-- dump date 20140619_041148 -- class Genbank::misc_feature -- table misc_feature_note -- id note 331678000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 331678000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 331678000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678000004 Walker A motif; other site 331678000005 ATP binding site [chemical binding]; other site 331678000006 Walker B motif; other site 331678000007 arginine finger; other site 331678000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 331678000009 DnaA box-binding interface [nucleotide binding]; other site 331678000010 DNA polymerase III subunit beta; Provisional; Region: PRK14941 331678000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 331678000012 putative DNA binding surface [nucleotide binding]; other site 331678000013 dimer interface [polypeptide binding]; other site 331678000014 beta-clamp/clamp loader binding surface; other site 331678000015 beta-clamp/translesion DNA polymerase binding surface; other site 331678000016 recombination protein F; Reviewed; Region: recF; PRK00064 331678000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331678000018 Walker A/P-loop; other site 331678000019 ATP binding site [chemical binding]; other site 331678000020 Q-loop/lid; other site 331678000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331678000022 ABC transporter signature motif; other site 331678000023 Walker B; other site 331678000024 D-loop; other site 331678000025 H-loop/switch region; other site 331678000026 Protein of unknown function (DUF721); Region: DUF721; pfam05258 331678000027 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 331678000028 Peptidase family M50; Region: Peptidase_M50; pfam02163 331678000029 active site 331678000030 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 331678000031 putative substrate binding region [chemical binding]; other site 331678000032 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 331678000033 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 331678000034 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 331678000035 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like2_exo; cd05785 331678000036 DNA polymerase type-B family; Region: POLBc; smart00486 331678000037 active site 331678000038 catalytic site [active] 331678000039 substrate binding site [chemical binding]; other site 331678000040 DNA polymerase type-II B subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II_B; cd05538 331678000041 active site 331678000042 metal-binding site 331678000043 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 331678000044 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 331678000045 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 331678000046 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 331678000047 Cytochrome c; Region: Cytochrom_C; cl11414 331678000048 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 331678000049 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 331678000050 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 331678000051 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 331678000052 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 331678000053 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 331678000054 Protein export membrane protein; Region: SecD_SecF; pfam02355 331678000055 SurA N-terminal domain; Region: SurA_N; pfam09312 331678000056 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 331678000057 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 331678000058 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 331678000059 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331678000060 ATP binding site [chemical binding]; other site 331678000061 Mg2+ binding site [ion binding]; other site 331678000062 G-X-G motif; other site 331678000063 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 331678000064 anchoring element; other site 331678000065 dimer interface [polypeptide binding]; other site 331678000066 ATP binding site [chemical binding]; other site 331678000067 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 331678000068 active site 331678000069 putative metal-binding site [ion binding]; other site 331678000070 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 331678000071 hypothetical protein; Reviewed; Region: PRK12497 331678000072 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 331678000073 RNA/DNA hybrid binding site [nucleotide binding]; other site 331678000074 active site 331678000075 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 331678000076 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 331678000077 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 331678000078 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 331678000079 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 331678000080 trimer interface [polypeptide binding]; other site 331678000081 active site 331678000082 substrate binding site [chemical binding]; other site 331678000083 CoA binding site [chemical binding]; other site 331678000084 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 331678000085 C-terminal peptidase (prc); Region: prc; TIGR00225 331678000086 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 331678000087 protein binding site [polypeptide binding]; other site 331678000088 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 331678000089 Catalytic dyad [active] 331678000090 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 331678000091 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 331678000092 geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023 331678000093 glycyl-tRNA synthetase; Provisional; Region: PRK04173 331678000094 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 331678000095 motif 1; other site 331678000096 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 331678000097 active site 331678000098 motif 2; other site 331678000099 motif 3; other site 331678000100 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 331678000101 anticodon binding site; other site 331678000102 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 331678000103 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 331678000104 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 331678000105 catalytic residue [active] 331678000106 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 331678000107 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 331678000108 dimer interface [polypeptide binding]; other site 331678000109 catalytic triad [active] 331678000110 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 331678000111 gamma subunit interface [polypeptide binding]; other site 331678000112 epsilon subunit interface [polypeptide binding]; other site 331678000113 LBP interface [polypeptide binding]; other site 331678000114 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 331678000115 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 331678000116 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 331678000117 alpha subunit interaction interface [polypeptide binding]; other site 331678000118 Walker A motif; other site 331678000119 ATP binding site [chemical binding]; other site 331678000120 Walker B motif; other site 331678000121 inhibitor binding site; inhibition site 331678000122 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 331678000123 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 331678000124 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 331678000125 catalytic residues [active] 331678000126 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 331678000127 active site 331678000128 substrate-binding site [chemical binding]; other site 331678000129 metal-binding site [ion binding] 331678000130 GTP binding site [chemical binding]; other site 331678000131 Dodecin; Region: Dodecin; pfam07311 331678000132 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 331678000133 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 331678000134 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 331678000135 P-loop; other site 331678000136 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 331678000137 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 331678000138 Na2 binding site [ion binding]; other site 331678000139 putative substrate binding site 1 [chemical binding]; other site 331678000140 Na binding site 1 [ion binding]; other site 331678000141 putative substrate binding site 2 [chemical binding]; other site 331678000142 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 331678000143 DNA methylase; Region: N6_N4_Mtase; pfam01555 331678000144 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 331678000145 Catalytic site; other site 331678000146 MjaI restriction endonuclease; Region: RE_MjaI; pfam09568 331678000147 Transposase [DNA replication, recombination, and repair]; Region: COG5421 331678000148 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 331678000149 CHAP domain; Region: CHAP; cl17642 331678000150 Surface antigen [General function prediction only]; Region: COG3942 331678000151 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 331678000152 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 331678000153 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 331678000154 Homeodomain-like domain; Region: HTH_23; pfam13384 331678000155 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 331678000156 Integrase core domain; Region: rve; pfam00665 331678000157 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 331678000158 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678000159 Walker A motif; other site 331678000160 ATP binding site [chemical binding]; other site 331678000161 Walker B motif; other site 331678000162 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 331678000163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 331678000164 Protein of unknown function (DUF433); Region: DUF433; cl01030 331678000165 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 331678000166 oligomeric interface; other site 331678000167 putative active site [active] 331678000168 homodimer interface [polypeptide binding]; other site 331678000169 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 331678000170 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 331678000171 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 331678000172 active site 331678000173 AAA domain; Region: AAA_14; pfam13173 331678000174 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 331678000175 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 331678000176 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 331678000177 active site 331678000178 NTP binding site [chemical binding]; other site 331678000179 metal binding triad [ion binding]; metal-binding site 331678000180 antibiotic binding site [chemical binding]; other site 331678000181 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 331678000182 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 331678000183 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 331678000184 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 331678000185 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 331678000186 ATP binding site [chemical binding]; other site 331678000187 putative Mg++ binding site [ion binding]; other site 331678000188 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 331678000189 nucleotide binding region [chemical binding]; other site 331678000190 ATP-binding site [chemical binding]; other site 331678000191 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 331678000192 HRDC domain; Region: HRDC; pfam00570 331678000193 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 331678000194 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678000195 FeS/SAM binding site; other site 331678000196 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 331678000197 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 331678000198 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 331678000199 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 331678000200 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 331678000201 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12509 331678000202 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12659 331678000203 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 331678000204 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 331678000205 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 331678000206 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 331678000207 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 331678000208 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 331678000209 xylose isomerase; Region: xylose_isom_A; TIGR02630 331678000210 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 331678000211 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 331678000212 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 331678000213 TrkA-N domain; Region: TrkA_N; pfam02254 331678000214 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 331678000215 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 331678000216 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 331678000217 TrkA-N domain; Region: TrkA_N; pfam02254 331678000218 TrkA-C domain; Region: TrkA_C; pfam02080 331678000219 TrkA-N domain; Region: TrkA_N; pfam02254 331678000220 TrkA-C domain; Region: TrkA_C; pfam02080 331678000221 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 331678000222 SelR domain; Region: SelR; pfam01641 331678000223 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 331678000224 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 331678000225 DTAP/Switch II; other site 331678000226 Switch I; other site 331678000227 Ion channel; Region: Ion_trans_2; pfam07885 331678000228 peptide chain release factor 1; Validated; Region: prfA; PRK00591 331678000229 PCRF domain; Region: PCRF; pfam03462 331678000230 RF-1 domain; Region: RF-1; pfam00472 331678000231 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 331678000232 RIP metalloprotease RseP; Region: TIGR00054 331678000233 active site 331678000234 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 331678000235 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 331678000236 protein binding site [polypeptide binding]; other site 331678000237 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 331678000238 putative substrate binding region [chemical binding]; other site 331678000239 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 331678000240 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 331678000241 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 331678000242 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 331678000243 Acylphosphatase; Region: Acylphosphatase; pfam00708 331678000244 FtsH Extracellular; Region: FtsH_ext; pfam06480 331678000245 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 331678000246 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678000247 Walker B motif; other site 331678000248 arginine finger; other site 331678000249 Peptidase family M41; Region: Peptidase_M41; pfam01434 331678000250 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 331678000251 active site 331678000252 dimer interface [polypeptide binding]; other site 331678000253 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 331678000254 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 331678000255 glutaminase active site [active] 331678000256 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 331678000257 dimer interface [polypeptide binding]; other site 331678000258 active site 331678000259 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 331678000260 dimer interface [polypeptide binding]; other site 331678000261 active site 331678000262 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 331678000263 TIGR01777 family protein; Region: yfcH 331678000264 putative NAD(P) binding site [chemical binding]; other site 331678000265 putative active site [active] 331678000266 DPS-like protein, ferritin-like diiron-binding domain; Region: DPSL; cd01052 331678000267 Ferritin-like domain; Region: Ferritin; pfam00210 331678000268 diiron binding motif [ion binding]; other site 331678000269 Mechanosensitive ion channel; Region: MS_channel; pfam00924 331678000270 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 331678000271 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 331678000272 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 331678000273 Nitrogen regulatory protein P-II; Region: P-II; smart00938 331678000274 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 331678000275 active site 331678000276 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678000277 binding surface 331678000278 TPR repeat; Region: TPR_11; pfam13414 331678000279 TPR motif; other site 331678000280 TPR repeat; Region: TPR_11; pfam13414 331678000281 ScpA/B protein; Region: ScpA_ScpB; cl00598 331678000282 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 331678000283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678000284 S-adenosylmethionine binding site [chemical binding]; other site 331678000285 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 331678000286 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 331678000287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678000288 DNA methylase; Region: N6_N4_Mtase; cl17433 331678000289 Restriction endonuclease XhoI; Region: XhoI; pfam04555 331678000290 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 331678000291 Uncharacterized conserved protein [Function unknown]; Region: COG4198 331678000292 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 331678000293 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 331678000294 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 331678000295 Glycoprotease family; Region: Peptidase_M22; pfam00814 331678000296 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 331678000297 DNA gyrase subunit A; Validated; Region: PRK05560 331678000298 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 331678000299 CAP-like domain; other site 331678000300 active site 331678000301 primary dimer interface [polypeptide binding]; other site 331678000302 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 331678000303 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 331678000304 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 331678000305 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 331678000306 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 331678000307 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 331678000308 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 331678000309 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 331678000310 CTP synthetase; Validated; Region: pyrG; PRK05380 331678000311 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 331678000312 Catalytic site [active] 331678000313 active site 331678000314 UTP binding site [chemical binding]; other site 331678000315 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 331678000316 active site 331678000317 putative oxyanion hole; other site 331678000318 catalytic triad [active] 331678000319 Ferrochelatase; Region: Ferrochelatase; pfam00762 331678000320 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 331678000321 C-terminal domain interface [polypeptide binding]; other site 331678000322 active site 331678000323 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 331678000324 active site 331678000325 N-terminal domain interface [polypeptide binding]; other site 331678000326 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 331678000327 PHP domain; Region: PHP; pfam02811 331678000328 active site 331678000329 four helix bundle suffix domain; Region: 4helix_suffix; TIGR04258 331678000330 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 331678000331 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 331678000332 Putative addiction module component; Region: Unstab_antitox; pfam09720 331678000333 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 331678000334 Integrase core domain; Region: rve; pfam00665 331678000335 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 331678000336 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 331678000337 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678000338 Walker A motif; other site 331678000339 ATP binding site [chemical binding]; other site 331678000340 Walker B motif; other site 331678000341 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 331678000342 Phospholipid methyltransferase; Region: PEMT; cl17370 331678000343 Predicted transcriptional regulator [Transcription]; Region: COG3905 331678000344 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 331678000345 Protein of unknown function DUF45; Region: DUF45; cl00636 331678000346 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678000347 Homeodomain-like domain; Region: HTH_23; pfam13384 331678000348 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 331678000349 Integrase core domain; Region: rve; pfam00665 331678000350 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 331678000351 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 331678000352 dimer interface [polypeptide binding]; other site 331678000353 active site 331678000354 heme binding site [chemical binding]; other site 331678000355 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 331678000356 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 331678000357 metal binding site 2 [ion binding]; metal-binding site 331678000358 putative DNA binding helix; other site 331678000359 metal binding site 1 [ion binding]; metal-binding site 331678000360 dimer interface [polypeptide binding]; other site 331678000361 structural Zn2+ binding site [ion binding]; other site 331678000362 MarC family integral membrane protein; Region: MarC; pfam01914 331678000363 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 331678000364 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; pfam05708 331678000365 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 331678000366 active site 331678000367 Domain of Unknown Function (DUF3856); Region: DUF3856; pfam12968 331678000368 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 331678000369 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 331678000370 putative active site [active] 331678000371 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 331678000372 putative catalytic site [active] 331678000373 putative metal binding site [ion binding]; other site 331678000374 putative phosphate binding site [ion binding]; other site 331678000375 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 331678000376 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 331678000377 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 331678000378 dimer interface [polypeptide binding]; other site 331678000379 ssDNA binding site [nucleotide binding]; other site 331678000380 tetramer (dimer of dimers) interface [polypeptide binding]; other site 331678000381 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 331678000382 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 331678000383 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 331678000384 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 331678000385 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 331678000386 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 331678000387 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 331678000388 dimer interface [polypeptide binding]; other site 331678000389 motif 1; other site 331678000390 active site 331678000391 motif 2; other site 331678000392 motif 3; other site 331678000393 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 331678000394 23S rRNA binding site [nucleotide binding]; other site 331678000395 L21 binding site [polypeptide binding]; other site 331678000396 L13 binding site [polypeptide binding]; other site 331678000397 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 331678000398 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 331678000399 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 331678000400 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 331678000401 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 331678000402 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 331678000403 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 331678000404 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 331678000405 active site 331678000406 dimer interface [polypeptide binding]; other site 331678000407 motif 1; other site 331678000408 motif 2; other site 331678000409 motif 3; other site 331678000410 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 331678000411 anticodon binding site; other site 331678000412 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 331678000413 chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014 331678000414 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 331678000415 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 331678000416 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 331678000417 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 331678000418 active site 331678000419 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 331678000420 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 331678000421 dimerization interface [polypeptide binding]; other site 331678000422 active site 331678000423 metal binding site [ion binding]; metal-binding site 331678000424 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 331678000425 dsRNA binding site [nucleotide binding]; other site 331678000426 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 331678000427 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 331678000428 dimer interface [polypeptide binding]; other site 331678000429 active site 331678000430 acyl carrier protein; Provisional; Region: acpP; PRK00982 331678000431 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 331678000432 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 331678000433 NAD(P) binding site [chemical binding]; other site 331678000434 homotetramer interface [polypeptide binding]; other site 331678000435 homodimer interface [polypeptide binding]; other site 331678000436 active site 331678000437 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 331678000438 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 331678000439 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 331678000440 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 331678000441 dimer interface [polypeptide binding]; other site 331678000442 active site 331678000443 CoA binding pocket [chemical binding]; other site 331678000444 putative phosphate acyltransferase; Provisional; Region: PRK05331 331678000445 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 331678000446 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 331678000447 T5orf172 domain; Region: T5orf172; pfam10544 331678000448 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 331678000449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678000450 S-adenosylmethionine binding site [chemical binding]; other site 331678000451 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 331678000452 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 331678000453 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 331678000454 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 331678000455 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331678000456 non-specific DNA binding site [nucleotide binding]; other site 331678000457 salt bridge; other site 331678000458 sequence-specific DNA binding site [nucleotide binding]; other site 331678000459 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 331678000460 NlpE N-terminal domain; Region: NlpE; pfam04170 331678000461 META domain; Region: META; pfam03724 331678000462 2-isopropylmalate synthase; Validated; Region: PRK03739 331678000463 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 331678000464 active site 331678000465 catalytic residues [active] 331678000466 metal binding site [ion binding]; metal-binding site 331678000467 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 331678000468 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 331678000469 metal binding site 2 [ion binding]; metal-binding site 331678000470 putative DNA binding helix; other site 331678000471 metal binding site 1 [ion binding]; metal-binding site 331678000472 dimer interface [polypeptide binding]; other site 331678000473 structural Zn2+ binding site [ion binding]; other site 331678000474 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 331678000475 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 331678000476 putative metal binding residues [ion binding]; other site 331678000477 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 331678000478 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 331678000479 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 331678000480 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 331678000481 dimer interface [polypeptide binding]; other site 331678000482 putative PBP binding regions; other site 331678000483 ABC-ATPase subunit interface; other site 331678000484 camphor resistance protein CrcB; Provisional; Region: PRK14202 331678000485 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 331678000486 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 331678000487 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 331678000488 inhibitor-cofactor binding pocket; inhibition site 331678000489 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678000490 catalytic residue [active] 331678000491 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 331678000492 Recombination protein O N terminal; Region: RecO_N; pfam11967 331678000493 Recombination protein O C terminal; Region: RecO_C; pfam02565 331678000494 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 331678000495 OstA-like protein; Region: OstA_2; pfam13100 331678000496 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 331678000497 active site 331678000498 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 331678000499 homodimer interface [polypeptide binding]; other site 331678000500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 331678000501 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678000502 FeS/SAM binding site; other site 331678000503 Radical SAM superfamily; Region: Radical_SAM; pfam04055 331678000504 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 331678000505 Protein of unknown function (DUF3946); Region: DUF3946; pfam13102 331678000506 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 331678000507 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 331678000508 active site 331678000509 DNA binding site [nucleotide binding] 331678000510 Int/Topo IB signature motif; other site 331678000511 Helix-turn-helix domain; Region: HTH_17; pfam12728 331678000512 D5 N terminal like; Region: D5_N; pfam08706 331678000513 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 331678000514 Phage terminase, small subunit; Region: Terminase_4; pfam05119 331678000515 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 331678000516 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 331678000517 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 331678000518 NlpC/P60 family; Region: NLPC_P60; pfam00877 331678000519 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 331678000520 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 331678000521 putative active site [active] 331678000522 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 331678000523 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 331678000524 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 331678000525 Peptidase family M23; Region: Peptidase_M23; pfam01551 331678000526 Homo sapiens Nbla03831 and related proteins, metallophosphatase domain; Region: MPP_Nbla03831; cd07396 331678000527 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 331678000528 active site 331678000529 metal binding site [ion binding]; metal-binding site 331678000530 peptide chain release factor 2; Validated; Region: prfB; PRK00578 331678000531 PCRF domain; Region: PCRF; pfam03462 331678000532 RF-1 domain; Region: RF-1; pfam00472 331678000533 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 331678000534 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 331678000535 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 331678000536 active site 331678000537 homodimer interface [polypeptide binding]; other site 331678000538 catalytic site [active] 331678000539 acceptor binding site [chemical binding]; other site 331678000540 trehalose synthase; Region: treS_nterm; TIGR02456 331678000541 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 331678000542 active site 331678000543 catalytic site [active] 331678000544 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 331678000545 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 331678000546 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 331678000547 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 331678000548 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 331678000549 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 331678000550 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331678000551 motif II; other site 331678000552 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 331678000553 Predicted esterase [General function prediction only]; Region: COG0400 331678000554 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 331678000555 active site 331678000556 NTP binding site [chemical binding]; other site 331678000557 metal binding triad [ion binding]; metal-binding site 331678000558 antibiotic binding site [chemical binding]; other site 331678000559 Protein of unknown function DUF86; Region: DUF86; pfam01934 331678000560 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 331678000561 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 331678000562 homodimer interface [polypeptide binding]; other site 331678000563 metal binding site [ion binding]; metal-binding site 331678000564 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 331678000565 homodimer interface [polypeptide binding]; other site 331678000566 active site 331678000567 putative chemical substrate binding site [chemical binding]; other site 331678000568 short chain dehydrogenase; Provisional; Region: PRK07326 331678000569 classical (c) SDRs; Region: SDR_c; cd05233 331678000570 NAD(P) binding site [chemical binding]; other site 331678000571 active site 331678000572 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 331678000573 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 331678000574 trmE is a tRNA modification GTPase; Region: trmE; cd04164 331678000575 G1 box; other site 331678000576 GTP/Mg2+ binding site [chemical binding]; other site 331678000577 Switch I region; other site 331678000578 G2 box; other site 331678000579 Switch II region; other site 331678000580 G3 box; other site 331678000581 G4 box; other site 331678000582 G5 box; other site 331678000583 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 331678000584 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 331678000585 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 331678000586 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 331678000587 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 331678000588 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 331678000589 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 331678000590 P loop; other site 331678000591 Nucleotide binding site [chemical binding]; other site 331678000592 DTAP/Switch II; other site 331678000593 Switch I; other site 331678000594 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 331678000595 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 331678000596 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 331678000597 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 331678000598 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 331678000599 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 331678000600 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 331678000601 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 331678000602 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 331678000603 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 331678000604 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 331678000605 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 331678000606 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 331678000607 EamA-like transporter family; Region: EamA; pfam00892 331678000608 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 331678000609 NADH(P)-binding; Region: NAD_binding_10; pfam13460 331678000610 NAD(P) binding site [chemical binding]; other site 331678000611 putative active site [active] 331678000612 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678000613 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 331678000614 FeS/SAM binding site; other site 331678000615 Methyltransferase domain; Region: Methyltransf_31; pfam13847 331678000616 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678000617 S-adenosylmethionine binding site [chemical binding]; other site 331678000618 Bacteriochlorophyll C binding protein; Region: Bac_chlorC; pfam02043 331678000619 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493 331678000620 Na binding site [ion binding]; other site 331678000621 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 331678000622 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 331678000623 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 331678000624 Substrate binding site; other site 331678000625 metal-binding site 331678000626 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 331678000627 N-terminal domain interface [polypeptide binding]; other site 331678000628 Phosphotransferase enzyme family; Region: APH; pfam01636 331678000629 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 331678000630 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 331678000631 B12 binding site [chemical binding]; other site 331678000632 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 331678000633 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678000634 FeS/SAM binding site; other site 331678000635 2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284 331678000636 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 331678000637 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 331678000638 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 331678000639 classical (c) SDRs; Region: SDR_c; cd05233 331678000640 NAD(P) binding site [chemical binding]; other site 331678000641 active site 331678000642 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 331678000643 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 331678000644 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 331678000645 putative homodimer interface [polypeptide binding]; other site 331678000646 putative homotetramer interface [polypeptide binding]; other site 331678000647 putative allosteric switch controlling residues; other site 331678000648 putative metal binding site [ion binding]; other site 331678000649 putative homodimer-homodimer interface [polypeptide binding]; other site 331678000650 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 331678000651 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 331678000652 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 331678000653 Protein export membrane protein; Region: SecD_SecF; cl14618 331678000654 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 331678000655 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 331678000656 FOG: CBS domain [General function prediction only]; Region: COG0517 331678000657 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 331678000658 L-aspartate oxidase; Provisional; Region: PRK06175 331678000659 succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812 331678000660 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 331678000661 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 331678000662 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 331678000663 catalytic loop [active] 331678000664 iron binding site [ion binding]; other site 331678000665 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 331678000666 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 331678000667 Cysteine-rich domain; Region: CCG; pfam02754 331678000668 Cysteine-rich domain; Region: CCG; pfam02754 331678000669 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 331678000670 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 331678000671 substrate binding site [chemical binding]; other site 331678000672 active site 331678000673 Ion transport protein; Region: Ion_trans; pfam00520 331678000674 Ion channel; Region: Ion_trans_2; pfam07885 331678000675 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 331678000676 Ligand Binding Site [chemical binding]; other site 331678000677 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 331678000678 Ligand Binding Site [chemical binding]; other site 331678000679 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 331678000680 dimer interface [polypeptide binding]; other site 331678000681 active site 331678000682 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 331678000683 homopentamer interface [polypeptide binding]; other site 331678000684 active site 331678000685 Uncharacterized conserved protein [Function unknown]; Region: COG2128 331678000686 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 331678000687 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 331678000688 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 331678000689 putative acyl-acceptor binding pocket; other site 331678000690 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 331678000691 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 331678000692 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678000693 catalytic residue [active] 331678000694 homoserine kinase; Provisional; Region: PRK01212 331678000695 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 331678000696 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 331678000697 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 331678000698 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 331678000699 beta subunit interaction interface [polypeptide binding]; other site 331678000700 Walker A motif; other site 331678000701 ATP binding site [chemical binding]; other site 331678000702 Walker B motif; other site 331678000703 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 331678000704 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 331678000705 core domain interface [polypeptide binding]; other site 331678000706 delta subunit interface [polypeptide binding]; other site 331678000707 epsilon subunit interface [polypeptide binding]; other site 331678000708 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 331678000709 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 331678000710 putative catalytic residues [active] 331678000711 putative nucleotide binding site [chemical binding]; other site 331678000712 putative aspartate binding site [chemical binding]; other site 331678000713 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 331678000714 dimer interface [polypeptide binding]; other site 331678000715 putative threonine allosteric regulatory site; other site 331678000716 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 331678000717 putative threonine allosteric regulatory site; other site 331678000718 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 331678000719 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 331678000720 competence damage-inducible protein A; Provisional; Region: PRK00549 331678000721 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 331678000722 putative MPT binding site; other site 331678000723 Competence-damaged protein; Region: CinA; pfam02464 331678000724 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 331678000725 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331678000726 ATP binding site [chemical binding]; other site 331678000727 Mg2+ binding site [ion binding]; other site 331678000728 G-X-G motif; other site 331678000729 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 331678000730 ATP binding site [chemical binding]; other site 331678000731 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 331678000732 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 331678000733 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 331678000734 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 331678000735 Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224 331678000736 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 331678000737 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 331678000738 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 331678000739 Ligand binding site; other site 331678000740 Putative Catalytic site; other site 331678000741 DXD motif; other site 331678000742 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 331678000743 elongation factor G; Reviewed; Region: PRK12740 331678000744 G1 box; other site 331678000745 putative GEF interaction site [polypeptide binding]; other site 331678000746 GTP/Mg2+ binding site [chemical binding]; other site 331678000747 Switch I region; other site 331678000748 G2 box; other site 331678000749 G3 box; other site 331678000750 Switch II region; other site 331678000751 G4 box; other site 331678000752 G5 box; other site 331678000753 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 331678000754 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 331678000755 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 331678000756 enolase; Provisional; Region: eno; PRK00077 331678000757 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 331678000758 dimer interface [polypeptide binding]; other site 331678000759 metal binding site [ion binding]; metal-binding site 331678000760 substrate binding pocket [chemical binding]; other site 331678000761 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 331678000762 Septum formation initiator; Region: DivIC; pfam04977 331678000763 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 331678000764 GcpE protein; Region: GcpE; pfam04551 331678000765 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 331678000766 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 331678000767 classical (c) SDRs; Region: SDR_c; cd05233 331678000768 NAD(P) binding site [chemical binding]; other site 331678000769 active site 331678000770 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 331678000771 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 331678000772 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 331678000773 putative homodimer interface [polypeptide binding]; other site 331678000774 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 331678000775 heterodimer interface [polypeptide binding]; other site 331678000776 homodimer interface [polypeptide binding]; other site 331678000777 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 331678000778 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 331678000779 23S rRNA interface [nucleotide binding]; other site 331678000780 L7/L12 interface [polypeptide binding]; other site 331678000781 putative thiostrepton binding site; other site 331678000782 L25 interface [polypeptide binding]; other site 331678000783 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 331678000784 mRNA/rRNA interface [nucleotide binding]; other site 331678000785 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 331678000786 23S rRNA interface [nucleotide binding]; other site 331678000787 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 331678000788 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 331678000789 core dimer interface [polypeptide binding]; other site 331678000790 peripheral dimer interface [polypeptide binding]; other site 331678000791 L10 interface [polypeptide binding]; other site 331678000792 L11 interface [polypeptide binding]; other site 331678000793 putative EF-Tu interaction site [polypeptide binding]; other site 331678000794 putative EF-G interaction site [polypeptide binding]; other site 331678000795 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 331678000796 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 331678000797 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 331678000798 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 331678000799 RPB11 interaction site [polypeptide binding]; other site 331678000800 RPB12 interaction site [polypeptide binding]; other site 331678000801 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 331678000802 RPB3 interaction site [polypeptide binding]; other site 331678000803 RPB1 interaction site [polypeptide binding]; other site 331678000804 RPB11 interaction site [polypeptide binding]; other site 331678000805 RPB10 interaction site [polypeptide binding]; other site 331678000806 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 331678000807 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 331678000808 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 331678000809 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 331678000810 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 331678000811 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 331678000812 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 331678000813 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 331678000814 DNA binding site [nucleotide binding] 331678000815 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 331678000816 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 331678000817 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 331678000818 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 331678000819 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 331678000820 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 331678000821 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 331678000822 carboxyltransferase (CT) interaction site; other site 331678000823 biotinylation site [posttranslational modification]; other site 331678000824 elongation factor P; Validated; Region: PRK00529 331678000825 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 331678000826 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 331678000827 RNA binding site [nucleotide binding]; other site 331678000828 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 331678000829 RNA binding site [nucleotide binding]; other site 331678000830 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 331678000831 IHF - DNA interface [nucleotide binding]; other site 331678000832 IHF dimer interface [polypeptide binding]; other site 331678000833 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 331678000834 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 331678000835 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 331678000836 TPP-binding site [chemical binding]; other site 331678000837 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 331678000838 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 331678000839 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 331678000840 dimer interface [polypeptide binding]; other site 331678000841 PYR/PP interface [polypeptide binding]; other site 331678000842 TPP binding site [chemical binding]; other site 331678000843 substrate binding site [chemical binding]; other site 331678000844 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 331678000845 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 331678000846 motif 1; other site 331678000847 active site 331678000848 motif 2; other site 331678000849 motif 3; other site 331678000850 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 331678000851 Ferredoxin [Energy production and conversion]; Region: COG1146 331678000852 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678000853 NAD(P) binding site [chemical binding]; other site 331678000854 active site 331678000855 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 331678000856 HsdM N-terminal domain; Region: HsdM_N; pfam12161 331678000857 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 331678000858 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 331678000859 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 331678000860 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 331678000861 SIR2-like domain; Region: SIR2_2; pfam13289 331678000862 Piwi_piwi-like_ProArk: PIWI domain, Piwi-like subfamily found in Archaea and Bacteria. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs; Region: Piwi_piwi-like_ProArk; cd04659 331678000863 5' RNA guide strand anchoring site; other site 331678000864 active site 331678000865 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 331678000866 Transposase IS200 like; Region: Y1_Tnp; cl00848 331678000867 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 331678000868 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 331678000869 ATP binding site [chemical binding]; other site 331678000870 putative Mg++ binding site [ion binding]; other site 331678000871 Protein of unknown function DUF45; Region: DUF45; cl00636 331678000872 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 331678000873 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 331678000874 phosphoserine phosphatase SerB; Region: serB; TIGR00338 331678000875 Acid Phosphatase; Region: Acid_PPase; cl17256 331678000876 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331678000877 motif II; other site 331678000878 GMP synthase; Reviewed; Region: guaA; PRK00074 331678000879 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 331678000880 AMP/PPi binding site [chemical binding]; other site 331678000881 candidate oxyanion hole; other site 331678000882 catalytic triad [active] 331678000883 potential glutamine specificity residues [chemical binding]; other site 331678000884 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 331678000885 ATP Binding subdomain [chemical binding]; other site 331678000886 Ligand Binding sites [chemical binding]; other site 331678000887 Dimerization subdomain; other site 331678000888 Transglycosylase; Region: Transgly; pfam00912 331678000889 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 331678000890 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 331678000891 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 331678000892 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 331678000893 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 331678000894 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 331678000895 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 331678000896 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 331678000897 Cytochrome c; Region: Cytochrom_C; cl11414 331678000898 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 331678000899 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 331678000900 putative NAD(P) binding site [chemical binding]; other site 331678000901 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 331678000902 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 331678000903 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 331678000904 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 331678000905 catalytic triad [active] 331678000906 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 331678000907 Clp amino terminal domain; Region: Clp_N; pfam02861 331678000908 Clp amino terminal domain; Region: Clp_N; pfam02861 331678000909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678000910 Walker A motif; other site 331678000911 ATP binding site [chemical binding]; other site 331678000912 Walker B motif; other site 331678000913 arginine finger; other site 331678000914 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678000915 Walker A motif; other site 331678000916 ATP binding site [chemical binding]; other site 331678000917 Walker B motif; other site 331678000918 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 331678000919 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 331678000920 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 331678000921 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678000922 catalytic residue [active] 331678000923 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 331678000924 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 331678000925 putative active site [active] 331678000926 thiamine monophosphate kinase; Provisional; Region: PRK05731 331678000927 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 331678000928 ATP binding site [chemical binding]; other site 331678000929 dimerization interface [polypeptide binding]; other site 331678000930 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 331678000931 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 331678000932 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 331678000933 GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441 331678000934 GIY-YIG motif/motif A; other site 331678000935 putative active site [active] 331678000936 putative metal binding site [ion binding]; other site 331678000937 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 331678000938 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 331678000939 S-adenosylmethionine binding site [chemical binding]; other site 331678000940 SurA N-terminal domain; Region: SurA_N_3; cl07813 331678000941 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 331678000942 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 331678000943 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 331678000944 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 331678000945 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 331678000946 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 331678000947 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 331678000948 replicative DNA helicase; Region: DnaB; TIGR00665 331678000949 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 331678000950 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 331678000951 Walker A motif; other site 331678000952 ATP binding site [chemical binding]; other site 331678000953 Walker B motif; other site 331678000954 DNA binding loops [nucleotide binding] 331678000955 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 331678000956 Fe-S cluster binding site [ion binding]; other site 331678000957 active site 331678000958 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 331678000959 Flavoprotein; Region: Flavoprotein; pfam02441 331678000960 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 331678000961 Family of unknown function (DUF490); Region: DUF490; pfam04357 331678000962 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 331678000963 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 331678000964 active site 331678000965 nucleotide binding site [chemical binding]; other site 331678000966 HIGH motif; other site 331678000967 KMSKS motif; other site 331678000968 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 331678000969 putative acyl-acceptor binding pocket; other site 331678000970 Chain length determinant protein; Region: Wzz; cl15801 331678000971 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 331678000972 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 331678000973 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 331678000974 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 331678000975 NAD(P) binding site [chemical binding]; other site 331678000976 homodimer interface [polypeptide binding]; other site 331678000977 substrate binding site [chemical binding]; other site 331678000978 active site 331678000979 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678000980 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 331678000981 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331678000982 Walker A/P-loop; other site 331678000983 ATP binding site [chemical binding]; other site 331678000984 Q-loop/lid; other site 331678000985 ABC transporter signature motif; other site 331678000986 Walker B; other site 331678000987 D-loop; other site 331678000988 H-loop/switch region; other site 331678000989 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 331678000990 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 331678000991 putative ADP-binding pocket [chemical binding]; other site 331678000992 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 331678000993 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 331678000994 putative active site [active] 331678000995 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 331678000996 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 331678000997 active site 331678000998 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 331678000999 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 331678001000 putative ADP-binding pocket [chemical binding]; other site 331678001001 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 331678001002 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 331678001003 putative ADP-binding pocket [chemical binding]; other site 331678001004 Bacterial sugar transferase; Region: Bac_transf; pfam02397 331678001005 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 331678001006 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 331678001007 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 331678001008 extended (e) SDRs; Region: SDR_e; cd08946 331678001009 NAD(P) binding site [chemical binding]; other site 331678001010 active site 331678001011 substrate binding site [chemical binding]; other site 331678001012 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 331678001013 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 331678001014 inhibitor-cofactor binding pocket; inhibition site 331678001015 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678001016 catalytic residue [active] 331678001017 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 331678001018 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 331678001019 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 331678001020 Walker A/P-loop; other site 331678001021 ATP binding site [chemical binding]; other site 331678001022 Q-loop/lid; other site 331678001023 ABC transporter signature motif; other site 331678001024 Walker B; other site 331678001025 D-loop; other site 331678001026 H-loop/switch region; other site 331678001027 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 331678001028 Substrate binding site; other site 331678001029 metal-binding site 331678001030 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 331678001031 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 331678001032 putative metal binding site; other site 331678001033 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 331678001034 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 331678001035 putative active site [active] 331678001036 O-Antigen ligase; Region: Wzy_C; pfam04932 331678001037 CAAX protease self-immunity; Region: Abi; pfam02517 331678001038 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 331678001039 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 331678001040 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 331678001041 active site 331678001042 phosphorylation site [posttranslational modification] 331678001043 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 331678001044 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 331678001045 dimer interface [polypeptide binding]; other site 331678001046 motif 1; other site 331678001047 active site 331678001048 motif 2; other site 331678001049 motif 3; other site 331678001050 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 331678001051 anticodon binding site; other site 331678001052 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 331678001053 ribosome maturation protein RimP; Reviewed; Region: PRK00092 331678001054 hypothetical protein; Provisional; Region: PRK14641 331678001055 NusA N-terminal domain; Region: NusA_N; pfam08529 331678001056 transcription termination factor NusA; Region: NusA; TIGR01953 331678001057 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 331678001058 RNA binding site [nucleotide binding]; other site 331678001059 homodimer interface [polypeptide binding]; other site 331678001060 NusA-like KH domain; Region: KH_5; pfam13184 331678001061 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 331678001062 G-X-X-G motif; other site 331678001063 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 331678001064 translation initiation factor IF-2; Region: IF-2; TIGR00487 331678001065 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 331678001066 G1 box; other site 331678001067 putative GEF interaction site [polypeptide binding]; other site 331678001068 GTP/Mg2+ binding site [chemical binding]; other site 331678001069 Switch I region; other site 331678001070 G2 box; other site 331678001071 G3 box; other site 331678001072 Switch II region; other site 331678001073 G4 box; other site 331678001074 G5 box; other site 331678001075 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 331678001076 Translation-initiation factor 2; Region: IF-2; pfam11987 331678001077 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 331678001078 Ribosome-binding factor A; Region: RBFA; pfam02033 331678001079 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 331678001080 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 331678001081 RNA binding site [nucleotide binding]; other site 331678001082 active site 331678001083 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 331678001084 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 331678001085 active site 331678001086 Riboflavin kinase; Region: Flavokinase; pfam01687 331678001087 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 331678001088 16S/18S rRNA binding site [nucleotide binding]; other site 331678001089 S13e-L30e interaction site [polypeptide binding]; other site 331678001090 25S rRNA binding site [nucleotide binding]; other site 331678001091 hypothetical protein; Provisional; Region: PRK11820 331678001092 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 331678001093 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 331678001094 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 331678001095 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 331678001096 catalytic site [active] 331678001097 G-X2-G-X-G-K; other site 331678001098 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 331678001099 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 331678001100 active site 331678001101 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 331678001102 Substrate binding site; other site 331678001103 Mg++ binding site; other site 331678001104 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 331678001105 tetramerization interface [polypeptide binding]; other site 331678001106 active site 331678001107 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 331678001108 periplasmic chaperone; Provisional; Region: PRK10780 331678001109 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 331678001110 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 331678001111 DNA protecting protein DprA; Region: dprA; TIGR00732 331678001112 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 331678001113 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 331678001114 substrate binding pocket [chemical binding]; other site 331678001115 chain length determination region; other site 331678001116 substrate-Mg2+ binding site; other site 331678001117 catalytic residues [active] 331678001118 aspartate-rich region 1; other site 331678001119 active site lid residues [active] 331678001120 aspartate-rich region 2; other site 331678001121 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 331678001122 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 331678001123 homotetramer interface [polypeptide binding]; other site 331678001124 FMN binding site [chemical binding]; other site 331678001125 homodimer contacts [polypeptide binding]; other site 331678001126 putative active site [active] 331678001127 putative substrate binding site [chemical binding]; other site 331678001128 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 331678001129 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 331678001130 FtsX-like permease family; Region: FtsX; pfam02687 331678001131 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 331678001132 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 331678001133 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 331678001134 Walker A/P-loop; other site 331678001135 ATP binding site [chemical binding]; other site 331678001136 Q-loop/lid; other site 331678001137 ABC transporter signature motif; other site 331678001138 Walker B; other site 331678001139 D-loop; other site 331678001140 H-loop/switch region; other site 331678001141 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 331678001142 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 331678001143 active site 331678001144 substrate binding site [chemical binding]; other site 331678001145 metal binding site [ion binding]; metal-binding site 331678001146 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 331678001147 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 331678001148 RuvA N terminal domain; Region: RuvA_N; pfam01330 331678001149 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 331678001150 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 331678001151 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 331678001152 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 331678001153 transcription termination factor Rho; Provisional; Region: rho; PRK09376 331678001154 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 331678001155 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 331678001156 RNA binding site [nucleotide binding]; other site 331678001157 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 331678001158 multimer interface [polypeptide binding]; other site 331678001159 Walker A motif; other site 331678001160 ATP binding site [chemical binding]; other site 331678001161 Walker B motif; other site 331678001162 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 331678001163 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 331678001164 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 331678001165 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 331678001166 Ligand binding site [chemical binding]; other site 331678001167 Electron transfer flavoprotein domain; Region: ETF; pfam01012 331678001168 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 331678001169 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 331678001170 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 331678001171 Bifunctional nuclease; Region: DNase-RNase; pfam02577 331678001172 UvrB/uvrC motif; Region: UVR; pfam02151 331678001173 Surface antigen; Region: Surface_Ag_2; pfam01617 331678001174 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 331678001175 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 331678001176 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 331678001177 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 331678001178 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 331678001179 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 331678001180 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 331678001181 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 331678001182 Surface antigen; Region: Bac_surface_Ag; pfam01103 331678001183 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 331678001184 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 331678001185 catalytic residue [active] 331678001186 putative FPP diphosphate binding site; other site 331678001187 putative FPP binding hydrophobic cleft; other site 331678001188 dimer interface [polypeptide binding]; other site 331678001189 putative IPP diphosphate binding site; other site 331678001190 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 331678001191 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 331678001192 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 331678001193 CoA binding domain; Region: CoA_binding; smart00881 331678001194 CoA-ligase; Region: Ligase_CoA; pfam00549 331678001195 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 331678001196 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 331678001197 putative active site [active] 331678001198 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 331678001199 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 331678001200 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 331678001201 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 331678001202 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 331678001203 Heavy-metal resistance; Region: Metal_resist; pfam13801 331678001204 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 331678001205 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 331678001206 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 331678001207 DNA binding residues [nucleotide binding] 331678001208 Methyltransferase domain; Region: Methyltransf_31; pfam13847 331678001209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678001210 S-adenosylmethionine binding site [chemical binding]; other site 331678001211 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 331678001212 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 331678001213 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 331678001214 active site 331678001215 substrate binding site [chemical binding]; other site 331678001216 metal binding site [ion binding]; metal-binding site 331678001217 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 331678001218 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 331678001219 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 331678001220 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 331678001221 TOBE domain; Region: TOBE; cl01440 331678001222 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 331678001223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331678001224 dimer interface [polypeptide binding]; other site 331678001225 conserved gate region; other site 331678001226 putative PBP binding loops; other site 331678001227 ABC-ATPase subunit interface; other site 331678001228 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 331678001229 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331678001230 Walker A/P-loop; other site 331678001231 ATP binding site [chemical binding]; other site 331678001232 Q-loop/lid; other site 331678001233 ABC transporter signature motif; other site 331678001234 Walker B; other site 331678001235 D-loop; other site 331678001236 H-loop/switch region; other site 331678001237 putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814 331678001238 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 331678001239 catalytic loop [active] 331678001240 iron binding site [ion binding]; other site 331678001241 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 331678001242 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 331678001243 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 331678001244 LytB protein; Region: LYTB; cl00507 331678001245 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 331678001246 pteridine reductase; Provisional; Region: PRK09135 331678001247 classical (c) SDRs; Region: SDR_c; cd05233 331678001248 NAD(P) binding site [chemical binding]; other site 331678001249 active site 331678001250 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 331678001251 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 331678001252 Walker A/P-loop; other site 331678001253 ATP binding site [chemical binding]; other site 331678001254 Q-loop/lid; other site 331678001255 ABC transporter signature motif; other site 331678001256 Walker B; other site 331678001257 D-loop; other site 331678001258 H-loop/switch region; other site 331678001259 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 331678001260 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 331678001261 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 331678001262 nucleotide binding pocket [chemical binding]; other site 331678001263 K-X-D-G motif; other site 331678001264 catalytic site [active] 331678001265 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 331678001266 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 331678001267 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 331678001268 Dimer interface [polypeptide binding]; other site 331678001269 BRCT sequence motif; other site 331678001270 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 331678001271 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 331678001272 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678001273 S-adenosylmethionine binding site [chemical binding]; other site 331678001274 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 331678001275 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 331678001276 HlyD family secretion protein; Region: HlyD_3; pfam13437 331678001277 Membrane transport protein; Region: Mem_trans; cl09117 331678001278 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 331678001279 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 331678001280 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 331678001281 putative dimer interface [polypeptide binding]; other site 331678001282 [2Fe-2S] cluster binding site [ion binding]; other site 331678001283 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 331678001284 dimer interface [polypeptide binding]; other site 331678001285 [2Fe-2S] cluster binding site [ion binding]; other site 331678001286 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 331678001287 SLBB domain; Region: SLBB; pfam10531 331678001288 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 331678001289 4Fe-4S binding domain; Region: Fer4; pfam00037 331678001290 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 331678001291 4Fe-4S binding domain; Region: Fer4; pfam00037 331678001292 putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814 331678001293 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 331678001294 catalytic loop [active] 331678001295 iron binding site [ion binding]; other site 331678001296 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 331678001297 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331678001298 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 331678001299 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 331678001300 molybdopterin cofactor binding site; other site 331678001301 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 331678001302 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 331678001303 putative active site [active] 331678001304 oxyanion strand; other site 331678001305 catalytic triad [active] 331678001306 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 331678001307 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 331678001308 catalytic residues [active] 331678001309 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 331678001310 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 331678001311 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 331678001312 RNA binding surface [nucleotide binding]; other site 331678001313 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 331678001314 active site 331678001315 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 331678001316 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 331678001317 active site 331678001318 substrate binding site [chemical binding]; other site 331678001319 catalytic site [active] 331678001320 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 331678001321 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 331678001322 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331678001323 motif II; other site 331678001324 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 331678001325 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 331678001326 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 331678001327 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 331678001328 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 331678001329 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 331678001330 aminodeoxychorismate synthase; Provisional; Region: PRK07508 331678001331 chorismate binding enzyme; Region: Chorismate_bind; cl10555 331678001332 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 331678001333 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 331678001334 homodimer interface [polypeptide binding]; other site 331678001335 substrate-cofactor binding pocket; other site 331678001336 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678001337 catalytic residue [active] 331678001338 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 331678001339 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 331678001340 minor groove reading motif; other site 331678001341 helix-hairpin-helix signature motif; other site 331678001342 substrate binding pocket [chemical binding]; other site 331678001343 active site 331678001344 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 331678001345 Transposase domain (DUF772); Region: DUF772; pfam05598 331678001346 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 331678001347 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 331678001348 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 331678001349 active site 331678001350 metal binding site [ion binding]; metal-binding site 331678001351 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 331678001352 putative RNA binding site [nucleotide binding]; other site 331678001353 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 331678001354 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331678001355 motif II; other site 331678001356 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 331678001357 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 331678001358 Walker A/P-loop; other site 331678001359 ATP binding site [chemical binding]; other site 331678001360 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 331678001361 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 331678001362 ABC transporter signature motif; other site 331678001363 Walker B; other site 331678001364 D-loop; other site 331678001365 H-loop/switch region; other site 331678001366 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 331678001367 dihydropteroate synthase; Region: DHPS; TIGR01496 331678001368 substrate binding pocket [chemical binding]; other site 331678001369 dimer interface [polypeptide binding]; other site 331678001370 inhibitor binding site; inhibition site 331678001371 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 331678001372 Peptidase family M50; Region: Peptidase_M50; pfam02163 331678001373 active site 331678001374 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 331678001375 putative substrate binding region [chemical binding]; other site 331678001376 Haem-binding domain; Region: Haem_bd; pfam14376 331678001377 Methyltransferase domain; Region: Methyltransf_25; pfam13649 331678001378 Rrf2 family protein; Region: rrf2_super; TIGR00738 331678001379 Transcriptional regulator; Region: Rrf2; pfam02082 331678001380 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678001381 TPR motif; other site 331678001382 TPR repeat; Region: TPR_11; pfam13414 331678001383 binding surface 331678001384 hybrid cluster protein; Provisional; Region: PRK05290 331678001385 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 331678001386 ACS interaction site; other site 331678001387 CODH interaction site; other site 331678001388 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 331678001389 hybrid metal cluster; other site 331678001390 Predicted permeases [General function prediction only]; Region: COG0701 331678001391 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 331678001392 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331678001393 putative DNA binding site [nucleotide binding]; other site 331678001394 dimerization interface [polypeptide binding]; other site 331678001395 putative Zn2+ binding site [ion binding]; other site 331678001396 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 331678001397 ZIP Zinc transporter; Region: Zip; pfam02535 331678001398 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 331678001399 dimer interface [polypeptide binding]; other site 331678001400 Alkaline phosphatase homologues; Region: alkPPc; smart00098 331678001401 active site 331678001402 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 331678001403 YibE/F-like protein; Region: YibE_F; pfam07907 331678001404 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 331678001405 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 331678001406 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 331678001407 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 331678001408 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678001409 FeS/SAM binding site; other site 331678001410 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 331678001411 A new structural DNA glycosylase; Region: AlkD_like; cd06561 331678001412 active site 331678001413 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331678001414 dimerization interface [polypeptide binding]; other site 331678001415 putative DNA binding site [nucleotide binding]; other site 331678001416 putative Zn2+ binding site [ion binding]; other site 331678001417 Predicted permeases [General function prediction only]; Region: COG0701 331678001418 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782 331678001419 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 331678001420 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331678001421 motif II; other site 331678001422 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 331678001423 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 331678001424 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 331678001425 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 331678001426 pyruvate phosphate dikinase; Provisional; Region: PRK09279 331678001427 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 331678001428 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 331678001429 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 331678001430 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 331678001431 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 331678001432 TM-ABC transporter signature motif; other site 331678001433 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 331678001434 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 331678001435 conserved cys residue [active] 331678001436 NAD-dependent deacetylase; Provisional; Region: PRK00481 331678001437 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 331678001438 NAD+ binding site [chemical binding]; other site 331678001439 substrate binding site [chemical binding]; other site 331678001440 Zn binding site [ion binding]; other site 331678001441 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 331678001442 Isochorismatase family; Region: Isochorismatase; pfam00857 331678001443 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 331678001444 catalytic triad [active] 331678001445 dimer interface [polypeptide binding]; other site 331678001446 conserved cis-peptide bond; other site 331678001447 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 331678001448 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 331678001449 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 331678001450 putative acyl-acceptor binding pocket; other site 331678001451 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 331678001452 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 331678001453 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 331678001454 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 331678001455 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 331678001456 MPN+ (JAMM) motif; other site 331678001457 Zinc-binding site [ion binding]; other site 331678001458 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 331678001459 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 331678001460 ATP-grasp domain; Region: ATP-grasp_4; cl17255 331678001461 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 331678001462 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 331678001463 active site 331678001464 ribulose/triose binding site [chemical binding]; other site 331678001465 phosphate binding site [ion binding]; other site 331678001466 substrate (anthranilate) binding pocket [chemical binding]; other site 331678001467 product (indole) binding pocket [chemical binding]; other site 331678001468 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 331678001469 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 331678001470 substrate binding site [chemical binding]; other site 331678001471 hexamer interface [polypeptide binding]; other site 331678001472 metal binding site [ion binding]; metal-binding site 331678001473 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 331678001474 Surface antigen; Region: Bac_surface_Ag; pfam01103 331678001475 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 331678001476 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 331678001477 Peptidase family M23; Region: Peptidase_M23; pfam01551 331678001478 DNA polymerase I; Provisional; Region: PRK05755 331678001479 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 331678001480 active site 331678001481 metal binding site 1 [ion binding]; metal-binding site 331678001482 putative 5' ssDNA interaction site; other site 331678001483 metal binding site 3; metal-binding site 331678001484 metal binding site 2 [ion binding]; metal-binding site 331678001485 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 331678001486 putative DNA binding site [nucleotide binding]; other site 331678001487 putative metal binding site [ion binding]; other site 331678001488 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 331678001489 active site 331678001490 catalytic site [active] 331678001491 substrate binding site [chemical binding]; other site 331678001492 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 331678001493 active site 331678001494 DNA binding site [nucleotide binding] 331678001495 catalytic site [active] 331678001496 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 331678001497 Prephenate dehydratase; Region: PDT; pfam00800 331678001498 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 331678001499 putative L-Phe binding site [chemical binding]; other site 331678001500 hypothetical protein; Validated; Region: PRK00110 331678001501 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 331678001502 active site 331678001503 putative DNA-binding cleft [nucleotide binding]; other site 331678001504 dimer interface [polypeptide binding]; other site 331678001505 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 331678001506 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 331678001507 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 331678001508 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 331678001509 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 331678001510 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 331678001511 active site 331678001512 dimerization interface [polypeptide binding]; other site 331678001513 TspO/MBR family; Region: TspO_MBR; pfam03073 331678001514 acetyl-CoA synthetase; Provisional; Region: PRK00174 331678001515 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 331678001516 active site 331678001517 CoA binding site [chemical binding]; other site 331678001518 acyl-activating enzyme (AAE) consensus motif; other site 331678001519 AMP binding site [chemical binding]; other site 331678001520 acetate binding site [chemical binding]; other site 331678001521 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 331678001522 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 331678001523 HIGH motif; other site 331678001524 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 331678001525 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 331678001526 active site 331678001527 KMSKS motif; other site 331678001528 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 331678001529 tRNA binding surface [nucleotide binding]; other site 331678001530 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 331678001531 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 331678001532 RNase E interface [polypeptide binding]; other site 331678001533 trimer interface [polypeptide binding]; other site 331678001534 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 331678001535 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 331678001536 RNase E interface [polypeptide binding]; other site 331678001537 trimer interface [polypeptide binding]; other site 331678001538 active site 331678001539 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 331678001540 putative nucleic acid binding region [nucleotide binding]; other site 331678001541 G-X-X-G motif; other site 331678001542 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 331678001543 RNA binding site [nucleotide binding]; other site 331678001544 domain interface; other site 331678001545 pantoate--beta-alanine ligase; Region: panC; TIGR00018 331678001546 Pantoate-beta-alanine ligase; Region: PanC; cd00560 331678001547 active site 331678001548 ATP-binding site [chemical binding]; other site 331678001549 pantoate-binding site; other site 331678001550 HXXH motif; other site 331678001551 Predicted methyltransferases [General function prediction only]; Region: COG0313 331678001552 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 331678001553 putative SAM binding site [chemical binding]; other site 331678001554 putative homodimer interface [polypeptide binding]; other site 331678001555 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 331678001556 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 331678001557 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331678001558 non-specific DNA binding site [nucleotide binding]; other site 331678001559 salt bridge; other site 331678001560 sequence-specific DNA binding site [nucleotide binding]; other site 331678001561 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 331678001562 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 331678001563 Walker A/P-loop; other site 331678001564 ATP binding site [chemical binding]; other site 331678001565 Q-loop/lid; other site 331678001566 ABC transporter signature motif; other site 331678001567 Walker B; other site 331678001568 D-loop; other site 331678001569 H-loop/switch region; other site 331678001570 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 331678001571 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 331678001572 tandem repeat interface [polypeptide binding]; other site 331678001573 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 331678001574 oligomer interface [polypeptide binding]; other site 331678001575 active site residues [active] 331678001576 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 331678001577 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 331678001578 tandem repeat interface [polypeptide binding]; other site 331678001579 oligomer interface [polypeptide binding]; other site 331678001580 active site residues [active] 331678001581 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 331678001582 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 331678001583 active site 331678001584 cosubstrate binding site; other site 331678001585 substrate binding site [chemical binding]; other site 331678001586 catalytic site [active] 331678001587 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 331678001588 Sodium Bile acid symporter family; Region: SBF; cl17470 331678001589 Low molecular weight phosphatase family; Region: LMWPc; cl00105 331678001590 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 331678001591 active site 331678001592 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331678001593 dimerization interface [polypeptide binding]; other site 331678001594 putative DNA binding site [nucleotide binding]; other site 331678001595 putative Zn2+ binding site [ion binding]; other site 331678001596 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 331678001597 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331678001598 non-specific DNA binding site [nucleotide binding]; other site 331678001599 salt bridge; other site 331678001600 sequence-specific DNA binding site [nucleotide binding]; other site 331678001601 Transposase [DNA replication, recombination, and repair]; Region: COG5421 331678001602 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 331678001603 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 331678001604 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 331678001605 Photosystem P840 reaction-centre cytochrome c-551; Region: Cytochrome-c551; pfam10643 331678001606 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 331678001607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678001608 S-adenosylmethionine binding site [chemical binding]; other site 331678001609 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 331678001610 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 331678001611 active site 331678001612 DNA binding site [nucleotide binding] 331678001613 Int/Topo IB signature motif; other site 331678001614 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 331678001615 30S subunit binding site; other site 331678001616 HPr kinase/phosphorylase; Provisional; Region: PRK05428 331678001617 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 331678001618 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 331678001619 Hpr binding site; other site 331678001620 active site 331678001621 homohexamer subunit interaction site [polypeptide binding]; other site 331678001622 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 331678001623 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 331678001624 peptide binding site [polypeptide binding]; other site 331678001625 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 331678001626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331678001627 dimer interface [polypeptide binding]; other site 331678001628 conserved gate region; other site 331678001629 putative PBP binding loops; other site 331678001630 ABC-ATPase subunit interface; other site 331678001631 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 331678001632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678001633 Walker A motif; other site 331678001634 ATP binding site [chemical binding]; other site 331678001635 Walker B motif; other site 331678001636 arginine finger; other site 331678001637 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 331678001638 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 331678001639 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678001640 TPR motif; other site 331678001641 binding surface 331678001642 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678001643 TPR motif; other site 331678001644 binding surface 331678001645 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678001646 TPR motif; other site 331678001647 binding surface 331678001648 TPR repeat; Region: TPR_11; pfam13414 331678001649 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678001650 TPR motif; other site 331678001651 Tetratricopeptide repeat; Region: TPR_12; pfam13424 331678001652 binding surface 331678001653 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 331678001654 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 331678001655 dimer interface [polypeptide binding]; other site 331678001656 PYR/PP interface [polypeptide binding]; other site 331678001657 TPP binding site [chemical binding]; other site 331678001658 substrate binding site [chemical binding]; other site 331678001659 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 331678001660 Domain of unknown function; Region: EKR; pfam10371 331678001661 4Fe-4S binding domain; Region: Fer4_6; pfam12837 331678001662 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 331678001663 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 331678001664 TPP-binding site [chemical binding]; other site 331678001665 dimer interface [polypeptide binding]; other site 331678001666 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 331678001667 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 331678001668 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 331678001669 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 331678001670 lipoyl attachment site [posttranslational modification]; other site 331678001671 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 331678001672 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 331678001673 tetramer interface [polypeptide binding]; other site 331678001674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678001675 catalytic residue [active] 331678001676 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 331678001677 dihydrodipicolinate synthase; Region: dapA; TIGR00674 331678001678 dimer interface [polypeptide binding]; other site 331678001679 active site 331678001680 catalytic residue [active] 331678001681 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 331678001682 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 331678001683 Walker A/P-loop; other site 331678001684 ATP binding site [chemical binding]; other site 331678001685 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 331678001686 Q-loop/lid; other site 331678001687 ABC transporter signature motif; other site 331678001688 Walker B; other site 331678001689 D-loop; other site 331678001690 H-loop/switch region; other site 331678001691 Lamin Tail Domain; Region: LTD; pfam00932 331678001692 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 331678001693 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 331678001694 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 331678001695 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 331678001696 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 331678001697 Ligand Binding Site [chemical binding]; other site 331678001698 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 331678001699 RNA/DNA hybrid binding site [nucleotide binding]; other site 331678001700 active site 331678001701 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 331678001702 bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566 331678001703 UbiA prenyltransferase family; Region: UbiA; pfam01040 331678001704 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 331678001705 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 331678001706 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 331678001707 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 331678001708 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 331678001709 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 331678001710 active site 331678001711 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 331678001712 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 331678001713 DNA polymerase III subunit delta'; Validated; Region: PRK07132 331678001714 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 331678001715 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 331678001716 homodimer interface [polypeptide binding]; other site 331678001717 substrate-cofactor binding pocket; other site 331678001718 catalytic residue [active] 331678001719 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 331678001720 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 331678001721 active site 331678001722 ADP/pyrophosphate binding site [chemical binding]; other site 331678001723 dimerization interface [polypeptide binding]; other site 331678001724 allosteric effector site; other site 331678001725 fructose-1,6-bisphosphate binding site; other site 331678001726 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 331678001727 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 331678001728 FtsX-like permease family; Region: FtsX; pfam02687 331678001729 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 331678001730 homotrimer interaction site [polypeptide binding]; other site 331678001731 zinc binding site [ion binding]; other site 331678001732 CDP-binding sites; other site 331678001733 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 331678001734 Protein of unknown function (DUF805); Region: DUF805; pfam05656 331678001735 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 331678001736 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 331678001737 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 331678001738 heterodimer interface [polypeptide binding]; other site 331678001739 active site 331678001740 FMN binding site [chemical binding]; other site 331678001741 homodimer interface [polypeptide binding]; other site 331678001742 substrate binding site [chemical binding]; other site 331678001743 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 331678001744 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 331678001745 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 331678001746 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 331678001747 putative active site [active] 331678001748 putative metal binding site [ion binding]; other site 331678001749 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 331678001750 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 331678001751 Ferritin-like domain; Region: Ferritin; pfam00210 331678001752 ferroxidase diiron center [ion binding]; other site 331678001753 FeoA domain; Region: FeoA; pfam04023 331678001754 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 331678001755 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 331678001756 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 331678001757 G1 box; other site 331678001758 GTP/Mg2+ binding site [chemical binding]; other site 331678001759 Switch I region; other site 331678001760 G2 box; other site 331678001761 G3 box; other site 331678001762 Switch II region; other site 331678001763 G4 box; other site 331678001764 G5 box; other site 331678001765 Nucleoside recognition; Region: Gate; pfam07670 331678001766 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 331678001767 Nucleoside recognition; Region: Gate; pfam07670 331678001768 FeoC like transcriptional regulator; Region: FeoC; pfam09012 331678001769 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 331678001770 iron-sulfur cluster [ion binding]; other site 331678001771 [2Fe-2S] cluster binding site [ion binding]; other site 331678001772 Putative molybdenum carrier; Region: MoCo_carrier; pfam12694 331678001773 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 331678001774 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 331678001775 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 331678001776 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 331678001777 ATP-grasp domain; Region: ATP-grasp_4; cl17255 331678001778 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 331678001779 IMP binding site; other site 331678001780 dimer interface [polypeptide binding]; other site 331678001781 interdomain contacts; other site 331678001782 partial ornithine binding site; other site 331678001783 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 331678001784 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 331678001785 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 331678001786 dimerization interface [polypeptide binding]; other site 331678001787 active site 331678001788 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 331678001789 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 331678001790 dimer interface [polypeptide binding]; other site 331678001791 active site 331678001792 glycine-pyridoxal phosphate binding site [chemical binding]; other site 331678001793 folate binding site [chemical binding]; other site 331678001794 DNA primase; Validated; Region: dnaG; PRK05667 331678001795 CHC2 zinc finger; Region: zf-CHC2; pfam01807 331678001796 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 331678001797 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 331678001798 active site 331678001799 metal binding site [ion binding]; metal-binding site 331678001800 interdomain interaction site; other site 331678001801 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 331678001802 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 331678001803 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 331678001804 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 331678001805 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 331678001806 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 331678001807 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 331678001808 acetylornithine aminotransferase; Provisional; Region: PRK02627 331678001809 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 331678001810 inhibitor-cofactor binding pocket; inhibition site 331678001811 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678001812 catalytic residue [active] 331678001813 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 331678001814 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 331678001815 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331678001816 Predicted transcriptional regulator [Transcription]; Region: COG1959 331678001817 Transcriptional regulator; Region: Rrf2; pfam02082 331678001818 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 331678001819 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 331678001820 dimer interface [polypeptide binding]; other site 331678001821 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678001822 catalytic residue [active] 331678001823 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 331678001824 thiS-thiF/thiG interaction site; other site 331678001825 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 331678001826 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 331678001827 homodimer interface [polypeptide binding]; other site 331678001828 substrate-cofactor binding pocket; other site 331678001829 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678001830 catalytic residue [active] 331678001831 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 331678001832 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 331678001833 ATP binding site [chemical binding]; other site 331678001834 substrate interface [chemical binding]; other site 331678001835 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 331678001836 MPN+ (JAMM) motif; other site 331678001837 Zinc-binding site [ion binding]; other site 331678001838 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 331678001839 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 331678001840 CPxP motif; other site 331678001841 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678001842 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 331678001843 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 331678001844 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 331678001845 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 331678001846 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 331678001847 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 331678001848 ResB-like family; Region: ResB; pfam05140 331678001849 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 331678001850 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 331678001851 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 331678001852 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 331678001853 N-terminal plug; other site 331678001854 ligand-binding site [chemical binding]; other site 331678001855 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 331678001856 AIR carboxylase; Region: AIRC; pfam00731 331678001857 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 331678001858 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678001859 FeS/SAM binding site; other site 331678001860 HemN C-terminal domain; Region: HemN_C; pfam06969 331678001861 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 331678001862 active site 331678001863 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 331678001864 FMN binding site [chemical binding]; other site 331678001865 dimer interface [polypeptide binding]; other site 331678001866 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 331678001867 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 331678001868 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 331678001869 ABC transporter; Region: ABC_tran_2; pfam12848 331678001870 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 331678001871 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 331678001872 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 331678001873 Transposase domain (DUF772); Region: DUF772; pfam05598 331678001874 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 331678001875 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 331678001876 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 331678001877 glutathione synthetase; Provisional; Region: PRK12458 331678001878 ATP-grasp domain; Region: ATP-grasp_4; cl17255 331678001879 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 331678001880 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 331678001881 CoA-ligase; Region: Ligase_CoA; pfam00549 331678001882 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 331678001883 nucleoside/Zn binding site; other site 331678001884 dimer interface [polypeptide binding]; other site 331678001885 catalytic motif [active] 331678001886 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 331678001887 FMN binding site [chemical binding]; other site 331678001888 substrate binding site [chemical binding]; other site 331678001889 putative catalytic residue [active] 331678001890 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 331678001891 catalytic core [active] 331678001892 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 331678001893 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 331678001894 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 331678001895 active site 331678001896 dimer interface [polypeptide binding]; other site 331678001897 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 331678001898 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 331678001899 active site 331678001900 FMN binding site [chemical binding]; other site 331678001901 substrate binding site [chemical binding]; other site 331678001902 3Fe-4S cluster binding site [ion binding]; other site 331678001903 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 331678001904 domain interface; other site 331678001905 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 331678001906 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 331678001907 Domain of unknown function (DUF4404); Region: DUF4404; pfam14357 331678001908 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 331678001909 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 331678001910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678001911 Walker A motif; other site 331678001912 ATP binding site [chemical binding]; other site 331678001913 Walker B motif; other site 331678001914 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 331678001915 Protein of unknown function (DUF3946); Region: DUF3946; pfam13102 331678001916 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 331678001917 active site 331678001918 DNA binding site [nucleotide binding] 331678001919 Int/Topo IB signature motif; other site 331678001920 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 331678001921 nif11-like peptide radical SAM maturase; Region: rSAM_nif11; TIGR04064 331678001922 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678001923 FeS/SAM binding site; other site 331678001924 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 331678001925 Helix-turn-helix domain; Region: HTH_17; pfam12728 331678001926 ParA-like protein; Provisional; Region: PHA02518 331678001927 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 331678001928 P-loop; other site 331678001929 Magnesium ion binding site [ion binding]; other site 331678001930 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 331678001931 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 331678001932 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 331678001933 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 331678001934 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 331678001935 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 331678001936 Walker A motif; other site 331678001937 ATP binding site [chemical binding]; other site 331678001938 Walker B motif; other site 331678001939 Type II/IV secretion system protein; Region: T2SE; pfam00437 331678001940 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 331678001941 ATP binding site [chemical binding]; other site 331678001942 Walker A motif; other site 331678001943 hexamer interface [polypeptide binding]; other site 331678001944 Walker B motif; other site 331678001945 Helix-turn-helix domain; Region: HTH_17; pfam12728 331678001946 Helix-turn-helix domain; Region: HTH_19; pfam12844 331678001947 active site 331678001948 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 331678001949 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331678001950 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 331678001951 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 331678001952 TM-ABC transporter signature motif; other site 331678001953 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 331678001954 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 331678001955 TM-ABC transporter signature motif; other site 331678001956 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 331678001957 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331678001958 Walker A/P-loop; other site 331678001959 ATP binding site [chemical binding]; other site 331678001960 Q-loop/lid; other site 331678001961 ABC transporter signature motif; other site 331678001962 Walker B; other site 331678001963 D-loop; other site 331678001964 H-loop/switch region; other site 331678001965 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 331678001966 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331678001967 Walker A/P-loop; other site 331678001968 ATP binding site [chemical binding]; other site 331678001969 Q-loop/lid; other site 331678001970 ABC transporter signature motif; other site 331678001971 Walker B; other site 331678001972 D-loop; other site 331678001973 H-loop/switch region; other site 331678001974 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 331678001975 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 331678001976 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678001977 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678001978 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 331678001979 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 331678001980 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 331678001981 DEAD-like helicases superfamily; Region: DEXDc; smart00487 331678001982 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 331678001983 Domain of unknown function DUF87; Region: DUF87; pfam01935 331678001984 HerA helicase [Replication, recombination, and repair]; Region: COG0433 331678001985 Transposase domain (DUF772); Region: DUF772; pfam05598 331678001986 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 331678001987 DDE superfamily endonuclease; Region: DDE_4; cl17710 331678001988 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 331678001989 Predicted transcriptional regulator [Transcription]; Region: COG5340 331678001990 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 331678001991 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 331678001992 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 331678001993 Fic family protein [Function unknown]; Region: COG3177 331678001994 Fic/DOC family; Region: Fic; pfam02661 331678001995 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 331678001996 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 331678001997 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 331678001998 ATP binding site [chemical binding]; other site 331678001999 putative Mg++ binding site [ion binding]; other site 331678002000 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 331678002001 AAA ATPase domain; Region: AAA_16; pfam13191 331678002002 Predicted transcriptional regulator [Transcription]; Region: COG3905 331678002003 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 331678002004 Transposase domain (DUF772); Region: DUF772; pfam05598 331678002005 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 331678002006 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331678002007 sequence-specific DNA binding site [nucleotide binding]; other site 331678002008 salt bridge; other site 331678002009 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 331678002010 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 331678002011 oligomeric interface; other site 331678002012 putative active site [active] 331678002013 homodimer interface [polypeptide binding]; other site 331678002014 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 331678002015 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 331678002016 2TM domain; Region: 2TM; pfam13239 331678002017 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 331678002018 PemK-like protein; Region: PemK; pfam02452 331678002019 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 331678002020 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 331678002021 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 331678002022 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 331678002023 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 331678002024 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 331678002025 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 331678002026 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 331678002027 mobile mystery protein A; Region: mob_myst_A; TIGR02612 331678002028 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331678002029 non-specific DNA binding site [nucleotide binding]; other site 331678002030 salt bridge; other site 331678002031 sequence-specific DNA binding site [nucleotide binding]; other site 331678002032 mobile mystery protein B; Region: mob_myst_B; TIGR02613 331678002033 Fic/DOC family; Region: Fic; pfam02661 331678002034 AAA domain; Region: AAA_11; pfam13086 331678002035 Part of AAA domain; Region: AAA_19; pfam13245 331678002036 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 331678002037 AAA domain; Region: AAA_12; pfam13087 331678002038 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 331678002039 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 331678002040 Virulence protein [General function prediction only]; Region: COG3943 331678002041 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 331678002042 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 331678002043 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 331678002044 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 331678002045 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 331678002046 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 331678002047 ATP binding site [chemical binding]; other site 331678002048 putative Mg++ binding site [ion binding]; other site 331678002049 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 331678002050 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 331678002051 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 331678002052 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 331678002053 HsdM N-terminal domain; Region: HsdM_N; pfam12161 331678002054 Methyltransferase domain; Region: Methyltransf_26; pfam13659 331678002055 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 331678002056 Endoribonuclease XendoU; Region: XendoU; pfam09412 331678002057 Lamin Tail Domain; Region: LTD; pfam00932 331678002058 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678002059 S-adenosylmethionine binding site [chemical binding]; other site 331678002060 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 331678002061 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 331678002062 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 331678002063 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 331678002064 Methyltransferase domain; Region: Methyltransf_31; pfam13847 331678002065 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678002066 S-adenosylmethionine binding site [chemical binding]; other site 331678002067 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 331678002068 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 331678002069 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 331678002070 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 331678002071 short chain dehydrogenase; Provisional; Region: PRK06197 331678002072 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 331678002073 putative NAD(P) binding site [chemical binding]; other site 331678002074 active site 331678002075 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 331678002076 AAA domain; Region: AAA_30; pfam13604 331678002077 Family description; Region: UvrD_C_2; pfam13538 331678002078 ribonuclease R; Region: RNase_R; TIGR02063 331678002079 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 331678002080 RNB domain; Region: RNB; pfam00773 331678002081 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 331678002082 RNA binding site [nucleotide binding]; other site 331678002083 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 331678002084 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 331678002085 photolyase PhrII; Region: phr2; TIGR00591 331678002086 DNA photolyase; Region: DNA_photolyase; pfam00875 331678002087 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 331678002088 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 331678002089 catalytic triad [active] 331678002090 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678002091 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 331678002092 putative transposase OrfB; Reviewed; Region: PHA02517 331678002093 HTH-like domain; Region: HTH_21; pfam13276 331678002094 Integrase core domain; Region: rve; pfam00665 331678002095 Integrase core domain; Region: rve_3; pfam13683 331678002096 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 331678002097 Transposase; Region: HTH_Tnp_1; pfam01527 331678002098 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 331678002099 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 331678002100 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 331678002101 catalytic residue [active] 331678002102 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 331678002103 active site residue [active] 331678002104 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 331678002105 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 331678002106 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678002107 catalytic residue [active] 331678002108 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 331678002109 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 331678002110 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 331678002111 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 331678002112 nucleophilic elbow; other site 331678002113 catalytic site [active] 331678002114 catalytic triad; other site 331678002115 Rrf2 family protein; Region: rrf2_super; TIGR00738 331678002116 Transcriptional regulator; Region: Rrf2; pfam02082 331678002117 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 331678002118 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 331678002119 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 331678002120 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 331678002121 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 331678002122 oligomerisation interface [polypeptide binding]; other site 331678002123 mobile loop; other site 331678002124 roof hairpin; other site 331678002125 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 331678002126 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 331678002127 ring oligomerisation interface [polypeptide binding]; other site 331678002128 ATP/Mg binding site [chemical binding]; other site 331678002129 stacking interactions; other site 331678002130 hinge regions; other site 331678002131 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 331678002132 Ligand Binding Site [chemical binding]; other site 331678002133 CAAX protease self-immunity; Region: Abi; pfam02517 331678002134 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 331678002135 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 331678002136 substrate binding site [chemical binding]; other site 331678002137 active site 331678002138 catalytic residues [active] 331678002139 heterodimer interface [polypeptide binding]; other site 331678002140 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 331678002141 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 331678002142 Probable Catalytic site; other site 331678002143 metal-binding site 331678002144 cinnamyl-alcohol dehydrogenase family protein; Region: PLN02662 331678002145 flavonoid reductase (FR), extended (e) SDRs; Region: FR_SDR_e; cd08958 331678002146 NADP binding site [chemical binding]; other site 331678002147 substrate binding site [chemical binding]; other site 331678002148 active site 331678002149 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866 331678002150 putative hydrophobic ligand binding site [chemical binding]; other site 331678002151 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866 331678002152 putative hydrophobic ligand binding site [chemical binding]; other site 331678002153 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866 331678002154 putative hydrophobic ligand binding site [chemical binding]; other site 331678002155 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347 331678002156 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 331678002157 active site 331678002158 catalytic site [active] 331678002159 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913 331678002160 aromatic arch; other site 331678002161 DCoH dimer interaction site [polypeptide binding]; other site 331678002162 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 331678002163 DCoH tetramer interaction site [polypeptide binding]; other site 331678002164 substrate binding site [chemical binding]; other site 331678002165 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 331678002166 Part of AAA domain; Region: AAA_19; pfam13245 331678002167 Family description; Region: UvrD_C_2; pfam13538 331678002168 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 331678002169 Flavoprotein; Region: Flavoprotein; cl08021 331678002170 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 331678002171 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 331678002172 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 331678002173 P loop; other site 331678002174 Nucleotide binding site [chemical binding]; other site 331678002175 DTAP/Switch II; other site 331678002176 Switch I; other site 331678002177 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 331678002178 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 331678002179 NAD binding site [chemical binding]; other site 331678002180 homotetramer interface [polypeptide binding]; other site 331678002181 homodimer interface [polypeptide binding]; other site 331678002182 substrate binding site [chemical binding]; other site 331678002183 active site 331678002184 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 331678002185 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 331678002186 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 331678002187 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 331678002188 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 331678002189 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 331678002190 active site 331678002191 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 331678002192 TSCPD domain; Region: TSCPD; pfam12637 331678002193 Predicted transcriptional regulator [Transcription]; Region: COG3905 331678002194 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 331678002195 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 331678002196 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331678002197 Walker A/P-loop; other site 331678002198 ATP binding site [chemical binding]; other site 331678002199 Q-loop/lid; other site 331678002200 ABC transporter signature motif; other site 331678002201 Walker B; other site 331678002202 D-loop; other site 331678002203 H-loop/switch region; other site 331678002204 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 331678002205 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 331678002206 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 331678002207 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 331678002208 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 331678002209 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 331678002210 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 331678002211 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 331678002212 ATP binding site [chemical binding]; other site 331678002213 Mg++ binding site [ion binding]; other site 331678002214 motif III; other site 331678002215 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 331678002216 nucleotide binding region [chemical binding]; other site 331678002217 ATP-binding site [chemical binding]; other site 331678002218 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 331678002219 putative RNA binding site [nucleotide binding]; other site 331678002220 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 331678002221 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 331678002222 putative metal binding site [ion binding]; other site 331678002223 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 331678002224 putative catalytic site [active] 331678002225 putative phosphate binding site [ion binding]; other site 331678002226 putative metal binding site [ion binding]; other site 331678002227 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 331678002228 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 331678002229 Beta-Casp domain; Region: Beta-Casp; smart01027 331678002230 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 331678002231 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 331678002232 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 331678002233 active site 331678002234 Int/Topo IB signature motif; other site 331678002235 16S rRNA methyltransferase B; Provisional; Region: PRK14904 331678002236 NusB family; Region: NusB; pfam01029 331678002237 putative RNA binding site [nucleotide binding]; other site 331678002238 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678002239 S-adenosylmethionine binding site [chemical binding]; other site 331678002240 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 331678002241 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 331678002242 homodimer interface [polypeptide binding]; other site 331678002243 substrate-cofactor binding pocket; other site 331678002244 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678002245 catalytic residue [active] 331678002246 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 331678002247 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 331678002248 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 331678002249 Restriction endonuclease [Defense mechanisms]; Region: COG3587 331678002250 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 331678002251 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 331678002252 seryl-tRNA synthetase; Provisional; Region: PRK05431 331678002253 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 331678002254 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 331678002255 dimer interface [polypeptide binding]; other site 331678002256 active site 331678002257 motif 1; other site 331678002258 motif 2; other site 331678002259 motif 3; other site 331678002260 Yqey-like protein; Region: YqeY; pfam09424 331678002261 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 331678002262 classical (c) SDRs; Region: SDR_c; cd05233 331678002263 NAD(P) binding site [chemical binding]; other site 331678002264 active site 331678002265 Transposase domain (DUF772); Region: DUF772; pfam05598 331678002266 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 331678002267 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 331678002268 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 331678002269 DNA-binding site [nucleotide binding]; DNA binding site 331678002270 RNA-binding motif; other site 331678002271 hypothetical protein; Reviewed; Region: PRK00024 331678002272 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 331678002273 MPN+ (JAMM) motif; other site 331678002274 Zinc-binding site [ion binding]; other site 331678002275 malate dehydrogenase; Reviewed; Region: PRK06223 331678002276 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 331678002277 NAD(P) binding site [chemical binding]; other site 331678002278 dimer interface [polypeptide binding]; other site 331678002279 tetramer (dimer of dimers) interface [polypeptide binding]; other site 331678002280 substrate binding site [chemical binding]; other site 331678002281 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 331678002282 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 331678002283 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 331678002284 MutS domain I; Region: MutS_I; pfam01624 331678002285 MutS domain II; Region: MutS_II; pfam05188 331678002286 MutS domain III; Region: MutS_III; pfam05192 331678002287 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 331678002288 Walker A/P-loop; other site 331678002289 ATP binding site [chemical binding]; other site 331678002290 Q-loop/lid; other site 331678002291 ABC transporter signature motif; other site 331678002292 Walker B; other site 331678002293 D-loop; other site 331678002294 H-loop/switch region; other site 331678002295 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 331678002296 B12 binding site [chemical binding]; other site 331678002297 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 331678002298 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678002299 FeS/SAM binding site; other site 331678002300 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 331678002301 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 331678002302 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331678002303 Walker A/P-loop; other site 331678002304 ATP binding site [chemical binding]; other site 331678002305 Q-loop/lid; other site 331678002306 ABC transporter signature motif; other site 331678002307 Walker B; other site 331678002308 D-loop; other site 331678002309 H-loop/switch region; other site 331678002310 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 331678002311 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 331678002312 DNA binding residues [nucleotide binding] 331678002313 Bacteriochlorophyll A protein; Region: BChl_A; pfam02327 331678002314 Cytidylyltransferase family; Region: CTP_transf_1; cl17467 331678002315 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 331678002316 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 331678002317 putative active site [active] 331678002318 catalytic triad [active] 331678002319 putative dimer interface [polypeptide binding]; other site 331678002320 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 331678002321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678002322 Walker A motif; other site 331678002323 ATP binding site [chemical binding]; other site 331678002324 Walker B motif; other site 331678002325 arginine finger; other site 331678002326 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 331678002327 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14616 331678002328 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 331678002329 Predicted amidohydrolase [General function prediction only]; Region: COG0388 331678002330 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_8; cd07586 331678002331 putative active site [active] 331678002332 catalytic triad [active] 331678002333 putative dimer interface [polypeptide binding]; other site 331678002334 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 331678002335 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 331678002336 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 331678002337 dimer interface [polypeptide binding]; other site 331678002338 decamer (pentamer of dimers) interface [polypeptide binding]; other site 331678002339 catalytic triad [active] 331678002340 peroxidatic and resolving cysteines [active] 331678002341 prolyl-tRNA synthetase; Provisional; Region: PRK08661 331678002342 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 331678002343 dimer interface [polypeptide binding]; other site 331678002344 motif 1; other site 331678002345 active site 331678002346 motif 2; other site 331678002347 motif 3; other site 331678002348 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 331678002349 anticodon binding site; other site 331678002350 zinc-binding site [ion binding]; other site 331678002351 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 331678002352 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 331678002353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678002354 S-adenosylmethionine binding site [chemical binding]; other site 331678002355 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 331678002356 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 331678002357 GrpE; Region: GrpE; pfam01025 331678002358 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 331678002359 dimer interface [polypeptide binding]; other site 331678002360 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 331678002361 chaperone protein DnaJ; Provisional; Region: PRK14281 331678002362 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 331678002363 HSP70 interaction site [polypeptide binding]; other site 331678002364 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 331678002365 substrate binding site [polypeptide binding]; other site 331678002366 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 331678002367 Zn binding sites [ion binding]; other site 331678002368 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 331678002369 dimer interface [polypeptide binding]; other site 331678002370 Flavodoxin domain; Region: Flavodoxin_5; cl17428 331678002371 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 331678002372 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 331678002373 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 331678002374 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 331678002375 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 331678002376 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 331678002377 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 331678002378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331678002379 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331678002380 putative substrate translocation pore; other site 331678002381 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 331678002382 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 331678002383 Walker A/P-loop; other site 331678002384 ATP binding site [chemical binding]; other site 331678002385 Q-loop/lid; other site 331678002386 ABC transporter signature motif; other site 331678002387 Walker B; other site 331678002388 D-loop; other site 331678002389 H-loop/switch region; other site 331678002390 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 331678002391 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 331678002392 putative catalytic cysteine [active] 331678002393 Outer membrane efflux protein; Region: OEP; pfam02321 331678002394 Outer membrane efflux protein; Region: OEP; pfam02321 331678002395 HlyD family secretion protein; Region: HlyD_3; pfam13437 331678002396 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 331678002397 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 331678002398 Cupin domain; Region: Cupin_2; pfam07883 331678002399 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 331678002400 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 331678002401 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331678002402 salt bridge; other site 331678002403 non-specific DNA binding site [nucleotide binding]; other site 331678002404 sequence-specific DNA binding site [nucleotide binding]; other site 331678002405 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 331678002406 active site 331678002407 NTP binding site [chemical binding]; other site 331678002408 metal binding triad [ion binding]; metal-binding site 331678002409 antibiotic binding site [chemical binding]; other site 331678002410 Protein of unknown function DUF86; Region: DUF86; cl01031 331678002411 Restriction endonuclease NotI; Region: NotI; pfam12183 331678002412 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 331678002413 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 331678002414 Transposase; Region: HTH_Tnp_1; pfam01527 331678002415 putative transposase OrfB; Reviewed; Region: PHA02517 331678002416 HTH-like domain; Region: HTH_21; pfam13276 331678002417 Integrase core domain; Region: rve; pfam00665 331678002418 Integrase core domain; Region: rve_3; pfam13683 331678002419 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 331678002420 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 331678002421 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331678002422 sequence-specific DNA binding site [nucleotide binding]; other site 331678002423 salt bridge; other site 331678002424 Fic family protein [Function unknown]; Region: COG3177 331678002425 Fic/DOC family; Region: Fic; pfam02661 331678002426 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 331678002427 B12 binding domain; Region: B12-binding; pfam02310 331678002428 B12 binding site [chemical binding]; other site 331678002429 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678002430 Radical SAM superfamily; Region: Radical_SAM; pfam04055 331678002431 FeS/SAM binding site; other site 331678002432 gamma-glutamyl kinase; Provisional; Region: PRK05429 331678002433 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 331678002434 nucleotide binding site [chemical binding]; other site 331678002435 homotetrameric interface [polypeptide binding]; other site 331678002436 putative phosphate binding site [ion binding]; other site 331678002437 putative allosteric binding site; other site 331678002438 PUA domain; Region: PUA; pfam01472 331678002439 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 331678002440 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 331678002441 metal binding site 2 [ion binding]; metal-binding site 331678002442 putative DNA binding helix; other site 331678002443 metal binding site 1 [ion binding]; metal-binding site 331678002444 dimer interface [polypeptide binding]; other site 331678002445 structural Zn2+ binding site [ion binding]; other site 331678002446 Mechanosensitive ion channel; Region: MS_channel; pfam00924 331678002447 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 331678002448 active site 331678002449 catalytic residues [active] 331678002450 metal binding site [ion binding]; metal-binding site 331678002451 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 331678002452 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 331678002453 putative active site [active] 331678002454 substrate binding site [chemical binding]; other site 331678002455 putative cosubstrate binding site; other site 331678002456 catalytic site [active] 331678002457 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 331678002458 substrate binding site [chemical binding]; other site 331678002459 GTP-binding protein LepA; Provisional; Region: PRK05433 331678002460 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 331678002461 G1 box; other site 331678002462 putative GEF interaction site [polypeptide binding]; other site 331678002463 GTP/Mg2+ binding site [chemical binding]; other site 331678002464 Switch I region; other site 331678002465 G2 box; other site 331678002466 G3 box; other site 331678002467 Switch II region; other site 331678002468 G4 box; other site 331678002469 G5 box; other site 331678002470 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 331678002471 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 331678002472 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 331678002473 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 331678002474 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 331678002475 Catalytic site [active] 331678002476 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 331678002477 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 331678002478 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 331678002479 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 331678002480 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 331678002481 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 331678002482 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 331678002483 protein binding site [polypeptide binding]; other site 331678002484 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 331678002485 protein binding site [polypeptide binding]; other site 331678002486 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 331678002487 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 331678002488 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 331678002489 Sm and related proteins; Region: Sm_like; cl00259 331678002490 hexamer interface [polypeptide binding]; other site 331678002491 Sm1 motif; other site 331678002492 heptamer interface [polypeptide binding]; other site 331678002493 RNA binding site [nucleotide binding]; other site 331678002494 Sm2 motif; other site 331678002495 triosephosphate isomerase; Provisional; Region: PRK14567 331678002496 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 331678002497 substrate binding site [chemical binding]; other site 331678002498 dimer interface [polypeptide binding]; other site 331678002499 catalytic triad [active] 331678002500 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 331678002501 ThiC-associated domain; Region: ThiC-associated; pfam13667 331678002502 ThiC family; Region: ThiC; pfam01964 331678002503 PUCC protein; Region: PUCC; pfam03209 331678002504 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 331678002505 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678002506 FeS/SAM binding site; other site 331678002507 four helix bundle suffix domain; Region: 4helix_suffix; TIGR04258 331678002508 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 331678002509 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 331678002510 ATP binding site [chemical binding]; other site 331678002511 Mg++ binding site [ion binding]; other site 331678002512 motif III; other site 331678002513 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 331678002514 nucleotide binding region [chemical binding]; other site 331678002515 ATP-binding site [chemical binding]; other site 331678002516 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 331678002517 active site 331678002518 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 331678002519 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 331678002520 Catalytic site [active] 331678002521 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 331678002522 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 331678002523 active site 331678002524 DNA binding site [nucleotide binding] 331678002525 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 331678002526 serine acetyltransferase; Provisional; Region: cysE; PRK11132 331678002527 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 331678002528 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 331678002529 trimer interface [polypeptide binding]; other site 331678002530 active site 331678002531 substrate binding site [chemical binding]; other site 331678002532 CoA binding site [chemical binding]; other site 331678002533 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 331678002534 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 331678002535 Tetramer interface [polypeptide binding]; other site 331678002536 active site 331678002537 FMN-binding site [chemical binding]; other site 331678002538 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 331678002539 dimer interface [polypeptide binding]; other site 331678002540 active site 331678002541 aspartate-rich active site metal binding site; other site 331678002542 allosteric magnesium binding site [ion binding]; other site 331678002543 Schiff base residues; other site 331678002544 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 331678002545 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 331678002546 dimer interface [polypeptide binding]; other site 331678002547 phosphorylation site [posttranslational modification] 331678002548 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331678002549 ATP binding site [chemical binding]; other site 331678002550 Mg2+ binding site [ion binding]; other site 331678002551 G-X-G motif; other site 331678002552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331678002553 Response regulator receiver domain; Region: Response_reg; pfam00072 331678002554 active site 331678002555 phosphorylation site [posttranslational modification] 331678002556 intermolecular recognition site; other site 331678002557 dimerization interface [polypeptide binding]; other site 331678002558 Response regulator receiver domain; Region: Response_reg; pfam00072 331678002559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331678002560 active site 331678002561 phosphorylation site [posttranslational modification] 331678002562 intermolecular recognition site; other site 331678002563 dimerization interface [polypeptide binding]; other site 331678002564 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 331678002565 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 331678002566 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 331678002567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331678002568 ATP binding site [chemical binding]; other site 331678002569 Mg2+ binding site [ion binding]; other site 331678002570 G-X-G motif; other site 331678002571 Response regulator receiver domain; Region: Response_reg; pfam00072 331678002572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331678002573 active site 331678002574 phosphorylation site [posttranslational modification] 331678002575 intermolecular recognition site; other site 331678002576 dimerization interface [polypeptide binding]; other site 331678002577 Response regulator receiver domain; Region: Response_reg; pfam00072 331678002578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331678002579 active site 331678002580 phosphorylation site [posttranslational modification] 331678002581 intermolecular recognition site; other site 331678002582 dimerization interface [polypeptide binding]; other site 331678002583 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 331678002584 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 331678002585 active site 331678002586 RmuC family; Region: RmuC; pfam02646 331678002587 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 331678002588 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 331678002589 active site 331678002590 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 331678002591 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 331678002592 domain interfaces; other site 331678002593 active site 331678002594 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 331678002595 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 331678002596 tRNA; other site 331678002597 putative tRNA binding site [nucleotide binding]; other site 331678002598 putative NADP binding site [chemical binding]; other site 331678002599 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 331678002600 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 331678002601 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 331678002602 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 331678002603 G1 box; other site 331678002604 putative GEF interaction site [polypeptide binding]; other site 331678002605 GTP/Mg2+ binding site [chemical binding]; other site 331678002606 Switch I region; other site 331678002607 G2 box; other site 331678002608 G3 box; other site 331678002609 Switch II region; other site 331678002610 G4 box; other site 331678002611 G5 box; other site 331678002612 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 331678002613 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 331678002614 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 331678002615 chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016 331678002616 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 331678002617 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 331678002618 DNA binding residues [nucleotide binding] 331678002619 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202 331678002620 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 331678002621 putative NAD(P) binding site [chemical binding]; other site 331678002622 2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284 331678002623 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 331678002624 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 331678002625 peptide binding site [polypeptide binding]; other site 331678002626 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 331678002627 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 331678002628 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 331678002629 trimer interface [polypeptide binding]; other site 331678002630 active site 331678002631 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 331678002632 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331678002633 active site 331678002634 phosphorylation site [posttranslational modification] 331678002635 intermolecular recognition site; other site 331678002636 dimerization interface [polypeptide binding]; other site 331678002637 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678002638 Walker A motif; other site 331678002639 ATP binding site [chemical binding]; other site 331678002640 Walker B motif; other site 331678002641 arginine finger; other site 331678002642 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 331678002643 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 331678002644 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 331678002645 Probable Catalytic site; other site 331678002646 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 331678002647 phytoene desaturase; Region: phytoene_desat; TIGR02731 331678002648 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 331678002649 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 331678002650 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331678002651 putative DNA binding site [nucleotide binding]; other site 331678002652 putative Zn2+ binding site [ion binding]; other site 331678002653 AsnC family; Region: AsnC_trans_reg; pfam01037 331678002654 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 331678002655 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 331678002656 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 331678002657 Uncharacterized conserved protein [Function unknown]; Region: COG0432 331678002658 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678002659 pantothenate kinase; Reviewed; Region: PRK13320 331678002660 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 331678002661 active site 331678002662 dimer interface [polypeptide binding]; other site 331678002663 metal binding site [ion binding]; metal-binding site 331678002664 shikimate kinase; Reviewed; Region: aroK; PRK00131 331678002665 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 331678002666 ADP binding site [chemical binding]; other site 331678002667 magnesium binding site [ion binding]; other site 331678002668 putative shikimate binding site; other site 331678002669 glycerol kinase; Provisional; Region: glpK; PRK00047 331678002670 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 331678002671 N- and C-terminal domain interface [polypeptide binding]; other site 331678002672 active site 331678002673 MgATP binding site [chemical binding]; other site 331678002674 catalytic site [active] 331678002675 metal binding site [ion binding]; metal-binding site 331678002676 glycerol binding site [chemical binding]; other site 331678002677 homotetramer interface [polypeptide binding]; other site 331678002678 homodimer interface [polypeptide binding]; other site 331678002679 FBP binding site [chemical binding]; other site 331678002680 protein IIAGlc interface [polypeptide binding]; other site 331678002681 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 331678002682 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 331678002683 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678002684 FeS/SAM binding site; other site 331678002685 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 331678002686 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 331678002687 transcriptional activator RfaH; Region: RfaH; TIGR01955 331678002688 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), TaA; Region: NGN_SP_TaA; cd09893 331678002689 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 331678002690 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 331678002691 putative NAD(P) binding site [chemical binding]; other site 331678002692 active site 331678002693 putative substrate binding site [chemical binding]; other site 331678002694 Divergent AAA domain; Region: AAA_4; pfam04326 331678002695 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 331678002696 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 331678002697 dimer interface [polypeptide binding]; other site 331678002698 putative anticodon binding site; other site 331678002699 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 331678002700 motif 1; other site 331678002701 active site 331678002702 motif 2; other site 331678002703 motif 3; other site 331678002704 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 331678002705 active site lid residues [active] 331678002706 substrate binding pocket [chemical binding]; other site 331678002707 catalytic residues [active] 331678002708 substrate-Mg2+ binding site; other site 331678002709 aspartate-rich region 1; other site 331678002710 aspartate-rich region 2; other site 331678002711 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 331678002712 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 331678002713 HflX GTPase family; Region: HflX; cd01878 331678002714 G1 box; other site 331678002715 GTP/Mg2+ binding site [chemical binding]; other site 331678002716 Switch I region; other site 331678002717 G2 box; other site 331678002718 G3 box; other site 331678002719 Switch II region; other site 331678002720 G4 box; other site 331678002721 G5 box; other site 331678002722 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 331678002723 Protein of unknown function (DUF456); Region: DUF456; pfam04306 331678002724 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 331678002725 Putative zinc ribbon domain; Region: DUF164; pfam02591 331678002726 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 331678002727 diaminopimelate decarboxylase; Region: lysA; TIGR01048 331678002728 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 331678002729 active site 331678002730 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 331678002731 substrate binding site [chemical binding]; other site 331678002732 catalytic residues [active] 331678002733 dimer interface [polypeptide binding]; other site 331678002734 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 331678002735 FAD binding site [chemical binding]; other site 331678002736 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 331678002737 Competence protein; Region: Competence; pfam03772 331678002738 Cupin domain; Region: Cupin_2; pfam07883 331678002739 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 331678002740 dimer interface [polypeptide binding]; other site 331678002741 ADP-ribose binding site [chemical binding]; other site 331678002742 active site 331678002743 nudix motif; other site 331678002744 metal binding site [ion binding]; metal-binding site 331678002745 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 331678002746 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331678002747 dimer interface [polypeptide binding]; other site 331678002748 conserved gate region; other site 331678002749 putative PBP binding loops; other site 331678002750 ABC-ATPase subunit interface; other site 331678002751 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 331678002752 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 331678002753 5S rRNA interface [nucleotide binding]; other site 331678002754 CTC domain interface [polypeptide binding]; other site 331678002755 L16 interface [polypeptide binding]; other site 331678002756 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 331678002757 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 331678002758 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 331678002759 active site 331678002760 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 331678002761 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 331678002762 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 331678002763 trimer interface [polypeptide binding]; other site 331678002764 active site 331678002765 UDP-GlcNAc binding site [chemical binding]; other site 331678002766 lipid binding site [chemical binding]; lipid-binding site 331678002767 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 331678002768 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 331678002769 Protein of unknown function, DUF547; Region: DUF547; pfam04784 331678002770 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 331678002771 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 331678002772 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 331678002773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331678002774 active site 331678002775 phosphorylation site [posttranslational modification] 331678002776 intermolecular recognition site; other site 331678002777 dimerization interface [polypeptide binding]; other site 331678002778 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331678002779 DNA binding site [nucleotide binding] 331678002780 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 331678002781 dimerization interface [polypeptide binding]; other site 331678002782 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331678002783 dimer interface [polypeptide binding]; other site 331678002784 phosphorylation site [posttranslational modification] 331678002785 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331678002786 ATP binding site [chemical binding]; other site 331678002787 Mg2+ binding site [ion binding]; other site 331678002788 G-X-G motif; other site 331678002789 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 331678002790 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 331678002791 Cytochrome c; Region: Cytochrom_C; pfam00034 331678002792 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 331678002793 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 331678002794 ligand binding site [chemical binding]; other site 331678002795 Predicted membrane protein [Function unknown]; Region: COG3431 331678002796 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 331678002797 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 331678002798 FtsX-like permease family; Region: FtsX; pfam02687 331678002799 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 331678002800 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 331678002801 FtsX-like permease family; Region: FtsX; pfam02687 331678002802 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 331678002803 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 331678002804 Walker A/P-loop; other site 331678002805 ATP binding site [chemical binding]; other site 331678002806 Q-loop/lid; other site 331678002807 ABC transporter signature motif; other site 331678002808 Walker B; other site 331678002809 D-loop; other site 331678002810 H-loop/switch region; other site 331678002811 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 331678002812 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 331678002813 HlyD family secretion protein; Region: HlyD_3; pfam13437 331678002814 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 331678002815 TPR repeat; Region: TPR_11; pfam13414 331678002816 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 331678002817 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 331678002818 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 331678002819 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 331678002820 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 331678002821 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 331678002822 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 331678002823 oligomerization interface [polypeptide binding]; other site 331678002824 active site 331678002825 metal binding site [ion binding]; metal-binding site 331678002826 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 331678002827 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 331678002828 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 331678002829 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 331678002830 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 331678002831 putative active site [active] 331678002832 catalytic triad [active] 331678002833 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 331678002834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331678002835 putative substrate translocation pore; other site 331678002836 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 331678002837 ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214 331678002838 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14955 331678002839 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678002840 Walker A motif; other site 331678002841 ATP binding site [chemical binding]; other site 331678002842 Walker B motif; other site 331678002843 arginine finger; other site 331678002844 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 331678002845 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14954 331678002846 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 331678002847 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 331678002848 dimer interface [polypeptide binding]; other site 331678002849 anticodon binding site; other site 331678002850 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 331678002851 homodimer interface [polypeptide binding]; other site 331678002852 motif 1; other site 331678002853 active site 331678002854 motif 2; other site 331678002855 GAD domain; Region: GAD; pfam02938 331678002856 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 331678002857 active site 331678002858 motif 3; other site 331678002859 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 331678002860 PAS domain; Region: PAS_9; pfam13426 331678002861 putative active site [active] 331678002862 heme pocket [chemical binding]; other site 331678002863 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 331678002864 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678002865 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 331678002866 DNA binding residues [nucleotide binding] 331678002867 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 331678002868 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 331678002869 active site 331678002870 FMN binding site [chemical binding]; other site 331678002871 substrate binding site [chemical binding]; other site 331678002872 putative catalytic residue [active] 331678002873 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678002874 S-adenosylmethionine binding site [chemical binding]; other site 331678002875 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 331678002876 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 331678002877 B12 binding site [chemical binding]; other site 331678002878 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678002879 FeS/SAM binding site; other site 331678002880 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 331678002881 CoenzymeA binding site [chemical binding]; other site 331678002882 subunit interaction site [polypeptide binding]; other site 331678002883 PHB binding site; other site 331678002884 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 331678002885 substrate binding site; other site 331678002886 dimer interface; other site 331678002887 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 331678002888 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 331678002889 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 331678002890 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331678002891 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 331678002892 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 331678002893 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 331678002894 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 331678002895 thymidylate kinase; Validated; Region: tmk; PRK00698 331678002896 TMP-binding site; other site 331678002897 ATP-binding site [chemical binding]; other site 331678002898 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331678002899 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 331678002900 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678002901 NAD(P) binding site [chemical binding]; other site 331678002902 active site 331678002903 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 331678002904 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 331678002905 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 331678002906 dimer interface [polypeptide binding]; other site 331678002907 PYR/PP interface [polypeptide binding]; other site 331678002908 TPP binding site [chemical binding]; other site 331678002909 substrate binding site [chemical binding]; other site 331678002910 2-oxoacid ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11869 331678002911 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 331678002912 TPP-binding site [chemical binding]; other site 331678002913 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 331678002914 Transposase IS200 like; Region: Y1_Tnp; cl00848 331678002915 Staphylococcal nuclease homologues; Region: SNc; smart00318 331678002916 Catalytic site; other site 331678002917 Staphylococcal nuclease homologue; Region: SNase; pfam00565 331678002918 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 331678002919 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 331678002920 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 331678002921 ABC transporter; Region: ABC_tran_2; pfam12848 331678002922 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 331678002923 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 331678002924 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 331678002925 YXWGXW repeat (2 copies); Region: YXWGXW; pfam12779 331678002926 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 331678002927 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 331678002928 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 331678002929 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 331678002930 RNA binding surface [nucleotide binding]; other site 331678002931 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 331678002932 active site 331678002933 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 331678002934 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331678002935 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 331678002936 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 331678002937 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 331678002938 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 331678002939 active site 331678002940 Walker A motif; other site 331678002941 ATP binding site [chemical binding]; other site 331678002942 magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031 331678002943 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 331678002944 metal ion-dependent adhesion site (MIDAS); other site 331678002945 magnesium chelatase, H subunit; Region: BchH; TIGR02025 331678002946 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 331678002947 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 331678002948 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 331678002949 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 331678002950 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 331678002951 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 331678002952 active site 331678002953 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 331678002954 Protein of unknown function (DUF3680); Region: DUF3680; pfam12441 331678002955 Protein of unknown function (DUF497); Region: DUF497; pfam04365 331678002956 PIN domain; Region: PIN_3; cl17397 331678002957 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 331678002958 Methyltransferase domain; Region: Methyltransf_31; pfam13847 331678002959 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678002960 S-adenosylmethionine binding site [chemical binding]; other site 331678002961 Putative addiction module component; Region: Unstab_antitox; pfam09720 331678002962 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 331678002963 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 331678002964 ArsC family; Region: ArsC; pfam03960 331678002965 putative catalytic residues [active] 331678002966 Helix-turn-helix domain; Region: HTH_17; pfam12728 331678002967 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 331678002968 DNA methylase; Region: N6_N4_Mtase; pfam01555 331678002969 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 331678002970 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 331678002971 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 331678002972 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 331678002973 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 331678002974 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 331678002975 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 331678002976 HlyD family secretion protein; Region: HlyD_3; pfam13437 331678002977 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 331678002978 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 331678002979 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 331678002980 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 331678002981 catalytic residues [active] 331678002982 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 331678002983 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 331678002984 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 331678002985 methionine sulfoxide reductase A; Provisional; Region: PRK14054 331678002986 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 331678002987 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678002988 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 331678002989 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 331678002990 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 331678002991 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678002992 Protein of unknown function DUF86; Region: DUF86; cl01031 331678002993 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 331678002994 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 331678002995 putative NAD(P) binding site [chemical binding]; other site 331678002996 putative substrate binding site [chemical binding]; other site 331678002997 catalytic Zn binding site [ion binding]; other site 331678002998 structural Zn binding site [ion binding]; other site 331678002999 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 331678003000 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 331678003001 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 331678003002 active site 331678003003 Uncharacterized conserved protein [Function unknown]; Region: COG0432 331678003004 bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566 331678003005 UbiA prenyltransferase family; Region: UbiA; pfam01040 331678003006 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 331678003007 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 331678003008 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 331678003009 PhoH-like protein; Region: PhoH; pfam02562 331678003010 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 331678003011 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 331678003012 NADP binding site [chemical binding]; other site 331678003013 homopentamer interface [polypeptide binding]; other site 331678003014 substrate binding site [chemical binding]; other site 331678003015 active site 331678003016 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 331678003017 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 331678003018 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331678003019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678003020 homodimer interface [polypeptide binding]; other site 331678003021 catalytic residue [active] 331678003022 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 331678003023 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 331678003024 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331678003025 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 331678003026 putative active site [active] 331678003027 catalytic residue [active] 331678003028 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 331678003029 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 331678003030 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 331678003031 putative catalytic site [active] 331678003032 putative metal binding site [ion binding]; other site 331678003033 putative phosphate binding site [ion binding]; other site 331678003034 EamA-like transporter family; Region: EamA; cl17759 331678003035 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 331678003036 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 331678003037 ATP binding site [chemical binding]; other site 331678003038 active site 331678003039 substrate binding site [chemical binding]; other site 331678003040 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 331678003041 transketolase; Reviewed; Region: PRK05899 331678003042 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 331678003043 TPP-binding site [chemical binding]; other site 331678003044 dimer interface [polypeptide binding]; other site 331678003045 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 331678003046 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678003047 S-adenosylmethionine binding site [chemical binding]; other site 331678003048 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 331678003049 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 331678003050 active site 331678003051 (T/H)XGH motif; other site 331678003052 aspartate aminotransferase; Provisional; Region: PRK05764 331678003053 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331678003054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678003055 homodimer interface [polypeptide binding]; other site 331678003056 catalytic residue [active] 331678003057 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 331678003058 putative acyl-acceptor binding pocket; other site 331678003059 PSP1 C-terminal conserved region; Region: PSP1; pfam04468 331678003060 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 331678003061 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 331678003062 active site 331678003063 HIGH motif; other site 331678003064 KMSKS motif; other site 331678003065 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 331678003066 tRNA binding surface [nucleotide binding]; other site 331678003067 anticodon binding site; other site 331678003068 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 331678003069 dimer interface [polypeptide binding]; other site 331678003070 putative tRNA-binding site [nucleotide binding]; other site 331678003071 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 331678003072 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 331678003073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678003074 S-adenosylmethionine binding site [chemical binding]; other site 331678003075 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 331678003076 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 331678003077 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 331678003078 anti sigma factor interaction site; other site 331678003079 regulatory phosphorylation site [posttranslational modification]; other site 331678003080 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 331678003081 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 331678003082 Maf-like protein; Region: Maf; pfam02545 331678003083 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 331678003084 active site 331678003085 dimer interface [polypeptide binding]; other site 331678003086 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 331678003087 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 331678003088 Na binding site [ion binding]; other site 331678003089 Ribokinase-like subgroup C. Found only in bacteria, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_C; cd01946 331678003090 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 331678003091 substrate binding site [chemical binding]; other site 331678003092 ATP binding site [chemical binding]; other site 331678003093 Alpha amylase catalytic domain found in maltosyltransferase; Region: AmyAc_MTase_N; cd11335 331678003094 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 331678003095 homodimer interface [polypeptide binding]; other site 331678003096 active site 331678003097 catalytic site [active] 331678003098 maltose binding site 2 [chemical binding]; other site 331678003099 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 331678003100 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 331678003101 dimerization interface 3.5A [polypeptide binding]; other site 331678003102 active site 331678003103 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 331678003104 N-acetyl-D-glucosamine binding site [chemical binding]; other site 331678003105 catalytic residue [active] 331678003106 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 331678003107 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 331678003108 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 331678003109 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 331678003110 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 331678003111 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 331678003112 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 331678003113 P loop; other site 331678003114 Nucleotide binding site [chemical binding]; other site 331678003115 DTAP/Switch II; other site 331678003116 Switch I; other site 331678003117 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 331678003118 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 331678003119 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 331678003120 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 331678003121 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 331678003122 Walker A/P-loop; other site 331678003123 ATP binding site [chemical binding]; other site 331678003124 Q-loop/lid; other site 331678003125 ABC transporter signature motif; other site 331678003126 Walker B; other site 331678003127 D-loop; other site 331678003128 H-loop/switch region; other site 331678003129 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 331678003130 cobalt transport protein CbiM; Validated; Region: PRK06265 331678003131 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 331678003132 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 331678003133 nickel responsive regulator; Provisional; Region: PRK04460 331678003134 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 331678003135 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 331678003136 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 331678003137 Nitrogen regulatory protein P-II; Region: P-II; smart00938 331678003138 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 331678003139 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 331678003140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 331678003141 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 331678003142 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 331678003143 active site 331678003144 dimer interface [polypeptide binding]; other site 331678003145 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 331678003146 dimer interface [polypeptide binding]; other site 331678003147 active site 331678003148 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 331678003149 ApbE family; Region: ApbE; pfam02424 331678003150 integron integrase; Region: integrase_gron; TIGR02249 331678003151 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 331678003152 Int/Topo IB signature motif; other site 331678003153 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311 331678003154 putative active site [active] 331678003155 catalytic site [active] 331678003156 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 331678003157 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 331678003158 ATP binding site [chemical binding]; other site 331678003159 putative Mg++ binding site [ion binding]; other site 331678003160 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 331678003161 nucleotide binding region [chemical binding]; other site 331678003162 ATP-binding site [chemical binding]; other site 331678003163 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 331678003164 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 331678003165 DNA methylase; Region: N6_N4_Mtase; pfam01555 331678003166 DNA methylase; Region: N6_N4_Mtase; cl17433 331678003167 Restriction endonuclease [Defense mechanisms]; Region: COG3587 331678003168 Uncharacterized conserved protein [Function unknown]; Region: COG1479 331678003169 Protein of unknown function DUF262; Region: DUF262; pfam03235 331678003170 Protein of unknown function DUF262; Region: DUF262; pfam03235 331678003171 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 331678003172 AAA domain; Region: AAA_13; pfam13166 331678003173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 331678003174 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 331678003175 putative active site [active] 331678003176 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 331678003177 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 331678003178 Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651 331678003179 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678003180 Protein of unknown function DUF262; Region: DUF262; pfam03235 331678003181 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 331678003182 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 331678003183 active site 331678003184 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 331678003185 Uncharacterized conserved protein [Function unknown]; Region: COG3586 331678003186 Uncharacterized protein family (UPF0156); Region: RHH_2; pfam03693 331678003187 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 331678003188 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 331678003189 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 331678003190 SprT homologues; Region: SprT; cl01182 331678003191 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 331678003192 Ligand Binding Site [chemical binding]; other site 331678003193 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 331678003194 Ligand Binding Site [chemical binding]; other site 331678003195 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 331678003196 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 331678003197 Sulfate transporter family; Region: Sulfate_transp; pfam00916 331678003198 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 331678003199 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 331678003200 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 331678003201 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 331678003202 dimer interface [polypeptide binding]; other site 331678003203 active site residues [active] 331678003204 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 331678003205 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 331678003206 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 331678003207 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 331678003208 Ligand Binding Site [chemical binding]; other site 331678003209 membrane ATPase/protein kinase; Provisional; Region: PRK09435 331678003210 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 331678003211 Walker A; other site 331678003212 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 331678003213 G4 box; other site 331678003214 G5 box; other site 331678003215 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 331678003216 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 331678003217 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 331678003218 active site 331678003219 substrate binding site [chemical binding]; other site 331678003220 coenzyme B12 binding site [chemical binding]; other site 331678003221 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 331678003222 B12 binding site [chemical binding]; other site 331678003223 cobalt ligand [ion binding]; other site 331678003224 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 331678003225 trimer interface [polypeptide binding]; other site 331678003226 oxyanion hole (OAH) forming residues; other site 331678003227 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 331678003228 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 331678003229 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 331678003230 dimer interface [polypeptide binding]; other site 331678003231 substrate binding site [chemical binding]; other site 331678003232 metal binding site [ion binding]; metal-binding site 331678003233 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 331678003234 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 331678003235 acyl-activating enzyme (AAE) consensus motif; other site 331678003236 putative AMP binding site [chemical binding]; other site 331678003237 putative active site [active] 331678003238 putative CoA binding site [chemical binding]; other site 331678003239 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 331678003240 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678003241 S-adenosylmethionine binding site [chemical binding]; other site 331678003242 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 331678003243 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 331678003244 PYR/PP interface [polypeptide binding]; other site 331678003245 dimer interface [polypeptide binding]; other site 331678003246 TPP binding site [chemical binding]; other site 331678003247 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 331678003248 hypothetical protein; Provisional; Region: PRK14621 331678003249 recombination protein RecR; Reviewed; Region: recR; PRK00076 331678003250 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 331678003251 RecR protein; Region: RecR; pfam02132 331678003252 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 331678003253 putative active site [active] 331678003254 putative metal-binding site [ion binding]; other site 331678003255 tetramer interface [polypeptide binding]; other site 331678003256 phytoene desaturase; Region: phytoene_desat; TIGR02731 331678003257 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 331678003258 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 331678003259 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 331678003260 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678003261 S-adenosylmethionine binding site [chemical binding]; other site 331678003262 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 331678003263 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 331678003264 active site 331678003265 catalytic tetrad [active] 331678003266 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 331678003267 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 331678003268 G1 box; other site 331678003269 putative GEF interaction site [polypeptide binding]; other site 331678003270 GTP/Mg2+ binding site [chemical binding]; other site 331678003271 Switch I region; other site 331678003272 G2 box; other site 331678003273 G3 box; other site 331678003274 Switch II region; other site 331678003275 G4 box; other site 331678003276 G5 box; other site 331678003277 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 331678003278 phosphoglucomutase; Validated; Region: PRK07564 331678003279 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 331678003280 active site 331678003281 substrate binding site [chemical binding]; other site 331678003282 metal binding site [ion binding]; metal-binding site 331678003283 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 331678003284 dimer interface [polypeptide binding]; other site 331678003285 substrate binding site [chemical binding]; other site 331678003286 metal binding sites [ion binding]; metal-binding site 331678003287 fumarate hydratase; Reviewed; Region: fumC; PRK00485 331678003288 Class II fumarases; Region: Fumarase_classII; cd01362 331678003289 active site 331678003290 tetramer interface [polypeptide binding]; other site 331678003291 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 331678003292 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 331678003293 ATP cone domain; Region: ATP-cone; pfam03477 331678003294 Class III ribonucleotide reductase; Region: RNR_III; cd01675 331678003295 effector binding site; other site 331678003296 active site 331678003297 Zn binding site [ion binding]; other site 331678003298 glycine loop; other site 331678003299 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 331678003300 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678003301 FeS/SAM binding site; other site 331678003302 putative molybdenum utilization protein ModD; Region: modD; TIGR01334 331678003303 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 331678003304 dimerization interface [polypeptide binding]; other site 331678003305 active site 331678003306 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 331678003307 heat shock protein 90; Provisional; Region: PRK05218 331678003308 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331678003309 ATP binding site [chemical binding]; other site 331678003310 Mg2+ binding site [ion binding]; other site 331678003311 G-X-G motif; other site 331678003312 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 331678003313 diiron binding motif [ion binding]; other site 331678003314 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 331678003315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 331678003316 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 331678003317 AAA domain; Region: AAA_33; pfam13671 331678003318 ATP-binding site [chemical binding]; other site 331678003319 Gluconate-6-phosphate binding site [chemical binding]; other site 331678003320 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 331678003321 Ligand Binding Site [chemical binding]; other site 331678003322 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 331678003323 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 331678003324 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 331678003325 active site 331678003326 catalytic residues [active] 331678003327 metal binding site [ion binding]; metal-binding site 331678003328 homodimer binding site [polypeptide binding]; other site 331678003329 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 331678003330 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 331678003331 carboxyltransferase (CT) interaction site; other site 331678003332 biotinylation site [posttranslational modification]; other site 331678003333 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 331678003334 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 331678003335 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 331678003336 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 331678003337 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 331678003338 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 331678003339 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 331678003340 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 331678003341 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 331678003342 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 331678003343 putative ADP-binding pocket [chemical binding]; other site 331678003344 DNA polymerase III subunit alpha; partial due to frameshift 331678003345 DNA polymerase III subunit alpha; partial due to frameshift 331678003346 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 331678003347 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 331678003348 catalytic residues [active] 331678003349 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 331678003350 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 331678003351 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331678003352 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 331678003353 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 331678003354 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 331678003355 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 331678003356 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 331678003357 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 331678003358 putative active site [active] 331678003359 putative metal binding site [ion binding]; other site 331678003360 SdiA-regulated; Region: SdiA-regulated; cd09971 331678003361 putative active site [active] 331678003362 Surface antigen; Region: Bac_surface_Ag; pfam01103 331678003363 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 331678003364 cyclase homology domain; Region: CHD; cd07302 331678003365 nucleotidyl binding site; other site 331678003366 metal binding site [ion binding]; metal-binding site 331678003367 dimer interface [polypeptide binding]; other site 331678003368 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 331678003369 Zn2+ binding site [ion binding]; other site 331678003370 Mg2+ binding site [ion binding]; other site 331678003371 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 331678003372 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 331678003373 active site 331678003374 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 331678003375 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331678003376 motif II; other site 331678003377 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678003378 hypothetical protein; Provisional; Region: PRK08317 331678003379 S-adenosylmethionine binding site [chemical binding]; other site 331678003380 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 331678003381 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 331678003382 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 331678003383 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 331678003384 putative acyl-acceptor binding pocket; other site 331678003385 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 331678003386 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 331678003387 PBP superfamily domain; Region: PBP_like_2; cl17296 331678003388 PBP superfamily domain; Region: PBP_like_2; cl17296 331678003389 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 331678003390 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 331678003391 Walker A/P-loop; other site 331678003392 ATP binding site [chemical binding]; other site 331678003393 Q-loop/lid; other site 331678003394 ABC transporter signature motif; other site 331678003395 Walker B; other site 331678003396 D-loop; other site 331678003397 H-loop/switch region; other site 331678003398 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 331678003399 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 331678003400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331678003401 dimer interface [polypeptide binding]; other site 331678003402 conserved gate region; other site 331678003403 putative PBP binding loops; other site 331678003404 ABC-ATPase subunit interface; other site 331678003405 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 331678003406 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 331678003407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331678003408 dimer interface [polypeptide binding]; other site 331678003409 conserved gate region; other site 331678003410 putative PBP binding loops; other site 331678003411 ABC-ATPase subunit interface; other site 331678003412 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 331678003413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331678003414 conserved gate region; other site 331678003415 putative PBP binding loops; other site 331678003416 ABC-ATPase subunit interface; other site 331678003417 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 331678003418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 331678003419 dimer interface [polypeptide binding]; other site 331678003420 conserved gate region; other site 331678003421 putative PBP binding loops; other site 331678003422 ABC-ATPase subunit interface; other site 331678003423 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14275 331678003424 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 331678003425 Walker A/P-loop; other site 331678003426 ATP binding site [chemical binding]; other site 331678003427 Q-loop/lid; other site 331678003428 ABC transporter signature motif; other site 331678003429 Walker B; other site 331678003430 D-loop; other site 331678003431 H-loop/switch region; other site 331678003432 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 331678003433 PhoU domain; Region: PhoU; pfam01895 331678003434 PhoU domain; Region: PhoU; pfam01895 331678003435 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 331678003436 PhoU domain; Region: PhoU; pfam01895 331678003437 PhoU domain; Region: PhoU; pfam01895 331678003438 DoxX-like family; Region: DoxX_3; pfam13781 331678003439 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 331678003440 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 331678003441 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 331678003442 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 331678003443 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 331678003444 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 331678003445 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 331678003446 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 331678003447 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 331678003448 active site 331678003449 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 331678003450 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 331678003451 DNA methylase; Region: N6_N4_Mtase; pfam01555 331678003452 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 331678003453 CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578 331678003454 DDE superfamily endonuclease; Region: DDE_3; pfam13358 331678003455 Winged helix-turn helix; Region: HTH_29; pfam13551 331678003456 Homeodomain-like domain; Region: HTH_23; pfam13384 331678003457 Homeodomain-like domain; Region: HTH_32; pfam13565 331678003458 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622 331678003459 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 331678003460 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438 331678003461 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437 331678003462 Uncharacterized conserved protein (DUF2276); Region: DUF2276; pfam10040 331678003463 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678003464 Putative addiction module component; Region: Unstab_antitox; pfam09720 331678003465 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 331678003466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304 331678003467 Protein of unknown function (DUF497); Region: DUF497; cl01108 331678003468 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 331678003469 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 331678003470 FAD binding domain; Region: FAD_binding_4; pfam01565 331678003471 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 331678003472 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 331678003473 Cysteine-rich domain; Region: CCG; pfam02754 331678003474 radical SAM modification target peptide, selenobiotic family; Region: selen_ocin; TIGR04081 331678003475 selenobiotic family peptide radical SAM maturase; Region: rSAM_for_selen; TIGR04082 331678003476 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678003477 FeS/SAM binding site; other site 331678003478 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 331678003479 aspartate aminotransferase; Provisional; Region: PRK08636 331678003480 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331678003481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678003482 homodimer interface [polypeptide binding]; other site 331678003483 catalytic residue [active] 331678003484 Phophatidylserine decarboxylase; Region: PSDC; pfam12588 331678003485 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 331678003486 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 331678003487 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 331678003488 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 331678003489 putative substrate binding site [chemical binding]; other site 331678003490 putative ATP binding site [chemical binding]; other site 331678003491 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 331678003492 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 331678003493 dimerization interface [polypeptide binding]; other site 331678003494 ATP binding site [chemical binding]; other site 331678003495 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 331678003496 dimerization interface [polypeptide binding]; other site 331678003497 ATP binding site [chemical binding]; other site 331678003498 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12900 331678003499 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 331678003500 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 331678003501 nucleotide binding region [chemical binding]; other site 331678003502 ATP-binding site [chemical binding]; other site 331678003503 SEC-C motif; Region: SEC-C; pfam02810 331678003504 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 331678003505 DHH family; Region: DHH; pfam01368 331678003506 DHHA1 domain; Region: DHHA1; pfam02272 331678003507 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 331678003508 Biogenesis of lysosome-related organelles complex-1 subunit 2; Region: BLOC1_2; pfam10046 331678003509 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 331678003510 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 331678003511 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 331678003512 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 331678003513 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 331678003514 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 331678003515 dimer interface [polypeptide binding]; other site 331678003516 substrate binding site [chemical binding]; other site 331678003517 ATP binding site [chemical binding]; other site 331678003518 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 331678003519 thiamine phosphate binding site [chemical binding]; other site 331678003520 active site 331678003521 pyrophosphate binding site [ion binding]; other site 331678003522 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 331678003523 thiamine phosphate binding site [chemical binding]; other site 331678003524 active site 331678003525 pyrophosphate binding site [ion binding]; other site 331678003526 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 331678003527 homotrimer interaction site [polypeptide binding]; other site 331678003528 putative active site [active] 331678003529 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 331678003530 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 331678003531 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 331678003532 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 331678003533 protein binding site [polypeptide binding]; other site 331678003534 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 331678003535 Catalytic dyad [active] 331678003536 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 331678003537 putative lipid binding site [chemical binding]; other site 331678003538 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 331678003539 putative lipid binding site [chemical binding]; other site 331678003540 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 331678003541 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 331678003542 putative ribose interaction site [chemical binding]; other site 331678003543 putative ADP binding site [chemical binding]; other site 331678003544 signal recognition particle protein; Provisional; Region: PRK10867 331678003545 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 331678003546 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 331678003547 P loop; other site 331678003548 GTP binding site [chemical binding]; other site 331678003549 Signal peptide binding domain; Region: SRP_SPB; pfam02978 331678003550 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 331678003551 16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273 331678003552 RimM N-terminal domain; Region: RimM; pfam01782 331678003553 PRC-barrel domain; Region: PRC; pfam05239 331678003554 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 331678003555 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 331678003556 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 331678003557 endonuclease III; Region: ENDO3c; smart00478 331678003558 minor groove reading motif; other site 331678003559 helix-hairpin-helix signature motif; other site 331678003560 substrate binding pocket [chemical binding]; other site 331678003561 active site 331678003562 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 331678003563 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 331678003564 acyl-activating enzyme (AAE) consensus motif; other site 331678003565 putative AMP binding site [chemical binding]; other site 331678003566 putative active site [active] 331678003567 putative CoA binding site [chemical binding]; other site 331678003568 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 331678003569 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 331678003570 P-loop; other site 331678003571 Magnesium ion binding site [ion binding]; other site 331678003572 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 331678003573 Magnesium ion binding site [ion binding]; other site 331678003574 CHAD domain; Region: CHAD; pfam05235 331678003575 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 331678003576 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 331678003577 ligand binding site [chemical binding]; other site 331678003578 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 331678003579 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 331678003580 putative NADP binding site [chemical binding]; other site 331678003581 putative substrate binding site [chemical binding]; other site 331678003582 active site 331678003583 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 331678003584 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 331678003585 ligand binding site [chemical binding]; other site 331678003586 flexible hinge region; other site 331678003587 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 331678003588 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 331678003589 metal binding triad; other site 331678003590 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 331678003591 active site 331678003592 catalytic site [active] 331678003593 substrate binding site [chemical binding]; other site 331678003594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678003595 S-adenosylmethionine binding site [chemical binding]; other site 331678003596 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 331678003597 active site residue [active] 331678003598 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 331678003599 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 331678003600 active site residue [active] 331678003601 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 331678003602 active site residue [active] 331678003603 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 331678003604 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 331678003605 Predicted amidohydrolase [General function prediction only]; Region: COG0388 331678003606 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 331678003607 putative active site [active] 331678003608 catalytic triad [active] 331678003609 putative dimer interface [polypeptide binding]; other site 331678003610 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 331678003611 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 331678003612 putative addiction module antidote; Region: doc_partner; TIGR02609 331678003613 Putative addiction module component; Region: Unstab_antitox; pfam09720 331678003614 dihydroorotase; Validated; Region: pyrC; PRK09357 331678003615 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 331678003616 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 331678003617 active site 331678003618 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 331678003619 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 331678003620 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 331678003621 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 331678003622 polyphosphate kinase; Provisional; Region: PRK05443 331678003623 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 331678003624 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 331678003625 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 331678003626 putative domain interface [polypeptide binding]; other site 331678003627 putative active site [active] 331678003628 catalytic site [active] 331678003629 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 331678003630 putative domain interface [polypeptide binding]; other site 331678003631 putative active site [active] 331678003632 catalytic site [active] 331678003633 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 331678003634 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 331678003635 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 331678003636 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 331678003637 metal binding site [ion binding]; metal-binding site 331678003638 dimer interface [polypeptide binding]; other site 331678003639 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 331678003640 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 331678003641 intersubunit interface [polypeptide binding]; other site 331678003642 active site 331678003643 zinc binding site [ion binding]; other site 331678003644 Na+ binding site [ion binding]; other site 331678003645 carboxy-terminal protease; Provisional; Region: PRK11186 331678003646 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 331678003647 protein binding site [polypeptide binding]; other site 331678003648 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 331678003649 Catalytic dyad [active] 331678003650 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 331678003651 argininosuccinate lyase; Provisional; Region: PRK00855 331678003652 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 331678003653 active sites [active] 331678003654 tetramer interface [polypeptide binding]; other site 331678003655 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 331678003656 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 331678003657 argininosuccinate synthase; Provisional; Region: PRK13820 331678003658 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 331678003659 ANP binding site [chemical binding]; other site 331678003660 Substrate Binding Site II [chemical binding]; other site 331678003661 Substrate Binding Site I [chemical binding]; other site 331678003662 Arginine repressor [Transcription]; Region: ArgR; COG1438 331678003663 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 331678003664 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 331678003665 ornithine carbamoyltransferase; Provisional; Region: PRK00779 331678003666 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 331678003667 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 331678003668 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 331678003669 feedback inhibition sensing region; other site 331678003670 homohexameric interface [polypeptide binding]; other site 331678003671 nucleotide binding site [chemical binding]; other site 331678003672 N-acetyl-L-glutamate binding site [chemical binding]; other site 331678003673 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 331678003674 heterotetramer interface [polypeptide binding]; other site 331678003675 active site pocket [active] 331678003676 cleavage site 331678003677 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 331678003678 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 331678003679 PBP superfamily domain; Region: PBP_like_2; pfam12849 331678003680 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 331678003681 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 331678003682 metal binding site [ion binding]; metal-binding site 331678003683 active site 331678003684 I-site; other site 331678003685 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 331678003686 FtsX-like permease family; Region: FtsX; pfam02687 331678003687 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 331678003688 FtsX-like permease family; Region: FtsX; pfam02687 331678003689 Rubredoxin [Energy production and conversion]; Region: COG1773 331678003690 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 331678003691 iron binding site [ion binding]; other site 331678003692 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 331678003693 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331678003694 Coenzyme A binding pocket [chemical binding]; other site 331678003695 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 331678003696 Predicted membrane protein [Function unknown]; Region: COG2119 331678003697 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 331678003698 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 331678003699 Domain of unknown function DUF87; Region: DUF87; pfam01935 331678003700 AAA-like domain; Region: AAA_10; pfam12846 331678003701 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 331678003702 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 331678003703 Walker A/P-loop; other site 331678003704 ATP binding site [chemical binding]; other site 331678003705 Q-loop/lid; other site 331678003706 ABC transporter signature motif; other site 331678003707 Walker B; other site 331678003708 D-loop; other site 331678003709 H-loop/switch region; other site 331678003710 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 331678003711 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 331678003712 Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045 331678003713 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 331678003714 CoA binding domain; Region: CoA_binding; cl17356 331678003715 ATP citrate (pro-S)-lyase; Region: PLN02522 331678003716 CoA-ligase; Region: Ligase_CoA; pfam00549 331678003717 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 331678003718 active site 331678003719 oxalacetate binding site [chemical binding]; other site 331678003720 citrylCoA binding site [chemical binding]; other site 331678003721 coenzyme A binding site [chemical binding]; other site 331678003722 catalytic triad [active] 331678003723 Integrase core domain; Region: rve; pfam00665 331678003724 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 331678003725 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 331678003726 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 331678003727 putative active site [active] 331678003728 putative NTP binding site [chemical binding]; other site 331678003729 putative nucleic acid binding site [nucleotide binding]; other site 331678003730 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 331678003731 Integrase core domain; Region: rve_3; cl15866 331678003732 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 331678003733 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678003734 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 331678003735 PAS fold; Region: PAS_3; pfam08447 331678003736 putative active site [active] 331678003737 heme pocket [chemical binding]; other site 331678003738 PAS domain; Region: PAS_8; pfam13188 331678003739 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cl00787 331678003740 Transposase domain (DUF772); Region: DUF772; pfam05598 331678003741 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 331678003742 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 331678003743 Integrase core domain; Region: rve; pfam00665 331678003744 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 331678003745 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 331678003746 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678003747 Walker A motif; other site 331678003748 ATP binding site [chemical binding]; other site 331678003749 Walker B motif; other site 331678003750 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 331678003751 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 331678003752 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 331678003753 DNA binding residues [nucleotide binding] 331678003754 Putative zinc-finger; Region: zf-HC2; pfam13490 331678003755 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 331678003756 dimer interface [polypeptide binding]; other site 331678003757 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 331678003758 active site clefts [active] 331678003759 zinc binding site [ion binding]; other site 331678003760 dimer interface [polypeptide binding]; other site 331678003761 lipoyl synthase; Provisional; Region: PRK05481 331678003762 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 331678003763 FeS/SAM binding site; other site 331678003764 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 331678003765 NADH(P)-binding; Region: NAD_binding_10; pfam13460 331678003766 NAD(P) binding site [chemical binding]; other site 331678003767 putative active site [active] 331678003768 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 331678003769 classical (c) SDRs; Region: SDR_c; cd05233 331678003770 NAD(P) binding site [chemical binding]; other site 331678003771 active site 331678003772 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 331678003773 catalytic loop [active] 331678003774 iron binding site [ion binding]; other site 331678003775 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 331678003776 5-oxoprolinase; Region: PLN02666 331678003777 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 331678003778 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 331678003779 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 331678003780 Uncharacterized conserved protein [Function unknown]; Region: COG1434 331678003781 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 331678003782 putative active site [active] 331678003783 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 331678003784 NADH(P)-binding; Region: NAD_binding_10; pfam13460 331678003785 NAD(P) binding site [chemical binding]; other site 331678003786 putative active site [active] 331678003787 Domain of unknown function (DUF4071); Region: DUF4071; pfam13281 331678003788 Patatin-like phospholipase; Region: Pat17_PNPLA8_PNPLA9_like4; cd07217 331678003789 active site 331678003790 nucleophile elbow; other site 331678003791 Transposase domain (DUF772); Region: DUF772; pfam05598 331678003792 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 331678003793 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 331678003794 peptide modification radical SAM enzyme, YydG family; Region: rSAM_yydG; TIGR04078 331678003795 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678003796 FeS/SAM binding site; other site 331678003797 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678003798 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 331678003799 FeS/SAM binding site; other site 331678003800 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 331678003801 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 331678003802 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 331678003803 metal binding site [ion binding]; metal-binding site 331678003804 dimer interface [polypeptide binding]; other site 331678003805 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 331678003806 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331678003807 dimerization interface [polypeptide binding]; other site 331678003808 putative DNA binding site [nucleotide binding]; other site 331678003809 putative Zn2+ binding site [ion binding]; other site 331678003810 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 331678003811 Domain of unknown function (DUF4403); Region: DUF4403; pfam14356 331678003812 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 331678003813 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678003814 NAD(P) binding site [chemical binding]; other site 331678003815 active site 331678003816 SnoaL-like domain; Region: SnoaL_3; pfam13474 331678003817 putative geopeptide radical SAM maturase; Region: geopep_mat_rSAM; TIGR04280 331678003818 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678003819 FeS/SAM binding site; other site 331678003820 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 331678003821 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 331678003822 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 331678003823 acyl-activating enzyme (AAE) consensus motif; other site 331678003824 AMP binding site [chemical binding]; other site 331678003825 active site 331678003826 CoA binding site [chemical binding]; other site 331678003827 xanthine permease; Region: pbuX; TIGR03173 331678003828 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 331678003829 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 331678003830 putative active site [active] 331678003831 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 331678003832 Radical SAM superfamily; Region: Radical_SAM; pfam04055 331678003833 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678003834 FeS/SAM binding site; other site 331678003835 8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588 331678003836 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 331678003837 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 331678003838 minor groove reading motif; other site 331678003839 helix-hairpin-helix signature motif; other site 331678003840 substrate binding pocket [chemical binding]; other site 331678003841 active site 331678003842 Peptidase family M48; Region: Peptidase_M48; pfam01435 331678003843 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 331678003844 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 331678003845 NAD(P) binding site [chemical binding]; other site 331678003846 putative active site [active] 331678003847 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 331678003848 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 331678003849 Zn binding site [ion binding]; other site 331678003850 Protein of unknown function, DUF399; Region: DUF399; pfam04187 331678003851 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 331678003852 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 331678003853 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 331678003854 additional DNA contacts [nucleotide binding]; other site 331678003855 mismatch recognition site; other site 331678003856 active site 331678003857 zinc binding site [ion binding]; other site 331678003858 DNA intercalation site [nucleotide binding]; other site 331678003859 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 331678003860 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 331678003861 cofactor binding site; other site 331678003862 DNA binding site [nucleotide binding] 331678003863 substrate interaction site [chemical binding]; other site 331678003864 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 331678003865 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 331678003866 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 331678003867 ATP-binding site [chemical binding]; other site 331678003868 Nuclease-related domain; Region: NERD; pfam08378 331678003869 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 331678003870 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 331678003871 Family description; Region: UvrD_C_2; pfam13538 331678003872 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 331678003873 Repair protein; Region: Repair_PSII; pfam04536 331678003874 Repair protein; Region: Repair_PSII; cl01535 331678003875 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 331678003876 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678003877 FeS/SAM binding site; other site 331678003878 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 331678003879 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 331678003880 NADH(P)-binding; Region: NAD_binding_10; pfam13460 331678003881 NAD(P) binding site [chemical binding]; other site 331678003882 putative active site [active] 331678003883 Transposase IS200 like; Region: Y1_Tnp; cl00848 331678003884 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 331678003885 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 331678003886 NAD(P) binding site [chemical binding]; other site 331678003887 putative active site [active] 331678003888 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331678003889 dimerization interface [polypeptide binding]; other site 331678003890 putative DNA binding site [nucleotide binding]; other site 331678003891 Transcriptional regulators [Transcription]; Region: MarR; COG1846 331678003892 putative Zn2+ binding site [ion binding]; other site 331678003893 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14456 331678003894 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678003895 FeS/SAM binding site; other site 331678003896 adenylate kinase; Reviewed; Region: adk; PRK00279 331678003897 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 331678003898 AMP-binding site [chemical binding]; other site 331678003899 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 331678003900 Helix-turn-helix domain; Region: HTH_20; pfam12840 331678003901 primosomal protein N' Region: priA; TIGR00595 331678003902 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 331678003903 ATP binding site [chemical binding]; other site 331678003904 putative Mg++ binding site [ion binding]; other site 331678003905 helicase superfamily c-terminal domain; Region: HELICc; smart00490 331678003906 ATP-binding site [chemical binding]; other site 331678003907 Transposase domain (DUF772); Region: DUF772; pfam05598 331678003908 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 331678003909 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678003910 binding surface 331678003911 TPR repeat; Region: TPR_11; pfam13414 331678003912 TPR motif; other site 331678003913 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678003914 TPR motif; other site 331678003915 binding surface 331678003916 TPR repeat; Region: TPR_11; pfam13414 331678003917 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 331678003918 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 331678003919 Dehydroquinase class II; Region: DHquinase_II; pfam01220 331678003920 trimer interface [polypeptide binding]; other site 331678003921 active site 331678003922 dimer interface [polypeptide binding]; other site 331678003923 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 331678003924 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 331678003925 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 331678003926 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678003927 Walker A motif; other site 331678003928 ATP binding site [chemical binding]; other site 331678003929 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678003930 Walker B motif; other site 331678003931 arginine finger; other site 331678003932 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 331678003933 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 331678003934 active site 331678003935 HslU subunit interaction site [polypeptide binding]; other site 331678003936 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 331678003937 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 331678003938 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 331678003939 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307 331678003940 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14174 331678003941 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 331678003942 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 331678003943 homodimer interface [polypeptide binding]; other site 331678003944 NADP binding site [chemical binding]; other site 331678003945 substrate binding site [chemical binding]; other site 331678003946 DNA repair protein RadA; Provisional; Region: PRK11823 331678003947 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 331678003948 Walker A motif/ATP binding site; other site 331678003949 ATP binding site [chemical binding]; other site 331678003950 Walker B motif; other site 331678003951 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 331678003952 Membrane protein of unknown function; Region: DUF360; pfam04020 331678003953 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 331678003954 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 331678003955 putative NAD(P) binding site [chemical binding]; other site 331678003956 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 331678003957 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 331678003958 Walker A/P-loop; other site 331678003959 ATP binding site [chemical binding]; other site 331678003960 Q-loop/lid; other site 331678003961 ABC transporter signature motif; other site 331678003962 Walker B; other site 331678003963 D-loop; other site 331678003964 H-loop/switch region; other site 331678003965 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 331678003966 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 331678003967 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 331678003968 TM-ABC transporter signature motif; other site 331678003969 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 331678003970 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 331678003971 Cl- selectivity filter; other site 331678003972 Cl- binding residues [ion binding]; other site 331678003973 pore gating glutamate residue; other site 331678003974 dimer interface [polypeptide binding]; other site 331678003975 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 331678003976 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 331678003977 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 331678003978 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 331678003979 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 331678003980 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678003981 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 331678003982 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 331678003983 substrate binding pocket [chemical binding]; other site 331678003984 chain length determination region; other site 331678003985 substrate-Mg2+ binding site; other site 331678003986 catalytic residues [active] 331678003987 aspartate-rich region 1; other site 331678003988 active site lid residues [active] 331678003989 aspartate-rich region 2; other site 331678003990 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 331678003991 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 331678003992 dephospho-CoA kinase; Provisional; Region: coaE; PRK14731 331678003993 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 331678003994 CoA-binding site [chemical binding]; other site 331678003995 ATP-binding [chemical binding]; other site 331678003996 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 331678003997 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 331678003998 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 331678003999 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 331678004000 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 331678004001 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 331678004002 putative RNA binding site [nucleotide binding]; other site 331678004003 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678004004 S-adenosylmethionine binding site [chemical binding]; other site 331678004005 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; pfam06941 331678004006 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 331678004007 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 331678004008 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 331678004009 catalytic residues [active] 331678004010 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 331678004011 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 331678004012 Protein of unknown function (DUF1318); Region: DUF1318; pfam07027 331678004013 Dicarboxylate transport; Region: DctA-YdbH; cl14674 331678004014 Dicarboxylate transport; Region: DctA-YdbH; cl14674 331678004015 Dicarboxylate transport; Region: DctA-YdbH; pfam11739 331678004016 DinB superfamily; Region: DinB_2; pfam12867 331678004017 flavoprotein, HI0933 family; Region: TIGR00275 331678004018 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 331678004019 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 331678004020 HlyD family secretion protein; Region: HlyD_3; pfam13437 331678004021 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 331678004022 FtsX-like permease family; Region: FtsX; pfam02687 331678004023 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 331678004024 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 331678004025 Walker A/P-loop; other site 331678004026 ATP binding site [chemical binding]; other site 331678004027 Q-loop/lid; other site 331678004028 ABC transporter signature motif; other site 331678004029 Walker B; other site 331678004030 D-loop; other site 331678004031 H-loop/switch region; other site 331678004032 mercuric reductase; Validated; Region: PRK06370 331678004033 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331678004034 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 331678004035 SET domain; Region: SET; pfam00856 331678004036 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 331678004037 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 331678004038 putative active site [active] 331678004039 metal binding site [ion binding]; metal-binding site 331678004040 KWG Leptospira; Region: KWG; pfam07656 331678004041 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 331678004042 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 331678004043 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323 331678004044 gating phenylalanine in ion channel; other site 331678004045 OsmC-like protein; Region: OsmC; pfam02566 331678004046 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 331678004047 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 331678004048 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 331678004049 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 331678004050 putative dimer interface [polypeptide binding]; other site 331678004051 active site pocket [active] 331678004052 putative cataytic base [active] 331678004053 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 331678004054 homotrimer interface [polypeptide binding]; other site 331678004055 Walker A motif; other site 331678004056 GTP binding site [chemical binding]; other site 331678004057 Walker B motif; other site 331678004058 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 331678004059 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 331678004060 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 331678004061 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 331678004062 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 331678004063 DinB superfamily; Region: DinB_2; pfam12867 331678004064 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 331678004065 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 331678004066 Sel1-like repeats; Region: SEL1; smart00671 331678004067 Sel1-like repeats; Region: SEL1; smart00671 331678004068 Sel1-like repeats; Region: SEL1; smart00671 331678004069 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 331678004070 Sel1-like repeats; Region: SEL1; smart00671 331678004071 Sel1-like repeats; Region: SEL1; smart00671 331678004072 Sel1-like repeats; Region: SEL1; smart00671 331678004073 Sel1-like repeats; Region: SEL1; smart00671 331678004074 Sel1-like repeats; Region: SEL1; smart00671 331678004075 Sel1-like repeats; Region: SEL1; smart00671 331678004076 UbiA prenyltransferase family; Region: UbiA; pfam01040 331678004077 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 331678004078 Transposase IS200 like; Region: Y1_Tnp; cl00848 331678004079 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 331678004080 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 331678004081 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 331678004082 Methyltransferase domain; Region: Methyltransf_23; pfam13489 331678004083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678004084 S-adenosylmethionine binding site [chemical binding]; other site 331678004085 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 331678004086 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 331678004087 NADP binding site [chemical binding]; other site 331678004088 dimer interface [polypeptide binding]; other site 331678004089 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 331678004090 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 331678004091 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 331678004092 Walker A/P-loop; other site 331678004093 ATP binding site [chemical binding]; other site 331678004094 Q-loop/lid; other site 331678004095 ABC transporter signature motif; other site 331678004096 Walker B; other site 331678004097 D-loop; other site 331678004098 H-loop/switch region; other site 331678004099 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 331678004100 dimer interface [polypeptide binding]; other site 331678004101 putative PBP binding regions; other site 331678004102 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 331678004103 ABC-ATPase subunit interface; other site 331678004104 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 331678004105 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 331678004106 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331678004107 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678004108 homodimer interface [polypeptide binding]; other site 331678004109 catalytic residue [active] 331678004110 cobyric acid synthase; Provisional; Region: PRK00784 331678004111 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 331678004112 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 331678004113 catalytic triad [active] 331678004114 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 331678004115 putative FMN binding site [chemical binding]; other site 331678004116 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 331678004117 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 331678004118 intersubunit interface [polypeptide binding]; other site 331678004119 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 331678004120 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 331678004121 N-terminal plug; other site 331678004122 ligand-binding site [chemical binding]; other site 331678004123 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 331678004124 putative hydrophobic ligand binding site [chemical binding]; other site 331678004125 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678004126 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 331678004127 nudix motif; other site 331678004128 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 331678004129 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 331678004130 cobalamin binding residues [chemical binding]; other site 331678004131 putative BtuC binding residues; other site 331678004132 dimer interface [polypeptide binding]; other site 331678004133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331678004134 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331678004135 putative substrate translocation pore; other site 331678004136 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 331678004137 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 331678004138 active site 331678004139 NTP binding site [chemical binding]; other site 331678004140 metal binding triad [ion binding]; metal-binding site 331678004141 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 331678004142 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 331678004143 Zn2+ binding site [ion binding]; other site 331678004144 Mg2+ binding site [ion binding]; other site 331678004145 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 331678004146 adenylosuccinate lyase; Provisional; Region: PRK07492 331678004147 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 331678004148 tetramer interface [polypeptide binding]; other site 331678004149 active site 331678004150 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 331678004151 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 331678004152 ferredoxin; Validated; Region: PRK07118 331678004153 Putative Fe-S cluster; Region: FeS; cl17515 331678004154 4Fe-4S binding domain; Region: Fer4; pfam00037 331678004155 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 331678004156 SLBB domain; Region: SLBB; pfam10531 331678004157 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 331678004158 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 331678004159 FMN-binding domain; Region: FMN_bind; cl01081 331678004160 electron transport complex RsxE subunit; Provisional; Region: PRK12405 331678004161 electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943 331678004162 Inorganic pyrophosphatase; Region: Pyrophosphatase; pfam00719 331678004163 dimer interface [polypeptide binding]; other site 331678004164 substrate binding site [chemical binding]; other site 331678004165 metal binding sites [ion binding]; metal-binding site 331678004166 Cna protein B-type domain; Region: Cna_B_2; pfam13715 331678004167 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 331678004168 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 331678004169 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 331678004170 Phytase; Region: Phytase; cl17685 331678004171 AAA domain; Region: AAA_13; pfam13166 331678004172 AAA domain; Region: AAA_13; pfam13166 331678004173 Restriction endonuclease; Region: Mrr_cat; pfam04471 331678004174 Beet necrotic yellow vein furovirus-type papain-like endopeptidase; Region: Peptidase_C36; pfam05415 331678004175 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 331678004176 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678004177 Walker A motif; other site 331678004178 ATP binding site [chemical binding]; other site 331678004179 Walker B motif; other site 331678004180 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 331678004181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331678004182 active site 331678004183 phosphorylation site [posttranslational modification] 331678004184 intermolecular recognition site; other site 331678004185 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 331678004186 Caspase domain; Region: Peptidase_C14; pfam00656 331678004187 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 331678004188 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 331678004189 thiS-thiF/thiG interaction site; other site 331678004190 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 331678004191 ThiS interaction site; other site 331678004192 putative active site [active] 331678004193 tetramer interface [polypeptide binding]; other site 331678004194 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 331678004195 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678004196 FeS/SAM binding site; other site 331678004197 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 331678004198 von Willebrand factor type A domain; Region: VWA_2; pfam13519 331678004199 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 331678004200 Family description; Region: UvrD_C_2; pfam13538 331678004201 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 331678004202 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 331678004203 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; pfam09603 331678004204 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; pfam09603 331678004205 putative DNA binding site [nucleotide binding]; other site 331678004206 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 331678004207 putative Zn2+ binding site [ion binding]; other site 331678004208 Methyltransferase domain; Region: Methyltransf_31; pfam13847 331678004209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678004210 S-adenosylmethionine binding site [chemical binding]; other site 331678004211 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 331678004212 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 331678004213 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 331678004214 homodimer interface [polypeptide binding]; other site 331678004215 substrate-cofactor binding pocket; other site 331678004216 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678004217 catalytic residue [active] 331678004218 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 331678004219 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 331678004220 putative ligand binding site [chemical binding]; other site 331678004221 putative NAD binding site [chemical binding]; other site 331678004222 putative catalytic site [active] 331678004223 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 331678004224 L-serine binding site [chemical binding]; other site 331678004225 ACT domain interface; other site 331678004226 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 331678004227 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331678004228 motif II; other site 331678004229 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 331678004230 putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574 331678004231 Family description; Region: DsbD_2; pfam13386 331678004232 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 331678004233 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 331678004234 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 331678004235 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 331678004236 metal-binding site [ion binding] 331678004237 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 331678004238 Soluble P-type ATPase [General function prediction only]; Region: COG4087 331678004239 YtkA-like; Region: YtkA; pfam13115 331678004240 FixH; Region: FixH; pfam05751 331678004241 YtkA-like; Region: YtkA; pfam13115 331678004242 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678004243 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 331678004244 4Fe-4S binding domain; Region: Fer4_5; pfam12801 331678004245 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 331678004246 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 331678004247 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 331678004248 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 331678004249 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 331678004250 Low-spin heme binding site [chemical binding]; other site 331678004251 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 331678004252 D-pathway; other site 331678004253 Putative water exit pathway; other site 331678004254 Binuclear center (active site) [active] 331678004255 K-pathway; other site 331678004256 Putative proton exit pathway; other site 331678004257 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 331678004258 active site 331678004259 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 331678004260 homodecamer interface [polypeptide binding]; other site 331678004261 GTP cyclohydrolase I; Provisional; Region: PLN03044 331678004262 active site 331678004263 putative catalytic site residues [active] 331678004264 zinc binding site [ion binding]; other site 331678004265 GTP-CH-I/GFRP interaction surface; other site 331678004266 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 331678004267 Domain of unknown function DUF20; Region: UPF0118; pfam01594 331678004268 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 331678004269 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 331678004270 putative substrate-binding site; other site 331678004271 nickel binding site [ion binding]; other site 331678004272 Ni/Fe-hydrogenase, b-type cytochrome subunit; Region: CytB-hydogenase; TIGR02125 331678004273 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 331678004274 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 331678004275 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 331678004276 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 331678004277 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 331678004278 Domain of unknown function DUF21; Region: DUF21; pfam01595 331678004279 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 331678004280 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 331678004281 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 331678004282 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 331678004283 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 331678004284 hydrogenase 4 subunit D; Validated; Region: PRK06525 331678004285 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 331678004286 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 331678004287 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 331678004288 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 331678004289 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 331678004290 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 331678004291 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 331678004292 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 331678004293 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 331678004294 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 331678004295 NADH dehydrogenase subunit D; Validated; Region: PRK06075 331678004296 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 331678004297 NADH dehydrogenase subunit B; Provisional; Region: PRK14813 331678004298 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 331678004299 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678004300 TPR motif; other site 331678004301 TPR repeat; Region: TPR_11; pfam13414 331678004302 binding surface 331678004303 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678004304 binding surface 331678004305 TPR repeat; Region: TPR_11; pfam13414 331678004306 TPR motif; other site 331678004307 TPR repeat; Region: TPR_11; pfam13414 331678004308 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678004309 binding surface 331678004310 Tetratricopeptide repeat; Region: TPR_16; pfam13432 331678004311 TPR motif; other site 331678004312 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 331678004313 nucleotide binding site/active site [active] 331678004314 HIT family signature motif; other site 331678004315 catalytic residue [active] 331678004316 Methyltransferase domain; Region: Methyltransf_23; pfam13489 331678004317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678004318 S-adenosylmethionine binding site [chemical binding]; other site 331678004319 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 331678004320 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 331678004321 TrkA-N domain; Region: TrkA_N; pfam02254 331678004322 universal stress protein UspE; Provisional; Region: PRK11175 331678004323 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 331678004324 Ligand Binding Site [chemical binding]; other site 331678004325 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 331678004326 Ligand Binding Site [chemical binding]; other site 331678004327 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 331678004328 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 331678004329 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 331678004330 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 331678004331 Soluble P-type ATPase [General function prediction only]; Region: COG4087 331678004332 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 331678004333 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 331678004334 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 331678004335 recombination factor protein RarA; Reviewed; Region: PRK13342 331678004336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678004337 Walker A motif; other site 331678004338 ATP binding site [chemical binding]; other site 331678004339 Walker B motif; other site 331678004340 arginine finger; other site 331678004341 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 331678004342 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 331678004343 Lumazine binding domain; Region: Lum_binding; pfam00677 331678004344 Lumazine binding domain; Region: Lum_binding; pfam00677 331678004345 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 331678004346 dimer interface [polypeptide binding]; other site 331678004347 catalytic triad [active] 331678004348 peroxidatic and resolving cysteines [active] 331678004349 Predicted membrane protein [Function unknown]; Region: COG2259 331678004350 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 331678004351 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 331678004352 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 331678004353 catalytic motif [active] 331678004354 Zn binding site [ion binding]; other site 331678004355 RibD C-terminal domain; Region: RibD_C; cl17279 331678004356 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 331678004357 catalytic motif [active] 331678004358 Zn binding site [ion binding]; other site 331678004359 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 331678004360 Domain of unknown function (DUF814); Region: DUF814; pfam05670 331678004361 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 331678004362 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 331678004363 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 331678004364 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 331678004365 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 331678004366 protein translocase, SecG subunit; Region: secG; TIGR00810 331678004367 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 331678004368 putative active site pocket [active] 331678004369 4-fold oligomerization interface [polypeptide binding]; other site 331678004370 metal binding residues [ion binding]; metal-binding site 331678004371 3-fold/trimer interface [polypeptide binding]; other site 331678004372 phosphodiesterase; Provisional; Region: PRK12704 331678004373 KH domain; Region: KH_1; pfam00013 331678004374 uncharacterized domain HDIG; Region: HDIG; TIGR00277 331678004375 Cell division protein ZapA; Region: ZapA; pfam05164 331678004376 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 331678004377 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 331678004378 putative tRNA-binding site [nucleotide binding]; other site 331678004379 B3/4 domain; Region: B3_4; pfam03483 331678004380 tRNA synthetase B5 domain; Region: B5; smart00874 331678004381 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 331678004382 dimer interface [polypeptide binding]; other site 331678004383 motif 1; other site 331678004384 motif 3; other site 331678004385 motif 2; other site 331678004386 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 331678004387 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 331678004388 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 331678004389 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 331678004390 HlyD family secretion protein; Region: HlyD_3; pfam13437 331678004391 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 331678004392 MarR family; Region: MarR_2; pfam12802 331678004393 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 331678004394 nudix motif; other site 331678004395 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 331678004396 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 331678004397 active site 331678004398 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 331678004399 putative trimer interface [polypeptide binding]; other site 331678004400 putative CoA binding site [chemical binding]; other site 331678004401 S-adenosylmethionine synthetase; Validated; Region: PRK05250 331678004402 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 331678004403 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 331678004404 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 331678004405 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 331678004406 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 331678004407 homotetramer interface [polypeptide binding]; other site 331678004408 ligand binding site [chemical binding]; other site 331678004409 catalytic site [active] 331678004410 NAD binding site [chemical binding]; other site 331678004411 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 331678004412 active site 331678004413 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 331678004414 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 331678004415 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 331678004416 Low molecular weight phosphatase family; Region: LMWPc; cd00115 331678004417 active site 331678004418 Rubrerythrin [Energy production and conversion]; Region: COG1592 331678004419 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 331678004420 binuclear metal center [ion binding]; other site 331678004421 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 331678004422 iron binding site [ion binding]; other site 331678004423 cyclase homology domain; Region: CHD; cd07302 331678004424 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 331678004425 nucleotidyl binding site; other site 331678004426 metal binding site [ion binding]; metal-binding site 331678004427 dimer interface [polypeptide binding]; other site 331678004428 Transcriptional regulators [Transcription]; Region: MarR; COG1846 331678004429 MarR family; Region: MarR; pfam01047 331678004430 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 331678004431 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678004432 FeS/SAM binding site; other site 331678004433 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 331678004434 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 331678004435 Na binding site [ion binding]; other site 331678004436 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 331678004437 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331678004438 Coenzyme A binding pocket [chemical binding]; other site 331678004439 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 331678004440 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 331678004441 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 331678004442 putative efflux protein, MATE family; Region: matE; TIGR00797 331678004443 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 331678004444 Methylamine utilisation protein MauE; Region: MauE; pfam07291 331678004445 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 331678004446 active site residue [active] 331678004447 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 331678004448 trimer interface [polypeptide binding]; other site 331678004449 putative Zn binding site [ion binding]; other site 331678004450 Protein of unknown function DUF45; Region: DUF45; pfam01863 331678004451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331678004452 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331678004453 putative substrate translocation pore; other site 331678004454 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 331678004455 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 331678004456 HlyD family secretion protein; Region: HlyD_3; pfam13437 331678004457 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 331678004458 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 331678004459 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 331678004460 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 331678004461 Walker A/P-loop; other site 331678004462 ATP binding site [chemical binding]; other site 331678004463 Q-loop/lid; other site 331678004464 ABC transporter signature motif; other site 331678004465 Walker B; other site 331678004466 D-loop; other site 331678004467 H-loop/switch region; other site 331678004468 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 331678004469 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 331678004470 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 331678004471 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 331678004472 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 331678004473 metal ion-dependent adhesion site (MIDAS); other site 331678004474 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 331678004475 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 331678004476 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 331678004477 DEAD-like helicases superfamily; Region: DEXDc; smart00487 331678004478 DEAD-like helicases superfamily; Region: DEXDc; smart00487 331678004479 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 331678004480 putative Mg++ binding site [ion binding]; other site 331678004481 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 331678004482 ATP-binding site [chemical binding]; other site 331678004483 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 331678004484 putative homodimer interface [polypeptide binding]; other site 331678004485 putative active site [active] 331678004486 catalytic site [active] 331678004487 Protein of unknown function (DUF511); Region: DUF511; cl01114 331678004488 Restriction endonuclease; Region: Mrr_cat; pfam04471 331678004489 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 331678004490 MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown; Region: MIT_C; cd02685 331678004491 TIGR02687 family protein; Region: TIGR02687 331678004492 PglZ domain; Region: PglZ; pfam08665 331678004493 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 331678004494 Methyltransferase domain; Region: Methyltransf_26; pfam13659 331678004495 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 331678004496 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331678004497 AAA domain; Region: AAA_21; pfam13304 331678004498 Walker A/P-loop; other site 331678004499 ATP binding site [chemical binding]; other site 331678004500 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331678004501 Walker B; other site 331678004502 D-loop; other site 331678004503 H-loop/switch region; other site 331678004504 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 331678004505 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 331678004506 DNA binding domain, excisionase family; Region: excise; TIGR01764 331678004507 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 331678004508 putative active site pocket [active] 331678004509 dimerization interface [polypeptide binding]; other site 331678004510 putative catalytic residue [active] 331678004511 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cd00352 331678004512 active site 331678004513 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 331678004514 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 331678004515 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 331678004516 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 331678004517 catalytic triad [active] 331678004518 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 331678004519 nudix motif; other site 331678004520 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 331678004521 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 331678004522 Mechanosensitive ion channel; Region: MS_channel; pfam00924 331678004523 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 331678004524 dimerization interface [polypeptide binding]; other site 331678004525 PAS domain; Region: PAS; smart00091 331678004526 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 331678004527 putative active site [active] 331678004528 heme pocket [chemical binding]; other site 331678004529 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331678004530 dimer interface [polypeptide binding]; other site 331678004531 phosphorylation site [posttranslational modification] 331678004532 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331678004533 ATP binding site [chemical binding]; other site 331678004534 Mg2+ binding site [ion binding]; other site 331678004535 G-X-G motif; other site 331678004536 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 331678004537 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331678004538 active site 331678004539 phosphorylation site [posttranslational modification] 331678004540 intermolecular recognition site; other site 331678004541 dimerization interface [polypeptide binding]; other site 331678004542 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 331678004543 DNA binding site [nucleotide binding] 331678004544 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 331678004545 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 331678004546 Walker A/P-loop; other site 331678004547 ATP binding site [chemical binding]; other site 331678004548 Q-loop/lid; other site 331678004549 ABC transporter signature motif; other site 331678004550 Walker B; other site 331678004551 D-loop; other site 331678004552 H-loop/switch region; other site 331678004553 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 331678004554 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 331678004555 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 331678004556 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 331678004557 ATP binding site [chemical binding]; other site 331678004558 putative Mg++ binding site [ion binding]; other site 331678004559 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 331678004560 nucleotide binding region [chemical binding]; other site 331678004561 ATP-binding site [chemical binding]; other site 331678004562 TRCF domain; Region: TRCF; pfam03461 331678004563 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 331678004564 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 331678004565 catalytic loop [active] 331678004566 iron binding site [ion binding]; other site 331678004567 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 331678004568 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 331678004569 catalytic loop [active] 331678004570 iron binding site [ion binding]; other site 331678004571 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 331678004572 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 331678004573 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 331678004574 hexamer interface [polypeptide binding]; other site 331678004575 ligand binding site [chemical binding]; other site 331678004576 putative active site [active] 331678004577 NAD(P) binding site [chemical binding]; other site 331678004578 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 331678004579 carotene isomerase; Region: carot_isom; TIGR02730 331678004580 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 331678004581 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 331678004582 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 331678004583 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 331678004584 DNA binding residues [nucleotide binding] 331678004585 Putative zinc-finger; Region: zf-HC2; pfam13490 331678004586 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331678004587 dimerization interface [polypeptide binding]; other site 331678004588 putative DNA binding site [nucleotide binding]; other site 331678004589 putative Zn2+ binding site [ion binding]; other site 331678004590 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 331678004591 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 331678004592 putative dimer interface [polypeptide binding]; other site 331678004593 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 331678004594 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 331678004595 nucleotide binding site [chemical binding]; other site 331678004596 NEF interaction site [polypeptide binding]; other site 331678004597 SBD interface [polypeptide binding]; other site 331678004598 Photosystem P840 reaction centre protein PscD; Region: RC-P840_PscD; pfam10657 331678004599 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 331678004600 Tetratricopeptide repeat; Region: TPR_6; pfam13174 331678004601 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 331678004602 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 331678004603 ligand binding site [chemical binding]; other site 331678004604 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 331678004605 TolB amino-terminal domain; Region: TolB_N; pfam04052 331678004606 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 331678004607 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 331678004608 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 331678004609 TonB C terminal; Region: TonB_2; pfam13103 331678004610 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 331678004611 TolR protein; Region: tolR; TIGR02801 331678004612 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 331678004613 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 331678004614 Integral membrane protein DUF92; Region: DUF92; pfam01940 331678004615 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 331678004616 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 331678004617 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 331678004618 PYR/PP interface [polypeptide binding]; other site 331678004619 dimer interface [polypeptide binding]; other site 331678004620 TPP binding site [chemical binding]; other site 331678004621 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 331678004622 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 331678004623 TPP-binding site [chemical binding]; other site 331678004624 dimer interface [polypeptide binding]; other site 331678004625 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 331678004626 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 331678004627 putative valine binding site [chemical binding]; other site 331678004628 dimer interface [polypeptide binding]; other site 331678004629 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 331678004630 ketol-acid reductoisomerase; Provisional; Region: PRK05479 331678004631 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 331678004632 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 331678004633 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 331678004634 tartrate dehydrogenase; Region: TTC; TIGR02089 331678004635 2-isopropylmalate synthase; Validated; Region: PRK00915 331678004636 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 331678004637 active site 331678004638 catalytic residues [active] 331678004639 metal binding site [ion binding]; metal-binding site 331678004640 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 331678004641 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 331678004642 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 331678004643 substrate binding site [chemical binding]; other site 331678004644 ligand binding site [chemical binding]; other site 331678004645 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 331678004646 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 331678004647 substrate binding site [chemical binding]; other site 331678004648 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 331678004649 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 331678004650 active site 331678004651 catalytic residues [active] 331678004652 metal binding site [ion binding]; metal-binding site 331678004653 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 331678004654 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 331678004655 serpin-like protein; Provisional; Region: PHA02660 331678004656 reactive center loop; other site 331678004657 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 331678004658 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 331678004659 active site 331678004660 catalytic site [active] 331678004661 substrate binding site [chemical binding]; other site 331678004662 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 331678004663 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 331678004664 Peptidase family M48; Region: Peptidase_M48; pfam01435 331678004665 Yeast cortical protein KAR9; Region: KAR9; pfam08580 331678004666 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 331678004667 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 331678004668 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 331678004669 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 331678004670 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 331678004671 putative active site; other site 331678004672 catalytic triad [active] 331678004673 putative dimer interface [polypeptide binding]; other site 331678004674 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 331678004675 UbiA prenyltransferase family; Region: UbiA; pfam01040 331678004676 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 331678004677 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 331678004678 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 331678004679 4-aminobutyrate aminotransferase; Provisional; Region: PRK08360 331678004680 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 331678004681 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 331678004682 substrate binding site [chemical binding]; other site 331678004683 glutamase interaction surface [polypeptide binding]; other site 331678004684 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 331678004685 Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350 331678004686 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 331678004687 iron-sulfur cluster [ion binding]; other site 331678004688 [2Fe-2S] cluster binding site [ion binding]; other site 331678004689 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 331678004690 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 331678004691 oligomer interface [polypeptide binding]; other site 331678004692 metal binding site [ion binding]; metal-binding site 331678004693 metal binding site [ion binding]; metal-binding site 331678004694 Cl binding site [ion binding]; other site 331678004695 aspartate ring; other site 331678004696 basic sphincter; other site 331678004697 putative hydrophobic gate; other site 331678004698 periplasmic entrance; other site 331678004699 Domain of unknown function (DUF389); Region: DUF389; cl00781 331678004700 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 331678004701 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 331678004702 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 331678004703 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 331678004704 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 331678004705 active site 331678004706 purine riboside binding site [chemical binding]; other site 331678004707 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 331678004708 active site 331678004709 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 331678004710 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 331678004711 active site 331678004712 catalytic residues [active] 331678004713 metal binding site [ion binding]; metal-binding site 331678004714 Nif-specific regulatory protein; Region: nifA; TIGR01817 331678004715 GAF domain; Region: GAF; pfam01590 331678004716 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678004717 Walker A motif; other site 331678004718 ATP binding site [chemical binding]; other site 331678004719 Walker B motif; other site 331678004720 arginine finger; other site 331678004721 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 331678004722 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 331678004723 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 331678004724 nitrogenase reductase; Reviewed; Region: nifH; PRK13235 331678004725 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 331678004726 Nucleotide-binding sites [chemical binding]; other site 331678004727 Walker A motif; other site 331678004728 Switch I region of nucleotide binding site; other site 331678004729 Fe4S4 binding sites [ion binding]; other site 331678004730 Switch II region of nucleotide binding site; other site 331678004731 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 331678004732 Nitrogen regulatory protein P-II; Region: P-II; smart00938 331678004733 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 331678004734 Nitrogen regulatory protein P-II; Region: P-II; smart00938 331678004735 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 331678004736 MoFe protein alpha/beta subunit interactions; other site 331678004737 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 331678004738 Alpha subunit P cluster binding residues; other site 331678004739 FeMoco binding residues [chemical binding]; other site 331678004740 MoFe protein alpha subunit/Fe protein contacts; other site 331678004741 MoFe protein dimer/ dimer interactions; other site 331678004742 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 331678004743 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 331678004744 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 331678004745 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 331678004746 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 331678004747 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 331678004748 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 331678004749 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678004750 FeS/SAM binding site; other site 331678004751 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 331678004752 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 331678004753 dimer interface [polypeptide binding]; other site 331678004754 [2Fe-2S] cluster binding site [ion binding]; other site 331678004755 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 331678004756 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331678004757 dimer interface [polypeptide binding]; other site 331678004758 phosphorylation site [posttranslational modification] 331678004759 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331678004760 ATP binding site [chemical binding]; other site 331678004761 Mg2+ binding site [ion binding]; other site 331678004762 G-X-G motif; other site 331678004763 Response regulator receiver domain; Region: Response_reg; pfam00072 331678004764 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331678004765 active site 331678004766 phosphorylation site [posttranslational modification] 331678004767 intermolecular recognition site; other site 331678004768 dimerization interface [polypeptide binding]; other site 331678004769 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 331678004770 dimerization interface [polypeptide binding]; other site 331678004771 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 331678004772 ATP binding site [chemical binding]; other site 331678004773 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 331678004774 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 331678004775 HupF/HypC family; Region: HupF_HypC; pfam01455 331678004776 Acylphosphatase; Region: Acylphosphatase; pfam00708 331678004777 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 331678004778 HypF finger; Region: zf-HYPF; pfam07503 331678004779 HypF finger; Region: zf-HYPF; pfam07503 331678004780 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 331678004781 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 331678004782 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 331678004783 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 331678004784 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 331678004785 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 331678004786 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 331678004787 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 331678004788 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 331678004789 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 331678004790 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 331678004791 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 331678004792 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 331678004793 Na binding site [ion binding]; other site 331678004794 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14671 331678004795 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 331678004796 GIY-YIG motif/motif A; other site 331678004797 active site 331678004798 catalytic site [active] 331678004799 putative DNA binding site [nucleotide binding]; other site 331678004800 metal binding site [ion binding]; metal-binding site 331678004801 UvrB/uvrC motif; Region: UVR; pfam02151 331678004802 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 331678004803 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 331678004804 DNA binding site [nucleotide binding] 331678004805 TPR repeat; Region: TPR_11; pfam13414 331678004806 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678004807 binding surface 331678004808 TPR motif; other site 331678004809 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678004810 binding surface 331678004811 TPR repeat; Region: TPR_11; pfam13414 331678004812 TPR motif; other site 331678004813 TPR repeat; Region: TPR_11; pfam13414 331678004814 TPR repeat; Region: TPR_11; pfam13414 331678004815 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678004816 binding surface 331678004817 TPR motif; other site 331678004818 TPR repeat; Region: TPR_11; pfam13414 331678004819 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678004820 binding surface 331678004821 TPR motif; other site 331678004822 TPR repeat; Region: TPR_11; pfam13414 331678004823 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678004824 binding surface 331678004825 TPR motif; other site 331678004826 TPR repeat; Region: TPR_11; pfam13414 331678004827 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 331678004828 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 331678004829 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 331678004830 shikimate binding site; other site 331678004831 NAD(P) binding site [chemical binding]; other site 331678004832 lipoprotein signal peptidase; Provisional; Region: PRK14787 331678004833 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 331678004834 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 331678004835 active site 331678004836 Tetratricopeptide repeat; Region: TPR_12; pfam13424 331678004837 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 331678004838 active site 331678004839 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 331678004840 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 331678004841 catalytic residue [active] 331678004842 alanine aminotransferase; Validated; Region: PRK08363 331678004843 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 331678004844 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678004845 homodimer interface [polypeptide binding]; other site 331678004846 catalytic residue [active] 331678004847 purine nucleoside phosphorylase; Provisional; Region: PRK08202 331678004848 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 331678004849 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 331678004850 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 331678004851 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 331678004852 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 331678004853 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331678004854 Walker A/P-loop; other site 331678004855 ATP binding site [chemical binding]; other site 331678004856 Q-loop/lid; other site 331678004857 ABC transporter signature motif; other site 331678004858 Walker B; other site 331678004859 D-loop; other site 331678004860 H-loop/switch region; other site 331678004861 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 331678004862 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 331678004863 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331678004864 Walker A/P-loop; other site 331678004865 ATP binding site [chemical binding]; other site 331678004866 Q-loop/lid; other site 331678004867 ABC transporter signature motif; other site 331678004868 Walker B; other site 331678004869 D-loop; other site 331678004870 H-loop/switch region; other site 331678004871 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 331678004872 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 331678004873 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 331678004874 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 331678004875 putative active site [active] 331678004876 putative substrate binding site [chemical binding]; other site 331678004877 putative cosubstrate binding site; other site 331678004878 catalytic site [active] 331678004879 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 331678004880 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 331678004881 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 331678004882 active site 331678004883 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 331678004884 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 331678004885 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 331678004886 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 331678004887 Ligand binding site; other site 331678004888 Putative Catalytic site; other site 331678004889 DXD motif; other site 331678004890 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 331678004891 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 331678004892 DHH family; Region: DHH; pfam01368 331678004893 DHHA1 domain; Region: DHHA1; pfam02272 331678004894 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 331678004895 AMP binding site [chemical binding]; other site 331678004896 metal binding site [ion binding]; metal-binding site 331678004897 active site 331678004898 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 331678004899 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 331678004900 putative active site [active] 331678004901 metal binding site [ion binding]; metal-binding site 331678004902 homodimer binding site [polypeptide binding]; other site 331678004903 Pirin-related protein [General function prediction only]; Region: COG1741 331678004904 Pirin; Region: Pirin; pfam02678 331678004905 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 331678004906 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 331678004907 quinolinate synthetase; Provisional; Region: PRK09375 331678004908 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 331678004909 oligomerisation interface [polypeptide binding]; other site 331678004910 mobile loop; other site 331678004911 roof hairpin; other site 331678004912 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 331678004913 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 331678004914 rod shape-determining protein MreC; Provisional; Region: PRK13922 331678004915 rod shape-determining protein MreC; Region: MreC; pfam04085 331678004916 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 331678004917 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 331678004918 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 331678004919 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 331678004920 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 331678004921 FAD binding domain; Region: FAD_binding_4; pfam01565 331678004922 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 331678004923 SmpB-tmRNA interface; other site 331678004924 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 331678004925 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 331678004926 active site 331678004927 HIGH motif; other site 331678004928 dimer interface [polypeptide binding]; other site 331678004929 KMSKS motif; other site 331678004930 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 331678004931 RNA binding surface [nucleotide binding]; other site 331678004932 pyruvoyl-dependent arginine decarboxylase; Reviewed; Region: PRK01285 331678004933 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 331678004934 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 331678004935 Domain of unknown function (DUF368); Region: DUF368; pfam04018 331678004936 L-aspartate oxidase; Provisional; Region: PRK09077 331678004937 L-aspartate oxidase; Provisional; Region: PRK06175 331678004938 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 331678004939 NAD synthetase; Provisional; Region: PRK13980 331678004940 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 331678004941 homodimer interface [polypeptide binding]; other site 331678004942 NAD binding pocket [chemical binding]; other site 331678004943 ATP binding pocket [chemical binding]; other site 331678004944 Mg binding site [ion binding]; other site 331678004945 active-site loop [active] 331678004946 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 331678004947 Peptidase family M23; Region: Peptidase_M23; pfam01551 331678004948 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 331678004949 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 331678004950 hinge; other site 331678004951 active site 331678004952 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 331678004953 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 331678004954 substrate binding site [chemical binding]; other site 331678004955 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 331678004956 substrate binding site [chemical binding]; other site 331678004957 ligand binding site [chemical binding]; other site 331678004958 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 331678004959 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 331678004960 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 331678004961 histidinol dehydrogenase; Region: hisD; TIGR00069 331678004962 NAD binding site [chemical binding]; other site 331678004963 dimerization interface [polypeptide binding]; other site 331678004964 product binding site; other site 331678004965 substrate binding site [chemical binding]; other site 331678004966 zinc binding site [ion binding]; other site 331678004967 catalytic residues [active] 331678004968 rod shape-determining protein MreB; Provisional; Region: PRK13930 331678004969 MreB and similar proteins; Region: MreB_like; cd10225 331678004970 nucleotide binding site [chemical binding]; other site 331678004971 Mg binding site [ion binding]; other site 331678004972 putative protofilament interaction site [polypeptide binding]; other site 331678004973 RodZ interaction site [polypeptide binding]; other site 331678004974 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 331678004975 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 331678004976 S-adenosylmethionine synthetase (AdoMet synthetase); Region: AdoMet_Synthase; pfam01941 331678004977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331678004978 putative substrate translocation pore; other site 331678004979 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 331678004980 Uncharacterized conserved protein [Function unknown]; Region: COG0432 331678004981 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 331678004982 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 331678004983 TPP-binding site; other site 331678004984 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 331678004985 PYR/PP interface [polypeptide binding]; other site 331678004986 dimer interface [polypeptide binding]; other site 331678004987 TPP binding site [chemical binding]; other site 331678004988 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 331678004989 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 331678004990 tetramer interfaces [polypeptide binding]; other site 331678004991 binuclear metal-binding site [ion binding]; other site 331678004992 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 331678004993 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 331678004994 MutS domain III; Region: MutS_III; pfam05192 331678004995 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 331678004996 Walker A/P-loop; other site 331678004997 ATP binding site [chemical binding]; other site 331678004998 Q-loop/lid; other site 331678004999 ABC transporter signature motif; other site 331678005000 Walker B; other site 331678005001 D-loop; other site 331678005002 H-loop/switch region; other site 331678005003 Smr domain; Region: Smr; pfam01713 331678005004 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 331678005005 Flagellin N-methylase; Region: FliB; pfam03692 331678005006 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 331678005007 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 331678005008 tricarballylate utilization protein B; Provisional; Region: PRK15033 331678005009 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 331678005010 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 331678005011 4Fe-4S binding domain; Region: Fer4; cl02805 331678005012 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 331678005013 adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854 331678005014 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 331678005015 adenosine phosphosulphate reductase, beta subunit; Region: aprB; TIGR02060 331678005016 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 331678005017 Adenosine-5'-phosphosulfate reductase beta subunit; Region: APS-reductase_C; pfam12139 331678005018 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 331678005019 ATP-sulfurylase; Region: ATPS; cd00517 331678005020 active site 331678005021 HXXH motif; other site 331678005022 flexible loop; other site 331678005023 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 331678005024 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 331678005025 diphthine synthase; Region: dph5; TIGR00522 331678005026 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 331678005027 active site 331678005028 SAM binding site [chemical binding]; other site 331678005029 homodimer interface [polypeptide binding]; other site 331678005030 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 331678005031 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 331678005032 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 331678005033 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 331678005034 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 331678005035 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 331678005036 4Fe-4S binding domain; Region: Fer4; cl02805 331678005037 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 331678005038 Cysteine-rich domain; Region: CCG; pfam02754 331678005039 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 331678005040 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 331678005041 DsrH like protein; Region: DsrH; pfam04077 331678005042 sulfur relay protein TusC/DsrF; Region: sulf_tusC_dsrF; TIGR03010 331678005043 sulfur relay protein TusD/DsrE; Region: sulf_tusD_dsrE; TIGR03012 331678005044 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 331678005045 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 331678005046 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 331678005047 sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066 331678005048 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 331678005049 4Fe-4S binding domain; Region: Fer4; pfam00037 331678005050 sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064 331678005051 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 331678005052 DsrC like protein; Region: DsrC; pfam04358 331678005053 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 331678005054 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 331678005055 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 331678005056 catalytic triad [active] 331678005057 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 331678005058 CPxP motif; other site 331678005059 Predicted membrane protein [Function unknown]; Region: COG2855 331678005060 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 331678005061 active site residue [active] 331678005062 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 331678005063 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 331678005064 molybdopterin cofactor binding site; other site 331678005065 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 331678005066 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 331678005067 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 331678005068 putative molybdopterin cofactor binding site; other site 331678005069 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 331678005070 4Fe-4S binding domain; Region: Fer4; cl02805 331678005071 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 331678005072 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 331678005073 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 331678005074 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 331678005075 active site 331678005076 hydrophilic channel; other site 331678005077 dimerization interface [polypeptide binding]; other site 331678005078 catalytic residues [active] 331678005079 active site lid [active] 331678005080 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 331678005081 active site 331678005082 dimerization interface [polypeptide binding]; other site 331678005083 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 331678005084 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 331678005085 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 331678005086 active site 331678005087 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 331678005088 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 331678005089 Permease; Region: Permease; pfam02405 331678005090 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 331678005091 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 331678005092 Walker A/P-loop; other site 331678005093 ATP binding site [chemical binding]; other site 331678005094 Q-loop/lid; other site 331678005095 ABC transporter signature motif; other site 331678005096 Walker B; other site 331678005097 D-loop; other site 331678005098 H-loop/switch region; other site 331678005099 mce related protein; Region: MCE; pfam02470 331678005100 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 331678005101 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 331678005102 Beta-lactamase; Region: Beta-lactamase; pfam00144 331678005103 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 331678005104 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 331678005105 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 331678005106 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 331678005107 iron-sulfur cluster [ion binding]; other site 331678005108 [2Fe-2S] cluster binding site [ion binding]; other site 331678005109 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 331678005110 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 331678005111 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 331678005112 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 331678005113 purine monophosphate binding site [chemical binding]; other site 331678005114 dimer interface [polypeptide binding]; other site 331678005115 putative catalytic residues [active] 331678005116 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 331678005117 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 331678005118 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 331678005119 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 331678005120 active site 331678005121 substrate binding site [chemical binding]; other site 331678005122 cosubstrate binding site; other site 331678005123 catalytic site [active] 331678005124 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 331678005125 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 331678005126 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 331678005127 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 331678005128 Ligand binding site; other site 331678005129 Putative Catalytic site; other site 331678005130 DXD motif; other site 331678005131 endonuclease IV; Provisional; Region: PRK01060 331678005132 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 331678005133 AP (apurinic/apyrimidinic) site pocket; other site 331678005134 DNA interaction; other site 331678005135 Metal-binding active site; metal-binding site 331678005136 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 331678005137 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 331678005138 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 331678005139 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 331678005140 active site 331678005141 tetramer interface [polypeptide binding]; other site 331678005142 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 331678005143 active site 331678005144 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 331678005145 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 331678005146 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 331678005147 active site 331678005148 HIGH motif; other site 331678005149 nucleotide binding site [chemical binding]; other site 331678005150 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 331678005151 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 331678005152 active site 331678005153 KMSKS motif; other site 331678005154 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 331678005155 tRNA binding surface [nucleotide binding]; other site 331678005156 anticodon binding site; other site 331678005157 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 331678005158 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 331678005159 NAD binding site [chemical binding]; other site 331678005160 substrate binding site [chemical binding]; other site 331678005161 homodimer interface [polypeptide binding]; other site 331678005162 active site 331678005163 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 331678005164 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 331678005165 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 331678005166 NADP binding site [chemical binding]; other site 331678005167 active site 331678005168 putative substrate binding site [chemical binding]; other site 331678005169 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 331678005170 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 331678005171 four helix bundle protein; Region: TIGR02436 331678005172 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 331678005173 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 331678005174 substrate binding site; other site 331678005175 tetramer interface; other site 331678005176 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 331678005177 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 331678005178 active site 331678005179 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 331678005180 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 331678005181 glutaminase active site [active] 331678005182 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 331678005183 dimer interface [polypeptide binding]; other site 331678005184 active site 331678005185 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 331678005186 dimer interface [polypeptide binding]; other site 331678005187 active site 331678005188 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 331678005189 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 331678005190 Substrate binding site; other site 331678005191 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 331678005192 AAA domain; Region: AAA_14; pfam13173 331678005193 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 331678005194 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 331678005195 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 331678005196 active site 331678005197 substrate binding site [chemical binding]; other site 331678005198 metal binding site [ion binding]; metal-binding site 331678005199 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 331678005200 oligomeric interface; other site 331678005201 putative active site [active] 331678005202 homodimer interface [polypeptide binding]; other site 331678005203 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 331678005204 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 331678005205 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 331678005206 four helix bundle protein; Region: TIGR02436 331678005207 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 331678005208 AAA domain; Region: AAA_33; pfam13671 331678005209 ligand-binding site [chemical binding]; other site 331678005210 Uncharacterized conserved protein [Function unknown]; Region: COG1434 331678005211 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 331678005212 putative active site [active] 331678005213 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 331678005214 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 331678005215 NAD binding site [chemical binding]; other site 331678005216 substrate binding site [chemical binding]; other site 331678005217 homodimer interface [polypeptide binding]; other site 331678005218 active site 331678005219 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 331678005220 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 331678005221 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 331678005222 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 331678005223 substrate binding site; other site 331678005224 tetramer interface; other site 331678005225 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678005226 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 331678005227 NAD(P) binding site [chemical binding]; other site 331678005228 active site 331678005229 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 331678005230 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 331678005231 NAD binding site [chemical binding]; other site 331678005232 substrate binding site [chemical binding]; other site 331678005233 homodimer interface [polypeptide binding]; other site 331678005234 active site 331678005235 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 331678005236 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 331678005237 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 331678005238 substrate binding site; other site 331678005239 tetramer interface; other site 331678005240 Transposase domain (DUF772); Region: DUF772; pfam05598 331678005241 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 331678005242 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 331678005243 Transposase; Region: DDE_Tnp_ISL3; pfam01610 331678005244 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 331678005245 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 331678005246 active site 331678005247 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 331678005248 GDP-Fucose binding site [chemical binding]; other site 331678005249 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 331678005250 active site 331678005251 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678005252 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 331678005253 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 331678005254 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678005255 FeS/SAM binding site; other site 331678005256 O-Antigen ligase; Region: Wzy_C; pfam04932 331678005257 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 331678005258 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 331678005259 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 331678005260 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 331678005261 inhibitor-cofactor binding pocket; inhibition site 331678005262 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678005263 catalytic residue [active] 331678005264 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 331678005265 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 331678005266 NADP binding site [chemical binding]; other site 331678005267 active site 331678005268 putative substrate binding site [chemical binding]; other site 331678005269 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 331678005270 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 331678005271 NADP-binding site; other site 331678005272 homotetramer interface [polypeptide binding]; other site 331678005273 substrate binding site [chemical binding]; other site 331678005274 homodimer interface [polypeptide binding]; other site 331678005275 active site 331678005276 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 331678005277 four helix bundle protein; Region: TIGR02436 331678005278 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 331678005279 YcfA-like protein; Region: YcfA; pfam07927 331678005280 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 331678005281 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 331678005282 putative active site [active] 331678005283 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 331678005284 four helix bundle protein; Region: TIGR02436 331678005285 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 331678005286 GIY-YIG motif/motif A; other site 331678005287 putative active site [active] 331678005288 putative metal binding site [ion binding]; other site 331678005289 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 331678005290 YcfA-like protein; Region: YcfA; cl00752 331678005291 Uncharacterized conserved protein [Function unknown]; Region: COG2361 331678005292 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 331678005293 active site 331678005294 NTP binding site [chemical binding]; other site 331678005295 metal binding triad [ion binding]; metal-binding site 331678005296 antibiotic binding site [chemical binding]; other site 331678005297 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 331678005298 four helix bundle protein; Region: TIGR02436 331678005299 Protein of unknown function (DUF2281); Region: DUF2281; pfam10047 331678005300 YcfA-like protein; Region: YcfA; pfam07927 331678005301 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 331678005302 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 331678005303 putative active site [active] 331678005304 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 331678005305 Uncharacterized conserved protein [Function unknown]; Region: COG2361 331678005306 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 331678005307 active site 331678005308 NTP binding site [chemical binding]; other site 331678005309 metal binding triad [ion binding]; metal-binding site 331678005310 antibiotic binding site [chemical binding]; other site 331678005311 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 331678005312 four helix bundle protein; Region: TIGR02436 331678005313 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 331678005314 putative active site [active] 331678005315 homotetrameric interface [polypeptide binding]; other site 331678005316 metal binding site [ion binding]; metal-binding site 331678005317 Protein of unknown function (DUF2281); Region: DUF2281; pfam10047 331678005318 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 331678005319 oligomeric interface; other site 331678005320 putative active site [active] 331678005321 homodimer interface [polypeptide binding]; other site 331678005322 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 331678005323 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678005324 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 331678005325 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 331678005326 Protein of unknown function DUF86; Region: DUF86; pfam01934 331678005327 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 331678005328 active site 331678005329 NTP binding site [chemical binding]; other site 331678005330 metal binding triad [ion binding]; metal-binding site 331678005331 antibiotic binding site [chemical binding]; other site 331678005332 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 331678005333 four helix bundle protein; Region: TIGR02436 331678005334 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 331678005335 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 331678005336 Mg++ binding site [ion binding]; other site 331678005337 putative catalytic motif [active] 331678005338 substrate binding site [chemical binding]; other site 331678005339 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912 331678005340 Mg++ binding site [ion binding]; other site 331678005341 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 331678005342 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 331678005343 Chain length determinant protein; Region: Wzz; pfam02706 331678005344 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 331678005345 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 331678005346 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 331678005347 Nucleotide binding site [chemical binding]; other site 331678005348 DTAP/Switch II; other site 331678005349 Switch I; other site 331678005350 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 331678005351 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 331678005352 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 331678005353 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 331678005354 active site 331678005355 catalytic site [active] 331678005356 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 331678005357 GIY-YIG motif/motif A; other site 331678005358 putative active site [active] 331678005359 putative metal binding site [ion binding]; other site 331678005360 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 331678005361 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 331678005362 intrachain domain interface; other site 331678005363 interchain domain interface [polypeptide binding]; other site 331678005364 heme bH binding site [chemical binding]; other site 331678005365 Qi binding site; other site 331678005366 heme bL binding site [chemical binding]; other site 331678005367 Qo binding site; other site 331678005368 interchain domain interface [polypeptide binding]; other site 331678005369 intrachain domain interface; other site 331678005370 Qi binding site; other site 331678005371 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 331678005372 Qo binding site; other site 331678005373 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 331678005374 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 331678005375 iron-sulfur cluster [ion binding]; other site 331678005376 [2Fe-2S] cluster binding site [ion binding]; other site 331678005377 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 331678005378 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 331678005379 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 331678005380 HIGH motif; other site 331678005381 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 331678005382 active site 331678005383 KMSKS motif; other site 331678005384 CagZ; Region: CagZ; pfam09053 331678005385 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 331678005386 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678005387 Walker A motif; other site 331678005388 ATP binding site [chemical binding]; other site 331678005389 Walker B motif; other site 331678005390 arginine finger; other site 331678005391 Peptidase family M41; Region: Peptidase_M41; pfam01434 331678005392 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 331678005393 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 331678005394 IHF dimer interface [polypeptide binding]; other site 331678005395 IHF - DNA interface [nucleotide binding]; other site 331678005396 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 331678005397 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 331678005398 transmembrane helices; other site 331678005399 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 331678005400 active site 331678005401 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 331678005402 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 331678005403 Intra-flagellar transport protein 57; Region: IFT57; pfam10498 331678005404 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 331678005405 GTPase Era; Reviewed; Region: era; PRK00089 331678005406 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 331678005407 G1 box; other site 331678005408 GTP/Mg2+ binding site [chemical binding]; other site 331678005409 Switch I region; other site 331678005410 G2 box; other site 331678005411 Switch II region; other site 331678005412 G3 box; other site 331678005413 G4 box; other site 331678005414 G5 box; other site 331678005415 KH domain; Region: KH_2; pfam07650 331678005416 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 331678005417 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 331678005418 RNA binding site [nucleotide binding]; other site 331678005419 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 331678005420 RNA binding site [nucleotide binding]; other site 331678005421 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 331678005422 RNA binding site [nucleotide binding]; other site 331678005423 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 331678005424 RNA binding site [nucleotide binding]; other site 331678005425 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 331678005426 RNA binding site [nucleotide binding]; other site 331678005427 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 331678005428 RNA binding site [nucleotide binding]; other site 331678005429 GTP-binding protein YchF; Reviewed; Region: PRK09601 331678005430 YchF GTPase; Region: YchF; cd01900 331678005431 G1 box; other site 331678005432 GTP/Mg2+ binding site [chemical binding]; other site 331678005433 Switch I region; other site 331678005434 G2 box; other site 331678005435 Switch II region; other site 331678005436 G3 box; other site 331678005437 G4 box; other site 331678005438 G5 box; other site 331678005439 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 331678005440 glutamate racemase; Provisional; Region: PRK00865 331678005441 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 331678005442 classical (c) SDRs; Region: SDR_c; cd05233 331678005443 NAD(P) binding site [chemical binding]; other site 331678005444 active site 331678005445 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 331678005446 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 331678005447 dimer interface [polypeptide binding]; other site 331678005448 catalytic residue [active] 331678005449 metal binding site [ion binding]; metal-binding site 331678005450 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 331678005451 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 331678005452 putative active site; other site 331678005453 catalytic residue [active] 331678005454 short chain dehydrogenase; Validated; Region: PRK08324 331678005455 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 331678005456 active site 331678005457 Zn2+ binding site [ion binding]; other site 331678005458 intersubunit interface [polypeptide binding]; other site 331678005459 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678005460 NAD(P) binding site [chemical binding]; other site 331678005461 active site 331678005462 recombination regulator RecX; Reviewed; Region: recX; PRK00117 331678005463 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 331678005464 putative nucleotide binding site [chemical binding]; other site 331678005465 uridine monophosphate binding site [chemical binding]; other site 331678005466 homohexameric interface [polypeptide binding]; other site 331678005467 elongation factor Ts; Provisional; Region: tsf; PRK09377 331678005468 UBA/TS-N domain; Region: UBA; pfam00627 331678005469 Elongation factor TS; Region: EF_TS; pfam00889 331678005470 Elongation factor TS; Region: EF_TS; pfam00889 331678005471 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 331678005472 rRNA interaction site [nucleotide binding]; other site 331678005473 S8 interaction site; other site 331678005474 putative laminin-1 binding site; other site 331678005475 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 331678005476 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 331678005477 23S rRNA interface [nucleotide binding]; other site 331678005478 L3 interface [polypeptide binding]; other site 331678005479 GTP-binding protein Der; Reviewed; Region: PRK00093 331678005480 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 331678005481 G1 box; other site 331678005482 GTP/Mg2+ binding site [chemical binding]; other site 331678005483 Switch I region; other site 331678005484 G2 box; other site 331678005485 Switch II region; other site 331678005486 G3 box; other site 331678005487 G4 box; other site 331678005488 G5 box; other site 331678005489 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 331678005490 G1 box; other site 331678005491 GTP/Mg2+ binding site [chemical binding]; other site 331678005492 Switch I region; other site 331678005493 G2 box; other site 331678005494 G3 box; other site 331678005495 Switch II region; other site 331678005496 G4 box; other site 331678005497 G5 box; other site 331678005498 antiporter inner membrane protein; Provisional; Region: PRK11670 331678005499 Domain of unknown function DUF59; Region: DUF59; pfam01883 331678005500 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 331678005501 Walker A motif; other site 331678005502 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 331678005503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 331678005504 Major Facilitator Superfamily; Region: MFS_1; pfam07690 331678005505 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 331678005506 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 331678005507 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 331678005508 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 331678005509 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 331678005510 TPR repeat; Region: TPR_11; pfam13414 331678005511 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678005512 TPR motif; other site 331678005513 binding surface 331678005514 TPR repeat; Region: TPR_11; pfam13414 331678005515 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 331678005516 Repair protein; Region: Repair_PSII; cl01535 331678005517 Repair protein; Region: Repair_PSII; pfam04536 331678005518 LemA family; Region: LemA; pfam04011 331678005519 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 331678005520 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 331678005521 Zn2+ binding site [ion binding]; other site 331678005522 Mg2+ binding site [ion binding]; other site 331678005523 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 331678005524 synthetase active site [active] 331678005525 NTP binding site [chemical binding]; other site 331678005526 metal binding site [ion binding]; metal-binding site 331678005527 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 331678005528 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 331678005529 excinuclease ABC subunit B; Provisional; Region: PRK05298 331678005530 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 331678005531 ATP binding site [chemical binding]; other site 331678005532 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 331678005533 nucleotide binding region [chemical binding]; other site 331678005534 ATP-binding site [chemical binding]; other site 331678005535 Ultra-violet resistance protein B; Region: UvrB; pfam12344 331678005536 UvrB/uvrC motif; Region: UVR; pfam02151 331678005537 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 331678005538 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 331678005539 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 331678005540 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 331678005541 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 331678005542 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 331678005543 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_1; cd03400 331678005544 Predicted permeases [General function prediction only]; Region: COG0795 331678005545 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 331678005546 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 331678005547 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 331678005548 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 331678005549 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 331678005550 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 331678005551 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 331678005552 DNA binding residues [nucleotide binding] 331678005553 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 331678005554 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 331678005555 active site 331678005556 HIGH motif; other site 331678005557 nucleotide binding site [chemical binding]; other site 331678005558 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 331678005559 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 331678005560 active site 331678005561 KMSKS motif; other site 331678005562 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 331678005563 tRNA binding surface [nucleotide binding]; other site 331678005564 anticodon binding site; other site 331678005565 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 331678005566 Clp protease; Region: CLP_protease; pfam00574 331678005567 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 331678005568 oligomer interface [polypeptide binding]; other site 331678005569 active site residues [active] 331678005570 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 331678005571 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 331678005572 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 331678005573 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 331678005574 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 331678005575 nucleophile elbow; other site 331678005576 Surface antigen; Region: Bac_surface_Ag; pfam01103 331678005577 stationary phase survival protein SurE; Provisional; Region: PRK13932 331678005578 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 331678005579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 331678005580 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 331678005581 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 331678005582 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 331678005583 DsbD alpha interface [polypeptide binding]; other site 331678005584 catalytic residues [active] 331678005585 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 331678005586 ResB-like family; Region: ResB; pfam05140 331678005587 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331678005588 sequence-specific DNA binding site [nucleotide binding]; other site 331678005589 salt bridge; other site 331678005590 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 331678005591 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 331678005592 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 331678005593 glutamine binding [chemical binding]; other site 331678005594 catalytic triad [active] 331678005595 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 331678005596 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 331678005597 Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635 331678005598 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 331678005599 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 331678005600 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 331678005601 Low molecular weight phosphatase family; Region: LMWPc; cd00115 331678005602 active site 331678005603 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 331678005604 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 331678005605 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 331678005606 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 331678005607 NAD(P) binding site [chemical binding]; other site 331678005608 catalytic residues [active] 331678005609 GTPase RsgA; Reviewed; Region: PRK00098 331678005610 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 331678005611 RNA binding site [nucleotide binding]; other site 331678005612 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 331678005613 GTPase/Zn-binding domain interface [polypeptide binding]; other site 331678005614 GTP/Mg2+ binding site [chemical binding]; other site 331678005615 G4 box; other site 331678005616 G5 box; other site 331678005617 G1 box; other site 331678005618 Switch I region; other site 331678005619 G2 box; other site 331678005620 G3 box; other site 331678005621 Switch II region; other site 331678005622 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 331678005623 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 331678005624 generic binding surface II; other site 331678005625 ssDNA binding site; other site 331678005626 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 331678005627 ATP binding site [chemical binding]; other site 331678005628 putative Mg++ binding site [ion binding]; other site 331678005629 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 331678005630 nucleotide binding region [chemical binding]; other site 331678005631 ATP-binding site [chemical binding]; other site 331678005632 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 331678005633 ribosome recycling factor; Reviewed; Region: frr; PRK00083 331678005634 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 331678005635 hinge region; other site 331678005636 Chlide_reductase_Y : Y subunit of chlorophyllide (chlide) reductase (BchY). Chlide reductase participates in photosynthetic pigment synthesis playing a role in the conversion of chlorophylls(Chl) into bacteriochlorophylls (BChl). Chlide reductase...; Region: Chlide_reductase_Y; cd01980 331678005637 chlorophyllide reductase subunit Y; Region: BchY; TIGR02015 331678005638 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 331678005639 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 331678005640 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 331678005641 generic binding surface II; other site 331678005642 generic binding surface I; other site 331678005643 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 331678005644 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 331678005645 Ligand binding site; other site 331678005646 oligomer interface; other site 331678005647 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 331678005648 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 331678005649 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 331678005650 Citrate synthase; Region: Citrate_synt; pfam00285 331678005651 oxalacetate binding site [chemical binding]; other site 331678005652 citrylCoA binding site [chemical binding]; other site 331678005653 coenzyme A binding site [chemical binding]; other site 331678005654 catalytic triad [active] 331678005655 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 331678005656 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 331678005657 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 331678005658 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 331678005659 ligand binding site [chemical binding]; other site 331678005660 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 331678005661 putative metal binding site [ion binding]; other site 331678005662 Uncharacterized conserved protein [Function unknown]; Region: COG1432 331678005663 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 331678005664 TPR repeat; Region: TPR_11; pfam13414 331678005665 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678005666 binding surface 331678005667 TPR motif; other site 331678005668 TPR repeat; Region: TPR_11; pfam13414 331678005669 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678005670 binding surface 331678005671 TPR motif; other site 331678005672 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 331678005673 chorismate binding enzyme; Region: Chorismate_bind; cl10555 331678005674 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 331678005675 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 331678005676 dimer interface [polypeptide binding]; other site 331678005677 tetramer interface [polypeptide binding]; other site 331678005678 PYR/PP interface [polypeptide binding]; other site 331678005679 TPP binding site [chemical binding]; other site 331678005680 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 331678005681 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 331678005682 TPP-binding site; other site 331678005683 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 331678005684 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 331678005685 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 331678005686 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 331678005687 substrate binding site [chemical binding]; other site 331678005688 oxyanion hole (OAH) forming residues; other site 331678005689 trimer interface [polypeptide binding]; other site 331678005690 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 331678005691 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 331678005692 active site 331678005693 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 331678005694 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 331678005695 acyl-activating enzyme (AAE) consensus motif; other site 331678005696 putative AMP binding site [chemical binding]; other site 331678005697 putative active site [active] 331678005698 putative CoA binding site [chemical binding]; other site 331678005699 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 331678005700 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331678005701 Coenzyme A binding pocket [chemical binding]; other site 331678005702 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 331678005703 cyanophycin synthetase; Provisional; Region: PRK14016 331678005704 ATP-grasp domain; Region: ATP-grasp_4; cl17255 331678005705 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 331678005706 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 331678005707 FMN binding site [chemical binding]; other site 331678005708 active site 331678005709 substrate binding site [chemical binding]; other site 331678005710 catalytic residue [active] 331678005711 dihydrodipicolinate reductase; Provisional; Region: PRK00048 331678005712 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 331678005713 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 331678005714 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 331678005715 ParB-like nuclease domain; Region: ParB; smart00470 331678005716 KorB domain; Region: KorB; pfam08535 331678005717 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 331678005718 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 331678005719 P-loop; other site 331678005720 Magnesium ion binding site [ion binding]; other site 331678005721 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 331678005722 Magnesium ion binding site [ion binding]; other site 331678005723 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 331678005724 active site 331678005725 DNA binding site [nucleotide binding] 331678005726 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 331678005727 MgtE intracellular N domain; Region: MgtE_N; pfam03448 331678005728 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 331678005729 Divalent cation transporter; Region: MgtE; pfam01769 331678005730 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 331678005731 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 331678005732 Ferredoxin [Energy production and conversion]; Region: COG1146 331678005733 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 331678005734 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 331678005735 Ligand Binding Site [chemical binding]; other site 331678005736 putative hydrolase; Provisional; Region: PRK11460 331678005737 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 331678005738 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 331678005739 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 331678005740 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 331678005741 substrate binding pocket [chemical binding]; other site 331678005742 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 331678005743 B12 binding site [chemical binding]; other site 331678005744 cobalt ligand [ion binding]; other site 331678005745 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 331678005746 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 331678005747 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 331678005748 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 331678005749 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 331678005750 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 331678005751 Uncharacterized protein family (UPF0259); Region: UPF0259; cl11642 331678005752 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 331678005753 active site residue [active] 331678005754 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 331678005755 Mechanosensitive ion channel; Region: MS_channel; pfam00924 331678005756 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 331678005757 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 331678005758 TPP-binding site [chemical binding]; other site 331678005759 dimer interface [polypeptide binding]; other site 331678005760 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 331678005761 PYR/PP interface [polypeptide binding]; other site 331678005762 dimer interface [polypeptide binding]; other site 331678005763 TPP binding site [chemical binding]; other site 331678005764 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 331678005765 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 331678005766 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 331678005767 putative active site [active] 331678005768 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 331678005769 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 331678005770 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 331678005771 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 331678005772 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 331678005773 PAS domain S-box; Region: sensory_box; TIGR00229 331678005774 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 331678005775 dimer interface [polypeptide binding]; other site 331678005776 phosphorylation site [posttranslational modification] 331678005777 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 331678005778 ATP binding site [chemical binding]; other site 331678005779 Mg2+ binding site [ion binding]; other site 331678005780 G-X-G motif; other site 331678005781 Response regulator receiver domain; Region: Response_reg; pfam00072 331678005782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 331678005783 active site 331678005784 phosphorylation site [posttranslational modification] 331678005785 intermolecular recognition site; other site 331678005786 dimerization interface [polypeptide binding]; other site 331678005787 Hpt domain; Region: Hpt; pfam01627 331678005788 putative binding surface; other site 331678005789 active site 331678005790 FIST N domain; Region: FIST; pfam08495 331678005791 FIST C domain; Region: FIST_C; pfam10442 331678005792 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 331678005793 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331678005794 substrate binding pocket [chemical binding]; other site 331678005795 Ion channel; Region: Ion_trans_2; pfam07885 331678005796 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 331678005797 membrane-bound complex binding site; other site 331678005798 hinge residues; other site 331678005799 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 331678005800 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678005801 enoyl-CoA hydratase; Validated; Region: PRK08139 331678005802 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 331678005803 substrate binding site [chemical binding]; other site 331678005804 oxyanion hole (OAH) forming residues; other site 331678005805 trimer interface [polypeptide binding]; other site 331678005806 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 331678005807 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_6; cd06256 331678005808 putative active site [active] 331678005809 Zn binding site [ion binding]; other site 331678005810 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 331678005811 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 331678005812 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 331678005813 putative deacylase active site [active] 331678005814 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 331678005815 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 331678005816 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 331678005817 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 331678005818 nucleophile elbow; other site 331678005819 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 331678005820 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 331678005821 NAD(P) binding site [chemical binding]; other site 331678005822 catalytic residues [active] 331678005823 AAA domain; Region: AAA_32; pfam13654 331678005824 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 331678005825 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 331678005826 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 331678005827 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 331678005828 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 331678005829 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 331678005830 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 331678005831 Peptidase family U32; Region: Peptidase_U32; pfam01136 331678005832 sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910 331678005833 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 331678005834 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 331678005835 FAD binding pocket [chemical binding]; other site 331678005836 FAD binding motif [chemical binding]; other site 331678005837 phosphate binding motif [ion binding]; other site 331678005838 beta-alpha-beta structure motif; other site 331678005839 NAD binding pocket [chemical binding]; other site 331678005840 Iron coordination center [ion binding]; other site 331678005841 Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941 331678005842 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 331678005843 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 331678005844 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 331678005845 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 331678005846 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 331678005847 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 331678005848 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 331678005849 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 331678005850 Mechanosensitive ion channel; Region: MS_channel; pfam00924 331678005851 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 331678005852 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 331678005853 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 331678005854 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 331678005855 trimer interface [polypeptide binding]; other site 331678005856 putative metal binding site [ion binding]; other site 331678005857 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 331678005858 Putative addiction module component; Region: Unstab_antitox; pfam09720 331678005859 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678005860 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678005861 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 331678005862 UDP-glucose 4-epimerase (G4E), subgroup 5, extended (e) SDRs; Region: UDP_G4E_5_SDR_e; cd05264 331678005863 putative NAD(P) binding site [chemical binding]; other site 331678005864 active site 331678005865 putative substrate binding site [chemical binding]; other site 331678005866 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 331678005867 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 331678005868 active site 331678005869 Transposase; Region: HTH_Tnp_1; cl17663 331678005870 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678005871 Predicted transcriptional regulator [Transcription]; Region: COG2378 331678005872 HTH domain; Region: HTH_11; cl17392 331678005873 WYL domain; Region: WYL; pfam13280 331678005874 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 331678005875 active site 331678005876 catalytic site [active] 331678005877 substrate binding site [chemical binding]; other site 331678005878 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 331678005879 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678005880 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 331678005881 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 331678005882 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 331678005883 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 331678005884 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 331678005885 CT1975-like protein; Region: Cas_CT1975; pfam09344 331678005886 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 331678005887 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 331678005888 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 331678005889 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 331678005890 HipA-like N-terminal domain; Region: HipA_N; pfam07805 331678005891 HipA-like C-terminal domain; Region: HipA_C; pfam07804 331678005892 HipA N-terminal domain; Region: Couple_hipA; pfam13657 331678005893 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331678005894 non-specific DNA binding site [nucleotide binding]; other site 331678005895 salt bridge; other site 331678005896 sequence-specific DNA binding site [nucleotide binding]; other site 331678005897 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 331678005898 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 331678005899 Walker A/P-loop; other site 331678005900 ATP binding site [chemical binding]; other site 331678005901 Q-loop/lid; other site 331678005902 ABC transporter signature motif; other site 331678005903 Walker B; other site 331678005904 D-loop; other site 331678005905 H-loop/switch region; other site 331678005906 B12 binding domain; Region: B12-binding; pfam02310 331678005907 B12 binding site [chemical binding]; other site 331678005908 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 331678005909 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678005910 FeS/SAM binding site; other site 331678005911 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 331678005912 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 331678005913 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 331678005914 Zn2+ binding site [ion binding]; other site 331678005915 Mg2+ binding site [ion binding]; other site 331678005916 YtxH-like protein; Region: YtxH; pfam12732 331678005917 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 331678005918 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 331678005919 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 331678005920 hinge; other site 331678005921 active site 331678005922 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 331678005923 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 331678005924 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 331678005925 dimer interface [polypeptide binding]; other site 331678005926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678005927 catalytic residue [active] 331678005928 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 331678005929 alanine racemase; Reviewed; Region: alr; PRK00053 331678005930 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 331678005931 active site 331678005932 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 331678005933 dimer interface [polypeptide binding]; other site 331678005934 substrate binding site [chemical binding]; other site 331678005935 catalytic residues [active] 331678005936 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 331678005937 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 331678005938 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 331678005939 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 331678005940 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 331678005941 FMN binding site [chemical binding]; other site 331678005942 active site 331678005943 catalytic residues [active] 331678005944 substrate binding site [chemical binding]; other site 331678005945 recombinase A; Provisional; Region: recA; PRK09354 331678005946 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 331678005947 hexamer interface [polypeptide binding]; other site 331678005948 Walker A motif; other site 331678005949 ATP binding site [chemical binding]; other site 331678005950 Walker B motif; other site 331678005951 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 331678005952 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 331678005953 putative NADP binding site [chemical binding]; other site 331678005954 putative substrate binding site [chemical binding]; other site 331678005955 active site 331678005956 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678005957 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 331678005958 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 331678005959 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 331678005960 trigger factor; Region: tig; TIGR00115 331678005961 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 331678005962 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 331678005963 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 331678005964 dimerization interface [polypeptide binding]; other site 331678005965 active site 331678005966 Dihydroneopterin aldolase; Region: FolB; smart00905 331678005967 active site 331678005968 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 331678005969 catalytic center binding site [active] 331678005970 ATP binding site [chemical binding]; other site 331678005971 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 331678005972 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 331678005973 P loop; other site 331678005974 Nucleotide binding site [chemical binding]; other site 331678005975 DTAP/Switch II; other site 331678005976 Switch I; other site 331678005977 Bacteriochlorophyll C binding protein; Region: Bac_chlorC; pfam02043 331678005978 Chlorosome envelope protein C; Region: Chlorosome_CsmC; pfam11098 331678005979 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 331678005980 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 331678005981 P loop; other site 331678005982 Nucleotide binding site [chemical binding]; other site 331678005983 DTAP/Switch II; other site 331678005984 Switch I; other site 331678005985 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 331678005986 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 331678005987 FAD binding pocket [chemical binding]; other site 331678005988 FAD binding motif [chemical binding]; other site 331678005989 phosphate binding motif [ion binding]; other site 331678005990 beta-alpha-beta structure motif; other site 331678005991 NAD binding pocket [chemical binding]; other site 331678005992 Iron coordination center [ion binding]; other site 331678005993 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 331678005994 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 331678005995 dimer interface [polypeptide binding]; other site 331678005996 ssDNA binding site [nucleotide binding]; other site 331678005997 tetramer (dimer of dimers) interface [polypeptide binding]; other site 331678005998 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 331678005999 DNA polymerase III, delta subunit; Region: holA; TIGR01128 331678006000 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 331678006001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678006002 NAD(P) binding site [chemical binding]; other site 331678006003 active site 331678006004 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 331678006005 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 331678006006 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 331678006007 catalytic residue [active] 331678006008 Cna protein B-type domain; Region: Cna_B_2; pfam13715 331678006009 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 331678006010 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 331678006011 N-terminal plug; other site 331678006012 ligand-binding site [chemical binding]; other site 331678006013 magnesium chelatase, H subunit; Region: BchH; TIGR02025 331678006014 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 331678006015 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 331678006016 magnesium chelatase subunit H; Provisional; Region: PRK12493 331678006017 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 331678006018 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 331678006019 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 331678006020 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678006021 S-adenosylmethionine binding site [chemical binding]; other site 331678006022 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 331678006023 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 331678006024 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 331678006025 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678006026 FeS/SAM binding site; other site 331678006027 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 331678006028 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 331678006029 putative dimer interface [polypeptide binding]; other site 331678006030 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 331678006031 activation loop (A-loop); other site 331678006032 Predicted membrane protein [Function unknown]; Region: COG3174 331678006033 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 331678006034 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 331678006035 Peptidase family M23; Region: Peptidase_M23; pfam01551 331678006036 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 331678006037 hypothetical protein; Provisional; Region: PRK09256 331678006038 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 331678006039 FOG: WD40 repeat [General function prediction only]; Region: COG2319 331678006040 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 331678006041 structural tetrad; other site 331678006042 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 331678006043 putative active site [active] 331678006044 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 331678006045 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 331678006046 DXD motif; other site 331678006047 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 331678006048 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 331678006049 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 331678006050 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 331678006051 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 331678006052 putative active site [active] 331678006053 putative metal binding site [ion binding]; other site 331678006054 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 331678006055 bacteriochlorophyll c synthase; Provisional; Region: PRK12392 331678006056 UbiA prenyltransferase family; Region: UbiA; pfam01040 331678006057 bacteriochlorophyll c synthase; Provisional; Region: PRK12392 331678006058 UbiA prenyltransferase family; Region: UbiA; pfam01040 331678006059 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14340 331678006060 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 331678006061 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678006062 FeS/SAM binding site; other site 331678006063 TRAM domain; Region: TRAM; cl01282 331678006064 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 331678006065 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 331678006066 trimerization site [polypeptide binding]; other site 331678006067 active site 331678006068 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 331678006069 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 331678006070 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 331678006071 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 331678006072 catalytic residue [active] 331678006073 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 331678006074 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 331678006075 dimer interface [polypeptide binding]; other site 331678006076 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678006077 catalytic residue [active] 331678006078 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331678006079 non-specific DNA binding site [nucleotide binding]; other site 331678006080 salt bridge; other site 331678006081 sequence-specific DNA binding site [nucleotide binding]; other site 331678006082 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 331678006083 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 331678006084 Domain of unknown function DUF21; Region: DUF21; pfam01595 331678006085 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 331678006086 Transporter associated domain; Region: CorC_HlyC; smart01091 331678006087 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 331678006088 active site 331678006089 multimer interface [polypeptide binding]; other site 331678006090 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 331678006091 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 331678006092 Domain of unknown function DUF20; Region: UPF0118; pfam01594 331678006093 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 331678006094 RNA methyltransferase, RsmE family; Region: TIGR00046 331678006095 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 331678006096 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 331678006097 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 331678006098 active site 331678006099 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 331678006100 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 331678006101 nucleotide binding site [chemical binding]; other site 331678006102 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 331678006103 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 331678006104 active site 331678006105 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 331678006106 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 331678006107 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678006108 FeS/SAM binding site; other site 331678006109 HemN C-terminal domain; Region: HemN_C; pfam06969 331678006110 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 331678006111 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331678006112 active site 331678006113 motif I; other site 331678006114 motif II; other site 331678006115 glycogen synthase; Provisional; Region: PRK14098 331678006116 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 331678006117 ADP-binding pocket [chemical binding]; other site 331678006118 homodimer interface [polypeptide binding]; other site 331678006119 Bacterial Ig-like domain; Region: Big_5; pfam13205 331678006120 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 331678006121 V4R domain; Region: V4R; cl15268 331678006122 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 331678006123 Fic family protein [Function unknown]; Region: COG3177 331678006124 Fic/DOC family; Region: Fic; pfam02661 331678006125 TfoX C-terminal domain; Region: TfoX_C; pfam04994 331678006126 Pathogenicity locus; Region: Cdd1; pfam11731 331678006127 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 331678006128 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 331678006129 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331678006130 motif II; other site 331678006131 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 331678006132 Putative addiction module component; Region: Unstab_antitox; pfam09720 331678006133 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 331678006134 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 331678006135 P-loop; other site 331678006136 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 331678006137 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 331678006138 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 331678006139 light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842 331678006140 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 331678006141 Domain of unknown function DUF77; Region: DUF77; pfam01910 331678006142 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 331678006143 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 331678006144 GDP-binding site [chemical binding]; other site 331678006145 ACT binding site; other site 331678006146 IMP binding site; other site 331678006147 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 331678006148 G1 box; other site 331678006149 GTP/Mg2+ binding site [chemical binding]; other site 331678006150 Switch I region; other site 331678006151 G2 box; other site 331678006152 G3 box; other site 331678006153 Switch II region; other site 331678006154 G4 box; other site 331678006155 G5 box; other site 331678006156 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 331678006157 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 331678006158 active site 331678006159 HIGH motif; other site 331678006160 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 331678006161 KMSKS motif; other site 331678006162 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 331678006163 tRNA binding surface [nucleotide binding]; other site 331678006164 anticodon binding site; other site 331678006165 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 331678006166 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 331678006167 Substrate binding site; other site 331678006168 Cupin domain; Region: Cupin_2; cl17218 331678006169 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 331678006170 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 331678006171 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 331678006172 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 331678006173 alphaNTD homodimer interface [polypeptide binding]; other site 331678006174 alphaNTD - beta interaction site [polypeptide binding]; other site 331678006175 alphaNTD - beta' interaction site [polypeptide binding]; other site 331678006176 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 331678006177 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 331678006178 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 331678006179 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 331678006180 RNA binding surface [nucleotide binding]; other site 331678006181 30S ribosomal protein S11; Validated; Region: PRK05309 331678006182 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 331678006183 30S ribosomal protein S13; Region: bact_S13; TIGR03631 331678006184 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 331678006185 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 331678006186 rRNA binding site [nucleotide binding]; other site 331678006187 predicted 30S ribosome binding site; other site 331678006188 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 331678006189 active site 331678006190 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 331678006191 SecY translocase; Region: SecY; pfam00344 331678006192 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 331678006193 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 331678006194 23S rRNA binding site [nucleotide binding]; other site 331678006195 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 331678006196 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 331678006197 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 331678006198 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 331678006199 5S rRNA interface [nucleotide binding]; other site 331678006200 L27 interface [polypeptide binding]; other site 331678006201 23S rRNA interface [nucleotide binding]; other site 331678006202 L5 interface [polypeptide binding]; other site 331678006203 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 331678006204 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 331678006205 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 331678006206 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 331678006207 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 331678006208 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 331678006209 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 331678006210 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 331678006211 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 331678006212 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 331678006213 RNA binding site [nucleotide binding]; other site 331678006214 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 331678006215 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 331678006216 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 331678006217 putative translocon interaction site; other site 331678006218 23S rRNA interface [nucleotide binding]; other site 331678006219 signal recognition particle (SRP54) interaction site; other site 331678006220 L23 interface [polypeptide binding]; other site 331678006221 trigger factor interaction site; other site 331678006222 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 331678006223 23S rRNA interface [nucleotide binding]; other site 331678006224 5S rRNA interface [nucleotide binding]; other site 331678006225 putative antibiotic binding site [chemical binding]; other site 331678006226 L25 interface [polypeptide binding]; other site 331678006227 L27 interface [polypeptide binding]; other site 331678006228 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 331678006229 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 331678006230 G-X-X-G motif; other site 331678006231 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 331678006232 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 331678006233 putative translocon binding site; other site 331678006234 protein-rRNA interface [nucleotide binding]; other site 331678006235 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 331678006236 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 331678006237 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 331678006238 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 331678006239 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 331678006240 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 331678006241 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 331678006242 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 331678006243 elongation factor Tu; Reviewed; Region: PRK00049 331678006244 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 331678006245 G1 box; other site 331678006246 GEF interaction site [polypeptide binding]; other site 331678006247 GTP/Mg2+ binding site [chemical binding]; other site 331678006248 Switch I region; other site 331678006249 G2 box; other site 331678006250 G3 box; other site 331678006251 Switch II region; other site 331678006252 G4 box; other site 331678006253 G5 box; other site 331678006254 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 331678006255 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 331678006256 Antibiotic Binding Site [chemical binding]; other site 331678006257 elongation factor G; Reviewed; Region: PRK00007 331678006258 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 331678006259 G1 box; other site 331678006260 putative GEF interaction site [polypeptide binding]; other site 331678006261 GTP/Mg2+ binding site [chemical binding]; other site 331678006262 Switch I region; other site 331678006263 G2 box; other site 331678006264 G3 box; other site 331678006265 Switch II region; other site 331678006266 G4 box; other site 331678006267 G5 box; other site 331678006268 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 331678006269 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 331678006270 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 331678006271 30S ribosomal protein S7; Validated; Region: PRK05302 331678006272 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 331678006273 S17 interaction site [polypeptide binding]; other site 331678006274 S8 interaction site; other site 331678006275 16S rRNA interaction site [nucleotide binding]; other site 331678006276 streptomycin interaction site [chemical binding]; other site 331678006277 23S rRNA interaction site [nucleotide binding]; other site 331678006278 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 331678006279 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 331678006280 Predicted membrane protein [Function unknown]; Region: COG4485 331678006281 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 331678006282 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 331678006283 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 331678006284 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 331678006285 Probable Catalytic site; other site 331678006286 metal-binding site 331678006287 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 331678006288 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 331678006289 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 331678006290 dimerization domain swap beta strand [polypeptide binding]; other site 331678006291 regulatory protein interface [polypeptide binding]; other site 331678006292 active site 331678006293 regulatory phosphorylation site [posttranslational modification]; other site 331678006294 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 331678006295 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331678006296 Coenzyme A binding pocket [chemical binding]; other site 331678006297 GTPase CgtA; Reviewed; Region: obgE; PRK12299 331678006298 GTP1/OBG; Region: GTP1_OBG; pfam01018 331678006299 Obg GTPase; Region: Obg; cd01898 331678006300 G1 box; other site 331678006301 GTP/Mg2+ binding site [chemical binding]; other site 331678006302 Switch I region; other site 331678006303 G2 box; other site 331678006304 G3 box; other site 331678006305 Switch II region; other site 331678006306 G4 box; other site 331678006307 G5 box; other site 331678006308 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 331678006309 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 331678006310 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 331678006311 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 331678006312 GatB domain; Region: GatB_Yqey; smart00845 331678006313 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 331678006314 putative amphipathic alpha helix; other site 331678006315 Clp amino terminal domain; Region: Clp_N; pfam02861 331678006316 Clp amino terminal domain; Region: Clp_N; pfam02861 331678006317 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678006318 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 331678006319 Walker A motif; other site 331678006320 ATP binding site [chemical binding]; other site 331678006321 Walker B motif; other site 331678006322 arginine finger; other site 331678006323 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 331678006324 iron-sulfur cluster [ion binding]; other site 331678006325 [2Fe-2S] cluster binding site [ion binding]; other site 331678006326 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 331678006327 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 331678006328 active site 331678006329 FMN binding site [chemical binding]; other site 331678006330 substrate binding site [chemical binding]; other site 331678006331 3Fe-4S cluster binding site [ion binding]; other site 331678006332 von Willebrand factor type A domain; Region: VWA_2; pfam13519 331678006333 metal ion-dependent adhesion site (MIDAS); other site 331678006334 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 331678006335 metal ion-dependent adhesion site (MIDAS); other site 331678006336 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 331678006337 Transposase domain (DUF772); Region: DUF772; pfam05598 331678006338 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 331678006339 DDE superfamily endonuclease; Region: DDE_4; cl17710 331678006340 nif11-like leader peptide domain; Region: ocin_TIGR03798 331678006341 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 331678006342 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 331678006343 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331678006344 Walker A/P-loop; other site 331678006345 ATP binding site [chemical binding]; other site 331678006346 Q-loop/lid; other site 331678006347 ABC transporter signature motif; other site 331678006348 Walker B; other site 331678006349 D-loop; other site 331678006350 H-loop/switch region; other site 331678006351 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 331678006352 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 331678006353 putative active site [active] 331678006354 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 331678006355 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331678006356 Walker A/P-loop; other site 331678006357 ATP binding site [chemical binding]; other site 331678006358 Q-loop/lid; other site 331678006359 ABC transporter signature motif; other site 331678006360 Walker B; other site 331678006361 D-loop; other site 331678006362 H-loop/switch region; other site 331678006363 Outer membrane efflux protein; Region: OEP; pfam02321 331678006364 Transposase IS200 like; Region: Y1_Tnp; cl00848 331678006365 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 331678006366 CRISPR/Cas system-associated protein Csx15; Region: Csx15_I-U; cd09766 331678006367 Transposase IS200 like; Region: Y1_Tnp; cl00848 331678006368 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 331678006369 DNA binding residues [nucleotide binding] 331678006370 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 331678006371 oligomeric interface; other site 331678006372 putative active site [active] 331678006373 homodimer interface [polypeptide binding]; other site 331678006374 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 331678006375 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 331678006376 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 331678006377 Protein of unknown function DUF58; Region: DUF58; pfam01882 331678006378 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 331678006379 metal ion-dependent adhesion site (MIDAS); other site 331678006380 MoxR-like ATPases [General function prediction only]; Region: COG0714 331678006381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678006382 Walker A motif; other site 331678006383 ATP binding site [chemical binding]; other site 331678006384 Walker B motif; other site 331678006385 arginine finger; other site 331678006386 UGMP family protein; Validated; Region: PRK09604 331678006387 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 331678006388 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 331678006389 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 331678006390 active site 331678006391 Preprotein translocase subunit; Region: YajC; pfam02699 331678006392 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 331678006393 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 331678006394 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 331678006395 catalytic site [active] 331678006396 subunit interface [polypeptide binding]; other site 331678006397 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 331678006398 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 331678006399 B12 binding site [chemical binding]; other site 331678006400 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 331678006401 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678006402 FeS/SAM binding site; other site 331678006403 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 331678006404 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 331678006405 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 331678006406 Sodium Bile acid symporter family; Region: SBF; pfam01758 331678006407 Uncharacterized protein domain similar to Clostridium thermocellum 2751; Region: Cthe_2751_like; cd11743 331678006408 Uncharacterized conserved protein [Function unknown]; Region: COG4095 331678006409 pyrroline-5-carboxylate reductase; Region: PLN02688 331678006410 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 331678006411 Oxygen tolerance; Region: BatD; pfam13584 331678006412 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 331678006413 MoaE homodimer interface [polypeptide binding]; other site 331678006414 MoaD interaction [polypeptide binding]; other site 331678006415 active site residues [active] 331678006416 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 331678006417 MoaE interaction surface [polypeptide binding]; other site 331678006418 MoeB interaction surface [polypeptide binding]; other site 331678006419 thiocarboxylated glycine; other site 331678006420 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 331678006421 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 331678006422 dimer interface [polypeptide binding]; other site 331678006423 putative functional site; other site 331678006424 putative MPT binding site; other site 331678006425 bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604 331678006426 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 331678006427 trimer interface [polypeptide binding]; other site 331678006428 dimer interface [polypeptide binding]; other site 331678006429 putative active site [active] 331678006430 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 331678006431 MPT binding site; other site 331678006432 trimer interface [polypeptide binding]; other site 331678006433 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 331678006434 Small subunit of Arsenite oxidase (ArOX) family, Rieske domain; ArOX is a molybdenum/iron protein involved in the detoxification of arsenic, oxidizing it to arsenate. It consists of two subunits, a large subunit similar to members of the DMSO reductase...; Region: Rieske_ArOX_small; cd03476 331678006435 [2Fe-2S] cluster binding site [ion binding]; other site 331678006436 subunit interaction site [polypeptide binding]; other site 331678006437 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 331678006438 arsenite oxidase, large subunit; Region: arsenite_ox_L; TIGR02693 331678006439 molybdopterin cofactor binding site; other site 331678006440 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 331678006441 molybdopterin cofactor binding site; other site 331678006442 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 331678006443 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678006444 FeS/SAM binding site; other site 331678006445 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 331678006446 MOSC domain; Region: MOSC; pfam03473 331678006447 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 331678006448 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 331678006449 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 331678006450 Transposase [DNA replication, recombination, and repair]; Region: COG5421 331678006451 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 331678006452 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 331678006453 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 331678006454 active site 331678006455 catalytic site [active] 331678006456 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 331678006457 Histidine kinase N terminal; Region: HisK_N; pfam09385 331678006458 Proteolipid membrane potential modulator; Region: Pmp3; cl00431 331678006459 putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MobA; Provisional; Region: PRK14490 331678006460 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 331678006461 Walker A motif; other site 331678006462 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 331678006463 GTP binding site; other site 331678006464 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 331678006465 Ligand Binding Site [chemical binding]; other site 331678006466 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 331678006467 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 331678006468 catalytic loop [active] 331678006469 iron binding site [ion binding]; other site 331678006470 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 331678006471 FAD binding pocket [chemical binding]; other site 331678006472 FAD binding motif [chemical binding]; other site 331678006473 phosphate binding motif [ion binding]; other site 331678006474 beta-alpha-beta structure motif; other site 331678006475 NAD binding pocket [chemical binding]; other site 331678006476 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 331678006477 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 331678006478 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 331678006479 FMN-binding domain; Region: FMN_bind; cl01081 331678006480 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 331678006481 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 331678006482 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 331678006483 thiosulfate reductase PhsA; Provisional; Region: PRK15488 331678006484 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 331678006485 putative [Fe4-S4] binding site [ion binding]; other site 331678006486 putative molybdopterin cofactor binding site [chemical binding]; other site 331678006487 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 331678006488 molybdopterin cofactor binding site; other site 331678006489 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 331678006490 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 331678006491 SOUL heme-binding protein; Region: SOUL; pfam04832 331678006492 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 331678006493 Domain of unknown function (DUF202); Region: DUF202; pfam02656 331678006494 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 331678006495 dimer interface [polypeptide binding]; other site 331678006496 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 331678006497 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 331678006498 active site 331678006499 Na/Ca binding site [ion binding]; other site 331678006500 catalytic site [active] 331678006501 heat shock protein HtpX; Provisional; Region: PRK05457 331678006502 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 331678006503 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 331678006504 Coenzyme A binding pocket [chemical binding]; other site 331678006505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678006506 S-adenosylmethionine binding site [chemical binding]; other site 331678006507 Cupin domain; Region: Cupin_2; pfam07883 331678006508 SEC-C motif; Region: SEC-C; pfam02810 331678006509 Transposase [DNA replication, recombination, and repair]; Region: COG5421 331678006510 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 331678006511 putative transposase OrfB; Reviewed; Region: PHA02517 331678006512 HTH-like domain; Region: HTH_21; pfam13276 331678006513 Integrase core domain; Region: rve; pfam00665 331678006514 Integrase core domain; Region: rve_3; pfam13683 331678006515 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 331678006516 Transposase; Region: HTH_Tnp_1; pfam01527 331678006517 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678006518 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331678006519 non-specific DNA binding site [nucleotide binding]; other site 331678006520 salt bridge; other site 331678006521 sequence-specific DNA binding site [nucleotide binding]; other site 331678006522 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 331678006523 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 331678006524 FAD binding domain; Region: FAD_binding_4; pfam01565 331678006525 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 331678006526 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; pfam09603 331678006527 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 331678006528 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 331678006529 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 331678006530 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 331678006531 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 331678006532 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 331678006533 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 331678006534 active site 331678006535 prephenate dehydrogenase; Validated; Region: PRK08507 331678006536 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 331678006537 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 331678006538 ATP-NAD kinase; Region: NAD_kinase; pfam01513 331678006539 Transposase domain (DUF772); Region: DUF772; pfam05598 331678006540 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 331678006541 TPR repeat; Region: TPR_11; pfam13414 331678006542 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 331678006543 binding surface 331678006544 TPR motif; other site 331678006545 TPR repeat; Region: TPR_11; pfam13414 331678006546 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 331678006547 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678006548 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 331678006549 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 331678006550 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 331678006551 Walker A motif; other site 331678006552 ATP binding site [chemical binding]; other site 331678006553 Walker B motif; other site 331678006554 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 331678006555 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 331678006556 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 331678006557 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 331678006558 catalytic core [active] 331678006559 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 331678006560 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 331678006561 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 331678006562 membrane protein; Provisional; Region: PRK14410 331678006563 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 331678006564 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 331678006565 dimerization interface [polypeptide binding]; other site 331678006566 putative ATP binding site [chemical binding]; other site 331678006567 aspartate kinase III; Validated; Region: PRK09084 331678006568 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 331678006569 nucleotide binding site [chemical binding]; other site 331678006570 substrate binding site [chemical binding]; other site 331678006571 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 331678006572 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 331678006573 NlpC/P60 family; Region: NLPC_P60; pfam00877 331678006574 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 331678006575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678006576 S-adenosylmethionine binding site [chemical binding]; other site 331678006577 exopolyphosphatase; Region: exo_poly_only; TIGR03706 331678006578 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 331678006579 Transposase domain (DUF772); Region: DUF772; pfam05598 331678006580 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 331678006581 DDE superfamily endonuclease; Region: DDE_4; cl17710 331678006582 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821 331678006583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678006584 S-adenosylmethionine binding site [chemical binding]; other site 331678006585 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 331678006586 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 331678006587 inhibitor-cofactor binding pocket; inhibition site 331678006588 pyridoxal 5'-phosphate binding site [chemical binding]; other site 331678006589 catalytic residue [active] 331678006590 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 331678006591 AAA domain; Region: AAA_26; pfam13500 331678006592 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 331678006593 ADP binding site [chemical binding]; other site 331678006594 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 331678006595 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678006596 S-adenosylmethionine binding site [chemical binding]; other site 331678006597 Protein of unknown function (DUF452); Region: DUF452; cl01062 331678006598 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 331678006599 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 331678006600 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 331678006601 catalytic residue [active] 331678006602 biotin synthase; Region: bioB; TIGR00433 331678006603 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 331678006604 FeS/SAM binding site; other site 331678006605 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 331678006606 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 331678006607 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 331678006608 putative Zn2+ binding site [ion binding]; other site 331678006609 putative DNA binding site [nucleotide binding]; other site 331678006610 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 331678006611 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 331678006612 Rubrerythrin [Energy production and conversion]; Region: COG1592 331678006613 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 331678006614 binuclear metal center [ion binding]; other site 331678006615 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 331678006616 iron binding site [ion binding]; other site 331678006617 Rubredoxin [Energy production and conversion]; Region: COG1773 331678006618 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 331678006619 iron binding site [ion binding]; other site 331678006620 Rubredoxin [Energy production and conversion]; Region: COG1773 331678006621 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 331678006622 iron binding site [ion binding]; other site 331678006623 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 331678006624 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 331678006625 active site 331678006626 FMN binding site [chemical binding]; other site 331678006627 substrate binding site [chemical binding]; other site 331678006628 3Fe-4S cluster binding site [ion binding]; other site 331678006629 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 331678006630 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 331678006631 active site 331678006632 metal binding site [ion binding]; metal-binding site 331678006633 DNA topoisomerase I; Validated; Region: PRK06599 331678006634 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 331678006635 active site 331678006636 interdomain interaction site; other site 331678006637 putative metal-binding site [ion binding]; other site 331678006638 nucleotide binding site [chemical binding]; other site 331678006639 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 331678006640 domain I; other site 331678006641 DNA binding groove [nucleotide binding] 331678006642 phosphate binding site [ion binding]; other site 331678006643 domain II; other site 331678006644 domain III; other site 331678006645 nucleotide binding site [chemical binding]; other site 331678006646 catalytic site [active] 331678006647 domain IV; other site 331678006648 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 331678006649 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 331678006650 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 331678006651 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 331678006652 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 331678006653 G1 box; other site 331678006654 GTP/Mg2+ binding site [chemical binding]; other site 331678006655 Switch I region; other site 331678006656 G2 box; other site 331678006657 G3 box; other site 331678006658 Switch II region; other site 331678006659 G4 box; other site 331678006660 G5 box; other site 331678006661 Nucleoside recognition; Region: Gate; pfam07670 331678006662 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 331678006663 Nucleoside recognition; Region: Gate; pfam07670 331678006664 FeoA domain; Region: FeoA; pfam04023 331678006665 aconitate hydratase; Validated; Region: PRK09277 331678006666 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 331678006667 substrate binding site [chemical binding]; other site 331678006668 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 331678006669 ligand binding site [chemical binding]; other site 331678006670 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 331678006671 substrate binding site [chemical binding]; other site 331678006672 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 331678006673 nucleotide binding site/active site [active] 331678006674 HIT family signature motif; other site 331678006675 catalytic residue [active] 331678006676 SprT homologues; Region: SprT; cl01182 331678006677 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 331678006678 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 331678006679 phosphate binding site [ion binding]; other site 331678006680 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 331678006681 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 331678006682 dimer interface [polypeptide binding]; other site 331678006683 active site 331678006684 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 331678006685 Esterase/lipase [General function prediction only]; Region: COG1647 331678006686 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 331678006687 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 331678006688 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 331678006689 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 331678006690 DNA binding site [nucleotide binding] 331678006691 active site 331678006692 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 331678006693 active site 331678006694 intersubunit interactions; other site 331678006695 catalytic residue [active] 331678006696 Domain of unknown function (DUF4071); Region: DUF4071; pfam13281 331678006697 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 331678006698 TIR domain; Region: TIR_2; pfam13676 331678006699 Uncharacterized conserved protein [Function unknown]; Region: COG1262 331678006700 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 331678006701 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 331678006702 Domain of unknown function (DUF955); Region: DUF955; cl01076 331678006703 deoxyhypusine synthase-like protein; Provisional; Region: PRK02492 331678006704 deoxyhypusine synthase; Region: dhys; TIGR00321 331678006705 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 331678006706 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 331678006707 active site 331678006708 HIGH motif; other site 331678006709 dimer interface [polypeptide binding]; other site 331678006710 KMSKS motif; other site 331678006711 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 331678006712 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331678006713 motif II; other site 331678006714 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 331678006715 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 331678006716 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 331678006717 active site 331678006718 HIGH motif; other site 331678006719 KMSK motif region; other site 331678006720 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 331678006721 tRNA binding surface [nucleotide binding]; other site 331678006722 anticodon binding site; other site 331678006723 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 331678006724 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 331678006725 active site 331678006726 (T/H)XGH motif; other site 331678006727 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 331678006728 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 331678006729 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 331678006730 non-specific DNA binding site [nucleotide binding]; other site 331678006731 salt bridge; other site 331678006732 sequence-specific DNA binding site [nucleotide binding]; other site 331678006733 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 331678006734 Domain of unknown function (DUF955); Region: DUF955; pfam06114 331678006735 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 331678006736 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 331678006737 Protein of unknown function (DUF499); Region: DUF499; pfam04465 331678006738 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 331678006739 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 331678006740 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 331678006741 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 331678006742 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 331678006743 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 331678006744 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 331678006745 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 331678006746 nucleotide binding region [chemical binding]; other site 331678006747 ATP-binding site [chemical binding]; other site 331678006748 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 331678006749 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 331678006750 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 331678006751 F0F1 ATP synthase subunit B; Provisional; Region: PRK14472 331678006752 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 331678006753 ATP synthase subunit C; Region: ATP-synt_C; cl00466 331678006754 F0F1 ATP synthase subunit A; Provisional; Region: PRK13419 331678006755 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 331678006756 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 331678006757 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 331678006758 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 331678006759 Peptidase family M23; Region: Peptidase_M23; pfam01551 331678006760 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 331678006761 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678006762 NAD(P) binding site [chemical binding]; other site 331678006763 active site 331678006764 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 331678006765 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 331678006766 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 331678006767 O-methyltransferase; Region: Methyltransf_2; pfam00891 331678006768 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 331678006769 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 331678006770 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 331678006771 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 331678006772 L-aspartate oxidase; Provisional; Region: PRK06175 331678006773 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 331678006774 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 331678006775 putative Iron-sulfur protein interface [polypeptide binding]; other site 331678006776 putative proximal heme binding site [chemical binding]; other site 331678006777 putative SdhC-like subunit interface [polypeptide binding]; other site 331678006778 putative distal heme binding site [chemical binding]; other site 331678006779 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 331678006780 putative Iron-sulfur protein interface [polypeptide binding]; other site 331678006781 putative proximal heme binding site [chemical binding]; other site 331678006782 putative SdhD-like interface [polypeptide binding]; other site 331678006783 putative distal heme binding site [chemical binding]; other site 331678006784 cell division protein FtsZ; Validated; Region: PRK09330 331678006785 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 331678006786 nucleotide binding site [chemical binding]; other site 331678006787 SulA interaction site; other site 331678006788 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 331678006789 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 331678006790 nucleotide binding site [chemical binding]; other site 331678006791 Cell division protein FtsA; Region: FtsA; pfam14450 331678006792 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 331678006793 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 331678006794 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 331678006795 FAD binding domain; Region: FAD_binding_4; pfam01565 331678006796 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 331678006797 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 331678006798 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 331678006799 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 331678006800 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 331678006801 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 331678006802 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 331678006803 active site 331678006804 homodimer interface [polypeptide binding]; other site 331678006805 cell division protein FtsW; Region: ftsW; TIGR02614 331678006806 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 331678006807 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 331678006808 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 331678006809 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 331678006810 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 331678006811 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 331678006812 Mg++ binding site [ion binding]; other site 331678006813 putative catalytic motif [active] 331678006814 putative substrate binding site [chemical binding]; other site 331678006815 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 331678006816 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 331678006817 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 331678006818 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 331678006819 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 331678006820 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 331678006821 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 331678006822 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 331678006823 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 331678006824 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 331678006825 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 331678006826 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 331678006827 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 331678006828 MraW methylase family; Region: Methyltransf_5; cl17771 331678006829 cell division protein MraZ; Reviewed; Region: PRK00326 331678006830 MraZ protein; Region: MraZ; pfam02381 331678006831 MraZ protein; Region: MraZ; pfam02381 331678006832 YacP-like NYN domain; Region: NYN_YacP; pfam05991 331678006833 Chorismate mutase type II; Region: CM_2; smart00830 331678006834 YceG-like family; Region: YceG; pfam02618 331678006835 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 331678006836 dimerization interface [polypeptide binding]; other site 331678006837 Phosphoglycerate kinase; Region: PGK; pfam00162 331678006838 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 331678006839 substrate binding site [chemical binding]; other site 331678006840 hinge regions; other site 331678006841 ADP binding site [chemical binding]; other site 331678006842 catalytic site [active] 331678006843 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 331678006844 Uncharacterized conserved protein [Function unknown]; Region: COG3339 331678006845 exonuclease subunit SbcC; Provisional; Region: PRK10246 331678006846 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331678006847 Walker A/P-loop; other site 331678006848 ATP binding site [chemical binding]; other site 331678006849 Q-loop/lid; other site 331678006850 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 331678006851 ABC transporter signature motif; other site 331678006852 Walker B; other site 331678006853 D-loop; other site 331678006854 H-loop/switch region; other site 331678006855 GxxExxY protein; Region: GxxExxY; TIGR04256 331678006856 exonuclease subunit SbcD; Provisional; Region: PRK10966 331678006857 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 331678006858 active site 331678006859 metal binding site [ion binding]; metal-binding site 331678006860 DNA binding site [nucleotide binding] 331678006861 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 331678006862 Protein of unknown function DUF45; Region: DUF45; pfam01863 331678006863 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 331678006864 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 331678006865 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 331678006866 ATP binding site [chemical binding]; other site 331678006867 putative Mg++ binding site [ion binding]; other site 331678006868 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 331678006869 mobile mystery protein B; Region: mob_myst_B; TIGR02613 331678006870 Fic/DOC family; Region: Fic; pfam02661 331678006871 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 331678006872 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 331678006873 motif II; other site 331678006874 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 331678006875 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 331678006876 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 331678006877 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 331678006878 KilA-N domain; Region: KilA-N; pfam04383 331678006879 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 331678006880 HsdM N-terminal domain; Region: HsdM_N; pfam12161 331678006881 Methyltransferase domain; Region: Methyltransf_26; pfam13659 331678006882 GxxExxY protein; Region: GxxExxY; TIGR04256 331678006883 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 331678006884 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 331678006885 putative FMN binding site [chemical binding]; other site 331678006886 NADPH bind site [chemical binding]; other site 331678006887 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 331678006888 putative hydrophobic ligand binding site [chemical binding]; other site 331678006889 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 331678006890 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 331678006891 ATP-grasp domain; Region: ATP-grasp; pfam02222 331678006892 TRAM domain; Region: TRAM; pfam01938 331678006893 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 331678006894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 331678006895 S-adenosylmethionine binding site [chemical binding]; other site 331678006896 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 331678006897 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 331678006898 nucleotide binding site [chemical binding]; other site 331678006899 PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395 331678006900 active site 331678006901 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 331678006902 membrane protein insertase; Provisional; Region: PRK01318 331678006903 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 331678006904 Haemolytic domain; Region: Haemolytic; pfam01809 331678006905 ribonuclease P; Reviewed; Region: rnpA; PRK01903 331678006906 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399