-- dump date   	20140619_041221
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
290317000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
290317000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
290317000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317000004	Walker A motif; other site
290317000005	ATP binding site [chemical binding]; other site
290317000006	Walker B motif; other site
290317000007	arginine finger; other site
290317000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
290317000009	DnaA box-binding interface [nucleotide binding]; other site
290317000010	DNA polymerase III subunit beta; Provisional; Region: PRK14941
290317000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
290317000012	putative DNA binding surface [nucleotide binding]; other site
290317000013	dimer interface [polypeptide binding]; other site
290317000014	beta-clamp/clamp loader binding surface; other site
290317000015	beta-clamp/translesion DNA polymerase binding surface; other site
290317000016	recombination protein F; Reviewed; Region: recF; PRK00064
290317000017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290317000018	Walker A/P-loop; other site
290317000019	ATP binding site [chemical binding]; other site
290317000020	Q-loop/lid; other site
290317000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290317000022	ABC transporter signature motif; other site
290317000023	Walker B; other site
290317000024	D-loop; other site
290317000025	H-loop/switch region; other site
290317000026	Protein of unknown function (DUF721); Region: DUF721; pfam05258
290317000027	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
290317000028	Transposase; Region: DDE_Tnp_ISL3; pfam01610
290317000029	DDE superfamily endonuclease; Region: DDE_3; pfam13358
290317000030	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
290317000031	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
290317000032	Integrase core domain; Region: rve; pfam00665
290317000033	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
290317000034	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317000035	Walker A motif; other site
290317000036	ATP binding site [chemical binding]; other site
290317000037	Walker B motif; other site
290317000038	Winged helix-turn helix; Region: HTH_29; pfam13551
290317000039	Winged helix-turn helix; Region: HTH_33; pfam13592
290317000040	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
290317000041	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
290317000042	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
290317000043	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
290317000044	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
290317000045	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
290317000046	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
290317000047	Transposase; Region: DEDD_Tnp_IS110; pfam01548
290317000048	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
290317000049	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
290317000050	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
290317000051	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
290317000052	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like2_exo; cd05785
290317000053	DNA polymerase type-B family; Region: POLBc; smart00486
290317000054	active site
290317000055	catalytic site [active]
290317000056	substrate binding site [chemical binding]; other site
290317000057	DNA polymerase type-II B subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II_B; cd05538
290317000058	active site
290317000059	metal-binding site
290317000060	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
290317000061	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
290317000062	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
290317000063	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
290317000064	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
290317000065	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
290317000066	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
290317000067	Cytochrome c; Region: Cytochrom_C; cl11414
290317000068	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
290317000069	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
290317000070	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
290317000071	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
290317000072	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
290317000073	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
290317000074	Protein export membrane protein; Region: SecD_SecF; pfam02355
290317000075	SurA N-terminal domain; Region: SurA_N; pfam09312
290317000076	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
290317000077	PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616
290317000078	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
290317000079	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290317000080	ATP binding site [chemical binding]; other site
290317000081	Mg2+ binding site [ion binding]; other site
290317000082	G-X-G motif; other site
290317000083	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
290317000084	anchoring element; other site
290317000085	dimer interface [polypeptide binding]; other site
290317000086	ATP binding site [chemical binding]; other site
290317000087	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
290317000088	active site
290317000089	putative metal-binding site [ion binding]; other site
290317000090	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
290317000091	hypothetical protein; Reviewed; Region: PRK12497
290317000092	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
290317000093	RNA/DNA hybrid binding site [nucleotide binding]; other site
290317000094	active site
290317000095	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
290317000096	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
290317000097	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
290317000098	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
290317000099	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
290317000100	trimer interface [polypeptide binding]; other site
290317000101	active site
290317000102	substrate binding site [chemical binding]; other site
290317000103	CoA binding site [chemical binding]; other site
290317000104	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
290317000105	C-terminal peptidase (prc); Region: prc; TIGR00225
290317000106	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
290317000107	protein binding site [polypeptide binding]; other site
290317000108	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
290317000109	Catalytic dyad [active]
290317000110	Protein of unknown function (DUF2499); Region: DUF2499; pfam10693
290317000111	Protein of unknown function (DUF3593); Region: DUF3593; pfam12159
290317000112	geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023
290317000113	glycyl-tRNA synthetase; Provisional; Region: PRK04173
290317000114	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
290317000115	motif 1; other site
290317000116	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
290317000117	active site
290317000118	motif 2; other site
290317000119	motif 3; other site
290317000120	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
290317000121	anticodon binding site; other site
290317000122	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617
290317000123	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
290317000124	dimer interface [polypeptide binding]; other site
290317000125	catalytic triad [active]
290317000126	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
290317000127	gamma subunit interface [polypeptide binding]; other site
290317000128	epsilon subunit interface [polypeptide binding]; other site
290317000129	LBP interface [polypeptide binding]; other site
290317000130	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
290317000131	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
290317000132	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
290317000133	alpha subunit interaction interface [polypeptide binding]; other site
290317000134	Walker A motif; other site
290317000135	ATP binding site [chemical binding]; other site
290317000136	Walker B motif; other site
290317000137	inhibitor binding site; inhibition site
290317000138	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
290317000139	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
290317000140	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
290317000141	catalytic residues [active]
290317000142	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
290317000143	active site
290317000144	substrate-binding site [chemical binding]; other site
290317000145	metal-binding site [ion binding]
290317000146	GTP binding site [chemical binding]; other site
290317000147	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
290317000148	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
290317000149	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290317000150	ATP binding site [chemical binding]; other site
290317000151	putative Mg++ binding site [ion binding]; other site
290317000152	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
290317000153	nucleotide binding region [chemical binding]; other site
290317000154	ATP-binding site [chemical binding]; other site
290317000155	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
290317000156	HRDC domain; Region: HRDC; pfam00570
290317000157	hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841
290317000158	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
290317000159	putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055
290317000160	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290317000161	FeS/SAM binding site; other site
290317000162	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
290317000163	Astacin (Peptidase family M12A); Region: Astacin; pfam01400
290317000164	Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to...; Region: ZnMc_astacin_like; cd04280
290317000165	active site
290317000166	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
290317000167	TPR motif; other site
290317000168	binding surface
290317000169	CHAT domain; Region: CHAT; pfam12770
290317000170	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782
290317000171	Bacterial SH3 domain; Region: SH3_3; cl17532
290317000172	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
290317000173	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
290317000174	WHG domain; Region: WHG; pfam13305
290317000175	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
290317000176	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
290317000177	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
290317000178	Domain of unknown function (DUF4405); Region: DUF4405; pfam14358
290317000179	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
290317000180	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
290317000181	putative active site [active]
290317000182	putative metal binding site [ion binding]; other site
290317000183	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
290317000184	AAA ATPase domain; Region: AAA_16; pfam13191
290317000185	NACHT domain; Region: NACHT; pfam05729
290317000186	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
290317000187	Uncharacterized conserved protein [Function unknown]; Region: COG1262
290317000188	putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830
290317000189	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
290317000190	non-specific DNA binding site [nucleotide binding]; other site
290317000191	salt bridge; other site
290317000192	sequence-specific DNA binding site [nucleotide binding]; other site
290317000193	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
290317000194	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
290317000195	DNA methylase; Region: N6_N4_Mtase; pfam01555
290317000196	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
290317000197	Integrase core domain; Region: rve; pfam00665
290317000198	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
290317000199	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317000200	Walker A motif; other site
290317000201	ATP binding site [chemical binding]; other site
290317000202	Walker B motif; other site
290317000203	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
290317000204	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290317000205	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290317000206	ATP binding site [chemical binding]; other site
290317000207	Mg2+ binding site [ion binding]; other site
290317000208	G-X-G motif; other site
290317000209	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
290317000210	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
290317000211	cofactor binding site; other site
290317000212	DNA binding site [nucleotide binding]
290317000213	substrate interaction site [chemical binding]; other site
290317000214	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
290317000215	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
290317000216	additional DNA contacts [nucleotide binding]; other site
290317000217	mismatch recognition site; other site
290317000218	active site
290317000219	zinc binding site [ion binding]; other site
290317000220	DNA intercalation site [nucleotide binding]; other site
290317000221	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
290317000222	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
290317000223	salt bridge; other site
290317000224	non-specific DNA binding site [nucleotide binding]; other site
290317000225	sequence-specific DNA binding site [nucleotide binding]; other site
290317000226	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
290317000227	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
290317000228	cofactor binding site; other site
290317000229	DNA binding site [nucleotide binding]
290317000230	substrate interaction site [chemical binding]; other site
290317000231	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
290317000232	AAA domain; Region: AAA_14; pfam13173
290317000233	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
290317000234	putative active site [active]
290317000235	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
290317000236	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
290317000237	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290317000238	H+ Antiporter protein; Region: 2A0121; TIGR00900
290317000239	putative substrate translocation pore; other site
290317000240	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
290317000241	SelR domain; Region: SelR; pfam01641
290317000242	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
290317000243	oligomeric interface; other site
290317000244	putative active site [active]
290317000245	homodimer interface [polypeptide binding]; other site
290317000246	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
290317000247	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
290317000248	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290317000249	putative substrate translocation pore; other site
290317000250	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290317000251	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
290317000252	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
290317000253	HlyD family secretion protein; Region: HlyD_3; pfam13437
290317000254	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
290317000255	Ligand Binding Site [chemical binding]; other site
290317000256	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
290317000257	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
290317000258	GAF domain; Region: GAF; pfam01590
290317000259	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
290317000260	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317000261	Walker A motif; other site
290317000262	ATP binding site [chemical binding]; other site
290317000263	Walker B motif; other site
290317000264	arginine finger; other site
290317000265	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290317000266	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
290317000267	Domain of unknown function DUF21; Region: DUF21; pfam01595
290317000268	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
290317000269	Transporter associated domain; Region: CorC_HlyC; smart01091
290317000270	Conserved oligomeric complex COG6; Region: COG6; pfam06419
290317000271	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
290317000272	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
290317000273	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
290317000274	L-aspartate oxidase; Provisional; Region: PRK06175
290317000275	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
290317000276	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
290317000277	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
290317000278	putative Iron-sulfur protein interface [polypeptide binding]; other site
290317000279	proximal heme binding site [chemical binding]; other site
290317000280	distal heme binding site [chemical binding]; other site
290317000281	putative dimer interface [polypeptide binding]; other site
290317000282	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
290317000283	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
290317000284	nucleotide binding site/active site [active]
290317000285	HIT family signature motif; other site
290317000286	catalytic residue [active]
290317000287	aconitate hydratase; Validated; Region: PRK09277
290317000288	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
290317000289	substrate binding site [chemical binding]; other site
290317000290	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
290317000291	ligand binding site [chemical binding]; other site
290317000292	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
290317000293	substrate binding site [chemical binding]; other site
290317000294	FeoA domain; Region: FeoA; pfam04023
290317000295	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
290317000296	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
290317000297	G1 box; other site
290317000298	GTP/Mg2+ binding site [chemical binding]; other site
290317000299	Switch I region; other site
290317000300	G2 box; other site
290317000301	G3 box; other site
290317000302	Switch II region; other site
290317000303	G4 box; other site
290317000304	G5 box; other site
290317000305	Nucleoside recognition; Region: Gate; pfam07670
290317000306	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
290317000307	Nucleoside recognition; Region: Gate; pfam07670
290317000308	DNA topoisomerase I; Validated; Region: PRK06599
290317000309	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
290317000310	active site
290317000311	interdomain interaction site; other site
290317000312	putative metal-binding site [ion binding]; other site
290317000313	nucleotide binding site [chemical binding]; other site
290317000314	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
290317000315	domain I; other site
290317000316	DNA binding groove [nucleotide binding]
290317000317	phosphate binding site [ion binding]; other site
290317000318	domain II; other site
290317000319	domain III; other site
290317000320	nucleotide binding site [chemical binding]; other site
290317000321	catalytic site [active]
290317000322	domain IV; other site
290317000323	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
290317000324	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
290317000325	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
290317000326	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
290317000327	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
290317000328	active site
290317000329	metal binding site [ion binding]; metal-binding site
290317000330	Biotin operon repressor [Transcription]; Region: BirA; COG1654
290317000331	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
290317000332	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
290317000333	biotin synthase; Region: bioB; TIGR00433
290317000334	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290317000335	FeS/SAM binding site; other site
290317000336	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
290317000337	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
290317000338	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
290317000339	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
290317000340	catalytic residue [active]
290317000341	Protein of unknown function (DUF452); Region: DUF452; cl01062
290317000342	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
290317000343	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290317000344	S-adenosylmethionine binding site [chemical binding]; other site
290317000345	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
290317000346	adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986
290317000347	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
290317000348	inhibitor-cofactor binding pocket; inhibition site
290317000349	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290317000350	catalytic residue [active]
290317000351	Dodecin; Region: Dodecin; pfam07311
290317000352	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
290317000353	4Fe-4S binding domain; Region: Fer4; cl02805
290317000354	4Fe-4S binding domain; Region: Fer4; pfam00037
290317000355	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
290317000356	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
290317000357	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
290317000358	molybdopterin cofactor binding site; other site
290317000359	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
290317000360	putative molybdopterin cofactor binding site; other site
290317000361	Predicted permeases [General function prediction only]; Region: COG0730
290317000362	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
290317000363	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
290317000364	active site residue [active]
290317000365	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
290317000366	CPxP  motif; other site
290317000367	Cobyrinic acid a,c-diamide synthase [Coenzyme metabolism]; Region: CobB; COG1797
290317000368	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
290317000369	catalytic triad [active]
290317000370	DsrC like protein; Region: DsrC; pfam04358
290317000371	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
290317000372	sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064
290317000373	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
290317000374	sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066
290317000375	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
290317000376	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
290317000377	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
290317000378	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
290317000379	DsrE/DsrF-like family; Region: DrsE; cl00672
290317000380	sulfur relay protein TusC/DsrF; Region: sulf_tusC_dsrF; TIGR03010
290317000381	DsrH like protein; Region: DsrH; pfam04077
290317000382	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
290317000383	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
290317000384	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
290317000385	Cysteine-rich domain; Region: CCG; pfam02754
290317000386	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
290317000387	4Fe-4S binding domain; Region: Fer4; cl02805
290317000388	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
290317000389	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
290317000390	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
290317000391	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
290317000392	active site
290317000393	SAM binding site [chemical binding]; other site
290317000394	homodimer interface [polypeptide binding]; other site
290317000395	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
290317000396	active site
290317000397	CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640
290317000398	The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
290317000399	P-loop; other site
290317000400	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
290317000401	NMT1-like family; Region: NMT1_2; pfam13379
290317000402	NMT1/THI5 like; Region: NMT1; pfam09084
290317000403	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
290317000404	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
290317000405	dimer interface [polypeptide binding]; other site
290317000406	conserved gate region; other site
290317000407	putative PBP binding loops; other site
290317000408	ABC-ATPase subunit interface; other site
290317000409	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
290317000410	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
290317000411	Walker A/P-loop; other site
290317000412	ATP binding site [chemical binding]; other site
290317000413	Q-loop/lid; other site
290317000414	ABC transporter signature motif; other site
290317000415	Walker B; other site
290317000416	D-loop; other site
290317000417	H-loop/switch region; other site
290317000418	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
290317000419	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
290317000420	Walker A/P-loop; other site
290317000421	ATP binding site [chemical binding]; other site
290317000422	Q-loop/lid; other site
290317000423	ABC transporter signature motif; other site
290317000424	Walker B; other site
290317000425	D-loop; other site
290317000426	H-loop/switch region; other site
290317000427	Cytochrome c; Region: Cytochrom_C; pfam00034
290317000428	Cytochrome c; Region: Cytochrom_C; pfam00034
290317000429	carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702
290317000430	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
290317000431	ACS interaction site; other site
290317000432	CODH interaction site; other site
290317000433	metal cluster binding site [ion binding]; other site
290317000434	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
290317000435	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
290317000436	homodimer interface [polypeptide binding]; other site
290317000437	metal binding site [ion binding]; metal-binding site
290317000438	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
290317000439	homodimer interface [polypeptide binding]; other site
290317000440	active site
290317000441	putative chemical substrate binding site [chemical binding]; other site
290317000442	metal binding site [ion binding]; metal-binding site
290317000443	short chain dehydrogenase; Provisional; Region: PRK07326
290317000444	classical (c) SDRs; Region: SDR_c; cd05233
290317000445	NAD(P) binding site [chemical binding]; other site
290317000446	active site
290317000447	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
290317000448	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
290317000449	trmE is a tRNA modification GTPase; Region: trmE; cd04164
290317000450	G1 box; other site
290317000451	GTP/Mg2+ binding site [chemical binding]; other site
290317000452	Switch I region; other site
290317000453	G2 box; other site
290317000454	Switch II region; other site
290317000455	G3 box; other site
290317000456	G4 box; other site
290317000457	G5 box; other site
290317000458	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
290317000459	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
290317000460	active site residue [active]
290317000461	Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596
290317000462	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
290317000463	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290317000464	NAD(P) binding site [chemical binding]; other site
290317000465	active site
290317000466	TIR domain; Region: TIR_2; pfam13676
290317000467	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317000468	binding surface
290317000469	TPR motif; other site
290317000470	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
290317000471	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
290317000472	transmembrane helices; other site
290317000473	HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis,    transport, and catabolism]; Region: PaaI; COG2050
290317000474	active site 2 [active]
290317000475	active site 1 [active]
290317000476	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
290317000477	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
290317000478	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
290317000479	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290317000480	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290317000481	ATP binding site [chemical binding]; other site
290317000482	G-X-G motif; other site
290317000483	Response regulator receiver domain; Region: Response_reg; pfam00072
290317000484	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290317000485	active site
290317000486	phosphorylation site [posttranslational modification]
290317000487	intermolecular recognition site; other site
290317000488	dimerization interface [polypeptide binding]; other site
290317000489	Response regulator receiver domain; Region: Response_reg; pfam00072
290317000490	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290317000491	active site
290317000492	phosphorylation site [posttranslational modification]
290317000493	intermolecular recognition site; other site
290317000494	dimerization interface [polypeptide binding]; other site
290317000495	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
290317000496	putative binding surface; other site
290317000497	active site
290317000498	TPR repeat; Region: TPR_11; pfam13414
290317000499	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317000500	binding surface
290317000501	TPR motif; other site
290317000502	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
290317000503	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
290317000504	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
290317000505	NAD(P) binding site [chemical binding]; other site
290317000506	Transglycosylase; Region: Transgly; cl17702
290317000507	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
290317000508	Cytochrome c; Region: Cytochrom_C; pfam00034
290317000509	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
290317000510	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290317000511	ATP binding site [chemical binding]; other site
290317000512	Mg2+ binding site [ion binding]; other site
290317000513	G-X-G motif; other site
290317000514	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
290317000515	ATP binding site [chemical binding]; other site
290317000516	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
290317000517	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
290317000518	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
290317000519	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
290317000520	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
290317000521	Soluble P-type ATPase [General function prediction only]; Region: COG4087
290317000522	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
290317000523	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
290317000524	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
290317000525	substrate binding site [chemical binding]; other site
290317000526	active site
290317000527	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
290317000528	Cysteine-rich domain; Region: CCG; pfam02754
290317000529	Cysteine-rich domain; Region: CCG; pfam02754
290317000530	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
290317000531	Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479
290317000532	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
290317000533	catalytic loop [active]
290317000534	iron binding site [ion binding]; other site
290317000535	L-aspartate oxidase; Provisional; Region: PRK06175
290317000536	succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812
290317000537	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
290317000538	FOG: CBS domain [General function prediction only]; Region: COG0517
290317000539	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
290317000540	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
290317000541	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
290317000542	Protein export membrane protein; Region: SecD_SecF; cl14618
290317000543	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
290317000544	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
290317000545	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
290317000546	putative homodimer interface [polypeptide binding]; other site
290317000547	putative homotetramer interface [polypeptide binding]; other site
290317000548	putative allosteric switch controlling residues; other site
290317000549	putative metal binding site [ion binding]; other site
290317000550	putative homodimer-homodimer interface [polypeptide binding]; other site
290317000551	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
290317000552	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
290317000553	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
290317000554	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
290317000555	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
290317000556	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
290317000557	classical (c) SDRs; Region: SDR_c; cd05233
290317000558	NAD(P) binding site [chemical binding]; other site
290317000559	active site
290317000560	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
290317000561	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
290317000562	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
290317000563	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
290317000564	putative active site; other site
290317000565	catalytic residue [active]
290317000566	short chain dehydrogenase; Validated; Region: PRK08324
290317000567	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
290317000568	active site
290317000569	Zn2+ binding site [ion binding]; other site
290317000570	intersubunit interface [polypeptide binding]; other site
290317000571	rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943
290317000572	putative NAD(P) binding site [chemical binding]; other site
290317000573	active site
290317000574	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
290317000575	2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284
290317000576	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
290317000577	B12 binding site [chemical binding]; other site
290317000578	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
290317000579	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
290317000580	Flavodoxin domain; Region: Flavodoxin_5; cl17428
290317000581	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
290317000582	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
290317000583	Phosphotransferase enzyme family; Region: APH; pfam01636
290317000584	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
290317000585	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
290317000586	Substrate binding site; other site
290317000587	metal-binding site
290317000588	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
290317000589	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
290317000590	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493
290317000591	Na binding site [ion binding]; other site
290317000592	Bacteriochlorophyll C binding protein; Region: Bac_chlorC; pfam02043
290317000593	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
290317000594	NADH(P)-binding; Region: NAD_binding_10; pfam13460
290317000595	NAD(P) binding site [chemical binding]; other site
290317000596	putative active site [active]
290317000597	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
290317000598	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
290317000599	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
290317000600	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
290317000601	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
290317000602	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
290317000603	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
290317000604	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
290317000605	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
290317000606	P loop; other site
290317000607	Nucleotide binding site [chemical binding]; other site
290317000608	DTAP/Switch II; other site
290317000609	Switch I; other site
290317000610	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317000611	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
290317000612	binding surface
290317000613	TPR motif; other site
290317000614	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317000615	binding surface
290317000616	TPR motif; other site
290317000617	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317000618	binding surface
290317000619	TPR motif; other site
290317000620	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
290317000621	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
290317000622	Rubredoxin [Energy production and conversion]; Region: COG1773
290317000623	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
290317000624	iron binding site [ion binding]; other site
290317000625	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
290317000626	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
290317000627	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
290317000628	Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224
290317000629	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
290317000630	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
290317000631	Ligand binding site; other site
290317000632	Putative Catalytic site; other site
290317000633	DXD motif; other site
290317000634	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
290317000635	elongation factor G; Reviewed; Region: PRK12740
290317000636	G1 box; other site
290317000637	putative GEF interaction site [polypeptide binding]; other site
290317000638	GTP/Mg2+ binding site [chemical binding]; other site
290317000639	Switch I region; other site
290317000640	G2 box; other site
290317000641	G3 box; other site
290317000642	Switch II region; other site
290317000643	G4 box; other site
290317000644	G5 box; other site
290317000645	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
290317000646	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
290317000647	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
290317000648	enolase; Provisional; Region: eno; PRK00077
290317000649	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
290317000650	dimer interface [polypeptide binding]; other site
290317000651	metal binding site [ion binding]; metal-binding site
290317000652	substrate binding pocket [chemical binding]; other site
290317000653	Septum formation initiator; Region: DivIC; cl17659
290317000654	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
290317000655	GcpE protein; Region: GcpE; pfam04551
290317000656	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
290317000657	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
290317000658	classical (c) SDRs; Region: SDR_c; cd05233
290317000659	NAD(P) binding site [chemical binding]; other site
290317000660	active site
290317000661	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
290317000662	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
290317000663	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
290317000664	putative homodimer interface [polypeptide binding]; other site
290317000665	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
290317000666	heterodimer interface [polypeptide binding]; other site
290317000667	homodimer interface [polypeptide binding]; other site
290317000668	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
290317000669	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
290317000670	23S rRNA interface [nucleotide binding]; other site
290317000671	L7/L12 interface [polypeptide binding]; other site
290317000672	putative thiostrepton binding site; other site
290317000673	L25 interface [polypeptide binding]; other site
290317000674	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
290317000675	mRNA/rRNA interface [nucleotide binding]; other site
290317000676	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
290317000677	23S rRNA interface [nucleotide binding]; other site
290317000678	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
290317000679	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
290317000680	core dimer interface [polypeptide binding]; other site
290317000681	peripheral dimer interface [polypeptide binding]; other site
290317000682	L10 interface [polypeptide binding]; other site
290317000683	L11 interface [polypeptide binding]; other site
290317000684	putative EF-Tu interaction site [polypeptide binding]; other site
290317000685	putative EF-G interaction site [polypeptide binding]; other site
290317000686	RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563
290317000687	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
290317000688	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
290317000689	RPB12 interaction site [polypeptide binding]; other site
290317000690	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
290317000691	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
290317000692	RPB3 interaction site [polypeptide binding]; other site
290317000693	RPB1 interaction site [polypeptide binding]; other site
290317000694	RPB11 interaction site [polypeptide binding]; other site
290317000695	RPB10 interaction site [polypeptide binding]; other site
290317000696	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
290317000697	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
290317000698	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
290317000699	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
290317000700	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
290317000701	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
290317000702	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
290317000703	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
290317000704	DNA binding site [nucleotide binding]
290317000705	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
290317000706	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
290317000707	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
290317000708	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
290317000709	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
290317000710	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
290317000711	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
290317000712	carboxyltransferase (CT) interaction site; other site
290317000713	biotinylation site [posttranslational modification]; other site
290317000714	elongation factor P; Validated; Region: PRK00529
290317000715	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
290317000716	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
290317000717	RNA binding site [nucleotide binding]; other site
290317000718	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
290317000719	RNA binding site [nucleotide binding]; other site
290317000720	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
290317000721	IHF - DNA interface [nucleotide binding]; other site
290317000722	IHF dimer interface [polypeptide binding]; other site
290317000723	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
290317000724	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
290317000725	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
290317000726	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
290317000727	TPP-binding site [chemical binding]; other site
290317000728	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
290317000729	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
290317000730	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
290317000731	dimer interface [polypeptide binding]; other site
290317000732	PYR/PP interface [polypeptide binding]; other site
290317000733	TPP binding site [chemical binding]; other site
290317000734	substrate binding site [chemical binding]; other site
290317000735	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
290317000736	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
290317000737	motif 1; other site
290317000738	active site
290317000739	motif 2; other site
290317000740	motif 3; other site
290317000741	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
290317000742	DHHA1 domain; Region: DHHA1; pfam02272
290317000743	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
290317000744	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
290317000745	Ferredoxin [Energy production and conversion]; Region: COG1146
290317000746	Ferredoxin [Energy production and conversion]; Region: COG1146
290317000747	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
290317000748	HipA-like N-terminal domain; Region: HipA_N; pfam07805
290317000749	HipA-like C-terminal domain; Region: HipA_C; pfam07804
290317000750	HipA N-terminal domain; Region: couple_hipA; TIGR03071
290317000751	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
290317000752	non-specific DNA binding site [nucleotide binding]; other site
290317000753	salt bridge; other site
290317000754	sequence-specific DNA binding site [nucleotide binding]; other site
290317000755	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
290317000756	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
290317000757	phosphoserine phosphatase SerB; Region: serB; TIGR00338
290317000758	Acid Phosphatase; Region: Acid_PPase; cl17256
290317000759	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
290317000760	motif II; other site
290317000761	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483
290317000762	Putative addiction module component; Region: Unstab_antitox; pfam09720
290317000763	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
290317000764	Transposase; Region: DDE_Tnp_ISL3; pfam01610
290317000765	Transposase IS200 like; Region: Y1_Tnp; cl00848
290317000766	integron integrase; Region: integrase_gron; TIGR02249
290317000767	IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193
290317000768	Int/Topo IB signature motif; other site
290317000769	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
290317000770	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
290317000771	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
290317000772	Glucuronate isomerase; Region: UxaC; cl00829
290317000773	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
290317000774	HNH endonuclease; Region: HNH_5; pfam14279
290317000775	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
290317000776	Integrase core domain; Region: rve; pfam00665
290317000777	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
290317000778	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317000779	Walker A motif; other site
290317000780	ATP binding site [chemical binding]; other site
290317000781	Walker B motif; other site
290317000782	TIR domain; Region: TIR_2; pfam13676
290317000783	CAAX protease self-immunity; Region: Abi; pfam02517
290317000784	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
290317000785	dimer interface [polypeptide binding]; other site
290317000786	[2Fe-2S] cluster binding site [ion binding]; other site
290317000787	Predicted nucleotidyltransferase [General function prediction    only]; Region: COG4849
290317000788	Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952
290317000789	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
290317000790	Protein of unknown function (DUF497); Region: DUF497; cl01108
290317000791	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
290317000792	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
290317000793	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304
290317000794	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780
290317000795	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
290317000796	active site
290317000797	NTP binding site [chemical binding]; other site
290317000798	metal binding triad [ion binding]; metal-binding site
290317000799	antibiotic binding site [chemical binding]; other site
290317000800	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
290317000801	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
290317000802	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
290317000803	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
290317000804	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
290317000805	motif II; other site
290317000806	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
290317000807	AAA ATPase domain; Region: AAA_16; pfam13191
290317000808	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
290317000809	MarR family; Region: MarR_2; cl17246
290317000810	TPR repeat; Region: TPR_11; pfam13414
290317000811	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317000812	binding surface
290317000813	TPR motif; other site
290317000814	TPR repeat; Region: TPR_11; pfam13414
290317000815	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317000816	binding surface
290317000817	TPR motif; other site
290317000818	AAA ATPase domain; Region: AAA_16; pfam13191
290317000819	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317000820	Walker A motif; other site
290317000821	ATP binding site [chemical binding]; other site
290317000822	Walker B motif; other site
290317000823	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
290317000824	AAA domain; Region: AAA_12; pfam13087
290317000825	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
290317000826	GMP synthase; Reviewed; Region: guaA; PRK00074
290317000827	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
290317000828	AMP/PPi binding site [chemical binding]; other site
290317000829	candidate oxyanion hole; other site
290317000830	catalytic triad [active]
290317000831	potential glutamine specificity residues [chemical binding]; other site
290317000832	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
290317000833	ATP Binding subdomain [chemical binding]; other site
290317000834	Ligand Binding sites [chemical binding]; other site
290317000835	Dimerization subdomain; other site
290317000836	Transglycosylase; Region: Transgly; pfam00912
290317000837	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
290317000838	N-terminal Mad Homology 1 (MH1) domain; Region: MH1; cl00055
290317000839	DNA binding site [nucleotide binding]
290317000840	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
290317000841	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
290317000842	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
290317000843	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
290317000844	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
290317000845	Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978
290317000846	C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733
290317000847	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
290317000848	hydroxyglutarate oxidase; Provisional; Region: PRK11728
290317000849	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
290317000850	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
290317000851	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
290317000852	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
290317000853	Cytochrome c [Energy production and conversion]; Region: COG3258
290317000854	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
290317000855	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
290317000856	putative NAD(P) binding site [chemical binding]; other site
290317000857	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
290317000858	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
290317000859	catalytic triad [active]
290317000860	Predicted ATPase [General function prediction only]; Region: COG3911
290317000861	AAA domain; Region: AAA_28; pfam13521
290317000862	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
290317000863	metal binding site 2 [ion binding]; metal-binding site
290317000864	putative DNA binding helix; other site
290317000865	metal binding site 1 [ion binding]; metal-binding site
290317000866	dimer interface [polypeptide binding]; other site
290317000867	structural Zn2+ binding site [ion binding]; other site
290317000868	Protein of unknown function (DUF3793); Region: DUF3793; pfam12672
290317000869	FeoA domain; Region: FeoA; pfam04023
290317000870	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
290317000871	G1 box; other site
290317000872	GTP/Mg2+ binding site [chemical binding]; other site
290317000873	Homeodomain-like domain; Region: HTH_23; pfam13384
290317000874	Winged helix-turn helix; Region: HTH_29; pfam13551
290317000875	Winged helix-turn helix; Region: HTH_33; pfam13592
290317000876	DDE superfamily endonuclease; Region: DDE_3; pfam13358
290317000877	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
290317000878	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
290317000879	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
290317000880	Switch I region; other site
290317000881	G2 box; other site
290317000882	G3 box; other site
290317000883	Switch II region; other site
290317000884	GTP/Mg2+ binding site [chemical binding]; other site
290317000885	G4 box; other site
290317000886	G5 box; other site
290317000887	Nucleoside recognition; Region: Gate; pfam07670
290317000888	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
290317000889	FeoC like transcriptional regulator; Region: FeoC; pfam09012
290317000890	flavodoxin FldA; Validated; Region: PRK09267
290317000891	Transposase [DNA replication, recombination, and repair]; Region: COG5421
290317000892	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
290317000893	Integrase core domain; Region: rve; pfam00665
290317000894	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
290317000895	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317000896	Walker A motif; other site
290317000897	ATP binding site [chemical binding]; other site
290317000898	Walker B motif; other site
290317000899	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
290317000900	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
290317000901	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
290317000902	Clp amino terminal domain; Region: Clp_N; pfam02861
290317000903	Clp amino terminal domain; Region: Clp_N; pfam02861
290317000904	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317000905	Walker A motif; other site
290317000906	ATP binding site [chemical binding]; other site
290317000907	Walker B motif; other site
290317000908	arginine finger; other site
290317000909	UvrB/uvrC motif; Region: UVR; pfam02151
290317000910	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317000911	Walker A motif; other site
290317000912	ATP binding site [chemical binding]; other site
290317000913	Walker B motif; other site
290317000914	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
290317000915	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
290317000916	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
290317000917	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290317000918	catalytic residue [active]
290317000919	thiamine monophosphate kinase; Provisional; Region: PRK05731
290317000920	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
290317000921	ATP binding site [chemical binding]; other site
290317000922	dimerization interface [polypeptide binding]; other site
290317000923	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
290317000924	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
290317000925	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
290317000926	P loop; other site
290317000927	GTP binding site [chemical binding]; other site
290317000928	GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441
290317000929	GIY-YIG motif/motif A; other site
290317000930	putative active site [active]
290317000931	putative metal binding site [ion binding]; other site
290317000932	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
290317000933	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290317000934	S-adenosylmethionine binding site [chemical binding]; other site
290317000935	SurA N-terminal domain; Region: SurA_N_3; cl07813
290317000936	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
290317000937	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
290317000938	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
290317000939	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
290317000940	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
290317000941	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
290317000942	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
290317000943	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
290317000944	replicative DNA helicase; Region: DnaB; TIGR00665
290317000945	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
290317000946	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
290317000947	Walker A motif; other site
290317000948	ATP binding site [chemical binding]; other site
290317000949	Walker B motif; other site
290317000950	DNA binding loops [nucleotide binding]
290317000951	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
290317000952	Fe-S cluster binding site [ion binding]; other site
290317000953	active site
290317000954	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
290317000955	Flavoprotein; Region: Flavoprotein; pfam02441
290317000956	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
290317000957	Family of unknown function (DUF490); Region: DUF490; pfam04357
290317000958	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
290317000959	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
290317000960	active site
290317000961	HIGH motif; other site
290317000962	nucleotide binding site [chemical binding]; other site
290317000963	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
290317000964	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
290317000965	putative acyl-acceptor binding pocket; other site
290317000966	Predicted membrane protein [Function unknown]; Region: COG2246
290317000967	GtrA-like protein; Region: GtrA; pfam04138
290317000968	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
290317000969	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
290317000970	Ligand binding site; other site
290317000971	Putative Catalytic site; other site
290317000972	DXD motif; other site
290317000973	Methyltransferase domain; Region: Methyltransf_24; pfam13578
290317000974	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
290317000975	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
290317000976	Probable Catalytic site; other site
290317000977	metal-binding site
290317000978	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
290317000979	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
290317000980	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
290317000981	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
290317000982	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
290317000983	Walker A/P-loop; other site
290317000984	ATP binding site [chemical binding]; other site
290317000985	Q-loop/lid; other site
290317000986	ABC transporter signature motif; other site
290317000987	Walker B; other site
290317000988	D-loop; other site
290317000989	H-loop/switch region; other site
290317000990	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
290317000991	Probable Catalytic site; other site
290317000992	metal-binding site
290317000993	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
290317000994	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
290317000995	Probable Catalytic site; other site
290317000996	metal-binding site
290317000997	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290317000998	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
290317000999	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
290317001000	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
290317001001	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
290317001002	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
290317001003	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290317001004	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290317001005	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
290317001006	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290317001007	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
290317001008	putative ADP-binding pocket [chemical binding]; other site
290317001009	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
290317001010	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
290317001011	putative active site [active]
290317001012	CAAX protease self-immunity; Region: Abi; pfam02517
290317001013	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
290317001014	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
290317001015	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
290317001016	active site
290317001017	phosphorylation site [posttranslational modification]
290317001018	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
290317001019	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
290317001020	dimer interface [polypeptide binding]; other site
290317001021	motif 1; other site
290317001022	active site
290317001023	motif 2; other site
290317001024	motif 3; other site
290317001025	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
290317001026	anticodon binding site; other site
290317001027	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
290317001028	ribosome maturation protein RimP; Reviewed; Region: PRK00092
290317001029	hypothetical protein; Provisional; Region: PRK14641
290317001030	NusA N-terminal domain; Region: NusA_N; pfam08529
290317001031	transcription termination factor NusA; Region: NusA; TIGR01953
290317001032	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
290317001033	RNA binding site [nucleotide binding]; other site
290317001034	homodimer interface [polypeptide binding]; other site
290317001035	NusA-like KH domain; Region: KH_5; pfam13184
290317001036	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
290317001037	G-X-X-G motif; other site
290317001038	cell division protein DamX; Validated; Region: PRK10905
290317001039	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
290317001040	translation initiation factor IF-2; Region: IF-2; TIGR00487
290317001041	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
290317001042	G1 box; other site
290317001043	putative GEF interaction site [polypeptide binding]; other site
290317001044	GTP/Mg2+ binding site [chemical binding]; other site
290317001045	Switch I region; other site
290317001046	G2 box; other site
290317001047	G3 box; other site
290317001048	Switch II region; other site
290317001049	G4 box; other site
290317001050	G5 box; other site
290317001051	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
290317001052	Translation-initiation factor 2; Region: IF-2; pfam11987
290317001053	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
290317001054	Ribosome-binding factor A; Region: RBFA; pfam02033
290317001055	tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431
290317001056	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
290317001057	active site
290317001058	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
290317001059	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
290317001060	active site
290317001061	Riboflavin kinase; Region: Flavokinase; pfam01687
290317001062	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
290317001063	16S/18S rRNA binding site [nucleotide binding]; other site
290317001064	S13e-L30e interaction site [polypeptide binding]; other site
290317001065	25S rRNA binding site [nucleotide binding]; other site
290317001066	hypothetical protein; Provisional; Region: PRK11820
290317001067	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
290317001068	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
290317001069	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
290317001070	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
290317001071	catalytic site [active]
290317001072	G-X2-G-X-G-K; other site
290317001073	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
290317001074	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
290317001075	active site
290317001076	metal binding site [ion binding]; metal-binding site
290317001077	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
290317001078	Substrate binding site; other site
290317001079	Mg++ binding site; other site
290317001080	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
290317001081	tetramerization interface [polypeptide binding]; other site
290317001082	active site
290317001083	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
290317001084	periplasmic chaperone; Provisional; Region: PRK10780
290317001085	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
290317001086	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
290317001087	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
290317001088	DNA protecting protein DprA; Region: dprA; TIGR00732
290317001089	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
290317001090	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
290317001091	substrate binding pocket [chemical binding]; other site
290317001092	chain length determination region; other site
290317001093	substrate-Mg2+ binding site; other site
290317001094	catalytic residues [active]
290317001095	aspartate-rich region 1; other site
290317001096	active site lid residues [active]
290317001097	aspartate-rich region 2; other site
290317001098	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
290317001099	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
290317001100	homotetramer interface [polypeptide binding]; other site
290317001101	FMN binding site [chemical binding]; other site
290317001102	homodimer contacts [polypeptide binding]; other site
290317001103	putative active site [active]
290317001104	putative substrate binding site [chemical binding]; other site
290317001105	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
290317001106	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
290317001107	FtsX-like permease family; Region: FtsX; pfam02687
290317001108	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
290317001109	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
290317001110	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
290317001111	Walker A/P-loop; other site
290317001112	ATP binding site [chemical binding]; other site
290317001113	Q-loop/lid; other site
290317001114	ABC transporter signature motif; other site
290317001115	Walker B; other site
290317001116	D-loop; other site
290317001117	H-loop/switch region; other site
290317001118	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
290317001119	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
290317001120	active site
290317001121	substrate binding site [chemical binding]; other site
290317001122	metal binding site [ion binding]; metal-binding site
290317001123	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
290317001124	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
290317001125	RuvA N terminal domain; Region: RuvA_N; pfam01330
290317001126	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
290317001127	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
290317001128	transcription termination factor Rho; Provisional; Region: rho; PRK09376
290317001129	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
290317001130	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
290317001131	RNA binding site [nucleotide binding]; other site
290317001132	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
290317001133	multimer interface [polypeptide binding]; other site
290317001134	Walker A motif; other site
290317001135	ATP binding site [chemical binding]; other site
290317001136	Walker B motif; other site
290317001137	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
290317001138	Bifunctional nuclease; Region: DNase-RNase; pfam02577
290317001139	UvrB/uvrC motif; Region: UVR; pfam02151
290317001140	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
290317001141	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
290317001142	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
290317001143	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
290317001144	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
290317001145	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
290317001146	Surface antigen; Region: Bac_surface_Ag; pfam01103
290317001147	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
290317001148	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
290317001149	catalytic residue [active]
290317001150	putative FPP diphosphate  binding site; other site
290317001151	putative FPP binding hydrophobic cleft; other site
290317001152	dimer interface [polypeptide binding]; other site
290317001153	putative IPP diphosphate binding site; other site
290317001154	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
290317001155	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
290317001156	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
290317001157	CoA binding domain; Region: CoA_binding; smart00881
290317001158	CoA-ligase; Region: Ligase_CoA; pfam00549
290317001159	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
290317001160	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
290317001161	putative active site [active]
290317001162	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
290317001163	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
290317001164	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
290317001165	Heavy-metal resistance; Region: Metal_resist; pfam13801
290317001166	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
290317001167	dimer interface [polypeptide binding]; other site
290317001168	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
290317001169	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
290317001170	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
290317001171	DNA binding residues [nucleotide binding]
290317001172	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
290317001173	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
290317001174	active site
290317001175	substrate binding site [chemical binding]; other site
290317001176	metal binding site [ion binding]; metal-binding site
290317001177	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
290317001178	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
290317001179	putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814
290317001180	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
290317001181	catalytic loop [active]
290317001182	iron binding site [ion binding]; other site
290317001183	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
290317001184	LytB protein; Region: LYTB; cl00507
290317001185	glutamate racemase; Provisional; Region: PRK00865
290317001186	GTP-binding protein YchF; Reviewed; Region: PRK09601
290317001187	YchF GTPase; Region: YchF; cd01900
290317001188	G1 box; other site
290317001189	GTP/Mg2+ binding site [chemical binding]; other site
290317001190	Switch I region; other site
290317001191	G2 box; other site
290317001192	Switch II region; other site
290317001193	G3 box; other site
290317001194	G4 box; other site
290317001195	G5 box; other site
290317001196	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
290317001197	cytidylate kinase; Provisional; Region: cmk; PRK00023
290317001198	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
290317001199	CMP-binding site; other site
290317001200	The sites determining sugar specificity; other site
290317001201	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
290317001202	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
290317001203	RNA binding site [nucleotide binding]; other site
290317001204	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
290317001205	RNA binding site [nucleotide binding]; other site
290317001206	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
290317001207	RNA binding site [nucleotide binding]; other site
290317001208	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
290317001209	RNA binding site [nucleotide binding]; other site
290317001210	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
290317001211	RNA binding site [nucleotide binding]; other site
290317001212	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164
290317001213	RNA binding site [nucleotide binding]; other site
290317001214	GTPase Era; Reviewed; Region: era; PRK00089
290317001215	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
290317001216	G1 box; other site
290317001217	GTP/Mg2+ binding site [chemical binding]; other site
290317001218	Switch I region; other site
290317001219	G2 box; other site
290317001220	Switch II region; other site
290317001221	G3 box; other site
290317001222	G4 box; other site
290317001223	G5 box; other site
290317001224	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
290317001225	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
290317001226	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
290317001227	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290317001228	FeS/SAM binding site; other site
290317001229	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
290317001230	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
290317001231	IHF dimer interface [polypeptide binding]; other site
290317001232	IHF - DNA interface [nucleotide binding]; other site
290317001233	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
290317001234	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317001235	Walker B motif; other site
290317001236	arginine finger; other site
290317001237	Peptidase family M41; Region: Peptidase_M41; pfam01434
290317001238	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
290317001239	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
290317001240	HIGH motif; other site
290317001241	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
290317001242	active site
290317001243	KMSKS motif; other site
290317001244	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
290317001245	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
290317001246	iron-sulfur cluster [ion binding]; other site
290317001247	[2Fe-2S] cluster binding site [ion binding]; other site
290317001248	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
290317001249	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
290317001250	intrachain domain interface; other site
290317001251	interchain domain interface [polypeptide binding]; other site
290317001252	heme bH binding site [chemical binding]; other site
290317001253	heme bL binding site [chemical binding]; other site
290317001254	Qo binding site; other site
290317001255	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
290317001256	intrachain domain interface; other site
290317001257	Qi binding site; other site
290317001258	interchain domain interface [polypeptide binding]; other site
290317001259	Qo binding site; other site
290317001260	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
290317001261	active site
290317001262	catalytic site [active]
290317001263	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
290317001264	classical (c) SDRs; Region: SDR_c; cd05233
290317001265	NAD(P) binding site [chemical binding]; other site
290317001266	active site
290317001267	molybdenum-pterin binding domain; Region: Mop; TIGR00638
290317001268	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
290317001269	Transcriptional regulator [Transcription]; Region: LysR; COG0583
290317001270	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
290317001271	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
290317001272	dimerization interface [polypeptide binding]; other site
290317001273	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
290317001274	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
290317001275	Walker A/P-loop; other site
290317001276	ATP binding site [chemical binding]; other site
290317001277	Q-loop/lid; other site
290317001278	ABC transporter signature motif; other site
290317001279	Walker B; other site
290317001280	D-loop; other site
290317001281	H-loop/switch region; other site
290317001282	TOBE domain; Region: TOBE; cl01440
290317001283	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
290317001284	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
290317001285	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
290317001286	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
290317001287	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
290317001288	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
290317001289	dimer interface [polypeptide binding]; other site
290317001290	conserved gate region; other site
290317001291	putative PBP binding loops; other site
290317001292	ABC-ATPase subunit interface; other site
290317001293	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
290317001294	active site
290317001295	SAM binding site [chemical binding]; other site
290317001296	homodimer interface [polypeptide binding]; other site
290317001297	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
290317001298	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
290317001299	N-terminal plug; other site
290317001300	ligand-binding site [chemical binding]; other site
290317001301	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
290317001302	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
290317001303	dimer interface [polypeptide binding]; other site
290317001304	putative PBP binding regions; other site
290317001305	ABC-ATPase subunit  interface; other site
290317001306	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
290317001307	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
290317001308	Walker A/P-loop; other site
290317001309	ATP binding site [chemical binding]; other site
290317001310	Q-loop/lid; other site
290317001311	ABC transporter signature motif; other site
290317001312	Walker B; other site
290317001313	D-loop; other site
290317001314	H-loop/switch region; other site
290317001315	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290317001316	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
290317001317	Periplasmic binding protein TroA_e.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142
290317001318	putative ligand binding residues [chemical binding]; other site
290317001319	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
290317001320	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
290317001321	Moco binding site; other site
290317001322	Cytochrome c; Region: Cytochrom_C; cl11414
290317001323	Cytochrome c; Region: Cytochrom_C; pfam00034
290317001324	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290317001325	molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142
290317001326	Walker A/P-loop; other site
290317001327	ATP binding site [chemical binding]; other site
290317001328	Q-loop/lid; other site
290317001329	ABC transporter signature motif; other site
290317001330	Walker B; other site
290317001331	D-loop; other site
290317001332	H-loop/switch region; other site
290317001333	TOBE domain; Region: TOBE; cl01440
290317001334	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
290317001335	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
290317001336	putative PBP binding loops; other site
290317001337	ABC-ATPase subunit interface; other site
290317001338	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
290317001339	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
290317001340	molybdenum transport protein ModD; Provisional; Region: PRK06096
290317001341	ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573
290317001342	dimerization interface [polypeptide binding]; other site
290317001343	active site
290317001344	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
290317001345	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
290317001346	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290317001347	NACHT domain; Region: NACHT; pfam05729
290317001348	Walker A/P-loop; other site
290317001349	ATP binding site [chemical binding]; other site
290317001350	Q-loop/lid; other site
290317001351	ABC transporter signature motif; other site
290317001352	Walker B; other site
290317001353	D-loop; other site
290317001354	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
290317001355	Uncharacterized conserved protein [Function unknown]; Region: COG1262
290317001356	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
290317001357	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
290317001358	putative active site [active]
290317001359	putative NTP binding site [chemical binding]; other site
290317001360	putative nucleic acid binding site [nucleotide binding]; other site
290317001361	NACHT domain; Region: NACHT; pfam05729
290317001362	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
290317001363	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
290317001364	Uncharacterized conserved protein [Function unknown]; Region: COG1262
290317001365	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
290317001366	dimerization interface [polypeptide binding]; other site
290317001367	putative DNA binding site [nucleotide binding]; other site
290317001368	putative Zn2+ binding site [ion binding]; other site
290317001369	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
290317001370	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
290317001371	active site residue [active]
290317001372	Predicted permeases [General function prediction only]; Region: COG0701
290317001373	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
290317001374	Low molecular weight phosphatase family; Region: LMWPc; cd00115
290317001375	active site
290317001376	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
290317001377	arsenical-resistance protein; Region: acr3; TIGR00832
290317001378	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
290317001379	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
290317001380	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
290317001381	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
290317001382	catalytic residues [active]
290317001383	Flagellin N-methylase; Region: FliB; pfam03692
290317001384	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
290317001385	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
290317001386	Walker A/P-loop; other site
290317001387	ATP binding site [chemical binding]; other site
290317001388	Q-loop/lid; other site
290317001389	ABC transporter signature motif; other site
290317001390	Walker B; other site
290317001391	D-loop; other site
290317001392	H-loop/switch region; other site
290317001393	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
290317001394	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
290317001395	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
290317001396	nucleotide binding pocket [chemical binding]; other site
290317001397	K-X-D-G motif; other site
290317001398	catalytic site [active]
290317001399	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
290317001400	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
290317001401	Helix-hairpin-helix motif; Region: HHH; pfam00633
290317001402	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
290317001403	Predicted integral membrane protein [Function unknown]; Region: COG5652
290317001404	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
290317001405	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290317001406	S-adenosylmethionine binding site [chemical binding]; other site
290317001407	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
290317001408	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
290317001409	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
290317001410	HlyD family secretion protein; Region: HlyD_3; pfam13437
290317001411	Ferrochelatase; Region: Ferrochelatase; pfam00762
290317001412	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
290317001413	C-terminal domain interface [polypeptide binding]; other site
290317001414	active site
290317001415	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
290317001416	active site
290317001417	N-terminal domain interface [polypeptide binding]; other site
290317001418	Uncharacterized conserved protein [Function unknown]; Region: COG1432
290317001419	LabA_like proteins; Region: LabA; cd10911
290317001420	putative metal binding site [ion binding]; other site
290317001421	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
290317001422	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
290317001423	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
290317001424	Walker A/P-loop; other site
290317001425	ATP binding site [chemical binding]; other site
290317001426	Q-loop/lid; other site
290317001427	ABC transporter signature motif; other site
290317001428	Walker B; other site
290317001429	D-loop; other site
290317001430	H-loop/switch region; other site
290317001431	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
290317001432	cobalt transport protein CbiM; Validated; Region: PRK06265
290317001433	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
290317001434	PDGLE domain; Region: PDGLE; pfam13190
290317001435	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
290317001436	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
290317001437	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
290317001438	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
290317001439	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
290317001440	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
290317001441	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
290317001442	FAD binding pocket [chemical binding]; other site
290317001443	FAD binding motif [chemical binding]; other site
290317001444	phosphate binding motif [ion binding]; other site
290317001445	beta-alpha-beta structure motif; other site
290317001446	NAD binding pocket [chemical binding]; other site
290317001447	Iron coordination center [ion binding]; other site
290317001448	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181
290317001449	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
290317001450	putative active site [active]
290317001451	oxyanion strand; other site
290317001452	catalytic triad [active]
290317001453	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
290317001454	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
290317001455	catalytic residues [active]
290317001456	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
290317001457	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
290317001458	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
290317001459	RNA binding surface [nucleotide binding]; other site
290317001460	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
290317001461	active site
290317001462	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
290317001463	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
290317001464	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
290317001465	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
290317001466	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
290317001467	aminodeoxychorismate synthase; Provisional; Region: PRK07508
290317001468	chorismate binding enzyme; Region: Chorismate_bind; cl10555
290317001469	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
290317001470	homodimer interface [polypeptide binding]; other site
290317001471	substrate-cofactor binding pocket; other site
290317001472	Aminotransferase class IV; Region: Aminotran_4; pfam01063
290317001473	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290317001474	catalytic residue [active]
290317001475	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
290317001476	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
290317001477	helix-hairpin-helix signature motif; other site
290317001478	substrate binding pocket [chemical binding]; other site
290317001479	active site
290317001480	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
290317001481	transcription antitermination factor NusB; Region: nusB; TIGR01951
290317001482	putative RNA binding site [nucleotide binding]; other site
290317001483	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
290317001484	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
290317001485	motif II; other site
290317001486	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
290317001487	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
290317001488	Walker A/P-loop; other site
290317001489	ATP binding site [chemical binding]; other site
290317001490	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
290317001491	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
290317001492	ABC transporter signature motif; other site
290317001493	Walker B; other site
290317001494	D-loop; other site
290317001495	H-loop/switch region; other site
290317001496	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
290317001497	dihydropteroate synthase; Region: DHPS; TIGR01496
290317001498	substrate binding pocket [chemical binding]; other site
290317001499	dimer interface [polypeptide binding]; other site
290317001500	inhibitor binding site; inhibition site
290317001501	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
290317001502	Peptidase family M50; Region: Peptidase_M50; pfam02163
290317001503	active site
290317001504	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
290317001505	putative substrate binding region [chemical binding]; other site
290317001506	Haem-binding domain; Region: Haem_bd; pfam14376
290317001507	Methyltransferase domain; Region: Methyltransf_25; pfam13649
290317001508	Predicted transcriptional regulator [Transcription]; Region: COG1959
290317001509	Transcriptional regulator; Region: Rrf2; pfam02082
290317001510	4Fe-4S binding domain; Region: Fer4_6; pfam12837
290317001511	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
290317001512	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317001513	TPR motif; other site
290317001514	binding surface
290317001515	hybrid cluster protein; Provisional; Region: PRK05290
290317001516	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
290317001517	ACS interaction site; other site
290317001518	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
290317001519	hybrid metal cluster; other site
290317001520	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
290317001521	active site
290317001522	8-oxo-dGMP binding site [chemical binding]; other site
290317001523	nudix motif; other site
290317001524	metal binding site [ion binding]; metal-binding site
290317001525	Major Facilitator Superfamily; Region: MFS_1; pfam07690
290317001526	catalytic residue [active]
290317001527	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
290317001528	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
290317001529	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
290317001530	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
290317001531	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
290317001532	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
290317001533	pyruvate phosphate dikinase; Provisional; Region: PRK09279
290317001534	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
290317001535	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
290317001536	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
290317001537	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
290317001538	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
290317001539	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
290317001540	TM-ABC transporter signature motif; other site
290317001541	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
290317001542	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
290317001543	conserved cys residue [active]
290317001544	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
290317001545	DNA binding residues [nucleotide binding]
290317001546	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; pfam09603
290317001547	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
290317001548	Isochorismatase family; Region: Isochorismatase; pfam00857
290317001549	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
290317001550	catalytic triad [active]
290317001551	dimer interface [polypeptide binding]; other site
290317001552	conserved cis-peptide bond; other site
290317001553	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
290317001554	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
290317001555	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
290317001556	putative acyl-acceptor binding pocket; other site
290317001557	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
290317001558	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
290317001559	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
290317001560	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
290317001561	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
290317001562	MPN+ (JAMM) motif; other site
290317001563	Zinc-binding site [ion binding]; other site
290317001564	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
290317001565	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
290317001566	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
290317001567	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
290317001568	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
290317001569	active site
290317001570	ribulose/triose binding site [chemical binding]; other site
290317001571	phosphate binding site [ion binding]; other site
290317001572	substrate (anthranilate) binding pocket [chemical binding]; other site
290317001573	product (indole) binding pocket [chemical binding]; other site
290317001574	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
290317001575	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
290317001576	substrate binding site [chemical binding]; other site
290317001577	hexamer interface [polypeptide binding]; other site
290317001578	metal binding site [ion binding]; metal-binding site
290317001579	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
290317001580	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
290317001581	Surface antigen; Region: Bac_surface_Ag; pfam01103
290317001582	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
290317001583	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
290317001584	Peptidase family M23; Region: Peptidase_M23; pfam01551
290317001585	DNA polymerase I; Provisional; Region: PRK05755
290317001586	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
290317001587	active site
290317001588	metal binding site 1 [ion binding]; metal-binding site
290317001589	putative 5' ssDNA interaction site; other site
290317001590	metal binding site 3; metal-binding site
290317001591	metal binding site 2 [ion binding]; metal-binding site
290317001592	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
290317001593	putative DNA binding site [nucleotide binding]; other site
290317001594	putative metal binding site [ion binding]; other site
290317001595	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
290317001596	active site
290317001597	catalytic site [active]
290317001598	substrate binding site [chemical binding]; other site
290317001599	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
290317001600	active site
290317001601	DNA binding site [nucleotide binding]
290317001602	catalytic site [active]
290317001603	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
290317001604	Prephenate dehydratase; Region: PDT; pfam00800
290317001605	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
290317001606	putative L-Phe binding site [chemical binding]; other site
290317001607	hypothetical protein; Validated; Region: PRK00110
290317001608	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
290317001609	active site
290317001610	putative DNA-binding cleft [nucleotide binding]; other site
290317001611	dimer interface [polypeptide binding]; other site
290317001612	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
290317001613	bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188
290317001614	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
290317001615	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
290317001616	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
290317001617	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
290317001618	ligand binding site [chemical binding]; other site
290317001619	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
290317001620	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
290317001621	active site
290317001622	dimerization interface [polypeptide binding]; other site
290317001623	TspO/MBR family; Region: TspO_MBR; pfam03073
290317001624	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
290317001625	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
290317001626	acyl-activating enzyme (AAE) consensus motif; other site
290317001627	AMP binding site [chemical binding]; other site
290317001628	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
290317001629	Condensation domain; Region: Condensation; pfam00668
290317001630	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
290317001631	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
290317001632	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
290317001633	acyl-activating enzyme (AAE) consensus motif; other site
290317001634	AMP binding site [chemical binding]; other site
290317001635	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
290317001636	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
290317001637	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
290317001638	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
290317001639	Coenzyme A binding pocket [chemical binding]; other site
290317001640	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
290317001641	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
290317001642	acetyl-CoA synthetase; Provisional; Region: PRK00174
290317001643	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
290317001644	active site
290317001645	CoA binding site [chemical binding]; other site
290317001646	acyl-activating enzyme (AAE) consensus motif; other site
290317001647	AMP binding site [chemical binding]; other site
290317001648	acetate binding site [chemical binding]; other site
290317001649	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
290317001650	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
290317001651	HIGH motif; other site
290317001652	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
290317001653	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
290317001654	active site
290317001655	KMSKS motif; other site
290317001656	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
290317001657	tRNA binding surface [nucleotide binding]; other site
290317001658	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
290317001659	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
290317001660	RNase E interface [polypeptide binding]; other site
290317001661	trimer interface [polypeptide binding]; other site
290317001662	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
290317001663	RNase E interface [polypeptide binding]; other site
290317001664	trimer interface [polypeptide binding]; other site
290317001665	active site
290317001666	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
290317001667	putative nucleic acid binding region [nucleotide binding]; other site
290317001668	G-X-X-G motif; other site
290317001669	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
290317001670	RNA binding site [nucleotide binding]; other site
290317001671	domain interface; other site
290317001672	Pantoate-beta-alanine ligase; Region: PanC; cd00560
290317001673	pantoate--beta-alanine ligase; Region: panC; TIGR00018
290317001674	active site
290317001675	ATP-binding site [chemical binding]; other site
290317001676	pantoate-binding site; other site
290317001677	HXXH motif; other site
290317001678	Predicted methyltransferases [General function prediction only]; Region: COG0313
290317001679	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
290317001680	putative SAM binding site [chemical binding]; other site
290317001681	putative homodimer interface [polypeptide binding]; other site
290317001682	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
290317001683	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
290317001684	Walker A/P-loop; other site
290317001685	ATP binding site [chemical binding]; other site
290317001686	Q-loop/lid; other site
290317001687	ABC transporter signature motif; other site
290317001688	Walker B; other site
290317001689	D-loop; other site
290317001690	H-loop/switch region; other site
290317001691	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
290317001692	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
290317001693	oligomer interface [polypeptide binding]; other site
290317001694	tandem repeat interface [polypeptide binding]; other site
290317001695	active site residues [active]
290317001696	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
290317001697	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
290317001698	tandem repeat interface [polypeptide binding]; other site
290317001699	oligomer interface [polypeptide binding]; other site
290317001700	active site residues [active]
290317001701	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
290317001702	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
290317001703	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317001704	Walker A motif; other site
290317001705	ATP binding site [chemical binding]; other site
290317001706	Walker B motif; other site
290317001707	arginine finger; other site
290317001708	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
290317001709	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
290317001710	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
290317001711	Photosystem P840 reaction-centre cytochrome c-551; Region: Cytochrome-c551; pfam10643
290317001712	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
290317001713	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290317001714	S-adenosylmethionine binding site [chemical binding]; other site
290317001715	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
290317001716	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
290317001717	active site
290317001718	Int/Topo IB signature motif; other site
290317001719	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
290317001720	30S subunit binding site; other site
290317001721	HPr kinase/phosphorylase; Provisional; Region: PRK05428
290317001722	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
290317001723	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
290317001724	Hpr binding site; other site
290317001725	active site
290317001726	homohexamer subunit interaction site [polypeptide binding]; other site
290317001727	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
290317001728	The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514
290317001729	peptide binding site [polypeptide binding]; other site
290317001730	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
290317001731	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
290317001732	dimer interface [polypeptide binding]; other site
290317001733	conserved gate region; other site
290317001734	putative PBP binding loops; other site
290317001735	ABC-ATPase subunit interface; other site
290317001736	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
290317001737	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317001738	Walker A motif; other site
290317001739	ATP binding site [chemical binding]; other site
290317001740	Walker B motif; other site
290317001741	arginine finger; other site
290317001742	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
290317001743	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317001744	TPR motif; other site
290317001745	binding surface
290317001746	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317001747	TPR motif; other site
290317001748	binding surface
290317001749	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
290317001750	TPR motif; other site
290317001751	binding surface
290317001752	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317001753	TPR motif; other site
290317001754	binding surface
290317001755	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290317001756	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
290317001757	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
290317001758	dimer interface [polypeptide binding]; other site
290317001759	PYR/PP interface [polypeptide binding]; other site
290317001760	TPP binding site [chemical binding]; other site
290317001761	substrate binding site [chemical binding]; other site
290317001762	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
290317001763	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
290317001764	Domain of unknown function; Region: EKR; pfam10371
290317001765	4Fe-4S binding domain; Region: Fer4_6; pfam12837
290317001766	4Fe-4S binding domain; Region: Fer4; pfam00037
290317001767	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
290317001768	TPP-binding site [chemical binding]; other site
290317001769	dimer interface [polypeptide binding]; other site
290317001770	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
290317001771	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
290317001772	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
290317001773	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
290317001774	lipoyl attachment site [posttranslational modification]; other site
290317001775	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
290317001776	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
290317001777	tetramer interface [polypeptide binding]; other site
290317001778	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290317001779	catalytic residue [active]
290317001780	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
290317001781	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
290317001782	dimer interface [polypeptide binding]; other site
290317001783	active site
290317001784	catalytic residue [active]
290317001785	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
290317001786	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
290317001787	Walker A/P-loop; other site
290317001788	ATP binding site [chemical binding]; other site
290317001789	Q-loop/lid; other site
290317001790	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
290317001791	ABC transporter signature motif; other site
290317001792	Walker B; other site
290317001793	D-loop; other site
290317001794	H-loop/switch region; other site
290317001795	twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411
290317001796	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
290317001797	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
290317001798	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
290317001799	Ligand Binding Site [chemical binding]; other site
290317001800	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
290317001801	RNA/DNA hybrid binding site [nucleotide binding]; other site
290317001802	active site
290317001803	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
290317001804	bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566
290317001805	UbiA prenyltransferase family; Region: UbiA; pfam01040
290317001806	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
290317001807	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
290317001808	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
290317001809	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
290317001810	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
290317001811	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
290317001812	active site
290317001813	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
290317001814	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
290317001815	DNA polymerase III subunit delta'; Validated; Region: PRK08485
290317001816	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
290317001817	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
290317001818	homodimer interface [polypeptide binding]; other site
290317001819	substrate-cofactor binding pocket; other site
290317001820	catalytic residue [active]
290317001821	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
290317001822	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
290317001823	active site
290317001824	ADP/pyrophosphate binding site [chemical binding]; other site
290317001825	allosteric effector site; other site
290317001826	dimerization interface [polypeptide binding]; other site
290317001827	fructose-1,6-bisphosphate binding site; other site
290317001828	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
290317001829	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
290317001830	FtsX-like permease family; Region: FtsX; pfam02687
290317001831	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
290317001832	homotrimer interaction site [polypeptide binding]; other site
290317001833	zinc binding site [ion binding]; other site
290317001834	CDP-binding sites; other site
290317001835	Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
290317001836	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
290317001837	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
290317001838	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
290317001839	heterodimer interface [polypeptide binding]; other site
290317001840	active site
290317001841	FMN binding site [chemical binding]; other site
290317001842	homodimer interface [polypeptide binding]; other site
290317001843	substrate binding site [chemical binding]; other site
290317001844	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
290317001845	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
290317001846	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
290317001847	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
290317001848	putative active site [active]
290317001849	putative metal binding site [ion binding]; other site
290317001850	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
290317001851	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
290317001852	Ferritin-like domain; Region: Ferritin; pfam00210
290317001853	ferroxidase diiron center [ion binding]; other site
290317001854	Putative molybdenum carrier; Region: MoCo_carrier; pfam12694
290317001855	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
290317001856	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096
290317001857	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
290317001858	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
290317001859	ATP-grasp domain; Region: ATP-grasp_4; cl17255
290317001860	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
290317001861	IMP binding site; other site
290317001862	dimer interface [polypeptide binding]; other site
290317001863	interdomain contacts; other site
290317001864	partial ornithine binding site; other site
290317001865	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
290317001866	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
290317001867	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
290317001868	dimerization interface [polypeptide binding]; other site
290317001869	active site
290317001870	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
290317001871	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
290317001872	dimer interface [polypeptide binding]; other site
290317001873	active site
290317001874	glycine-pyridoxal phosphate binding site [chemical binding]; other site
290317001875	folate binding site [chemical binding]; other site
290317001876	DNA primase; Validated; Region: dnaG; PRK05667
290317001877	CHC2 zinc finger; Region: zf-CHC2; pfam01807
290317001878	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
290317001879	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
290317001880	active site
290317001881	metal binding site [ion binding]; metal-binding site
290317001882	interdomain interaction site; other site
290317001883	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
290317001884	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
290317001885	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
290317001886	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
290317001887	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
290317001888	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
290317001889	Methyltransferase domain; Region: Methyltransf_23; pfam13489
290317001890	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
290317001891	S-adenosylmethionine binding site [chemical binding]; other site
290317001892	Protein of unknown function (DUF3098); Region: DUF3098; pfam11297
290317001893	acetylornithine aminotransferase; Provisional; Region: PRK02627
290317001894	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
290317001895	inhibitor-cofactor binding pocket; inhibition site
290317001896	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290317001897	catalytic residue [active]
290317001898	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
290317001899	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
290317001900	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
290317001901	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
290317001902	AIR carboxylase; Region: AIRC; pfam00731
290317001903	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
290317001904	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290317001905	FeS/SAM binding site; other site
290317001906	HemN C-terminal domain; Region: HemN_C; pfam06969
290317001907	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
290317001908	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
290317001909	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
290317001910	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
290317001911	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290317001912	PAS fold; Region: PAS_3; pfam08447
290317001913	putative active site [active]
290317001914	heme pocket [chemical binding]; other site
290317001915	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
290317001916	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
290317001917	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290317001918	dimer interface [polypeptide binding]; other site
290317001919	phosphorylation site [posttranslational modification]
290317001920	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290317001921	ATP binding site [chemical binding]; other site
290317001922	Mg2+ binding site [ion binding]; other site
290317001923	G-X-G motif; other site
290317001924	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
290317001925	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290317001926	active site
290317001927	phosphorylation site [posttranslational modification]
290317001928	intermolecular recognition site; other site
290317001929	dimerization interface [polypeptide binding]; other site
290317001930	Response regulator receiver domain; Region: Response_reg; pfam00072
290317001931	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290317001932	active site
290317001933	phosphorylation site [posttranslational modification]
290317001934	intermolecular recognition site; other site
290317001935	dimerization interface [polypeptide binding]; other site
290317001936	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
290317001937	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290317001938	Walker A/P-loop; other site
290317001939	ATP binding site [chemical binding]; other site
290317001940	Q-loop/lid; other site
290317001941	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
290317001942	ABC transporter; Region: ABC_tran_2; pfam12848
290317001943	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
290317001944	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
290317001945	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
290317001946	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
290317001947	HlyD family secretion protein; Region: HlyD_3; pfam13437
290317001948	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
290317001949	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
290317001950	Walker A/P-loop; other site
290317001951	ATP binding site [chemical binding]; other site
290317001952	Q-loop/lid; other site
290317001953	ABC transporter signature motif; other site
290317001954	Walker B; other site
290317001955	D-loop; other site
290317001956	H-loop/switch region; other site
290317001957	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
290317001958	FtsX-like permease family; Region: FtsX; pfam02687
290317001959	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
290317001960	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
290317001961	CoA-ligase; Region: Ligase_CoA; pfam00549
290317001962	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
290317001963	nucleoside/Zn binding site; other site
290317001964	dimer interface [polypeptide binding]; other site
290317001965	catalytic motif [active]
290317001966	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
290317001967	FMN binding site [chemical binding]; other site
290317001968	substrate binding site [chemical binding]; other site
290317001969	putative catalytic residue [active]
290317001970	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
290317001971	catalytic core [active]
290317001972	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
290317001973	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
290317001974	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
290317001975	active site
290317001976	dimer interface [polypeptide binding]; other site
290317001977	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
290317001978	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
290317001979	active site
290317001980	FMN binding site [chemical binding]; other site
290317001981	substrate binding site [chemical binding]; other site
290317001982	3Fe-4S cluster binding site [ion binding]; other site
290317001983	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
290317001984	domain interface; other site
290317001985	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
290317001986	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
290317001987	Domain of unknown function (DUF4404); Region: DUF4404; pfam14357
290317001988	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
290317001989	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
290317001990	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317001991	Walker A motif; other site
290317001992	ATP binding site [chemical binding]; other site
290317001993	Walker B motif; other site
290317001994	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
290317001995	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290317001996	ATP binding site [chemical binding]; other site
290317001997	putative Mg++ binding site [ion binding]; other site
290317001998	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
290317001999	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
290317002000	nucleotide binding region [chemical binding]; other site
290317002001	ATP-binding site [chemical binding]; other site
290317002002	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
290317002003	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
290317002004	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
290317002005	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
290317002006	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
290317002007	Protein of unknown function (DUF1156); Region: DUF1156; pfam06634
290317002008	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
290317002009	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483
290317002010	Protein of unknown function (DUF499); Region: DUF499; pfam04465
290317002011	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
290317002012	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
290317002013	Fic family protein [Function unknown]; Region: COG3177
290317002014	Fic/DOC family; Region: Fic; pfam02661
290317002015	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
290317002016	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
290317002017	Integrase core domain; Region: rve; pfam00665
290317002018	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
290317002019	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317002020	Walker A motif; other site
290317002021	ATP binding site [chemical binding]; other site
290317002022	Walker B motif; other site
290317002023	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
290317002024	AAA ATPase domain; Region: AAA_16; pfam13191
290317002025	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
290317002026	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
290317002027	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
290317002028	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
290317002029	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
290317002030	non-specific DNA binding site [nucleotide binding]; other site
290317002031	salt bridge; other site
290317002032	sequence-specific DNA binding site [nucleotide binding]; other site
290317002033	Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404
290317002034	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
290317002035	putative active site [active]
290317002036	putative metal binding site [ion binding]; other site
290317002037	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
290317002038	Transposase; Region: DDE_Tnp_ISL3; pfam01610
290317002039	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
290317002040	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
290317002041	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
290317002042	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
290317002043	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
290317002044	purine monophosphate binding site [chemical binding]; other site
290317002045	dimer interface [polypeptide binding]; other site
290317002046	putative catalytic residues [active]
290317002047	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
290317002048	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
290317002049	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
290317002050	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
290317002051	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
290317002052	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
290317002053	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
290317002054	iron-sulfur cluster [ion binding]; other site
290317002055	[2Fe-2S] cluster binding site [ion binding]; other site
290317002056	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
290317002057	Beta-lactamase; Region: Beta-lactamase; pfam00144
290317002058	mce related protein; Region: MCE; pfam02470
290317002059	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
290317002060	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
290317002061	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
290317002062	Walker A/P-loop; other site
290317002063	ATP binding site [chemical binding]; other site
290317002064	Q-loop/lid; other site
290317002065	ABC transporter signature motif; other site
290317002066	Walker B; other site
290317002067	D-loop; other site
290317002068	H-loop/switch region; other site
290317002069	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
290317002070	Permease; Region: Permease; pfam02405
290317002071	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
290317002072	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
290317002073	active site
290317002074	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
290317002075	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
290317002076	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
290317002077	active site
290317002078	dimerization interface [polypeptide binding]; other site
290317002079	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
290317002080	active site
290317002081	hydrophilic channel; other site
290317002082	dimerization interface [polypeptide binding]; other site
290317002083	catalytic residues [active]
290317002084	active site lid [active]
290317002085	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
290317002086	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
290317002087	Walker A/P-loop; other site
290317002088	ATP binding site [chemical binding]; other site
290317002089	Q-loop/lid; other site
290317002090	ABC transporter signature motif; other site
290317002091	Walker B; other site
290317002092	D-loop; other site
290317002093	H-loop/switch region; other site
290317002094	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
290317002095	Smr domain; Region: Smr; pfam01713
290317002096	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
290317002097	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
290317002098	tetramer interfaces [polypeptide binding]; other site
290317002099	binuclear metal-binding site [ion binding]; other site
290317002100	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
290317002101	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
290317002102	TPP-binding site; other site
290317002103	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
290317002104	PYR/PP interface [polypeptide binding]; other site
290317002105	dimer interface [polypeptide binding]; other site
290317002106	TPP binding site [chemical binding]; other site
290317002107	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
290317002108	Uncharacterized conserved protein [Function unknown]; Region: COG0432
290317002109	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347
290317002110	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
290317002111	active site
290317002112	catalytic site [active]
290317002113	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
290317002114	Part of AAA domain; Region: AAA_19; pfam13245
290317002115	Family description; Region: UvrD_C_2; pfam13538
290317002116	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
290317002117	Flavoprotein; Region: Flavoprotein; cl08021
290317002118	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
290317002119	FMN binding site [chemical binding]; other site
290317002120	dimer interface [polypeptide binding]; other site
290317002121	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
290317002122	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
290317002123	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
290317002124	P loop; other site
290317002125	Nucleotide binding site [chemical binding]; other site
290317002126	DTAP/Switch II; other site
290317002127	Switch I; other site
290317002128	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
290317002129	Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561
290317002130	NAD binding site [chemical binding]; other site
290317002131	homotetramer interface [polypeptide binding]; other site
290317002132	homodimer interface [polypeptide binding]; other site
290317002133	substrate binding site [chemical binding]; other site
290317002134	active site
290317002135	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
290317002136	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
290317002137	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
290317002138	Pirin-related protein [General function prediction only]; Region: COG1741
290317002139	Pirin; Region: Pirin; pfam02678
290317002140	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
290317002141	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
290317002142	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
290317002143	putative active site [active]
290317002144	metal binding site [ion binding]; metal-binding site
290317002145	homodimer binding site [polypeptide binding]; other site
290317002146	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
290317002147	AMP binding site [chemical binding]; other site
290317002148	metal binding site [ion binding]; metal-binding site
290317002149	active site
290317002150	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
290317002151	DHH family; Region: DHH; pfam01368
290317002152	DHHA1 domain; Region: DHHA1; pfam02272
290317002153	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
290317002154	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
290317002155	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
290317002156	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
290317002157	Ligand binding site; other site
290317002158	Putative Catalytic site; other site
290317002159	DXD motif; other site
290317002160	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
290317002161	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
290317002162	PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389
290317002163	active site
290317002164	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
290317002165	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
290317002166	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
290317002167	putative active site [active]
290317002168	putative substrate binding site [chemical binding]; other site
290317002169	putative cosubstrate binding site; other site
290317002170	catalytic site [active]
290317002171	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
290317002172	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
290317002173	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
290317002174	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
290317002175	coenzyme F420 hydrogenase, subunit beta; Region: frhB; TIGR03289
290317002176	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
290317002177	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
290317002178	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
290317002179	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290317002180	Walker A/P-loop; other site
290317002181	ATP binding site [chemical binding]; other site
290317002182	Q-loop/lid; other site
290317002183	ABC transporter signature motif; other site
290317002184	Walker B; other site
290317002185	D-loop; other site
290317002186	H-loop/switch region; other site
290317002187	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
290317002188	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
290317002189	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290317002190	Walker A/P-loop; other site
290317002191	ATP binding site [chemical binding]; other site
290317002192	Q-loop/lid; other site
290317002193	ABC transporter signature motif; other site
290317002194	Walker B; other site
290317002195	D-loop; other site
290317002196	H-loop/switch region; other site
290317002197	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
290317002198	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
290317002199	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
290317002200	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
290317002201	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
290317002202	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
290317002203	purine nucleoside phosphorylase; Provisional; Region: PRK08202
290317002204	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
290317002205	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
290317002206	catalytic residue [active]
290317002207	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
290317002208	active site
290317002209	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
290317002210	active site
290317002211	lipoprotein signal peptidase; Provisional; Region: PRK14787
290317002212	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
290317002213	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
290317002214	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
290317002215	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
290317002216	shikimate binding site; other site
290317002217	NAD(P) binding site [chemical binding]; other site
290317002218	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317002219	binding surface
290317002220	TPR motif; other site
290317002221	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317002222	binding surface
290317002223	TPR motif; other site
290317002224	TPR repeat; Region: TPR_11; pfam13414
290317002225	TPR repeat; Region: TPR_11; pfam13414
290317002226	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317002227	binding surface
290317002228	TPR motif; other site
290317002229	TPR repeat; Region: TPR_11; pfam13414
290317002230	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317002231	binding surface
290317002232	TPR motif; other site
290317002233	TPR repeat; Region: TPR_11; pfam13414
290317002234	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317002235	binding surface
290317002236	TPR motif; other site
290317002237	TPR repeat; Region: TPR_11; pfam13414
290317002238	excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14671
290317002239	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
290317002240	GIY-YIG motif/motif A; other site
290317002241	active site
290317002242	catalytic site [active]
290317002243	putative DNA binding site [nucleotide binding]; other site
290317002244	metal binding site [ion binding]; metal-binding site
290317002245	UvrB/uvrC motif; Region: UVR; pfam02151
290317002246	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
290317002247	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
290317002248	DNA binding site [nucleotide binding]
290317002249	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290317002250	putative substrate translocation pore; other site
290317002251	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
290317002252	Ligand Binding Site [chemical binding]; other site
290317002253	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
290317002254	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
290317002255	Transposase; Region: DDE_Tnp_ISL3; pfam01610
290317002256	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
290317002257	nudix motif; other site
290317002258	Protein of unknown function (DUF1207); Region: DUF1207; pfam06727
290317002259	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
290317002260	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
290317002261	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
290317002262	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
290317002263	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
290317002264	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
290317002265	Acylphosphatase; Region: Acylphosphatase; pfam00708
290317002266	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
290317002267	HypF finger; Region: zf-HYPF; pfam07503
290317002268	HypF finger; Region: zf-HYPF; pfam07503
290317002269	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
290317002270	HupF/HypC family; Region: HupF_HypC; pfam01455
290317002271	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
290317002272	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
290317002273	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
290317002274	dimerization interface [polypeptide binding]; other site
290317002275	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
290317002276	ATP binding site [chemical binding]; other site
290317002277	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
290317002278	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
290317002279	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
290317002280	ATP binding site [chemical binding]; other site
290317002281	substrate interface [chemical binding]; other site
290317002282	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290317002283	Radical SAM superfamily; Region: Radical_SAM; pfam04055
290317002284	FeS/SAM binding site; other site
290317002285	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
290317002286	thiazole synthase; Reviewed; Region: thiG; PRK00208
290317002287	phosphate binding site [ion binding]; other site
290317002288	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
290317002289	thiS-thiF/thiG interaction site; other site
290317002290	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
290317002291	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
290317002292	homodimer interface [polypeptide binding]; other site
290317002293	substrate-cofactor binding pocket; other site
290317002294	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290317002295	catalytic residue [active]
290317002296	MOSC domain; Region: MOSC; pfam03473
290317002297	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
290317002298	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290317002299	FeS/SAM binding site; other site
290317002300	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
290317002301	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
290317002302	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
290317002303	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
290317002304	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
290317002305	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
290317002306	dimer interface [polypeptide binding]; other site
290317002307	[2Fe-2S] cluster binding site [ion binding]; other site
290317002308	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
290317002309	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290317002310	FeS/SAM binding site; other site
290317002311	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
290317002312	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
290317002313	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
290317002314	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
290317002315	MoFe protein beta/alpha subunit interactions; other site
290317002316	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
290317002317	Beta subunit P cluster binding residues; other site
290317002318	MoFe protein beta subunit/Fe protein contacts; other site
290317002319	MoFe protein dimer/ dimer interactions; other site
290317002320	nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284
290317002321	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
290317002322	MoFe protein alpha/beta subunit interactions; other site
290317002323	Alpha subunit P cluster binding residues; other site
290317002324	FeMoco binding residues [chemical binding]; other site
290317002325	MoFe protein alpha subunit/Fe protein contacts; other site
290317002326	MoFe protein dimer/ dimer interactions; other site
290317002327	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
290317002328	Nitrogen regulatory protein P-II; Region: P-II; smart00938
290317002329	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
290317002330	Nitrogen regulatory protein P-II; Region: P-II; smart00938
290317002331	nitrogenase reductase; Reviewed; Region: nifH; PRK13235
290317002332	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
290317002333	Nucleotide-binding sites [chemical binding]; other site
290317002334	Walker A motif; other site
290317002335	Switch I region of nucleotide binding site; other site
290317002336	Fe4S4 binding sites [ion binding]; other site
290317002337	Switch II region of nucleotide binding site; other site
290317002338	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
290317002339	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
290317002340	Cation efflux family; Region: Cation_efflux; cl00316
290317002341	Cation efflux family; Region: Cation_efflux; cl00316
290317002342	S-adenosylmethionine synthetase (AdoMet synthetase); Region: AdoMet_Synthase; pfam01941
290317002343	MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937
290317002344	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
290317002345	Cation efflux family; Region: Cation_efflux; pfam01545
290317002346	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
290317002347	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
290317002348	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
290317002349	metal binding site 2 [ion binding]; metal-binding site
290317002350	putative DNA binding helix; other site
290317002351	metal binding site 1 [ion binding]; metal-binding site
290317002352	dimer interface [polypeptide binding]; other site
290317002353	structural Zn2+ binding site [ion binding]; other site
290317002354	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
290317002355	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
290317002356	dimer interface [polypeptide binding]; other site
290317002357	active site
290317002358	heme binding site [chemical binding]; other site
290317002359	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
290317002360	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
290317002361	PHP domain; Region: PHP; pfam02811
290317002362	active site
290317002363	Predicted permease; Region: DUF318; cl17795
290317002364	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
290317002365	dimerization interface [polypeptide binding]; other site
290317002366	putative DNA binding site [nucleotide binding]; other site
290317002367	putative Zn2+ binding site [ion binding]; other site
290317002368	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
290317002369	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
290317002370	short chain dehydrogenase; Provisional; Region: PRK07832
290317002371	classical (c) SDRs; Region: SDR_c; cd05233
290317002372	NAD(P) binding site [chemical binding]; other site
290317002373	active site
290317002374	Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314
290317002375	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
290317002376	classical (c) SDRs; Region: SDR_c; cd05233
290317002377	NAD(P) binding site [chemical binding]; other site
290317002378	active site
290317002379	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
290317002380	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
290317002381	active site
290317002382	FMN binding site [chemical binding]; other site
290317002383	substrate binding site [chemical binding]; other site
290317002384	putative catalytic residue [active]
290317002385	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
290317002386	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
290317002387	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
290317002388	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
290317002389	active site
290317002390	NTP binding site [chemical binding]; other site
290317002391	metal binding triad [ion binding]; metal-binding site
290317002392	antibiotic binding site [chemical binding]; other site
290317002393	Protein of unknown function DUF86; Region: DUF86; pfam01934
290317002394	Protein of unknown function DUF86; Region: DUF86; pfam01934
290317002395	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
290317002396	Protein of unknown function (DUF3018); Region: DUF3018; pfam11455
290317002397	AAA domain; Region: AAA_14; pfam13173
290317002398	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
290317002399	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
290317002400	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
290317002401	Protein export membrane protein; Region: SecD_SecF; cl14618
290317002402	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
290317002403	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
290317002404	HlyD family secretion protein; Region: HlyD_3; pfam13437
290317002405	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
290317002406	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
290317002407	AAA domain; Region: AAA_14; pfam13173
290317002408	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
290317002409	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
290317002410	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
290317002411	Walker A motif; other site
290317002412	ATP binding site [chemical binding]; other site
290317002413	Walker B motif; other site
290317002414	arginine finger; other site
290317002415	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
290317002416	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
290317002417	AAA domain; Region: AAA_14; pfam13173
290317002418	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
290317002419	Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459
290317002420	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
290317002421	non-specific DNA binding site [nucleotide binding]; other site
290317002422	salt bridge; other site
290317002423	sequence-specific DNA binding site [nucleotide binding]; other site
290317002424	CHAT domain; Region: CHAT; pfam12770
290317002425	AAA ATPase domain; Region: AAA_16; pfam13191
290317002426	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
290317002427	Walker A motif; other site
290317002428	ATP binding site [chemical binding]; other site
290317002429	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290317002430	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317002431	binding surface
290317002432	TPR motif; other site
290317002433	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290317002434	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317002435	binding surface
290317002436	TPR motif; other site
290317002437	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290317002438	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317002439	binding surface
290317002440	TPR motif; other site
290317002441	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290317002442	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290317002443	CpXC protein; Region: CpXC; pfam14353
290317002444	CHAT domain; Region: CHAT; pfam12770
290317002445	AAA ATPase domain; Region: AAA_16; pfam13191
290317002446	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290317002447	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317002448	TPR motif; other site
290317002449	binding surface
290317002450	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290317002451	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290317002452	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317002453	binding surface
290317002454	TPR motif; other site
290317002455	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290317002456	CheB methylesterase; Region: CheB_methylest; pfam01339
290317002457	CsbD-like; Region: CsbD; cl17424
290317002458	Predicted flavoprotein [General function prediction only]; Region: COG0431
290317002459	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
290317002460	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290317002461	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
290317002462	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
290317002463	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
290317002464	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
290317002465	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
290317002466	rod shape-determining protein MreB; Provisional; Region: PRK13930
290317002467	MreB and similar proteins; Region: MreB_like; cd10225
290317002468	nucleotide binding site [chemical binding]; other site
290317002469	Mg binding site [ion binding]; other site
290317002470	putative protofilament interaction site [polypeptide binding]; other site
290317002471	RodZ interaction site [polypeptide binding]; other site
290317002472	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
290317002473	histidinol dehydrogenase; Region: hisD; TIGR00069
290317002474	NAD binding site [chemical binding]; other site
290317002475	dimerization interface [polypeptide binding]; other site
290317002476	product binding site; other site
290317002477	substrate binding site [chemical binding]; other site
290317002478	zinc binding site [ion binding]; other site
290317002479	catalytic residues [active]
290317002480	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
290317002481	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
290317002482	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
290317002483	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
290317002484	substrate binding site [chemical binding]; other site
290317002485	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
290317002486	substrate binding site [chemical binding]; other site
290317002487	ligand binding site [chemical binding]; other site
290317002488	Membrane transport protein; Region: Mem_trans; cl09117
290317002489	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
290317002490	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
290317002491	hinge; other site
290317002492	active site
290317002493	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
290317002494	Peptidase family M23; Region: Peptidase_M23; pfam01551
290317002495	NAD synthetase; Provisional; Region: PRK13980
290317002496	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
290317002497	homodimer interface [polypeptide binding]; other site
290317002498	NAD binding pocket [chemical binding]; other site
290317002499	ATP binding pocket [chemical binding]; other site
290317002500	Mg binding site [ion binding]; other site
290317002501	active-site loop [active]
290317002502	L-aspartate oxidase; Provisional; Region: PRK09077
290317002503	L-aspartate oxidase; Provisional; Region: PRK06175
290317002504	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
290317002505	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
290317002506	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
290317002507	pyruvoyl-dependent arginine decarboxylase; Reviewed; Region: PRK01285
290317002508	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
290317002509	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
290317002510	active site
290317002511	HIGH motif; other site
290317002512	dimer interface [polypeptide binding]; other site
290317002513	KMSKS motif; other site
290317002514	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
290317002515	RNA binding surface [nucleotide binding]; other site
290317002516	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
290317002517	SmpB-tmRNA interface; other site
290317002518	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
290317002519	FAD binding domain; Region: FAD_binding_4; pfam01565
290317002520	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
290317002521	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
290317002522	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
290317002523	rod shape-determining protein MreC; Provisional; Region: PRK13922
290317002524	rod shape-determining protein MreC; Region: MreC; pfam04085
290317002525	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
290317002526	oligomerisation interface [polypeptide binding]; other site
290317002527	mobile loop; other site
290317002528	roof hairpin; other site
290317002529	quinolinate synthetase; Provisional; Region: PRK09375
290317002530	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
290317002531	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
290317002532	bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001
290317002533	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
290317002534	trimer interface [polypeptide binding]; other site
290317002535	active site
290317002536	chlorosome envelope protein H repeat; Region: rpt_csmH; TIGR03058
290317002537	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
290317002538	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
290317002539	Probable Catalytic site; other site
290317002540	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
290317002541	radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167
290317002542	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290317002543	FeS/SAM binding site; other site
290317002544	Protein of unknown function (DUF3641); Region: DUF3641; pfam12345
290317002545	phytoene desaturase; Region: phytoene_desat; TIGR02731
290317002546	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
290317002547	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
290317002548	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
290317002549	dimerization interface [polypeptide binding]; other site
290317002550	putative DNA binding site [nucleotide binding]; other site
290317002551	putative Zn2+ binding site [ion binding]; other site
290317002552	AsnC family; Region: AsnC_trans_reg; pfam01037
290317002553	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
290317002554	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
290317002555	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
290317002556	Uncharacterized conserved protein [Function unknown]; Region: COG0432
290317002557	pantothenate kinase; Reviewed; Region: PRK13320
290317002558	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
290317002559	active site
290317002560	dimer interface [polypeptide binding]; other site
290317002561	metal binding site [ion binding]; metal-binding site
290317002562	shikimate kinase; Reviewed; Region: aroK; PRK00131
290317002563	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
290317002564	ADP binding site [chemical binding]; other site
290317002565	magnesium binding site [ion binding]; other site
290317002566	putative shikimate binding site; other site
290317002567	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
290317002568	AAA domain; Region: AAA_30; pfam13604
290317002569	Family description; Region: UvrD_C_2; pfam13538
290317002570	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
290317002571	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
290317002572	catalytic triad [active]
290317002573	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672
290317002574	AAA ATPase domain; Region: AAA_16; pfam13191
290317002575	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
290317002576	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
290317002577	FOG: WD40 repeat [General function prediction only]; Region: COG2319
290317002578	structural tetrad; other site
290317002579	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
290317002580	FOG: WD40 repeat [General function prediction only]; Region: COG2319
290317002581	structural tetrad; other site
290317002582	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
290317002583	structural tetrad; other site
290317002584	WD40 repeats; Region: WD40; smart00320
290317002585	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
290317002586	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
290317002587	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
290317002588	Walker A/P-loop; other site
290317002589	ATP binding site [chemical binding]; other site
290317002590	Q-loop/lid; other site
290317002591	ABC transporter signature motif; other site
290317002592	Walker B; other site
290317002593	D-loop; other site
290317002594	H-loop/switch region; other site
290317002595	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
290317002596	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
290317002597	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290317002598	Walker A/P-loop; other site
290317002599	ATP binding site [chemical binding]; other site
290317002600	Q-loop/lid; other site
290317002601	ABC transporter signature motif; other site
290317002602	Walker B; other site
290317002603	D-loop; other site
290317002604	H-loop/switch region; other site
290317002605	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
290317002606	Uncharacterized conserved protein [Function unknown]; Region: COG1434
290317002607	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
290317002608	putative active site [active]
290317002609	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
290317002610	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
290317002611	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
290317002612	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
290317002613	active site
290317002614	catalytic residues [active]
290317002615	metal binding site [ion binding]; metal-binding site
290317002616	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
290317002617	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
290317002618	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
290317002619	substrate binding site [chemical binding]; other site
290317002620	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
290317002621	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
290317002622	substrate binding site [chemical binding]; other site
290317002623	ligand binding site [chemical binding]; other site
290317002624	2-isopropylmalate synthase; Validated; Region: PRK00915
290317002625	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
290317002626	active site
290317002627	catalytic residues [active]
290317002628	metal binding site [ion binding]; metal-binding site
290317002629	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
290317002630	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
290317002631	tartrate dehydrogenase; Region: TTC; TIGR02089
290317002632	ketol-acid reductoisomerase; Provisional; Region: PRK05479
290317002633	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
290317002634	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
290317002635	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
290317002636	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
290317002637	putative valine binding site [chemical binding]; other site
290317002638	dimer interface [polypeptide binding]; other site
290317002639	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
290317002640	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
290317002641	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
290317002642	PYR/PP interface [polypeptide binding]; other site
290317002643	dimer interface [polypeptide binding]; other site
290317002644	TPP binding site [chemical binding]; other site
290317002645	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
290317002646	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
290317002647	TPP-binding site [chemical binding]; other site
290317002648	dimer interface [polypeptide binding]; other site
290317002649	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
290317002650	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
290317002651	Integral membrane protein DUF92; Region: DUF92; pfam01940
290317002652	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
290317002653	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
290317002654	TolR protein; Region: tolR; TIGR02801
290317002655	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
290317002656	TonB C terminal; Region: TonB_2; pfam13103
290317002657	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
290317002658	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
290317002659	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
290317002660	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
290317002661	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
290317002662	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
290317002663	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
290317002664	ligand binding site [chemical binding]; other site
290317002665	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
290317002666	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
290317002667	ligand binding site [chemical binding]; other site
290317002668	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
290317002669	Tetratricopeptide repeat; Region: TPR_6; pfam13174
290317002670	Photosystem P840 reaction centre protein PscD; Region: RC-P840_PscD; pfam10657
290317002671	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
290317002672	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
290317002673	nucleotide binding site [chemical binding]; other site
290317002674	NEF interaction site [polypeptide binding]; other site
290317002675	SBD interface [polypeptide binding]; other site
290317002676	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
290317002677	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
290317002678	putative dimer interface [polypeptide binding]; other site
290317002679	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
290317002680	dimerization interface [polypeptide binding]; other site
290317002681	putative DNA binding site [nucleotide binding]; other site
290317002682	putative Zn2+ binding site [ion binding]; other site
290317002683	Putative zinc-finger; Region: zf-HC2; pfam13490
290317002684	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
290317002685	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
290317002686	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
290317002687	DNA binding residues [nucleotide binding]
290317002688	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
290317002689	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
290317002690	Transposase; Region: DDE_Tnp_ISL3; pfam01610
290317002691	carotene isomerase; Region: carot_isom; TIGR02730
290317002692	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
290317002693	RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678
290317002694	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
290317002695	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
290317002696	hexamer interface [polypeptide binding]; other site
290317002697	ligand binding site [chemical binding]; other site
290317002698	putative active site [active]
290317002699	NAD(P) binding site [chemical binding]; other site
290317002700	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
290317002701	catalytic loop [active]
290317002702	iron binding site [ion binding]; other site
290317002703	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
290317002704	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
290317002705	catalytic loop [active]
290317002706	iron binding site [ion binding]; other site
290317002707	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
290317002708	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
290317002709	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290317002710	ATP binding site [chemical binding]; other site
290317002711	putative Mg++ binding site [ion binding]; other site
290317002712	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
290317002713	nucleotide binding region [chemical binding]; other site
290317002714	ATP-binding site [chemical binding]; other site
290317002715	TRCF domain; Region: TRCF; pfam03461
290317002716	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
290317002717	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
290317002718	Walker A/P-loop; other site
290317002719	ATP binding site [chemical binding]; other site
290317002720	Q-loop/lid; other site
290317002721	ABC transporter signature motif; other site
290317002722	Walker B; other site
290317002723	D-loop; other site
290317002724	H-loop/switch region; other site
290317002725	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
290317002726	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
290317002727	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290317002728	active site
290317002729	phosphorylation site [posttranslational modification]
290317002730	intermolecular recognition site; other site
290317002731	dimerization interface [polypeptide binding]; other site
290317002732	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
290317002733	DNA binding site [nucleotide binding]
290317002734	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
290317002735	dimerization interface [polypeptide binding]; other site
290317002736	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
290317002737	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290317002738	putative active site [active]
290317002739	heme pocket [chemical binding]; other site
290317002740	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290317002741	dimer interface [polypeptide binding]; other site
290317002742	phosphorylation site [posttranslational modification]
290317002743	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290317002744	ATP binding site [chemical binding]; other site
290317002745	Mg2+ binding site [ion binding]; other site
290317002746	G-X-G motif; other site
290317002747	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
290317002748	Mechanosensitive ion channel; Region: MS_channel; pfam00924
290317002749	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
290317002750	nudix motif; other site
290317002751	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
290317002752	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
290317002753	catalytic triad [active]
290317002754	Uncharacterized ACR, COG1678; Region: DUF179; pfam02622
290317002755	LabA_like proteins; Region: LabA_like; cd06167
290317002756	putative metal binding site [ion binding]; other site
290317002757	LabA_like proteins; Region: LabA_like; cd06167
290317002758	putative metal binding site [ion binding]; other site
290317002759	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
290317002760	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
290317002761	Haemolytic domain; Region: Haemolytic; cl00506
290317002762	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
290317002763	Protein of unknown function (DUF3037); Region: DUF3037; pfam11236
290317002764	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
290317002765	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
290317002766	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
290317002767	TIR domain; Region: TIR_2; pfam13676
290317002768	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
290317002769	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290317002770	S-adenosylmethionine binding site [chemical binding]; other site
290317002771	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
290317002772	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
290317002773	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
290317002774	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
290317002775	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
290317002776	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290317002777	ATP binding site [chemical binding]; other site
290317002778	putative Mg++ binding site [ion binding]; other site
290317002779	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317002780	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
290317002781	Walker A motif; other site
290317002782	ATP binding site [chemical binding]; other site
290317002783	Walker B motif; other site
290317002784	arginine finger; other site
290317002785	Uncharacterized conserved protein [Function unknown]; Region: COG1262
290317002786	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
290317002787	TIR domain; Region: TIR_2; pfam13676
290317002788	Uncharacterized conserved protein [Function unknown]; Region: COG1262
290317002789	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
290317002790	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
290317002791	Protein of unknown function DUF45; Region: DUF45; pfam01863
290317002792	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
290317002793	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
290317002794	hexamer interface [polypeptide binding]; other site
290317002795	ligand binding site [chemical binding]; other site
290317002796	putative active site [active]
290317002797	NAD(P) binding site [chemical binding]; other site
290317002798	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
290317002799	trimer interface [polypeptide binding]; other site
290317002800	putative Zn binding site [ion binding]; other site
290317002801	TspO/MBR family; Region: TspO_MBR; pfam03073
290317002802	Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033
290317002803	putative catalytic residues [active]
290317002804	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
290317002805	putative transporter; Provisional; Region: PRK11660
290317002806	Sulfate transporter family; Region: Sulfate_transp; pfam00916
290317002807	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
290317002808	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
290317002809	Rubrerythrin [Energy production and conversion]; Region: COG1592
290317002810	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
290317002811	binuclear metal center [ion binding]; other site
290317002812	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
290317002813	iron binding site [ion binding]; other site
290317002814	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
290317002815	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
290317002816	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
290317002817	TrkA-N domain; Region: TrkA_N; pfam02254
290317002818	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
290317002819	Low molecular weight phosphatase family; Region: LMWPc; cd00115
290317002820	active site
290317002821	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
290317002822	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
290317002823	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
290317002824	active site
290317002825	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
290317002826	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
290317002827	homotetramer interface [polypeptide binding]; other site
290317002828	ligand binding site [chemical binding]; other site
290317002829	catalytic site [active]
290317002830	NAD binding site [chemical binding]; other site
290317002831	S-adenosylmethionine synthetase; Validated; Region: PRK05250
290317002832	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
290317002833	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
290317002834	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
290317002835	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
290317002836	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
290317002837	active site
290317002838	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
290317002839	putative trimer interface [polypeptide binding]; other site
290317002840	putative CoA binding site [chemical binding]; other site
290317002841	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
290317002842	nudix motif; other site
290317002843	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
290317002844	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
290317002845	putative tRNA-binding site [nucleotide binding]; other site
290317002846	B3/4 domain; Region: B3_4; pfam03483
290317002847	tRNA synthetase B5 domain; Region: B5; smart00874
290317002848	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
290317002849	dimer interface [polypeptide binding]; other site
290317002850	motif 1; other site
290317002851	motif 3; other site
290317002852	motif 2; other site
290317002853	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
290317002854	Cell division protein ZapA; Region: ZapA; pfam05164
290317002855	phosphodiesterase; Provisional; Region: PRK12704
290317002856	KH domain; Region: KH_1; pfam00013
290317002857	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
290317002858	Zn2+ binding site [ion binding]; other site
290317002859	Mg2+ binding site [ion binding]; other site
290317002860	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
290317002861	putative active site pocket [active]
290317002862	4-fold oligomerization interface [polypeptide binding]; other site
290317002863	metal binding residues [ion binding]; metal-binding site
290317002864	3-fold/trimer interface [polypeptide binding]; other site
290317002865	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
290317002866	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
290317002867	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
290317002868	Autotransporter beta-domain; Region: Autotransporter; smart00869
290317002869	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
290317002870	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
290317002871	Transposase; Region: DDE_Tnp_ISL3; pfam01610
290317002872	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
290317002873	non-specific DNA binding site [nucleotide binding]; other site
290317002874	salt bridge; other site
290317002875	sequence-specific DNA binding site [nucleotide binding]; other site
290317002876	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
290317002877	DNA methylase; Region: N6_N4_Mtase; pfam01555
290317002878	Predicted permeases [General function prediction only]; Region: COG0795
290317002879	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
290317002880	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
290317002881	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
290317002882	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
290317002883	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
290317002884	Domain of unknown function (DUF814); Region: DUF814; pfam05670
290317002885	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
290317002886	catalytic motif [active]
290317002887	Zn binding site [ion binding]; other site
290317002888	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
290317002889	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
290317002890	catalytic motif [active]
290317002891	Zn binding site [ion binding]; other site
290317002892	RibD C-terminal domain; Region: RibD_C; cl17279
290317002893	Predicted membrane protein [Function unknown]; Region: COG2259
290317002894	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
290317002895	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290317002896	Walker A/P-loop; other site
290317002897	ATP binding site [chemical binding]; other site
290317002898	Q-loop/lid; other site
290317002899	ABC transporter signature motif; other site
290317002900	Walker B; other site
290317002901	D-loop; other site
290317002902	H-loop/switch region; other site
290317002903	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
290317002904	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290317002905	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
290317002906	active site
290317002907	metal binding site [ion binding]; metal-binding site
290317002908	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
290317002909	dimer interface [polypeptide binding]; other site
290317002910	catalytic triad [active]
290317002911	peroxidatic and resolving cysteines [active]
290317002912	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_5; cd11352
290317002913	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
290317002914	active site
290317002915	catalytic site [active]
290317002916	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
290317002917	Lumazine binding domain; Region: Lum_binding; pfam00677
290317002918	Lumazine binding domain; Region: Lum_binding; pfam00677
290317002919	recombination factor protein RarA; Reviewed; Region: PRK13342
290317002920	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317002921	Walker A motif; other site
290317002922	ATP binding site [chemical binding]; other site
290317002923	Walker B motif; other site
290317002924	arginine finger; other site
290317002925	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
290317002926	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
290317002927	Methyltransferase domain; Region: Methyltransf_23; pfam13489
290317002928	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290317002929	S-adenosylmethionine binding site [chemical binding]; other site
290317002930	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
290317002931	nucleotide binding site/active site [active]
290317002932	HIT family signature motif; other site
290317002933	catalytic residue [active]
290317002934	Ferrochelatase; Region: Ferrochelatase; pfam00762
290317002935	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
290317002936	C-terminal domain interface [polypeptide binding]; other site
290317002937	active site
290317002938	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
290317002939	active site
290317002940	N-terminal domain interface [polypeptide binding]; other site
290317002941	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317002942	TPR motif; other site
290317002943	TPR repeat; Region: TPR_11; pfam13414
290317002944	binding surface
290317002945	TPR repeat; Region: TPR_11; pfam13414
290317002946	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317002947	binding surface
290317002948	TPR motif; other site
290317002949	TPR repeat; Region: TPR_11; pfam13414
290317002950	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
290317002951	TPR motif; other site
290317002952	binding surface
290317002953	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
290317002954	NADH dehydrogenase subunit B; Provisional; Region: PRK14813
290317002955	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
290317002956	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
290317002957	NADH dehydrogenase subunit D; Validated; Region: PRK06075
290317002958	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
290317002959	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
290317002960	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
290317002961	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
290317002962	NADH dehydrogenase subunit 6; Region: ndhG; CHL00016
290317002963	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
290317002964	NADH dehydrogenase subunit J; Provisional; Region: PRK06439
290317002965	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
290317002966	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
290317002967	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
290317002968	proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972
290317002969	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
290317002970	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
290317002971	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
290317002972	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
290317002973	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
290317002974	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
290317002975	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
290317002976	Ni/Fe-hydrogenase, b-type cytochrome subunit; Region: CytB-hydogenase; TIGR02125
290317002977	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
290317002978	nickel binding site [ion binding]; other site
290317002979	putative substrate-binding site; other site
290317002980	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
290317002981	homodecamer interface [polypeptide binding]; other site
290317002982	GTP cyclohydrolase I; Provisional; Region: PLN03044
290317002983	active site
290317002984	putative catalytic site residues [active]
290317002985	zinc binding site [ion binding]; other site
290317002986	GTP-CH-I/GFRP interaction surface; other site
290317002987	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
290317002988	active site
290317002989	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
290317002990	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
290317002991	catalytic residues [active]
290317002992	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; pfam06941
290317002993	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
290317002994	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
290317002995	putative RNA binding site [nucleotide binding]; other site
290317002996	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290317002997	S-adenosylmethionine binding site [chemical binding]; other site
290317002998	Domain of unknown function (DUF4292); Region: DUF4292; pfam14125
290317002999	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
290317003000	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
290317003001	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
290317003002	dephospho-CoA kinase; Provisional; Region: coaE; PRK14731
290317003003	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
290317003004	CoA-binding site [chemical binding]; other site
290317003005	ATP-binding [chemical binding]; other site
290317003006	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
290317003007	Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902
290317003008	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
290317003009	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
290317003010	substrate binding pocket [chemical binding]; other site
290317003011	chain length determination region; other site
290317003012	substrate-Mg2+ binding site; other site
290317003013	catalytic residues [active]
290317003014	aspartate-rich region 1; other site
290317003015	active site lid residues [active]
290317003016	aspartate-rich region 2; other site
290317003017	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
290317003018	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
290317003019	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
290317003020	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
290317003021	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
290317003022	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
290317003023	TM-ABC transporter signature motif; other site
290317003024	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
290317003025	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
290317003026	Walker A/P-loop; other site
290317003027	ATP binding site [chemical binding]; other site
290317003028	Q-loop/lid; other site
290317003029	ABC transporter signature motif; other site
290317003030	Walker B; other site
290317003031	D-loop; other site
290317003032	H-loop/switch region; other site
290317003033	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
290317003034	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202
290317003035	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
290317003036	putative NAD(P) binding site [chemical binding]; other site
290317003037	Membrane protein of unknown function; Region: DUF360; pfam04020
290317003038	DNA repair protein RadA; Provisional; Region: PRK11823
290317003039	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
290317003040	Walker A motif/ATP binding site; other site
290317003041	ATP binding site [chemical binding]; other site
290317003042	Walker B motif; other site
290317003043	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
290317003044	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14174
290317003045	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
290317003046	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
290317003047	homodimer interface [polypeptide binding]; other site
290317003048	NADP binding site [chemical binding]; other site
290317003049	substrate binding site [chemical binding]; other site
290317003050	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
290317003051	homotrimer interface [polypeptide binding]; other site
290317003052	Walker A motif; other site
290317003053	GTP binding site [chemical binding]; other site
290317003054	Walker B motif; other site
290317003055	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
290317003056	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
290317003057	putative dimer interface [polypeptide binding]; other site
290317003058	active site pocket [active]
290317003059	putative cataytic base [active]
290317003060	cobalamin synthase; Reviewed; Region: cobS; PRK00235
290317003061	OsmC-like protein; Region: OsmC; pfam02566
290317003062	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
290317003063	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323
290317003064	gating phenylalanine in ion channel; other site
290317003065	Predicted DNA-binding proteins [General function prediction only]; Region: COG1342
290317003066	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
290317003067	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183
290317003068	putative active site [active]
290317003069	metal binding site [ion binding]; metal-binding site
290317003070	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
290317003071	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
290317003072	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290317003073	Walker A/P-loop; other site
290317003074	ATP binding site [chemical binding]; other site
290317003075	Q-loop/lid; other site
290317003076	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
290317003077	ABC transporter signature motif; other site
290317003078	Walker B; other site
290317003079	D-loop; other site
290317003080	ABC transporter; Region: ABC_tran_2; pfam12848
290317003081	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
290317003082	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
290317003083	A new structural DNA glycosylase; Region: AlkD_like; cd06561
290317003084	active site
290317003085	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
290317003086	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
290317003087	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
290317003088	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
290317003089	active site
290317003090	HIGH motif; other site
290317003091	KMSKS motif; other site
290317003092	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
290317003093	tRNA binding surface [nucleotide binding]; other site
290317003094	anticodon binding site; other site
290317003095	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
290317003096	dimer interface [polypeptide binding]; other site
290317003097	putative tRNA-binding site [nucleotide binding]; other site
290317003098	PSP1 C-terminal conserved region; Region: PSP1; pfam04468
290317003099	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
290317003100	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551
290317003101	putative acyl-acceptor binding pocket; other site
290317003102	aspartate aminotransferase; Provisional; Region: PRK05764
290317003103	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
290317003104	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290317003105	homodimer interface [polypeptide binding]; other site
290317003106	catalytic residue [active]
290317003107	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
290317003108	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
290317003109	active site
290317003110	(T/H)XGH motif; other site
290317003111	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
290317003112	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290317003113	S-adenosylmethionine binding site [chemical binding]; other site
290317003114	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
290317003115	TPP-binding site [chemical binding]; other site
290317003116	dimer interface [polypeptide binding]; other site
290317003117	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
290317003118	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
290317003119	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
290317003120	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
290317003121	ATP binding site [chemical binding]; other site
290317003122	active site
290317003123	substrate binding site [chemical binding]; other site
290317003124	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
290317003125	putative catalytic site [active]
290317003126	putative metal binding site [ion binding]; other site
290317003127	putative phosphate binding site [ion binding]; other site
290317003128	Domain of unknown function (DUF1848); Region: DUF1848; pfam08902
290317003129	Pathogenicity locus; Region: Cdd1; pfam11731
290317003130	PAS domain; Region: PAS_9; pfam13426
290317003131	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
290317003132	putative active site [active]
290317003133	heme pocket [chemical binding]; other site
290317003134	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
290317003135	pyruvoyl-dependent arginine decarboxylase; Reviewed; Region: PRK01285
290317003136	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
290317003137	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
290317003138	active site
290317003139	DNA binding site [nucleotide binding]
290317003140	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
290317003141	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
290317003142	Catalytic site [active]
290317003143	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
290317003144	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
290317003145	putative acyl-acceptor binding pocket; other site
290317003146	phosphate binding protein; Region: ptsS_2; TIGR02136
290317003147	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
290317003148	PBP superfamily domain; Region: PBP_like_2; cl17296
290317003149	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
290317003150	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
290317003151	dimer interface [polypeptide binding]; other site
290317003152	conserved gate region; other site
290317003153	putative PBP binding loops; other site
290317003154	ABC-ATPase subunit interface; other site
290317003155	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
290317003156	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
290317003157	dimer interface [polypeptide binding]; other site
290317003158	conserved gate region; other site
290317003159	putative PBP binding loops; other site
290317003160	ABC-ATPase subunit interface; other site
290317003161	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14275
290317003162	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
290317003163	Walker A/P-loop; other site
290317003164	ATP binding site [chemical binding]; other site
290317003165	Q-loop/lid; other site
290317003166	ABC transporter signature motif; other site
290317003167	Walker B; other site
290317003168	D-loop; other site
290317003169	H-loop/switch region; other site
290317003170	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
290317003171	PhoU domain; Region: PhoU; pfam01895
290317003172	PhoU domain; Region: PhoU; pfam01895
290317003173	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
290317003174	PhoU domain; Region: PhoU; pfam01895
290317003175	PhoU domain; Region: PhoU; pfam01895
290317003176	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
290317003177	HlyD family secretion protein; Region: HlyD_3; pfam13437
290317003178	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
290317003179	DoxX-like family; Region: DoxX_3; pfam13781
290317003180	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
290317003181	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
290317003182	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
290317003183	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
290317003184	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
290317003185	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
290317003186	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
290317003187	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
290317003188	active site
290317003189	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
290317003190	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
290317003191	classical (c) SDRs; Region: SDR_c; cd05233
290317003192	NAD(P) binding site [chemical binding]; other site
290317003193	active site
290317003194	patatin-related protein; Region: TIGR03607
290317003195	Patatin-like phospholipase; Region: Patatin; pfam01734
290317003196	nucleophile elbow; other site
290317003197	Protein of unknown function (DUF3376); Region: DUF3376; pfam11856
290317003198	RmuC family; Region: RmuC; pfam02646
290317003199	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
290317003200	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
290317003201	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317003202	Walker A motif; other site
290317003203	ATP binding site [chemical binding]; other site
290317003204	Walker B motif; other site
290317003205	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
290317003206	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
290317003207	oxaloacetate decarboxylase alpha subunit; Region: oadA; TIGR01108
290317003208	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
290317003209	active site
290317003210	catalytic residues [active]
290317003211	metal binding site [ion binding]; metal-binding site
290317003212	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
290317003213	carboxyltransferase (CT) interaction site; other site
290317003214	biotinylation site [posttranslational modification]; other site
290317003215	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
290317003216	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
290317003217	ATP-grasp domain; Region: ATP-grasp_4; cl17255
290317003218	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
290317003219	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
290317003220	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
290317003221	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
290317003222	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
290317003223	active site
290317003224	motif I; other site
290317003225	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
290317003226	motif II; other site
290317003227	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
290317003228	Coenzyme A binding pocket [chemical binding]; other site
290317003229	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
290317003230	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
290317003231	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
290317003232	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
290317003233	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
290317003234	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290317003235	S-adenosylmethionine binding site [chemical binding]; other site
290317003236	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
290317003237	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290317003238	S-adenosylmethionine binding site [chemical binding]; other site
290317003239	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
290317003240	Transposase; Region: DDE_Tnp_ISL3; pfam01610
290317003241	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
290317003242	anti sigma factor interaction site; other site
290317003243	regulatory phosphorylation site [posttranslational modification]; other site
290317003244	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
290317003245	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
290317003246	Maf-like protein; Region: Maf; pfam02545
290317003247	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
290317003248	active site
290317003249	dimer interface [polypeptide binding]; other site
290317003250	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477
290317003251	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
290317003252	Na binding site [ion binding]; other site
290317003253	Ribokinase-like subgroup C.  Found only in bacteria, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_C; cd01946
290317003254	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
290317003255	substrate binding site [chemical binding]; other site
290317003256	ATP binding site [chemical binding]; other site
290317003257	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
290317003258	active site
290317003259	catalytic site [active]
290317003260	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
290317003261	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
290317003262	dimerization interface 3.5A [polypeptide binding]; other site
290317003263	active site
290317003264	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
290317003265	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
290317003266	N-acetyl-D-glucosamine binding site [chemical binding]; other site
290317003267	catalytic residue [active]
290317003268	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
290317003269	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
290317003270	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
290317003271	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
290317003272	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
290317003273	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
290317003274	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
290317003275	P loop; other site
290317003276	Nucleotide binding site [chemical binding]; other site
290317003277	DTAP/Switch II; other site
290317003278	Switch I; other site
290317003279	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
290317003280	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
290317003281	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
290317003282	ligand binding site [chemical binding]; other site
290317003283	NAD binding site [chemical binding]; other site
290317003284	dimerization interface [polypeptide binding]; other site
290317003285	catalytic site [active]
290317003286	ACT_3PGDH-like CD includes the C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-like; cd04879
290317003287	L-serine binding site [chemical binding]; other site
290317003288	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
290317003289	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
290317003290	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
290317003291	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
290317003292	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
290317003293	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
290317003294	ATP binding site [chemical binding]; other site
290317003295	Mg2+ binding site [ion binding]; other site
290317003296	G-X-G motif; other site
290317003297	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
290317003298	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
290317003299	active site
290317003300	dimer interface [polypeptide binding]; other site
290317003301	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
290317003302	dimer interface [polypeptide binding]; other site
290317003303	active site
290317003304	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
290317003305	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
290317003306	FtsX-like permease family; Region: FtsX; pfam02687
290317003307	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
290317003308	active site
290317003309	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
290317003310	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
290317003311	Walker A/P-loop; other site
290317003312	ATP binding site [chemical binding]; other site
290317003313	Q-loop/lid; other site
290317003314	ABC transporter signature motif; other site
290317003315	Walker B; other site
290317003316	D-loop; other site
290317003317	H-loop/switch region; other site
290317003318	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063
290317003319	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290317003320	NAD(P) binding site [chemical binding]; other site
290317003321	active site
290317003322	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
290317003323	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290317003324	NAD(P) binding site [chemical binding]; other site
290317003325	active site
290317003326	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
290317003327	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
290317003328	dimer interface [polypeptide binding]; other site
290317003329	active site
290317003330	Phosphopantetheine attachment site; Region: PP-binding; cl09936
290317003331	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
290317003332	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
290317003333	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
290317003334	adenylosuccinate lyase; Provisional; Region: PRK07492
290317003335	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
290317003336	tetramer interface [polypeptide binding]; other site
290317003337	active site
290317003338	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
290317003339	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
290317003340	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
290317003341	active site
290317003342	NTP binding site [chemical binding]; other site
290317003343	metal binding triad [ion binding]; metal-binding site
290317003344	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
290317003345	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
290317003346	Zn2+ binding site [ion binding]; other site
290317003347	Mg2+ binding site [ion binding]; other site
290317003348	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
290317003349	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
290317003350	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
290317003351	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290317003352	Major Facilitator Superfamily; Region: MFS_1; pfam07690
290317003353	putative substrate translocation pore; other site
290317003354	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
290317003355	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
290317003356	cobalamin binding residues [chemical binding]; other site
290317003357	putative BtuC binding residues; other site
290317003358	dimer interface [polypeptide binding]; other site
290317003359	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
290317003360	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
290317003361	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
290317003362	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
290317003363	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
290317003364	N-terminal plug; other site
290317003365	ligand-binding site [chemical binding]; other site
290317003366	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
290317003367	putative FMN binding site [chemical binding]; other site
290317003368	cobyric acid synthase; Provisional; Region: PRK00784
290317003369	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
290317003370	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
290317003371	catalytic triad [active]
290317003372	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
290317003373	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
290317003374	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290317003375	homodimer interface [polypeptide binding]; other site
290317003376	catalytic residue [active]
290317003377	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
290317003378	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572
290317003379	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
290317003380	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
290317003381	ABC-ATPase subunit  interface; other site
290317003382	dimer interface [polypeptide binding]; other site
290317003383	putative PBP binding regions; other site
290317003384	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
290317003385	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
290317003386	Walker A/P-loop; other site
290317003387	ATP binding site [chemical binding]; other site
290317003388	Q-loop/lid; other site
290317003389	ABC transporter signature motif; other site
290317003390	Walker B; other site
290317003391	D-loop; other site
290317003392	H-loop/switch region; other site
290317003393	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
290317003394	Protein of unknown function (DUF3465); Region: DUF3465; pfam11948
290317003395	DEAD-like helicases superfamily; Region: DEXDc; smart00487
290317003396	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290317003397	ATP binding site [chemical binding]; other site
290317003398	putative Mg++ binding site [ion binding]; other site
290317003399	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
290317003400	nucleotide binding region [chemical binding]; other site
290317003401	ATP-binding site [chemical binding]; other site
290317003402	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
290317003403	DNA protecting protein DprA; Region: dprA; TIGR00732
290317003404	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
290317003405	putative DNA binding site [nucleotide binding]; other site
290317003406	dimerization interface [polypeptide binding]; other site
290317003407	putative Zn2+ binding site [ion binding]; other site
290317003408	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
290317003409	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
290317003410	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290317003411	ATP binding site [chemical binding]; other site
290317003412	putative Mg++ binding site [ion binding]; other site
290317003413	Divergent AAA domain; Region: AAA_4; pfam04326
290317003414	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
290317003415	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
290317003416	HsdM N-terminal domain; Region: HsdM_N; pfam12161
290317003417	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
290317003418	Methyltransferase domain; Region: Methyltransf_26; pfam13659
290317003419	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
290317003420	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
290317003421	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
290317003422	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
290317003423	Integrase core domain; Region: rve; pfam00665
290317003424	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
290317003425	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317003426	Walker A motif; other site
290317003427	ATP binding site [chemical binding]; other site
290317003428	Walker B motif; other site
290317003429	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
290317003430	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
290317003431	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
290317003432	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
290317003433	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
290317003434	motif II; other site
290317003435	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
290317003436	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
290317003437	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
290317003438	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
290317003439	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
290317003440	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
290317003441	BRO family, N-terminal domain; Region: Bro-N; smart01040
290317003442	Winged helix-turn helix; Region: HTH_29; pfam13551
290317003443	Helix-turn-helix domain; Region: HTH_28; pfam13518
290317003444	Winged helix-turn helix; Region: HTH_33; pfam13592
290317003445	DDE superfamily endonuclease; Region: DDE_3; pfam13358
290317003446	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
290317003447	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
290317003448	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
290317003449	short chain dehydrogenase; Provisional; Region: PRK08267
290317003450	classical (c) SDRs; Region: SDR_c; cd05233
290317003451	NAD(P) binding site [chemical binding]; other site
290317003452	active site
290317003453	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290317003454	S-adenosylmethionine binding site [chemical binding]; other site
290317003455	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
290317003456	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
290317003457	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
290317003458	active site residues [active]
290317003459	dimer interface [polypeptide binding]; other site
290317003460	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
290317003461	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
290317003462	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
290317003463	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
290317003464	Ligand Binding Site [chemical binding]; other site
290317003465	membrane ATPase/protein kinase; Provisional; Region: PRK09435
290317003466	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
290317003467	Walker A; other site
290317003468	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
290317003469	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
290317003470	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
290317003471	active site
290317003472	substrate binding site [chemical binding]; other site
290317003473	coenzyme B12 binding site [chemical binding]; other site
290317003474	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
290317003475	B12 binding site [chemical binding]; other site
290317003476	cobalt ligand [ion binding]; other site
290317003477	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
290317003478	heterodimer interface [polypeptide binding]; other site
290317003479	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
290317003480	substrate interaction site [chemical binding]; other site
290317003481	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
290317003482	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
290317003483	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
290317003484	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
290317003485	dimer interface [polypeptide binding]; other site
290317003486	substrate binding site [chemical binding]; other site
290317003487	metal binding site [ion binding]; metal-binding site
290317003488	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
290317003489	Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967
290317003490	acyl-activating enzyme (AAE) consensus motif; other site
290317003491	putative AMP binding site [chemical binding]; other site
290317003492	putative active site [active]
290317003493	putative CoA binding site [chemical binding]; other site
290317003494	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
290317003495	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290317003496	S-adenosylmethionine binding site [chemical binding]; other site
290317003497	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
290317003498	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
290317003499	PYR/PP interface [polypeptide binding]; other site
290317003500	dimer interface [polypeptide binding]; other site
290317003501	TPP binding site [chemical binding]; other site
290317003502	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
290317003503	hypothetical protein; Provisional; Region: PRK14621
290317003504	recombination protein RecR; Reviewed; Region: recR; PRK00076
290317003505	RecR protein; Region: RecR; pfam02132
290317003506	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
290317003507	putative active site [active]
290317003508	putative metal-binding site [ion binding]; other site
290317003509	tetramer interface [polypeptide binding]; other site
290317003510	phytoene desaturase; Region: phytoene_desat; TIGR02731
290317003511	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
290317003512	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290317003513	FeS/SAM binding site; other site
290317003514	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
290317003515	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
290317003516	G1 box; other site
290317003517	putative GEF interaction site [polypeptide binding]; other site
290317003518	GTP/Mg2+ binding site [chemical binding]; other site
290317003519	Switch I region; other site
290317003520	G2 box; other site
290317003521	G3 box; other site
290317003522	Switch II region; other site
290317003523	G4 box; other site
290317003524	G5 box; other site
290317003525	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
290317003526	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
290317003527	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
290317003528	membrane-bound complex binding site; other site
290317003529	hinge residues; other site
290317003530	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
290317003531	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
290317003532	substrate binding pocket [chemical binding]; other site
290317003533	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
290317003534	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
290317003535	dimer interface [polypeptide binding]; other site
290317003536	conserved gate region; other site
290317003537	putative PBP binding loops; other site
290317003538	ABC-ATPase subunit interface; other site
290317003539	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
290317003540	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
290317003541	Walker A/P-loop; other site
290317003542	ATP binding site [chemical binding]; other site
290317003543	Q-loop/lid; other site
290317003544	ABC transporter signature motif; other site
290317003545	Walker B; other site
290317003546	D-loop; other site
290317003547	H-loop/switch region; other site
290317003548	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
290317003549	dimer interface [polypeptide binding]; other site
290317003550	substrate binding site [chemical binding]; other site
290317003551	metal binding sites [ion binding]; metal-binding site
290317003552	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
290317003553	fumarate hydratase; Reviewed; Region: fumC; PRK00485
290317003554	Class II fumarases; Region: Fumarase_classII; cd01362
290317003555	active site
290317003556	tetramer interface [polypeptide binding]; other site
290317003557	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
290317003558	pseudaminic acid synthase; Region: PseI; TIGR03586
290317003559	NeuB family; Region: NeuB; pfam03102
290317003560	heat shock protein 90; Provisional; Region: PRK05218
290317003561	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290317003562	ATP binding site [chemical binding]; other site
290317003563	Mg2+ binding site [ion binding]; other site
290317003564	G-X-G motif; other site
290317003565	Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044
290317003566	diiron binding motif [ion binding]; other site
290317003567	CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431
290317003568	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
290317003569	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
290317003570	AAA domain; Region: AAA_33; pfam13671
290317003571	active site
290317003572	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
290317003573	Fumarase C-terminus; Region: Fumerase_C; pfam05683
290317003574	Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016
290317003575	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
290317003576	active site
290317003577	catalytic residues [active]
290317003578	metal binding site [ion binding]; metal-binding site
290317003579	homodimer binding site [polypeptide binding]; other site
290317003580	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
290317003581	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
290317003582	carboxyltransferase (CT) interaction site; other site
290317003583	biotinylation site [posttranslational modification]; other site
290317003584	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
290317003585	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
290317003586	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
290317003587	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
290317003588	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
290317003589	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
290317003590	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
290317003591	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
290317003592	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
290317003593	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
290317003594	active site
290317003595	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
290317003596	generic binding surface II; other site
290317003597	generic binding surface I; other site
290317003598	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
290317003599	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
290317003600	catalytic residues [active]
290317003601	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
290317003602	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
290317003603	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
290317003604	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
290317003605	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
290317003606	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
290317003607	putative active site [active]
290317003608	putative metal binding site [ion binding]; other site
290317003609	SdiA-regulated; Region: SdiA-regulated; cd09971
290317003610	putative active site [active]
290317003611	Surface antigen; Region: Bac_surface_Ag; pfam01103
290317003612	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
290317003613	Autotransporter beta-domain; Region: Autotransporter; smart00869
290317003614	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
290317003615	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290317003616	active site
290317003617	phosphorylation site [posttranslational modification]
290317003618	intermolecular recognition site; other site
290317003619	dimerization interface [polypeptide binding]; other site
290317003620	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
290317003621	DNA binding site [nucleotide binding]
290317003622	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
290317003623	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
290317003624	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
290317003625	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
290317003626	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
290317003627	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
290317003628	ligand binding site [chemical binding]; other site
290317003629	four helix bundle suffix domain; Region: 4helix_suffix; TIGR04258
290317003630	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
290317003631	Protein of unknown function (DUF1778); Region: DUF1778; pfam08681
290317003632	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
290317003633	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
290317003634	Coenzyme A binding pocket [chemical binding]; other site
290317003635	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
290317003636	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317003637	Walker A motif; other site
290317003638	ATP binding site [chemical binding]; other site
290317003639	Walker B motif; other site
290317003640	arginine finger; other site
290317003641	Predicted transcriptional regulator [Transcription]; Region: COG3905
290317003642	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
290317003643	Transposase, Mutator family; Region: Transposase_mut; pfam00872
290317003644	MULE transposase domain; Region: MULE; pfam10551
290317003645	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
290317003646	Part of AAA domain; Region: AAA_19; pfam13245
290317003647	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
290317003648	AAA domain; Region: AAA_12; pfam13087
290317003649	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
290317003650	putative active site [active]
290317003651	Protein of unknown function (DUF3320); Region: DUF3320; pfam11784
290317003652	Transposase; Region: DEDD_Tnp_IS110; pfam01548
290317003653	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
290317003654	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
290317003655	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
290317003656	PemK-like protein; Region: PemK; pfam02452
290317003657	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_6; cd06256
290317003658	putative active site [active]
290317003659	Zn binding site [ion binding]; other site
290317003660	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290317003661	PAS fold; Region: PAS_3; pfam08447
290317003662	putative active site [active]
290317003663	heme pocket [chemical binding]; other site
290317003664	PAS domain S-box; Region: sensory_box; TIGR00229
290317003665	SNF2 Helicase protein; Region: DUF3670; pfam12419
290317003666	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
290317003667	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290317003668	ATP binding site [chemical binding]; other site
290317003669	putative Mg++ binding site [ion binding]; other site
290317003670	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
290317003671	nucleotide binding region [chemical binding]; other site
290317003672	ATP-binding site [chemical binding]; other site
290317003673	Uncharacterized conserved protein [Function unknown]; Region: COG4279
290317003674	SWIM zinc finger; Region: SWIM; pfam04434
290317003675	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
290317003676	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
290317003677	motif II; other site
290317003678	Methyltransferase domain; Region: Methyltransf_31; pfam13847
290317003679	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290317003680	S-adenosylmethionine binding site [chemical binding]; other site
290317003681	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
290317003682	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
290317003683	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
290317003684	HlyD family secretion protein; Region: HlyD_3; pfam13437
290317003685	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
290317003686	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
290317003687	FtsX-like permease family; Region: FtsX; pfam02687
290317003688	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
290317003689	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
290317003690	Walker A/P-loop; other site
290317003691	ATP binding site [chemical binding]; other site
290317003692	Q-loop/lid; other site
290317003693	ABC transporter signature motif; other site
290317003694	Walker B; other site
290317003695	D-loop; other site
290317003696	H-loop/switch region; other site
290317003697	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
290317003698	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
290317003699	putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862
290317003700	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
290317003701	Cl- selectivity filter; other site
290317003702	Cl- binding residues [ion binding]; other site
290317003703	pore gating glutamate residue; other site
290317003704	dimer interface [polypeptide binding]; other site
290317003705	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613
290317003706	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290317003707	PAS domain; Region: PAS_9; pfam13426
290317003708	putative active site [active]
290317003709	heme pocket [chemical binding]; other site
290317003710	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
290317003711	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
290317003712	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
290317003713	P loop; other site
290317003714	Nucleotide binding site [chemical binding]; other site
290317003715	DTAP/Switch II; other site
290317003716	Switch I; other site
290317003717	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
290317003718	Vibrio cholerae toxin co-regulated pilus biosynthesis protein F; Region: TcpF; pfam06340
290317003719	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
290317003720	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
290317003721	ATP binding site [chemical binding]; other site
290317003722	Mg++ binding site [ion binding]; other site
290317003723	motif III; other site
290317003724	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
290317003725	nucleotide binding region [chemical binding]; other site
290317003726	ATP-binding site [chemical binding]; other site
290317003727	PAS domain; Region: PAS_9; pfam13426
290317003728	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
290317003729	putative active site [active]
290317003730	heme pocket [chemical binding]; other site
290317003731	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
290317003732	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
290317003733	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290317003734	active site
290317003735	phosphorylation site [posttranslational modification]
290317003736	intermolecular recognition site; other site
290317003737	dimerization interface [polypeptide binding]; other site
290317003738	nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
290317003739	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290317003740	putative active site [active]
290317003741	heme pocket [chemical binding]; other site
290317003742	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290317003743	putative active site [active]
290317003744	heme pocket [chemical binding]; other site
290317003745	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290317003746	dimer interface [polypeptide binding]; other site
290317003747	phosphorylation site [posttranslational modification]
290317003748	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290317003749	ATP binding site [chemical binding]; other site
290317003750	Mg2+ binding site [ion binding]; other site
290317003751	G-X-G motif; other site
290317003752	Caspase domain; Region: Peptidase_C14; pfam00656
290317003753	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
290317003754	FAD binding domain; Region: FAD_binding_4; pfam01565
290317003755	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
290317003756	Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627
290317003757	putative heme binding site [chemical binding]; other site
290317003758	cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345
290317003759	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
290317003760	FAD binding pocket [chemical binding]; other site
290317003761	FAD binding motif [chemical binding]; other site
290317003762	phosphate binding motif [ion binding]; other site
290317003763	beta-alpha-beta structure motif; other site
290317003764	NAD binding pocket [chemical binding]; other site
290317003765	Iron coordination center [ion binding]; other site
290317003766	4Fe-4S dicluster domain; Region: Fer4_18; pfam13746
290317003767	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
290317003768	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
290317003769	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
290317003770	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
290317003771	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
290317003772	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
290317003773	Cysteine-rich domain; Region: CCG; pfam02754
290317003774	Cysteine-rich domain; Region: CCG; pfam02754
290317003775	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
290317003776	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
290317003777	aspartate aminotransferase; Provisional; Region: PRK08636
290317003778	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
290317003779	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290317003780	homodimer interface [polypeptide binding]; other site
290317003781	catalytic residue [active]
290317003782	Uncharacterized conserved protein [Function unknown]; Region: COG0062
290317003783	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
290317003784	putative substrate binding site [chemical binding]; other site
290317003785	putative ATP binding site [chemical binding]; other site
290317003786	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
290317003787	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
290317003788	dimerization interface [polypeptide binding]; other site
290317003789	ATP binding site [chemical binding]; other site
290317003790	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
290317003791	dimerization interface [polypeptide binding]; other site
290317003792	ATP binding site [chemical binding]; other site
290317003793	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12900
290317003794	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
290317003795	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
290317003796	nucleotide binding region [chemical binding]; other site
290317003797	ATP-binding site [chemical binding]; other site
290317003798	SEC-C motif; Region: SEC-C; pfam02810
290317003799	8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934
290317003800	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
290317003801	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
290317003802	helix-hairpin-helix signature motif; other site
290317003803	substrate binding pocket [chemical binding]; other site
290317003804	active site
290317003805	Cytochrome c; Region: Cytochrom_C; pfam00034
290317003806	Domain of unknown function (DUF4405); Region: DUF4405; pfam14358
290317003807	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
290317003808	Malic enzyme, N-terminal domain; Region: malic; pfam00390
290317003809	Malic enzyme, NAD binding domain; Region: Malic_M; smart00919
290317003810	NAD(P) binding pocket [chemical binding]; other site
290317003811	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
290317003812	Domain of unknown function (DUF4403); Region: DUF4403; pfam14356
290317003813	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
290317003814	NADH(P)-binding; Region: NAD_binding_10; pfam13460
290317003815	NAD(P) binding site [chemical binding]; other site
290317003816	putative active site [active]
290317003817	lipoyl synthase; Provisional; Region: PRK05481
290317003818	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
290317003819	FeS/SAM binding site; other site
290317003820	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
290317003821	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317003822	Walker A motif; other site
290317003823	ATP binding site [chemical binding]; other site
290317003824	Walker B motif; other site
290317003825	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
290317003826	Integrase core domain; Region: rve; pfam00665
290317003827	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
290317003828	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
290317003829	non-specific DNA binding site [nucleotide binding]; other site
290317003830	salt bridge; other site
290317003831	sequence-specific DNA binding site [nucleotide binding]; other site
290317003832	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
290317003833	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
290317003834	Predicted transcriptional regulator [Transcription]; Region: COG2944
290317003835	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
290317003836	Abi-like protein; Region: Abi_2; cl01988
290317003837	SIR2-like domain; Region: SIR2_2; pfam13289
290317003838	HerA helicase [Replication, recombination, and repair]; Region: COG0433
290317003839	Domain of unknown function DUF87; Region: DUF87; pfam01935
290317003840	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290317003841	ABC transporter signature motif; other site
290317003842	Walker B; other site
290317003843	D-loop; other site
290317003844	H-loop/switch region; other site
290317003845	KTSC domain; Region: KTSC; pfam13619
290317003846	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
290317003847	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
290317003848	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
290317003849	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
290317003850	TIR domain; Region: TIR_2; pfam13676
290317003851	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
290317003852	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
290317003853	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
290317003854	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290317003855	NACHT domain; Region: NACHT; pfam05729
290317003856	Walker A/P-loop; other site
290317003857	ATP binding site [chemical binding]; other site
290317003858	Uncharacterized conserved protein [Function unknown]; Region: COG1262
290317003859	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
290317003860	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
290317003861	DEAD-like helicases superfamily; Region: DEXDc; smart00487
290317003862	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290317003863	ATP binding site [chemical binding]; other site
290317003864	putative Mg++ binding site [ion binding]; other site
290317003865	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
290317003866	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
290317003867	nucleotide binding region [chemical binding]; other site
290317003868	ATP-binding site [chemical binding]; other site
290317003869	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
290317003870	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290317003871	ATP binding site [chemical binding]; other site
290317003872	putative Mg++ binding site [ion binding]; other site
290317003873	helicase superfamily c-terminal domain; Region: HELICc; smart00490
290317003874	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
290317003875	carboxy-terminal protease; Provisional; Region: PRK11186
290317003876	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
290317003877	protein binding site [polypeptide binding]; other site
290317003878	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
290317003879	Catalytic dyad [active]
290317003880	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
290317003881	CoA binding domain; Region: CoA_binding; smart00881
290317003882	ATP citrate (pro-S)-lyase; Region: PLN02522
290317003883	CoA-ligase; Region: Ligase_CoA; pfam00549
290317003884	Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100
290317003885	active site
290317003886	oxalacetate binding site [chemical binding]; other site
290317003887	citrylCoA binding site [chemical binding]; other site
290317003888	coenzyme A binding site [chemical binding]; other site
290317003889	catalytic triad [active]
290317003890	Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045
290317003891	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
290317003892	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
290317003893	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
290317003894	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
290317003895	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
290317003896	Walker A/P-loop; other site
290317003897	ATP binding site [chemical binding]; other site
290317003898	Q-loop/lid; other site
290317003899	ABC transporter signature motif; other site
290317003900	Walker B; other site
290317003901	D-loop; other site
290317003902	H-loop/switch region; other site
290317003903	Domain of unknown function DUF87; Region: DUF87; pfam01935
290317003904	HerA helicase [Replication, recombination, and repair]; Region: COG0433
290317003905	Predicted membrane protein [Function unknown]; Region: COG2119
290317003906	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
290317003907	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
290317003908	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
290317003909	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
290317003910	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
290317003911	Coenzyme A binding pocket [chemical binding]; other site
290317003912	Rubredoxin [Energy production and conversion]; Region: COG1773
290317003913	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
290317003914	iron binding site [ion binding]; other site
290317003915	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
290317003916	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
290317003917	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
290317003918	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
290317003919	FtsX-like permease family; Region: FtsX; pfam02687
290317003920	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
290317003921	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
290317003922	metal binding site [ion binding]; metal-binding site
290317003923	active site
290317003924	I-site; other site
290317003925	PBP superfamily domain; Region: PBP_like_2; pfam12849
290317003926	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
290317003927	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
290317003928	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
290317003929	heterotetramer interface [polypeptide binding]; other site
290317003930	active site pocket [active]
290317003931	cleavage site
290317003932	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
290317003933	feedback inhibition sensing region; other site
290317003934	homohexameric interface [polypeptide binding]; other site
290317003935	nucleotide binding site [chemical binding]; other site
290317003936	N-acetyl-L-glutamate binding site [chemical binding]; other site
290317003937	ornithine carbamoyltransferase; Provisional; Region: PRK00779
290317003938	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
290317003939	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
290317003940	Arginine repressor [Transcription]; Region: ArgR; COG1438
290317003941	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
290317003942	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
290317003943	argininosuccinate synthase; Provisional; Region: PRK13820
290317003944	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
290317003945	ANP binding site [chemical binding]; other site
290317003946	Substrate Binding Site II [chemical binding]; other site
290317003947	Substrate Binding Site I [chemical binding]; other site
290317003948	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
290317003949	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
290317003950	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
290317003951	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
290317003952	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
290317003953	argininosuccinate lyase; Provisional; Region: PRK00855
290317003954	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
290317003955	active sites [active]
290317003956	tetramer interface [polypeptide binding]; other site
290317003957	carboxy-terminal protease; Provisional; Region: PRK11186
290317003958	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
290317003959	protein binding site [polypeptide binding]; other site
290317003960	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
290317003961	Catalytic dyad [active]
290317003962	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
290317003963	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
290317003964	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
290317003965	intersubunit interface [polypeptide binding]; other site
290317003966	active site
290317003967	zinc binding site [ion binding]; other site
290317003968	Na+ binding site [ion binding]; other site
290317003969	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
290317003970	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
290317003971	metal binding site [ion binding]; metal-binding site
290317003972	dimer interface [polypeptide binding]; other site
290317003973	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
290317003974	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
290317003975	polyphosphate kinase; Provisional; Region: PRK05443
290317003976	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
290317003977	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
290317003978	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
290317003979	putative domain interface [polypeptide binding]; other site
290317003980	putative active site [active]
290317003981	catalytic site [active]
290317003982	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
290317003983	putative domain interface [polypeptide binding]; other site
290317003984	putative active site [active]
290317003985	catalytic site [active]
290317003986	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
290317003987	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
290317003988	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
290317003989	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
290317003990	dihydroorotase; Validated; Region: pyrC; PRK09357
290317003991	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
290317003992	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
290317003993	active site
290317003994	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
290317003995	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290317003996	S-adenosylmethionine binding site [chemical binding]; other site
290317003997	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
290317003998	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
290317003999	putative NADP binding site [chemical binding]; other site
290317004000	putative substrate binding site [chemical binding]; other site
290317004001	active site
290317004002	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
290317004003	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
290317004004	ligand binding site [chemical binding]; other site
290317004005	CHAD domain; Region: CHAD; pfam05235
290317004006	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
290317004007	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
290317004008	P-loop; other site
290317004009	Magnesium ion binding site [ion binding]; other site
290317004010	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
290317004011	Magnesium ion binding site [ion binding]; other site
290317004012	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
290317004013	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
290317004014	NlpC/P60 family; Region: NLPC_P60; pfam00877
290317004015	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
290317004016	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317004017	Walker A motif; other site
290317004018	ATP binding site [chemical binding]; other site
290317004019	Walker B motif; other site
290317004020	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
290317004021	Integrase core domain; Region: rve; pfam00665
290317004022	Pleckstrin homology-like domain; Region: PH-like; cl17171
290317004023	Cupin domain; Region: Cupin_2; pfam07883
290317004024	DDE superfamily endonuclease; Region: DDE_3; pfam13358
290317004025	Winged helix-turn helix; Region: HTH_29; pfam13551
290317004026	Winged helix-turn helix; Region: HTH_33; pfam13592
290317004027	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
290317004028	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
290317004029	AAA domain; Region: AAA_23; pfam13476
290317004030	Walker A/P-loop; other site
290317004031	ATP binding site [chemical binding]; other site
290317004032	Q-loop/lid; other site
290317004033	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
290317004034	ABC transporter signature motif; other site
290317004035	Walker B; other site
290317004036	D-loop; other site
290317004037	H-loop/switch region; other site
290317004038	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
290317004039	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290317004040	putative ADP-binding pocket [chemical binding]; other site
290317004041	YXWGXW repeat (2 copies); Region: YXWGXW; pfam12779
290317004042	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250
290317004043	30S subunit binding site; other site
290317004044	Winged helix-turn helix; Region: HTH_29; pfam13551
290317004045	Winged helix-turn helix; Region: HTH_33; pfam13592
290317004046	DDE superfamily endonuclease; Region: DDE_3; pfam13358
290317004047	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
290317004048	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
290317004049	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
290317004050	exonuclease subunit SbcD; Provisional; Region: PRK10966
290317004051	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
290317004052	active site
290317004053	metal binding site [ion binding]; metal-binding site
290317004054	DNA binding site [nucleotide binding]
290317004055	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
290317004056	Ion channel; Region: Ion_trans_2; pfam07885
290317004057	toxin interface [polypeptide binding]; other site
290317004058	putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830
290317004059	YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831
290317004060	Zn binding site [ion binding]; other site
290317004061	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
290317004062	non-specific DNA binding site [nucleotide binding]; other site
290317004063	salt bridge; other site
290317004064	sequence-specific DNA binding site [nucleotide binding]; other site
290317004065	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
290317004066	Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710
290317004067	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
290317004068	PemK-like protein; Region: PemK; pfam02452
290317004069	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
290317004070	PIN domain; Region: PIN_3; cl17397
290317004071	Winged helix-turn helix; Region: HTH_29; pfam13551
290317004072	Winged helix-turn helix; Region: HTH_33; pfam13592
290317004073	DDE superfamily endonuclease; Region: DDE_3; pfam13358
290317004074	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
290317004075	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
290317004076	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
290317004077	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
290317004078	PemK-like protein; Region: PemK; pfam02452
290317004079	Protein of unknown function (DUF3018); Region: DUF3018; pfam11455
290317004080	Transposase IS200 like; Region: Y1_Tnp; cl00848
290317004081	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
290317004082	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
290317004083	putative active site [active]
290317004084	putative metal binding site [ion binding]; other site
290317004085	Coronavirus S1 glycoprotein; Region: Corona_S1; pfam01600
290317004086	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
290317004087	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
290317004088	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
290317004089	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
290317004090	Divergent AAA domain; Region: AAA_4; pfam04326
290317004091	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
290317004092	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
290317004093	AAA domain; Region: AAA_30; pfam13604
290317004094	Family description; Region: UvrD_C_2; pfam13538
290317004095	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
290317004096	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
290317004097	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
290317004098	Bacterial PH domain; Region: DUF304; pfam03703
290317004099	Domain of unknown function (DUF389); Region: DUF389; pfam04087
290317004100	Transcriptional regulator; Region: Rrf2; cl17282
290317004101	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
290317004102	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
290317004103	sequence-specific DNA binding site [nucleotide binding]; other site
290317004104	salt bridge; other site
290317004105	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
290317004106	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
290317004107	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
290317004108	putative active site [active]
290317004109	catalytic residue [active]
290317004110	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
290317004111	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
290317004112	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
290317004113	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
290317004114	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
290317004115	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290317004116	homodimer interface [polypeptide binding]; other site
290317004117	catalytic residue [active]
290317004118	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
290317004119	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
290317004120	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
290317004121	NADP binding site [chemical binding]; other site
290317004122	homopentamer interface [polypeptide binding]; other site
290317004123	substrate binding site [chemical binding]; other site
290317004124	active site
290317004125	PhoH-like protein; Region: PhoH; pfam02562
290317004126	benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224
290317004127	benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224
290317004128	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
290317004129	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
290317004130	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
290317004131	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
290317004132	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
290317004133	putative FMN binding site [chemical binding]; other site
290317004134	NADPH bind site [chemical binding]; other site
290317004135	Transposase IS200 like; Region: Y1_Tnp; cl00848
290317004136	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
290317004137	Transposase IS200 like; Region: Y1_Tnp; cl00848
290317004138	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
290317004139	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317004140	Walker A motif; other site
290317004141	ATP binding site [chemical binding]; other site
290317004142	Walker B motif; other site
290317004143	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
290317004144	Integrase core domain; Region: rve; pfam00665
290317004145	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
290317004146	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721
290317004147	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637
290317004148	CRISPR-associated protein Cas7/Csd2, subtype I-C/DVULG; Region: cas_Csd2; TIGR02589
290317004149	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757
290317004150	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752
290317004151	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
290317004152	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
290317004153	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
290317004154	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
290317004155	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
290317004156	Predicted transcriptional regulator [Transcription]; Region: COG2378
290317004157	WYL domain; Region: WYL; pfam13280
290317004158	Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983
290317004159	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
290317004160	YcfA-like protein; Region: YcfA; pfam07927
290317004161	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924
290317004162	Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795
290317004163	Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983
290317004164	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
290317004165	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
290317004166	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
290317004167	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
290317004168	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
290317004169	bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566
290317004170	UbiA prenyltransferase family; Region: UbiA; pfam01040
290317004171	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
290317004172	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
290317004173	active site
290317004174	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
290317004175	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317004176	Walker A motif; other site
290317004177	ATP binding site [chemical binding]; other site
290317004178	Walker B motif; other site
290317004179	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
290317004180	Integrase core domain; Region: rve; pfam00665
290317004181	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
290317004182	zinc transporter ZupT; Provisional; Region: PRK04201
290317004183	ZIP Zinc transporter; Region: Zip; pfam02535
290317004184	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
290317004185	Predicted DNA-binding proteins [General function prediction only]; Region: COG1342
290317004186	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
290317004187	DNA binding residues [nucleotide binding]
290317004188	Domain of unknown function (DUF4379); Region: DUF4379; pfam14311
290317004189	bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550
290317004190	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
290317004191	methionine sulfoxide reductase A; Provisional; Region: PRK14054
290317004192	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
290317004193	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
290317004194	catalytic residues [active]
290317004195	D-glucuronyl C5-epimerase C-terminus; Region: C5-epim_C; pfam06662
290317004196	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
290317004197	FAD binding pocket [chemical binding]; other site
290317004198	FAD binding motif [chemical binding]; other site
290317004199	phosphate binding motif [ion binding]; other site
290317004200	beta-alpha-beta structure motif; other site
290317004201	NAD binding pocket [chemical binding]; other site
290317004202	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822
290317004203	putative hydrophobic ligand binding site [chemical binding]; other site
290317004204	Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365
290317004205	aminoacyl-tRNA ligase; Region: PLN02563
290317004206	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
290317004207	FMN binding site [chemical binding]; other site
290317004208	dimer interface [polypeptide binding]; other site
290317004209	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
290317004210	CoenzymeA binding site [chemical binding]; other site
290317004211	subunit interaction site [polypeptide binding]; other site
290317004212	PHB binding site; other site
290317004213	SEC-C motif; Region: SEC-C; pfam02810
290317004214	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
290317004215	dimer interface [polypeptide binding]; other site
290317004216	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
290317004217	Winged helix-turn helix; Region: HTH_29; pfam13551
290317004218	Homeodomain-like domain; Region: HTH_23; pfam13384
290317004219	Homeodomain-like domain; Region: HTH_32; pfam13565
290317004220	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820
290317004221	Insecticidal Crystal Toxin, P42; Region: Toxin_10; pfam05431
290317004222	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
290317004223	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
290317004224	putative active site [active]
290317004225	putative NTP binding site [chemical binding]; other site
290317004226	putative nucleic acid binding site [nucleotide binding]; other site
290317004227	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
290317004228	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
290317004229	Integrase core domain; Region: rve; pfam00665
290317004230	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
290317004231	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317004232	Walker A motif; other site
290317004233	ATP binding site [chemical binding]; other site
290317004234	Walker B motif; other site
290317004235	Transposase IS200 like; Region: Y1_Tnp; cl00848
290317004236	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
290317004237	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
290317004238	putative NTP binding site [chemical binding]; other site
290317004239	Transposase IS200 like; Region: Y1_Tnp; cl00848
290317004240	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
290317004241	putative DNA binding site [nucleotide binding]; other site
290317004242	putative Zn2+ binding site [ion binding]; other site
290317004243	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290317004244	ATP binding site [chemical binding]; other site
290317004245	Mg2+ binding site [ion binding]; other site
290317004246	G-X-G motif; other site
290317004247	Domain of unknown function (DUF4325); Region: DUF4325; pfam14213
290317004248	Uncharacterized conserved protein [Function unknown]; Region: COG1262
290317004249	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
290317004250	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
290317004251	HsdM N-terminal domain; Region: HsdM_N; pfam12161
290317004252	Methyltransferase domain; Region: Methyltransf_26; pfam13659
290317004253	EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737
290317004254	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
290317004255	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
290317004256	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290317004257	FeS/SAM binding site; other site
290317004258	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
290317004259	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
290317004260	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290317004261	ATP binding site [chemical binding]; other site
290317004262	putative Mg++ binding site [ion binding]; other site
290317004263	Methyltransferase domain; Region: Methyltransf_26; pfam13659
290317004264	XamI restriction endonuclease; Region: RE_XamI; pfam09572
290317004265	Domain of unknown function (DUF4411); Region: DUF4411; pfam14367
290317004266	Domain of unknown function (DUF955); Region: DUF955; cl01076
290317004267	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
290317004268	HlyD family secretion protein; Region: HlyD_3; pfam13437
290317004269	FtsX-like permease family; Region: FtsX; pfam02687
290317004270	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
290317004271	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
290317004272	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
290317004273	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
290317004274	Walker A/P-loop; other site
290317004275	ATP binding site [chemical binding]; other site
290317004276	Q-loop/lid; other site
290317004277	ABC transporter signature motif; other site
290317004278	Walker B; other site
290317004279	D-loop; other site
290317004280	H-loop/switch region; other site
290317004281	amino acid transporter; Region: 2A0306; TIGR00909
290317004282	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
290317004283	Protein of unknown function (DUF3683); Region: DUF3683; pfam12447
290317004284	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
290317004285	FAD binding domain; Region: FAD_binding_4; pfam01565
290317004286	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
290317004287	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
290317004288	Cysteine-rich domain; Region: CCG; pfam02754
290317004289	Cysteine-rich domain; Region: CCG; pfam02754
290317004290	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
290317004291	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
290317004292	inhibitor-cofactor binding pocket; inhibition site
290317004293	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290317004294	catalytic residue [active]
290317004295	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
290317004296	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
290317004297	active site
290317004298	NAD binding site [chemical binding]; other site
290317004299	metal binding site [ion binding]; metal-binding site
290317004300	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
290317004301	ligand binding site; other site
290317004302	tetramer interface; other site
290317004303	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
290317004304	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
290317004305	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
290317004306	DNA methylase; Region: N6_N4_Mtase; pfam01555
290317004307	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
290317004308	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
290317004309	acyl-activating enzyme (AAE) consensus motif; other site
290317004310	putative AMP binding site [chemical binding]; other site
290317004311	putative active site [active]
290317004312	putative CoA binding site [chemical binding]; other site
290317004313	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
290317004314	endonuclease III; Region: ENDO3c; smart00478
290317004315	minor groove reading motif; other site
290317004316	helix-hairpin-helix signature motif; other site
290317004317	substrate binding pocket [chemical binding]; other site
290317004318	active site
290317004319	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
290317004320	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
290317004321	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
290317004322	RimM N-terminal domain; Region: RimM; pfam01782
290317004323	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
290317004324	signal recognition particle protein; Provisional; Region: PRK10867
290317004325	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
290317004326	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
290317004327	P loop; other site
290317004328	GTP binding site [chemical binding]; other site
290317004329	Signal peptide binding domain; Region: SRP_SPB; pfam02978
290317004330	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
290317004331	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
290317004332	putative ribose interaction site [chemical binding]; other site
290317004333	putative ADP binding site [chemical binding]; other site
290317004334	Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876
290317004335	putative lipid binding site [chemical binding]; other site
290317004336	Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876
290317004337	putative lipid binding site [chemical binding]; other site
290317004338	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
290317004339	C-terminal peptidase (prc); Region: prc; TIGR00225
290317004340	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
290317004341	protein binding site [polypeptide binding]; other site
290317004342	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
290317004343	Catalytic dyad [active]
290317004344	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
290317004345	homotrimer interaction site [polypeptide binding]; other site
290317004346	putative active site [active]
290317004347	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
290317004348	thiamine phosphate binding site [chemical binding]; other site
290317004349	active site
290317004350	pyrophosphate binding site [ion binding]; other site
290317004351	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
290317004352	thiamine phosphate binding site [chemical binding]; other site
290317004353	active site
290317004354	pyrophosphate binding site [ion binding]; other site
290317004355	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
290317004356	dimer interface [polypeptide binding]; other site
290317004357	substrate binding site [chemical binding]; other site
290317004358	ATP binding site [chemical binding]; other site
290317004359	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
290317004360	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
290317004361	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
290317004362	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
290317004363	Biogenesis of lysosome-related organelles complex-1 subunit 2; Region: BLOC1_2; pfam10046
290317004364	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
290317004365	multifunctional aminopeptidase A; Provisional; Region: PRK00913
290317004366	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
290317004367	interface (dimer of trimers) [polypeptide binding]; other site
290317004368	Substrate-binding/catalytic site; other site
290317004369	Zn-binding sites [ion binding]; other site
290317004370	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
290317004371	DHH family; Region: DHH; pfam01368
290317004372	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14456
290317004373	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290317004374	FeS/SAM binding site; other site
290317004375	adenylate kinase; Reviewed; Region: adk; PRK00279
290317004376	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
290317004377	AMP-binding site [chemical binding]; other site
290317004378	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
290317004379	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290317004380	primosomal protein N' Region: priA; TIGR00595
290317004381	ATP binding site [chemical binding]; other site
290317004382	putative Mg++ binding site [ion binding]; other site
290317004383	helicase superfamily c-terminal domain; Region: HELICc; smart00490
290317004384	ATP-binding site [chemical binding]; other site
290317004385	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
290317004386	Dehydroquinase class II; Region: DHquinase_II; pfam01220
290317004387	trimer interface [polypeptide binding]; other site
290317004388	active site
290317004389	dimer interface [polypeptide binding]; other site
290317004390	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
290317004391	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
290317004392	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317004393	Walker A motif; other site
290317004394	ATP binding site [chemical binding]; other site
290317004395	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317004396	Walker B motif; other site
290317004397	arginine finger; other site
290317004398	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
290317004399	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
290317004400	active site
290317004401	HslU subunit interaction site [polypeptide binding]; other site
290317004402	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
290317004403	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
290317004404	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
290317004405	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
290317004406	Protein of unknown function (DUF3109); Region: DUF3109; pfam11307
290317004407	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
290317004408	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
290317004409	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290317004410	putative active site [active]
290317004411	heme pocket [chemical binding]; other site
290317004412	GAF domain; Region: GAF; cl17456
290317004413	GAF domain; Region: GAF_2; pfam13185
290317004414	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290317004415	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290317004416	dimer interface [polypeptide binding]; other site
290317004417	phosphorylation site [posttranslational modification]
290317004418	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290317004419	ATP binding site [chemical binding]; other site
290317004420	Mg2+ binding site [ion binding]; other site
290317004421	G-X-G motif; other site
290317004422	Response regulator receiver domain; Region: Response_reg; pfam00072
290317004423	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290317004424	active site
290317004425	phosphorylation site [posttranslational modification]
290317004426	intermolecular recognition site; other site
290317004427	dimerization interface [polypeptide binding]; other site
290317004428	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
290317004429	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
290317004430	Protein of unknown function (DUF1318); Region: DUF1318; pfam07027
290317004431	Dicarboxylate transport; Region: DctA-YdbH; cl14674
290317004432	Dicarboxylate transport; Region: DctA-YdbH; cl14674
290317004433	Dicarboxylate transport; Region: DctA-YdbH; pfam11739
290317004434	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
290317004435	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
290317004436	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317004437	Walker A motif; other site
290317004438	ATP binding site [chemical binding]; other site
290317004439	Walker B motif; other site
290317004440	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
290317004441	Integrase core domain; Region: rve; pfam00665
290317004442	DinB superfamily; Region: DinB_2; pfam12867
290317004443	flavoprotein, HI0933 family; Region: TIGR00275
290317004444	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
290317004445	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
290317004446	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
290317004447	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
290317004448	HlyD family secretion protein; Region: HlyD_3; pfam13437
290317004449	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
290317004450	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
290317004451	DNA binding site [nucleotide binding]
290317004452	active site
290317004453	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290317004454	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
290317004455	binding surface
290317004456	TPR motif; other site
290317004457	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290317004458	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290317004459	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317004460	binding surface
290317004461	TPR motif; other site
290317004462	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290317004463	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290317004464	Tetratricopeptide repeat; Region: TPR_10; pfam13374
290317004465	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290317004466	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317004467	binding surface
290317004468	TPR motif; other site
290317004469	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290317004470	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
290317004471	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
290317004472	FMN binding site [chemical binding]; other site
290317004473	active site
290317004474	substrate binding site [chemical binding]; other site
290317004475	catalytic residue [active]
290317004476	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
290317004477	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
290317004478	UbiA prenyltransferase family; Region: UbiA; pfam01040
290317004479	Rubredoxin [Energy production and conversion]; Region: COG1773
290317004480	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
290317004481	iron binding site [ion binding]; other site
290317004482	Rubredoxin; Region: Rubredoxin; pfam00301
290317004483	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
290317004484	iron binding site [ion binding]; other site
290317004485	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
290317004486	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
290317004487	active site
290317004488	FMN binding site [chemical binding]; other site
290317004489	substrate binding site [chemical binding]; other site
290317004490	3Fe-4S cluster binding site [ion binding]; other site
290317004491	Rubrerythrin [Energy production and conversion]; Region: COG1592
290317004492	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
290317004493	binuclear metal center [ion binding]; other site
290317004494	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
290317004495	iron binding site [ion binding]; other site
290317004496	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
290317004497	Peptidase family M50; Region: Peptidase_M50; pfam02163
290317004498	active site
290317004499	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
290317004500	putative substrate binding region [chemical binding]; other site
290317004501	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
290317004502	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
290317004503	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
290317004504	active site residue [active]
290317004505	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
290317004506	active site
290317004507	catalytic site [active]
290317004508	substrate binding site [chemical binding]; other site
290317004509	Protein of unknown function DUF89; Region: DUF89; pfam01937
290317004510	Helix-turn-helix domain; Region: HTH_38; pfam13936
290317004511	heat shock protein HtpX; Provisional; Region: PRK05457
290317004512	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
290317004513	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290317004514	S-adenosylmethionine binding site [chemical binding]; other site
290317004515	Patatin-like phospholipase; Region: Pat17_PNPLA8_PNPLA9_like1; cd07213
290317004516	active site
290317004517	nucleophile elbow; other site
290317004518	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; pfam09603
290317004519	Protein of unknown function (DUF796); Region: DUF796; cl01226
290317004520	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549
290317004521	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
290317004522	carboxyltransferase (CT) interaction site; other site
290317004523	biotinylation site [posttranslational modification]; other site
290317004524	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
290317004525	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
290317004526	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
290317004527	oxaloacetate decarboxylase; Provisional; Region: PRK12330
290317004528	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
290317004529	active site
290317004530	metal binding site [ion binding]; metal-binding site
290317004531	homodimer binding site [polypeptide binding]; other site
290317004532	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
290317004533	PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750
290317004534	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
290317004535	GTPase RsgA; Reviewed; Region: PRK01889
290317004536	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
290317004537	GTPase/Zn-binding domain interface [polypeptide binding]; other site
290317004538	GTP/Mg2+ binding site [chemical binding]; other site
290317004539	G4 box; other site
290317004540	G5 box; other site
290317004541	G1 box; other site
290317004542	Switch I region; other site
290317004543	G2 box; other site
290317004544	G3 box; other site
290317004545	Switch II region; other site
290317004546	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
290317004547	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
290317004548	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
290317004549	Coenzyme A binding pocket [chemical binding]; other site
290317004550	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
290317004551	Phage terminase large subunit; Region: Terminase_3; cl12054
290317004552	Terminase-like family; Region: Terminase_6; pfam03237
290317004553	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
290317004554	N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178
290317004555	PLD-like domain; Region: PLDc_2; pfam13091
290317004556	putative homodimer interface [polypeptide binding]; other site
290317004557	putative active site [active]
290317004558	catalytic site [active]
290317004559	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290317004560	ATP binding site [chemical binding]; other site
290317004561	putative Mg++ binding site [ion binding]; other site
290317004562	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
290317004563	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
290317004564	nucleotide binding region [chemical binding]; other site
290317004565	ATP-binding site [chemical binding]; other site
290317004566	Methyltransferase domain; Region: Methyltransf_26; pfam13659
290317004567	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
290317004568	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
290317004569	PemK-like protein; Region: PemK; pfam02452
290317004570	Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201
290317004571	P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651
290317004572	Restriction endonuclease; Region: Mrr_cat; pfam04471
290317004573	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
290317004574	Mrr N-terminal domain; Region: Mrr_N; pfam14338
290317004575	Restriction endonuclease; Region: Mrr_cat; pfam04471
290317004576	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035
290317004577	putative uracil binding site [chemical binding]; other site
290317004578	putative active site [active]
290317004579	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
290317004580	MPN+ (JAMM) motif; other site
290317004581	Zinc-binding site [ion binding]; other site
290317004582	Helix-turn-helix domain; Region: HTH_19; pfam12844
290317004583	Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362
290317004584	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
290317004585	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
290317004586	integrase; Provisional; Region: PRK09692
290317004587	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
290317004588	active site
290317004589	Int/Topo IB signature motif; other site
290317004590	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
290317004591	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
290317004592	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
290317004593	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
290317004594	active site
290317004595	magnesium chelatase, H subunit; Region: BchH; TIGR02025
290317004596	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
290317004597	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
290317004598	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
290317004599	magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031
290317004600	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
290317004601	metal ion-dependent adhesion site (MIDAS); other site
290317004602	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
290317004603	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
290317004604	Walker A motif; other site
290317004605	ATP binding site [chemical binding]; other site
290317004606	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
290317004607	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
290317004608	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
290317004609	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
290317004610	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
290317004611	RNA binding surface [nucleotide binding]; other site
290317004612	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
290317004613	active site
290317004614	SET domain; Region: SET; pfam00856
290317004615	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
290317004616	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290317004617	NAD(P) binding site [chemical binding]; other site
290317004618	active site
290317004619	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
290317004620	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
290317004621	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
290317004622	thymidylate kinase; Validated; Region: tmk; PRK00698
290317004623	TMP-binding site; other site
290317004624	ATP-binding site [chemical binding]; other site
290317004625	phosphoglycolate phosphatase; Provisional; Region: PRK01158
290317004626	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
290317004627	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
290317004628	motif II; other site
290317004629	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
290317004630	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
290317004631	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
290317004632	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
290317004633	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
290317004634	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
290317004635	substrate binding site; other site
290317004636	dimer interface; other site
290317004637	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
290317004638	CoenzymeA binding site [chemical binding]; other site
290317004639	subunit interaction site [polypeptide binding]; other site
290317004640	PHB binding site; other site
290317004641	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
290317004642	B12 binding site [chemical binding]; other site
290317004643	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
290317004644	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290317004645	FeS/SAM binding site; other site
290317004646	Integrase core domain; Region: rve; pfam00665
290317004647	DDE domain; Region: DDE_Tnp_IS240; pfam13610
290317004648	Integrase core domain; Region: rve_3; pfam13683
290317004649	Transposase; Region: HTH_Tnp_1; cl17663
290317004650	PemK-like protein; Region: PemK; pfam02452
290317004651	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
290317004652	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
290317004653	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
290317004654	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
290317004655	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
290317004656	dimer interface [polypeptide binding]; other site
290317004657	anticodon binding site; other site
290317004658	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
290317004659	homodimer interface [polypeptide binding]; other site
290317004660	motif 1; other site
290317004661	active site
290317004662	motif 2; other site
290317004663	GAD domain; Region: GAD; pfam02938
290317004664	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
290317004665	active site
290317004666	motif 3; other site
290317004667	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14954
290317004668	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14955
290317004669	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317004670	Walker A motif; other site
290317004671	ATP binding site [chemical binding]; other site
290317004672	Walker B motif; other site
290317004673	arginine finger; other site
290317004674	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
290317004675	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
290317004676	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
290317004677	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290317004678	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
290317004679	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
290317004680	putative active site [active]
290317004681	catalytic triad [active]
290317004682	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
290317004683	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
290317004684	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
290317004685	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
290317004686	oligomerization interface [polypeptide binding]; other site
290317004687	active site
290317004688	metal binding site [ion binding]; metal-binding site
290317004689	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
290317004690	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
290317004691	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
290317004692	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
290317004693	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
290317004694	TPR repeat; Region: TPR_11; pfam13414
290317004695	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
290317004696	Transposase; Region: DDE_Tnp_ISL3; pfam01610
290317004697	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
290317004698	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
290317004699	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
290317004700	HlyD family secretion protein; Region: HlyD_3; pfam13437
290317004701	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
290317004702	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
290317004703	Walker A/P-loop; other site
290317004704	ATP binding site [chemical binding]; other site
290317004705	Q-loop/lid; other site
290317004706	ABC transporter signature motif; other site
290317004707	Walker B; other site
290317004708	D-loop; other site
290317004709	H-loop/switch region; other site
290317004710	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
290317004711	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
290317004712	FtsX-like permease family; Region: FtsX; pfam02687
290317004713	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
290317004714	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
290317004715	FtsX-like permease family; Region: FtsX; pfam02687
290317004716	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
290317004717	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
290317004718	ligand binding site [chemical binding]; other site
290317004719	SnoaL-like domain; Region: SnoaL_3; pfam13474
290317004720	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
290317004721	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
290317004722	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
290317004723	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
290317004724	trimer interface [polypeptide binding]; other site
290317004725	active site
290317004726	UDP-GlcNAc binding site [chemical binding]; other site
290317004727	lipid binding site [chemical binding]; lipid-binding site
290317004728	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
290317004729	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
290317004730	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
290317004731	active site
290317004732	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
290317004733	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
290317004734	5S rRNA interface [nucleotide binding]; other site
290317004735	CTC domain interface [polypeptide binding]; other site
290317004736	L16 interface [polypeptide binding]; other site
290317004737	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
290317004738	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
290317004739	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
290317004740	dimer interface [polypeptide binding]; other site
290317004741	conserved gate region; other site
290317004742	putative PBP binding loops; other site
290317004743	ABC-ATPase subunit interface; other site
290317004744	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
290317004745	dimer interface [polypeptide binding]; other site
290317004746	ADP-ribose binding site [chemical binding]; other site
290317004747	active site
290317004748	nudix motif; other site
290317004749	metal binding site [ion binding]; metal-binding site
290317004750	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
290317004751	NADH(P)-binding; Region: NAD_binding_10; pfam13460
290317004752	NAD(P) binding site [chemical binding]; other site
290317004753	putative active site [active]
290317004754	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
290317004755	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
290317004756	metal binding site [ion binding]; metal-binding site
290317004757	dimer interface [polypeptide binding]; other site
290317004758	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
290317004759	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335
290317004760	putative ligand binding site [chemical binding]; other site
290317004761	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
290317004762	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
290317004763	TM-ABC transporter signature motif; other site
290317004764	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
290317004765	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
290317004766	TM-ABC transporter signature motif; other site
290317004767	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
290317004768	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
290317004769	Walker A/P-loop; other site
290317004770	ATP binding site [chemical binding]; other site
290317004771	Q-loop/lid; other site
290317004772	ABC transporter signature motif; other site
290317004773	Walker B; other site
290317004774	D-loop; other site
290317004775	H-loop/switch region; other site
290317004776	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
290317004777	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
290317004778	Walker A/P-loop; other site
290317004779	ATP binding site [chemical binding]; other site
290317004780	Q-loop/lid; other site
290317004781	ABC transporter signature motif; other site
290317004782	Walker B; other site
290317004783	D-loop; other site
290317004784	H-loop/switch region; other site
290317004785	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
290317004786	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
290317004787	inhibitor binding site; inhibition site
290317004788	catalytic motif [active]
290317004789	Catalytic residue [active]
290317004790	Active site flap [active]
290317004791	prenyltransferase; Reviewed; Region: ubiA; PRK12884
290317004792	UbiA prenyltransferase family; Region: UbiA; pfam01040
290317004793	Protein of unknown function (DUF4019); Region: DUF4019; pfam13211
290317004794	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
290317004795	putative transposase OrfB; Reviewed; Region: PHA02517
290317004796	Homeodomain-like domain; Region: HTH_32; pfam13565
290317004797	Integrase core domain; Region: rve; pfam00665
290317004798	Integrase core domain; Region: rve_3; pfam13683
290317004799	Transposase; Region: HTH_Tnp_1; pfam01527
290317004800	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
290317004801	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
290317004802	sequence-specific DNA binding site [nucleotide binding]; other site
290317004803	salt bridge; other site
290317004804	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290317004805	Walker A/P-loop; other site
290317004806	ATP binding site [chemical binding]; other site
290317004807	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
290317004808	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
290317004809	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
290317004810	putative active site [active]
290317004811	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
290317004812	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290317004813	ATP binding site [chemical binding]; other site
290317004814	putative Mg++ binding site [ion binding]; other site
290317004815	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
290317004816	Divergent AAA domain; Region: AAA_4; pfam04326
290317004817	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
290317004818	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
290317004819	active site
290317004820	catalytic triad [active]
290317004821	dimer interface [polypeptide binding]; other site
290317004822	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
290317004823	putative active site [active]
290317004824	putative NTP binding site [chemical binding]; other site
290317004825	putative nucleic acid binding site [nucleotide binding]; other site
290317004826	DNA primase, catalytic core; Region: dnaG; TIGR01391
290317004827	CHC2 zinc finger; Region: zf-CHC2; cl17510
290317004828	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188
290317004829	active site
290317004830	metal binding site [ion binding]; metal-binding site
290317004831	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
290317004832	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
290317004833	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
290317004834	DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525
290317004835	BRO family, N-terminal domain; Region: Bro-N; pfam02498
290317004836	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
290317004837	HsdM N-terminal domain; Region: HsdM_N; pfam12161
290317004838	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290317004839	S-adenosylmethionine binding site [chemical binding]; other site
290317004840	Domain of unknown function DUF1828; Region: DUF1828; pfam08861
290317004841	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
290317004842	ADP-ribose binding site [chemical binding]; other site
290317004843	Curli production assembly/transport component CsgG; Region: CsgG; pfam03783
290317004844	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
290317004845	catalytic residues [active]
290317004846	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
290317004847	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
290317004848	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
290317004849	Competence protein; Region: Competence; pfam03772
290317004850	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
290317004851	FAD binding site [chemical binding]; other site
290317004852	diaminopimelate decarboxylase; Region: lysA; TIGR01048
290317004853	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
290317004854	active site
290317004855	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
290317004856	substrate binding site [chemical binding]; other site
290317004857	catalytic residues [active]
290317004858	dimer interface [polypeptide binding]; other site
290317004859	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
290317004860	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
290317004861	Putative zinc ribbon domain; Region: DUF164; pfam02591
290317004862	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
290317004863	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
290317004864	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
290317004865	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290317004866	homodimer interface [polypeptide binding]; other site
290317004867	catalytic residue [active]
290317004868	Protein of unknown function (DUF1353); Region: DUF1353; pfam07087
290317004869	Protein of unknown function (DUF456); Region: DUF456; pfam04306
290317004870	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
290317004871	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
290317004872	catalytic loop [active]
290317004873	iron binding site [ion binding]; other site
290317004874	Domain of unknown function (DUF4332); Region: DUF4332; pfam14229
290317004875	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
290317004876	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
290317004877	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
290317004878	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
290317004879	HflX GTPase family; Region: HflX; cd01878
290317004880	G1 box; other site
290317004881	GTP/Mg2+ binding site [chemical binding]; other site
290317004882	Switch I region; other site
290317004883	G2 box; other site
290317004884	G3 box; other site
290317004885	Switch II region; other site
290317004886	G4 box; other site
290317004887	G5 box; other site
290317004888	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
290317004889	active site lid residues [active]
290317004890	substrate binding pocket [chemical binding]; other site
290317004891	catalytic residues [active]
290317004892	substrate-Mg2+ binding site; other site
290317004893	aspartate-rich region 1; other site
290317004894	aspartate-rich region 2; other site
290317004895	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
290317004896	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
290317004897	dimer interface [polypeptide binding]; other site
290317004898	putative anticodon binding site; other site
290317004899	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
290317004900	motif 1; other site
290317004901	active site
290317004902	motif 2; other site
290317004903	motif 3; other site
290317004904	Divergent AAA domain; Region: AAA_4; pfam04326
290317004905	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
290317004906	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
290317004907	putative NAD(P) binding site [chemical binding]; other site
290317004908	active site
290317004909	putative substrate binding site [chemical binding]; other site
290317004910	Uncharacterized conserved protein [Function unknown]; Region: COG2308
290317004911	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
290317004912	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
290317004913	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
290317004914	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
290317004915	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
290317004916	Domain of unknown function (DUF4405); Region: DUF4405; pfam14358
290317004917	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
290317004918	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
290317004919	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
290317004920	HlyD family secretion protein; Region: HlyD_3; pfam13437
290317004921	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
290317004922	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
290317004923	Walker A/P-loop; other site
290317004924	ATP binding site [chemical binding]; other site
290317004925	Q-loop/lid; other site
290317004926	ABC transporter signature motif; other site
290317004927	Walker B; other site
290317004928	D-loop; other site
290317004929	H-loop/switch region; other site
290317004930	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
290317004931	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
290317004932	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
290317004933	Walker A/P-loop; other site
290317004934	ATP binding site [chemical binding]; other site
290317004935	Q-loop/lid; other site
290317004936	ABC transporter signature motif; other site
290317004937	Walker B; other site
290317004938	D-loop; other site
290317004939	H-loop/switch region; other site
290317004940	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
290317004941	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
290317004942	active site
290317004943	metal binding site [ion binding]; metal-binding site
290317004944	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
290317004945	Bacterial Ig-like domain; Region: Big_5; pfam13205
290317004946	cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059
290317004947	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
290317004948	active site
290317004949	metal binding site [ion binding]; metal-binding site
290317004950	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
290317004951	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
290317004952	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
290317004953	Cadherin repeat-like domain; Region: CA_like; cl15786
290317004954	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
290317004955	active site
290317004956	Cadherin repeat-like domain; Region: CA_like; cl15786
290317004957	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
290317004958	Ca2+ binding site [ion binding]; other site
290317004959	Bacterial Ig-like domain; Region: Big_5; pfam13205
290317004960	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
290317004961	Integrase core domain; Region: rve; pfam00665
290317004962	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
290317004963	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317004964	Walker A motif; other site
290317004965	ATP binding site [chemical binding]; other site
290317004966	Walker B motif; other site
290317004967	Domain of unknown function (DUF4402); Region: DUF4402; pfam14352
290317004968	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
290317004969	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
290317004970	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
290317004971	Domain of unknown function (DUF4402); Region: DUF4402; pfam14352
290317004972	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
290317004973	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
290317004974	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
290317004975	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
290317004976	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290317004977	FeS/SAM binding site; other site
290317004978	hypothetical protein; Reviewed; Region: PRK00024
290317004979	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
290317004980	MPN+ (JAMM) motif; other site
290317004981	Zinc-binding site [ion binding]; other site
290317004982	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
290317004983	DNA-binding site [nucleotide binding]; DNA binding site
290317004984	RNA-binding motif; other site
290317004985	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
290317004986	classical (c) SDRs; Region: SDR_c; cd05233
290317004987	NAD(P) binding site [chemical binding]; other site
290317004988	active site
290317004989	Yqey-like protein; Region: YqeY; pfam09424
290317004990	seryl-tRNA synthetase; Provisional; Region: PRK05431
290317004991	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
290317004992	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
290317004993	dimer interface [polypeptide binding]; other site
290317004994	active site
290317004995	motif 1; other site
290317004996	motif 2; other site
290317004997	motif 3; other site
290317004998	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
290317004999	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
290317005000	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
290317005001	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
290317005002	homodimer interface [polypeptide binding]; other site
290317005003	substrate-cofactor binding pocket; other site
290317005004	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290317005005	catalytic residue [active]
290317005006	16S rRNA methyltransferase B; Provisional; Region: PRK14904
290317005007	NusB family; Region: NusB; pfam01029
290317005008	putative RNA binding site [nucleotide binding]; other site
290317005009	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290317005010	S-adenosylmethionine binding site [chemical binding]; other site
290317005011	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
290317005012	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
290317005013	active site
290317005014	Int/Topo IB signature motif; other site
290317005015	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317005016	TPR motif; other site
290317005017	binding surface
290317005018	TPR repeat; Region: TPR_11; pfam13414
290317005019	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
290317005020	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
290317005021	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
290317005022	Beta-Casp domain; Region: Beta-Casp; smart01027
290317005023	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
290317005024	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
290317005025	putative metal binding site [ion binding]; other site
290317005026	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
290317005027	putative catalytic site [active]
290317005028	putative phosphate binding site [ion binding]; other site
290317005029	putative metal binding site [ion binding]; other site
290317005030	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
290317005031	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
290317005032	ATP binding site [chemical binding]; other site
290317005033	Mg++ binding site [ion binding]; other site
290317005034	motif III; other site
290317005035	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
290317005036	nucleotide binding region [chemical binding]; other site
290317005037	ATP-binding site [chemical binding]; other site
290317005038	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
290317005039	putative RNA binding site [nucleotide binding]; other site
290317005040	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
290317005041	potassium uptake protein; Region: kup; TIGR00794
290317005042	K+ potassium transporter; Region: K_trans; pfam02705
290317005043	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
290317005044	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
290317005045	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
290317005046	Domain of unknown function (DUF4293); Region: DUF4293; pfam14126
290317005047	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
290317005048	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
290317005049	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
290317005050	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290317005051	Walker A/P-loop; other site
290317005052	ATP binding site [chemical binding]; other site
290317005053	Q-loop/lid; other site
290317005054	ABC transporter signature motif; other site
290317005055	Walker B; other site
290317005056	D-loop; other site
290317005057	H-loop/switch region; other site
290317005058	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
290317005059	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
290317005060	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
290317005061	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
290317005062	active site
290317005063	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
290317005064	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
290317005065	TSCPD domain; Region: TSCPD; pfam12637
290317005066	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
290317005067	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290317005068	NAD(P) binding site [chemical binding]; other site
290317005069	active site
290317005070	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
290317005071	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
290317005072	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290317005073	putative active site [active]
290317005074	heme pocket [chemical binding]; other site
290317005075	Response regulator receiver domain; Region: Response_reg; pfam00072
290317005076	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290317005077	active site
290317005078	phosphorylation site [posttranslational modification]
290317005079	intermolecular recognition site; other site
290317005080	dimerization interface [polypeptide binding]; other site
290317005081	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290317005082	PAS fold; Region: PAS_3; pfam08447
290317005083	putative active site [active]
290317005084	heme pocket [chemical binding]; other site
290317005085	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290317005086	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
290317005087	putative active site [active]
290317005088	heme pocket [chemical binding]; other site
290317005089	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290317005090	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
290317005091	putative active site [active]
290317005092	heme pocket [chemical binding]; other site
290317005093	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290317005094	putative active site [active]
290317005095	heme pocket [chemical binding]; other site
290317005096	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290317005097	dimer interface [polypeptide binding]; other site
290317005098	phosphorylation site [posttranslational modification]
290317005099	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290317005100	ATP binding site [chemical binding]; other site
290317005101	Mg2+ binding site [ion binding]; other site
290317005102	G-X-G motif; other site
290317005103	Response regulator receiver domain; Region: Response_reg; pfam00072
290317005104	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290317005105	active site
290317005106	phosphorylation site [posttranslational modification]
290317005107	intermolecular recognition site; other site
290317005108	dimerization interface [polypeptide binding]; other site
290317005109	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
290317005110	CheB methylesterase; Region: CheB_methylest; pfam01339
290317005111	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
290317005112	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
290317005113	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290317005114	S-adenosylmethionine binding site [chemical binding]; other site
290317005115	Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473
290317005116	PAS domain; Region: PAS_10; pfam13596
290317005117	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290317005118	PAS domain; Region: PAS_9; pfam13426
290317005119	putative active site [active]
290317005120	heme pocket [chemical binding]; other site
290317005121	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
290317005122	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
290317005123	2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284
290317005124	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202
290317005125	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
290317005126	putative NAD(P) binding site [chemical binding]; other site
290317005127	chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016
290317005128	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
290317005129	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
290317005130	DNA binding residues [nucleotide binding]
290317005131	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
290317005132	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
290317005133	G1 box; other site
290317005134	putative GEF interaction site [polypeptide binding]; other site
290317005135	GTP/Mg2+ binding site [chemical binding]; other site
290317005136	Switch I region; other site
290317005137	G2 box; other site
290317005138	G3 box; other site
290317005139	Switch II region; other site
290317005140	G4 box; other site
290317005141	G5 box; other site
290317005142	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
290317005143	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
290317005144	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
290317005145	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
290317005146	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
290317005147	tRNA; other site
290317005148	putative tRNA binding site [nucleotide binding]; other site
290317005149	putative NADP binding site [chemical binding]; other site
290317005150	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
290317005151	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
290317005152	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
290317005153	domain interfaces; other site
290317005154	active site
290317005155	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
290317005156	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
290317005157	active site
290317005158	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
290317005159	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
290317005160	active site
290317005161	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290317005162	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290317005163	dimer interface [polypeptide binding]; other site
290317005164	phosphorylation site [posttranslational modification]
290317005165	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290317005166	ATP binding site [chemical binding]; other site
290317005167	Mg2+ binding site [ion binding]; other site
290317005168	G-X-G motif; other site
290317005169	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290317005170	active site
290317005171	phosphorylation site [posttranslational modification]
290317005172	intermolecular recognition site; other site
290317005173	Response regulator receiver domain; Region: Response_reg; pfam00072
290317005174	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290317005175	active site
290317005176	phosphorylation site [posttranslational modification]
290317005177	intermolecular recognition site; other site
290317005178	dimerization interface [polypeptide binding]; other site
290317005179	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
290317005180	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
290317005181	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
290317005182	A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756
290317005183	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
290317005184	dimer interface [polypeptide binding]; other site
290317005185	allosteric magnesium binding site [ion binding]; other site
290317005186	active site
290317005187	aspartate-rich active site metal binding site; other site
290317005188	Schiff base residues; other site
290317005189	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
290317005190	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
290317005191	Tetramer interface [polypeptide binding]; other site
290317005192	active site
290317005193	FMN-binding site [chemical binding]; other site
290317005194	serine acetyltransferase; Provisional; Region: cysE; PRK11132
290317005195	Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971
290317005196	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
290317005197	trimer interface [polypeptide binding]; other site
290317005198	active site
290317005199	substrate binding site [chemical binding]; other site
290317005200	CoA binding site [chemical binding]; other site
290317005201	ResB-like family; Region: ResB; pfam05140
290317005202	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
290317005203	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
290317005204	Zn2+ binding site [ion binding]; other site
290317005205	Mg2+ binding site [ion binding]; other site
290317005206	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
290317005207	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
290317005208	DXD motif; other site
290317005209	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
290317005210	putative ADP-binding pocket [chemical binding]; other site
290317005211	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290317005212	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
290317005213	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
290317005214	active site
290317005215	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290317005216	Radical SAM superfamily; Region: Radical_SAM; pfam04055
290317005217	FeS/SAM binding site; other site
290317005218	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
290317005219	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
290317005220	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
290317005221	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
290317005222	trimer interface [polypeptide binding]; other site
290317005223	active site
290317005224	substrate binding site [chemical binding]; other site
290317005225	CoA binding site [chemical binding]; other site
290317005226	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290317005227	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
290317005228	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
290317005229	AAA domain; Region: AAA_31; pfam13614
290317005230	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
290317005231	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
290317005232	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
290317005233	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
290317005234	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
290317005235	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
290317005236	Ligand binding site; other site
290317005237	metal-binding site
290317005238	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290317005239	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
290317005240	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
290317005241	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
290317005242	SLBB domain; Region: SLBB; pfam10531
290317005243	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
290317005244	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
290317005245	trimer interface [polypeptide binding]; other site
290317005246	active site
290317005247	substrate binding site [chemical binding]; other site
290317005248	CoA binding site [chemical binding]; other site
290317005249	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
290317005250	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
290317005251	active site
290317005252	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
290317005253	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
290317005254	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290317005255	ATP binding site [chemical binding]; other site
290317005256	Mg2+ binding site [ion binding]; other site
290317005257	G-X-G motif; other site
290317005258	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
290317005259	anti sigma factor interaction site; other site
290317005260	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
290317005261	regulatory phosphorylation site [posttranslational modification]; other site
290317005262	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
290317005263	active site
290317005264	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
290317005265	anti sigma factor interaction site; other site
290317005266	regulatory phosphorylation site [posttranslational modification]; other site
290317005267	Bacterial sugar transferase; Region: Bac_transf; pfam02397
290317005268	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
290317005269	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
290317005270	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
290317005271	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317005272	Walker A motif; other site
290317005273	ATP binding site [chemical binding]; other site
290317005274	Walker B motif; other site
290317005275	arginine finger; other site
290317005276	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290317005277	Response regulator receiver domain; Region: Response_reg; pfam00072
290317005278	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290317005279	active site
290317005280	phosphorylation site [posttranslational modification]
290317005281	intermolecular recognition site; other site
290317005282	dimerization interface [polypeptide binding]; other site
290317005283	PAS domain S-box; Region: sensory_box; TIGR00229
290317005284	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290317005285	putative active site [active]
290317005286	heme pocket [chemical binding]; other site
290317005287	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
290317005288	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
290317005289	Response regulator receiver domain; Region: Response_reg; pfam00072
290317005290	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290317005291	active site
290317005292	phosphorylation site [posttranslational modification]
290317005293	intermolecular recognition site; other site
290317005294	dimerization interface [polypeptide binding]; other site
290317005295	PAS domain; Region: PAS_9; pfam13426
290317005296	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290317005297	putative active site [active]
290317005298	heme pocket [chemical binding]; other site
290317005299	PAS domain S-box; Region: sensory_box; TIGR00229
290317005300	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290317005301	putative active site [active]
290317005302	heme pocket [chemical binding]; other site
290317005303	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290317005304	dimer interface [polypeptide binding]; other site
290317005305	phosphorylation site [posttranslational modification]
290317005306	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290317005307	ATP binding site [chemical binding]; other site
290317005308	G-X-G motif; other site
290317005309	Methyltransferase domain; Region: Methyltransf_31; pfam13847
290317005310	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290317005311	S-adenosylmethionine binding site [chemical binding]; other site
290317005312	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
290317005313	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
290317005314	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
290317005315	Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712
290317005316	Methyltransferase domain; Region: Methyltransf_23; pfam13489
290317005317	Methyltransferase domain; Region: Methyltransf_12; pfam08242
290317005318	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317005319	binding surface
290317005320	TPR motif; other site
290317005321	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
290317005322	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317005323	binding surface
290317005324	TPR motif; other site
290317005325	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317005326	binding surface
290317005327	TPR motif; other site
290317005328	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317005329	binding surface
290317005330	TPR motif; other site
290317005331	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
290317005332	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317005333	binding surface
290317005334	TPR repeat; Region: TPR_11; pfam13414
290317005335	TPR motif; other site
290317005336	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
290317005337	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317005338	binding surface
290317005339	TPR motif; other site
290317005340	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317005341	binding surface
290317005342	TPR motif; other site
290317005343	TPR repeat; Region: TPR_11; pfam13414
290317005344	TPR repeat; Region: TPR_11; pfam13414
290317005345	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317005346	binding surface
290317005347	TPR motif; other site
290317005348	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
290317005349	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317005350	binding surface
290317005351	TPR motif; other site
290317005352	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
290317005353	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317005354	binding surface
290317005355	TPR motif; other site
290317005356	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317005357	binding surface
290317005358	TPR repeat; Region: TPR_11; pfam13414
290317005359	TPR motif; other site
290317005360	TPR repeat; Region: TPR_11; pfam13414
290317005361	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317005362	binding surface
290317005363	TPR repeat; Region: TPR_11; pfam13414
290317005364	TPR motif; other site
290317005365	TPR repeat; Region: TPR_11; pfam13414
290317005366	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
290317005367	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317005368	binding surface
290317005369	TPR motif; other site
290317005370	TPR repeat; Region: TPR_11; pfam13414
290317005371	TPR repeat; Region: TPR_11; pfam13414
290317005372	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317005373	binding surface
290317005374	TPR motif; other site
290317005375	TPR repeat; Region: TPR_11; pfam13414
290317005376	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317005377	binding surface
290317005378	TPR motif; other site
290317005379	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
290317005380	Tetratricopeptide repeat; Region: TPR_16; pfam13432
290317005381	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317005382	binding surface
290317005383	TPR motif; other site
290317005384	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
290317005385	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317005386	binding surface
290317005387	TPR motif; other site
290317005388	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
290317005389	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317005390	binding surface
290317005391	TPR motif; other site
290317005392	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317005393	binding surface
290317005394	TPR motif; other site
290317005395	TPR repeat; Region: TPR_11; pfam13414
290317005396	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317005397	binding surface
290317005398	TPR motif; other site
290317005399	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
290317005400	Tetratricopeptide repeat; Region: TPR_1; pfam00515
290317005401	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317005402	binding surface
290317005403	TPR motif; other site
290317005404	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
290317005405	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317005406	binding surface
290317005407	TPR motif; other site
290317005408	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
290317005409	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317005410	binding surface
290317005411	TPR motif; other site
290317005412	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
290317005413	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317005414	binding surface
290317005415	TPR motif; other site
290317005416	Tetratricopeptide repeat; Region: TPR_16; pfam13432
290317005417	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317005418	binding surface
290317005419	TPR motif; other site
290317005420	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
290317005421	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317005422	binding surface
290317005423	TPR motif; other site
290317005424	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
290317005425	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317005426	binding surface
290317005427	TPR motif; other site
290317005428	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
290317005429	multidrug resistance protein MdtN; Provisional; Region: PRK10476
290317005430	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
290317005431	HlyD family secretion protein; Region: HlyD_3; pfam13437
290317005432	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
290317005433	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
290317005434	ligand binding site [chemical binding]; other site
290317005435	flexible hinge region; other site
290317005436	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
290317005437	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
290317005438	putative active site [active]
290317005439	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
290317005440	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290317005441	Walker A/P-loop; other site
290317005442	ATP binding site [chemical binding]; other site
290317005443	Q-loop/lid; other site
290317005444	ABC transporter signature motif; other site
290317005445	Walker B; other site
290317005446	D-loop; other site
290317005447	H-loop/switch region; other site
290317005448	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
290317005449	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
290317005450	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290317005451	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290317005452	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290317005453	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290317005454	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290317005455	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290317005456	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290317005457	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290317005458	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290317005459	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290317005460	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
290317005461	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
290317005462	active site
290317005463	Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731
290317005464	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290317005465	FeS/SAM binding site; other site
290317005466	PUCC protein; Region: PUCC; pfam03209
290317005467	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
290317005468	ThiC-associated domain; Region: ThiC-associated; pfam13667
290317005469	ThiC family; Region: ThiC; pfam01964
290317005470	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
290317005471	triosephosphate isomerase; Provisional; Region: PRK14565
290317005472	substrate binding site [chemical binding]; other site
290317005473	dimer interface [polypeptide binding]; other site
290317005474	catalytic triad [active]
290317005475	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
290317005476	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
290317005477	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
290317005478	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
290317005479	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
290317005480	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
290317005481	protein binding site [polypeptide binding]; other site
290317005482	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
290317005483	protein binding site [polypeptide binding]; other site
290317005484	anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
290317005485	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
290317005486	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
290317005487	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
290317005488	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
290317005489	Catalytic site [active]
290317005490	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
290317005491	GTP-binding protein LepA; Provisional; Region: PRK05433
290317005492	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
290317005493	G1 box; other site
290317005494	putative GEF interaction site [polypeptide binding]; other site
290317005495	GTP/Mg2+ binding site [chemical binding]; other site
290317005496	Switch I region; other site
290317005497	G2 box; other site
290317005498	G3 box; other site
290317005499	Switch II region; other site
290317005500	G4 box; other site
290317005501	G5 box; other site
290317005502	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
290317005503	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
290317005504	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
290317005505	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
290317005506	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
290317005507	putative active site [active]
290317005508	substrate binding site [chemical binding]; other site
290317005509	putative cosubstrate binding site; other site
290317005510	catalytic site [active]
290317005511	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
290317005512	substrate binding site [chemical binding]; other site
290317005513	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
290317005514	active site
290317005515	catalytic residues [active]
290317005516	metal binding site [ion binding]; metal-binding site
290317005517	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
290317005518	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
290317005519	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
290317005520	Ligand Binding Site [chemical binding]; other site
290317005521	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
290317005522	gamma-glutamyl kinase; Provisional; Region: PRK05429
290317005523	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
290317005524	nucleotide binding site [chemical binding]; other site
290317005525	homotetrameric interface [polypeptide binding]; other site
290317005526	putative phosphate binding site [ion binding]; other site
290317005527	putative allosteric binding site; other site
290317005528	PUA domain; Region: PUA; pfam01472
290317005529	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
290317005530	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
290317005531	putative catalytic cysteine [active]
290317005532	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
290317005533	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
290317005534	Walker A/P-loop; other site
290317005535	ATP binding site [chemical binding]; other site
290317005536	Q-loop/lid; other site
290317005537	ABC transporter signature motif; other site
290317005538	Walker B; other site
290317005539	D-loop; other site
290317005540	H-loop/switch region; other site
290317005541	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
290317005542	Major Facilitator Superfamily; Region: MFS_1; pfam07690
290317005543	putative substrate translocation pore; other site
290317005544	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
290317005545	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
290317005546	inhibitor-cofactor binding pocket; inhibition site
290317005547	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290317005548	catalytic residue [active]
290317005549	UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773
290317005550	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
290317005551	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
290317005552	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
290317005553	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
290317005554	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
290317005555	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
290317005556	Flavodoxin domain; Region: Flavodoxin_5; cl17428
290317005557	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
290317005558	chaperone protein DnaJ; Provisional; Region: PRK14281
290317005559	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
290317005560	HSP70 interaction site [polypeptide binding]; other site
290317005561	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
290317005562	substrate binding site [polypeptide binding]; other site
290317005563	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
290317005564	Zn binding sites [ion binding]; other site
290317005565	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
290317005566	dimer interface [polypeptide binding]; other site
290317005567	GrpE; Region: GrpE; pfam01025
290317005568	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
290317005569	dimer interface [polypeptide binding]; other site
290317005570	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
290317005571	heat shock gene repressor HrcA; Region: hrcA; TIGR00331
290317005572	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
290317005573	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290317005574	S-adenosylmethionine binding site [chemical binding]; other site
290317005575	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
290317005576	prolyl-tRNA synthetase; Provisional; Region: PRK08661
290317005577	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
290317005578	dimer interface [polypeptide binding]; other site
290317005579	motif 1; other site
290317005580	active site
290317005581	motif 2; other site
290317005582	motif 3; other site
290317005583	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
290317005584	anticodon binding site; other site
290317005585	zinc-binding site [ion binding]; other site
290317005586	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
290317005587	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
290317005588	dimer interface [polypeptide binding]; other site
290317005589	decamer (pentamer of dimers) interface [polypeptide binding]; other site
290317005590	catalytic triad [active]
290317005591	peroxidatic and resolving cysteines [active]
290317005592	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
290317005593	Predicted amidohydrolase [General function prediction only]; Region: COG0388
290317005594	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_8; cd07586
290317005595	putative active site [active]
290317005596	catalytic triad [active]
290317005597	putative dimer interface [polypeptide binding]; other site
290317005598	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14616
290317005599	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
290317005600	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
290317005601	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317005602	Walker A motif; other site
290317005603	ATP binding site [chemical binding]; other site
290317005604	Walker B motif; other site
290317005605	arginine finger; other site
290317005606	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290317005607	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
290317005608	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
290317005609	putative active site [active]
290317005610	catalytic triad [active]
290317005611	putative dimer interface [polypeptide binding]; other site
290317005612	Bacteriochlorophyll A protein; Region: BChl_A; pfam02327
290317005613	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
290317005614	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
290317005615	DNA binding residues [nucleotide binding]
290317005616	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
290317005617	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
290317005618	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290317005619	Walker A/P-loop; other site
290317005620	ATP binding site [chemical binding]; other site
290317005621	Q-loop/lid; other site
290317005622	ABC transporter signature motif; other site
290317005623	Walker B; other site
290317005624	D-loop; other site
290317005625	H-loop/switch region; other site
290317005626	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
290317005627	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290317005628	ATP-grasp domain; Region: ATP-grasp; pfam02222
290317005629	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
290317005630	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
290317005631	Tetratricopeptide repeat; Region: TPR_12; pfam13424
290317005632	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
290317005633	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
290317005634	putative active site [active]
290317005635	putative metal binding site [ion binding]; other site
290317005636	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
290317005637	NACHT domain; Region: NACHT; pfam05729
290317005638	Uncharacterized conserved protein [Function unknown]; Region: COG1262
290317005639	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
290317005640	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
290317005641	B12 binding site [chemical binding]; other site
290317005642	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
290317005643	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290317005644	FeS/SAM binding site; other site
290317005645	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
290317005646	MutS domain I; Region: MutS_I; pfam01624
290317005647	MutS domain II; Region: MutS_II; pfam05188
290317005648	MutS domain III; Region: MutS_III; pfam05192
290317005649	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
290317005650	Walker A/P-loop; other site
290317005651	ATP binding site [chemical binding]; other site
290317005652	Q-loop/lid; other site
290317005653	ABC transporter signature motif; other site
290317005654	Walker B; other site
290317005655	D-loop; other site
290317005656	H-loop/switch region; other site
290317005657	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
290317005658	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
290317005659	malate dehydrogenase; Reviewed; Region: PRK06223
290317005660	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
290317005661	NAD(P) binding site [chemical binding]; other site
290317005662	dimer interface [polypeptide binding]; other site
290317005663	tetramer (dimer of dimers) interface [polypeptide binding]; other site
290317005664	substrate binding site [chemical binding]; other site
290317005665	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
290317005666	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
290317005667	Peptidase family M48; Region: Peptidase_M48; pfam01435
290317005668	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
290317005669	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
290317005670	putative active site; other site
290317005671	catalytic triad [active]
290317005672	putative dimer interface [polypeptide binding]; other site
290317005673	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
290317005674	UbiA prenyltransferase family; Region: UbiA; pfam01040
290317005675	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
290317005676	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
290317005677	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
290317005678	4-aminobutyrate aminotransferase; Provisional; Region: PRK08360
290317005679	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
290317005680	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
290317005681	substrate binding site [chemical binding]; other site
290317005682	glutamase interaction surface [polypeptide binding]; other site
290317005683	Restriction endonuclease XhoI; Region: XhoI; pfam04555
290317005684	Methyltransferase domain; Region: Methyltransf_26; pfam13659
290317005685	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
290317005686	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547
290317005687	Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350
290317005688	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
290317005689	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
290317005690	oligomer interface [polypeptide binding]; other site
290317005691	metal binding site [ion binding]; metal-binding site
290317005692	metal binding site [ion binding]; metal-binding site
290317005693	Cl binding site [ion binding]; other site
290317005694	aspartate ring; other site
290317005695	basic sphincter; other site
290317005696	putative hydrophobic gate; other site
290317005697	periplasmic entrance; other site
290317005698	Radical SAM superfamily; Region: Radical_SAM; pfam04055
290317005699	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
290317005700	FeS/SAM binding site; other site
290317005701	Restriction endonuclease NotI; Region: NotI; pfam12183
290317005702	Restriction endonuclease NotI; Region: NotI; pfam12183
290317005703	Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230
290317005704	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
290317005705	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
290317005706	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
290317005707	active site
290317005708	purine riboside binding site [chemical binding]; other site
290317005709	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
290317005710	active site
290317005711	homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660
290317005712	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
290317005713	active site
290317005714	catalytic residues [active]
290317005715	metal binding site [ion binding]; metal-binding site
290317005716	Nif-specific regulatory protein; Region: nifA; TIGR01817
290317005717	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
290317005718	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317005719	Walker A motif; other site
290317005720	ATP binding site [chemical binding]; other site
290317005721	Walker B motif; other site
290317005722	arginine finger; other site
290317005723	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
290317005724	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
290317005725	active site
290317005726	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
290317005727	catalytic tetrad [active]
290317005728	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
290317005729	amphipathic channel; other site
290317005730	Asn-Pro-Ala signature motifs; other site
290317005731	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
290317005732	Integrase core domain; Region: rve; pfam00665
290317005733	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
290317005734	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317005735	Walker A motif; other site
290317005736	ATP binding site [chemical binding]; other site
290317005737	Walker B motif; other site
290317005738	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394
290317005739	NlpE N-terminal domain; Region: NlpE; pfam04170
290317005740	META domain; Region: META; pfam03724
290317005741	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
290317005742	active site
290317005743	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866
290317005744	putative hydrophobic ligand binding site [chemical binding]; other site
290317005745	cinnamyl-alcohol dehydrogenase family protein; Region: PLN02662
290317005746	flavonoid reductase (FR), extended (e) SDRs; Region: FR_SDR_e; cd08958
290317005747	NADP binding site [chemical binding]; other site
290317005748	substrate binding site [chemical binding]; other site
290317005749	active site
290317005750	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
290317005751	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
290317005752	Probable Catalytic site; other site
290317005753	metal-binding site
290317005754	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
290317005755	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
290317005756	substrate binding site [chemical binding]; other site
290317005757	active site
290317005758	catalytic residues [active]
290317005759	heterodimer interface [polypeptide binding]; other site
290317005760	CAAX protease self-immunity; Region: Abi; pfam02517
290317005761	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
290317005762	Ligand Binding Site [chemical binding]; other site
290317005763	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
290317005764	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
290317005765	ring oligomerisation interface [polypeptide binding]; other site
290317005766	ATP/Mg binding site [chemical binding]; other site
290317005767	stacking interactions; other site
290317005768	hinge regions; other site
290317005769	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
290317005770	oligomerisation interface [polypeptide binding]; other site
290317005771	mobile loop; other site
290317005772	roof hairpin; other site
290317005773	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
290317005774	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
290317005775	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290317005776	ABC transporter signature motif; other site
290317005777	Walker B; other site
290317005778	D-loop; other site
290317005779	H-loop/switch region; other site
290317005780	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
290317005781	Transcriptional regulator; Region: Rrf2; pfam02082
290317005782	Rrf2 family protein; Region: rrf2_super; TIGR00738
290317005783	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
290317005784	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
290317005785	catalytic site [active]
290317005786	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
290317005787	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
290317005788	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
290317005789	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290317005790	catalytic residue [active]
290317005791	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
290317005792	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
290317005793	Transposase; Region: DDE_Tnp_ISL3; pfam01610
290317005794	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
290317005795	non-specific DNA binding site [nucleotide binding]; other site
290317005796	salt bridge; other site
290317005797	sequence-specific DNA binding site [nucleotide binding]; other site
290317005798	Domain of unknown function (DUF955); Region: DUF955; pfam06114
290317005799	DEAD-like helicases superfamily; Region: DEXDc; smart00487
290317005800	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290317005801	ATP binding site [chemical binding]; other site
290317005802	putative Mg++ binding site [ion binding]; other site
290317005803	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
290317005804	nucleotide binding region [chemical binding]; other site
290317005805	ATP-binding site [chemical binding]; other site
290317005806	putative transposase OrfB; Reviewed; Region: PHA02517
290317005807	HTH-like domain; Region: HTH_21; pfam13276
290317005808	Integrase core domain; Region: rve; pfam00665
290317005809	Integrase core domain; Region: rve_3; pfam13683
290317005810	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
290317005811	Helix-turn-helix domain; Region: HTH_28; pfam13518
290317005812	hypothetical protein; Provisional; Region: PRK07179
290317005813	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
290317005814	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
290317005815	catalytic residue [active]
290317005816	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
290317005817	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290317005818	ATP binding site [chemical binding]; other site
290317005819	Mg2+ binding site [ion binding]; other site
290317005820	G-X-G motif; other site
290317005821	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
290317005822	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290317005823	active site
290317005824	phosphorylation site [posttranslational modification]
290317005825	intermolecular recognition site; other site
290317005826	dimerization interface [polypeptide binding]; other site
290317005827	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
290317005828	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290317005829	active site
290317005830	phosphorylation site [posttranslational modification]
290317005831	intermolecular recognition site; other site
290317005832	dimerization interface [polypeptide binding]; other site
290317005833	Hpt domain; Region: Hpt; pfam01627
290317005834	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
290317005835	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
290317005836	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
290317005837	catalytic triad [active]
290317005838	photolyase PhrII; Region: phr2; TIGR00591
290317005839	DNA photolyase; Region: DNA_photolyase; pfam00875
290317005840	ribonuclease R; Region: RNase_R; TIGR02063
290317005841	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
290317005842	RNB domain; Region: RNB; pfam00773
290317005843	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
290317005844	RNA binding site [nucleotide binding]; other site
290317005845	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
290317005846	metal binding site 2 [ion binding]; metal-binding site
290317005847	putative DNA binding helix; other site
290317005848	metal binding site 1 [ion binding]; metal-binding site
290317005849	dimer interface [polypeptide binding]; other site
290317005850	structural Zn2+ binding site [ion binding]; other site
290317005851	peroxiredoxin; Provisional; Region: PRK13189
290317005852	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
290317005853	dimer interface [polypeptide binding]; other site
290317005854	decamer (pentamer of dimers) interface [polypeptide binding]; other site
290317005855	catalytic triad [active]
290317005856	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
290317005857	dimer interface [polypeptide binding]; other site
290317005858	PYR/PP interface [polypeptide binding]; other site
290317005859	TPP binding site [chemical binding]; other site
290317005860	substrate binding site [chemical binding]; other site
290317005861	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
290317005862	TPP-binding site; other site
290317005863	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
290317005864	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
290317005865	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
290317005866	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
290317005867	acyl-activating enzyme (AAE) consensus motif; other site
290317005868	AMP binding site [chemical binding]; other site
290317005869	active site
290317005870	CoA binding site [chemical binding]; other site
290317005871	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
290317005872	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
290317005873	ACT domain-containing protein [General function prediction only]; Region: COG4747
290317005874	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
290317005875	C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882
290317005876	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
290317005877	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
290317005878	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290317005879	homodimer interface [polypeptide binding]; other site
290317005880	catalytic residue [active]
290317005881	N-acetyltransferase; Region: Acetyltransf_2; cl00949
290317005882	Protein of unknown function (DUF4019); Region: DUF4019; pfam13211
290317005883	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
290317005884	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
290317005885	active site
290317005886	FMN binding site [chemical binding]; other site
290317005887	substrate binding site [chemical binding]; other site
290317005888	putative catalytic residue [active]
290317005889	Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299
290317005890	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
290317005891	active site
290317005892	substrate binding site [chemical binding]; other site
290317005893	cosubstrate binding site; other site
290317005894	catalytic site [active]
290317005895	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
290317005896	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290317005897	FeS/SAM binding site; other site
290317005898	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
290317005899	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
290317005900	Ligand binding site; other site
290317005901	Putative Catalytic site; other site
290317005902	DXD motif; other site
290317005903	endonuclease IV; Provisional; Region: PRK01060
290317005904	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
290317005905	AP (apurinic/apyrimidinic) site pocket; other site
290317005906	DNA interaction; other site
290317005907	Metal-binding active site; metal-binding site
290317005908	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
290317005909	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
290317005910	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
290317005911	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
290317005912	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
290317005913	Protein of unknown function (DUF1847); Region: DUF1847; pfam08901
290317005914	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
290317005915	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
290317005916	active site
290317005917	tetramer interface [polypeptide binding]; other site
290317005918	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
290317005919	active site
290317005920	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
290317005921	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
290317005922	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
290317005923	active site
290317005924	HIGH motif; other site
290317005925	nucleotide binding site [chemical binding]; other site
290317005926	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
290317005927	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
290317005928	active site
290317005929	KMSKS motif; other site
290317005930	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
290317005931	tRNA binding surface [nucleotide binding]; other site
290317005932	anticodon binding site; other site
290317005933	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
290317005934	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
290317005935	NAD binding site [chemical binding]; other site
290317005936	homodimer interface [polypeptide binding]; other site
290317005937	active site
290317005938	substrate binding site [chemical binding]; other site
290317005939	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
290317005940	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
290317005941	NAD binding site [chemical binding]; other site
290317005942	substrate binding site [chemical binding]; other site
290317005943	homodimer interface [polypeptide binding]; other site
290317005944	active site
290317005945	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
290317005946	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
290317005947	NADP binding site [chemical binding]; other site
290317005948	active site
290317005949	putative substrate binding site [chemical binding]; other site
290317005950	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
290317005951	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
290317005952	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
290317005953	substrate binding site; other site
290317005954	tetramer interface; other site
290317005955	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
290317005956	classical (c) SDRs; Region: SDR_c; cd05233
290317005957	NAD(P) binding site [chemical binding]; other site
290317005958	active site
290317005959	Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850
290317005960	Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232
290317005961	dimer interface [polypeptide binding]; other site
290317005962	catalytic residue [active]
290317005963	metal binding site [ion binding]; metal-binding site
290317005964	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
290317005965	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
290317005966	putative active site; other site
290317005967	catalytic residue [active]
290317005968	short chain dehydrogenase; Validated; Region: PRK08324
290317005969	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
290317005970	active site
290317005971	Zn2+ binding site [ion binding]; other site
290317005972	intersubunit interface [polypeptide binding]; other site
290317005973	rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943
290317005974	putative NAD(P) binding site [chemical binding]; other site
290317005975	active site
290317005976	2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284
290317005977	RecX family; Region: RecX; pfam02631
290317005978	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
290317005979	putative nucleotide binding site [chemical binding]; other site
290317005980	uridine monophosphate binding site [chemical binding]; other site
290317005981	homohexameric interface [polypeptide binding]; other site
290317005982	elongation factor Ts; Provisional; Region: tsf; PRK09377
290317005983	UBA/TS-N domain; Region: UBA; pfam00627
290317005984	Elongation factor TS; Region: EF_TS; pfam00889
290317005985	Elongation factor TS; Region: EF_TS; pfam00889
290317005986	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
290317005987	rRNA interaction site [nucleotide binding]; other site
290317005988	S8 interaction site; other site
290317005989	putative laminin-1 binding site; other site
290317005990	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
290317005991	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
290317005992	23S rRNA interface [nucleotide binding]; other site
290317005993	L3 interface [polypeptide binding]; other site
290317005994	GTP-binding protein Der; Reviewed; Region: PRK00093
290317005995	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
290317005996	G1 box; other site
290317005997	GTP/Mg2+ binding site [chemical binding]; other site
290317005998	Switch I region; other site
290317005999	G2 box; other site
290317006000	Switch II region; other site
290317006001	G3 box; other site
290317006002	G4 box; other site
290317006003	G5 box; other site
290317006004	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
290317006005	G1 box; other site
290317006006	GTP/Mg2+ binding site [chemical binding]; other site
290317006007	Switch I region; other site
290317006008	G2 box; other site
290317006009	G3 box; other site
290317006010	Switch II region; other site
290317006011	G4 box; other site
290317006012	G5 box; other site
290317006013	antiporter inner membrane protein; Provisional; Region: PRK11670
290317006014	Domain of unknown function DUF59; Region: DUF59; pfam01883
290317006015	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
290317006016	Walker A motif; other site
290317006017	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
290317006018	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
290317006019	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
290317006020	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
290317006021	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
290317006022	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
290317006023	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
290317006024	Repair protein; Region: Repair_PSII; cl01535
290317006025	Repair protein; Region: Repair_PSII; pfam04536
290317006026	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
290317006027	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
290317006028	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
290317006029	Zn2+ binding site [ion binding]; other site
290317006030	Mg2+ binding site [ion binding]; other site
290317006031	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
290317006032	synthetase active site [active]
290317006033	NTP binding site [chemical binding]; other site
290317006034	metal binding site [ion binding]; metal-binding site
290317006035	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
290317006036	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
290317006037	excinuclease ABC subunit B; Provisional; Region: PRK05298
290317006038	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290317006039	ATP binding site [chemical binding]; other site
290317006040	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
290317006041	active site
290317006042	ATP binding site [chemical binding]; other site
290317006043	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
290317006044	putative Mg++ binding site [ion binding]; other site
290317006045	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
290317006046	nucleotide binding region [chemical binding]; other site
290317006047	ATP-binding site [chemical binding]; other site
290317006048	Ultra-violet resistance protein B; Region: UvrB; pfam12344
290317006049	UvrB/uvrC motif; Region: UVR; pfam02151
290317006050	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
290317006051	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
290317006052	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
290317006053	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
290317006054	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
290317006055	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
290317006056	Predicted permeases [General function prediction only]; Region: COG0795
290317006057	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
290317006058	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
290317006059	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
290317006060	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
290317006061	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
290317006062	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
290317006063	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
290317006064	DNA binding residues [nucleotide binding]
290317006065	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
290317006066	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
290317006067	active site
290317006068	HIGH motif; other site
290317006069	nucleotide binding site [chemical binding]; other site
290317006070	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
290317006071	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
290317006072	active site
290317006073	KMSKS motif; other site
290317006074	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
290317006075	tRNA binding surface [nucleotide binding]; other site
290317006076	anticodon binding site; other site
290317006077	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
290317006078	Clp protease; Region: CLP_protease; pfam00574
290317006079	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
290317006080	oligomer interface [polypeptide binding]; other site
290317006081	active site residues [active]
290317006082	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
290317006083	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
290317006084	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
290317006085	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
290317006086	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
290317006087	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
290317006088	active site
290317006089	nucleophile elbow; other site
290317006090	Surface antigen; Region: Bac_surface_Ag; pfam01103
290317006091	stationary phase survival protein SurE; Provisional; Region: PRK13932
290317006092	Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079
290317006093	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
290317006094	Predicted transcriptional regulator [General function prediction only]; Region: COG2522
290317006095	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
290317006096	sequence-specific DNA binding site [nucleotide binding]; other site
290317006097	salt bridge; other site
290317006098	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
290317006099	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
290317006100	glutamine binding [chemical binding]; other site
290317006101	catalytic triad [active]
290317006102	Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562
290317006103	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991
290317006104	Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635
290317006105	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
290317006106	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
290317006107	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
290317006108	Low molecular weight phosphatase family; Region: LMWPc; cd00115
290317006109	active site
290317006110	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
290317006111	Integrase core domain; Region: rve; pfam00665
290317006112	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
290317006113	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317006114	Walker A motif; other site
290317006115	ATP binding site [chemical binding]; other site
290317006116	Walker B motif; other site
290317006117	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
290317006118	CRISPR associated protein Cas6; Region: Cas_Cas6; pfam01881
290317006119	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817
290317006120	CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437
290317006121	CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437
290317006122	CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438
290317006123	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
290317006124	CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622
290317006125	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680
290317006126	CRISPR/Cas system-associated protein Csx15; Region: Csx15_I-U; cd09766
290317006127	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817
290317006128	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
290317006129	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
290317006130	putative active site [active]
290317006131	putative NTP binding site [chemical binding]; other site
290317006132	putative nucleic acid binding site [nucleotide binding]; other site
290317006133	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
290317006134	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
290317006135	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
290317006136	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
290317006137	synthetase active site [active]
290317006138	NTP binding site [chemical binding]; other site
290317006139	metal binding site [ion binding]; metal-binding site
290317006140	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359
290317006141	putative dimer interface [polypeptide binding]; other site
290317006142	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
290317006143	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
290317006144	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
290317006145	Uncharacterized conserved protein (DUF2276); Region: DUF2276; pfam10040
290317006146	Enterobacterial EspB protein; Region: EspB; pfam05802
290317006147	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
290317006148	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
290317006149	active site
290317006150	DNA binding site [nucleotide binding]
290317006151	Int/Topo IB signature motif; other site
290317006152	putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968
290317006153	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
290317006154	NAD(P) binding site [chemical binding]; other site
290317006155	catalytic residues [active]
290317006156	GTPase RsgA; Reviewed; Region: PRK00098
290317006157	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
290317006158	GTPase/Zn-binding domain interface [polypeptide binding]; other site
290317006159	GTP/Mg2+ binding site [chemical binding]; other site
290317006160	G4 box; other site
290317006161	G5 box; other site
290317006162	G1 box; other site
290317006163	Switch I region; other site
290317006164	G2 box; other site
290317006165	G3 box; other site
290317006166	Switch II region; other site
290317006167	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
290317006168	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
290317006169	generic binding surface II; other site
290317006170	ssDNA binding site; other site
290317006171	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290317006172	ATP binding site [chemical binding]; other site
290317006173	putative Mg++ binding site [ion binding]; other site
290317006174	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
290317006175	nucleotide binding region [chemical binding]; other site
290317006176	ATP-binding site [chemical binding]; other site
290317006177	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
290317006178	ribosome recycling factor; Reviewed; Region: frr; PRK00083
290317006179	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
290317006180	hinge region; other site
290317006181	Chlide_reductase_Y : Y subunit of chlorophyllide (chlide) reductase (BchY).  Chlide reductase participates in photosynthetic pigment synthesis playing a role in the conversion of chlorophylls(Chl) into bacteriochlorophylls (BChl). Chlide reductase...; Region: Chlide_reductase_Y; cd01980
290317006182	chlorophyllide reductase subunit Y; Region: BchY; TIGR02015
290317006183	Bacterial DNA-binding protein; Region: Bac_DNA_binding; pfam00216
290317006184	IHF dimer interface [polypeptide binding]; other site
290317006185	IHF - DNA interface [nucleotide binding]; other site
290317006186	Sporulation related domain; Region: SPOR; pfam05036
290317006187	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
290317006188	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
290317006189	generic binding surface II; other site
290317006190	generic binding surface I; other site
290317006191	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
290317006192	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
290317006193	Ligand binding site; other site
290317006194	oligomer interface; other site
290317006195	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
290317006196	putative active site [active]
290317006197	dimerization interface [polypeptide binding]; other site
290317006198	putative tRNAtyr binding site [nucleotide binding]; other site
290317006199	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
290317006200	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
290317006201	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
290317006202	Citrate synthase; Region: Citrate_synt; pfam00285
290317006203	oxalacetate binding site [chemical binding]; other site
290317006204	citrylCoA binding site [chemical binding]; other site
290317006205	coenzyme A binding site [chemical binding]; other site
290317006206	catalytic triad [active]
290317006207	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
290317006208	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
290317006209	ligand binding site [chemical binding]; other site
290317006210	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
290317006211	putative metal binding site [ion binding]; other site
290317006212	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
290317006213	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
290317006214	metal-binding site [ion binding]
290317006215	TPR repeat; Region: TPR_11; pfam13414
290317006216	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317006217	binding surface
290317006218	TPR motif; other site
290317006219	Tetratricopeptide repeat; Region: TPR_16; pfam13432
290317006220	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317006221	binding surface
290317006222	TPR motif; other site
290317006223	TPR repeat; Region: TPR_11; pfam13414
290317006224	chorismate binding enzyme; Region: Chorismate_bind; cl10555
290317006225	aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824
290317006226	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
290317006227	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
290317006228	dimer interface [polypeptide binding]; other site
290317006229	tetramer interface [polypeptide binding]; other site
290317006230	PYR/PP interface [polypeptide binding]; other site
290317006231	TPP binding site [chemical binding]; other site
290317006232	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
290317006233	TPP-binding site; other site
290317006234	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
290317006235	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
290317006236	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
290317006237	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
290317006238	substrate binding site [chemical binding]; other site
290317006239	oxyanion hole (OAH) forming residues; other site
290317006240	trimer interface [polypeptide binding]; other site
290317006241	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
290317006242	o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927
290317006243	active site
290317006244	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
290317006245	O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923
290317006246	acyl-activating enzyme (AAE) consensus motif; other site
290317006247	putative AMP binding site [chemical binding]; other site
290317006248	putative active site [active]
290317006249	putative CoA binding site [chemical binding]; other site
290317006250	dihydrodipicolinate reductase; Provisional; Region: PRK00048
290317006251	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
290317006252	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
290317006253	ParB-like nuclease domain; Region: ParB; smart00470
290317006254	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
290317006255	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
290317006256	KorB domain; Region: KorB; pfam08535
290317006257	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
290317006258	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
290317006259	P-loop; other site
290317006260	Magnesium ion binding site [ion binding]; other site
290317006261	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
290317006262	Magnesium ion binding site [ion binding]; other site
290317006263	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
290317006264	active site
290317006265	DNA binding site [nucleotide binding]
290317006266	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
290317006267	MgtE intracellular N domain; Region: MgtE_N; pfam03448
290317006268	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
290317006269	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
290317006270	Divalent cation transporter; Region: MgtE; pfam01769
290317006271	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
290317006272	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
290317006273	Ligand Binding Site [chemical binding]; other site
290317006274	Predicted esterase [General function prediction only]; Region: COG0400
290317006275	putative hydrolase; Provisional; Region: PRK11460
290317006276	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
290317006277	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
290317006278	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
290317006279	substrate binding pocket [chemical binding]; other site
290317006280	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
290317006281	B12 binding site [chemical binding]; other site
290317006282	cobalt ligand [ion binding]; other site
290317006283	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
290317006284	octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315
290317006285	Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783
290317006286	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
290317006287	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
290317006288	Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078
290317006289	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
290317006290	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
290317006291	ligand binding site [chemical binding]; other site
290317006292	AAA domain; Region: AAA_14; pfam13173
290317006293	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
290317006294	Methyltransferase domain; Region: Methyltransf_31; pfam13847
290317006295	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290317006296	S-adenosylmethionine binding site [chemical binding]; other site
290317006297	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
290317006298	Integrase core domain; Region: rve; pfam00665
290317006299	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
290317006300	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317006301	Walker A motif; other site
290317006302	ATP binding site [chemical binding]; other site
290317006303	Walker B motif; other site
290317006304	putative transposase OrfB; Reviewed; Region: PHA02517
290317006305	HTH-like domain; Region: HTH_21; pfam13276
290317006306	Integrase core domain; Region: rve; pfam00665
290317006307	Integrase core domain; Region: rve_3; pfam13683
290317006308	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
290317006309	Helix-turn-helix domain; Region: HTH_28; pfam13518
290317006310	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
290317006311	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
290317006312	AAA domain; Region: AAA_14; pfam13173
290317006313	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
290317006314	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
290317006315	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
290317006316	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
290317006317	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
290317006318	DsrE/DsrF-like family; Region: DrsE; cl00672
290317006319	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
290317006320	dimerization interface [polypeptide binding]; other site
290317006321	putative DNA binding site [nucleotide binding]; other site
290317006322	putative Zn2+ binding site [ion binding]; other site
290317006323	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
290317006324	active site residue [active]
290317006325	Methyltransferase domain; Region: Methyltransf_31; pfam13847
290317006326	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290317006327	S-adenosylmethionine binding site [chemical binding]; other site
290317006328	This putative domain contains a quite highly conserved sequence of CGGC in its central region; Region: CGGC; smart01078
290317006329	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
290317006330	putative metal binding site [ion binding]; other site
290317006331	putative homodimer interface [polypeptide binding]; other site
290317006332	putative homotetramer interface [polypeptide binding]; other site
290317006333	putative homodimer-homodimer interface [polypeptide binding]; other site
290317006334	putative allosteric switch controlling residues; other site
290317006335	Transposase IS200 like; Region: Y1_Tnp; cl00848
290317006336	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
290317006337	Winged helix-turn helix; Region: HTH_29; pfam13551
290317006338	Helix-turn-helix domain; Region: HTH_28; pfam13518
290317006339	Winged helix-turn helix; Region: HTH_33; pfam13592
290317006340	DDE superfamily endonuclease; Region: DDE_3; pfam13358
290317006341	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
290317006342	NB-ARC domain; Region: NB-ARC; pfam00931
290317006343	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
290317006344	MT-A70; Region: MT-A70; cl01947
290317006345	Restriction endonuclease BglII; Region: Endonuc-BglII; pfam09195
290317006346	Winged helix-turn helix; Region: HTH_29; pfam13551
290317006347	Helix-turn-helix domain; Region: HTH_28; pfam13518
290317006348	Winged helix-turn helix; Region: HTH_33; pfam13592
290317006349	DDE superfamily endonuclease; Region: DDE_3; pfam13358
290317006350	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
290317006351	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
290317006352	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
290317006353	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
290317006354	putative hydrophobic ligand binding site [chemical binding]; other site
290317006355	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
290317006356	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
290317006357	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
290317006358	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
290317006359	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
290317006360	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
290317006361	Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042
290317006362	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
290317006363	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
290317006364	TPP-binding site [chemical binding]; other site
290317006365	dimer interface [polypeptide binding]; other site
290317006366	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
290317006367	PYR/PP interface [polypeptide binding]; other site
290317006368	dimer interface [polypeptide binding]; other site
290317006369	TPP binding site [chemical binding]; other site
290317006370	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
290317006371	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
290317006372	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
290317006373	putative active site [active]
290317006374	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
290317006375	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
290317006376	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
290317006377	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
290317006378	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
290317006379	PAS domain; Region: PAS; smart00091
290317006380	PAS fold; Region: PAS_4; pfam08448
290317006381	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290317006382	dimer interface [polypeptide binding]; other site
290317006383	phosphorylation site [posttranslational modification]
290317006384	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290317006385	ATP binding site [chemical binding]; other site
290317006386	Mg2+ binding site [ion binding]; other site
290317006387	G-X-G motif; other site
290317006388	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
290317006389	active site
290317006390	phosphorylation site [posttranslational modification]
290317006391	intermolecular recognition site; other site
290317006392	dimerization interface [polypeptide binding]; other site
290317006393	Response regulator receiver domain; Region: Response_reg; pfam00072
290317006394	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290317006395	active site
290317006396	phosphorylation site [posttranslational modification]
290317006397	intermolecular recognition site; other site
290317006398	dimerization interface [polypeptide binding]; other site
290317006399	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
290317006400	Uncharacterized conserved protein [Function unknown]; Region: COG3287
290317006401	FIST N domain; Region: FIST; pfam08495
290317006402	FIST C domain; Region: FIST_C; pfam10442
290317006403	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859
290317006404	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290317006405	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
290317006406	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
290317006407	putative deacylase active site [active]
290317006408	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
290317006409	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
290317006410	nucleophile elbow; other site
290317006411	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
290317006412	ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087
290317006413	NAD(P) binding site [chemical binding]; other site
290317006414	catalytic residues [active]
290317006415	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
290317006416	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
290317006417	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
290317006418	Walker A/P-loop; other site
290317006419	ATP binding site [chemical binding]; other site
290317006420	Q-loop/lid; other site
290317006421	ABC transporter signature motif; other site
290317006422	Walker B; other site
290317006423	D-loop; other site
290317006424	H-loop/switch region; other site
290317006425	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
290317006426	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
290317006427	Ligand Binding Site [chemical binding]; other site
290317006428	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
290317006429	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
290317006430	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
290317006431	Peptidase family U32; Region: Peptidase_U32; pfam01136
290317006432	sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910
290317006433	cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345
290317006434	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
290317006435	FAD binding pocket [chemical binding]; other site
290317006436	FAD binding motif [chemical binding]; other site
290317006437	phosphate binding motif [ion binding]; other site
290317006438	beta-alpha-beta structure motif; other site
290317006439	NAD binding pocket [chemical binding]; other site
290317006440	Iron coordination center [ion binding]; other site
290317006441	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
290317006442	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
290317006443	four helix bundle suffix domain; Region: 4helix_suffix; TIGR04258
290317006444	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
290317006445	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317006446	Walker A motif; other site
290317006447	ATP binding site [chemical binding]; other site
290317006448	Walker B motif; other site
290317006449	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
290317006450	Integrase core domain; Region: rve; pfam00665
290317006451	putative addiction module antidote; Region: doc_partner; TIGR02609
290317006452	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
290317006453	Predicted ATPase [General function prediction only]; Region: COG4637
290317006454	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
290317006455	Walker A/P-loop; other site
290317006456	ATP binding site [chemical binding]; other site
290317006457	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
290317006458	Protein of unknown function (DUF3680); Region: DUF3680; pfam12441
290317006459	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
290317006460	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304
290317006461	Uncharacterized conserved protein [Function unknown]; Region: COG2442
290317006462	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
290317006463	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
290317006464	Virulence protein [General function prediction only]; Region: COG3943
290317006465	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
290317006466	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
290317006467	HicB family; Region: HicB; pfam05534
290317006468	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
290317006469	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
290317006470	Uncharacterized conserved protein [Function unknown]; Region: COG2442
290317006471	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
290317006472	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
290317006473	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
290317006474	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
290317006475	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
290317006476	TPR repeat; Region: TPR_11; pfam13414
290317006477	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317006478	binding surface
290317006479	TPR motif; other site
290317006480	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
290317006481	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317006482	binding surface
290317006483	TPR motif; other site
290317006484	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317006485	binding surface
290317006486	TPR motif; other site
290317006487	Transposase IS200 like; Region: Y1_Tnp; cl00848
290317006488	Transposase IS200 like; Region: Y1_Tnp; cl00848
290317006489	AAA domain; Region: AAA_21; pfam13304
290317006490	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
290317006491	RloB-like protein; Region: RloB; pfam13707
290317006492	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
290317006493	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317006494	Walker A motif; other site
290317006495	ATP binding site [chemical binding]; other site
290317006496	Walker B motif; other site
290317006497	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
290317006498	Integrase core domain; Region: rve; pfam00665
290317006499	Transposase IS200 like; Region: Y1_Tnp; cl00848
290317006500	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
290317006501	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
290317006502	putative active site [active]
290317006503	putative NTP binding site [chemical binding]; other site
290317006504	putative nucleic acid binding site [nucleotide binding]; other site
290317006505	Transposase IS200 like; Region: Y1_Tnp; cl00848
290317006506	Helix-turn-helix domain; Region: HTH_28; pfam13518
290317006507	Homeodomain-like domain; Region: HTH_32; pfam13565
290317006508	Integrase core domain; Region: rve; pfam00665
290317006509	Integrase core domain; Region: rve_3; pfam13683
290317006510	Uncharacterized conserved protein [Function unknown]; Region: COG2442
290317006511	Winged helix-turn helix; Region: HTH_29; pfam13551
290317006512	Homeodomain-like domain; Region: HTH_32; pfam13565
290317006513	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
290317006514	Transposase; Region: DEDD_Tnp_IS110; pfam01548
290317006515	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
290317006516	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
290317006517	DEAD-like helicases superfamily; Region: DEXDc; smart00487
290317006518	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
290317006519	ATP binding site [chemical binding]; other site
290317006520	putative Mg++ binding site [ion binding]; other site
290317006521	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
290317006522	nucleotide binding region [chemical binding]; other site
290317006523	ATP-binding site [chemical binding]; other site
290317006524	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
290317006525	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
290317006526	Transposase IS200 like; Region: Y1_Tnp; cl00848
290317006527	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035
290317006528	putative uracil binding site [chemical binding]; other site
290317006529	putative active site [active]
290317006530	Transposase IS200 like; Region: Y1_Tnp; cl00848
290317006531	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
290317006532	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317006533	Walker A motif; other site
290317006534	ATP binding site [chemical binding]; other site
290317006535	Walker B motif; other site
290317006536	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
290317006537	Integrase core domain; Region: rve; pfam00665
290317006538	Homeodomain-like domain; Region: HTH_23; pfam13384
290317006539	Winged helix-turn helix; Region: HTH_29; pfam13551
290317006540	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
290317006541	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
290317006542	Transposase IS200 like; Region: Y1_Tnp; cl00848
290317006543	Transposase IS200 like; Region: Y1_Tnp; cl00848
290317006544	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
290317006545	RES domain; Region: RES; smart00953
290317006546	Beta protein; Region: Beta_protein; pfam14350
290317006547	Uncharacterized conserved protein [Function unknown]; Region: COG1262
290317006548	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
290317006549	Ycf46; Provisional; Region: ycf46; CHL00195
290317006550	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317006551	Walker A motif; other site
290317006552	ATP binding site [chemical binding]; other site
290317006553	Walker B motif; other site
290317006554	arginine finger; other site
290317006555	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
290317006556	nucleotide binding site [chemical binding]; other site
290317006557	putative NEF/HSP70 interaction site [polypeptide binding]; other site
290317006558	SBD interface [polypeptide binding]; other site
290317006559	Sulfatase; Region: Sulfatase; cl17466
290317006560	HipA N-terminal domain; Region: Couple_hipA; pfam13657
290317006561	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
290317006562	HipA-like N-terminal domain; Region: HipA_N; pfam07805
290317006563	HipA-like C-terminal domain; Region: HipA_C; pfam07804
290317006564	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290317006565	NAD(P) binding site [chemical binding]; other site
290317006566	active site
290317006567	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
290317006568	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
290317006569	Mechanosensitive ion channel; Region: MS_channel; pfam00924
290317006570	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
290317006571	protoporphyrinogen oxidase; Region: proto_IX_ox; TIGR00562
290317006572	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
290317006573	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
290317006574	Transposase; Region: DDE_Tnp_ISL3; pfam01610
290317006575	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
290317006576	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
290317006577	trimer interface [polypeptide binding]; other site
290317006578	putative metal binding site [ion binding]; other site
290317006579	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
290317006580	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
290317006581	Walker A/P-loop; other site
290317006582	ATP binding site [chemical binding]; other site
290317006583	Q-loop/lid; other site
290317006584	ABC transporter signature motif; other site
290317006585	Walker B; other site
290317006586	D-loop; other site
290317006587	H-loop/switch region; other site
290317006588	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
290317006589	B12 binding domain; Region: B12-binding; pfam02310
290317006590	B12 binding site [chemical binding]; other site
290317006591	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290317006592	FeS/SAM binding site; other site
290317006593	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
290317006594	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
290317006595	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
290317006596	Zn2+ binding site [ion binding]; other site
290317006597	Mg2+ binding site [ion binding]; other site
290317006598	YtxH-like protein; Region: YtxH; pfam12732
290317006599	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
290317006600	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
290317006601	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
290317006602	hinge; other site
290317006603	active site
290317006604	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
290317006605	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
290317006606	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
290317006607	dimer interface [polypeptide binding]; other site
290317006608	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290317006609	catalytic residue [active]
290317006610	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
290317006611	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
290317006612	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
290317006613	alanine racemase; Reviewed; Region: alr; PRK00053
290317006614	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
290317006615	active site
290317006616	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
290317006617	dimer interface [polypeptide binding]; other site
290317006618	substrate binding site [chemical binding]; other site
290317006619	catalytic residues [active]
290317006620	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
290317006621	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
290317006622	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
290317006623	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
290317006624	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
290317006625	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
290317006626	FMN binding site [chemical binding]; other site
290317006627	active site
290317006628	catalytic residues [active]
290317006629	substrate binding site [chemical binding]; other site
290317006630	recombinase A; Provisional; Region: recA; PRK09354
290317006631	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
290317006632	hexamer interface [polypeptide binding]; other site
290317006633	Walker A motif; other site
290317006634	ATP binding site [chemical binding]; other site
290317006635	Walker B motif; other site
290317006636	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
290317006637	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
290317006638	putative NADP binding site [chemical binding]; other site
290317006639	putative substrate binding site [chemical binding]; other site
290317006640	active site
290317006641	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
290317006642	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
290317006643	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
290317006644	trigger factor; Region: tig; TIGR00115
290317006645	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
290317006646	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
290317006647	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
290317006648	dimerization interface [polypeptide binding]; other site
290317006649	active site
290317006650	Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539
290317006651	active site
290317006652	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
290317006653	catalytic center binding site [active]
290317006654	ATP binding site [chemical binding]; other site
290317006655	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
290317006656	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
290317006657	P loop; other site
290317006658	Nucleotide binding site [chemical binding]; other site
290317006659	DTAP/Switch II; other site
290317006660	Switch I; other site
290317006661	Bacteriochlorophyll C binding protein; Region: Bac_chlorC; pfam02043
290317006662	Chlorosome envelope protein C; Region: Chlorosome_CsmC; pfam11098
290317006663	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
290317006664	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
290317006665	P loop; other site
290317006666	Nucleotide binding site [chemical binding]; other site
290317006667	DTAP/Switch II; other site
290317006668	Switch I; other site
290317006669	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
290317006670	2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
290317006671	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
290317006672	FAD binding pocket [chemical binding]; other site
290317006673	FAD binding motif [chemical binding]; other site
290317006674	phosphate binding motif [ion binding]; other site
290317006675	beta-alpha-beta structure motif; other site
290317006676	NAD binding pocket [chemical binding]; other site
290317006677	Iron coordination center [ion binding]; other site
290317006678	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
290317006679	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
290317006680	dimer interface [polypeptide binding]; other site
290317006681	ssDNA binding site [nucleotide binding]; other site
290317006682	tetramer (dimer of dimers) interface [polypeptide binding]; other site
290317006683	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
290317006684	DNA polymerase III, delta subunit; Region: holA; TIGR01128
290317006685	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
290317006686	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290317006687	NAD(P) binding site [chemical binding]; other site
290317006688	active site
290317006689	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
290317006690	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
290317006691	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
290317006692	catalytic residue [active]
290317006693	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
290317006694	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317006695	Walker A motif; other site
290317006696	ATP binding site [chemical binding]; other site
290317006697	Walker B motif; other site
290317006698	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
290317006699	Integrase core domain; Region: rve; pfam00665
290317006700	Cna protein B-type domain; Region: Cna_B_2; pfam13715
290317006701	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
290317006702	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
290317006703	N-terminal plug; other site
290317006704	ligand-binding site [chemical binding]; other site
290317006705	magnesium chelatase, H subunit; Region: BchH; TIGR02025
290317006706	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
290317006707	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
290317006708	magnesium chelatase subunit H; Provisional; Region: PRK12493
290317006709	Domain of unknown function (DUF3479); Region: DUF3479; pfam11965
290317006710	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
290317006711	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
290317006712	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
290317006713	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290317006714	S-adenosylmethionine binding site [chemical binding]; other site
290317006715	Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109
290317006716	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026
290317006717	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
290317006718	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290317006719	FeS/SAM binding site; other site
290317006720	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
290317006721	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
290317006722	putative dimer interface [polypeptide binding]; other site
290317006723	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
290317006724	GIY-YIG motif/motif A; other site
290317006725	putative active site [active]
290317006726	putative metal binding site [ion binding]; other site
290317006727	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290317006728	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
290317006729	putative ADP-binding pocket [chemical binding]; other site
290317006730	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
290317006731	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
290317006732	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
290317006733	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
290317006734	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
290317006735	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
290317006736	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
290317006737	Family description; Region: VCBS; pfam13517
290317006738	Family description; Region: VCBS; pfam13517
290317006739	Family description; Region: VCBS; pfam13517
290317006740	Family description; Region: VCBS; pfam13517
290317006741	Family description; Region: VCBS; pfam13517
290317006742	Family description; Region: VCBS; pfam13517
290317006743	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
290317006744	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
290317006745	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
290317006746	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
290317006747	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
290317006748	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
290317006749	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
290317006750	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317006751	Walker A motif; other site
290317006752	ATP binding site [chemical binding]; other site
290317006753	Walker B motif; other site
290317006754	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
290317006755	Integrase core domain; Region: rve; pfam00665
290317006756	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
290317006757	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
290317006758	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
290317006759	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
290317006760	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
290317006761	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
290317006762	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
290317006763	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
290317006764	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
290317006765	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
290317006766	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
290317006767	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
290317006768	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
290317006769	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855
290317006770	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
290317006771	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
290317006772	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562
290317006773	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
290317006774	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563
290317006775	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
290317006776	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
290317006777	active site
290317006778	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290317006779	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
290317006780	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
290317006781	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
290317006782	nucleophilic elbow; other site
290317006783	catalytic triad; other site
290317006784	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
290317006785	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
290317006786	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
290317006787	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
290317006788	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
290317006789	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
290317006790	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
290317006791	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
290317006792	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
290317006793	Transposase; Region: HTH_Tnp_1; cl17663
290317006794	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
290317006795	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
290317006796	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
290317006797	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
290317006798	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
290317006799	N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420
290317006800	Substrate binding site; other site
290317006801	metal-binding site
290317006802	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
290317006803	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
290317006804	active site
290317006805	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
290317006806	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
290317006807	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
290317006808	Vi polysaccharide export ATP-binding protein VexC; Provisional; Region: PRK15177
290317006809	Walker A/P-loop; other site
290317006810	ATP binding site [chemical binding]; other site
290317006811	Q-loop/lid; other site
290317006812	ABC transporter signature motif; other site
290317006813	Walker B; other site
290317006814	D-loop; other site
290317006815	H-loop/switch region; other site
290317006816	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
290317006817	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524
290317006818	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
290317006819	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
290317006820	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
290317006821	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
290317006822	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
290317006823	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
290317006824	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
290317006825	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
290317006826	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
290317006827	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
290317006828	Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185
290317006829	Autotransporter beta-domain; Region: Autotransporter; smart00869
290317006830	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
290317006831	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290317006832	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
290317006833	putative active site [active]
290317006834	heme pocket [chemical binding]; other site
290317006835	PAS domain; Region: PAS; smart00091
290317006836	PAS domain S-box; Region: sensory_box; TIGR00229
290317006837	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290317006838	putative active site [active]
290317006839	heme pocket [chemical binding]; other site
290317006840	PAS domain; Region: PAS_9; pfam13426
290317006841	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290317006842	putative active site [active]
290317006843	heme pocket [chemical binding]; other site
290317006844	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
290317006845	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290317006846	putative active site [active]
290317006847	heme pocket [chemical binding]; other site
290317006848	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
290317006849	dimer interface [polypeptide binding]; other site
290317006850	phosphorylation site [posttranslational modification]
290317006851	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290317006852	ATP binding site [chemical binding]; other site
290317006853	Mg2+ binding site [ion binding]; other site
290317006854	G-X-G motif; other site
290317006855	Response regulator receiver domain; Region: Response_reg; pfam00072
290317006856	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290317006857	active site
290317006858	phosphorylation site [posttranslational modification]
290317006859	intermolecular recognition site; other site
290317006860	dimerization interface [polypeptide binding]; other site
290317006861	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
290317006862	hypothetical protein; Provisional; Region: PRK09256
290317006863	Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528
290317006864	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
290317006865	DNA-binding site [nucleotide binding]; DNA binding site
290317006866	RNA-binding motif; other site
290317006867	FOG: WD40 repeat [General function prediction only]; Region: COG2319
290317006868	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
290317006869	structural tetrad; other site
290317006870	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
290317006871	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
290317006872	active site
290317006873	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
290317006874	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
290317006875	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
290317006876	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
290317006877	putative active site [active]
290317006878	putative metal binding site [ion binding]; other site
290317006879	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
290317006880	bacteriochlorophyll c synthase; Provisional; Region: PRK12392
290317006881	UbiA prenyltransferase family; Region: UbiA; pfam01040
290317006882	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14340
290317006883	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
290317006884	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290317006885	FeS/SAM binding site; other site
290317006886	TRAM domain; Region: TRAM; cl01282
290317006887	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
290317006888	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
290317006889	trimerization site [polypeptide binding]; other site
290317006890	active site
290317006891	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
290317006892	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
290317006893	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
290317006894	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
290317006895	catalytic residue [active]
290317006896	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
290317006897	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
290317006898	dimer interface [polypeptide binding]; other site
290317006899	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290317006900	catalytic residue [active]
290317006901	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
290317006902	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
290317006903	NAD(P) binding site [chemical binding]; other site
290317006904	active site
290317006905	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
290317006906	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
290317006907	non-specific DNA binding site [nucleotide binding]; other site
290317006908	salt bridge; other site
290317006909	sequence-specific DNA binding site [nucleotide binding]; other site
290317006910	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
290317006911	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
290317006912	active site
290317006913	multimer interface [polypeptide binding]; other site
290317006914	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
290317006915	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
290317006916	RNA methyltransferase, RsmE family; Region: TIGR00046
290317006917	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
290317006918	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
290317006919	active site
290317006920	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
290317006921	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
290317006922	nucleotide binding site [chemical binding]; other site
290317006923	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
290317006924	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
290317006925	active site
290317006926	Protein of unknown function (DUF2723); Region: DUF2723; pfam11028
290317006927	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
290317006928	HemN C-terminal domain; Region: HemN_C; pfam06969
290317006929	histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656
290317006930	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
290317006931	active site
290317006932	motif I; other site
290317006933	motif II; other site
290317006934	glycogen synthase; Provisional; Region: PRK14098
290317006935	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
290317006936	ADP-binding pocket [chemical binding]; other site
290317006937	homodimer interface [polypeptide binding]; other site
290317006938	Bacterial Ig-like domain; Region: Big_5; pfam13205
290317006939	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
290317006940	V4R domain; Region: V4R; cl15268
290317006941	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
290317006942	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
290317006943	active site
290317006944	catalytic site [active]
290317006945	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
290317006946	Nitrogen fixation protein of unknown function; Region: Nif11; cl06756
290317006947	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290317006948	S-adenosylmethionine binding site [chemical binding]; other site
290317006949	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
290317006950	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317006951	Walker A motif; other site
290317006952	ATP binding site [chemical binding]; other site
290317006953	Walker B motif; other site
290317006954	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
290317006955	Integrase core domain; Region: rve; pfam00665
290317006956	ATP adenylyltransferase; Region: ATP_transf; pfam09830
290317006957	protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185
290317006958	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
290317006959	P-loop; other site
290317006960	light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910
290317006961	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
290317006962	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
290317006963	light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842
290317006964	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
290317006965	Domain of unknown function DUF77; Region: DUF77; pfam01910
290317006966	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
290317006967	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
290317006968	GDP-binding site [chemical binding]; other site
290317006969	ACT binding site; other site
290317006970	IMP binding site; other site
290317006971	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
290317006972	Dynamin family; Region: Dynamin_N; pfam00350
290317006973	G1 box; other site
290317006974	GTP/Mg2+ binding site [chemical binding]; other site
290317006975	Switch I region; other site
290317006976	G2 box; other site
290317006977	G3 box; other site
290317006978	Switch II region; other site
290317006979	G4 box; other site
290317006980	G5 box; other site
290317006981	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
290317006982	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
290317006983	active site
290317006984	HIGH motif; other site
290317006985	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
290317006986	KMSKS motif; other site
290317006987	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
290317006988	tRNA binding surface [nucleotide binding]; other site
290317006989	anticodon binding site; other site
290317006990	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
290317006991	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
290317006992	Substrate binding site; other site
290317006993	Cupin domain; Region: Cupin_2; cl17218
290317006994	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
290317006995	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
290317006996	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
290317006997	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
290317006998	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
290317006999	alphaNTD homodimer interface [polypeptide binding]; other site
290317007000	alphaNTD - beta interaction site [polypeptide binding]; other site
290317007001	alphaNTD - beta' interaction site [polypeptide binding]; other site
290317007002	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
290317007003	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
290317007004	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
290317007005	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
290317007006	RNA binding surface [nucleotide binding]; other site
290317007007	30S ribosomal protein S11; Validated; Region: PRK05309
290317007008	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
290317007009	30S ribosomal protein S13; Region: bact_S13; TIGR03631
290317007010	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
290317007011	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
290317007012	rRNA binding site [nucleotide binding]; other site
290317007013	predicted 30S ribosome binding site; other site
290317007014	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
290317007015	active site
290317007016	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
290317007017	SecY translocase; Region: SecY; pfam00344
290317007018	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
290317007019	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
290317007020	23S rRNA binding site [nucleotide binding]; other site
290317007021	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
290317007022	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
290317007023	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
290317007024	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
290317007025	5S rRNA interface [nucleotide binding]; other site
290317007026	L27 interface [polypeptide binding]; other site
290317007027	23S rRNA interface [nucleotide binding]; other site
290317007028	L5 interface [polypeptide binding]; other site
290317007029	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
290317007030	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
290317007031	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
290317007032	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
290317007033	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
290317007034	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
290317007035	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
290317007036	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
290317007037	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
290317007038	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
290317007039	RNA binding site [nucleotide binding]; other site
290317007040	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
290317007041	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
290317007042	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
290317007043	putative translocon interaction site; other site
290317007044	23S rRNA interface [nucleotide binding]; other site
290317007045	signal recognition particle (SRP54) interaction site; other site
290317007046	L23 interface [polypeptide binding]; other site
290317007047	trigger factor interaction site; other site
290317007048	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
290317007049	23S rRNA interface [nucleotide binding]; other site
290317007050	5S rRNA interface [nucleotide binding]; other site
290317007051	putative antibiotic binding site [chemical binding]; other site
290317007052	L25 interface [polypeptide binding]; other site
290317007053	L27 interface [polypeptide binding]; other site
290317007054	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
290317007055	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
290317007056	G-X-X-G motif; other site
290317007057	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
290317007058	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
290317007059	putative translocon binding site; other site
290317007060	protein-rRNA interface [nucleotide binding]; other site
290317007061	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
290317007062	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
290317007063	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
290317007064	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
290317007065	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
290317007066	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
290317007067	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
290317007068	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
290317007069	elongation factor Tu; Reviewed; Region: PRK00049
290317007070	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
290317007071	G1 box; other site
290317007072	GEF interaction site [polypeptide binding]; other site
290317007073	GTP/Mg2+ binding site [chemical binding]; other site
290317007074	Switch I region; other site
290317007075	G2 box; other site
290317007076	G3 box; other site
290317007077	Switch II region; other site
290317007078	G4 box; other site
290317007079	G5 box; other site
290317007080	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
290317007081	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
290317007082	Antibiotic Binding Site [chemical binding]; other site
290317007083	elongation factor G; Reviewed; Region: PRK00007
290317007084	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
290317007085	G1 box; other site
290317007086	putative GEF interaction site [polypeptide binding]; other site
290317007087	GTP/Mg2+ binding site [chemical binding]; other site
290317007088	Switch I region; other site
290317007089	G2 box; other site
290317007090	G3 box; other site
290317007091	Switch II region; other site
290317007092	G4 box; other site
290317007093	G5 box; other site
290317007094	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
290317007095	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
290317007096	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
290317007097	30S ribosomal protein S7; Validated; Region: PRK05302
290317007098	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
290317007099	S17 interaction site [polypeptide binding]; other site
290317007100	S8 interaction site; other site
290317007101	16S rRNA interaction site [nucleotide binding]; other site
290317007102	streptomycin interaction site [chemical binding]; other site
290317007103	23S rRNA interaction site [nucleotide binding]; other site
290317007104	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
290317007105	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
290317007106	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
290317007107	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
290317007108	PhnA protein; Region: PhnA; pfam03831
290317007109	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
290317007110	substrate binding site [chemical binding]; other site
290317007111	basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576
290317007112	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
290317007113	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
290317007114	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
290317007115	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
290317007116	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290317007117	putative homodimer interface [polypeptide binding]; other site
290317007118	Methyltransferase domain; Region: Methyltransf_23; pfam13489
290317007119	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
290317007120	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
290317007121	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
290317007122	Probable Catalytic site; other site
290317007123	metal-binding site
290317007124	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
290317007125	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290317007126	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
290317007127	dimerization domain swap beta strand [polypeptide binding]; other site
290317007128	regulatory protein interface [polypeptide binding]; other site
290317007129	active site
290317007130	regulatory phosphorylation site [posttranslational modification]; other site
290317007131	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
290317007132	Coenzyme A binding pocket [chemical binding]; other site
290317007133	GTPase CgtA; Reviewed; Region: obgE; PRK12299
290317007134	GTP1/OBG; Region: GTP1_OBG; pfam01018
290317007135	Obg GTPase; Region: Obg; cd01898
290317007136	G1 box; other site
290317007137	GTP/Mg2+ binding site [chemical binding]; other site
290317007138	Switch I region; other site
290317007139	G2 box; other site
290317007140	G3 box; other site
290317007141	Switch II region; other site
290317007142	G4 box; other site
290317007143	G5 box; other site
290317007144	Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609
290317007145	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
290317007146	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
290317007147	GatB domain; Region: GatB_Yqey; smart00845
290317007148	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
290317007149	Clp amino terminal domain; Region: Clp_N; pfam02861
290317007150	Clp amino terminal domain; Region: Clp_N; pfam02861
290317007151	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317007152	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
290317007153	Walker A motif; other site
290317007154	ATP binding site [chemical binding]; other site
290317007155	Walker B motif; other site
290317007156	arginine finger; other site
290317007157	von Willebrand factor type A domain; Region: VWA_2; pfam13519
290317007158	metal ion-dependent adhesion site (MIDAS); other site
290317007159	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
290317007160	metal ion-dependent adhesion site (MIDAS); other site
290317007161	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
290317007162	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
290317007163	metal ion-dependent adhesion site (MIDAS); other site
290317007164	MoxR-like ATPases [General function prediction only]; Region: COG0714
290317007165	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317007166	Walker A motif; other site
290317007167	ATP binding site [chemical binding]; other site
290317007168	Walker B motif; other site
290317007169	arginine finger; other site
290317007170	UGMP family protein; Validated; Region: PRK09604
290317007171	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
290317007172	Preprotein translocase subunit; Region: YajC; pfam02699
290317007173	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
290317007174	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
290317007175	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
290317007176	catalytic site [active]
290317007177	subunit interface [polypeptide binding]; other site
290317007178	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
290317007179	homodimer interface [polypeptide binding]; other site
290317007180	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290317007181	catalytic residue [active]
290317007182	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
290317007183	binding surface
290317007184	TPR motif; other site
290317007185	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
290317007186	B12 binding site [chemical binding]; other site
290317007187	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
290317007188	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290317007189	FeS/SAM binding site; other site
290317007190	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
290317007191	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
290317007192	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
290317007193	Uncharacterized conserved protein [Function unknown]; Region: COG4095
290317007194	pyrroline-5-carboxylate reductase; Region: PLN02688
290317007195	pyrroline-5-carboxylate reductase; Region: proC; TIGR00112
290317007196	Oxygen tolerance; Region: BatD; pfam13584
290317007197	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
290317007198	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
290317007199	dimer interface [polypeptide binding]; other site
290317007200	putative functional site; other site
290317007201	putative MPT binding site; other site
290317007202	bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604
290317007203	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
290317007204	trimer interface [polypeptide binding]; other site
290317007205	dimer interface [polypeptide binding]; other site
290317007206	putative active site [active]
290317007207	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
290317007208	MPT binding site; other site
290317007209	trimer interface [polypeptide binding]; other site
290317007210	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
290317007211	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
290317007212	active site
290317007213	catalytic site [active]
290317007214	putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MobA; Provisional; Region: PRK14490
290317007215	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
290317007216	Walker A motif; other site
290317007217	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
290317007218	GTP binding site; other site
290317007219	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
290317007220	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
290317007221	ABC-ATPase subunit  interface; other site
290317007222	dimer interface [polypeptide binding]; other site
290317007223	putative PBP binding regions; other site
290317007224	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
290317007225	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
290317007226	Metal binding protein ZntC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018
290317007227	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
290317007228	putative metal binding residues [ion binding]; other site
290317007229	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
290317007230	metal binding site 2 [ion binding]; metal-binding site
290317007231	putative DNA binding helix; other site
290317007232	metal binding site 1 [ion binding]; metal-binding site
290317007233	dimer interface [polypeptide binding]; other site
290317007234	structural Zn2+ binding site [ion binding]; other site
290317007235	2-isopropylmalate synthase; Validated; Region: PRK03739
290317007236	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
290317007237	active site
290317007238	catalytic residues [active]
290317007239	metal binding site [ion binding]; metal-binding site
290317007240	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
290317007241	Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449
290317007242	GIY-YIG motif/motif A; other site
290317007243	putative active site [active]
290317007244	putative metal binding site [ion binding]; other site
290317007245	Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449
290317007246	GIY-YIG motif/motif A; other site
290317007247	putative active site [active]
290317007248	putative metal binding site [ion binding]; other site
290317007249	Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449
290317007250	GIY-YIG motif/motif A; other site
290317007251	putative active site [active]
290317007252	putative metal binding site [ion binding]; other site
290317007253	Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449
290317007254	GIY-YIG motif/motif A; other site
290317007255	putative active site [active]
290317007256	putative metal binding site [ion binding]; other site
290317007257	Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449
290317007258	GIY-YIG motif/motif A; other site
290317007259	putative active site [active]
290317007260	putative metal binding site [ion binding]; other site
290317007261	Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449
290317007262	GIY-YIG motif/motif A; other site
290317007263	putative active site [active]
290317007264	putative metal binding site [ion binding]; other site
290317007265	Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449
290317007266	GIY-YIG motif/motif A; other site
290317007267	putative active site [active]
290317007268	putative metal binding site [ion binding]; other site
290317007269	Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449
290317007270	GIY-YIG motif/motif A; other site
290317007271	putative active site [active]
290317007272	putative metal binding site [ion binding]; other site
290317007273	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
290317007274	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
290317007275	putative phosphate acyltransferase; Provisional; Region: PRK05331
290317007276	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
290317007277	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
290317007278	dimer interface [polypeptide binding]; other site
290317007279	active site
290317007280	CoA binding pocket [chemical binding]; other site
290317007281	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
290317007282	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
290317007283	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
290317007284	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
290317007285	NAD(P) binding site [chemical binding]; other site
290317007286	homotetramer interface [polypeptide binding]; other site
290317007287	homodimer interface [polypeptide binding]; other site
290317007288	active site
290317007289	acyl carrier protein; Provisional; Region: acpP; PRK00982
290317007290	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
290317007291	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
290317007292	dimer interface [polypeptide binding]; other site
290317007293	active site
290317007294	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
290317007295	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
290317007296	dimerization interface [polypeptide binding]; other site
290317007297	active site
290317007298	metal binding site [ion binding]; metal-binding site
290317007299	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
290317007300	dsRNA binding site [nucleotide binding]; other site
290317007301	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
290317007302	tetramer interface [polypeptide binding]; other site
290317007303	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290317007304	catalytic residue [active]
290317007305	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
290317007306	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
290317007307	active site
290317007308	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
290317007309	nucleoside/Zn binding site; other site
290317007310	dimer interface [polypeptide binding]; other site
290317007311	catalytic motif [active]
290317007312	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
290317007313	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
290317007314	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
290317007315	chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014
290317007316	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
290317007317	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
290317007318	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
290317007319	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
290317007320	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
290317007321	active site
290317007322	dimer interface [polypeptide binding]; other site
290317007323	motif 1; other site
290317007324	motif 2; other site
290317007325	motif 3; other site
290317007326	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
290317007327	anticodon binding site; other site
290317007328	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
290317007329	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
290317007330	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
290317007331	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
290317007332	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
290317007333	23S rRNA binding site [nucleotide binding]; other site
290317007334	L21 binding site [polypeptide binding]; other site
290317007335	L13 binding site [polypeptide binding]; other site
290317007336	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
290317007337	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
290317007338	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
290317007339	dimer interface [polypeptide binding]; other site
290317007340	motif 1; other site
290317007341	active site
290317007342	motif 2; other site
290317007343	motif 3; other site
290317007344	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
290317007345	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
290317007346	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
290317007347	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
290317007348	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
290317007349	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
290317007350	dimer interface [polypeptide binding]; other site
290317007351	ssDNA binding site [nucleotide binding]; other site
290317007352	tetramer (dimer of dimers) interface [polypeptide binding]; other site
290317007353	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
290317007354	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
290317007355	putative catalytic site [active]
290317007356	putative metal binding site [ion binding]; other site
290317007357	putative phosphate binding site [ion binding]; other site
290317007358	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
290317007359	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
290317007360	putative active site [active]
290317007361	Domain of Unknown Function (DUF3856); Region: DUF3856; pfam12968
290317007362	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
290317007363	active site
290317007364	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
290317007365	4Fe-4S binding domain; Region: Fer4; cl02805
290317007366	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
290317007367	Cysteine-rich domain; Region: CCG; pfam02754
290317007368	Cysteine-rich domain; Region: CCG; pfam02754
290317007369	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
290317007370	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
290317007371	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
290317007372	active site
290317007373	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
290317007374	Ligand binding site [chemical binding]; other site
290317007375	Electron transfer flavoprotein domain; Region: ETF; pfam01012
290317007376	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
290317007377	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
290317007378	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
290317007379	Mechanosensitive ion channel; Region: MS_channel; pfam00924
290317007380	Helix-turn-helix domain; Region: HTH_17; cl17695
290317007381	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290317007382	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
290317007383	DNA methylase; Region: N6_N4_Mtase; pfam01555
290317007384	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
290317007385	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
290317007386	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
290317007387	Tetratricopeptide repeat; Region: TPR_16; pfam13432
290317007388	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317007389	TPR motif; other site
290317007390	binding surface
290317007391	TPR repeat; Region: TPR_11; pfam13414
290317007392	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317007393	binding surface
290317007394	TPR motif; other site
290317007395	TPR repeat; Region: TPR_11; pfam13414
290317007396	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
290317007397	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
290317007398	metal-binding site [ion binding]
290317007399	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
290317007400	Soluble P-type ATPase [General function prediction only]; Region: COG4087
290317007401	Domain of unknown function (DUF305); Region: DUF305; pfam03713
290317007402	Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990
290317007403	Lipase (class 2); Region: Lipase_2; pfam01674
290317007404	Predicted esterase [General function prediction only]; Region: COG0400
290317007405	trehalose synthase; Region: treS_nterm; TIGR02456
290317007406	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
290317007407	active site
290317007408	catalytic site [active]
290317007409	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
290317007410	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
290317007411	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
290317007412	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
290317007413	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
290317007414	active site
290317007415	homodimer interface [polypeptide binding]; other site
290317007416	catalytic site [active]
290317007417	acceptor binding site [chemical binding]; other site
290317007418	peptide chain release factor 2; Validated; Region: prfB; PRK00578
290317007419	PCRF domain; Region: PCRF; pfam03462
290317007420	RF-1 domain; Region: RF-1; pfam00472
290317007421	Homo sapiens Nbla03831 and related proteins, metallophosphatase domain; Region: MPP_Nbla03831; cd07396
290317007422	active site
290317007423	metal binding site [ion binding]; metal-binding site
290317007424	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
290317007425	competence damage-inducible protein A; Provisional; Region: PRK00549
290317007426	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
290317007427	putative MPT binding site; other site
290317007428	Competence-damaged protein; Region: CinA; pfam02464
290317007429	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
290317007430	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
290317007431	nucleotide binding site [chemical binding]; other site
290317007432	substrate binding site [chemical binding]; other site
290317007433	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
290317007434	dimer interface [polypeptide binding]; other site
290317007435	putative threonine allosteric regulatory site; other site
290317007436	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
290317007437	putative threonine allosteric regulatory site; other site
290317007438	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
290317007439	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
290317007440	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
290317007441	core domain interface [polypeptide binding]; other site
290317007442	delta subunit interface [polypeptide binding]; other site
290317007443	epsilon subunit interface [polypeptide binding]; other site
290317007444	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
290317007445	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
290317007446	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
290317007447	beta subunit interaction interface [polypeptide binding]; other site
290317007448	Walker A motif; other site
290317007449	ATP binding site [chemical binding]; other site
290317007450	Walker B motif; other site
290317007451	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
290317007452	homoserine kinase; Provisional; Region: PRK01212
290317007453	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
290317007454	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
290317007455	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
290317007456	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
290317007457	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290317007458	catalytic residue [active]
290317007459	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
290317007460	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
290317007461	putative acyl-acceptor binding pocket; other site
290317007462	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
290317007463	homopentamer interface [polypeptide binding]; other site
290317007464	active site
290317007465	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
290317007466	dimer interface [polypeptide binding]; other site
290317007467	active site
290317007468	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
290317007469	Ligand Binding Site [chemical binding]; other site
290317007470	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
290317007471	Ligand Binding Site [chemical binding]; other site
290317007472	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
290317007473	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
290317007474	catalytic triad [active]
290317007475	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
290317007476	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
290317007477	active site
290317007478	homodimer interface [polypeptide binding]; other site
290317007479	OstA-like protein; Region: OstA_2; pfam13100
290317007480	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
290317007481	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
290317007482	Recombination protein O N terminal; Region: RecO_N; pfam11967
290317007483	Recombination protein O C terminal; Region: RecO_C; pfam02565
290317007484	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
290317007485	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
290317007486	inhibitor-cofactor binding pocket; inhibition site
290317007487	pyridoxal 5'-phosphate binding site [chemical binding]; other site
290317007488	catalytic residue [active]
290317007489	PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993
290317007490	camphor resistance protein CrcB; Provisional; Region: PRK14202
290317007491	thiosulfate reductase PhsA; Provisional; Region: PRK15488
290317007492	The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755
290317007493	putative [Fe4-S4] binding site [ion binding]; other site
290317007494	putative molybdopterin cofactor binding site [chemical binding]; other site
290317007495	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
290317007496	molybdopterin cofactor binding site; other site
290317007497	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
290317007498	4Fe-4S binding domain; Region: Fer4; cl02805
290317007499	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
290317007500	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
290317007501	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; pfam09603
290317007502	SOUL heme-binding protein; Region: SOUL; pfam04832
290317007503	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
290317007504	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317007505	Walker A motif; other site
290317007506	ATP binding site [chemical binding]; other site
290317007507	Walker B motif; other site
290317007508	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
290317007509	Integrase core domain; Region: rve; pfam00665
290317007510	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
290317007511	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
290317007512	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
290317007513	active site
290317007514	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
290317007515	prephenate dehydrogenase; Validated; Region: PRK08507
290317007516	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
290317007517	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
290317007518	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
290317007519	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
290317007520	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
290317007521	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317007522	Walker A motif; other site
290317007523	ATP binding site [chemical binding]; other site
290317007524	Walker B motif; other site
290317007525	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
290317007526	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
290317007527	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
290317007528	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
290317007529	catalytic core [active]
290317007530	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
290317007531	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
290317007532	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
290317007533	membrane protein; Provisional; Region: PRK14410
290317007534	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
290317007535	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
290317007536	dimerization interface [polypeptide binding]; other site
290317007537	putative ATP binding site [chemical binding]; other site
290317007538	aspartate kinase III; Validated; Region: PRK09084
290317007539	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
290317007540	nucleotide binding site [chemical binding]; other site
290317007541	substrate binding site [chemical binding]; other site
290317007542	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
290317007543	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
290317007544	NlpC/P60 family; Region: NLPC_P60; pfam00877
290317007545	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
290317007546	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290317007547	S-adenosylmethionine binding site [chemical binding]; other site
290317007548	exopolyphosphatase; Region: exo_poly_only; TIGR03706
290317007549	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
290317007550	Methyltransferase domain; Region: Methyltransf_26; pfam13659
290317007551	S-adenosylmethionine binding site [chemical binding]; other site
290317007552	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
290317007553	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
290317007554	acyl-activating enzyme (AAE) consensus motif; other site
290317007555	putative AMP binding site [chemical binding]; other site
290317007556	putative active site [active]
290317007557	putative CoA binding site [chemical binding]; other site
290317007558	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
290317007559	glycerol kinase; Provisional; Region: glpK; PRK00047
290317007560	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
290317007561	N- and C-terminal domain interface [polypeptide binding]; other site
290317007562	active site
290317007563	MgATP binding site [chemical binding]; other site
290317007564	catalytic site [active]
290317007565	metal binding site [ion binding]; metal-binding site
290317007566	glycerol binding site [chemical binding]; other site
290317007567	homotetramer interface [polypeptide binding]; other site
290317007568	homodimer interface [polypeptide binding]; other site
290317007569	FBP binding site [chemical binding]; other site
290317007570	protein IIAGlc interface [polypeptide binding]; other site
290317007571	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
290317007572	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
290317007573	motif II; other site
290317007574	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
290317007575	B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013
290317007576	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
290317007577	FeS/SAM binding site; other site
290317007578	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
290317007579	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
290317007580	active site
290317007581	metal binding site [ion binding]; metal-binding site
290317007582	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), TaA; Region: NGN_SP_TaA; cd09893
290317007583	transcriptional activator RfaH; Region: RfaH; TIGR01955
290317007584	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
290317007585	heterodimer interface [polypeptide binding]; other site
290317007586	homodimer interface [polypeptide binding]; other site
290317007587	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
290317007588	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
290317007589	Substrate binding site; other site
290317007590	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
290317007591	Uncharacterized conserved protein [Function unknown]; Region: COG1434
290317007592	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
290317007593	putative active site [active]
290317007594	6-phosphofructokinase; Provisional; Region: PRK03202
290317007595	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
290317007596	active site
290317007597	ADP/pyrophosphate binding site [chemical binding]; other site
290317007598	dimerization interface [polypeptide binding]; other site
290317007599	allosteric effector site; other site
290317007600	fructose-1,6-bisphosphate binding site; other site
290317007601	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
290317007602	active site
290317007603	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
290317007604	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
290317007605	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
290317007606	Divergent AAA domain; Region: AAA_4; pfam04326
290317007607	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
290317007608	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
290317007609	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
290317007610	glutaminase active site [active]
290317007611	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
290317007612	dimer interface [polypeptide binding]; other site
290317007613	active site
290317007614	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
290317007615	dimer interface [polypeptide binding]; other site
290317007616	active site
290317007617	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
290317007618	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
290317007619	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
290317007620	putative trimer interface [polypeptide binding]; other site
290317007621	putative CoA binding site [chemical binding]; other site
290317007622	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
290317007623	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
290317007624	NADP-binding site; other site
290317007625	homotetramer interface [polypeptide binding]; other site
290317007626	substrate binding site [chemical binding]; other site
290317007627	homodimer interface [polypeptide binding]; other site
290317007628	active site
290317007629	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
290317007630	four helix bundle protein; Region: TIGR02436
290317007631	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
290317007632	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
290317007633	NADP binding site [chemical binding]; other site
290317007634	active site
290317007635	putative substrate binding site [chemical binding]; other site
290317007636	Homeodomain-like domain; Region: HTH_23; pfam13384
290317007637	Winged helix-turn helix; Region: HTH_29; pfam13551
290317007638	Winged helix-turn helix; Region: HTH_33; pfam13592
290317007639	DDE superfamily endonuclease; Region: DDE_3; pfam13358
290317007640	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
290317007641	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
290317007642	Bacterial sugar transferase; Region: Bac_transf; pfam02397
290317007643	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
290317007644	UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232
290317007645	putative NAD(P) binding site [chemical binding]; other site
290317007646	active site
290317007647	putative substrate binding site [chemical binding]; other site
290317007648	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941
290317007649	polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006
290317007650	putative active site [active]
290317007651	putative catalytic site [active]
290317007652	ATP-grasp domain; Region: ATP-grasp_4; cl17255
290317007653	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
290317007654	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
290317007655	trimer interface [polypeptide binding]; other site
290317007656	active site
290317007657	substrate binding site [chemical binding]; other site
290317007658	CoA binding site [chemical binding]; other site
290317007659	Integrase core domain; Region: rve; pfam00665
290317007660	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
290317007661	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
290317007662	Winged helix-turn helix; Region: HTH_29; pfam13551
290317007663	Homeodomain-like domain; Region: HTH_23; cl17451
290317007664	Homeodomain-like domain; Region: HTH_32; pfam13565
290317007665	DDE superfamily endonuclease; Region: DDE_3; pfam13358
290317007666	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
290317007667	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
290317007668	putative active site [active]
290317007669	putative NTP binding site [chemical binding]; other site
290317007670	putative nucleic acid binding site [nucleotide binding]; other site
290317007671	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
290317007672	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
290317007673	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
290317007674	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
290317007675	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
290317007676	metal-binding site
290317007677	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
290317007678	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
290317007679	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
290317007680	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
290317007681	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
290317007682	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
290317007683	NAD(P) binding site [chemical binding]; other site
290317007684	homodimer interface [polypeptide binding]; other site
290317007685	substrate binding site [chemical binding]; other site
290317007686	active site
290317007687	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
290317007688	four helix bundle protein; Region: TIGR02436
290317007689	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
290317007690	oligomeric interface; other site
290317007691	putative active site [active]
290317007692	homodimer interface [polypeptide binding]; other site
290317007693	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
290317007694	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
290317007695	Protein of unknown function (DUF433); Region: DUF433; pfam04255
290317007696	antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870
290317007697	Zn binding site [ion binding]; other site
290317007698	toxin interface [polypeptide binding]; other site
290317007699	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
290317007700	ORF6N domain; Region: ORF6N; pfam10543
290317007701	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
290317007702	putative active site [active]
290317007703	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
290317007704	Chain length determinant protein; Region: Wzz; cl15801
290317007705	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
290317007706	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
290317007707	SLBB domain; Region: SLBB; pfam10531
290317007708	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
290317007709	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317007710	Walker A motif; other site
290317007711	ATP binding site [chemical binding]; other site
290317007712	Walker B motif; other site
290317007713	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
290317007714	Integrase core domain; Region: rve; pfam00665
290317007715	PIN domain; Region: PIN_3; cl17397
290317007716	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
290317007717	Integrase core domain; Region: rve; pfam00665
290317007718	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
290317007719	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317007720	Walker A motif; other site
290317007721	ATP binding site [chemical binding]; other site
290317007722	Walker B motif; other site
290317007723	Transposase [DNA replication, recombination, and repair]; Region: COG5421
290317007724	CTP synthetase; Validated; Region: pyrG; PRK05380
290317007725	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
290317007726	Catalytic site [active]
290317007727	active site
290317007728	UTP binding site [chemical binding]; other site
290317007729	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
290317007730	active site
290317007731	putative oxyanion hole; other site
290317007732	catalytic triad [active]
290317007733	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
290317007734	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
290317007735	DNA gyrase subunit A; Validated; Region: PRK05560
290317007736	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
290317007737	CAP-like domain; other site
290317007738	active site
290317007739	primary dimer interface [polypeptide binding]; other site
290317007740	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
290317007741	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
290317007742	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
290317007743	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
290317007744	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
290317007745	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
290317007746	Oligomerisation domain; Region: Oligomerisation; pfam02410
290317007747	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
290317007748	Glycoprotease family; Region: Peptidase_M22; pfam00814
290317007749	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
290317007750	Uncharacterized conserved protein [Function unknown]; Region: COG4198
290317007751	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
290317007752	ScpA/B protein; Region: ScpA_ScpB; cl00598
290317007753	TPR repeat; Region: TPR_11; pfam13414
290317007754	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317007755	binding surface
290317007756	TPR motif; other site
290317007757	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
290317007758	TPR repeat; Region: TPR_11; pfam13414
290317007759	binding surface
290317007760	TPR motif; other site
290317007761	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
290317007762	active site
290317007763	Nitrogen regulatory protein P-II; Region: P-II; smart00938
290317007764	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
290317007765	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
290317007766	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
290317007767	DPS-like protein, ferritin-like diiron-binding domain; Region: DPSL; cd01052
290317007768	Ferritin-like domain; Region: Ferritin; pfam00210
290317007769	diiron binding motif [ion binding]; other site
290317007770	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
290317007771	TIGR01777 family protein; Region: yfcH
290317007772	putative NAD(P) binding site [chemical binding]; other site
290317007773	putative active site [active]
290317007774	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
290317007775	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
290317007776	glutaminase active site [active]
290317007777	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
290317007778	dimer interface [polypeptide binding]; other site
290317007779	active site
290317007780	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
290317007781	dimer interface [polypeptide binding]; other site
290317007782	active site
290317007783	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
290317007784	active site
290317007785	dimer interface [polypeptide binding]; other site
290317007786	FtsH Extracellular; Region: FtsH_ext; pfam06480
290317007787	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
290317007788	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
290317007789	Walker B motif; other site
290317007790	arginine finger; other site
290317007791	Peptidase family M41; Region: Peptidase_M41; pfam01434
290317007792	acylphosphatase; Provisional; Region: PRK14445
290317007793	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
290317007794	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
290317007795	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
290317007796	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
290317007797	RIP metalloprotease RseP; Region: TIGR00054
290317007798	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
290317007799	active site
290317007800	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
290317007801	protein binding site [polypeptide binding]; other site
290317007802	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
290317007803	protein binding site [polypeptide binding]; other site
290317007804	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
290317007805	putative substrate binding region [chemical binding]; other site
290317007806	peptide chain release factor 1; Validated; Region: prfA; PRK00591
290317007807	PCRF domain; Region: PCRF; pfam03462
290317007808	RF-1 domain; Region: RF-1; pfam00472
290317007809	Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139
290317007810	putative FMN binding site [chemical binding]; other site
290317007811	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
290317007812	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
290317007813	active site
290317007814	phosphorylation site [posttranslational modification]
290317007815	intermolecular recognition site; other site
290317007816	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
290317007817	DNA binding residues [nucleotide binding]
290317007818	dimerization interface [polypeptide binding]; other site
290317007819	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
290317007820	putative active site [active]
290317007821	heme pocket [chemical binding]; other site
290317007822	PAS domain S-box; Region: sensory_box; TIGR00229
290317007823	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
290317007824	putative active site [active]
290317007825	heme pocket [chemical binding]; other site
290317007826	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
290317007827	Histidine kinase; Region: HisKA_3; pfam07730
290317007828	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
290317007829	ATP binding site [chemical binding]; other site
290317007830	Mg2+ binding site [ion binding]; other site
290317007831	G-X-G motif; other site
290317007832	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
290317007833	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
290317007834	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
290317007835	dimer interface [polypeptide binding]; other site
290317007836	active site
290317007837	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
290317007838	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
290317007839	Esterase/lipase [General function prediction only]; Region: COG1647
290317007840	Serine hydrolase; Region: Ser_hydrolase; cl17834
290317007841	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
290317007842	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
290317007843	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
290317007844	active site
290317007845	intersubunit interactions; other site
290317007846	catalytic residue [active]
290317007847	deoxyhypusine synthase-like protein; Provisional; Region: PRK02492
290317007848	deoxyhypusine synthase; Region: dhys; TIGR00321
290317007849	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
290317007850	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
290317007851	active site
290317007852	HIGH motif; other site
290317007853	dimer interface [polypeptide binding]; other site
290317007854	KMSKS motif; other site
290317007855	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
290317007856	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
290317007857	motif II; other site
290317007858	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
290317007859	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
290317007860	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
290317007861	active site
290317007862	HIGH motif; other site
290317007863	KMSK motif region; other site
290317007864	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
290317007865	tRNA binding surface [nucleotide binding]; other site
290317007866	anticodon binding site; other site
290317007867	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
290317007868	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
290317007869	active site
290317007870	(T/H)XGH motif; other site
290317007871	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
290317007872	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
290317007873	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
290317007874	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
290317007875	F0F1 ATP synthase subunit B; Provisional; Region: PRK14472
290317007876	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
290317007877	ATP synthase subunit C; Region: ATP-synt_C; cl00466
290317007878	F0F1 ATP synthase subunit A; Provisional; Region: PRK13419
290317007879	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
290317007880	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
290317007881	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
290317007882	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
290317007883	C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716
290317007884	O-methyltransferase; Region: Methyltransf_2; pfam00891
290317007885	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
290317007886	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
290317007887	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
290317007888	cell division protein FtsZ; Validated; Region: PRK09330
290317007889	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
290317007890	nucleotide binding site [chemical binding]; other site
290317007891	SulA interaction site; other site
290317007892	cell division protein FtsA; Region: ftsA; TIGR01174
290317007893	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
290317007894	nucleotide binding site [chemical binding]; other site
290317007895	Cell division protein FtsA; Region: FtsA; pfam14450
290317007896	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
290317007897	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
290317007898	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
290317007899	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
290317007900	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
290317007901	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
290317007902	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
290317007903	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
290317007904	active site
290317007905	homodimer interface [polypeptide binding]; other site
290317007906	cell division protein FtsW; Region: ftsW; TIGR02614
290317007907	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
290317007908	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
290317007909	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
290317007910	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
290317007911	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
290317007912	Mg++ binding site [ion binding]; other site
290317007913	putative catalytic motif [active]
290317007914	putative substrate binding site [chemical binding]; other site
290317007915	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
290317007916	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
290317007917	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
290317007918	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
290317007919	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
290317007920	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
290317007921	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
290317007922	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
290317007923	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
290317007924	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
290317007925	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
290317007926	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
290317007927	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
290317007928	MraW methylase family; Region: Methyltransf_5; cl17771
290317007929	cell division protein MraZ; Reviewed; Region: PRK00326
290317007930	MraZ protein; Region: MraZ; pfam02381
290317007931	MraZ protein; Region: MraZ; pfam02381
290317007932	YacP-like NYN domain; Region: NYN_YacP; pfam05991
290317007933	Chorismate mutase type II; Region: CM_2; pfam01817
290317007934	YceG-like family; Region: YceG; pfam02618
290317007935	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
290317007936	dimerization interface [polypeptide binding]; other site
290317007937	Phosphoglycerate kinase; Region: PGK; pfam00162
290317007938	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
290317007939	substrate binding site [chemical binding]; other site
290317007940	hinge regions; other site
290317007941	ADP binding site [chemical binding]; other site
290317007942	catalytic site [active]
290317007943	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
290317007944	Protein of unknown function (DUF1232); Region: DUF1232; pfam06803
290317007945	TRAM domain; Region: TRAM; cl01282
290317007946	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
290317007947	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
290317007948	S-adenosylmethionine binding site [chemical binding]; other site
290317007949	fructokinase; Reviewed; Region: PRK09557
290317007950	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
290317007951	nucleotide binding site [chemical binding]; other site
290317007952	PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395
290317007953	active site
290317007954	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
290317007955	membrane protein insertase; Provisional; Region: PRK01318
290317007956	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
290317007957	Haemolytic domain; Region: Haemolytic; pfam01809
290317007958	ribonuclease P; Reviewed; Region: rnpA; PRK01903
290317007959	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399