Region: DUF616; pfam04765 290315000814 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 290315000815 active site 290315000816 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 290315000817 putative ADP-binding pocket [chemical binding]; other site 290315000818 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 290315000819 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 290315000820 inhibitor-cofactor binding pocket; inhibition site 290315000821 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290315000822 catalytic residue [active] 290315000823 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 290315000824 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290315000825 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290315000826 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 290315000827 putative ADP-binding pocket [chemical binding]; other site 290315000828 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290315000829 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 290315000830 putative ADP-binding pocket [chemical binding]; other site 290315000831 hypothetical protein; Provisional; Region: PRK10345 290315000832 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290315000833 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 290315000834 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 290315000835 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290315000836 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290315000837 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 290315000838 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 290315000839 putative ADP-binding pocket [chemical binding]; other site 290315000840 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290315000841 CAAX protease self-immunity; Region: Abi; pfam02517 290315000842 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 290315000843 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 290315000844 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 290315000845 active site 290315000846 phosphorylation site [posttranslational modification] 290315000847 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 290315000848 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 290315000849 dimer interface [polypeptide binding]; other site 290315000850 motif 1; other site 290315000851 active site 290315000852 motif 2; other site 290315000853 motif 3; other site 290315000854 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 290315000855 anticodon binding site; other site 290315000856 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 290315000857 hypothetical protein; Provisional; Region: PRK14641 290315000858 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 290315000859 NusA N-terminal domain; Region: NusA_N; pfam08529 290315000860 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 290315000861 RNA binding site [nucleotide binding]; other site 290315000862 homodimer interface [polypeptide binding]; other site 290315000863 NusA-like KH domain; Region: KH_5; pfam13184 290315000864 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 290315000865 G-X-X-G motif; other site 290315000866 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 290315000867 translation initiation factor IF-2; Region: IF-2; TIGR00487 290315000868 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 290315000869 G1 box; other site 290315000870 putative GEF interaction site [polypeptide binding]; other site 290315000871 GTP/Mg2+ binding site [chemical binding]; other site 290315000872 Switch I region; other site 290315000873 G2 box; other site 290315000874 G3 box; other site 290315000875 Switch II region; other site 290315000876 G4 box; other site 290315000877 G5 box; other site 290315000878 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 290315000879 Translation-initiation factor 2; Region: IF-2; pfam11987 290315000880 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 290315000881 Ribosome-binding factor A; Region: RBFA; pfam02033 290315000882 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 290315000883 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 290315000884 RNA binding site [nucleotide binding]; other site 290315000885 active site 290315000886 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 290315000887 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 290315000888 active site 290315000889 Riboflavin kinase; Region: Flavokinase; pfam01687 290315000890 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 290315000891 16S/18S rRNA binding site [nucleotide binding]; other site 290315000892 S13e-L30e interaction site [polypeptide binding]; other site 290315000893 25S rRNA binding site [nucleotide binding]; other site 290315000894 hypothetical protein; Provisional; Region: PRK11820 290315000895 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 290315000896 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 290315000897 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 290315000898 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 290315000899 catalytic site [active] 290315000900 G-X2-G-X-G-K; other site 290315000901 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290315000902 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 290315000903 active site 290315000904 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 290315000905 Substrate binding site; other site 290315000906 Mg++ binding site; other site 290315000907 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 290315000908 tetramerization interface [polypeptide binding]; other site 290315000909 active site 290315000910 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 290315000911 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 290315000912 periplasmic chaperone; Provisional; Region: PRK10780 290315000913 DNA protecting protein DprA; Region: dprA; TIGR00732 290315000914 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 290315000915 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 290315000916 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 290315000917 substrate binding pocket [chemical binding]; other site 290315000918 chain length determination region; other site 290315000919 substrate-Mg2+ binding site; other site 290315000920 catalytic residues [active] 290315000921 aspartate-rich region 1; other site 290315000922 active site lid residues [active] 290315000923 aspartate-rich region 2; other site 290315000924 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 290315000925 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 290315000926 homotetramer interface [polypeptide binding]; other site 290315000927 FMN binding site [chemical binding]; other site 290315000928 homodimer contacts [polypeptide binding]; other site 290315000929 putative active site [active] 290315000930 putative substrate binding site [chemical binding]; other site 290315000931 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 290315000932 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290315000933 FtsX-like permease family; Region: FtsX; pfam02687 290315000934 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290315000935 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290315000936 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 290315000937 Walker A/P-loop; other site 290315000938 ATP binding site [chemical binding]; other site 290315000939 Q-loop/lid; other site 290315000940 ABC transporter signature motif; other site 290315000941 Walker B; other site 290315000942 D-loop; other site 290315000943 H-loop/switch region; other site 290315000944 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 290315000945 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 290315000946 active site 290315000947 substrate binding site [chemical binding]; other site 290315000948 metal binding site [ion binding]; metal-binding site 290315000949 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 290315000950 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 290315000951 RuvA N terminal domain; Region: RuvA_N; pfam01330 290315000952 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 290315000953 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 290315000954 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290315000955 transcription termination factor Rho; Provisional; Region: rho; PRK09376 290315000956 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 290315000957 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 290315000958 RNA binding site [nucleotide binding]; other site 290315000959 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 290315000960 multimer interface [polypeptide binding]; other site 290315000961 Walker A motif; other site 290315000962 ATP binding site [chemical binding]; other site 290315000963 Walker B motif; other site 290315000964 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290315000965 S-adenosylmethionine binding site [chemical binding]; other site 290315000966 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 290315000967 Ligand binding site [chemical binding]; other site 290315000968 Electron transfer flavoprotein domain; Region: ETF; pfam01012 290315000969 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 290315000970 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 290315000971 Ligand Binding Site [chemical binding]; other site 290315000972 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 290315000973 Bifunctional nuclease; Region: DNase-RNase; pfam02577 290315000974 UvrB/uvrC motif; Region: UVR; pfam02151 290315000975 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 290315000976 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 290315000977 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 290315000978 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 290315000979 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 290315000980 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 290315000981 Surface antigen; Region: Bac_surface_Ag; pfam01103 290315000982 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 290315000983 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 290315000984 catalytic residue [active] 290315000985 putative FPP diphosphate binding site; other site 290315000986 putative FPP binding hydrophobic cleft; other site 290315000987 dimer interface [polypeptide binding]; other site 290315000988 putative IPP diphosphate binding site; other site 290315000989 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 290315000990 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 290315000991 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 290315000992 CoA binding domain; Region: CoA_binding; smart00881 290315000993 CoA-ligase; Region: Ligase_CoA; pfam00549 290315000994 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 290315000995 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 290315000996 putative active site [active] 290315000997 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 290315000998 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 290315000999 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 290315001000 Heavy-metal resistance; Region: Metal_resist; pfam13801 290315001001 dimer interface [polypeptide binding]; other site 290315001002 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 290315001003 dimer interface [polypeptide binding]; other site 290315001004 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 290315001005 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290315001006 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290315001007 DNA binding residues [nucleotide binding] 290315001008 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 290315001009 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 290315001010 active site 290315001011 substrate binding site [chemical binding]; other site 290315001012 metal binding site [ion binding]; metal-binding site 290315001013 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 290315001014 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 290315001015 putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814 290315001016 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290315001017 catalytic loop [active] 290315001018 iron binding site [ion binding]; other site 290315001019 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290315001020 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290315001021 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 290315001022 LytB protein; Region: LYTB; cl00507 290315001023 glutamate racemase; Provisional; Region: PRK00865 290315001024 GTP-binding protein YchF; Reviewed; Region: PRK09601 290315001025 YchF GTPase; Region: YchF; cd01900 290315001026 G1 box; other site 290315001027 GTP/Mg2+ binding site [chemical binding]; other site 290315001028 Switch I region; other site 290315001029 G2 box; other site 290315001030 Switch II region; other site 290315001031 G3 box; other site 290315001032 G4 box; other site 290315001033 G5 box; other site 290315001034 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 290315001035 cytidylate kinase; Provisional; Region: cmk; PRK00023 290315001036 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 290315001037 CMP-binding site; other site 290315001038 The sites determining sugar specificity; other site 290315001039 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 290315001040 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 290315001041 RNA binding site [nucleotide binding]; other site 290315001042 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 290315001043 RNA binding site [nucleotide binding]; other site 290315001044 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 290315001045 RNA binding site [nucleotide binding]; other site 290315001046 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 290315001047 RNA binding site [nucleotide binding]; other site 290315001048 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 290315001049 RNA binding site [nucleotide binding]; other site 290315001050 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 290315001051 RNA binding site [nucleotide binding]; other site 290315001052 GTPase Era; Reviewed; Region: era; PRK00089 290315001053 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 290315001054 G1 box; other site 290315001055 GTP/Mg2+ binding site [chemical binding]; other site 290315001056 Switch I region; other site 290315001057 G2 box; other site 290315001058 Switch II region; other site 290315001059 G3 box; other site 290315001060 G4 box; other site 290315001061 G5 box; other site 290315001062 KH domain; Region: KH_2; pfam07650 290315001063 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 290315001064 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 290315001065 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 290315001066 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290315001067 FeS/SAM binding site; other site 290315001068 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290315001069 active site 290315001070 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 290315001071 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 290315001072 transmembrane helices; other site 290315001073 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 290315001074 IHF dimer interface [polypeptide binding]; other site 290315001075 IHF - DNA interface [nucleotide binding]; other site 290315001076 FtsH Extracellular; Region: FtsH_ext; pfam06480 290315001077 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 290315001078 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290315001079 Walker A motif; other site 290315001080 ATP binding site [chemical binding]; other site 290315001081 Walker B motif; other site 290315001082 arginine finger; other site 290315001083 Peptidase family M41; Region: Peptidase_M41; pfam01434 290315001084 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 290315001085 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 290315001086 HIGH motif; other site 290315001087 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 290315001088 active site 290315001089 KMSKS motif; other site 290315001090 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 290315001091 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 290315001092 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 290315001093 iron-sulfur cluster [ion binding]; other site 290315001094 [2Fe-2S] cluster binding site [ion binding]; other site 290315001095 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 290315001096 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 290315001097 intrachain domain interface; other site 290315001098 interchain domain interface [polypeptide binding]; other site 290315001099 heme bH binding site [chemical binding]; other site 290315001100 heme bL binding site [chemical binding]; other site 290315001101 Qo binding site; other site 290315001102 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 290315001103 interchain domain interface [polypeptide binding]; other site 290315001104 intrachain domain interface; other site 290315001105 Qi binding site; other site 290315001106 Qo binding site; other site 290315001107 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 290315001108 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 290315001109 active site 290315001110 catalytic site [active] 290315001111 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 290315001112 pteridine reductase; Provisional; Region: PRK09135 290315001113 classical (c) SDRs; Region: SDR_c; cd05233 290315001114 NAD(P) binding site [chemical binding]; other site 290315001115 active site 290315001116 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 290315001117 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 290315001118 Walker A/P-loop; other site 290315001119 ATP binding site [chemical binding]; other site 290315001120 Q-loop/lid; other site 290315001121 ABC transporter signature motif; other site 290315001122 Walker B; other site 290315001123 D-loop; other site 290315001124 H-loop/switch region; other site 290315001125 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 290315001126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290315001127 dimer interface [polypeptide binding]; other site 290315001128 conserved gate region; other site 290315001129 putative PBP binding loops; other site 290315001130 ABC-ATPase subunit interface; other site 290315001131 TOBE domain; Region: TOBE; cl01440 290315001132 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 290315001133 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 290315001134 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 290315001135 molybdenum transport protein ModD; Provisional; Region: PRK06096 290315001136 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 290315001137 dimerization interface [polypeptide binding]; other site 290315001138 active site 290315001139 PBP superfamily domain; Region: PBP_like_2; cl17296 290315001140 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 290315001141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290315001142 dimer interface [polypeptide binding]; other site 290315001143 conserved gate region; other site 290315001144 putative PBP binding loops; other site 290315001145 ABC-ATPase subunit interface; other site 290315001146 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 290315001147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290315001148 dimer interface [polypeptide binding]; other site 290315001149 conserved gate region; other site 290315001150 putative PBP binding loops; other site 290315001151 ABC-ATPase subunit interface; other site 290315001152 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 290315001153 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 290315001154 Walker A/P-loop; other site 290315001155 ATP binding site [chemical binding]; other site 290315001156 Q-loop/lid; other site 290315001157 ABC transporter signature motif; other site 290315001158 Walker B; other site 290315001159 D-loop; other site 290315001160 H-loop/switch region; other site 290315001161 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 290315001162 PhoU domain; Region: PhoU; pfam01895 290315001163 PhoU domain; Region: PhoU; pfam01895 290315001164 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 290315001165 Low molecular weight phosphatase family; Region: LMWPc; cd00115 290315001166 active site 290315001167 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 290315001168 arsenite oxidase, large subunit; Region: arsenite_ox_L; TIGR02693 290315001169 molybdopterin cofactor binding site; other site 290315001170 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 290315001171 molybdopterin cofactor binding site; other site 290315001172 Small subunit of Arsenite oxidase (ArOX) family, Rieske domain; ArOX is a molybdenum/iron protein involved in the detoxification of arsenic, oxidizing it to arsenate. It consists of two subunits, a large subunit similar to members of the DMSO reductase...; Region: Rieske_ArOX_small; cd03476 290315001173 [2Fe-2S] cluster binding site [ion binding]; other site 290315001174 subunit interaction site [polypeptide binding]; other site 290315001175 ribosome recycling factor; Reviewed; Region: frr; PRK00083 290315001176 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 290315001177 hinge region; other site 290315001178 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 290315001179 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 290315001180 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 290315001181 generic binding surface II; other site 290315001182 ssDNA binding site; other site 290315001183 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290315001184 ATP binding site [chemical binding]; other site 290315001185 putative Mg++ binding site [ion binding]; other site 290315001186 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290315001187 nucleotide binding region [chemical binding]; other site 290315001188 ATP-binding site [chemical binding]; other site 290315001189 GTPase RsgA; Reviewed; Region: PRK00098 290315001190 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 290315001191 RNA binding site [nucleotide binding]; other site 290315001192 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 290315001193 GTPase/Zn-binding domain interface [polypeptide binding]; other site 290315001194 GTP/Mg2+ binding site [chemical binding]; other site 290315001195 G4 box; other site 290315001196 G5 box; other site 290315001197 G1 box; other site 290315001198 Switch I region; other site 290315001199 G2 box; other site 290315001200 G3 box; other site 290315001201 Switch II region; other site 290315001202 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 290315001203 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 290315001204 NAD(P) binding site [chemical binding]; other site 290315001205 catalytic residues [active] 290315001206 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 290315001207 Low molecular weight phosphatase family; Region: LMWPc; cd00115 290315001208 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 290315001209 active site 290315001210 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 290315001211 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 290315001212 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 290315001213 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 290315001214 Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635 290315001215 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 290315001216 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 290315001217 glutamine binding [chemical binding]; other site 290315001218 catalytic triad [active] 290315001219 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 290315001220 Haem-binding domain; Region: Haem_bd; pfam14376 290315001221 Predicted transcriptional regulator [General function prediction only]; Region: COG2522 290315001222 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290315001223 sequence-specific DNA binding site [nucleotide binding]; other site 290315001224 salt bridge; other site 290315001225 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 290315001226 ResB-like family; Region: ResB; pfam05140 290315001227 Glycosyl hydrolase family 47; Region: Glyco_hydro_47; cl08327 290315001228 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 290315001229 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 290315001230 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 290315001231 stationary phase survival protein SurE; Provisional; Region: PRK13932 290315001232 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 290315001233 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 290315001234 active site 290315001235 nucleophile elbow; other site 290315001236 Surface antigen; Region: Bac_surface_Ag; pfam01103 290315001237 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 290315001238 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 290315001239 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 290315001240 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 290315001241 Clp protease; Region: CLP_protease; pfam00574 290315001242 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 290315001243 oligomer interface [polypeptide binding]; other site 290315001244 active site residues [active] 290315001245 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 290315001246 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290315001247 active site 290315001248 HIGH motif; other site 290315001249 nucleotide binding site [chemical binding]; other site 290315001250 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 290315001251 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 290315001252 active site 290315001253 KMSKS motif; other site 290315001254 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 290315001255 tRNA binding surface [nucleotide binding]; other site 290315001256 anticodon binding site; other site 290315001257 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 290315001258 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 290315001259 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 290315001260 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290315001261 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 290315001262 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290315001263 DNA binding residues [nucleotide binding] 290315001264 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 290315001265 Predicted permeases [General function prediction only]; Region: COG0795 290315001266 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 290315001267 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 290315001268 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 290315001269 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 290315001270 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 290315001271 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 290315001272 excinuclease ABC subunit B; Provisional; Region: PRK05298 290315001273 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290315001274 ATP binding site [chemical binding]; other site 290315001275 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290315001276 nucleotide binding region [chemical binding]; other site 290315001277 ATP-binding site [chemical binding]; other site 290315001278 Ultra-violet resistance protein B; Region: UvrB; pfam12344 290315001279 UvrB/uvrC motif; Region: UVR; pfam02151 290315001280 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 290315001281 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 290315001282 Zn2+ binding site [ion binding]; other site 290315001283 Mg2+ binding site [ion binding]; other site 290315001284 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 290315001285 synthetase active site [active] 290315001286 NTP binding site [chemical binding]; other site 290315001287 metal binding site [ion binding]; metal-binding site 290315001288 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 290315001289 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 290315001290 LemA family; Region: LemA; cl00742 290315001291 Repair protein; Region: Repair_PSII; pfam04536 290315001292 Repair protein; Region: Repair_PSII; cl01535 290315001293 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 290315001294 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 290315001295 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 290315001296 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 290315001297 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 290315001298 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 290315001299 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 290315001300 Domain of unknown function DUF59; Region: DUF59; pfam01883 290315001301 antiporter inner membrane protein; Provisional; Region: PRK11670 290315001302 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 290315001303 Walker A motif; other site 290315001304 GTP-binding protein Der; Reviewed; Region: PRK00093 290315001305 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 290315001306 G1 box; other site 290315001307 GTP/Mg2+ binding site [chemical binding]; other site 290315001308 Switch I region; other site 290315001309 G2 box; other site 290315001310 Switch II region; other site 290315001311 G3 box; other site 290315001312 G4 box; other site 290315001313 G5 box; other site 290315001314 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 290315001315 G1 box; other site 290315001316 GTP/Mg2+ binding site [chemical binding]; other site 290315001317 Switch I region; other site 290315001318 G2 box; other site 290315001319 G3 box; other site 290315001320 Switch II region; other site 290315001321 G4 box; other site 290315001322 G5 box; other site 290315001323 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 290315001324 23S rRNA interface [nucleotide binding]; other site 290315001325 L3 interface [polypeptide binding]; other site 290315001326 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 290315001327 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 290315001328 rRNA interaction site [nucleotide binding]; other site 290315001329 S8 interaction site; other site 290315001330 putative laminin-1 binding site; other site 290315001331 elongation factor Ts; Provisional; Region: tsf; PRK09377 290315001332 UBA/TS-N domain; Region: UBA; pfam00627 290315001333 Elongation factor TS; Region: EF_TS; pfam00889 290315001334 Elongation factor TS; Region: EF_TS; pfam00889 290315001335 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 290315001336 putative nucleotide binding site [chemical binding]; other site 290315001337 uridine monophosphate binding site [chemical binding]; other site 290315001338 homohexameric interface [polypeptide binding]; other site 290315001339 recombination regulator RecX; Reviewed; Region: recX; PRK00117 290315001340 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 290315001341 active site 290315001342 8-oxo-dGMP binding site [chemical binding]; other site 290315001343 nudix motif; other site 290315001344 metal binding site [ion binding]; metal-binding site 290315001345 metabolite-proton symporter; Region: 2A0106; TIGR00883 290315001346 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 290315001347 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 290315001348 active site 290315001349 metal binding site [ion binding]; metal-binding site 290315001350 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 290315001351 cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059 290315001352 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 290315001353 active site 290315001354 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 290315001355 Cadherin repeat-like domain; Region: CA_like; cl15786 290315001356 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 290315001357 Cadherin repeat-like domain; Region: CA_like; cl15786 290315001358 Ca2+ binding site [ion binding]; other site 290315001359 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 290315001360 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 290315001361 active site 290315001362 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 290315001363 Cadherin repeat-like domain; Region: CA_like; cl15786 290315001364 Cadherin repeat-like domain; Region: CA_like; cl15786 290315001365 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 290315001366 Ca2+ binding site [ion binding]; other site 290315001367 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 290315001368 Methyltransferase domain; Region: Methyltransf_18; pfam12847 290315001369 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 290315001370 Cation efflux family; Region: Cation_efflux; pfam01545 290315001371 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290315001372 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290315001373 NAD(P) binding site [chemical binding]; other site 290315001374 active site 290315001375 Cytochrome c; Region: Cytochrom_C; cl11414 290315001376 Cytochrome c; Region: Cytochrom_C; pfam00034 290315001377 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 290315001378 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 290315001379 Predicted transcriptional regulator [Transcription]; Region: COG2378 290315001380 WYL domain; Region: WYL; pfam13280 290315001381 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 290315001382 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 290315001383 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 290315001384 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 290315001385 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 290315001386 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 290315001387 CRISPR-associated protein Cas5, subtype I-B/TNEAP; Region: cas_Cas5t; TIGR01895 290315001388 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693 290315001389 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 290315001390 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 290315001391 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 290315001392 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 290315001393 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 290315001394 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 290315001395 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 290315001396 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 290315001397 active site 290315001398 catalytic site [active] 290315001399 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 290315001400 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 290315001401 Methyltransferase domain; Region: Methyltransf_23; pfam13489 290315001402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290315001403 S-adenosylmethionine binding site [chemical binding]; other site 290315001404 6-phosphofructokinase; Provisional; Region: PRK03202 290315001405 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 290315001406 active site 290315001407 ADP/pyrophosphate binding site [chemical binding]; other site 290315001408 dimerization interface [polypeptide binding]; other site 290315001409 allosteric effector site; other site 290315001410 fructose-1,6-bisphosphate binding site; other site 290315001411 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 290315001412 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 290315001413 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 290315001414 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 290315001415 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 290315001416 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 290315001417 pyruvate phosphate dikinase; Provisional; Region: PRK09279 290315001418 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 290315001419 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 290315001420 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 290315001421 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 290315001422 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 290315001423 TM-ABC transporter signature motif; other site 290315001424 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 290315001425 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 290315001426 conserved cys residue [active] 290315001427 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; pfam09603 290315001428 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 290315001429 Isochorismatase family; Region: Isochorismatase; pfam00857 290315001430 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 290315001431 catalytic triad [active] 290315001432 dimer interface [polypeptide binding]; other site 290315001433 conserved cis-peptide bond; other site 290315001434 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 290315001435 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 290315001436 putative acyl-acceptor binding pocket; other site 290315001437 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 290315001438 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 290315001439 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 290315001440 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 290315001441 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 290315001442 MPN+ (JAMM) motif; other site 290315001443 Zinc-binding site [ion binding]; other site 290315001444 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290315001445 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 290315001446 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 290315001447 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 290315001448 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 290315001449 active site 290315001450 ribulose/triose binding site [chemical binding]; other site 290315001451 phosphate binding site [ion binding]; other site 290315001452 substrate (anthranilate) binding pocket [chemical binding]; other site 290315001453 product (indole) binding pocket [chemical binding]; other site 290315001454 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 290315001455 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 290315001456 substrate binding site [chemical binding]; other site 290315001457 hexamer interface [polypeptide binding]; other site 290315001458 metal binding site [ion binding]; metal-binding site 290315001459 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 290315001460 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 290315001461 Surface antigen; Region: Bac_surface_Ag; pfam01103 290315001462 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 290315001463 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 290315001464 Peptidase family M23; Region: Peptidase_M23; pfam01551 290315001465 DNA polymerase I; Provisional; Region: PRK05755 290315001466 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 290315001467 active site 290315001468 metal binding site 1 [ion binding]; metal-binding site 290315001469 putative 5' ssDNA interaction site; other site 290315001470 metal binding site 3; metal-binding site 290315001471 metal binding site 2 [ion binding]; metal-binding site 290315001472 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 290315001473 putative DNA binding site [nucleotide binding]; other site 290315001474 putative metal binding site [ion binding]; other site 290315001475 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 290315001476 active site 290315001477 catalytic site [active] 290315001478 substrate binding site [chemical binding]; other site 290315001479 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 290315001480 active site 290315001481 DNA binding site [nucleotide binding] 290315001482 catalytic site [active] 290315001483 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 290315001484 Prephenate dehydratase; Region: PDT; pfam00800 290315001485 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 290315001486 putative L-Phe binding site [chemical binding]; other site 290315001487 hypothetical protein; Validated; Region: PRK00110 290315001488 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 290315001489 active site 290315001490 putative DNA-binding cleft [nucleotide binding]; other site 290315001491 dimer interface [polypeptide binding]; other site 290315001492 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 290315001493 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290315001494 binding surface 290315001495 TPR motif; other site 290315001496 TPR repeat; Region: TPR_11; pfam13414 290315001497 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290315001498 binding surface 290315001499 TPR motif; other site 290315001500 TPR repeat; Region: TPR_11; pfam13414 290315001501 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290315001502 binding surface 290315001503 TPR motif; other site 290315001504 TPR repeat; Region: TPR_11; pfam13414 290315001505 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290315001506 binding surface 290315001507 TPR motif; other site 290315001508 TPR repeat; Region: TPR_11; pfam13414 290315001509 peroxiredoxin; Provisional; Region: PRK13189 290315001510 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 290315001511 dimer interface [polypeptide binding]; other site 290315001512 decamer (pentamer of dimers) interface [polypeptide binding]; other site 290315001513 catalytic triad [active] 290315001514 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 290315001515 metal binding site 2 [ion binding]; metal-binding site 290315001516 putative DNA binding helix; other site 290315001517 metal binding site 1 [ion binding]; metal-binding site 290315001518 dimer interface [polypeptide binding]; other site 290315001519 structural Zn2+ binding site [ion binding]; other site 290315001520 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; pfam09603 290315001521 ribonuclease R; Region: RNase_R; TIGR02063 290315001522 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 290315001523 RNB domain; Region: RNB; pfam00773 290315001524 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 290315001525 RNA binding site [nucleotide binding]; other site 290315001526 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 290315001527 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 290315001528 catalytic triad [active] 290315001529 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 290315001530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290315001531 ATP binding site [chemical binding]; other site 290315001532 Mg2+ binding site [ion binding]; other site 290315001533 G-X-G motif; other site 290315001534 Response regulator receiver domain; Region: Response_reg; pfam00072 290315001535 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290315001536 active site 290315001537 phosphorylation site [posttranslational modification] 290315001538 intermolecular recognition site; other site 290315001539 dimerization interface [polypeptide binding]; other site 290315001540 Response regulator receiver domain; Region: Response_reg; pfam00072 290315001541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290315001542 active site 290315001543 phosphorylation site [posttranslational modification] 290315001544 intermolecular recognition site; other site 290315001545 dimerization interface [polypeptide binding]; other site 290315001546 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 290315001547 hypothetical protein; Provisional; Region: PRK07179 290315001548 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 290315001549 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290315001550 catalytic residue [active] 290315001551 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290315001552 active site residue [active] 290315001553 H-NS histone family; Region: Histone_HNS; pfam00816 290315001554 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 290315001555 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 290315001556 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 290315001557 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290315001558 catalytic residue [active] 290315001559 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 290315001560 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 290315001561 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 290315001562 catalytic site [active] 290315001563 Rrf2 family protein; Region: rrf2_super; TIGR00738 290315001564 Transcriptional regulator; Region: Rrf2; pfam02082 290315001565 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 290315001566 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 290315001567 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 290315001568 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 290315001569 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 290315001570 oligomerisation interface [polypeptide binding]; other site 290315001571 mobile loop; other site 290315001572 roof hairpin; other site 290315001573 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 290315001574 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 290315001575 ring oligomerisation interface [polypeptide binding]; other site 290315001576 ATP/Mg binding site [chemical binding]; other site 290315001577 stacking interactions; other site 290315001578 hinge regions; other site 290315001579 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 290315001580 Ligand Binding Site [chemical binding]; other site 290315001581 CAAX protease self-immunity; Region: Abi; pfam02517 290315001582 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 290315001583 substrate binding site [chemical binding]; other site 290315001584 active site 290315001585 catalytic residues [active] 290315001586 heterodimer interface [polypeptide binding]; other site 290315001587 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 290315001588 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 290315001589 Probable Catalytic site; other site 290315001590 metal-binding site 290315001591 cinnamyl-alcohol dehydrogenase family protein; Region: PLN02662 290315001592 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 290315001593 NADP binding site [chemical binding]; other site 290315001594 putative substrate binding site [chemical binding]; other site 290315001595 active site 290315001596 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866 290315001597 putative hydrophobic ligand binding site [chemical binding]; other site 290315001598 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 290315001599 active site 290315001600 META domain; Region: META; pfam03724 290315001601 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 290315001602 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 290315001603 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 290315001604 S-adenosylmethionine synthetase (AdoMet synthetase); Region: AdoMet_Synthase; pfam01941 290315001605 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 290315001606 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 290315001607 rod shape-determining protein MreB; Provisional; Region: PRK13930 290315001608 MreB and similar proteins; Region: MreB_like; cd10225 290315001609 nucleotide binding site [chemical binding]; other site 290315001610 Mg binding site [ion binding]; other site 290315001611 putative protofilament interaction site [polypeptide binding]; other site 290315001612 RodZ interaction site [polypeptide binding]; other site 290315001613 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 290315001614 histidinol dehydrogenase; Region: hisD; TIGR00069 290315001615 NAD binding site [chemical binding]; other site 290315001616 dimerization interface [polypeptide binding]; other site 290315001617 product binding site; other site 290315001618 substrate binding site [chemical binding]; other site 290315001619 zinc binding site [ion binding]; other site 290315001620 catalytic residues [active] 290315001621 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 290315001622 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 290315001623 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 290315001624 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 290315001625 substrate binding site [chemical binding]; other site 290315001626 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 290315001627 substrate binding site [chemical binding]; other site 290315001628 ligand binding site [chemical binding]; other site 290315001629 H-NS histone family; Region: Histone_HNS; pfam00816 290315001630 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 290315001631 Membrane transport protein; Region: Mem_trans; cl09117 290315001632 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 290315001633 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 290315001634 hinge; other site 290315001635 active site 290315001636 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 290315001637 Peptidase family M23; Region: Peptidase_M23; pfam01551 290315001638 NAD synthetase; Provisional; Region: PRK13980 290315001639 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 290315001640 homodimer interface [polypeptide binding]; other site 290315001641 NAD binding pocket [chemical binding]; other site 290315001642 ATP binding pocket [chemical binding]; other site 290315001643 Mg binding site [ion binding]; other site 290315001644 active-site loop [active] 290315001645 L-aspartate oxidase; Provisional; Region: PRK09077 290315001646 L-aspartate oxidase; Provisional; Region: PRK06175 290315001647 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 290315001648 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 290315001649 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 290315001650 pyruvoyl-dependent arginine decarboxylase; Reviewed; Region: PRK01285 290315001651 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 290315001652 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 290315001653 active site 290315001654 HIGH motif; other site 290315001655 dimer interface [polypeptide binding]; other site 290315001656 KMSKS motif; other site 290315001657 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290315001658 RNA binding surface [nucleotide binding]; other site 290315001659 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 290315001660 SmpB-tmRNA interface; other site 290315001661 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 290315001662 FAD binding domain; Region: FAD_binding_4; pfam01565 290315001663 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 290315001664 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 290315001665 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 290315001666 rod shape-determining protein MreC; Provisional; Region: PRK13922 290315001667 rod shape-determining protein MreC; Region: MreC; pfam04085 290315001668 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 290315001669 oligomerisation interface [polypeptide binding]; other site 290315001670 mobile loop; other site 290315001671 roof hairpin; other site 290315001672 Quinolinate synthetase A protein; Region: NadA; pfam02445 290315001673 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 290315001674 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 290315001675 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 290315001676 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 290315001677 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 290315001678 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 290315001679 active site 290315001680 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 290315001681 TSCPD domain; Region: TSCPD; pfam12637 290315001682 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 290315001683 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290315001684 Walker A/P-loop; other site 290315001685 ATP binding site [chemical binding]; other site 290315001686 Q-loop/lid; other site 290315001687 ABC transporter signature motif; other site 290315001688 Walker B; other site 290315001689 D-loop; other site 290315001690 H-loop/switch region; other site 290315001691 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 290315001692 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 290315001693 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 290315001694 TPR repeat; Region: TPR_11; pfam13414 290315001695 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290315001696 TPR motif; other site 290315001697 binding surface 290315001698 TPR repeat; Region: TPR_11; pfam13414 290315001699 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290315001700 binding surface 290315001701 TPR motif; other site 290315001702 TPR repeat; Region: TPR_11; pfam13414 290315001703 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 290315001704 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 290315001705 ATP binding site [chemical binding]; other site 290315001706 Mg++ binding site [ion binding]; other site 290315001707 motif III; other site 290315001708 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290315001709 nucleotide binding region [chemical binding]; other site 290315001710 ATP-binding site [chemical binding]; other site 290315001711 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 290315001712 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 290315001713 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 290315001714 Part of AAA domain; Region: AAA_19; pfam13245 290315001715 Family description; Region: UvrD_C_2; pfam13538 290315001716 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 290315001717 Flavoprotein; Region: Flavoprotein; cl08021 290315001718 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 290315001719 FMN binding site [chemical binding]; other site 290315001720 dimer interface [polypeptide binding]; other site 290315001721 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 290315001722 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 290315001723 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 290315001724 P loop; other site 290315001725 Nucleotide binding site [chemical binding]; other site 290315001726 DTAP/Switch II; other site 290315001727 Switch I; other site 290315001728 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 290315001729 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 290315001730 NAD binding site [chemical binding]; other site 290315001731 homotetramer interface [polypeptide binding]; other site 290315001732 homodimer interface [polypeptide binding]; other site 290315001733 substrate binding site [chemical binding]; other site 290315001734 active site 290315001735 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 290315001736 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 290315001737 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 290315001738 Pirin-related protein [General function prediction only]; Region: COG1741 290315001739 Pirin; Region: Pirin; pfam02678 290315001740 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 290315001741 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 290315001742 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 290315001743 putative active site [active] 290315001744 metal binding site [ion binding]; metal-binding site 290315001745 homodimer binding site [polypeptide binding]; other site 290315001746 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 290315001747 AMP binding site [chemical binding]; other site 290315001748 metal binding site [ion binding]; metal-binding site 290315001749 active site 290315001750 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 290315001751 DHH family; Region: DHH; pfam01368 290315001752 DHHA1 domain; Region: DHHA1; pfam02272 290315001753 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 290315001754 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 290315001755 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 290315001756 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 290315001757 TPR repeat; Region: TPR_11; pfam13414 290315001758 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 290315001759 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 290315001760 ligand binding site [chemical binding]; other site 290315001761 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 290315001762 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 290315001763 active site 290315001764 dimerization interface [polypeptide binding]; other site 290315001765 TspO/MBR family; Region: TspO_MBR; pfam03073 290315001766 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 290315001767 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 290315001768 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 290315001769 TIR domain; Region: TIR_2; pfam13676 290315001770 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 290315001771 Transposase domain (DUF772); Region: DUF772; pfam05598 290315001772 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 290315001773 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 290315001774 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 290315001775 active site 290315001776 nucleophile elbow; other site 290315001777 Part of AAA domain; Region: AAA_19; pfam13245 290315001778 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 290315001779 AAA domain; Region: AAA_12; pfam13087 290315001780 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 290315001781 putative active site [active] 290315001782 Protein of unknown function (DUF4019); Region: DUF4019; pfam13211 290315001783 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 290315001784 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 290315001785 TPR repeat; Region: TPR_11; pfam13414 290315001786 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290315001787 TPR motif; other site 290315001788 binding surface 290315001789 TPR repeat; Region: TPR_11; pfam13414 290315001790 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290315001791 binding surface 290315001792 TPR motif; other site 290315001793 TPR repeat; Region: TPR_11; pfam13414 290315001794 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290315001795 binding surface 290315001796 TPR motif; other site 290315001797 Tetratricopeptide repeat; Region: TPR_12; pfam13424 290315001798 TPR repeat; Region: TPR_11; pfam13414 290315001799 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 290315001800 active site 290315001801 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290315001802 non-specific DNA binding site [nucleotide binding]; other site 290315001803 salt bridge; other site 290315001804 sequence-specific DNA binding site [nucleotide binding]; other site 290315001805 Putative addiction module component; Region: Unstab_antitox; pfam09720 290315001806 AAA domain; Region: AAA_14; pfam13173 290315001807 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 290315001808 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 290315001809 dimer interface [polypeptide binding]; other site 290315001810 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 290315001811 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290315001812 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 290315001813 dimer interface [polypeptide binding]; other site 290315001814 [2Fe-2S] cluster binding site [ion binding]; other site 290315001815 acetyl-CoA synthetase; Provisional; Region: PRK00174 290315001816 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 290315001817 active site 290315001818 CoA binding site [chemical binding]; other site 290315001819 acyl-activating enzyme (AAE) consensus motif; other site 290315001820 AMP binding site [chemical binding]; other site 290315001821 acetate binding site [chemical binding]; other site 290315001822 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 290315001823 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 290315001824 HIGH motif; other site 290315001825 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 290315001826 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290315001827 active site 290315001828 KMSKS motif; other site 290315001829 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 290315001830 tRNA binding surface [nucleotide binding]; other site 290315001831 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 290315001832 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 290315001833 RNase E interface [polypeptide binding]; other site 290315001834 trimer interface [polypeptide binding]; other site 290315001835 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 290315001836 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 290315001837 RNase E interface [polypeptide binding]; other site 290315001838 trimer interface [polypeptide binding]; other site 290315001839 active site 290315001840 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 290315001841 putative nucleic acid binding region [nucleotide binding]; other site 290315001842 G-X-X-G motif; other site 290315001843 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 290315001844 RNA binding site [nucleotide binding]; other site 290315001845 domain interface; other site 290315001846 Pantoate-beta-alanine ligase; Region: PanC; cd00560 290315001847 pantoate--beta-alanine ligase; Region: panC; TIGR00018 290315001848 active site 290315001849 ATP-binding site [chemical binding]; other site 290315001850 pantoate-binding site; other site 290315001851 HXXH motif; other site 290315001852 Predicted methyltransferases [General function prediction only]; Region: COG0313 290315001853 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 290315001854 putative SAM binding site [chemical binding]; other site 290315001855 putative homodimer interface [polypeptide binding]; other site 290315001856 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 290315001857 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290315001858 Walker A/P-loop; other site 290315001859 ATP binding site [chemical binding]; other site 290315001860 Q-loop/lid; other site 290315001861 ABC transporter signature motif; other site 290315001862 Walker B; other site 290315001863 D-loop; other site 290315001864 H-loop/switch region; other site 290315001865 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 290315001866 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 290315001867 tandem repeat interface [polypeptide binding]; other site 290315001868 oligomer interface [polypeptide binding]; other site 290315001869 active site residues [active] 290315001870 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 290315001871 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 290315001872 tandem repeat interface [polypeptide binding]; other site 290315001873 oligomer interface [polypeptide binding]; other site 290315001874 active site residues [active] 290315001875 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 290315001876 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 290315001877 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290315001878 Walker A motif; other site 290315001879 ATP binding site [chemical binding]; other site 290315001880 Walker B motif; other site 290315001881 arginine finger; other site 290315001882 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 290315001883 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 290315001884 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 290315001885 Photosystem P840 reaction-centre cytochrome c-551; Region: Cytochrome-c551; pfam10643 290315001886 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 290315001887 Putative methyltransferase; Region: Methyltransf_16; pfam10294 290315001888 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 290315001889 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 290315001890 active site 290315001891 Int/Topo IB signature motif; other site 290315001892 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 290315001893 30S subunit binding site; other site 290315001894 HPr kinase/phosphorylase; Provisional; Region: PRK05428 290315001895 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 290315001896 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 290315001897 Hpr binding site; other site 290315001898 active site 290315001899 homohexamer subunit interaction site [polypeptide binding]; other site 290315001900 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 290315001901 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 290315001902 peptide binding site [polypeptide binding]; other site 290315001903 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 290315001904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290315001905 dimer interface [polypeptide binding]; other site 290315001906 conserved gate region; other site 290315001907 putative PBP binding loops; other site 290315001908 ABC-ATPase subunit interface; other site 290315001909 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 290315001910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290315001911 Walker A motif; other site 290315001912 ATP binding site [chemical binding]; other site 290315001913 Walker B motif; other site 290315001914 arginine finger; other site 290315001915 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 290315001916 TPR repeat; Region: TPR_11; pfam13414 290315001917 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290315001918 binding surface 290315001919 TPR motif; other site 290315001920 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290315001921 TPR motif; other site 290315001922 binding surface 290315001923 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290315001924 TPR motif; other site 290315001925 binding surface 290315001926 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 290315001927 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 290315001928 dimer interface [polypeptide binding]; other site 290315001929 PYR/PP interface [polypeptide binding]; other site 290315001930 TPP binding site [chemical binding]; other site 290315001931 substrate binding site [chemical binding]; other site 290315001932 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 290315001933 Domain of unknown function; Region: EKR; pfam10371 290315001934 4Fe-4S binding domain; Region: Fer4_6; pfam12837 290315001935 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 290315001936 TPP-binding site [chemical binding]; other site 290315001937 dimer interface [polypeptide binding]; other site 290315001938 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 290315001939 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 290315001940 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 290315001941 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 290315001942 lipoyl attachment site [posttranslational modification]; other site 290315001943 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 290315001944 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 290315001945 tetramer interface [polypeptide binding]; other site 290315001946 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290315001947 catalytic residue [active] 290315001948 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 290315001949 dihydrodipicolinate synthase; Region: dapA; TIGR00674 290315001950 dimer interface [polypeptide binding]; other site 290315001951 active site 290315001952 catalytic residue [active] 290315001953 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 290315001954 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 290315001955 Walker A/P-loop; other site 290315001956 ATP binding site [chemical binding]; other site 290315001957 Q-loop/lid; other site 290315001958 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 290315001959 ABC transporter signature motif; other site 290315001960 Walker B; other site 290315001961 D-loop; other site 290315001962 H-loop/switch region; other site 290315001963 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 290315001964 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 290315001965 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 290315001966 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 290315001967 Ligand Binding Site [chemical binding]; other site 290315001968 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 290315001969 RNA/DNA hybrid binding site [nucleotide binding]; other site 290315001970 active site 290315001971 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 290315001972 bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566 290315001973 UbiA prenyltransferase family; Region: UbiA; pfam01040 290315001974 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 290315001975 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 290315001976 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 290315001977 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 290315001978 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 290315001979 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 290315001980 active site 290315001981 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 290315001982 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 290315001983 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 290315001984 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 290315001985 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 290315001986 Ligand binding site; other site 290315001987 Putative Catalytic site; other site 290315001988 DXD motif; other site 290315001989 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 290315001990 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 290315001991 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 290315001992 active site 290315001993 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 290315001994 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 290315001995 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 290315001996 putative active site [active] 290315001997 putative substrate binding site [chemical binding]; other site 290315001998 putative cosubstrate binding site; other site 290315001999 catalytic site [active] 290315002000 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 290315002001 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 290315002002 Tetratricopeptide repeat; Region: TPR_12; pfam13424 290315002003 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290315002004 binding surface 290315002005 Tetratricopeptide repeat; Region: TPR_16; pfam13432 290315002006 TPR motif; other site 290315002007 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 290315002008 Helix-turn-helix domain; Region: HTH_17; pfam12728 290315002009 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 290315002010 DNA methylase; Region: N6_N4_Mtase; pfam01555 290315002011 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 290315002012 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 290315002013 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 290315002014 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 290315002015 putative active site [active] 290315002016 Protein of unknown function, DUF486; Region: DUF486; cl01236 290315002017 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 290315002018 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290315002019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290315002020 Walker A/P-loop; other site 290315002021 ATP binding site [chemical binding]; other site 290315002022 Q-loop/lid; other site 290315002023 ABC transporter signature motif; other site 290315002024 Walker B; other site 290315002025 D-loop; other site 290315002026 H-loop/switch region; other site 290315002027 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 290315002028 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 290315002029 ATP binding site [chemical binding]; other site 290315002030 substrate interface [chemical binding]; other site 290315002031 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 290315002032 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290315002033 FeS/SAM binding site; other site 290315002034 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 290315002035 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 290315002036 ThiS interaction site; other site 290315002037 putative active site [active] 290315002038 tetramer interface [polypeptide binding]; other site 290315002039 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 290315002040 thiS-thiF/thiG interaction site; other site 290315002041 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 290315002042 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 290315002043 homodimer interface [polypeptide binding]; other site 290315002044 substrate-cofactor binding pocket; other site 290315002045 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290315002046 catalytic residue [active] 290315002047 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 290315002048 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 290315002049 homodimer interface [polypeptide binding]; other site 290315002050 substrate-cofactor binding pocket; other site 290315002051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290315002052 catalytic residue [active] 290315002053 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 290315002054 MOSC domain; Region: MOSC; pfam03473 290315002055 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 290315002056 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290315002057 FeS/SAM binding site; other site 290315002058 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 290315002059 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 290315002060 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 290315002061 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 290315002062 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 290315002063 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 290315002064 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290315002065 dimer interface [polypeptide binding]; other site 290315002066 conserved gate region; other site 290315002067 putative PBP binding loops; other site 290315002068 ABC-ATPase subunit interface; other site 290315002069 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 290315002070 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 290315002071 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 290315002072 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 290315002073 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 290315002074 dimer interface [polypeptide binding]; other site 290315002075 [2Fe-2S] cluster binding site [ion binding]; other site 290315002076 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 290315002077 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290315002078 FeS/SAM binding site; other site 290315002079 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 290315002080 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 290315002081 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 290315002082 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 290315002083 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 290315002084 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 290315002085 MoFe protein beta/alpha subunit interactions; other site 290315002086 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 290315002087 Beta subunit P cluster binding residues; other site 290315002088 MoFe protein beta subunit/Fe protein contacts; other site 290315002089 MoFe protein dimer/ dimer interactions; other site 290315002090 nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284 290315002091 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 290315002092 MoFe protein alpha/beta subunit interactions; other site 290315002093 Alpha subunit P cluster binding residues; other site 290315002094 FeMoco binding residues [chemical binding]; other site 290315002095 MoFe protein alpha subunit/Fe protein contacts; other site 290315002096 MoFe protein dimer/ dimer interactions; other site 290315002097 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 290315002098 Nitrogen regulatory protein P-II; Region: P-II; smart00938 290315002099 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 290315002100 Nitrogen regulatory protein P-II; Region: P-II; smart00938 290315002101 nitrogenase reductase; Reviewed; Region: nifH; PRK13235 290315002102 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 290315002103 Nucleotide-binding sites [chemical binding]; other site 290315002104 Walker A motif; other site 290315002105 Switch I region of nucleotide binding site; other site 290315002106 Fe4S4 binding sites [ion binding]; other site 290315002107 Switch II region of nucleotide binding site; other site 290315002108 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 290315002109 active site 290315002110 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 290315002111 catalytic tetrad [active] 290315002112 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290315002113 dimer interface [polypeptide binding]; other site 290315002114 phosphorylation site [posttranslational modification] 290315002115 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290315002116 ATP binding site [chemical binding]; other site 290315002117 Mg2+ binding site [ion binding]; other site 290315002118 G-X-G motif; other site 290315002119 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 290315002120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290315002121 active site 290315002122 phosphorylation site [posttranslational modification] 290315002123 intermolecular recognition site; other site 290315002124 dimerization interface [polypeptide binding]; other site 290315002125 Nif-specific regulatory protein; Region: nifA; TIGR01817 290315002126 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 290315002127 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290315002128 Walker A motif; other site 290315002129 ATP binding site [chemical binding]; other site 290315002130 Walker B motif; other site 290315002131 arginine finger; other site 290315002132 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 290315002133 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 290315002134 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 290315002135 active site 290315002136 catalytic residues [active] 290315002137 metal binding site [ion binding]; metal-binding site 290315002138 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290315002139 active site residue [active] 290315002140 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 290315002141 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 290315002142 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 290315002143 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 290315002144 catalytic triad [active] 290315002145 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 290315002146 DsrC like protein; Region: DsrC; pfam04358 290315002147 sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064 290315002148 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 290315002149 sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066 290315002150 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 290315002151 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 290315002152 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 290315002153 sulfur relay protein TusD/DsrE; Region: sulf_tusD_dsrE; TIGR03012 290315002154 sulfur relay protein TusC/DsrF; Region: sulf_tusC_dsrF; TIGR03010 290315002155 DsrH like protein; Region: DsrH; pfam04077 290315002156 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 290315002157 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 290315002158 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 290315002159 Cysteine-rich domain; Region: CCG; pfam02754 290315002160 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 290315002161 4Fe-4S binding domain; Region: Fer4; cl02805 290315002162 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 290315002163 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 290315002164 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 290315002165 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 290315002166 active site 290315002167 SAM binding site [chemical binding]; other site 290315002168 homodimer interface [polypeptide binding]; other site 290315002169 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 290315002170 active site 290315002171 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290315002172 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 290315002173 Walker A motif; other site 290315002174 ATP binding site [chemical binding]; other site 290315002175 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290315002176 putative DNA binding site [nucleotide binding]; other site 290315002177 putative Zn2+ binding site [ion binding]; other site 290315002178 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 290315002179 binding surface 290315002180 TPR motif; other site 290315002181 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290315002182 binding surface 290315002183 TPR motif; other site 290315002184 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 290315002185 AAA ATPase domain; Region: AAA_16; pfam13191 290315002186 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 290315002187 conserved FAD binding motif [chemical binding]; other site 290315002188 hypothetical protein; Provisional; Region: PRK07079 290315002189 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 290315002190 Integrase core domain; Region: rve; pfam00665 290315002191 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 290315002192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290315002193 Walker A motif; other site 290315002194 ATP binding site [chemical binding]; other site 290315002195 Walker B motif; other site 290315002196 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 290315002197 Transposase IS200 like; Region: Y1_Tnp; cl00848 290315002198 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 290315002199 Methyltransferase domain; Region: Methyltransf_31; pfam13847 290315002200 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290315002201 S-adenosylmethionine binding site [chemical binding]; other site 290315002202 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 290315002203 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 290315002204 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 290315002205 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 290315002206 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 290315002207 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 290315002208 Uncharacterized conserved protein [Function unknown]; Region: COG2308 290315002209 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 290315002210 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290315002211 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 290315002212 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 290315002213 active site 290315002214 catalytic residues [active] 290315002215 metal binding site [ion binding]; metal-binding site 290315002216 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 290315002217 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 290315002218 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 290315002219 substrate binding site [chemical binding]; other site 290315002220 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 290315002221 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 290315002222 substrate binding site [chemical binding]; other site 290315002223 ligand binding site [chemical binding]; other site 290315002224 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 290315002225 tartrate dehydrogenase; Region: TTC; TIGR02089 290315002226 ketol-acid reductoisomerase; Provisional; Region: PRK05479 290315002227 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 290315002228 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 290315002229 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 290315002230 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 290315002231 putative valine binding site [chemical binding]; other site 290315002232 dimer interface [polypeptide binding]; other site 290315002233 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 290315002234 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 290315002235 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 290315002236 PYR/PP interface [polypeptide binding]; other site 290315002237 dimer interface [polypeptide binding]; other site 290315002238 TPP binding site [chemical binding]; other site 290315002239 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 290315002240 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 290315002241 TPP-binding site [chemical binding]; other site 290315002242 dimer interface [polypeptide binding]; other site 290315002243 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 290315002244 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 290315002245 Integral membrane protein DUF92; Region: DUF92; pfam01940 290315002246 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 290315002247 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 290315002248 TolR protein; Region: tolR; TIGR02801 290315002249 TonB C terminal; Region: TonB_2; pfam13103 290315002250 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 290315002251 TolB amino-terminal domain; Region: TolB_N; pfam04052 290315002252 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 290315002253 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 290315002254 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 290315002255 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 290315002256 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 290315002257 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 290315002258 ligand binding site [chemical binding]; other site 290315002259 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 290315002260 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 290315002261 ligand binding site [chemical binding]; other site 290315002262 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 290315002263 Tetratricopeptide repeat; Region: TPR_6; pfam13174 290315002264 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 290315002265 FeoA domain; Region: FeoA; pfam04023 290315002266 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 290315002267 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 290315002268 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 290315002269 G1 box; other site 290315002270 GTP/Mg2+ binding site [chemical binding]; other site 290315002271 Switch I region; other site 290315002272 G2 box; other site 290315002273 G3 box; other site 290315002274 Switch II region; other site 290315002275 G4 box; other site 290315002276 G5 box; other site 290315002277 Nucleoside recognition; Region: Gate; pfam07670 290315002278 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 290315002279 Nucleoside recognition; Region: Gate; pfam07670 290315002280 FeoC like transcriptional regulator; Region: FeoC; pfam09012 290315002281 flavodoxin FldA; Validated; Region: PRK09267 290315002282 Photosystem P840 reaction centre protein PscD; Region: RC-P840_PscD; pfam10657 290315002283 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 290315002284 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 290315002285 active site 290315002286 DNA binding site [nucleotide binding] 290315002287 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 290315002288 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 290315002289 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 290315002290 nucleotide binding site [chemical binding]; other site 290315002291 NEF interaction site [polypeptide binding]; other site 290315002292 SBD interface [polypeptide binding]; other site 290315002293 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 290315002294 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 290315002295 putative dimer interface [polypeptide binding]; other site 290315002296 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290315002297 dimerization interface [polypeptide binding]; other site 290315002298 putative DNA binding site [nucleotide binding]; other site 290315002299 putative Zn2+ binding site [ion binding]; other site 290315002300 Putative zinc-finger; Region: zf-HC2; pfam13490 290315002301 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 290315002302 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 290315002303 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290315002304 DNA binding residues [nucleotide binding] 290315002305 carotene isomerase; Region: carot_isom; TIGR02730 290315002306 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 290315002307 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 290315002308 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 290315002309 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 290315002310 hexamer interface [polypeptide binding]; other site 290315002311 ligand binding site [chemical binding]; other site 290315002312 putative active site [active] 290315002313 NAD(P) binding site [chemical binding]; other site 290315002314 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 290315002315 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 290315002316 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290315002317 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 290315002318 catalytic loop [active] 290315002319 iron binding site [ion binding]; other site 290315002320 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 290315002321 DEAD-like helicases superfamily; Region: DEXDc; smart00487 290315002322 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290315002323 ATP binding site [chemical binding]; other site 290315002324 putative Mg++ binding site [ion binding]; other site 290315002325 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290315002326 nucleotide binding region [chemical binding]; other site 290315002327 ATP-binding site [chemical binding]; other site 290315002328 TRCF domain; Region: TRCF; pfam03461 290315002329 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 290315002330 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 290315002331 Walker A/P-loop; other site 290315002332 ATP binding site [chemical binding]; other site 290315002333 Q-loop/lid; other site 290315002334 ABC transporter signature motif; other site 290315002335 Walker B; other site 290315002336 D-loop; other site 290315002337 H-loop/switch region; other site 290315002338 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 290315002339 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290315002340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290315002341 active site 290315002342 phosphorylation site [posttranslational modification] 290315002343 intermolecular recognition site; other site 290315002344 dimerization interface [polypeptide binding]; other site 290315002345 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290315002346 DNA binding site [nucleotide binding] 290315002347 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290315002348 dimerization interface [polypeptide binding]; other site 290315002349 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 290315002350 PAS domain; Region: PAS; smart00091 290315002351 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290315002352 dimer interface [polypeptide binding]; other site 290315002353 phosphorylation site [posttranslational modification] 290315002354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290315002355 ATP binding site [chemical binding]; other site 290315002356 Mg2+ binding site [ion binding]; other site 290315002357 G-X-G motif; other site 290315002358 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 290315002359 Mechanosensitive ion channel; Region: MS_channel; pfam00924 290315002360 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 290315002361 nudix motif; other site 290315002362 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 290315002363 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 290315002364 catalytic triad [active] 290315002365 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 290315002366 Transposase IS200 like; Region: Y1_Tnp; cl00848 290315002367 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 290315002368 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 290315002369 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 290315002370 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 290315002371 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 290315002372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 290315002373 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 290315002374 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 290315002375 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 290315002376 Divergent AAA domain; Region: AAA_4; pfam04326 290315002377 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 290315002378 Transposase domain (DUF772); Region: DUF772; pfam05598 290315002379 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 290315002380 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 290315002381 Fic family protein [Function unknown]; Region: COG3177 290315002382 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 290315002383 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 290315002384 DNA methylase; Region: N6_N4_Mtase; pfam01555 290315002385 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 290315002386 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 290315002387 G1 box; other site 290315002388 putative GEF interaction site [polypeptide binding]; other site 290315002389 GTP/Mg2+ binding site [chemical binding]; other site 290315002390 Switch I region; other site 290315002391 G2 box; other site 290315002392 G3 box; other site 290315002393 Switch II region; other site 290315002394 G4 box; other site 290315002395 G5 box; other site 290315002396 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 290315002397 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 290315002398 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 290315002399 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 290315002400 dimer interface [polypeptide binding]; other site 290315002401 substrate binding site [chemical binding]; other site 290315002402 metal binding sites [ion binding]; metal-binding site 290315002403 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 290315002404 fumarate hydratase; Reviewed; Region: fumC; PRK00485 290315002405 Class II fumarases; Region: Fumarase_classII; cd01362 290315002406 active site 290315002407 tetramer interface [polypeptide binding]; other site 290315002408 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 290315002409 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 290315002410 NeuB family; Region: NeuB; pfam03102 290315002411 heat shock protein 90; Provisional; Region: PRK05218 290315002412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290315002413 ATP binding site [chemical binding]; other site 290315002414 Mg2+ binding site [ion binding]; other site 290315002415 G-X-G motif; other site 290315002416 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 290315002417 diiron binding motif [ion binding]; other site 290315002418 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 290315002419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 290315002420 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 290315002421 AAA domain; Region: AAA_33; pfam13671 290315002422 ATP-binding site [chemical binding]; other site 290315002423 Gluconate-6-phosphate binding site [chemical binding]; other site 290315002424 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290315002425 Ligand Binding Site [chemical binding]; other site 290315002426 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 290315002427 Fumarase C-terminus; Region: Fumerase_C; pfam05683 290315002428 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; cl01458 290315002429 Winged helix-turn helix; Region: HTH_29; pfam13551 290315002430 Helix-turn-helix domain; Region: HTH_28; pfam13518 290315002431 Winged helix-turn helix; Region: HTH_33; pfam13592 290315002432 DDE superfamily endonuclease; Region: DDE_3; pfam13358 290315002433 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 290315002434 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 290315002435 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 290315002436 active site 290315002437 catalytic residues [active] 290315002438 metal binding site [ion binding]; metal-binding site 290315002439 homodimer binding site [polypeptide binding]; other site 290315002440 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 290315002441 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 290315002442 carboxyltransferase (CT) interaction site; other site 290315002443 biotinylation site [posttranslational modification]; other site 290315002444 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 290315002445 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 290315002446 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 290315002447 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 290315002448 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 290315002449 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 290315002450 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 290315002451 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 290315002452 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 290315002453 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 290315002454 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 290315002455 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 290315002456 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 290315002457 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 290315002458 active site 290315002459 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 290315002460 generic binding surface II; other site 290315002461 generic binding surface I; other site 290315002462 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 290315002463 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 290315002464 catalytic residues [active] 290315002465 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 290315002466 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290315002467 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290315002468 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 290315002469 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 290315002470 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 290315002471 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 290315002472 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 290315002473 putative active site [active] 290315002474 putative metal binding site [ion binding]; other site 290315002475 SdiA-regulated; Region: SdiA-regulated; pfam06977 290315002476 SdiA-regulated; Region: SdiA-regulated; cd09971 290315002477 putative active site [active] 290315002478 Surface antigen; Region: Bac_surface_Ag; pfam01103 290315002479 cyclase homology domain; Region: CHD; cd07302 290315002480 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 290315002481 nucleotidyl binding site; other site 290315002482 metal binding site [ion binding]; metal-binding site 290315002483 dimer interface [polypeptide binding]; other site 290315002484 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 290315002485 Zn2+ binding site [ion binding]; other site 290315002486 Mg2+ binding site [ion binding]; other site 290315002487 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 290315002488 active site 290315002489 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 290315002490 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290315002491 motif II; other site 290315002492 Methyltransferase domain; Region: Methyltransf_31; pfam13847 290315002493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290315002494 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 290315002495 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 290315002496 Domain of unknown function (DUF814); Region: DUF814; pfam05670 290315002497 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 290315002498 catalytic motif [active] 290315002499 Zn binding site [ion binding]; other site 290315002500 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 290315002501 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 290315002502 catalytic motif [active] 290315002503 Zn binding site [ion binding]; other site 290315002504 RibD C-terminal domain; Region: RibD_C; cl17279 290315002505 Predicted membrane protein [Function unknown]; Region: COG2259 290315002506 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 290315002507 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 290315002508 dimer interface [polypeptide binding]; other site 290315002509 catalytic triad [active] 290315002510 peroxidatic and resolving cysteines [active] 290315002511 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_5; cd11352 290315002512 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 290315002513 active site 290315002514 catalytic site [active] 290315002515 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 290315002516 Lumazine binding domain; Region: Lum_binding; pfam00677 290315002517 Lumazine binding domain; Region: Lum_binding; pfam00677 290315002518 recombination factor protein RarA; Reviewed; Region: PRK13342 290315002519 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290315002520 Walker A motif; other site 290315002521 ATP binding site [chemical binding]; other site 290315002522 Walker B motif; other site 290315002523 arginine finger; other site 290315002524 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 290315002525 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 290315002526 Methyltransferase domain; Region: Methyltransf_23; pfam13489 290315002527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290315002528 S-adenosylmethionine binding site [chemical binding]; other site 290315002529 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 290315002530 nucleotide binding site/active site [active] 290315002531 HIT family signature motif; other site 290315002532 catalytic residue [active] 290315002533 Ferrochelatase; Region: Ferrochelatase; pfam00762 290315002534 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 290315002535 C-terminal domain interface [polypeptide binding]; other site 290315002536 active site 290315002537 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 290315002538 active site 290315002539 N-terminal domain interface [polypeptide binding]; other site 290315002540 TPR repeat; Region: TPR_11; pfam13414 290315002541 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290315002542 binding surface 290315002543 TPR motif; other site 290315002544 TPR repeat; Region: TPR_11; pfam13414 290315002545 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290315002546 binding surface 290315002547 TPR repeat; Region: TPR_11; pfam13414 290315002548 TPR motif; other site 290315002549 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 290315002550 NADH dehydrogenase subunit B; Provisional; Region: PRK14813 290315002551 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 290315002552 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 290315002553 NADH dehydrogenase subunit D; Validated; Region: PRK06075 290315002554 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 290315002555 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 290315002556 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 290315002557 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 290315002558 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 290315002559 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 290315002560 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 290315002561 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 290315002562 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 290315002563 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 290315002564 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 290315002565 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 290315002566 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 290315002567 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 290315002568 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 290315002569 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 290315002570 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 290315002571 Ni/Fe-hydrogenase, b-type cytochrome subunit; Region: CytB-hydogenase; TIGR02125 290315002572 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 290315002573 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 290315002574 putative substrate-binding site; other site 290315002575 nickel binding site [ion binding]; other site 290315002576 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 290315002577 homodecamer interface [polypeptide binding]; other site 290315002578 GTP cyclohydrolase I; Provisional; Region: PLN03044 290315002579 active site 290315002580 putative catalytic site residues [active] 290315002581 zinc binding site [ion binding]; other site 290315002582 GTP-CH-I/GFRP interaction surface; other site 290315002583 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 290315002584 active site 290315002585 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 290315002586 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 290315002587 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 290315002588 catalytic residues [active] 290315002589 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 290315002590 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 290315002591 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 290315002592 active site residues [active] 290315002593 dimer interface [polypeptide binding]; other site 290315002594 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 290315002595 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 290315002596 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 290315002597 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290315002598 Ligand Binding Site [chemical binding]; other site 290315002599 membrane ATPase/protein kinase; Provisional; Region: PRK09435 290315002600 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 290315002601 Walker A; other site 290315002602 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 290315002603 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 290315002604 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 290315002605 active site 290315002606 substrate binding site [chemical binding]; other site 290315002607 coenzyme B12 binding site [chemical binding]; other site 290315002608 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 290315002609 B12 binding site [chemical binding]; other site 290315002610 cobalt ligand [ion binding]; other site 290315002611 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 290315002612 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 290315002613 heterodimer interface [polypeptide binding]; other site 290315002614 substrate interaction site [chemical binding]; other site 290315002615 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 290315002616 acetyl-coenzyme A carboxylase carboxyl transferase; Provisional; Region: PLN03230 290315002617 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290315002618 substrate binding site [chemical binding]; other site 290315002619 oxyanion hole (OAH) forming residues; other site 290315002620 trimer interface [polypeptide binding]; other site 290315002621 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 290315002622 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 290315002623 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 290315002624 dimer interface [polypeptide binding]; other site 290315002625 substrate binding site [chemical binding]; other site 290315002626 metal binding site [ion binding]; metal-binding site 290315002627 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 290315002628 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 290315002629 acyl-activating enzyme (AAE) consensus motif; other site 290315002630 putative AMP binding site [chemical binding]; other site 290315002631 putative active site [active] 290315002632 putative CoA binding site [chemical binding]; other site 290315002633 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 290315002634 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 290315002635 S-adenosylmethionine binding site [chemical binding]; other site 290315002636 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 290315002637 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 290315002638 PYR/PP interface [polypeptide binding]; other site 290315002639 dimer interface [polypeptide binding]; other site 290315002640 TPP binding site [chemical binding]; other site 290315002641 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290315002642 hypothetical protein; Provisional; Region: PRK14621 290315002643 recombination protein RecR; Reviewed; Region: recR; PRK00076 290315002644 RecR protein; Region: RecR; pfam02132 290315002645 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 290315002646 putative active site [active] 290315002647 putative metal-binding site [ion binding]; other site 290315002648 tetramer interface [polypeptide binding]; other site 290315002649 phytoene desaturase; Region: phytoene_desat; TIGR02731 290315002650 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 290315002651 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 290315002652 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 290315002653 metal-binding site [ion binding] 290315002654 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290315002655 Soluble P-type ATPase [General function prediction only]; Region: COG4087 290315002656 serine acetyltransferase; Provisional; Region: cysE; PRK11132 290315002657 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 290315002658 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 290315002659 trimer interface [polypeptide binding]; other site 290315002660 active site 290315002661 substrate binding site [chemical binding]; other site 290315002662 CoA binding site [chemical binding]; other site 290315002663 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 290315002664 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 290315002665 Tetramer interface [polypeptide binding]; other site 290315002666 active site 290315002667 FMN-binding site [chemical binding]; other site 290315002668 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 290315002669 dimer interface [polypeptide binding]; other site 290315002670 allosteric magnesium binding site [ion binding]; other site 290315002671 active site 290315002672 aspartate-rich active site metal binding site; other site 290315002673 Schiff base residues; other site 290315002674 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 290315002675 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 290315002676 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 290315002677 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 290315002678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290315002679 ATP binding site [chemical binding]; other site 290315002680 Mg2+ binding site [ion binding]; other site 290315002681 G-X-G motif; other site 290315002682 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 290315002683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290315002684 active site 290315002685 phosphorylation site [posttranslational modification] 290315002686 intermolecular recognition site; other site 290315002687 dimerization interface [polypeptide binding]; other site 290315002688 Response regulator receiver domain; Region: Response_reg; pfam00072 290315002689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290315002690 active site 290315002691 phosphorylation site [posttranslational modification] 290315002692 intermolecular recognition site; other site 290315002693 dimerization interface [polypeptide binding]; other site 290315002694 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 290315002695 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 290315002696 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 290315002697 carboxyltransferase (CT) interaction site; other site 290315002698 biotinylation site [posttranslational modification]; other site 290315002699 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 290315002700 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 290315002701 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 290315002702 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 290315002703 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 290315002704 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 290315002705 active site 290315002706 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 290315002707 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 290315002708 active site 290315002709 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 290315002710 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 290315002711 domain interfaces; other site 290315002712 active site 290315002713 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 290315002714 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 290315002715 tRNA; other site 290315002716 putative tRNA binding site [nucleotide binding]; other site 290315002717 putative NADP binding site [chemical binding]; other site 290315002718 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 290315002719 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 290315002720 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 290315002721 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 290315002722 G1 box; other site 290315002723 putative GEF interaction site [polypeptide binding]; other site 290315002724 GTP/Mg2+ binding site [chemical binding]; other site 290315002725 Switch I region; other site 290315002726 G2 box; other site 290315002727 G3 box; other site 290315002728 Switch II region; other site 290315002729 G4 box; other site 290315002730 G5 box; other site 290315002731 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 290315002732 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 290315002733 chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016 290315002734 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 290315002735 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 290315002736 DNA binding residues [nucleotide binding] 290315002737 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202 290315002738 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 290315002739 putative NAD(P) binding site [chemical binding]; other site 290315002740 2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284 290315002741 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 290315002742 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 290315002743 peptide binding site [polypeptide binding]; other site 290315002744 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 290315002745 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 290315002746 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 290315002747 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 290315002748 trimer interface [polypeptide binding]; other site 290315002749 active site 290315002750 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 290315002751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290315002752 active site 290315002753 phosphorylation site [posttranslational modification] 290315002754 intermolecular recognition site; other site 290315002755 dimerization interface [polypeptide binding]; other site 290315002756 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290315002757 Walker A motif; other site 290315002758 ATP binding site [chemical binding]; other site 290315002759 Walker B motif; other site 290315002760 arginine finger; other site 290315002761 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 290315002762 chlorosome envelope protein H repeat; Region: rpt_csmH; TIGR03058 290315002763 chlorosome envelope protein H repeat; Region: rpt_csmH; TIGR03058 290315002764 YXWGXW repeat (2 copies); Region: YXWGXW; pfam12779 290315002765 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 290315002766 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 290315002767 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 290315002768 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290315002769 putative ADP-binding pocket [chemical binding]; other site 290315002770 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 290315002771 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 290315002772 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 290315002773 Probable Catalytic site; other site 290315002774 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 290315002775 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290315002776 FeS/SAM binding site; other site 290315002777 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 290315002778 phytoene desaturase; Region: phytoene_desat; TIGR02731 290315002779 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 290315002780 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 290315002781 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290315002782 dimerization interface [polypeptide binding]; other site 290315002783 putative DNA binding site [nucleotide binding]; other site 290315002784 putative Zn2+ binding site [ion binding]; other site 290315002785 AsnC family; Region: AsnC_trans_reg; pfam01037 290315002786 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 290315002787 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 290315002788 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 290315002789 Uncharacterized conserved protein [Function unknown]; Region: COG0432 290315002790 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 290315002791 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 290315002792 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 290315002793 Transposase IS200 like; Region: Y1_Tnp; cl00848 290315002794 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 290315002795 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 290315002796 AAA domain; Region: AAA_14; pfam13173 290315002797 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 290315002798 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 290315002799 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 290315002800 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 290315002801 putative active site [active] 290315002802 putative NTP binding site [chemical binding]; other site 290315002803 putative nucleic acid binding site [nucleotide binding]; other site 290315002804 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 290315002805 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 290315002806 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 290315002807 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09701 290315002808 CRISPR-associated protein, Csx11 family; Region: cas_csx11; TIGR02682 290315002809 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 290315002810 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 290315002811 Helix-turn-helix domain; Region: HTH_28; pfam13518 290315002812 putative transposase OrfB; Reviewed; Region: PHA02517 290315002813 HTH-like domain; Region: HTH_21; pfam13276 290315002814 Integrase core domain; Region: rve; pfam00665 290315002815 Integrase core domain; Region: rve_3; pfam13683 290315002816 pantothenate kinase; Reviewed; Region: PRK13320 290315002817 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 290315002818 active site 290315002819 dimer interface [polypeptide binding]; other site 290315002820 metal binding site [ion binding]; metal-binding site 290315002821 shikimate kinase; Reviewed; Region: aroK; PRK00131 290315002822 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 290315002823 ADP binding site [chemical binding]; other site 290315002824 magnesium binding site [ion binding]; other site 290315002825 putative shikimate binding site; other site 290315002826 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 290315002827 AAA domain; Region: AAA_30; pfam13604 290315002828 Family description; Region: UvrD_C_2; pfam13538 290315002829 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 290315002830 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 290315002831 catalytic triad [active] 290315002832 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 290315002833 classical (c) SDRs; Region: SDR_c; cd05233 290315002834 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 290315002835 NAD(P) binding site [chemical binding]; other site 290315002836 active site 290315002837 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 290315002838 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 290315002839 Uncharacterized conserved protein [Function unknown]; Region: COG1434 290315002840 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 290315002841 putative active site [active] 290315002842 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 290315002843 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 290315002844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290315002845 S-adenosylmethionine binding site [chemical binding]; other site 290315002846 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 290315002847 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290315002848 S-adenosylmethionine binding site [chemical binding]; other site 290315002849 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 290315002850 anti sigma factor interaction site; other site 290315002851 regulatory phosphorylation site [posttranslational modification]; other site 290315002852 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 290315002853 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 290315002854 Maf-like protein; Region: Maf; pfam02545 290315002855 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 290315002856 active site 290315002857 dimer interface [polypeptide binding]; other site 290315002858 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 290315002859 Na binding site [ion binding]; other site 290315002860 Ribokinase-like subgroup C. Found only in bacteria, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_C; cd01946 290315002861 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290315002862 substrate binding site [chemical binding]; other site 290315002863 ATP binding site [chemical binding]; other site 290315002864 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 290315002865 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 290315002866 active site 290315002867 catalytic site [active] 290315002868 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 290315002869 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 290315002870 dimerization interface 3.5A [polypeptide binding]; other site 290315002871 active site 290315002872 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 290315002873 N-acetyl-D-glucosamine binding site [chemical binding]; other site 290315002874 catalytic residue [active] 290315002875 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 290315002876 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 290315002877 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 290315002878 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 290315002879 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 290315002880 P loop; other site 290315002881 Nucleotide binding site [chemical binding]; other site 290315002882 DTAP/Switch II; other site 290315002883 Switch I; other site 290315002884 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 290315002885 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 290315002886 ligand binding site [chemical binding]; other site 290315002887 NAD binding site [chemical binding]; other site 290315002888 dimerization interface [polypeptide binding]; other site 290315002889 catalytic site [active] 290315002890 ACT_3PGDH-like CD includes the C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-like; cd04879 290315002891 L-serine binding site [chemical binding]; other site 290315002892 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 290315002893 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 290315002894 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 290315002895 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 290315002896 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 290315002897 Nitrogen regulatory protein P-II; Region: P-II; smart00938 290315002898 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 290315002899 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 290315002900 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290315002901 ATP binding site [chemical binding]; other site 290315002902 Mg2+ binding site [ion binding]; other site 290315002903 G-X-G motif; other site 290315002904 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 290315002905 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 290315002906 active site 290315002907 dimer interface [polypeptide binding]; other site 290315002908 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 290315002909 dimer interface [polypeptide binding]; other site 290315002910 active site 290315002911 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 290315002912 ApbE family; Region: ApbE; pfam02424 290315002913 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 290315002914 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 290315002915 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 290315002916 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 290315002917 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12509 290315002918 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12659 290315002919 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 290315002920 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 290315002921 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 290315002922 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 290315002923 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 290315002924 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 290315002925 electron transport complex RsxE subunit; Provisional; Region: PRK12405 290315002926 FMN-binding domain; Region: FMN_bind; cl01081 290315002927 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 290315002928 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 290315002929 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 290315002930 SLBB domain; Region: SLBB; pfam10531 290315002931 ferredoxin; Validated; Region: PRK07118 290315002932 Putative Fe-S cluster; Region: FeS; cl17515 290315002933 4Fe-4S binding domain; Region: Fer4; pfam00037 290315002934 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 290315002935 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 290315002936 adenylosuccinate lyase; Provisional; Region: PRK07492 290315002937 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 290315002938 tetramer interface [polypeptide binding]; other site 290315002939 active site 290315002940 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 290315002941 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 290315002942 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 290315002943 active site 290315002944 NTP binding site [chemical binding]; other site 290315002945 metal binding triad [ion binding]; metal-binding site 290315002946 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 290315002947 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 290315002948 Zn2+ binding site [ion binding]; other site 290315002949 Mg2+ binding site [ion binding]; other site 290315002950 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 290315002951 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290315002952 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290315002953 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290315002954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290315002955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290315002956 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 290315002957 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 290315002958 cobalamin binding residues [chemical binding]; other site 290315002959 putative BtuC binding residues; other site 290315002960 dimer interface [polypeptide binding]; other site 290315002961 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 290315002962 nudix motif; other site 290315002963 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 290315002964 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290315002965 non-specific DNA binding site [nucleotide binding]; other site 290315002966 salt bridge; other site 290315002967 sequence-specific DNA binding site [nucleotide binding]; other site 290315002968 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 290315002969 putative hydrophobic ligand binding site [chemical binding]; other site 290315002970 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 290315002971 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 290315002972 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 290315002973 PhoU domain; Region: PhoU; pfam01895 290315002974 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 290315002975 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290315002976 N-terminal plug; other site 290315002977 ligand-binding site [chemical binding]; other site 290315002978 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 290315002979 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 290315002980 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 290315002981 putative ligand binding site [chemical binding]; other site 290315002982 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 290315002983 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290315002984 ABC-ATPase subunit interface; other site 290315002985 dimer interface [polypeptide binding]; other site 290315002986 putative PBP binding regions; other site 290315002987 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 290315002988 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 290315002989 Walker A/P-loop; other site 290315002990 ATP binding site [chemical binding]; other site 290315002991 Q-loop/lid; other site 290315002992 ABC transporter signature motif; other site 290315002993 Walker B; other site 290315002994 D-loop; other site 290315002995 H-loop/switch region; other site 290315002996 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 290315002997 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 290315002998 intersubunit interface [polypeptide binding]; other site 290315002999 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 290315003000 Predicted amidohydrolase [General function prediction only]; Region: COG0388 290315003001 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 290315003002 active site 290315003003 catalytic triad [active] 290315003004 dimer interface [polypeptide binding]; other site 290315003005 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 290315003006 active site 290315003007 catalytic triad [active] 290315003008 dimer interface [polypeptide binding]; other site 290315003009 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 290315003010 active site 290315003011 SAM binding site [chemical binding]; other site 290315003012 homodimer interface [polypeptide binding]; other site 290315003013 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 290315003014 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 290315003015 active site 290315003016 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 290315003017 active site 290315003018 N-terminal domain interface [polypeptide binding]; other site 290315003019 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 290315003020 active site 290315003021 SAM binding site [chemical binding]; other site 290315003022 homodimer interface [polypeptide binding]; other site 290315003023 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 290315003024 active site 290315003025 SAM binding site [chemical binding]; other site 290315003026 homodimer interface [polypeptide binding]; other site 290315003027 Precorrin-8X methylmutase; Region: CbiC; pfam02570 290315003028 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 290315003029 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 290315003030 active site 290315003031 putative homodimer interface [polypeptide binding]; other site 290315003032 SAM binding site [chemical binding]; other site 290315003033 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 290315003034 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290315003035 S-adenosylmethionine binding site [chemical binding]; other site 290315003036 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 290315003037 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 290315003038 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 290315003039 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 290315003040 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 290315003041 active site 290315003042 SAM binding site [chemical binding]; other site 290315003043 homodimer interface [polypeptide binding]; other site 290315003044 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 290315003045 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 290315003046 Metal-binding active site; metal-binding site 290315003047 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290315003048 GeoRSP system radical SAM/SPASM protein; Region: GeoRSP_rSAM; TIGR04303 290315003049 FeS/SAM binding site; other site 290315003050 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 290315003051 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 290315003052 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 290315003053 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 290315003054 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 290315003055 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 290315003056 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 290315003057 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290315003058 Walker A motif; other site 290315003059 ATP binding site [chemical binding]; other site 290315003060 Walker B motif; other site 290315003061 arginine finger; other site 290315003062 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 290315003063 metal ion-dependent adhesion site (MIDAS); other site 290315003064 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 290315003065 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 290315003066 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 290315003067 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 290315003068 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 290315003069 Cna protein B-type domain; Region: Cna_B_2; pfam13715 290315003070 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 290315003071 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290315003072 N-terminal plug; other site 290315003073 ligand-binding site [chemical binding]; other site 290315003074 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 290315003075 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 290315003076 intersubunit interface [polypeptide binding]; other site 290315003077 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 290315003078 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 290315003079 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 290315003080 Protein of unknown function, DUF399; Region: DUF399; pfam04187 290315003081 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 290315003082 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 290315003083 nucleotide binding site [chemical binding]; other site 290315003084 putative NEF/HSP70 interaction site [polypeptide binding]; other site 290315003085 SBD interface [polypeptide binding]; other site 290315003086 Ycf46; Provisional; Region: ycf46; CHL00195 290315003087 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290315003088 Walker A motif; other site 290315003089 ATP binding site [chemical binding]; other site 290315003090 Walker B motif; other site 290315003091 arginine finger; other site 290315003092 Uncharacterized conserved protein [Function unknown]; Region: COG1262 290315003093 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 290315003094 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 290315003095 DNA binding site [nucleotide binding] 290315003096 active site 290315003097 Int/Topo IB signature motif; other site 290315003098 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 290315003099 active site 290315003100 NTP binding site [chemical binding]; other site 290315003101 metal binding triad [ion binding]; metal-binding site 290315003102 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 290315003103 active site 290315003104 nucleophile elbow; other site 290315003105 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 290315003106 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 290315003107 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 290315003108 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 290315003109 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 290315003110 Transposase [DNA replication, recombination, and repair]; Region: COG5421 290315003111 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 290315003112 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 290315003113 ATP cone domain; Region: ATP-cone; pfam03477 290315003114 Class III ribonucleotide reductase; Region: RNR_III; cd01675 290315003115 effector binding site; other site 290315003116 active site 290315003117 Zn binding site [ion binding]; other site 290315003118 glycine loop; other site 290315003119 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 290315003120 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290315003121 FeS/SAM binding site; other site 290315003122 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 290315003123 cobalt transport protein CbiM; Validated; Region: PRK08319 290315003124 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 290315003125 cobalt transport protein CbiN; Provisional; Region: PRK02898 290315003126 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 290315003127 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13636 290315003128 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 290315003129 Walker A/P-loop; other site 290315003130 ATP binding site [chemical binding]; other site 290315003131 Q-loop/lid; other site 290315003132 ABC transporter signature motif; other site 290315003133 Walker B; other site 290315003134 D-loop; other site 290315003135 H-loop/switch region; other site 290315003136 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 290315003137 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290315003138 N-terminal plug; other site 290315003139 ligand-binding site [chemical binding]; other site 290315003140 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 290315003141 putative FMN binding site [chemical binding]; other site 290315003142 cobyric acid synthase; Provisional; Region: PRK00784 290315003143 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 290315003144 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 290315003145 catalytic triad [active] 290315003146 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 290315003147 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290315003148 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290315003149 homodimer interface [polypeptide binding]; other site 290315003150 catalytic residue [active] 290315003151 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 290315003152 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 290315003153 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 290315003154 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290315003155 ABC-ATPase subunit interface; other site 290315003156 dimer interface [polypeptide binding]; other site 290315003157 putative PBP binding regions; other site 290315003158 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 290315003159 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 290315003160 Walker A/P-loop; other site 290315003161 ATP binding site [chemical binding]; other site 290315003162 Q-loop/lid; other site 290315003163 ABC transporter signature motif; other site 290315003164 Walker B; other site 290315003165 D-loop; other site 290315003166 H-loop/switch region; other site 290315003167 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 290315003168 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 290315003169 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 290315003170 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 290315003171 homotrimer interface [polypeptide binding]; other site 290315003172 Walker A motif; other site 290315003173 GTP binding site [chemical binding]; other site 290315003174 Walker B motif; other site 290315003175 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 290315003176 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 290315003177 putative dimer interface [polypeptide binding]; other site 290315003178 active site pocket [active] 290315003179 putative cataytic base [active] 290315003180 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 290315003181 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 290315003182 catalytic site [active] 290315003183 cobalamin synthase; Reviewed; Region: cobS; PRK00235 290315003184 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 290315003185 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290315003186 putative active site [active] 290315003187 heme pocket [chemical binding]; other site 290315003188 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290315003189 dimer interface [polypeptide binding]; other site 290315003190 phosphorylation site [posttranslational modification] 290315003191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290315003192 ATP binding site [chemical binding]; other site 290315003193 Mg2+ binding site [ion binding]; other site 290315003194 G-X-G motif; other site 290315003195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290315003196 Response regulator receiver domain; Region: Response_reg; pfam00072 290315003197 active site 290315003198 phosphorylation site [posttranslational modification] 290315003199 intermolecular recognition site; other site 290315003200 dimerization interface [polypeptide binding]; other site 290315003201 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 290315003202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290315003203 active site 290315003204 phosphorylation site [posttranslational modification] 290315003205 intermolecular recognition site; other site 290315003206 dimerization interface [polypeptide binding]; other site 290315003207 Dicarboxylate transport; Region: DctA-YdbH; cl14674 290315003208 Dicarboxylate transport; Region: DctA-YdbH; cl14674 290315003209 Dicarboxylate transport; Region: DctA-YdbH; cl14674 290315003210 Dicarboxylate transport; Region: DctA-YdbH; pfam11739 290315003211 Protein of unknown function (DUF1318); Region: DUF1318; pfam07027 290315003212 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 290315003213 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 290315003214 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 290315003215 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 290315003216 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 290315003217 catalytic residues [active] 290315003218 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; pfam06941 290315003219 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 290315003220 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 290315003221 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 290315003222 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 290315003223 putative RNA binding site [nucleotide binding]; other site 290315003224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290315003225 S-adenosylmethionine binding site [chemical binding]; other site 290315003226 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 290315003227 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 290315003228 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 290315003229 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 290315003230 dephospho-CoA kinase; Provisional; Region: coaE; PRK14731 290315003231 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 290315003232 CoA-binding site [chemical binding]; other site 290315003233 ATP-binding [chemical binding]; other site 290315003234 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 290315003235 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 290315003236 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 290315003237 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 290315003238 substrate binding pocket [chemical binding]; other site 290315003239 chain length determination region; other site 290315003240 substrate-Mg2+ binding site; other site 290315003241 catalytic residues [active] 290315003242 aspartate-rich region 1; other site 290315003243 active site lid residues [active] 290315003244 aspartate-rich region 2; other site 290315003245 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290315003246 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290315003247 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 290315003248 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 290315003249 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 290315003250 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 290315003251 Cl- selectivity filter; other site 290315003252 Cl- binding residues [ion binding]; other site 290315003253 pore gating glutamate residue; other site 290315003254 dimer interface [polypeptide binding]; other site 290315003255 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 290315003256 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 290315003257 Walker A/P-loop; other site 290315003258 ATP binding site [chemical binding]; other site 290315003259 Q-loop/lid; other site 290315003260 ABC transporter signature motif; other site 290315003261 Walker B; other site 290315003262 D-loop; other site 290315003263 H-loop/switch region; other site 290315003264 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290315003265 Walker A/P-loop; other site 290315003266 ATP binding site [chemical binding]; other site 290315003267 Q-loop/lid; other site 290315003268 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202 290315003269 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 290315003270 putative NAD(P) binding site [chemical binding]; other site 290315003271 Membrane protein of unknown function; Region: DUF360; pfam04020 290315003272 DNA repair protein RadA; Provisional; Region: PRK11823 290315003273 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 290315003274 Walker A motif/ATP binding site; other site 290315003275 ATP binding site [chemical binding]; other site 290315003276 Walker B motif; other site 290315003277 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 290315003278 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14174 290315003279 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 290315003280 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 290315003281 homodimer interface [polypeptide binding]; other site 290315003282 NADP binding site [chemical binding]; other site 290315003283 substrate binding site [chemical binding]; other site 290315003284 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 290315003285 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 290315003286 NAD(P) binding site [chemical binding]; other site 290315003287 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 290315003288 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 290315003289 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 290315003290 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307 290315003291 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 290315003292 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 290315003293 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 290315003294 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 290315003295 active site 290315003296 HslU subunit interaction site [polypeptide binding]; other site 290315003297 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 290315003298 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 290315003299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290315003300 Walker A motif; other site 290315003301 ATP binding site [chemical binding]; other site 290315003302 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 290315003303 Walker B motif; other site 290315003304 arginine finger; other site 290315003305 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 290315003306 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 290315003307 Dehydroquinase class II; Region: DHquinase_II; pfam01220 290315003308 trimer interface [polypeptide binding]; other site 290315003309 active site 290315003310 dimer interface [polypeptide binding]; other site 290315003311 Cna protein B-type domain; Region: Cna_B_2; pfam13715 290315003312 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 290315003313 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 290315003314 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290315003315 Phytase; Region: Phytase; cl17685 290315003316 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 290315003317 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 290315003318 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 290315003319 dimer interface [polypeptide binding]; other site 290315003320 PYR/PP interface [polypeptide binding]; other site 290315003321 TPP binding site [chemical binding]; other site 290315003322 substrate binding site [chemical binding]; other site 290315003323 2-oxoacid ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11869 290315003324 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 290315003325 TPP-binding site [chemical binding]; other site 290315003326 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 290315003327 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 290315003328 aromatic arch; other site 290315003329 DCoH dimer interaction site [polypeptide binding]; other site 290315003330 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 290315003331 DCoH tetramer interaction site [polypeptide binding]; other site 290315003332 substrate binding site [chemical binding]; other site 290315003333 2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284 290315003334 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 290315003335 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 290315003336 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 290315003337 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 290315003338 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 290315003339 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 290315003340 putative FMN binding site [chemical binding]; other site 290315003341 NADPH bind site [chemical binding]; other site 290315003342 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 290315003343 nudix motif; other site 290315003344 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 290315003345 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 290315003346 metal binding site [ion binding]; metal-binding site 290315003347 dimer interface [polypeptide binding]; other site 290315003348 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 290315003349 active site 290315003350 dimer interfaces [polypeptide binding]; other site 290315003351 catalytic residues [active] 290315003352 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 290315003353 putative metal binding site [ion binding]; other site 290315003354 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 290315003355 putative catalytic site [active] 290315003356 putative phosphate binding site [ion binding]; other site 290315003357 putative metal binding site [ion binding]; other site 290315003358 Predicted DNA-binding proteins [General function prediction only]; Region: COG1342 290315003359 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 290315003360 DNA binding residues [nucleotide binding] 290315003361 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 290315003362 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 290315003363 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 290315003364 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 290315003365 Rhodanese Homology Domain; Region: RHOD; smart00450 290315003366 active site residue [active] 290315003367 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 290315003368 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 290315003369 active site residue [active] 290315003370 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 290315003371 active site residue [active] 290315003372 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 290315003373 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 290315003374 active site 290315003375 FMN binding site [chemical binding]; other site 290315003376 substrate binding site [chemical binding]; other site 290315003377 putative catalytic residue [active] 290315003378 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 290315003379 amphipathic channel; other site 290315003380 Asn-Pro-Ala signature motifs; other site 290315003381 zinc transporter ZupT; Provisional; Region: PRK04201 290315003382 ZIP Zinc transporter; Region: Zip; pfam02535 290315003383 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 290315003384 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 290315003385 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 290315003386 active site 290315003387 bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566 290315003388 UbiA prenyltransferase family; Region: UbiA; pfam01040 290315003389 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 290315003390 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290315003391 Coenzyme A binding pocket [chemical binding]; other site 290315003392 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 290315003393 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 290315003394 iron-sulfur cluster [ion binding]; other site 290315003395 [2Fe-2S] cluster binding site [ion binding]; other site 290315003396 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 290315003397 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 290315003398 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 290315003399 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 290315003400 B12 binding site [chemical binding]; other site 290315003401 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 290315003402 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290315003403 FeS/SAM binding site; other site 290315003404 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 290315003405 PhoH-like protein; Region: PhoH; pfam02562 290315003406 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 290315003407 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 290315003408 NADP binding site [chemical binding]; other site 290315003409 homopentamer interface [polypeptide binding]; other site 290315003410 substrate binding site [chemical binding]; other site 290315003411 active site 290315003412 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 290315003413 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 290315003414 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290315003415 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290315003416 homodimer interface [polypeptide binding]; other site 290315003417 catalytic residue [active] 290315003418 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 290315003419 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 290315003420 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290315003421 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 290315003422 putative active site [active] 290315003423 catalytic residue [active] 290315003424 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 290315003425 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 290315003426 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 290315003427 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 290315003428 Pathogenicity locus; Region: Cdd1; pfam11731 290315003429 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 290315003430 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 290315003431 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 290315003432 putative homodimer interface [polypeptide binding]; other site 290315003433 putative homotetramer interface [polypeptide binding]; other site 290315003434 putative metal binding site [ion binding]; other site 290315003435 putative homodimer-homodimer interface [polypeptide binding]; other site 290315003436 putative allosteric switch controlling residues; other site 290315003437 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 290315003438 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 290315003439 putative catalytic site [active] 290315003440 putative metal binding site [ion binding]; other site 290315003441 putative phosphate binding site [ion binding]; other site 290315003442 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 290315003443 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 290315003444 ATP binding site [chemical binding]; other site 290315003445 active site 290315003446 substrate binding site [chemical binding]; other site 290315003447 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 290315003448 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 290315003449 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 290315003450 TPP-binding site [chemical binding]; other site 290315003451 dimer interface [polypeptide binding]; other site 290315003452 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 290315003453 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290315003454 S-adenosylmethionine binding site [chemical binding]; other site 290315003455 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 290315003456 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 290315003457 active site 290315003458 (T/H)XGH motif; other site 290315003459 aspartate aminotransferase; Provisional; Region: PRK05764 290315003460 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290315003461 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290315003462 homodimer interface [polypeptide binding]; other site 290315003463 catalytic residue [active] 290315003464 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 290315003465 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 290315003466 putative acyl-acceptor binding pocket; other site 290315003467 PSP1 C-terminal conserved region; Region: PSP1; pfam04468 290315003468 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 290315003469 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 290315003470 active site 290315003471 HIGH motif; other site 290315003472 KMSKS motif; other site 290315003473 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 290315003474 tRNA binding surface [nucleotide binding]; other site 290315003475 anticodon binding site; other site 290315003476 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 290315003477 dimer interface [polypeptide binding]; other site 290315003478 putative tRNA-binding site [nucleotide binding]; other site 290315003479 Caspase domain; Region: Peptidase_C14; pfam00656 290315003480 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 290315003481 FAD binding domain; Region: FAD_binding_4; pfam01565 290315003482 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 290315003483 Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627 290315003484 putative heme binding site [chemical binding]; other site 290315003485 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 290315003486 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 290315003487 FAD binding pocket [chemical binding]; other site 290315003488 FAD binding motif [chemical binding]; other site 290315003489 phosphate binding motif [ion binding]; other site 290315003490 beta-alpha-beta structure motif; other site 290315003491 NAD binding pocket [chemical binding]; other site 290315003492 Iron coordination center [ion binding]; other site 290315003493 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 290315003494 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 290315003495 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 290315003496 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 290315003497 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 290315003498 Cysteine-rich domain; Region: CCG; pfam02754 290315003499 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 290315003500 Cysteine-rich domain; Region: CCG; pfam02754 290315003501 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 290315003502 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 290315003503 aspartate aminotransferase; Provisional; Region: PRK08636 290315003504 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290315003505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290315003506 homodimer interface [polypeptide binding]; other site 290315003507 catalytic residue [active] 290315003508 Uncharacterized conserved protein [Function unknown]; Region: COG0062 290315003509 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 290315003510 putative substrate binding site [chemical binding]; other site 290315003511 putative ATP binding site [chemical binding]; other site 290315003512 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 290315003513 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 290315003514 dimerization interface [polypeptide binding]; other site 290315003515 ATP binding site [chemical binding]; other site 290315003516 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 290315003517 dimerization interface [polypeptide binding]; other site 290315003518 ATP binding site [chemical binding]; other site 290315003519 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12900 290315003520 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 290315003521 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290315003522 nucleotide binding region [chemical binding]; other site 290315003523 ATP-binding site [chemical binding]; other site 290315003524 SEC-C motif; Region: SEC-C; pfam02810 290315003525 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 290315003526 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 290315003527 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 290315003528 helix-hairpin-helix signature motif; other site 290315003529 substrate binding pocket [chemical binding]; other site 290315003530 active site 290315003531 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 290315003532 NADH(P)-binding; Region: NAD_binding_10; pfam13460 290315003533 NAD(P) binding site [chemical binding]; other site 290315003534 putative active site [active] 290315003535 lipoyl synthase; Provisional; Region: PRK05481 290315003536 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 290315003537 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 290315003538 active site 290315003539 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 290315003540 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 290315003541 P loop; other site 290315003542 Nucleotide binding site [chemical binding]; other site 290315003543 DTAP/Switch II; other site 290315003544 Switch I; other site 290315003545 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 290315003546 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 290315003547 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 290315003548 protein binding site [polypeptide binding]; other site 290315003549 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 290315003550 Catalytic dyad [active] 290315003551 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 290315003552 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 290315003553 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 290315003554 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 290315003555 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 290315003556 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 290315003557 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 290315003558 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_6; cd06256 290315003559 putative active site [active] 290315003560 Zn binding site [ion binding]; other site 290315003561 Repair protein; Region: Repair_PSII; cl01535 290315003562 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 290315003563 Repair protein; Region: Repair_PSII; pfam04536 290315003564 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 290315003565 iron-sulfur cluster [ion binding]; other site 290315003566 [2Fe-2S] cluster binding site [ion binding]; other site 290315003567 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 290315003568 active site 290315003569 FMN binding site [chemical binding]; other site 290315003570 substrate binding site [chemical binding]; other site 290315003571 3Fe-4S cluster binding site [ion binding]; other site 290315003572 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 290315003573 Peptidase family M50; Region: Peptidase_M50; pfam02163 290315003574 active site 290315003575 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 290315003576 putative substrate binding region [chemical binding]; other site 290315003577 CoA binding domain; Region: CoA_binding; smart00881 290315003578 ATP citrate (pro-S)-lyase; Region: PLN02522 290315003579 CoA-ligase; Region: Ligase_CoA; pfam00549 290315003580 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 290315003581 active site 290315003582 oxalacetate binding site [chemical binding]; other site 290315003583 citrylCoA binding site [chemical binding]; other site 290315003584 coenzyme A binding site [chemical binding]; other site 290315003585 catalytic triad [active] 290315003586 Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045 290315003587 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 290315003588 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 290315003589 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 290315003590 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 290315003591 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 290315003592 Walker A/P-loop; other site 290315003593 ATP binding site [chemical binding]; other site 290315003594 Q-loop/lid; other site 290315003595 ABC transporter signature motif; other site 290315003596 Walker B; other site 290315003597 D-loop; other site 290315003598 H-loop/switch region; other site 290315003599 Domain of unknown function DUF87; Region: DUF87; pfam01935 290315003600 Predicted membrane protein [Function unknown]; Region: COG2119 290315003601 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 290315003602 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 290315003603 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 290315003604 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 290315003605 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290315003606 Coenzyme A binding pocket [chemical binding]; other site 290315003607 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 290315003608 Rubredoxin; Region: Rubredoxin; pfam00301 290315003609 iron binding site [ion binding]; other site 290315003610 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 290315003611 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290315003612 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 290315003613 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290315003614 FtsX-like permease family; Region: FtsX; pfam02687 290315003615 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 290315003616 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 290315003617 metal binding site [ion binding]; metal-binding site 290315003618 active site 290315003619 I-site; other site 290315003620 PBP superfamily domain; Region: PBP_like_2; pfam12849 290315003621 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 290315003622 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 290315003623 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 290315003624 heterotetramer interface [polypeptide binding]; other site 290315003625 active site pocket [active] 290315003626 cleavage site 290315003627 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 290315003628 feedback inhibition sensing region; other site 290315003629 homohexameric interface [polypeptide binding]; other site 290315003630 nucleotide binding site [chemical binding]; other site 290315003631 N-acetyl-L-glutamate binding site [chemical binding]; other site 290315003632 ornithine carbamoyltransferase; Provisional; Region: PRK00779 290315003633 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 290315003634 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 290315003635 Arginine repressor [Transcription]; Region: ArgR; COG1438 290315003636 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 290315003637 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 290315003638 argininosuccinate synthase; Provisional; Region: PRK13820 290315003639 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 290315003640 ANP binding site [chemical binding]; other site 290315003641 Substrate Binding Site II [chemical binding]; other site 290315003642 Substrate Binding Site I [chemical binding]; other site 290315003643 argininosuccinate lyase; Provisional; Region: PRK00855 290315003644 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 290315003645 active sites [active] 290315003646 tetramer interface [polypeptide binding]; other site 290315003647 carboxy-terminal protease; Provisional; Region: PRK11186 290315003648 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 290315003649 protein binding site [polypeptide binding]; other site 290315003650 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 290315003651 Catalytic dyad [active] 290315003652 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 290315003653 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 290315003654 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 290315003655 intersubunit interface [polypeptide binding]; other site 290315003656 active site 290315003657 zinc binding site [ion binding]; other site 290315003658 Na+ binding site [ion binding]; other site 290315003659 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 290315003660 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 290315003661 metal binding site [ion binding]; metal-binding site 290315003662 dimer interface [polypeptide binding]; other site 290315003663 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 290315003664 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290315003665 non-specific DNA binding site [nucleotide binding]; other site 290315003666 salt bridge; other site 290315003667 sequence-specific DNA binding site [nucleotide binding]; other site 290315003668 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 290315003669 Catalytic site [active] 290315003670 Transposase IS200 like; Region: Y1_Tnp; cl00848 290315003671 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 290315003672 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 290315003673 polyphosphate kinase; Provisional; Region: PRK05443 290315003674 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 290315003675 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 290315003676 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 290315003677 putative domain interface [polypeptide binding]; other site 290315003678 putative active site [active] 290315003679 catalytic site [active] 290315003680 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 290315003681 putative domain interface [polypeptide binding]; other site 290315003682 putative active site [active] 290315003683 catalytic site [active] 290315003684 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 290315003685 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 290315003686 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 290315003687 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 290315003688 dihydroorotase; Validated; Region: pyrC; PRK09357 290315003689 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290315003690 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 290315003691 active site 290315003692 Methyltransferase domain; Region: Methyltransf_31; pfam13847 290315003693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290315003694 S-adenosylmethionine binding site [chemical binding]; other site 290315003695 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 290315003696 active site 290315003697 catalytic site [active] 290315003698 substrate binding site [chemical binding]; other site 290315003699 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 290315003700 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 290315003701 ligand binding site [chemical binding]; other site 290315003702 flexible hinge region; other site 290315003703 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 290315003704 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 290315003705 metal binding triad; other site 290315003706 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 290315003707 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 290315003708 putative NADP binding site [chemical binding]; other site 290315003709 putative substrate binding site [chemical binding]; other site 290315003710 active site 290315003711 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 290315003712 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 290315003713 ligand binding site [chemical binding]; other site 290315003714 CHAD domain; Region: CHAD; pfam05235 290315003715 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 290315003716 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290315003717 P-loop; other site 290315003718 Magnesium ion binding site [ion binding]; other site 290315003719 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290315003720 Magnesium ion binding site [ion binding]; other site 290315003721 PBP/GOBP family; Region: PBP_GOBP; cl11600 290315003722 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 290315003723 classical (c) SDRs; Region: SDR_c; cd05233 290315003724 NAD(P) binding site [chemical binding]; other site 290315003725 active site 290315003726 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 290315003727 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 290315003728 NlpC/P60 family; Region: NLPC_P60; pfam00877 290315003729 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 290315003730 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 290315003731 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 290315003732 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 290315003733 Walker A/P-loop; other site 290315003734 ATP binding site [chemical binding]; other site 290315003735 Q-loop/lid; other site 290315003736 ABC transporter signature motif; other site 290315003737 Walker B; other site 290315003738 D-loop; other site 290315003739 H-loop/switch region; other site 290315003740 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290315003741 FtsX-like permease family; Region: FtsX; pfam02687 290315003742 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 290315003743 HlyD family secretion protein; Region: HlyD_3; pfam13437 290315003744 putative membrane fusion protein; Region: TIGR02828 290315003745 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 290315003746 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 290315003747 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 290315003748 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 290315003749 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; pfam09603 290315003750 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 290315003751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290315003752 active site 290315003753 phosphorylation site [posttranslational modification] 290315003754 intermolecular recognition site; other site 290315003755 dimerization interface [polypeptide binding]; other site 290315003756 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290315003757 Walker A motif; other site 290315003758 ATP binding site [chemical binding]; other site 290315003759 Walker B motif; other site 290315003760 arginine finger; other site 290315003761 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 290315003762 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 290315003763 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290315003764 putative active site [active] 290315003765 heme pocket [chemical binding]; other site 290315003766 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290315003767 dimer interface [polypeptide binding]; other site 290315003768 phosphorylation site [posttranslational modification] 290315003769 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290315003770 ATP binding site [chemical binding]; other site 290315003771 Mg2+ binding site [ion binding]; other site 290315003772 G-X-G motif; other site 290315003773 Cytochrome c; Region: Cytochrom_C; pfam00034 290315003774 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 290315003775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290315003776 active site 290315003777 phosphorylation site [posttranslational modification] 290315003778 intermolecular recognition site; other site 290315003779 dimerization interface [polypeptide binding]; other site 290315003780 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 290315003781 DNA binding site [nucleotide binding] 290315003782 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290315003783 dimerization interface [polypeptide binding]; other site 290315003784 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290315003785 dimer interface [polypeptide binding]; other site 290315003786 phosphorylation site [posttranslational modification] 290315003787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290315003788 ATP binding site [chemical binding]; other site 290315003789 Mg2+ binding site [ion binding]; other site 290315003790 G-X-G motif; other site 290315003791 putative transposase OrfB; Reviewed; Region: PHA02517 290315003792 HTH-like domain; Region: HTH_21; pfam13276 290315003793 Integrase core domain; Region: rve; pfam00665 290315003794 Integrase core domain; Region: rve_3; pfam13683 290315003795 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 290315003796 Helix-turn-helix domain; Region: HTH_28; pfam13518 290315003797 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 290315003798 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439 290315003799 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 290315003800 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 290315003801 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 290315003802 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 290315003803 HTH-like domain; Region: HTH_21; pfam13276 290315003804 Integrase core domain; Region: rve; pfam00665 290315003805 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 290315003806 Helix-turn-helix domain; Region: HTH_28; pfam13518 290315003807 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 290315003808 Autotransporter beta-domain; Region: Autotransporter; smart00869 290315003809 Winged helix-turn helix; Region: HTH_29; pfam13551 290315003810 Helix-turn-helix domain; Region: HTH_28; pfam13518 290315003811 Winged helix-turn helix; Region: HTH_33; pfam13592 290315003812 DDE superfamily endonuclease; Region: DDE_3; pfam13358 290315003813 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 290315003814 Sel1-like repeats; Region: SEL1; smart00671 290315003815 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 290315003816 Sel1-like repeats; Region: SEL1; smart00671 290315003817 Sel1-like repeats; Region: SEL1; smart00671 290315003818 Sel1-like repeats; Region: SEL1; smart00671 290315003819 Sel1-like repeats; Region: SEL1; smart00671 290315003820 Sel1-like repeats; Region: SEL1; smart00671 290315003821 Sel1-like repeats; Region: SEL1; smart00671 290315003822 Sel1-like repeats; Region: SEL1; smart00671 290315003823 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290315003824 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 290315003825 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 290315003826 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 290315003827 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 290315003828 DsbD alpha interface [polypeptide binding]; other site 290315003829 catalytic residues [active] 290315003830 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 290315003831 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 290315003832 catalytic residues [active] 290315003833 Cupin domain; Region: Cupin_2; pfam07883 290315003834 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290315003835 AAA domain; Region: AAA_23; pfam13476 290315003836 Walker A/P-loop; other site 290315003837 ATP binding site [chemical binding]; other site 290315003838 Q-loop/lid; other site 290315003839 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 290315003840 ABC transporter signature motif; other site 290315003841 Walker B; other site 290315003842 D-loop; other site 290315003843 H-loop/switch region; other site 290315003844 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 290315003845 Malic enzyme, N-terminal domain; Region: malic; pfam00390 290315003846 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 290315003847 putative NAD(P) binding site [chemical binding]; other site 290315003848 exonuclease subunit SbcD; Provisional; Region: PRK10966 290315003849 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 290315003850 active site 290315003851 metal binding site [ion binding]; metal-binding site 290315003852 DNA binding site [nucleotide binding] 290315003853 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 290315003854 Ion channel; Region: Ion_trans_2; pfam07885 290315003855 putative phosphoketolase; Provisional; Region: PRK05261 290315003856 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 290315003857 TPP-binding site; other site 290315003858 XFP C-terminal domain; Region: XFP_C; pfam09363 290315003859 propionate/acetate kinase; Provisional; Region: PRK12379 290315003860 Acetokinase family; Region: Acetate_kinase; cl17229 290315003861 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 290315003862 PemK-like protein; Region: PemK; pfam02452 290315003863 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 290315003864 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 290315003865 Zn binding site [ion binding]; other site 290315003866 Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869 290315003867 peptide binding site [polypeptide binding]; other site 290315003868 toxin interface [polypeptide binding]; other site 290315003869 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 290315003870 YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831 290315003871 Zn binding site [ion binding]; other site 290315003872 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290315003873 non-specific DNA binding site [nucleotide binding]; other site 290315003874 salt bridge; other site 290315003875 sequence-specific DNA binding site [nucleotide binding]; other site 290315003876 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 290315003877 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 290315003878 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 290315003879 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 290315003880 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 290315003881 PemK-like protein; Region: PemK; pfam02452 290315003882 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 290315003883 PemK-like protein; Region: PemK; pfam02452 290315003884 Predicted transcriptional regulator [General function prediction only]; Region: COG2522 290315003885 DEAD-like helicases superfamily; Region: DEXDc; smart00487 290315003886 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290315003887 ATP binding site [chemical binding]; other site 290315003888 putative Mg++ binding site [ion binding]; other site 290315003889 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 290315003890 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290315003891 nucleotide binding region [chemical binding]; other site 290315003892 ATP-binding site [chemical binding]; other site 290315003893 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 290315003894 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 290315003895 Transposase IS200 like; Region: Y1_Tnp; cl00848 290315003896 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 290315003897 AAA domain; Region: AAA_30; pfam13604 290315003898 Family description; Region: UvrD_C_2; pfam13538 290315003899 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 290315003900 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 290315003901 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 290315003902 Bacterial PH domain; Region: DUF304; pfam03703 290315003903 Domain of unknown function (DUF389); Region: DUF389; pfam04087 290315003904 Protein of unknown function (DUF2379); Region: DUF2379; cl15283 290315003905 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 290315003906 serpin-like protein; Provisional; Region: PHA02660 290315003907 reactive center loop; other site 290315003908 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 290315003909 DNA photolyase; Region: DNA_photolyase; pfam00875 290315003910 HTH domain; Region: HTH_11; cl17392 290315003911 Domain of unknown function (DUF4403); Region: DUF4403; pfam14356 290315003912 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 290315003913 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290315003914 sequence-specific DNA binding site [nucleotide binding]; other site 290315003915 salt bridge; other site 290315003916 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 290315003917 RmuC family; Region: RmuC; pfam02646 290315003918 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 290315003919 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 290315003920 methionine sulfoxide reductase A; Provisional; Region: PRK14054 290315003921 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 290315003922 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 290315003923 catalytic residues [active] 290315003924 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 290315003925 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290315003926 ATP-grasp domain; Region: ATP-grasp_4; cl17255 290315003927 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 290315003928 oxaloacetate decarboxylase alpha subunit; Region: oadA; TIGR01108 290315003929 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 290315003930 active site 290315003931 catalytic residues [active] 290315003932 metal binding site [ion binding]; metal-binding site 290315003933 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 290315003934 carboxyltransferase (CT) interaction site; other site 290315003935 biotinylation site [posttranslational modification]; other site 290315003936 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 290315003937 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 290315003938 TPP-binding site [chemical binding]; other site 290315003939 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 290315003940 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 290315003941 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 290315003942 E3 interaction surface; other site 290315003943 lipoyl attachment site [posttranslational modification]; other site 290315003944 e3 binding domain; Region: E3_binding; pfam02817 290315003945 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 290315003946 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 290315003947 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290315003948 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 290315003949 Staphylococcal nuclease homologues; Region: SNc; smart00318 290315003950 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 290315003951 Catalytic site; other site 290315003952 von Willebrand factor type A domain; Region: VWA_2; pfam13519 290315003953 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 290315003954 putative hydrophobic ligand binding site [chemical binding]; other site 290315003955 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 290315003956 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 290315003957 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 290315003958 inhibitor-cofactor binding pocket; inhibition site 290315003959 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290315003960 catalytic residue [active] 290315003961 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 290315003962 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 290315003963 active site 290315003964 NAD binding site [chemical binding]; other site 290315003965 metal binding site [ion binding]; metal-binding site 290315003966 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 290315003967 ligand binding site; other site 290315003968 tetramer interface; other site 290315003969 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290315003970 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290315003971 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 290315003972 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 290315003973 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 290315003974 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 290315003975 acyl-activating enzyme (AAE) consensus motif; other site 290315003976 putative AMP binding site [chemical binding]; other site 290315003977 putative active site [active] 290315003978 putative CoA binding site [chemical binding]; other site 290315003979 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 290315003980 endonuclease III; Region: ENDO3c; smart00478 290315003981 minor groove reading motif; other site 290315003982 helix-hairpin-helix signature motif; other site 290315003983 substrate binding pocket [chemical binding]; other site 290315003984 active site 290315003985 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 290315003986 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 290315003987 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 290315003988 16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273 290315003989 RimM N-terminal domain; Region: RimM; pfam01782 290315003990 PRC-barrel domain; Region: PRC; pfam05239 290315003991 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 290315003992 signal recognition particle protein; Provisional; Region: PRK10867 290315003993 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 290315003994 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 290315003995 P loop; other site 290315003996 GTP binding site [chemical binding]; other site 290315003997 Signal peptide binding domain; Region: SRP_SPB; pfam02978 290315003998 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 290315003999 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 290315004000 putative ribose interaction site [chemical binding]; other site 290315004001 putative ADP binding site [chemical binding]; other site 290315004002 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 290315004003 putative lipid binding site [chemical binding]; other site 290315004004 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 290315004005 putative lipid binding site [chemical binding]; other site 290315004006 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 290315004007 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 290315004008 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 290315004009 protein binding site [polypeptide binding]; other site 290315004010 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 290315004011 Catalytic dyad [active] 290315004012 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 290315004013 homotrimer interaction site [polypeptide binding]; other site 290315004014 putative active site [active] 290315004015 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 290315004016 thiamine phosphate binding site [chemical binding]; other site 290315004017 active site 290315004018 pyrophosphate binding site [ion binding]; other site 290315004019 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 290315004020 thiamine phosphate binding site [chemical binding]; other site 290315004021 active site 290315004022 pyrophosphate binding site [ion binding]; other site 290315004023 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 290315004024 dimer interface [polypeptide binding]; other site 290315004025 substrate binding site [chemical binding]; other site 290315004026 ATP binding site [chemical binding]; other site 290315004027 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 290315004028 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 290315004029 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 290315004030 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 290315004031 Biogenesis of lysosome-related organelles complex-1 subunit 2; Region: BLOC1_2; pfam10046 290315004032 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 290315004033 multifunctional aminopeptidase A; Provisional; Region: PRK00913 290315004034 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 290315004035 interface (dimer of trimers) [polypeptide binding]; other site 290315004036 Substrate-binding/catalytic site; other site 290315004037 Zn-binding sites [ion binding]; other site 290315004038 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 290315004039 DHH family; Region: DHH; pfam01368 290315004040 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 290315004041 Transcriptional regulators [Transcription]; Region: MarR; COG1846 290315004042 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14456 290315004043 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290315004044 FeS/SAM binding site; other site 290315004045 adenylate kinase; Reviewed; Region: adk; PRK00279 290315004046 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 290315004047 AMP-binding site [chemical binding]; other site 290315004048 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 290315004049 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 290315004050 primosomal protein N' Region: priA; TIGR00595 290315004051 ATP binding site [chemical binding]; other site 290315004052 putative Mg++ binding site [ion binding]; other site 290315004053 helicase superfamily c-terminal domain; Region: HELICc; smart00490 290315004054 ATP-binding site [chemical binding]; other site 290315004055 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 290315004056 HlyD family secretion protein; Region: HlyD_3; pfam13437 290315004057 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 290315004058 FtsX-like permease family; Region: FtsX; pfam02687 290315004059 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 290315004060 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290315004061 FtsX-like permease family; Region: FtsX; pfam02687 290315004062 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 290315004063 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 290315004064 Walker A/P-loop; other site 290315004065 ATP binding site [chemical binding]; other site 290315004066 Q-loop/lid; other site 290315004067 ABC transporter signature motif; other site 290315004068 Walker B; other site 290315004069 D-loop; other site 290315004070 H-loop/switch region; other site 290315004071 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 290315004072 SET domain; Region: SET; pfam00856 290315004073 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 290315004074 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 290315004075 putative active site [active] 290315004076 metal binding site [ion binding]; metal-binding site 290315004077 Predicted DNA-binding proteins [General function prediction only]; Region: COG1342 290315004078 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 290315004079 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323 290315004080 gating phenylalanine in ion channel; other site 290315004081 OsmC-like protein; Region: OsmC; pfam02566 290315004082 flavoprotein, HI0933 family; Region: TIGR00275 290315004083 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290315004084 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 290315004085 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 290315004086 MASE1; Region: MASE1; cl17823 290315004087 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 290315004088 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 290315004089 E3 interaction surface; other site 290315004090 lipoyl attachment site [posttranslational modification]; other site 290315004091 HlyD family secretion protein; Region: HlyD_3; pfam13437 290315004092 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 290315004093 Helix-turn-helix domain; Region: HTH_18; pfam12833 290315004094 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 290315004095 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 290315004096 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 290315004097 DNA binding site [nucleotide binding] 290315004098 active site 290315004099 Protein of unknown function (DUF1847); Region: DUF1847; pfam08901 290315004100 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 290315004101 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 290315004102 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 290315004103 FMN binding site [chemical binding]; other site 290315004104 active site 290315004105 substrate binding site [chemical binding]; other site 290315004106 catalytic residue [active] 290315004107 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 290315004108 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 290315004109 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 290315004110 UbiA prenyltransferase family; Region: UbiA; pfam01040 290315004111 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 290315004112 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 290315004113 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290315004114 active site residue [active] 290315004115 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 290315004116 active site 290315004117 catalytic site [active] 290315004118 substrate binding site [chemical binding]; other site 290315004119 heat shock protein HtpX; Provisional; Region: PRK05457 290315004120 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 290315004121 active site 290315004122 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290315004123 FeS/SAM binding site; other site 290315004124 Radical SAM superfamily; Region: Radical_SAM; pfam04055 290315004125 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 290315004126 Putative methyltransferase; Region: Methyltransf_4; cl17290 290315004127 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 290315004128 Radical SAM superfamily; Region: Radical_SAM; pfam04055 290315004129 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290315004130 FeS/SAM binding site; other site 290315004131 Transposase [DNA replication, recombination, and repair]; Region: COG5421 290315004132 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 290315004133 putative active site [active] 290315004134 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 290315004135 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 290315004136 TIGR02646 family protein; Region: TIGR02646 290315004137 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 290315004138 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290315004139 Walker A/P-loop; other site 290315004140 ATP binding site [chemical binding]; other site 290315004141 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 290315004142 DNA methylase; Region: N6_N4_Mtase; pfam01555 290315004143 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 290315004144 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 290315004145 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 290315004146 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 290315004147 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 290315004148 Protein of unknown function DUF86; Region: DUF86; pfam01934 290315004149 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 290315004150 active site 290315004151 NTP binding site [chemical binding]; other site 290315004152 metal binding triad [ion binding]; metal-binding site 290315004153 antibiotic binding site [chemical binding]; other site 290315004154 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 290315004155 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 290315004156 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 290315004157 HipA N-terminal domain; Region: Couple_hipA; pfam13657 290315004158 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 290315004159 HipA-like N-terminal domain; Region: HipA_N; pfam07805 290315004160 HipA-like C-terminal domain; Region: HipA_C; pfam07804 290315004161 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 290315004162 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 290315004163 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 290315004164 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 290315004165 G1 box; other site 290315004166 GTP/Mg2+ binding site [chemical binding]; other site 290315004167 G2 box; other site 290315004168 Switch I region; other site 290315004169 G3 box; other site 290315004170 Switch II region; other site 290315004171 TIR domain; Region: TIR_2; pfam13676 290315004172 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290315004173 non-specific DNA binding site [nucleotide binding]; other site 290315004174 salt bridge; other site 290315004175 sequence-specific DNA binding site [nucleotide binding]; other site 290315004176 Winged helix-turn helix; Region: HTH_29; pfam13551 290315004177 Helix-turn-helix domain; Region: HTH_28; pfam13518 290315004178 Winged helix-turn helix; Region: HTH_33; pfam13592 290315004179 DDE superfamily endonuclease; Region: DDE_3; pfam13358 290315004180 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 290315004181 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 290315004182 MPN+ (JAMM) motif; other site 290315004183 Zinc-binding site [ion binding]; other site 290315004184 Helix-turn-helix domain; Region: HTH_19; pfam12844 290315004185 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 290315004186 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 290315004187 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 290315004188 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 290315004189 active site 290315004190 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 290315004191 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 290315004192 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 290315004193 magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031 290315004194 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 290315004195 metal ion-dependent adhesion site (MIDAS); other site 290315004196 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 290315004197 AAA ATPase domain; Region: AAA_16; pfam13191 290315004198 Walker A motif; other site 290315004199 ATP binding site [chemical binding]; other site 290315004200 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 290315004201 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290315004202 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 290315004203 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 290315004204 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290315004205 RNA binding surface [nucleotide binding]; other site 290315004206 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 290315004207 active site 290315004208 YXWGXW repeat (2 copies); Region: YXWGXW; pfam12779 290315004209 YXWGXW repeat (2 copies); Region: YXWGXW; pfam12779 290315004210 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 290315004211 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 290315004212 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 290315004213 A new structural DNA glycosylase; Region: AlkD_like; cd06561 290315004214 active site 290315004215 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 290315004216 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290315004217 Walker A/P-loop; other site 290315004218 ATP binding site [chemical binding]; other site 290315004219 Q-loop/lid; other site 290315004220 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290315004221 ABC transporter signature motif; other site 290315004222 Walker B; other site 290315004223 D-loop; other site 290315004224 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290315004225 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 290315004226 PAS domain S-box; Region: sensory_box; TIGR00229 290315004227 PAS domain; Region: PAS_8; pfam13188 290315004228 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290315004229 putative active site [active] 290315004230 heme pocket [chemical binding]; other site 290315004231 PAS domain S-box; Region: sensory_box; TIGR00229 290315004232 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290315004233 putative active site [active] 290315004234 heme pocket [chemical binding]; other site 290315004235 PAS domain S-box; Region: sensory_box; TIGR00229 290315004236 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290315004237 putative active site [active] 290315004238 heme pocket [chemical binding]; other site 290315004239 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 290315004240 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290315004241 putative active site [active] 290315004242 heme pocket [chemical binding]; other site 290315004243 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290315004244 dimer interface [polypeptide binding]; other site 290315004245 phosphorylation site [posttranslational modification] 290315004246 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290315004247 ATP binding site [chemical binding]; other site 290315004248 Mg2+ binding site [ion binding]; other site 290315004249 G-X-G motif; other site 290315004250 Response regulator receiver domain; Region: Response_reg; pfam00072 290315004251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290315004252 active site 290315004253 phosphorylation site [posttranslational modification] 290315004254 intermolecular recognition site; other site 290315004255 dimerization interface [polypeptide binding]; other site 290315004256 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 290315004257 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290315004258 NAD(P) binding site [chemical binding]; other site 290315004259 active site 290315004260 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 290315004261 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 290315004262 thymidylate kinase; Validated; Region: tmk; PRK00698 290315004263 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 290315004264 TMP-binding site; other site 290315004265 ATP-binding site [chemical binding]; other site 290315004266 phosphoglycolate phosphatase; Provisional; Region: PRK01158 290315004267 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 290315004268 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290315004269 motif II; other site 290315004270 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 290315004271 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 290315004272 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 290315004273 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 290315004274 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 290315004275 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 290315004276 substrate binding site; other site 290315004277 dimer interface; other site 290315004278 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 290315004279 CoenzymeA binding site [chemical binding]; other site 290315004280 subunit interaction site [polypeptide binding]; other site 290315004281 PHB binding site; other site 290315004282 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 290315004283 B12 binding site [chemical binding]; other site 290315004284 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 290315004285 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290315004286 FeS/SAM binding site; other site 290315004287 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 290315004288 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 290315004289 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 290315004290 dimer interface [polypeptide binding]; other site 290315004291 anticodon binding site; other site 290315004292 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 290315004293 homodimer interface [polypeptide binding]; other site 290315004294 motif 1; other site 290315004295 active site 290315004296 motif 2; other site 290315004297 GAD domain; Region: GAD; pfam02938 290315004298 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 290315004299 active site 290315004300 motif 3; other site 290315004301 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 290315004302 ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214 290315004303 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 290315004304 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 290315004305 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 290315004306 putative active site [active] 290315004307 catalytic triad [active] 290315004308 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 290315004309 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 290315004310 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 290315004311 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 290315004312 oligomerization interface [polypeptide binding]; other site 290315004313 active site 290315004314 metal binding site [ion binding]; metal-binding site 290315004315 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 290315004316 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 290315004317 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 290315004318 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 290315004319 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 290315004320 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 290315004321 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 290315004322 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 290315004323 HlyD family secretion protein; Region: HlyD_3; pfam13437 290315004324 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 290315004325 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 290315004326 Walker A/P-loop; other site 290315004327 ATP binding site [chemical binding]; other site 290315004328 Q-loop/lid; other site 290315004329 ABC transporter signature motif; other site 290315004330 Walker B; other site 290315004331 D-loop; other site 290315004332 H-loop/switch region; other site 290315004333 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290315004334 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 290315004335 FtsX-like permease family; Region: FtsX; pfam02687 290315004336 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290315004337 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 290315004338 FtsX-like permease family; Region: FtsX; pfam02687 290315004339 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 290315004340 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 290315004341 ligand binding site [chemical binding]; other site 290315004342 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 290315004343 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 290315004344 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 290315004345 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 290315004346 trimer interface [polypeptide binding]; other site 290315004347 active site 290315004348 UDP-GlcNAc binding site [chemical binding]; other site 290315004349 lipid binding site [chemical binding]; lipid-binding site 290315004350 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 290315004351 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 290315004352 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290315004353 active site 290315004354 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 290315004355 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 290315004356 5S rRNA interface [nucleotide binding]; other site 290315004357 CTC domain interface [polypeptide binding]; other site 290315004358 L16 interface [polypeptide binding]; other site 290315004359 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 290315004360 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 290315004361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290315004362 dimer interface [polypeptide binding]; other site 290315004363 conserved gate region; other site 290315004364 putative PBP binding loops; other site 290315004365 ABC-ATPase subunit interface; other site 290315004366 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 290315004367 dimer interface [polypeptide binding]; other site 290315004368 ADP-ribose binding site [chemical binding]; other site 290315004369 active site 290315004370 nudix motif; other site 290315004371 metal binding site [ion binding]; metal-binding site 290315004372 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 290315004373 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 290315004374 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290315004375 Walker A motif; other site 290315004376 ATP binding site [chemical binding]; other site 290315004377 Walker B motif; other site 290315004378 arginine finger; other site 290315004379 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 290315004380 Competence protein; Region: Competence; pfam03772 290315004381 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 290315004382 FAD binding site [chemical binding]; other site 290315004383 diaminopimelate decarboxylase; Region: lysA; TIGR01048 290315004384 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 290315004385 active site 290315004386 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 290315004387 substrate binding site [chemical binding]; other site 290315004388 catalytic residues [active] 290315004389 dimer interface [polypeptide binding]; other site 290315004390 ribosomal protein L33; Region: rpl33; CHL00104 290315004391 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 290315004392 Putative zinc ribbon domain; Region: DUF164; pfam02591 290315004393 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 290315004394 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 290315004395 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290315004396 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290315004397 homodimer interface [polypeptide binding]; other site 290315004398 catalytic residue [active] 290315004399 Protein of unknown function (DUF456); Region: DUF456; pfam04306 290315004400 Transposase [DNA replication, recombination, and repair]; Region: COG5421 290315004401 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 290315004402 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 290315004403 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 290315004404 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 290315004405 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 290315004406 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 290315004407 FeoA domain; Region: FeoA; pfam04023 290315004408 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 290315004409 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 290315004410 putative active site [active] 290315004411 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 290315004412 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 290315004413 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 290315004414 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 290315004415 putative active site [active] 290315004416 Transposase domain (DUF772); Region: DUF772; pfam05598 290315004417 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 290315004418 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 290315004419 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 290315004420 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 290315004421 Walker A/P-loop; other site 290315004422 ATP binding site [chemical binding]; other site 290315004423 Q-loop/lid; other site 290315004424 ABC transporter signature motif; other site 290315004425 Walker B; other site 290315004426 D-loop; other site 290315004427 H-loop/switch region; other site 290315004428 Transposase domain (DUF772); Region: DUF772; pfam05598 290315004429 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 290315004430 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 290315004431 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 290315004432 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 290315004433 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 290315004434 catalytic loop [active] 290315004435 iron binding site [ion binding]; other site 290315004436 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 290315004437 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 290315004438 probable rRNA maturation factor YbeY; Region: TIGR00043 290315004439 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 290315004440 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 290315004441 HflX GTPase family; Region: HflX; cd01878 290315004442 G1 box; other site 290315004443 GTP/Mg2+ binding site [chemical binding]; other site 290315004444 Switch I region; other site 290315004445 G2 box; other site 290315004446 G3 box; other site 290315004447 Switch II region; other site 290315004448 G4 box; other site 290315004449 G5 box; other site 290315004450 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 290315004451 active site lid residues [active] 290315004452 substrate binding pocket [chemical binding]; other site 290315004453 catalytic residues [active] 290315004454 substrate-Mg2+ binding site; other site 290315004455 aspartate-rich region 1; other site 290315004456 aspartate-rich region 2; other site 290315004457 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 290315004458 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 290315004459 dimer interface [polypeptide binding]; other site 290315004460 putative anticodon binding site; other site 290315004461 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 290315004462 motif 1; other site 290315004463 active site 290315004464 motif 2; other site 290315004465 motif 3; other site 290315004466 Divergent AAA domain; Region: AAA_4; pfam04326 290315004467 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290315004468 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 290315004469 putative NAD(P) binding site [chemical binding]; other site 290315004470 active site 290315004471 putative substrate binding site [chemical binding]; other site 290315004472 transcriptional activator RfaH; Region: RfaH; TIGR01955 290315004473 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), TaA; Region: NGN_SP_TaA; cd09893 290315004474 KOW (Kyprides, Ouzounis, Woese) motif; Region: KOW; smart00739 290315004475 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290315004476 TPR motif; other site 290315004477 TPR repeat; Region: TPR_11; pfam13414 290315004478 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 290315004479 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 290315004480 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 290315004481 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 290315004482 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290315004483 FeS/SAM binding site; other site 290315004484 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 290315004485 DNA methylase; Region: N6_N4_Mtase; pfam01555 290315004486 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 290315004487 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290315004488 Walker A motif; other site 290315004489 ATP binding site [chemical binding]; other site 290315004490 Walker B motif; other site 290315004491 arginine finger; other site 290315004492 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 290315004493 Integrase core domain; Region: rve; pfam00665 290315004494 Hemerythrin-like domain; Region: Hr-like; cd12108 290315004495 Fe binding site [ion binding]; other site 290315004496 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290315004497 PAS domain; Region: PAS_9; pfam13426 290315004498 putative active site [active] 290315004499 heme pocket [chemical binding]; other site 290315004500 Transcriptional regulators [Transcription]; Region: MarR; COG1846 290315004501 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 290315004502 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 290315004503 CheB methylesterase; Region: CheB_methylest; pfam01339 290315004504 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 290315004505 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 290315004506 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 290315004507 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 290315004508 PAS domain; Region: PAS_10; pfam13596 290315004509 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290315004510 putative active site [active] 290315004511 heme pocket [chemical binding]; other site 290315004512 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 290315004513 patatin-related protein; Region: TIGR03607 290315004514 Patatin-like phospholipase; Region: Patatin; pfam01734 290315004515 nucleophile elbow; other site 290315004516 HEPN domain; Region: HEPN; cl00824 290315004517 Protein of unknown function (DUF3376); Region: DUF3376; pfam11856 290315004518 amino acid transporter; Region: 2A0306; TIGR00909 290315004519 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 290315004520 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 290315004521 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 290315004522 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290315004523 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 290315004524 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290315004525 motif II; other site 290315004526 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 290315004527 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 290315004528 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 290315004529 FAD binding domain; Region: FAD_binding_4; pfam01565 290315004530 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 290315004531 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 290315004532 Cysteine-rich domain; Region: CCG; pfam02754 290315004533 Cysteine-rich domain; Region: CCG; pfam02754 290315004534 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 290315004535 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 290315004536 classical (c) SDRs; Region: SDR_c; cd05233 290315004537 NAD(P) binding site [chemical binding]; other site 290315004538 active site 290315004539 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 290315004540 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 290315004541 active site 290315004542 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 290315004543 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 290315004544 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 290315004545 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 290315004546 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 290315004547 DoxX-like family; Region: DoxX_3; pfam13781 290315004548 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 290315004549 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 290315004550 HlyD family secretion protein; Region: HlyD_3; pfam13437 290315004551 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 290315004552 PhoU domain; Region: PhoU; pfam01895 290315004553 PhoU domain; Region: PhoU; pfam01895 290315004554 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 290315004555 PhoU domain; Region: PhoU; pfam01895 290315004556 PhoU domain; Region: PhoU; pfam01895 290315004557 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14275 290315004558 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 290315004559 Walker A/P-loop; other site 290315004560 ATP binding site [chemical binding]; other site 290315004561 Q-loop/lid; other site 290315004562 ABC transporter signature motif; other site 290315004563 Walker B; other site 290315004564 D-loop; other site 290315004565 H-loop/switch region; other site 290315004566 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 290315004567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290315004568 dimer interface [polypeptide binding]; other site 290315004569 conserved gate region; other site 290315004570 putative PBP binding loops; other site 290315004571 ABC-ATPase subunit interface; other site 290315004572 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 290315004573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 290315004574 dimer interface [polypeptide binding]; other site 290315004575 conserved gate region; other site 290315004576 putative PBP binding loops; other site 290315004577 ABC-ATPase subunit interface; other site 290315004578 PBP superfamily domain; Region: PBP_like_2; cl17296 290315004579 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 290315004580 PBP superfamily domain; Region: PBP_like_2; cl17296 290315004581 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 290315004582 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 290315004583 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 290315004584 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 290315004585 putative acyl-acceptor binding pocket; other site 290315004586 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 290315004587 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 290315004588 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 290315004589 Predicted permeases [General function prediction only]; Region: COG0795 290315004590 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 290315004591 four helix bundle suffix domain; Region: 4helix_suffix; TIGR04258 290315004592 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 290315004593 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 290315004594 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 290315004595 4-fold oligomerization interface [polypeptide binding]; other site 290315004596 putative active site pocket [active] 290315004597 metal binding residues [ion binding]; metal-binding site 290315004598 3-fold/trimer interface [polypeptide binding]; other site 290315004599 phosphodiesterase; Provisional; Region: PRK12704 290315004600 KH domain; Region: KH_1; pfam00013 290315004601 uncharacterized domain HDIG; Region: HDIG; TIGR00277 290315004602 Cell division protein ZapA; Region: ZapA; pfam05164 290315004603 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 290315004604 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 290315004605 putative tRNA-binding site [nucleotide binding]; other site 290315004606 B3/4 domain; Region: B3_4; pfam03483 290315004607 tRNA synthetase B5 domain; Region: B5; smart00874 290315004608 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 290315004609 dimer interface [polypeptide binding]; other site 290315004610 motif 1; other site 290315004611 motif 3; other site 290315004612 motif 2; other site 290315004613 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 290315004614 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 290315004615 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 290315004616 HlyD family secretion protein; Region: HlyD_3; pfam13437 290315004617 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 290315004618 nudix motif; other site 290315004619 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290315004620 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 290315004621 active site 290315004622 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 290315004623 putative trimer interface [polypeptide binding]; other site 290315004624 putative CoA binding site [chemical binding]; other site 290315004625 S-adenosylmethionine synthetase; Validated; Region: PRK05250 290315004626 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 290315004627 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 290315004628 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 290315004629 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 290315004630 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 290315004631 homotetramer interface [polypeptide binding]; other site 290315004632 ligand binding site [chemical binding]; other site 290315004633 catalytic site [active] 290315004634 NAD binding site [chemical binding]; other site 290315004635 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 290315004636 active site 290315004637 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 290315004638 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 290315004639 TAP-like protein; Region: Abhydrolase_4; pfam08386 290315004640 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 290315004641 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 290315004642 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 290315004643 TrkA-N domain; Region: TrkA_N; pfam02254 290315004644 Rubrerythrin [Energy production and conversion]; Region: COG1592 290315004645 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 290315004646 binuclear metal center [ion binding]; other site 290315004647 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 290315004648 iron binding site [ion binding]; other site 290315004649 cyclase homology domain; Region: CHD; cd07302 290315004650 nucleotidyl binding site; other site 290315004651 metal binding site [ion binding]; metal-binding site 290315004652 dimer interface [polypeptide binding]; other site 290315004653 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 290315004654 putative transporter; Provisional; Region: PRK11660 290315004655 Sulfate transporter family; Region: Sulfate_transp; pfam00916 290315004656 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 290315004657 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 290315004658 ArsC family; Region: ArsC; pfam03960 290315004659 putative catalytic residues [active] 290315004660 TspO/MBR family; Region: TspO_MBR; pfam03073 290315004661 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 290315004662 trimer interface [polypeptide binding]; other site 290315004663 putative Zn binding site [ion binding]; other site 290315004664 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 290315004665 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 290315004666 hexamer interface [polypeptide binding]; other site 290315004667 ligand binding site [chemical binding]; other site 290315004668 putative active site [active] 290315004669 NAD(P) binding site [chemical binding]; other site 290315004670 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290315004671 Protein of unknown function DUF45; Region: DUF45; pfam01863 290315004672 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 290315004673 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 290315004674 HlyD family secretion protein; Region: HlyD_3; pfam13437 290315004675 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 290315004676 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 290315004677 ligand binding site [chemical binding]; other site 290315004678 flexible hinge region; other site 290315004679 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 290315004680 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 290315004681 putative active site [active] 290315004682 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290315004683 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290315004684 Walker A/P-loop; other site 290315004685 ATP binding site [chemical binding]; other site 290315004686 Q-loop/lid; other site 290315004687 ABC transporter signature motif; other site 290315004688 Walker B; other site 290315004689 D-loop; other site 290315004690 H-loop/switch region; other site 290315004691 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 290315004692 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004693 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004694 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004695 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004696 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004697 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004698 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004699 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004700 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004701 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004702 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004703 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004704 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004705 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004706 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004707 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004708 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004709 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004710 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004711 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004712 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004713 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004714 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004715 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004716 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004717 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004718 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004719 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004720 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004721 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004722 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004723 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004724 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004725 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 290315004726 metal ion-dependent adhesion site (MIDAS); other site 290315004727 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 290315004728 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 290315004729 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004730 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004731 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004732 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004733 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004734 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004735 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004736 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004737 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004738 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004739 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004740 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 290315004741 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 290315004742 metal ion-dependent adhesion site (MIDAS); other site 290315004743 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 290315004744 active site 290315004745 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 290315004746 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290315004747 FeS/SAM binding site; other site 290315004748 PUCC protein; Region: PUCC; pfam03209 290315004749 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 290315004750 ThiC-associated domain; Region: ThiC-associated; pfam13667 290315004751 ThiC family; Region: ThiC; pfam01964 290315004752 triosephosphate isomerase; Provisional; Region: PRK14567 290315004753 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 290315004754 substrate binding site [chemical binding]; other site 290315004755 dimer interface [polypeptide binding]; other site 290315004756 catalytic triad [active] 290315004757 Sm and related proteins; Region: Sm_like; cl00259 290315004758 heptamer interface [polypeptide binding]; other site 290315004759 Sm1 motif; other site 290315004760 hexamer interface [polypeptide binding]; other site 290315004761 RNA binding site [nucleotide binding]; other site 290315004762 Sm2 motif; other site 290315004763 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 290315004764 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 290315004765 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 290315004766 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 290315004767 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 290315004768 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 290315004769 protein binding site [polypeptide binding]; other site 290315004770 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 290315004771 protein binding site [polypeptide binding]; other site 290315004772 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 290315004773 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 290315004774 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 290315004775 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 290315004776 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 290315004777 Catalytic site [active] 290315004778 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 290315004779 GTP-binding protein LepA; Provisional; Region: PRK05433 290315004780 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 290315004781 G1 box; other site 290315004782 putative GEF interaction site [polypeptide binding]; other site 290315004783 GTP/Mg2+ binding site [chemical binding]; other site 290315004784 Switch I region; other site 290315004785 G2 box; other site 290315004786 G3 box; other site 290315004787 Switch II region; other site 290315004788 G4 box; other site 290315004789 G5 box; other site 290315004790 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 290315004791 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 290315004792 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 290315004793 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 290315004794 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 290315004795 putative active site [active] 290315004796 substrate binding site [chemical binding]; other site 290315004797 putative cosubstrate binding site; other site 290315004798 catalytic site [active] 290315004799 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 290315004800 substrate binding site [chemical binding]; other site 290315004801 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 290315004802 active site 290315004803 catalytic residues [active] 290315004804 metal binding site [ion binding]; metal-binding site 290315004805 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 290315004806 metal binding site 2 [ion binding]; metal-binding site 290315004807 putative DNA binding helix; other site 290315004808 metal binding site 1 [ion binding]; metal-binding site 290315004809 dimer interface [polypeptide binding]; other site 290315004810 structural Zn2+ binding site [ion binding]; other site 290315004811 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 290315004812 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 290315004813 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 290315004814 Ligand Binding Site [chemical binding]; other site 290315004815 gamma-glutamyl kinase; Provisional; Region: PRK05429 290315004816 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 290315004817 nucleotide binding site [chemical binding]; other site 290315004818 homotetrameric interface [polypeptide binding]; other site 290315004819 putative phosphate binding site [ion binding]; other site 290315004820 putative allosteric binding site; other site 290315004821 PUA domain; Region: PUA; pfam01472 290315004822 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 290315004823 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 290315004824 putative catalytic cysteine [active] 290315004825 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 290315004826 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 290315004827 Walker A/P-loop; other site 290315004828 ATP binding site [chemical binding]; other site 290315004829 Q-loop/lid; other site 290315004830 ABC transporter signature motif; other site 290315004831 Walker B; other site 290315004832 D-loop; other site 290315004833 H-loop/switch region; other site 290315004834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 290315004835 Major Facilitator Superfamily; Region: MFS_1; pfam07690 290315004836 putative substrate translocation pore; other site 290315004837 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 290315004838 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 290315004839 inhibitor-cofactor binding pocket; inhibition site 290315004840 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290315004841 catalytic residue [active] 290315004842 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 290315004843 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 290315004844 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290315004845 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290315004846 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 290315004847 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 290315004848 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 290315004849 Flavodoxin domain; Region: Flavodoxin_5; cl17428 290315004850 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 290315004851 chaperone protein DnaJ; Provisional; Region: PRK14281 290315004852 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 290315004853 HSP70 interaction site [polypeptide binding]; other site 290315004854 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 290315004855 Zn binding sites [ion binding]; other site 290315004856 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 290315004857 dimer interface [polypeptide binding]; other site 290315004858 GrpE; Region: GrpE; pfam01025 290315004859 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 290315004860 dimer interface [polypeptide binding]; other site 290315004861 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 290315004862 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 290315004863 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 290315004864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290315004865 S-adenosylmethionine binding site [chemical binding]; other site 290315004866 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 290315004867 prolyl-tRNA synthetase; Provisional; Region: PRK08661 290315004868 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 290315004869 dimer interface [polypeptide binding]; other site 290315004870 motif 1; other site 290315004871 active site 290315004872 motif 2; other site 290315004873 motif 3; other site 290315004874 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 290315004875 anticodon binding site; other site 290315004876 zinc-binding site [ion binding]; other site 290315004877 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 290315004878 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 290315004879 dimer interface [polypeptide binding]; other site 290315004880 decamer (pentamer of dimers) interface [polypeptide binding]; other site 290315004881 catalytic triad [active] 290315004882 peroxidatic and resolving cysteines [active] 290315004883 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 290315004884 Predicted amidohydrolase [General function prediction only]; Region: COG0388 290315004885 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_8; cd07586 290315004886 putative active site [active] 290315004887 catalytic triad [active] 290315004888 putative dimer interface [polypeptide binding]; other site 290315004889 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14616 290315004890 Sporulation related domain; Region: SPOR; pfam05036 290315004891 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 290315004892 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290315004893 Walker A motif; other site 290315004894 ATP binding site [chemical binding]; other site 290315004895 Walker B motif; other site 290315004896 arginine finger; other site 290315004897 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 290315004898 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 290315004899 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 290315004900 putative active site [active] 290315004901 catalytic triad [active] 290315004902 putative dimer interface [polypeptide binding]; other site 290315004903 Bacteriochlorophyll A protein; Region: BChl_A; pfam02327 290315004904 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 290315004905 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 290315004906 DNA binding residues [nucleotide binding] 290315004907 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 290315004908 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290315004909 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290315004910 Walker A/P-loop; other site 290315004911 ATP binding site [chemical binding]; other site 290315004912 Q-loop/lid; other site 290315004913 ABC transporter signature motif; other site 290315004914 Walker B; other site 290315004915 D-loop; other site 290315004916 H-loop/switch region; other site 290315004917 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 290315004918 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 290315004919 ATP-grasp domain; Region: ATP-grasp; pfam02222 290315004920 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 290315004921 B12 binding site [chemical binding]; other site 290315004922 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 290315004923 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290315004924 FeS/SAM binding site; other site 290315004925 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 290315004926 MutS domain I; Region: MutS_I; pfam01624 290315004927 MutS domain II; Region: MutS_II; pfam05188 290315004928 MutS domain III; Region: MutS_III; pfam05192 290315004929 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 290315004930 Walker A/P-loop; other site 290315004931 ATP binding site [chemical binding]; other site 290315004932 Q-loop/lid; other site 290315004933 ABC transporter signature motif; other site 290315004934 Walker B; other site 290315004935 D-loop; other site 290315004936 H-loop/switch region; other site 290315004937 Copper resistance protein D; Region: CopD; cl00563 290315004938 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 290315004939 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 290315004940 malate dehydrogenase; Reviewed; Region: PRK06223 290315004941 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 290315004942 NAD(P) binding site [chemical binding]; other site 290315004943 dimer interface [polypeptide binding]; other site 290315004944 tetramer (dimer of dimers) interface [polypeptide binding]; other site 290315004945 substrate binding site [chemical binding]; other site 290315004946 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 290315004947 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 290315004948 Peptidase family M48; Region: Peptidase_M48; pfam01435 290315004949 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 290315004950 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 290315004951 putative active site; other site 290315004952 catalytic triad [active] 290315004953 putative dimer interface [polypeptide binding]; other site 290315004954 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 290315004955 UbiA prenyltransferase family; Region: UbiA; pfam01040 290315004956 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 290315004957 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 290315004958 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290315004959 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 290315004960 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 290315004961 substrate binding site [chemical binding]; other site 290315004962 glutamase interaction surface [polypeptide binding]; other site 290315004963 Predicted metalloprotease [General function prediction only]; Region: COG2321 290315004964 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 290315004965 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 290315004966 Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350 290315004967 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 290315004968 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 290315004969 oligomer interface [polypeptide binding]; other site 290315004970 metal binding site [ion binding]; metal-binding site 290315004971 metal binding site [ion binding]; metal-binding site 290315004972 Cl binding site [ion binding]; other site 290315004973 aspartate ring; other site 290315004974 basic sphincter; other site 290315004975 putative hydrophobic gate; other site 290315004976 periplasmic entrance; other site 290315004977 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347 290315004978 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 290315004979 active site 290315004980 catalytic site [active] 290315004981 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 290315004982 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 290315004983 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 290315004984 TPP-binding site; other site 290315004985 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 290315004986 PYR/PP interface [polypeptide binding]; other site 290315004987 dimer interface [polypeptide binding]; other site 290315004988 TPP binding site [chemical binding]; other site 290315004989 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 290315004990 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 290315004991 tetramer interfaces [polypeptide binding]; other site 290315004992 binuclear metal-binding site [ion binding]; other site 290315004993 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 290315004994 MutS domain III; Region: MutS_III; pfam05192 290315004995 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 290315004996 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 290315004997 Walker A/P-loop; other site 290315004998 ATP binding site [chemical binding]; other site 290315004999 Q-loop/lid; other site 290315005000 ABC transporter signature motif; other site 290315005001 Walker B; other site 290315005002 D-loop; other site 290315005003 H-loop/switch region; other site 290315005004 Smr domain; Region: Smr; pfam01713 290315005005 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 290315005006 active site 290315005007 hydrophilic channel; other site 290315005008 dimerization interface [polypeptide binding]; other site 290315005009 catalytic residues [active] 290315005010 active site lid [active] 290315005011 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 290315005012 active site 290315005013 dimerization interface [polypeptide binding]; other site 290315005014 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 290315005015 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 290315005016 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 290315005017 active site 290315005018 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 290315005019 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 290315005020 Permease; Region: Permease; pfam02405 290315005021 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 290315005022 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 290315005023 Walker A/P-loop; other site 290315005024 ATP binding site [chemical binding]; other site 290315005025 Q-loop/lid; other site 290315005026 ABC transporter signature motif; other site 290315005027 Walker B; other site 290315005028 D-loop; other site 290315005029 H-loop/switch region; other site 290315005030 mce related protein; Region: MCE; pfam02470 290315005031 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 290315005032 Beta-lactamase; Region: Beta-lactamase; pfam00144 290315005033 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 290315005034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290315005035 active site 290315005036 phosphorylation site [posttranslational modification] 290315005037 intermolecular recognition site; other site 290315005038 dimerization interface [polypeptide binding]; other site 290315005039 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290315005040 Walker A motif; other site 290315005041 ATP binding site [chemical binding]; other site 290315005042 Walker B motif; other site 290315005043 arginine finger; other site 290315005044 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 290315005045 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 290315005046 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 290315005047 dimerization interface [polypeptide binding]; other site 290315005048 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 290315005049 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290315005050 dimer interface [polypeptide binding]; other site 290315005051 phosphorylation site [posttranslational modification] 290315005052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290315005053 ATP binding site [chemical binding]; other site 290315005054 Mg2+ binding site [ion binding]; other site 290315005055 G-X-G motif; other site 290315005056 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 290315005057 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 290315005058 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290315005059 Soluble P-type ATPase [General function prediction only]; Region: COG4087 290315005060 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 290315005061 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 290315005062 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 290315005063 Ligand Binding Site [chemical binding]; other site 290315005064 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 290315005065 active site 290315005066 phosphorylation site [posttranslational modification] 290315005067 Uncharacterized conserved protein [Function unknown]; Region: COG3349 290315005068 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 290315005069 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 290315005070 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 290315005071 iron-sulfur cluster [ion binding]; other site 290315005072 [2Fe-2S] cluster binding site [ion binding]; other site 290315005073 epoxyqueuosine reductase; Region: TIGR00276 290315005074 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 290315005075 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 290315005076 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 290315005077 purine monophosphate binding site [chemical binding]; other site 290315005078 dimer interface [polypeptide binding]; other site 290315005079 putative catalytic residues [active] 290315005080 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 290315005081 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 290315005082 N-acetyltransferase; Region: Acetyltransf_2; cl00949 290315005083 Protein of unknown function (DUF4019); Region: DUF4019; pfam13211 290315005084 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 290315005085 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 290315005086 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290315005087 motif II; other site 290315005088 DinB superfamily; Region: DinB_2; pfam12867 290315005089 DinB family; Region: DinB; cl17821 290315005090 LysE type translocator; Region: LysE; cl00565 290315005091 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 290315005092 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 290315005093 protein binding site [polypeptide binding]; other site 290315005094 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 290315005095 Helix-turn-helix domain; Region: HTH_28; pfam13518 290315005096 putative transposase OrfB; Reviewed; Region: PHA02517 290315005097 HTH-like domain; Region: HTH_21; pfam13276 290315005098 Integrase core domain; Region: rve; pfam00665 290315005099 Integrase core domain; Region: rve_3; pfam13683 290315005100 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 290315005101 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 290315005102 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 290315005103 AAA domain; Region: AAA_14; pfam13173 290315005104 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 290315005105 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 290315005106 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 290315005107 active site 290315005108 substrate binding site [chemical binding]; other site 290315005109 cosubstrate binding site; other site 290315005110 catalytic site [active] 290315005111 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 290315005112 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290315005113 FeS/SAM binding site; other site 290315005114 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 290315005115 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 290315005116 Ligand binding site; other site 290315005117 Putative Catalytic site; other site 290315005118 DXD motif; other site 290315005119 endonuclease IV; Provisional; Region: PRK01060 290315005120 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 290315005121 AP (apurinic/apyrimidinic) site pocket; other site 290315005122 DNA interaction; other site 290315005123 Metal-binding active site; metal-binding site 290315005124 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 290315005125 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 290315005126 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 290315005127 active site 290315005128 tetramer interface [polypeptide binding]; other site 290315005129 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290315005130 active site 290315005131 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 290315005132 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 290315005133 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290315005134 active site 290315005135 HIGH motif; other site 290315005136 nucleotide binding site [chemical binding]; other site 290315005137 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290315005138 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 290315005139 active site 290315005140 KMSKS motif; other site 290315005141 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 290315005142 tRNA binding surface [nucleotide binding]; other site 290315005143 anticodon binding site; other site 290315005144 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 290315005145 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 290315005146 Substrate binding site; other site 290315005147 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 290315005148 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 290315005149 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290315005150 NAD(P) binding site [chemical binding]; other site 290315005151 active site 290315005152 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 290315005153 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 290315005154 NAD binding site [chemical binding]; other site 290315005155 substrate binding site [chemical binding]; other site 290315005156 homodimer interface [polypeptide binding]; other site 290315005157 active site 290315005158 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 290315005159 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 290315005160 NADP binding site [chemical binding]; other site 290315005161 active site 290315005162 putative substrate binding site [chemical binding]; other site 290315005163 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 290315005164 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 290315005165 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 290315005166 substrate binding site; other site 290315005167 tetramer interface; other site 290315005168 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 290315005169 dimerization interface [polypeptide binding]; other site 290315005170 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 290315005171 ATP binding site [chemical binding]; other site 290315005172 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 290315005173 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 290315005174 HupF/HypC family; Region: HupF_HypC; pfam01455 290315005175 Acylphosphatase; Region: Acylphosphatase; pfam00708 290315005176 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 290315005177 HypF finger; Region: zf-HYPF; pfam07503 290315005178 HypF finger; Region: zf-HYPF; pfam07503 290315005179 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 290315005180 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 290315005181 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 290315005182 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 290315005183 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 290315005184 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 290315005185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 290315005186 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 290315005187 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 290315005188 nudix motif; other site 290315005189 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 290315005190 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 290315005191 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 290315005192 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 290315005193 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 290315005194 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 290315005195 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 290315005196 Na binding site [ion binding]; other site 290315005197 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14671 290315005198 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 290315005199 GIY-YIG motif/motif A; other site 290315005200 active site 290315005201 catalytic site [active] 290315005202 putative DNA binding site [nucleotide binding]; other site 290315005203 metal binding site [ion binding]; metal-binding site 290315005204 UvrB/uvrC motif; Region: UVR; pfam02151 290315005205 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 290315005206 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 290315005207 DNA binding site [nucleotide binding] 290315005208 Tetratricopeptide repeat; Region: TPR_16; pfam13432 290315005209 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290315005210 binding surface 290315005211 TPR repeat; Region: TPR_11; pfam13414 290315005212 TPR motif; other site 290315005213 TPR repeat; Region: TPR_11; pfam13414 290315005214 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290315005215 binding surface 290315005216 TPR motif; other site 290315005217 TPR repeat; Region: TPR_11; pfam13414 290315005218 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290315005219 binding surface 290315005220 Tetratricopeptide repeat; Region: TPR_16; pfam13432 290315005221 TPR motif; other site 290315005222 TPR repeat; Region: TPR_11; pfam13414 290315005223 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290315005224 binding surface 290315005225 TPR motif; other site 290315005226 TPR repeat; Region: TPR_11; pfam13414 290315005227 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 290315005228 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 290315005229 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 290315005230 shikimate binding site; other site 290315005231 NAD(P) binding site [chemical binding]; other site 290315005232 lipoprotein signal peptidase; Provisional; Region: PRK14787 290315005233 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 290315005234 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 290315005235 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 290315005236 active site 290315005237 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 290315005238 active site 290315005239 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 290315005240 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 290315005241 catalytic residue [active] 290315005242 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 290315005243 aminotransferase AlaT; Validated; Region: PRK09265 290315005244 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290315005245 homodimer interface [polypeptide binding]; other site 290315005246 catalytic residue [active] 290315005247 purine nucleoside phosphorylase; Provisional; Region: PRK08202 290315005248 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 290315005249 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 290315005250 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 290315005251 Low-spin heme binding site [chemical binding]; other site 290315005252 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 290315005253 D-pathway; other site 290315005254 Putative water exit pathway; other site 290315005255 Binuclear center (active site) [active] 290315005256 K-pathway; other site 290315005257 Putative proton exit pathway; other site 290315005258 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 290315005259 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 290315005260 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cl00282 290315005261 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 290315005262 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 290315005263 4Fe-4S binding domain; Region: Fer4_5; pfam12801 290315005264 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 290315005265 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 290315005266 FixH; Region: FixH; pfam05751 290315005267 YtkA-like; Region: YtkA; pfam13115 290315005268 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 290315005269 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 290315005270 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 290315005271 metal-binding site [ion binding] 290315005272 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 290315005273 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290315005274 motif II; other site 290315005275 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 290315005276 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 290315005277 Family description; Region: DsbD_2; pfam13386 290315005278 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 290315005279 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 290315005280 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 290315005281 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 290315005282 hypothetical protein; Reviewed; Region: PRK00024 290315005283 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 290315005284 helix-hairpin-helix signature motif; other site 290315005285 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 290315005286 MPN+ (JAMM) motif; other site 290315005287 Zinc-binding site [ion binding]; other site 290315005288 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 290315005289 DNA-binding site [nucleotide binding]; DNA binding site 290315005290 RNA-binding motif; other site 290315005291 classical (c) SDRs; Region: SDR_c; cd05233 290315005292 NAD(P) binding site [chemical binding]; other site 290315005293 active site 290315005294 Yqey-like protein; Region: YqeY; pfam09424 290315005295 seryl-tRNA synthetase; Provisional; Region: PRK05431 290315005296 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 290315005297 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 290315005298 dimer interface [polypeptide binding]; other site 290315005299 active site 290315005300 motif 1; other site 290315005301 motif 2; other site 290315005302 motif 3; other site 290315005303 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 290315005304 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 290315005305 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 290315005306 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 290315005307 homodimer interface [polypeptide binding]; other site 290315005308 substrate-cofactor binding pocket; other site 290315005309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290315005310 catalytic residue [active] 290315005311 16S rRNA methyltransferase B; Provisional; Region: PRK14904 290315005312 NusB family; Region: NusB; pfam01029 290315005313 putative RNA binding site [nucleotide binding]; other site 290315005314 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 290315005315 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 290315005316 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 290315005317 active site 290315005318 Int/Topo IB signature motif; other site 290315005319 TPR repeat; Region: TPR_11; pfam13414 290315005320 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290315005321 binding surface 290315005322 TPR motif; other site 290315005323 TPR repeat; Region: TPR_11; pfam13414 290315005324 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 290315005325 binding surface 290315005326 TPR motif; other site 290315005327 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 290315005328 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 290315005329 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 290315005330 Beta-Casp domain; Region: Beta-Casp; smart01027 290315005331 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 290315005332 Response regulator receiver domain; Region: Response_reg; pfam00072 290315005333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290315005334 active site 290315005335 phosphorylation site [posttranslational modification] 290315005336 intermolecular recognition site; other site 290315005337 dimerization interface [polypeptide binding]; other site 290315005338 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 290315005339 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290315005340 putative active site [active] 290315005341 heme pocket [chemical binding]; other site 290315005342 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290315005343 putative active site [active] 290315005344 heme pocket [chemical binding]; other site 290315005345 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290315005346 dimer interface [polypeptide binding]; other site 290315005347 phosphorylation site [posttranslational modification] 290315005348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290315005349 ATP binding site [chemical binding]; other site 290315005350 Mg2+ binding site [ion binding]; other site 290315005351 G-X-G motif; other site 290315005352 Response regulator receiver domain; Region: Response_reg; pfam00072 290315005353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290315005354 active site 290315005355 phosphorylation site [posttranslational modification] 290315005356 intermolecular recognition site; other site 290315005357 dimerization interface [polypeptide binding]; other site 290315005358 PAS domain S-box; Region: sensory_box; TIGR00229 290315005359 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290315005360 putative active site [active] 290315005361 heme pocket [chemical binding]; other site 290315005362 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 290315005363 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 290315005364 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 290315005365 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290315005366 Walker A motif; other site 290315005367 ATP binding site [chemical binding]; other site 290315005368 Walker B motif; other site 290315005369 arginine finger; other site 290315005370 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 290315005371 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 290315005372 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 290315005373 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 290315005374 Bacterial sugar transferase; Region: Bac_transf; pfam02397 290315005375 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 290315005376 anti sigma factor interaction site; other site 290315005377 regulatory phosphorylation site [posttranslational modification]; other site 290315005378 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290315005379 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 290315005380 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 290315005381 anti sigma factor interaction site; other site 290315005382 regulatory phosphorylation site [posttranslational modification]; other site 290315005383 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 290315005384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 290315005385 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 290315005386 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 290315005387 Probable Catalytic site; other site 290315005388 metal-binding site 290315005389 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 290315005390 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 290315005391 trimer interface [polypeptide binding]; other site 290315005392 active site 290315005393 substrate binding site [chemical binding]; other site 290315005394 CoA binding site [chemical binding]; other site 290315005395 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 290315005396 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 290315005397 SLBB domain; Region: SLBB; pfam10531 290315005398 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 290315005399 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 290315005400 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 290315005401 Chain length determinant protein; Region: Wzz; cl15801 290315005402 AAA domain; Region: AAA_31; pfam13614 290315005403 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 290315005404 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 290315005405 trimer interface [polypeptide binding]; other site 290315005406 active site 290315005407 substrate binding site [chemical binding]; other site 290315005408 CoA binding site [chemical binding]; other site 290315005409 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 290315005410 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290315005411 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 290315005412 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 290315005413 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 290315005414 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 290315005415 active site 290315005416 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 290315005417 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 290315005418 putative ADP-binding pocket [chemical binding]; other site 290315005419 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 290315005420 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 290315005421 DXD motif; other site 290315005422 Acyltransferase family; Region: Acyl_transf_3; pfam01757 290315005423 DEAD-like helicases superfamily; Region: DEXDc; smart00487 290315005424 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 290315005425 ATP binding site [chemical binding]; other site 290315005426 Mg++ binding site [ion binding]; other site 290315005427 motif III; other site 290315005428 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 290315005429 nucleotide binding region [chemical binding]; other site 290315005430 ATP-binding site [chemical binding]; other site 290315005431 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 290315005432 putative RNA binding site [nucleotide binding]; other site 290315005433 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290315005434 Tetratricopeptide repeat; Region: TPR_12; pfam13424 290315005435 TPR motif; other site 290315005436 Tetratricopeptide repeat; Region: TPR_12; pfam13424 290315005437 binding surface 290315005438 Tetratricopeptide repeat; Region: TPR_12; pfam13424 290315005439 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290315005440 binding surface 290315005441 TPR motif; other site 290315005442 Tetratricopeptide repeat; Region: TPR_12; pfam13424 290315005443 Tetratricopeptide repeat; Region: TPR_12; pfam13424 290315005444 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290315005445 binding surface 290315005446 TPR motif; other site 290315005447 Tetratricopeptide repeat; Region: TPR_12; pfam13424 290315005448 Tetratricopeptide repeat; Region: TPR_12; pfam13424 290315005449 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290315005450 binding surface 290315005451 TPR motif; other site 290315005452 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 290315005453 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 290315005454 potassium uptake protein; Region: kup; TIGR00794 290315005455 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 290315005456 Ferritin-like domain; Region: Ferritin; pfam00210 290315005457 ferroxidase diiron center [ion binding]; other site 290315005458 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 290315005459 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 290315005460 putative active site [active] 290315005461 putative metal binding site [ion binding]; other site 290315005462 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 290315005463 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 290315005464 heterodimer interface [polypeptide binding]; other site 290315005465 active site 290315005466 FMN binding site [chemical binding]; other site 290315005467 homodimer interface [polypeptide binding]; other site 290315005468 substrate binding site [chemical binding]; other site 290315005469 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 290315005470 four helix bundle protein; Region: TIGR02436 290315005471 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 290315005472 Clostripain family; Region: Peptidase_C11; pfam03415 290315005473 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 290315005474 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 290315005475 homodimer interface [polypeptide binding]; other site 290315005476 substrate-cofactor binding pocket; other site 290315005477 catalytic residue [active] 290315005478 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 290315005479 DNA polymerase III subunit delta'; Validated; Region: PRK08485 290315005480 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 290315005481 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290315005482 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 290315005483 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 290315005484 putative ADP-binding pocket [chemical binding]; other site 290315005485 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290315005486 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 290315005487 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 290315005488 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290315005489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290315005490 NAD(P) binding site [chemical binding]; other site 290315005491 active site 290315005492 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 290315005493 Putative cyclase; Region: Cyclase; cl00814 290315005494 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 290315005495 ligand binding site; other site 290315005496 tetramer interface; other site 290315005497 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 290315005498 Right handed beta helix region; Region: Beta_helix; pfam13229 290315005499 Domain of unknown function (DUF386); Region: DUF386; cl01047 290315005500 Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like1; cd08196 290315005501 putative active site [active] 290315005502 metal binding site [ion binding]; metal-binding site 290315005503 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 290315005504 classical (c) SDRs; Region: SDR_c; cd05233 290315005505 NAD(P) binding site [chemical binding]; other site 290315005506 active site 290315005507 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290315005508 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290315005509 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290315005510 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 290315005511 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 290315005512 NAD binding site [chemical binding]; other site 290315005513 Homeodomain-like domain; Region: HTH_32; pfam13565 290315005514 Integrase core domain; Region: rve; pfam00665 290315005515 Integrase core domain; Region: rve_3; pfam13683 290315005516 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 290315005517 dimer interface [polypeptide binding]; other site 290315005518 active site 290315005519 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 290315005520 Helix-turn-helix domain; Region: HTH_28; pfam13518 290315005521 putative transposase OrfB; Reviewed; Region: PHA02517 290315005522 HTH-like domain; Region: HTH_21; pfam13276 290315005523 Integrase core domain; Region: rve; pfam00665 290315005524 Integrase core domain; Region: rve_3; pfam13683 290315005525 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 290315005526 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 290315005527 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 290315005528 putative ligand binding site [chemical binding]; other site 290315005529 putative NAD binding site [chemical binding]; other site 290315005530 catalytic site [active] 290315005531 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 290315005532 putative transposase OrfB; Reviewed; Region: PHA02517 290315005533 HTH-like domain; Region: HTH_21; pfam13276 290315005534 Integrase core domain; Region: rve; pfam00665 290315005535 Integrase core domain; Region: rve_3; pfam13683 290315005536 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 290315005537 Helix-turn-helix domain; Region: HTH_28; pfam13518 290315005538 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 290315005539 four helix bundle protein; Region: TIGR02436 290315005540 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 290315005541 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 290315005542 Mg++ binding site [ion binding]; other site 290315005543 putative catalytic motif [active] 290315005544 substrate binding site [chemical binding]; other site 290315005545 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 290315005546 Chain length determinant protein; Region: Wzz; cl15801 290315005547 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 290315005548 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 290315005549 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 290315005550 Nucleotide binding site [chemical binding]; other site 290315005551 DTAP/Switch II; other site 290315005552 Switch I; other site 290315005553 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 290315005554 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 290315005555 Catalytic site [active] 290315005556 SynChlorMet cassette protein ScmC; Region: SCM_chp_ScmC; TIGR04249 290315005557 SynChlorMet cassette protein ScmD; Region: SCM_PqqD_rel; TIGR04248 290315005558 SynChlorMet cassette protein ScmA; Region: SCM_precur_ScmA; TIGR04252 290315005559 SynChlorMet cassette radical SAM/SPASM protein ScmF; Region: SCM_rSAM_ScmF; TIGR04251 290315005560 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290315005561 FeS/SAM binding site; other site 290315005562 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 290315005563 SynChlorMet cassette radical SAM/SPASM protein ScmE; Region: SCM_rSAM_ScmE; TIGR04250 290315005564 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290315005565 FeS/SAM binding site; other site 290315005566 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 290315005567 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 290315005568 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290315005569 Walker A/P-loop; other site 290315005570 ATP binding site [chemical binding]; other site 290315005571 Q-loop/lid; other site 290315005572 ABC transporter signature motif; other site 290315005573 Walker B; other site 290315005574 D-loop; other site 290315005575 H-loop/switch region; other site 290315005576 Peptidase S8 family domain, uncharacterized subfamily 12; Region: Peptidases_S8_12; cd07480 290315005577 active site 290315005578 catalytic triad [active] 290315005579 CHAT domain; Region: CHAT; cl17868 290315005580 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 290315005581 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 290315005582 active site 290315005583 intersubunit interface [polypeptide binding]; other site 290315005584 catalytic residue [active] 290315005585 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 290315005586 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 290315005587 dimer interface [polypeptide binding]; other site 290315005588 active site 290315005589 metal binding site [ion binding]; metal-binding site 290315005590 Transposase IS200 like; Region: Y1_Tnp; cl00848 290315005591 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 290315005592 active site 290315005593 metal binding site [ion binding]; metal-binding site 290315005594 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 290315005595 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 290315005596 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 290315005597 active site 290315005598 metal binding site [ion binding]; metal-binding site 290315005599 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 290315005600 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 290315005601 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 290315005602 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290315005603 Walker A motif; other site 290315005604 ATP binding site [chemical binding]; other site 290315005605 Walker B motif; other site 290315005606 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 290315005607 Domain of unknown function (DUF4404); Region: DUF4404; pfam14357 290315005608 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 290315005609 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 290315005610 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 290315005611 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 290315005612 active site 290315005613 dimer interface [polypeptide binding]; other site 290315005614 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 290315005615 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 290315005616 active site 290315005617 FMN binding site [chemical binding]; other site 290315005618 substrate binding site [chemical binding]; other site 290315005619 3Fe-4S cluster binding site [ion binding]; other site 290315005620 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 290315005621 domain interface; other site 290315005622 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290315005623 catalytic core [active] 290315005624 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290315005625 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 290315005626 FMN binding site [chemical binding]; other site 290315005627 substrate binding site [chemical binding]; other site 290315005628 putative catalytic residue [active] 290315005629 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 290315005630 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 290315005631 nucleoside/Zn binding site; other site 290315005632 dimer interface [polypeptide binding]; other site 290315005633 catalytic motif [active] 290315005634 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 290315005635 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 290315005636 CoA-ligase; Region: Ligase_CoA; pfam00549 290315005637 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 290315005638 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 290315005639 Walker A/P-loop; other site 290315005640 ATP binding site [chemical binding]; other site 290315005641 Q-loop/lid; other site 290315005642 ABC transporter signature motif; other site 290315005643 Walker B; other site 290315005644 D-loop; other site 290315005645 H-loop/switch region; other site 290315005646 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 290315005647 FtsX-like permease family; Region: FtsX; pfam02687 290315005648 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 290315005649 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 290315005650 carboxyltransferase (CT) interaction site; other site 290315005651 biotinylation site [posttranslational modification]; other site 290315005652 HlyD family secretion protein; Region: HlyD_3; pfam13437 290315005653 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 290315005654 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 290315005655 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290315005656 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290315005657 ABC transporter; Region: ABC_tran_2; pfam12848 290315005658 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 290315005659 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 290315005660 PAS fold; Region: PAS_3; pfam08447 290315005661 putative active site [active] 290315005662 heme pocket [chemical binding]; other site 290315005663 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 290315005664 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 290315005665 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290315005666 dimer interface [polypeptide binding]; other site 290315005667 phosphorylation site [posttranslational modification] 290315005668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290315005669 ATP binding site [chemical binding]; other site 290315005670 Mg2+ binding site [ion binding]; other site 290315005671 G-X-G motif; other site 290315005672 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 290315005673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290315005674 active site 290315005675 phosphorylation site [posttranslational modification] 290315005676 intermolecular recognition site; other site 290315005677 dimerization interface [polypeptide binding]; other site 290315005678 Response regulator receiver domain; Region: Response_reg; pfam00072 290315005679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290315005680 active site 290315005681 phosphorylation site [posttranslational modification] 290315005682 intermolecular recognition site; other site 290315005683 dimerization interface [polypeptide binding]; other site 290315005684 multidrug efflux system protein; Provisional; Region: PRK11431 290315005685 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 290315005686 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 290315005687 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 290315005688 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 290315005689 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290315005690 FeS/SAM binding site; other site 290315005691 HemN C-terminal domain; Region: HemN_C; pfam06969 290315005692 AIR carboxylase; Region: AIRC; pfam00731 290315005693 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 290315005694 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 290315005695 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290315005696 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290315005697 acetylornithine aminotransferase; Provisional; Region: PRK02627 290315005698 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290315005699 inhibitor-cofactor binding pocket; inhibition site 290315005700 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290315005701 catalytic residue [active] 290315005702 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 290315005703 Methyltransferase domain; Region: Methyltransf_23; pfam13489 290315005704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290315005705 S-adenosylmethionine binding site [chemical binding]; other site 290315005706 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 290315005707 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 290315005708 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 290315005709 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 290315005710 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 290315005711 DNA primase; Validated; Region: dnaG; PRK05667 290315005712 CHC2 zinc finger; Region: zf-CHC2; pfam01807 290315005713 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 290315005714 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 290315005715 active site 290315005716 metal binding site [ion binding]; metal-binding site 290315005717 interdomain interaction site; other site 290315005718 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 290315005719 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 290315005720 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 290315005721 dimer interface [polypeptide binding]; other site 290315005722 active site 290315005723 glycine-pyridoxal phosphate binding site [chemical binding]; other site 290315005724 folate binding site [chemical binding]; other site 290315005725 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 290315005726 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 290315005727 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 290315005728 dimerization interface [polypeptide binding]; other site 290315005729 active site 290315005730 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 290315005731 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 290315005732 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 290315005733 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 290315005734 ATP-grasp domain; Region: ATP-grasp_4; cl17255 290315005735 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 290315005736 IMP binding site; other site 290315005737 dimer interface [polypeptide binding]; other site 290315005738 interdomain contacts; other site 290315005739 partial ornithine binding site; other site 290315005740 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 290315005741 classical (c) SDRs; Region: SDR_c; cd05233 290315005742 NAD(P) binding site [chemical binding]; other site 290315005743 active site 290315005744 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 290315005745 ribulose bisphosphate carboxylase, type III; Region: rubisco_III; TIGR03326 290315005746 dimer interface [polypeptide binding]; other site 290315005747 catalytic residue [active] 290315005748 metal binding site [ion binding]; metal-binding site 290315005749 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 290315005750 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 290315005751 putative active site; other site 290315005752 catalytic residue [active] 290315005753 short chain dehydrogenase; Validated; Region: PRK08324 290315005754 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 290315005755 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 290315005756 putative NAD(P) binding site [chemical binding]; other site 290315005757 active site 290315005758 2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284 290315005759 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 290315005760 B12 binding site [chemical binding]; other site 290315005761 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 290315005762 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290315005763 FeS/SAM binding site; other site 290315005764 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 290315005765 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 290315005766 hybrid cluster protein; Provisional; Region: PRK05290 290315005767 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 290315005768 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 290315005769 hybrid metal cluster; other site 290315005770 TPR repeat; Region: TPR_11; pfam13414 290315005771 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290315005772 binding surface 290315005773 TPR motif; other site 290315005774 4Fe-4S binding domain; Region: Fer4_6; pfam12837 290315005775 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 290315005776 Rrf2 family protein; Region: rrf2_super; TIGR00738 290315005777 Transcriptional regulator; Region: Rrf2; pfam02082 290315005778 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290315005779 Haem-binding domain; Region: Haem_bd; pfam14376 290315005780 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 290315005781 Peptidase family M50; Region: Peptidase_M50; pfam02163 290315005782 active site 290315005783 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 290315005784 putative substrate binding region [chemical binding]; other site 290315005785 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 290315005786 dihydropteroate synthase; Region: DHPS; TIGR01496 290315005787 substrate binding pocket [chemical binding]; other site 290315005788 dimer interface [polypeptide binding]; other site 290315005789 inhibitor binding site; inhibition site 290315005790 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 290315005791 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 290315005792 Walker A/P-loop; other site 290315005793 ATP binding site [chemical binding]; other site 290315005794 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 290315005795 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 290315005796 ABC transporter signature motif; other site 290315005797 Walker B; other site 290315005798 D-loop; other site 290315005799 H-loop/switch region; other site 290315005800 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 290315005801 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290315005802 motif II; other site 290315005803 transcription antitermination factor NusB; Region: nusB; TIGR01951 290315005804 putative RNA binding site [nucleotide binding]; other site 290315005805 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 290315005806 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 290315005807 active site 290315005808 metal binding site [ion binding]; metal-binding site 290315005809 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 290315005810 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 290315005811 helix-hairpin-helix signature motif; other site 290315005812 substrate binding pocket [chemical binding]; other site 290315005813 active site 290315005814 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 290315005815 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 290315005816 aminodeoxychorismate synthase; Provisional; Region: PRK07508 290315005817 chorismate binding enzyme; Region: Chorismate_bind; cl10555 290315005818 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 290315005819 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 290315005820 substrate-cofactor binding pocket; other site 290315005821 homodimer interface [polypeptide binding]; other site 290315005822 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290315005823 catalytic residue [active] 290315005824 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 290315005825 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 290315005826 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 290315005827 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 290315005828 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 290315005829 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 290315005830 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 290315005831 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290315005832 RNA binding surface [nucleotide binding]; other site 290315005833 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 290315005834 active site 290315005835 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 290315005836 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 290315005837 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 290315005838 catalytic residues [active] 290315005839 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 290315005840 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 290315005841 putative active site [active] 290315005842 oxyanion strand; other site 290315005843 catalytic triad [active] 290315005844 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 290315005845 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 290315005846 FAD binding pocket [chemical binding]; other site 290315005847 FAD binding motif [chemical binding]; other site 290315005848 phosphate binding motif [ion binding]; other site 290315005849 beta-alpha-beta structure motif; other site 290315005850 NAD binding pocket [chemical binding]; other site 290315005851 Iron coordination center [ion binding]; other site 290315005852 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 290315005853 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 290315005854 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290315005855 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 290315005856 nickel responsive regulator; Provisional; Region: PRK04460 290315005857 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 290315005858 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 290315005859 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 290315005860 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 290315005861 PDGLE domain; Region: PDGLE; pfam13190 290315005862 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 290315005863 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 290315005864 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 290315005865 Walker A/P-loop; other site 290315005866 ATP binding site [chemical binding]; other site 290315005867 Q-loop/lid; other site 290315005868 ABC transporter signature motif; other site 290315005869 Walker B; other site 290315005870 D-loop; other site 290315005871 H-loop/switch region; other site 290315005872 Uncharacterized conserved protein [Function unknown]; Region: COG1432 290315005873 LabA_like proteins; Region: LabA; cd10911 290315005874 putative metal binding site [ion binding]; other site 290315005875 Predicted permeases [General function prediction only]; Region: COG0679 290315005876 Ferrochelatase; Region: Ferrochelatase; pfam00762 290315005877 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 290315005878 C-terminal domain interface [polypeptide binding]; other site 290315005879 active site 290315005880 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 290315005881 active site 290315005882 N-terminal domain interface [polypeptide binding]; other site 290315005883 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 290315005884 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 290315005885 HlyD family secretion protein; Region: HlyD_3; pfam13437 290315005886 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 290315005887 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 290315005888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290315005889 S-adenosylmethionine binding site [chemical binding]; other site 290315005890 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 290315005891 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 290315005892 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 290315005893 nucleotide binding pocket [chemical binding]; other site 290315005894 K-X-D-G motif; other site 290315005895 catalytic site [active] 290315005896 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 290315005897 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 290315005898 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 290315005899 Dimer interface [polypeptide binding]; other site 290315005900 BRCT sequence motif; other site 290315005901 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 290315005902 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 290315005903 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 290315005904 Walker A/P-loop; other site 290315005905 ATP binding site [chemical binding]; other site 290315005906 Q-loop/lid; other site 290315005907 ABC transporter signature motif; other site 290315005908 Walker B; other site 290315005909 D-loop; other site 290315005910 H-loop/switch region; other site 290315005911 Flagellin N-methylase; Region: FliB; pfam03692 290315005912 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 290315005913 arsenical-resistance protein; Region: acr3; TIGR00832 290315005914 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 290315005915 Low molecular weight phosphatase family; Region: LMWPc; cd00115 290315005916 active site 290315005917 Predicted permeases [General function prediction only]; Region: COG0701 290315005918 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 290315005919 active site residue [active] 290315005920 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 290315005921 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290315005922 dimerization interface [polypeptide binding]; other site 290315005923 putative DNA binding site [nucleotide binding]; other site 290315005924 putative Zn2+ binding site [ion binding]; other site 290315005925 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 290315005926 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 290315005927 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 290315005928 non-specific DNA binding site [nucleotide binding]; other site 290315005929 salt bridge; other site 290315005930 sequence-specific DNA binding site [nucleotide binding]; other site 290315005931 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 290315005932 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 290315005933 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 290315005934 catalytic residues [active] 290315005935 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 290315005936 chlorophyllide reductase subunit Y; Region: BchY; TIGR02015 290315005937 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 290315005938 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 290315005939 generic binding surface II; other site 290315005940 generic binding surface I; other site 290315005941 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 290315005942 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 290315005943 Ligand binding site; other site 290315005944 oligomer interface; other site 290315005945 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 290315005946 putative active site [active] 290315005947 dimerization interface [polypeptide binding]; other site 290315005948 putative tRNAtyr binding site [nucleotide binding]; other site 290315005949 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 290315005950 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 290315005951 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 290315005952 Citrate synthase; Region: Citrate_synt; pfam00285 290315005953 oxalacetate binding site [chemical binding]; other site 290315005954 citrylCoA binding site [chemical binding]; other site 290315005955 coenzyme A binding site [chemical binding]; other site 290315005956 catalytic triad [active] 290315005957 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 290315005958 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 290315005959 ligand binding site [chemical binding]; other site 290315005960 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 290315005961 putative metal binding site [ion binding]; other site 290315005962 Uncharacterized conserved protein [Function unknown]; Region: COG1432 290315005963 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 290315005964 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 290315005965 metal-binding site [ion binding] 290315005966 TPR repeat; Region: TPR_11; pfam13414 290315005967 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290315005968 binding surface 290315005969 TPR motif; other site 290315005970 TPR repeat; Region: TPR_11; pfam13414 290315005971 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290315005972 binding surface 290315005973 TPR motif; other site 290315005974 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 290315005975 chorismate binding enzyme; Region: Chorismate_bind; cl10555 290315005976 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 290315005977 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 290315005978 dimer interface [polypeptide binding]; other site 290315005979 tetramer interface [polypeptide binding]; other site 290315005980 PYR/PP interface [polypeptide binding]; other site 290315005981 TPP binding site [chemical binding]; other site 290315005982 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 290315005983 TPP-binding site; other site 290315005984 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 290315005985 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 290315005986 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 290315005987 substrate binding site [chemical binding]; other site 290315005988 oxyanion hole (OAH) forming residues; other site 290315005989 trimer interface [polypeptide binding]; other site 290315005990 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 290315005991 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 290315005992 active site 290315005993 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 290315005994 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 290315005995 acyl-activating enzyme (AAE) consensus motif; other site 290315005996 putative AMP binding site [chemical binding]; other site 290315005997 putative active site [active] 290315005998 putative CoA binding site [chemical binding]; other site 290315005999 dihydrodipicolinate reductase; Provisional; Region: PRK00048 290315006000 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 290315006001 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 290315006002 ParB-like nuclease domain; Region: ParB; smart00470 290315006003 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 290315006004 KorB domain; Region: KorB; pfam08535 290315006005 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 290315006006 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290315006007 P-loop; other site 290315006008 Magnesium ion binding site [ion binding]; other site 290315006009 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 290315006010 Magnesium ion binding site [ion binding]; other site 290315006011 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 290315006012 active site 290315006013 DNA binding site [nucleotide binding] 290315006014 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 290315006015 MgtE intracellular N domain; Region: MgtE_N; pfam03448 290315006016 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 290315006017 Divalent cation transporter; Region: MgtE; pfam01769 290315006018 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 290315006019 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 290315006020 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 290315006021 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 290315006022 Ligand Binding Site [chemical binding]; other site 290315006023 Predicted esterase [General function prediction only]; Region: COG0400 290315006024 putative hydrolase; Provisional; Region: PRK11460 290315006025 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 290315006026 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 290315006027 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 290315006028 substrate binding pocket [chemical binding]; other site 290315006029 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 290315006030 B12 binding site [chemical binding]; other site 290315006031 cobalt ligand [ion binding]; other site 290315006032 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 290315006033 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 290315006034 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 290315006035 catalytic triad [active] 290315006036 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 290315006037 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 290315006038 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 290315006039 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 290315006040 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 290315006041 Putative molybdenum carrier; Region: MoCo_carrier; pfam12694 290315006042 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 290315006043 putative hydrophobic ligand binding site [chemical binding]; other site 290315006044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 290315006045 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 290315006046 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 290315006047 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 290315006048 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 290315006049 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 290315006050 Uncharacterized protein family (UPF0259); Region: UPF0259; cl11642 290315006051 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 290315006052 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 290315006053 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 290315006054 putative active site [active] 290315006055 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 290315006056 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 290315006057 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 290315006058 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 290315006059 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 290315006060 PAS domain S-box; Region: sensory_box; TIGR00229 290315006061 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 290315006062 dimer interface [polypeptide binding]; other site 290315006063 phosphorylation site [posttranslational modification] 290315006064 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290315006065 ATP binding site [chemical binding]; other site 290315006066 Mg2+ binding site [ion binding]; other site 290315006067 G-X-G motif; other site 290315006068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290315006069 active site 290315006070 phosphorylation site [posttranslational modification] 290315006071 intermolecular recognition site; other site 290315006072 dimerization interface [polypeptide binding]; other site 290315006073 Response regulator receiver domain; Region: Response_reg; pfam00072 290315006074 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 290315006075 active site 290315006076 phosphorylation site [posttranslational modification] 290315006077 intermolecular recognition site; other site 290315006078 dimerization interface [polypeptide binding]; other site 290315006079 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 290315006080 putative binding surface; other site 290315006081 active site 290315006082 Uncharacterized conserved protein [Function unknown]; Region: COG3287 290315006083 FIST N domain; Region: FIST; pfam08495 290315006084 FIST C domain; Region: FIST_C; pfam10442 290315006085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 290315006086 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290315006087 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 290315006088 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 290315006089 putative deacylase active site [active] 290315006090 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 290315006091 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 290315006092 nucleophile elbow; other site 290315006093 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 290315006094 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 290315006095 NAD(P) binding site [chemical binding]; other site 290315006096 catalytic residues [active] 290315006097 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 290315006098 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290315006099 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 290315006100 Walker A/P-loop; other site 290315006101 ATP binding site [chemical binding]; other site 290315006102 Q-loop/lid; other site 290315006103 ABC transporter signature motif; other site 290315006104 Walker B; other site 290315006105 D-loop; other site 290315006106 H-loop/switch region; other site 290315006107 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 290315006108 AAA domain; Region: AAA_32; pfam13654 290315006109 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 290315006110 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290315006111 Ligand Binding Site [chemical binding]; other site 290315006112 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 290315006113 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 290315006114 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 290315006115 Peptidase family U32; Region: Peptidase_U32; pfam01136 290315006116 sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910 290315006117 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 290315006118 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 290315006119 FAD binding pocket [chemical binding]; other site 290315006120 FAD binding motif [chemical binding]; other site 290315006121 phosphate binding motif [ion binding]; other site 290315006122 beta-alpha-beta structure motif; other site 290315006123 NAD binding pocket [chemical binding]; other site 290315006124 Iron coordination center [ion binding]; other site 290315006125 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 290315006126 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 290315006127 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 290315006128 four helix bundle suffix domain; Region: 4helix_suffix; TIGR04258 290315006129 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 290315006130 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 290315006131 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 290315006132 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 290315006133 Coenzyme A binding pocket [chemical binding]; other site 290315006134 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 290315006135 Helix-turn-helix domain; Region: HTH_28; pfam13518 290315006136 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 290315006137 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 290315006138 Part of AAA domain; Region: AAA_19; pfam13245 290315006139 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 290315006140 AAA domain; Region: AAA_12; pfam13087 290315006141 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 290315006142 putative active site [active] 290315006143 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 290315006144 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 290315006145 putative addiction module antidote; Region: doc_partner; TIGR02609 290315006146 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 290315006147 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 290315006148 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 290315006149 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 290315006150 Mechanosensitive ion channel; Region: MS_channel; pfam00924 290315006151 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 290315006152 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 290315006153 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 290315006154 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 290315006155 trimer interface [polypeptide binding]; other site 290315006156 putative metal binding site [ion binding]; other site 290315006157 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 290315006158 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 290315006159 Walker A/P-loop; other site 290315006160 ATP binding site [chemical binding]; other site 290315006161 Q-loop/lid; other site 290315006162 ABC transporter signature motif; other site 290315006163 Walker B; other site 290315006164 D-loop; other site 290315006165 H-loop/switch region; other site 290315006166 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 290315006167 B12 binding domain; Region: B12-binding; pfam02310 290315006168 B12 binding site [chemical binding]; other site 290315006169 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290315006170 FeS/SAM binding site; other site 290315006171 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 290315006172 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 290315006173 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 290315006174 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 290315006175 Zn2+ binding site [ion binding]; other site 290315006176 Mg2+ binding site [ion binding]; other site 290315006177 YtxH-like protein; Region: YtxH; pfam12732 290315006178 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 290315006179 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 290315006180 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 290315006181 hinge; other site 290315006182 active site 290315006183 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 290315006184 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 290315006185 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 290315006186 dimer interface [polypeptide binding]; other site 290315006187 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290315006188 catalytic residue [active] 290315006189 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 290315006190 alanine racemase; Reviewed; Region: alr; PRK00053 290315006191 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 290315006192 active site 290315006193 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 290315006194 dimer interface [polypeptide binding]; other site 290315006195 substrate binding site [chemical binding]; other site 290315006196 catalytic residues [active] 290315006197 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 290315006198 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 290315006199 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 290315006200 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 290315006201 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 290315006202 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 290315006203 FMN binding site [chemical binding]; other site 290315006204 active site 290315006205 catalytic residues [active] 290315006206 substrate binding site [chemical binding]; other site 290315006207 recombinase A; Provisional; Region: recA; PRK09354 290315006208 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 290315006209 hexamer interface [polypeptide binding]; other site 290315006210 Walker A motif; other site 290315006211 ATP binding site [chemical binding]; other site 290315006212 Walker B motif; other site 290315006213 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 290315006214 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 290315006215 putative NADP binding site [chemical binding]; other site 290315006216 putative substrate binding site [chemical binding]; other site 290315006217 active site 290315006218 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 290315006219 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 290315006220 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 290315006221 trigger factor; Region: tig; TIGR00115 290315006222 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 290315006223 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 290315006224 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 290315006225 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 290315006226 dimerization interface [polypeptide binding]; other site 290315006227 active site 290315006228 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 290315006229 active site 290315006230 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 290315006231 catalytic center binding site [active] 290315006232 ATP binding site [chemical binding]; other site 290315006233 Transposase [DNA replication, recombination, and repair]; Region: COG5421 290315006234 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 290315006235 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 290315006236 P loop; other site 290315006237 Nucleotide binding site [chemical binding]; other site 290315006238 DTAP/Switch II; other site 290315006239 Switch I; other site 290315006240 Bacteriochlorophyll C binding protein; Region: Bac_chlorC; pfam02043 290315006241 Chlorosome envelope protein C; Region: Chlorosome_CsmC; pfam11098 290315006242 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 290315006243 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 290315006244 P loop; other site 290315006245 Nucleotide binding site [chemical binding]; other site 290315006246 DTAP/Switch II; other site 290315006247 Switch I; other site 290315006248 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 290315006249 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 290315006250 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 290315006251 FAD binding pocket [chemical binding]; other site 290315006252 FAD binding motif [chemical binding]; other site 290315006253 phosphate binding motif [ion binding]; other site 290315006254 beta-alpha-beta structure motif; other site 290315006255 NAD binding pocket [chemical binding]; other site 290315006256 Iron coordination center [ion binding]; other site 290315006257 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 290315006258 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 290315006259 dimer interface [polypeptide binding]; other site 290315006260 ssDNA binding site [nucleotide binding]; other site 290315006261 tetramer (dimer of dimers) interface [polypeptide binding]; other site 290315006262 DNA polymerase III, delta subunit; Region: holA; TIGR01128 290315006263 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 290315006264 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290315006265 NAD(P) binding site [chemical binding]; other site 290315006266 active site 290315006267 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 290315006268 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 290315006269 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290315006270 catalytic residue [active] 290315006271 Cna protein B-type domain; Region: Cna_B_2; pfam13715 290315006272 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 290315006273 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 290315006274 N-terminal plug; other site 290315006275 ligand-binding site [chemical binding]; other site 290315006276 magnesium chelatase, H subunit; Region: BchH; TIGR02025 290315006277 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 290315006278 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 290315006279 magnesium chelatase subunit H; Provisional; Region: PRK12493 290315006280 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 290315006281 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 290315006282 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 290315006283 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 290315006284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290315006285 S-adenosylmethionine binding site [chemical binding]; other site 290315006286 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 290315006287 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 290315006288 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 290315006289 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290315006290 FeS/SAM binding site; other site 290315006291 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 290315006292 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 290315006293 putative dimer interface [polypeptide binding]; other site 290315006294 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 290315006295 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 290315006296 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 290315006297 putative peptidase; Provisional; Region: PRK11649 290315006298 Peptidase family M23; Region: Peptidase_M23; pfam01551 290315006299 hypothetical protein; Provisional; Region: PRK09256 290315006300 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 290315006301 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 290315006302 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 290315006303 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 290315006304 FOG: WD40 repeat [General function prediction only]; Region: COG2319 290315006305 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 290315006306 structural tetrad; other site 290315006307 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 290315006308 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 290315006309 DXD motif; other site 290315006310 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 290315006311 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 290315006312 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 290315006313 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 290315006314 putative active site [active] 290315006315 putative metal binding site [ion binding]; other site 290315006316 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 290315006317 bacteriochlorophyll c synthase; Provisional; Region: PRK12392 290315006318 UbiA prenyltransferase family; Region: UbiA; pfam01040 290315006319 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14340 290315006320 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 290315006321 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290315006322 FeS/SAM binding site; other site 290315006323 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 290315006324 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 290315006325 trimerization site [polypeptide binding]; other site 290315006326 active site 290315006327 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 290315006328 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 290315006329 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 290315006330 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290315006331 catalytic residue [active] 290315006332 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 290315006333 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 290315006334 dimer interface [polypeptide binding]; other site 290315006335 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290315006336 catalytic residue [active] 290315006337 short chain dehydrogenase; Provisional; Region: PRK12828 290315006338 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 290315006339 NAD(P) binding site [chemical binding]; other site 290315006340 active site 290315006341 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 290315006342 Helix-turn-helix domain; Region: HTH_25; pfam13413 290315006343 non-specific DNA binding site [nucleotide binding]; other site 290315006344 salt bridge; other site 290315006345 sequence-specific DNA binding site [nucleotide binding]; other site 290315006346 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 290315006347 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 290315006348 active site 290315006349 multimer interface [polypeptide binding]; other site 290315006350 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 290315006351 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 290315006352 RNA methyltransferase, RsmE family; Region: TIGR00046 290315006353 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 290315006354 UAF complex subunit Rrn10; Region: UAF_Rrn10; pfam05234 290315006355 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 290315006356 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 290315006357 nucleotide binding site [chemical binding]; other site 290315006358 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 290315006359 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 290315006360 active site 290315006361 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 290315006362 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 290315006363 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290315006364 FeS/SAM binding site; other site 290315006365 HemN C-terminal domain; Region: HemN_C; pfam06969 290315006366 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 290315006367 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290315006368 active site 290315006369 motif I; other site 290315006370 motif II; other site 290315006371 glycogen synthase; Provisional; Region: PRK14098 290315006372 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 290315006373 ADP-binding pocket [chemical binding]; other site 290315006374 homodimer interface [polypeptide binding]; other site 290315006375 Bacterial Ig-like domain; Region: Big_5; pfam13205 290315006376 V4R domain; Region: V4R; cl15268 290315006377 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 290315006378 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 290315006379 P-loop; other site 290315006380 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 290315006381 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 290315006382 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 290315006383 light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842 290315006384 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 290315006385 Domain of unknown function DUF77; Region: DUF77; pfam01910 290315006386 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 290315006387 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 290315006388 GDP-binding site [chemical binding]; other site 290315006389 ACT binding site; other site 290315006390 IMP binding site; other site 290315006391 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 290315006392 Dynamin family; Region: Dynamin_N; pfam00350 290315006393 G1 box; other site 290315006394 GTP/Mg2+ binding site [chemical binding]; other site 290315006395 Switch I region; other site 290315006396 G2 box; other site 290315006397 G3 box; other site 290315006398 Switch II region; other site 290315006399 G4 box; other site 290315006400 G5 box; other site 290315006401 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 290315006402 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 290315006403 active site 290315006404 HIGH motif; other site 290315006405 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 290315006406 KMSKS motif; other site 290315006407 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 290315006408 tRNA binding surface [nucleotide binding]; other site 290315006409 anticodon binding site; other site 290315006410 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 290315006411 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 290315006412 Substrate binding site; other site 290315006413 Cupin domain; Region: Cupin_2; cl17218 290315006414 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 290315006415 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 290315006416 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 290315006417 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 290315006418 alphaNTD homodimer interface [polypeptide binding]; other site 290315006419 alphaNTD - beta interaction site [polypeptide binding]; other site 290315006420 alphaNTD - beta' interaction site [polypeptide binding]; other site 290315006421 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 290315006422 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 290315006423 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 290315006424 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 290315006425 RNA binding surface [nucleotide binding]; other site 290315006426 30S ribosomal protein S11; Validated; Region: PRK05309 290315006427 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 290315006428 30S ribosomal protein S13; Region: bact_S13; TIGR03631 290315006429 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 290315006430 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 290315006431 rRNA binding site [nucleotide binding]; other site 290315006432 predicted 30S ribosome binding site; other site 290315006433 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 290315006434 active site 290315006435 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 290315006436 SecY translocase; Region: SecY; pfam00344 290315006437 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 290315006438 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 290315006439 23S rRNA binding site [nucleotide binding]; other site 290315006440 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 290315006441 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 290315006442 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 290315006443 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 290315006444 5S rRNA interface [nucleotide binding]; other site 290315006445 L27 interface [polypeptide binding]; other site 290315006446 23S rRNA interface [nucleotide binding]; other site 290315006447 L5 interface [polypeptide binding]; other site 290315006448 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 290315006449 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 290315006450 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 290315006451 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 290315006452 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 290315006453 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 290315006454 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 290315006455 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 290315006456 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 290315006457 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 290315006458 RNA binding site [nucleotide binding]; other site 290315006459 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 290315006460 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 290315006461 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 290315006462 putative translocon interaction site; other site 290315006463 23S rRNA interface [nucleotide binding]; other site 290315006464 signal recognition particle (SRP54) interaction site; other site 290315006465 L23 interface [polypeptide binding]; other site 290315006466 trigger factor interaction site; other site 290315006467 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 290315006468 23S rRNA interface [nucleotide binding]; other site 290315006469 5S rRNA interface [nucleotide binding]; other site 290315006470 putative antibiotic binding site [chemical binding]; other site 290315006471 L25 interface [polypeptide binding]; other site 290315006472 L27 interface [polypeptide binding]; other site 290315006473 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 290315006474 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 290315006475 G-X-X-G motif; other site 290315006476 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 290315006477 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 290315006478 putative translocon binding site; other site 290315006479 protein-rRNA interface [nucleotide binding]; other site 290315006480 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 290315006481 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 290315006482 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 290315006483 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 290315006484 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 290315006485 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 290315006486 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 290315006487 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 290315006488 elongation factor Tu; Reviewed; Region: PRK00049 290315006489 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 290315006490 G1 box; other site 290315006491 GEF interaction site [polypeptide binding]; other site 290315006492 GTP/Mg2+ binding site [chemical binding]; other site 290315006493 Switch I region; other site 290315006494 G2 box; other site 290315006495 G3 box; other site 290315006496 Switch II region; other site 290315006497 G4 box; other site 290315006498 G5 box; other site 290315006499 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 290315006500 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 290315006501 Antibiotic Binding Site [chemical binding]; other site 290315006502 elongation factor G; Reviewed; Region: PRK00007 290315006503 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 290315006504 G1 box; other site 290315006505 putative GEF interaction site [polypeptide binding]; other site 290315006506 GTP/Mg2+ binding site [chemical binding]; other site 290315006507 Switch I region; other site 290315006508 G2 box; other site 290315006509 G3 box; other site 290315006510 Switch II region; other site 290315006511 G4 box; other site 290315006512 G5 box; other site 290315006513 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 290315006514 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 290315006515 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 290315006516 30S ribosomal protein S7; Validated; Region: PRK05302 290315006517 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 290315006518 S17 interaction site [polypeptide binding]; other site 290315006519 S8 interaction site; other site 290315006520 16S rRNA interaction site [nucleotide binding]; other site 290315006521 streptomycin interaction site [chemical binding]; other site 290315006522 23S rRNA interaction site [nucleotide binding]; other site 290315006523 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 290315006524 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 290315006525 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 290315006526 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 290315006527 NADH(P)-binding; Region: NAD_binding_10; pfam13460 290315006528 NAD(P) binding site [chemical binding]; other site 290315006529 putative active site [active] 290315006530 rod shape-determining protein MreB; Provisional; Region: PRK13930 290315006531 MreB and similar proteins; Region: MreB_like; cd10225 290315006532 nucleotide binding site [chemical binding]; other site 290315006533 Mg binding site [ion binding]; other site 290315006534 putative protofilament interaction site [polypeptide binding]; other site 290315006535 RodZ interaction site [polypeptide binding]; other site 290315006536 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 290315006537 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 290315006538 PhnA protein; Region: PhnA; pfam03831 290315006539 GTPase RsgA; Reviewed; Region: PRK01889 290315006540 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 290315006541 GTPase/Zn-binding domain interface [polypeptide binding]; other site 290315006542 GTP/Mg2+ binding site [chemical binding]; other site 290315006543 G4 box; other site 290315006544 G5 box; other site 290315006545 G1 box; other site 290315006546 Switch I region; other site 290315006547 G2 box; other site 290315006548 G3 box; other site 290315006549 Switch II region; other site 290315006550 mobile mystery protein B; Region: mob_myst_B; TIGR02613 290315006551 Fic/DOC family; Region: Fic; pfam02661 290315006552 mobile mystery protein A; Region: mob_myst_A; TIGR02612 290315006553 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 290315006554 non-specific DNA binding site [nucleotide binding]; other site 290315006555 salt bridge; other site 290315006556 sequence-specific DNA binding site [nucleotide binding]; other site 290315006557 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 290315006558 dimer interface [polypeptide binding]; other site 290315006559 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 290315006560 FMN binding site [chemical binding]; other site 290315006561 dimer interface [polypeptide binding]; other site 290315006562 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290315006563 S-adenosylmethionine binding site [chemical binding]; other site 290315006564 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 290315006565 CoenzymeA binding site [chemical binding]; other site 290315006566 subunit interaction site [polypeptide binding]; other site 290315006567 PHB binding site; other site 290315006568 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 290315006569 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 290315006570 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 290315006571 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 290315006572 SEC-C motif; Region: SEC-C; pfam02810 290315006573 Predicted esterase [General function prediction only]; Region: COG0400 290315006574 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290315006575 putative DNA binding site [nucleotide binding]; other site 290315006576 dimerization interface [polypeptide binding]; other site 290315006577 putative Zn2+ binding site [ion binding]; other site 290315006578 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290315006579 ATP binding site [chemical binding]; other site 290315006580 Mg2+ binding site [ion binding]; other site 290315006581 G-X-G motif; other site 290315006582 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 290315006583 TIR domain; Region: TIR_2; pfam13676 290315006584 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 290315006585 Transposase domain (DUF772); Region: DUF772; pfam05598 290315006586 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 290315006587 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 290315006588 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446 290315006589 GIY-YIG motif/motif A; other site 290315006590 putative active site [active] 290315006591 putative metal binding site [ion binding]; other site 290315006592 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 290315006593 active site 290315006594 catalytic site [active] 290315006595 substrate binding site [chemical binding]; other site 290315006596 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 290315006597 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 290315006598 Divergent AAA domain; Region: AAA_4; pfam04326 290315006599 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 290315006600 Transposase domain (DUF772); Region: DUF772; pfam05598 290315006601 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 290315006602 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 290315006603 Bacterial Ig-like domain; Region: Big_5; pfam13205 290315006604 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 290315006605 nucleophilic elbow; other site 290315006606 catalytic triad; other site 290315006607 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 290315006608 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 290315006609 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 290315006610 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 290315006611 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 290315006612 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 290315006613 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 290315006614 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 290315006615 Walker A/P-loop; other site 290315006616 ATP binding site [chemical binding]; other site 290315006617 Q-loop/lid; other site 290315006618 ABC transporter signature motif; other site 290315006619 Walker B; other site 290315006620 D-loop; other site 290315006621 H-loop/switch region; other site 290315006622 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 290315006623 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 290315006624 HlyD family secretion protein; Region: HlyD_3; pfam13437 290315006625 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 290315006626 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 290315006627 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 290315006628 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 290315006629 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290315006630 putative homodimer interface [polypeptide binding]; other site 290315006631 Methyltransferase domain; Region: Methyltransf_23; pfam13489 290315006632 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 290315006633 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 290315006634 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 290315006635 Probable Catalytic site; other site 290315006636 metal-binding site 290315006637 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 290315006638 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 290315006639 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 290315006640 dimerization domain swap beta strand [polypeptide binding]; other site 290315006641 regulatory protein interface [polypeptide binding]; other site 290315006642 active site 290315006643 regulatory phosphorylation site [posttranslational modification]; other site 290315006644 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 290315006645 Coenzyme A binding pocket [chemical binding]; other site 290315006646 GTPase CgtA; Reviewed; Region: obgE; PRK12299 290315006647 GTP1/OBG; Region: GTP1_OBG; pfam01018 290315006648 Obg GTPase; Region: Obg; cd01898 290315006649 G1 box; other site 290315006650 GTP/Mg2+ binding site [chemical binding]; other site 290315006651 Switch I region; other site 290315006652 G2 box; other site 290315006653 G3 box; other site 290315006654 Switch II region; other site 290315006655 G4 box; other site 290315006656 G5 box; other site 290315006657 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 290315006658 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 290315006659 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 290315006660 GatB domain; Region: GatB_Yqey; smart00845 290315006661 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 290315006662 Clp amino terminal domain; Region: Clp_N; pfam02861 290315006663 Clp amino terminal domain; Region: Clp_N; pfam02861 290315006664 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290315006665 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 290315006666 Walker A motif; other site 290315006667 ATP binding site [chemical binding]; other site 290315006668 Walker B motif; other site 290315006669 arginine finger; other site 290315006670 von Willebrand factor type A domain; Region: VWA_2; pfam13519 290315006671 metal ion-dependent adhesion site (MIDAS); other site 290315006672 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 290315006673 metal ion-dependent adhesion site (MIDAS); other site 290315006674 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 290315006675 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 290315006676 metal ion-dependent adhesion site (MIDAS); other site 290315006677 MoxR-like ATPases [General function prediction only]; Region: COG0714 290315006678 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290315006679 Walker A motif; other site 290315006680 ATP binding site [chemical binding]; other site 290315006681 Walker B motif; other site 290315006682 arginine finger; other site 290315006683 UGMP family protein; Validated; Region: PRK09604 290315006684 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 290315006685 Preprotein translocase subunit; Region: YajC; pfam02699 290315006686 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 290315006687 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 290315006688 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 290315006689 catalytic site [active] 290315006690 subunit interface [polypeptide binding]; other site 290315006691 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 290315006692 homodimer interface [polypeptide binding]; other site 290315006693 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290315006694 catalytic residue [active] 290315006695 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 290315006696 TPR motif; other site 290315006697 binding surface 290315006698 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 290315006699 B12 binding site [chemical binding]; other site 290315006700 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 290315006701 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290315006702 FeS/SAM binding site; other site 290315006703 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 290315006704 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 290315006705 Uncharacterized conserved protein [Function unknown]; Region: COG4095 290315006706 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 290315006707 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 290315006708 Oxygen tolerance; Region: BatD; pfam13584 290315006709 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 290315006710 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 290315006711 dimer interface [polypeptide binding]; other site 290315006712 putative functional site; other site 290315006713 putative MPT binding site; other site 290315006714 bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604 290315006715 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 290315006716 trimer interface [polypeptide binding]; other site 290315006717 dimer interface [polypeptide binding]; other site 290315006718 putative active site [active] 290315006719 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 290315006720 MPT binding site; other site 290315006721 trimer interface [polypeptide binding]; other site 290315006722 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 290315006723 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 290315006724 active site 290315006725 catalytic site [active] 290315006726 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 290315006727 putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MobA; Provisional; Region: PRK14490 290315006728 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 290315006729 Walker A motif; other site 290315006730 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 290315006731 GTP binding site; other site 290315006732 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290315006733 Ligand Binding Site [chemical binding]; other site 290315006734 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 290315006735 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 290315006736 ABC-ATPase subunit interface; other site 290315006737 dimer interface [polypeptide binding]; other site 290315006738 putative PBP binding regions; other site 290315006739 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 290315006740 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 290315006741 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 290315006742 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 290315006743 putative metal binding residues [ion binding]; other site 290315006744 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 290315006745 metal binding site 2 [ion binding]; metal-binding site 290315006746 putative DNA binding helix; other site 290315006747 metal binding site 1 [ion binding]; metal-binding site 290315006748 dimer interface [polypeptide binding]; other site 290315006749 structural Zn2+ binding site [ion binding]; other site 290315006750 2-isopropylmalate synthase; Validated; Region: PRK03739 290315006751 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 290315006752 active site 290315006753 catalytic residues [active] 290315006754 metal binding site [ion binding]; metal-binding site 290315006755 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 290315006756 META domain; Region: META; pfam03724 290315006757 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 290315006758 ABC-2 type transporter; Region: ABC2_membrane; cl17235 290315006759 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 290315006760 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 290315006761 Walker A/P-loop; other site 290315006762 ATP binding site [chemical binding]; other site 290315006763 Q-loop/lid; other site 290315006764 ABC transporter signature motif; other site 290315006765 Walker B; other site 290315006766 D-loop; other site 290315006767 H-loop/switch region; other site 290315006768 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290315006769 dimerization interface [polypeptide binding]; other site 290315006770 putative DNA binding site [nucleotide binding]; other site 290315006771 putative Zn2+ binding site [ion binding]; other site 290315006772 Transglycosylase; Region: Transgly; pfam00912 290315006773 Cytochrome c; Region: Cytochrom_C; pfam00034 290315006774 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 290315006775 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 290315006776 ATP binding site [chemical binding]; other site 290315006777 Mg2+ binding site [ion binding]; other site 290315006778 G-X-G motif; other site 290315006779 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 290315006780 ATP binding site [chemical binding]; other site 290315006781 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 290315006782 competence damage-inducible protein A; Provisional; Region: PRK00549 290315006783 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 290315006784 putative MPT binding site; other site 290315006785 Competence-damaged protein; Region: CinA; pfam02464 290315006786 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 290315006787 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 290315006788 nucleotide binding site [chemical binding]; other site 290315006789 substrate binding site [chemical binding]; other site 290315006790 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 290315006791 dimer interface [polypeptide binding]; other site 290315006792 putative threonine allosteric regulatory site; other site 290315006793 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 290315006794 putative threonine allosteric regulatory site; other site 290315006795 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 290315006796 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 290315006797 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 290315006798 core domain interface [polypeptide binding]; other site 290315006799 delta subunit interface [polypeptide binding]; other site 290315006800 epsilon subunit interface [polypeptide binding]; other site 290315006801 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 290315006802 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 290315006803 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 290315006804 beta subunit interaction interface [polypeptide binding]; other site 290315006805 Walker A motif; other site 290315006806 ATP binding site [chemical binding]; other site 290315006807 Walker B motif; other site 290315006808 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 290315006809 homoserine kinase; Provisional; Region: PRK01212 290315006810 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 290315006811 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 290315006812 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 290315006813 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290315006814 catalytic residue [active] 290315006815 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 290315006816 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 290315006817 putative acyl-acceptor binding pocket; other site 290315006818 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 290315006819 homopentamer interface [polypeptide binding]; other site 290315006820 active site 290315006821 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 290315006822 dimer interface [polypeptide binding]; other site 290315006823 active site 290315006824 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290315006825 Ligand Binding Site [chemical binding]; other site 290315006826 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 290315006827 Ligand Binding Site [chemical binding]; other site 290315006828 Ion transport protein; Region: Ion_trans; pfam00520 290315006829 Ion channel; Region: Ion_trans_2; pfam07885 290315006830 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 290315006831 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 290315006832 substrate binding site [chemical binding]; other site 290315006833 active site 290315006834 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 290315006835 Cysteine-rich domain; Region: CCG; pfam02754 290315006836 Cysteine-rich domain; Region: CCG; pfam02754 290315006837 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 290315006838 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 290315006839 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 290315006840 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 290315006841 L-aspartate oxidase; Provisional; Region: PRK06175 290315006842 succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812 290315006843 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 290315006844 FOG: CBS domain [General function prediction only]; Region: COG0517 290315006845 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 290315006846 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 290315006847 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 290315006848 Protein export membrane protein; Region: SecD_SecF; cl14618 290315006849 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 290315006850 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 290315006851 putative homodimer interface [polypeptide binding]; other site 290315006852 putative homotetramer interface [polypeptide binding]; other site 290315006853 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 290315006854 putative allosteric switch controlling residues; other site 290315006855 putative metal binding site [ion binding]; other site 290315006856 putative homodimer-homodimer interface [polypeptide binding]; other site 290315006857 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 290315006858 Phosphotransferase enzyme family; Region: APH; pfam01636 290315006859 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 290315006860 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 290315006861 Substrate binding site; other site 290315006862 metal-binding site 290315006863 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 290315006864 N-terminal domain interface [polypeptide binding]; other site 290315006865 sulfate 1 binding site; other site 290315006866 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 290315006867 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493 290315006868 Na binding site [ion binding]; other site 290315006869 Bacteriochlorophyll C binding protein; Region: Bac_chlorC; pfam02043 290315006870 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 290315006871 NADH(P)-binding; Region: NAD_binding_10; pfam13460 290315006872 NAD(P) binding site [chemical binding]; other site 290315006873 putative active site [active] 290315006874 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 290315006875 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 290315006876 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 290315006877 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 290315006878 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 290315006879 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 290315006880 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 290315006881 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 290315006882 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 290315006883 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 290315006884 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 290315006885 P loop; other site 290315006886 Nucleotide binding site [chemical binding]; other site 290315006887 DTAP/Switch II; other site 290315006888 Switch I; other site 290315006889 TPR repeat; Region: TPR_11; pfam13414 290315006890 TPR repeat; Region: TPR_11; pfam13414 290315006891 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290315006892 binding surface 290315006893 TPR motif; other site 290315006894 TPR repeat; Region: TPR_11; pfam13414 290315006895 TPR repeat; Region: TPR_11; pfam13414 290315006896 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 290315006897 binding surface 290315006898 TPR motif; other site 290315006899 TPR repeat; Region: TPR_11; pfam13414 290315006900 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 290315006901 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 290315006902 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 290315006903 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 290315006904 Methyltransferase domain; Region: Methyltransf_23; pfam13489 290315006905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290315006906 S-adenosylmethionine binding site [chemical binding]; other site 290315006907 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 290315006908 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 290315006909 classical (c) SDRs; Region: SDR_c; cd05233 290315006910 NAD(P) binding site [chemical binding]; other site 290315006911 active site 290315006912 Uncharacterized conserved protein [Function unknown]; Region: COG2353 290315006913 four helix bundle suffix domain; Region: 4helix_suffix; TIGR04258 290315006914 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 290315006915 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 290315006916 trmE is a tRNA modification GTPase; Region: trmE; cd04164 290315006917 G1 box; other site 290315006918 GTP/Mg2+ binding site [chemical binding]; other site 290315006919 Switch I region; other site 290315006920 G2 box; other site 290315006921 Switch II region; other site 290315006922 G3 box; other site 290315006923 G4 box; other site 290315006924 G5 box; other site 290315006925 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 290315006926 short chain dehydrogenase; Provisional; Region: PRK07326 290315006927 classical (c) SDRs; Region: SDR_c; cd05233 290315006928 NAD(P) binding site [chemical binding]; other site 290315006929 active site 290315006930 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 290315006931 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 290315006932 homodimer interface [polypeptide binding]; other site 290315006933 metal binding site [ion binding]; metal-binding site 290315006934 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 290315006935 homodimer interface [polypeptide binding]; other site 290315006936 active site 290315006937 putative chemical substrate binding site [chemical binding]; other site 290315006938 metal binding site [ion binding]; metal-binding site 290315006939 Predicted esterase [General function prediction only]; Region: COG0400 290315006940 trehalose synthase; Region: treS_nterm; TIGR02456 290315006941 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 290315006942 active site 290315006943 catalytic site [active] 290315006944 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 290315006945 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 290315006946 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 290315006947 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 290315006948 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 290315006949 active site 290315006950 homodimer interface [polypeptide binding]; other site 290315006951 catalytic site [active] 290315006952 acceptor binding site [chemical binding]; other site 290315006953 PCRF domain; Region: PCRF; pfam03462 290315006954 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 290315006955 RF-1 domain; Region: RF-1; pfam00472 290315006956 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 290315006957 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 290315006958 active site 290315006959 metal binding site [ion binding]; metal-binding site 290315006960 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 290315006961 Peptidase family M23; Region: Peptidase_M23; pfam01551 290315006962 peptide modification radical SAM enzyme, YydG family; Region: rSAM_yydG; TIGR04078 290315006963 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290315006964 FeS/SAM binding site; other site 290315006965 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 290315006966 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 290315006967 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 290315006968 ligand binding site [chemical binding]; other site 290315006969 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 290315006970 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 290315006971 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 290315006972 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 290315006973 homodimer interface [polypeptide binding]; other site 290315006974 active site 290315006975 OstA-like protein; Region: OstA_2; pfam13100 290315006976 OstA-like protein; Region: OstA; cl00844 290315006977 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 290315006978 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 290315006979 Recombination protein O N terminal; Region: RecO_N; pfam11967 290315006980 Recombination protein O C terminal; Region: RecO_C; pfam02565 290315006981 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 290315006982 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290315006983 inhibitor-cofactor binding pocket; inhibition site 290315006984 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290315006985 catalytic residue [active] 290315006986 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 290315006987 camphor resistance protein CrcB; Provisional; Region: PRK14202 290315006988 thiosulfate reductase PhsA; Provisional; Region: PRK15488 290315006989 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 290315006990 putative [Fe4-S4] binding site [ion binding]; other site 290315006991 putative molybdopterin cofactor binding site [chemical binding]; other site 290315006992 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 290315006993 molybdopterin cofactor binding site; other site 290315006994 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 290315006995 4Fe-4S binding domain; Region: Fer4; cl02805 290315006996 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 290315006997 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 290315006998 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 290315006999 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 290315007000 active site 290315007001 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 290315007002 prephenate dehydrogenase; Validated; Region: PRK08507 290315007003 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 290315007004 ATP-NAD kinase; Region: NAD_kinase; pfam01513 290315007005 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 290315007006 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 290315007007 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 290315007008 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 290315007009 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 290315007010 Walker A motif; other site 290315007011 ATP binding site [chemical binding]; other site 290315007012 Walker B motif; other site 290315007013 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 290315007014 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 290315007015 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 290315007016 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 290315007017 catalytic core [active] 290315007018 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 290315007019 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 290315007020 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 290315007021 membrane protein; Provisional; Region: PRK14410 290315007022 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 290315007023 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 290315007024 dimerization interface [polypeptide binding]; other site 290315007025 putative ATP binding site [chemical binding]; other site 290315007026 aspartate kinase III; Validated; Region: PRK09084 290315007027 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 290315007028 nucleotide binding site [chemical binding]; other site 290315007029 substrate binding site [chemical binding]; other site 290315007030 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 290315007031 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 290315007032 NlpC/P60 family; Region: NLPC_P60; pfam00877 290315007033 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 290315007034 Methyltransferase domain; Region: Methyltransf_18; pfam12847 290315007035 exopolyphosphatase; Region: exo_poly_only; TIGR03706 290315007036 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 290315007037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290315007038 S-adenosylmethionine binding site [chemical binding]; other site 290315007039 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 290315007040 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 290315007041 acyl-activating enzyme (AAE) consensus motif; other site 290315007042 putative AMP binding site [chemical binding]; other site 290315007043 putative active site [active] 290315007044 putative CoA binding site [chemical binding]; other site 290315007045 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 290315007046 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 290315007047 inhibitor-cofactor binding pocket; inhibition site 290315007048 pyridoxal 5'-phosphate binding site [chemical binding]; other site 290315007049 catalytic residue [active] 290315007050 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 290315007051 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 290315007052 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 290315007053 ADP binding site [chemical binding]; other site 290315007054 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 290315007055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290315007056 S-adenosylmethionine binding site [chemical binding]; other site 290315007057 Protein of unknown function (DUF452); Region: DUF452; cl01062 290315007058 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 290315007059 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 290315007060 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 290315007061 catalytic residue [active] 290315007062 biotin synthase; Region: bioB; TIGR00433 290315007063 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 290315007064 FeS/SAM binding site; other site 290315007065 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 290315007066 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 290315007067 putative DNA binding site [nucleotide binding]; other site 290315007068 putative Zn2+ binding site [ion binding]; other site 290315007069 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 290315007070 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 290315007071 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 290315007072 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 290315007073 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 290315007074 active site 290315007075 metal binding site [ion binding]; metal-binding site 290315007076 DNA topoisomerase I; Validated; Region: PRK06599 290315007077 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 290315007078 active site 290315007079 interdomain interaction site; other site 290315007080 putative metal-binding site [ion binding]; other site 290315007081 nucleotide binding site [chemical binding]; other site 290315007082 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 290315007083 domain I; other site 290315007084 DNA binding groove [nucleotide binding] 290315007085 phosphate binding site [ion binding]; other site 290315007086 domain II; other site 290315007087 domain III; other site 290315007088 nucleotide binding site [chemical binding]; other site 290315007089 catalytic site [active] 290315007090 domain IV; other site 290315007091 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 290315007092 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 290315007093 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 290315007094 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 290315007095 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 290315007096 G1 box; other site 290315007097 GTP/Mg2+ binding site [chemical binding]; other site 290315007098 Switch I region; other site 290315007099 G2 box; other site 290315007100 G3 box; other site 290315007101 Switch II region; other site 290315007102 G4 box; other site 290315007103 G5 box; other site 290315007104 Nucleoside recognition; Region: Gate; pfam07670 290315007105 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 290315007106 Nucleoside recognition; Region: Gate; pfam07670 290315007107 FeoA domain; Region: FeoA; pfam04023 290315007108 aconitate hydratase; Validated; Region: PRK09277 290315007109 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 290315007110 substrate binding site [chemical binding]; other site 290315007111 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 290315007112 ligand binding site [chemical binding]; other site 290315007113 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 290315007114 substrate binding site [chemical binding]; other site 290315007115 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 290315007116 nucleotide binding site/active site [active] 290315007117 HIT family signature motif; other site 290315007118 catalytic residue [active] 290315007119 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 290315007120 Domain of unknown function DUF21; Region: DUF21; pfam01595 290315007121 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 290315007122 Transporter associated domain; Region: CorC_HlyC; smart01091 290315007123 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; pfam09603 290315007124 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 290315007125 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 290315007126 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 290315007127 L-aspartate oxidase; Provisional; Region: PRK06175 290315007128 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 290315007129 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 290315007130 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 290315007131 putative Iron-sulfur protein interface [polypeptide binding]; other site 290315007132 proximal heme binding site [chemical binding]; other site 290315007133 distal heme binding site [chemical binding]; other site 290315007134 putative dimer interface [polypeptide binding]; other site 290315007135 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 290315007136 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 290315007137 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 290315007138 phosphate binding site [ion binding]; other site 290315007139 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 290315007140 putative hydrophobic ligand binding site [chemical binding]; other site 290315007141 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 290315007142 active site 290315007143 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 290315007144 Esterase/lipase [General function prediction only]; Region: COG1647 290315007145 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 290315007146 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 290315007147 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 290315007148 Protein of unknown function DUF89; Region: DUF89; cl15397 290315007149 Predicted transcriptional regulator [General function prediction only]; Region: COG2522 290315007150 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 290315007151 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 290315007152 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 290315007153 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 290315007154 AAA domain; Region: AAA_33; pfam13671 290315007155 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 290315007156 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 290315007157 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 290315007158 putative active site [active] 290315007159 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 290315007160 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 290315007161 ATP binding site [chemical binding]; other site 290315007162 putative Mg++ binding site [ion binding]; other site 290315007163 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 290315007164 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 290315007165 Divergent AAA domain; Region: AAA_4; pfam04326 290315007166 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 290315007167 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 290315007168 Transposase domain (DUF772); Region: DUF772; pfam05598 290315007169 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 290315007170 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 290315007171 Domain of unknown function DUF87; Region: DUF87; pfam01935 290315007172 HerA helicase [Replication, recombination, and repair]; Region: COG0433 290315007173 Zonular occludens toxin (Zot); Region: Zot; cl17485 290315007174 SIR2-like domain; Region: SIR2_2; pfam13289 290315007175 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 290315007176 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 290315007177 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 290315007178 BRO family, N-terminal domain; Region: Bro-N; pfam02498 290315007179 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 290315007180 HsdM N-terminal domain; Region: HsdM_N; pfam12161 290315007181 Methyltransferase domain; Region: Methyltransf_26; pfam13659 290315007182 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 290315007183 AAA domain; Region: AAA_22; pfam13401 290315007184 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 290315007185 Domain of unknown function (DUF955); Region: DUF955; cl01076 290315007186 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 290315007187 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 290315007188 active site 290315007189 intersubunit interactions; other site 290315007190 catalytic residue [active] 290315007191 deoxyhypusine synthase-like protein; Provisional; Region: PRK02492 290315007192 deoxyhypusine synthase; Region: dhys; TIGR00321 290315007193 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 290315007194 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 290315007195 active site 290315007196 HIGH motif; other site 290315007197 dimer interface [polypeptide binding]; other site 290315007198 KMSKS motif; other site 290315007199 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 290315007200 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 290315007201 active site 290315007202 motif I; other site 290315007203 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 290315007204 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 290315007205 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 290315007206 active site 290315007207 HIGH motif; other site 290315007208 KMSK motif region; other site 290315007209 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 290315007210 tRNA binding surface [nucleotide binding]; other site 290315007211 anticodon binding site; other site 290315007212 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 290315007213 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 290315007214 active site 290315007215 (T/H)XGH motif; other site 290315007216 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 290315007217 DsrE/DsrF-like family; Region: DrsE; pfam02635 290315007218 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 290315007219 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 290315007220 F0F1 ATP synthase subunit B; Provisional; Region: PRK14472 290315007221 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 290315007222 ATP synthase subunit C; Region: ATP-synt_C; cl00466 290315007223 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 290315007224 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 290315007225 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 290315007226 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 290315007227 O-methyltransferase; Region: Methyltransf_2; pfam00891 290315007228 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 290315007229 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 290315007230 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 290315007231 cell division protein FtsZ; Validated; Region: PRK09330 290315007232 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 290315007233 nucleotide binding site [chemical binding]; other site 290315007234 SulA interaction site; other site 290315007235 cell division protein FtsA; Region: ftsA; TIGR01174 290315007236 Cell division protein FtsA; Region: FtsA; smart00842 290315007237 Cell division protein FtsA; Region: FtsA; pfam14450 290315007238 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 290315007239 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 290315007240 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 290315007241 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 290315007242 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290315007243 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290315007244 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 290315007245 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 290315007246 active site 290315007247 homodimer interface [polypeptide binding]; other site 290315007248 cell division protein FtsW; Region: ftsW; TIGR02614 290315007249 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 290315007250 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290315007251 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290315007252 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 290315007253 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 290315007254 Mg++ binding site [ion binding]; other site 290315007255 putative catalytic motif [active] 290315007256 putative substrate binding site [chemical binding]; other site 290315007257 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 290315007258 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 290315007259 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290315007260 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290315007261 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 290315007262 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 290315007263 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 290315007264 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 290315007265 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 290315007266 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 290315007267 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 290315007268 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 290315007269 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 290315007270 MraW methylase family; Region: Methyltransf_5; cl17771 290315007271 cell division protein MraZ; Reviewed; Region: PRK00326 290315007272 MraZ protein; Region: MraZ; pfam02381 290315007273 MraZ protein; Region: MraZ; pfam02381 290315007274 YacP-like NYN domain; Region: NYN_YacP; pfam05991 290315007275 Chorismate mutase type II; Region: CM_2; pfam01817 290315007276 YceG-like family; Region: YceG; pfam02618 290315007277 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 290315007278 dimerization interface [polypeptide binding]; other site 290315007279 Phosphoglycerate kinase; Region: PGK; pfam00162 290315007280 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 290315007281 substrate binding site [chemical binding]; other site 290315007282 hinge regions; other site 290315007283 ADP binding site [chemical binding]; other site 290315007284 catalytic site [active] 290315007285 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 290315007286 Uncharacterized conserved protein [Function unknown]; Region: COG3339 290315007287 TRAM domain; Region: TRAM; pfam01938 290315007288 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 290315007289 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 290315007290 S-adenosylmethionine binding site [chemical binding]; other site 290315007291 fructokinase; Reviewed; Region: PRK09557 290315007292 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 290315007293 nucleotide binding site [chemical binding]; other site 290315007294 PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395 290315007295 active site 290315007296 membrane protein insertase; Provisional; Region: PRK01318 290315007297 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 290315007298 Haemolytic domain; Region: Haemolytic; pfam01809 290315007299 ribonuclease P; Reviewed; Region: rnpA; PRK01903 290315007300 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399