-- dump date 20140619_041320
-- class Genbank::misc_feature
-- table misc_feature_note
-- id note
194439000001 DNA polymerase III subunit beta; Provisional; Region: PRK14941
194439000002 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
194439000003 putative DNA binding surface [nucleotide binding]; other site
194439000004 dimer interface [polypeptide binding]; other site
194439000005 beta-clamp/clamp loader binding surface; other site
194439000006 beta-clamp/translesion DNA polymerase binding surface; other site
194439000007 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
194439000008 DnaA N-terminal domain; Region: DnaA_N; pfam11638
194439000009 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
194439000010 Walker A motif; other site
194439000011 ATP binding site [chemical binding]; other site
194439000012 Walker B motif; other site
194439000013 arginine finger; other site
194439000014 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
194439000015 DnaA box-binding interface [nucleotide binding]; other site
194439000016 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
194439000017 ribonuclease P; Reviewed; Region: rnpA; PRK01903
194439000018 Haemolytic domain; Region: Haemolytic; pfam01809
194439000019 membrane protein insertase; Provisional; Region: PRK01318
194439000020 YidC periplasmic domain; Region: YidC_periplas; pfam14849
194439000021 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
194439000022 PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395
194439000023 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
194439000024 active site
194439000025 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
194439000026 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
194439000027 nucleotide binding site [chemical binding]; other site
194439000028 TRAM domain; Region: TRAM; cl01282
194439000029 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
194439000030 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
194439000031 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
194439000032 S-adenosylmethionine binding site [chemical binding]; other site
194439000033 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
194439000034 active site
194439000035 intersubunit interactions; other site
194439000036 catalytic residue [active]
194439000037 deoxyhypusine synthase-like protein; Provisional; Region: PRK02492
194439000038 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927
194439000039 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
194439000040 active site
194439000041 HIGH motif; other site
194439000042 dimer interface [polypeptide binding]; other site
194439000043 KMSKS motif; other site
194439000044 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
194439000045 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
194439000046 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
194439000047 motif II; other site
194439000048 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
194439000049 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
194439000050 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
194439000051 active site
194439000052 HIGH motif; other site
194439000053 KMSK motif region; other site
194439000054 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
194439000055 tRNA binding surface [nucleotide binding]; other site
194439000056 anticodon binding site; other site
194439000057 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
194439000058 active site
194439000059 (T/H)XGH motif; other site
194439000060 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
194439000061 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
194439000062 F0F1 ATP synthase subunit B; Provisional; Region: PRK14472
194439000063 F0F1 ATP synthase subunit B; Validated; Region: PRK05759
194439000064 ATP synthase subunit C; Region: ATP-synt_C; cl00466
194439000065 F0F1 ATP synthase subunit A; Provisional; Region: PRK13419
194439000066 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
194439000067 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
194439000068 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
194439000069 NAD binding site [chemical binding]; other site
194439000070 homodimer interface [polypeptide binding]; other site
194439000071 active site
194439000072 substrate binding site [chemical binding]; other site
194439000073 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
194439000074 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716
194439000075 O-methyltransferase; Region: Methyltransf_2; pfam00891
194439000076 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
194439000077 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
194439000078 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
194439000079 cell division protein FtsZ; Validated; Region: PRK09330
194439000080 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
194439000081 nucleotide binding site [chemical binding]; other site
194439000082 SulA interaction site; other site
194439000083 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
194439000084 Cell division protein FtsA; Region: FtsA; smart00842
194439000085 Cell division protein FtsA; Region: FtsA; pfam14450
194439000086 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
194439000087 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
194439000088 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
194439000089 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
194439000090 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
194439000091 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
194439000092 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
194439000093 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
194439000094 active site
194439000095 homodimer interface [polypeptide binding]; other site
194439000096 cell division protein FtsW; Region: ftsW; TIGR02614
194439000097 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
194439000098 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
194439000099 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
194439000100 Mg++ binding site [ion binding]; other site
194439000101 putative catalytic motif [active]
194439000102 putative substrate binding site [chemical binding]; other site
194439000103 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
194439000104 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
194439000105 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
194439000106 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
194439000107 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
194439000108 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
194439000109 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
194439000110 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
194439000111 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
194439000112 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
194439000113 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
194439000114 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
194439000115 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
194439000116 cell division protein MraZ; Reviewed; Region: PRK00326
194439000117 MraZ protein; Region: MraZ; pfam02381
194439000118 MraZ protein; Region: MraZ; pfam02381
194439000119 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
194439000120 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
194439000121 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
194439000122 acyl-activating enzyme (AAE) consensus motif; other site
194439000123 AMP binding site [chemical binding]; other site
194439000124 active site
194439000125 CoA binding site [chemical binding]; other site
194439000126 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
194439000127 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
194439000128 inhibitor-cofactor binding pocket; inhibition site
194439000129 pyridoxal 5'-phosphate binding site [chemical binding]; other site
194439000130 catalytic residue [active]
194439000131 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
194439000132 AAA domain; Region: AAA_26; pfam13500
194439000133 biotin biosynthesis protein BioC; Region: BioC; TIGR02072
194439000134 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
194439000135 S-adenosylmethionine binding site [chemical binding]; other site
194439000136 Protein of unknown function (DUF452); Region: DUF452; cl01062
194439000137 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
194439000138 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858
194439000139 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
194439000140 substrate-cofactor binding pocket; other site
194439000141 pyridoxal 5'-phosphate binding site [chemical binding]; other site
194439000142 catalytic residue [active]
194439000143 biotin synthase; Region: bioB; TIGR00433
194439000144 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
194439000145 FeS/SAM binding site; other site
194439000146 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
194439000147 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
194439000148 putative DNA binding site [nucleotide binding]; other site
194439000149 putative Zn2+ binding site [ion binding]; other site
194439000150 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
194439000151 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
194439000152 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
194439000153 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
194439000154 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
194439000155 active site
194439000156 metal binding site [ion binding]; metal-binding site
194439000157 DNA topoisomerase I; Validated; Region: PRK06599
194439000158 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
194439000159 active site
194439000160 interdomain interaction site; other site
194439000161 putative metal-binding site [ion binding]; other site
194439000162 nucleotide binding site [chemical binding]; other site
194439000163 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
194439000164 domain I; other site
194439000165 DNA binding groove [nucleotide binding]
194439000166 phosphate binding site [ion binding]; other site
194439000167 domain II; other site
194439000168 domain III; other site
194439000169 nucleotide binding site [chemical binding]; other site
194439000170 catalytic site [active]
194439000171 domain IV; other site
194439000172 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
194439000173 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
194439000174 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
194439000175 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
194439000176 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
194439000177 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
194439000178 G1 box; other site
194439000179 GTP/Mg2+ binding site [chemical binding]; other site
194439000180 Switch I region; other site
194439000181 G2 box; other site
194439000182 G3 box; other site
194439000183 Switch II region; other site
194439000184 G4 box; other site
194439000185 G5 box; other site
194439000186 Nucleoside recognition; Region: Gate; pfam07670
194439000187 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
194439000188 Nucleoside recognition; Region: Gate; pfam07670
194439000189 FeoA domain; Region: FeoA; pfam04023
194439000190 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
194439000191 nucleotide binding site/active site [active]
194439000192 HIT family signature motif; other site
194439000193 catalytic residue [active]
194439000194 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; pfam09603
194439000195 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514
194439000196 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
194439000197 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
194439000198 metal ion-dependent adhesion site (MIDAS); other site
194439000199 MoxR-like ATPases [General function prediction only]; Region: COG0714
194439000200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
194439000201 Walker A motif; other site
194439000202 ATP binding site [chemical binding]; other site
194439000203 Walker B motif; other site
194439000204 arginine finger; other site
194439000205 UGMP family protein; Validated; Region: PRK09604
194439000206 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
194439000207 Preprotein translocase subunit; Region: YajC; pfam02699
194439000208 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
194439000209 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
194439000210 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
194439000211 catalytic site [active]
194439000212 subunit interface [polypeptide binding]; other site
194439000213 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
194439000214 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
194439000215 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
194439000216 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
194439000217 catalytic residue [active]
194439000218 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
194439000219 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
194439000220 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
194439000221 Radical SAM superfamily; Region: Radical_SAM; pfam04055
194439000222 FeS/SAM binding site; other site
194439000223 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
194439000224 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
194439000225 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
194439000226 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
194439000227 Uncharacterized conserved protein [Function unknown]; Region: COG4095
194439000228 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
194439000229 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
194439000230 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748
194439000231 Oxygen tolerance; Region: BatD; pfam13584
194439000232 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567
194439000233 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
194439000234 active site
194439000235 catalytic site [active]
194439000236 metal binding site [ion binding]; metal-binding site
194439000237 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
194439000238 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
194439000239 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
194439000240 active site
194439000241 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
194439000242 prephenate dehydrogenase; Validated; Region: PRK08507
194439000243 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
194439000244 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
194439000245 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
194439000246 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
194439000247 Walker A motif; other site
194439000248 ATP binding site [chemical binding]; other site
194439000249 Walker B motif; other site
194439000250 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
194439000251 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
194439000252 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
194439000253 catalytic core [active]
194439000254 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
194439000255 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
194439000256 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
194439000257 membrane protein; Provisional; Region: PRK14410
194439000258 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
194439000259 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
194439000260 dimerization interface [polypeptide binding]; other site
194439000261 putative ATP binding site [chemical binding]; other site
194439000262 aspartate kinase III; Validated; Region: PRK09084
194439000263 AAK_AKiii-LysC-EC: Amino Acid Kinase Superfamily (AAK), AKiii-LysC-EC: this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKIII. AKIII is a monofunctional class enzyme (LysC) found in some...; Region: AAK_AKiii-LysC-EC; cd04258
194439000264 nucleotide binding site [chemical binding]; other site
194439000265 putative catalytic residues [active]
194439000266 aspartate binding site [chemical binding]; other site
194439000267 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912
194439000268 dimer interface [polypeptide binding]; other site
194439000269 allosteric regulatory binding pocket; other site
194439000270 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
194439000271 NlpC/P60 family; Region: NLPC_P60; pfam00877
194439000272 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
194439000273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
194439000274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
194439000275 S-adenosylmethionine binding site [chemical binding]; other site
194439000276 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
194439000277 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483
194439000278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
194439000279 S-adenosylmethionine binding site [chemical binding]; other site
194439000280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
194439000281 H+ Antiporter protein; Region: 2A0121; TIGR00900
194439000282 putative substrate translocation pore; other site
194439000283 methionine sulfoxide reductase B; Provisional; Region: PRK00222
194439000284 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
194439000285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
194439000286 putative substrate translocation pore; other site
194439000287 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
194439000288 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
194439000289 HlyD family secretion protein; Region: HlyD_3; pfam13437
194439000290 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
194439000291 Ligand Binding Site [chemical binding]; other site
194439000292 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
194439000293 Outer membrane efflux protein; Region: OEP; pfam02321
194439000294 Outer membrane efflux protein; Region: OEP; pfam02321
194439000295 GAF domain; Region: GAF; pfam01590
194439000296 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
194439000297 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
194439000298 Walker A motif; other site
194439000299 ATP binding site [chemical binding]; other site
194439000300 Walker B motif; other site
194439000301 arginine finger; other site
194439000302 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
194439000303 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
194439000304 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
194439000305 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
194439000306 pyridoxal 5'-phosphate binding site [chemical binding]; other site
194439000307 homodimer interface [polypeptide binding]; other site
194439000308 catalytic residue [active]
194439000309 ACT domain-containing protein [General function prediction only]; Region: COG4747
194439000310 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
194439000311 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882
194439000312 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
194439000313 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
194439000314 acyl-activating enzyme (AAE) consensus motif; other site
194439000315 AMP binding site [chemical binding]; other site
194439000316 active site
194439000317 CoA binding site [chemical binding]; other site
194439000318 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
194439000319 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659
194439000320 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
194439000321 dimer interface [polypeptide binding]; other site
194439000322 PYR/PP interface [polypeptide binding]; other site
194439000323 TPP binding site [chemical binding]; other site
194439000324 substrate binding site [chemical binding]; other site
194439000325 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
194439000326 TPP-binding site; other site
194439000327 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
194439000328 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
194439000329 P loop; other site
194439000330 Nucleotide binding site [chemical binding]; other site
194439000331 DTAP/Switch II; other site
194439000332 Switch I; other site
194439000333 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
194439000334 Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139
194439000335 putative FMN binding site [chemical binding]; other site
194439000336 Ion channel; Region: Ion_trans_2; pfam07885
194439000337 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
194439000338 TrkA-N domain; Region: TrkA_N; pfam02254
194439000339 TrkA-C domain; Region: TrkA_C; pfam02080
194439000340 peptide chain release factor 1; Validated; Region: prfA; PRK00591
194439000341 PCRF domain; Region: PCRF; pfam03462
194439000342 RF-1 domain; Region: RF-1; pfam00472
194439000343 RIP metalloprotease RseP; Region: TIGR00054
194439000344 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
194439000345 active site
194439000346 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
194439000347 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
194439000348 protein binding site [polypeptide binding]; other site
194439000349 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
194439000350 putative substrate binding region [chemical binding]; other site
194439000351 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
194439000352 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
194439000353 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
194439000354 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
194439000355 acylphosphatase; Provisional; Region: PRK14445
194439000356 FtsH Extracellular; Region: FtsH_ext; pfam06480
194439000357 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
194439000358 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
194439000359 Walker A motif; other site
194439000360 ATP binding site [chemical binding]; other site
194439000361 Walker B motif; other site
194439000362 arginine finger; other site
194439000363 Peptidase family M41; Region: Peptidase_M41; pfam01434
194439000364 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
194439000365 active site
194439000366 dimer interface [polypeptide binding]; other site
194439000367 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
194439000368 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
194439000369 glutaminase active site [active]
194439000370 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
194439000371 dimer interface [polypeptide binding]; other site
194439000372 active site
194439000373 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
194439000374 dimer interface [polypeptide binding]; other site
194439000375 active site
194439000376 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
194439000377 TIGR01777 family protein; Region: yfcH
194439000378 putative NAD(P) binding site [chemical binding]; other site
194439000379 putative active site [active]
194439000380 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
194439000381 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
194439000382 Nitrogen regulatory protein P-II; Region: P-II; pfam00543
194439000383 ScpA/B protein; Region: ScpA_ScpB; cl00598
194439000384 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
194439000385 Predicted ATPase or kinase [General function prediction only]; Region: COG0802
194439000386 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
194439000387 Glycoprotease family; Region: Peptidase_M22; pfam00814
194439000388 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
194439000389 DNA gyrase subunit A; Validated; Region: PRK05560
194439000390 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
194439000391 CAP-like domain; other site
194439000392 active site
194439000393 primary dimer interface [polypeptide binding]; other site
194439000394 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
194439000395 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
194439000396 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
194439000397 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
194439000398 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
194439000399 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
194439000400 CTP synthetase; Validated; Region: pyrG; PRK05380
194439000401 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
194439000402 Catalytic site [active]
194439000403 active site
194439000404 UTP binding site [chemical binding]; other site
194439000405 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
194439000406 active site
194439000407 putative oxyanion hole; other site
194439000408 catalytic triad [active]
194439000409 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
194439000410 elongation factor G; Reviewed; Region: PRK12740
194439000411 G1 box; other site
194439000412 putative GEF interaction site [polypeptide binding]; other site
194439000413 GTP/Mg2+ binding site [chemical binding]; other site
194439000414 Switch I region; other site
194439000415 G2 box; other site
194439000416 G3 box; other site
194439000417 Switch II region; other site
194439000418 G4 box; other site
194439000419 G5 box; other site
194439000420 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
194439000421 Elongation Factor G, domain II; Region: EFG_II; pfam14492
194439000422 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
194439000423 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
194439000424 enolase; Provisional; Region: eno; PRK00077
194439000425 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
194439000426 dimer interface [polypeptide binding]; other site
194439000427 metal binding site [ion binding]; metal-binding site
194439000428 substrate binding pocket [chemical binding]; other site
194439000429 Septum formation initiator; Region: DivIC; pfam04977
194439000430 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional; Region: PRK02048
194439000431 GcpE protein; Region: GcpE; pfam04551
194439000432 GcpE protein; Region: GcpE; cl19500
194439000433 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
194439000434 classical (c) SDRs; Region: SDR_c; cd05233
194439000435 NAD(P) binding site [chemical binding]; other site
194439000436 active site
194439000437 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
194439000438 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
194439000439 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
194439000440 putative homodimer interface [polypeptide binding]; other site
194439000441 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
194439000442 heterodimer interface [polypeptide binding]; other site
194439000443 homodimer interface [polypeptide binding]; other site
194439000444 50S ribosomal protein L11; Validated; Region: rplK; PRK00140
194439000445 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
194439000446 23S rRNA interface [nucleotide binding]; other site
194439000447 L7/L12 interface [polypeptide binding]; other site
194439000448 putative thiostrepton binding site; other site
194439000449 L25 interface [polypeptide binding]; other site
194439000450 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
194439000451 mRNA/rRNA interface [nucleotide binding]; other site
194439000452 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
194439000453 23S rRNA interface [nucleotide binding]; other site
194439000454 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
194439000455 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
194439000456 peripheral dimer interface [polypeptide binding]; other site
194439000457 core dimer interface [polypeptide binding]; other site
194439000458 L10 interface [polypeptide binding]; other site
194439000459 L11 interface [polypeptide binding]; other site
194439000460 putative EF-Tu interaction site [polypeptide binding]; other site
194439000461 putative EF-G interaction site [polypeptide binding]; other site
194439000462 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
194439000463 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
194439000464 RPB12 interaction site [polypeptide binding]; other site
194439000465 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478
194439000466 RPB1 interaction site [polypeptide binding]; other site
194439000467 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
194439000468 RPB10 interaction site [polypeptide binding]; other site
194439000469 RPB11 interaction site [polypeptide binding]; other site
194439000470 RPB3 interaction site [polypeptide binding]; other site
194439000471 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
194439000472 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609
194439000473 beta and beta' interface [polypeptide binding]; other site
194439000474 beta' and sigma factor interface [polypeptide binding]; other site
194439000475 Zn-binding [ion binding]; other site
194439000476 active site region [active]
194439000477 catalytic site [active]
194439000478 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
194439000479 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
194439000480 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
194439000481 cleft; other site
194439000482 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
194439000483 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
194439000484 G-loop; other site
194439000485 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site
194439000486 DNA binding site [nucleotide binding]
194439000487 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
194439000488 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
194439000489 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
194439000490 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
194439000491 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
194439000492 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
194439000493 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
194439000494 carboxyltransferase (CT) interaction site; other site
194439000495 biotinylation site [posttranslational modification]; other site
194439000496 elongation factor P; Validated; Region: PRK00529
194439000497 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
194439000498 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
194439000499 RNA binding site [nucleotide binding]; other site
194439000500 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
194439000501 RNA binding site [nucleotide binding]; other site
194439000502 histone-like DNA-binding protein HU; Region: HU; cd13831
194439000503 dimer interface [polypeptide binding]; other site
194439000504 DNA binding site [nucleotide binding]
194439000505 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
194439000506 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
194439000507 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
194439000508 TPP-binding site [chemical binding]; other site
194439000509 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
194439000510 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
194439000511 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
194439000512 dimer interface [polypeptide binding]; other site
194439000513 PYR/PP interface [polypeptide binding]; other site
194439000514 TPP binding site [chemical binding]; other site
194439000515 substrate binding site [chemical binding]; other site
194439000516 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
194439000517 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
194439000518 motif 1; other site
194439000519 active site
194439000520 motif 2; other site
194439000521 motif 3; other site
194439000522 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
194439000523 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
194439000524 Ferredoxin [Energy production and conversion]; Region: COG1146
194439000525 Ferredoxin [Energy production and conversion]; Region: COG1146
194439000526 short chain dehydrogenase; Provisional; Region: PRK07102
194439000527 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
194439000528 NAD(P) binding site [chemical binding]; other site
194439000529 active site
194439000530 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
194439000531 FAD binding domain; Region: FAD_binding_4; pfam01565
194439000532 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
194439000533 GtrA-like protein; Region: GtrA; pfam04138
194439000534 hypothetical protein; Validated; Region: PRK08238
194439000535 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
194439000536 UbiA family of prenyltransferases (PTases), Unknown subgroup; Region: PT_UbiA_2; cd13963
194439000537 putative active site [active]
194439000538 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
194439000539 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
194439000540 Protein of unknown function (DUF705); Region: DUF705; pfam05152
194439000541 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
194439000542 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
194439000543 motif I; other site
194439000544 motif II; other site
194439000545 GMP synthase; Reviewed; Region: guaA; PRK00074
194439000546 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
194439000547 AMP/PPi binding site [chemical binding]; other site
194439000548 candidate oxyanion hole; other site
194439000549 catalytic triad [active]
194439000550 potential glutamine specificity residues [chemical binding]; other site
194439000551 NAD synthetase; Reviewed; Region: nadE; cl17435
194439000552 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
194439000553 ATP Binding subdomain [chemical binding]; other site
194439000554 Ligand Binding sites [chemical binding]; other site
194439000555 Dimerization subdomain; other site
194439000556 Transglycosylase; Region: Transgly; pfam00912
194439000557 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
194439000558 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
194439000559 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
194439000560 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
194439000561 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
194439000562 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
194439000563 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
194439000564 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
194439000565 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
194439000566 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
194439000567 FeS/SAM binding site; other site
194439000568 Helix-hairpin-helix motif; Region: HHH_3; pfam12836
194439000569 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
194439000570 ABC-2 type transporter; Region: ABC2_membrane; cl17235
194439000571 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
194439000572 Daunorubicin/doxorubicin resistance ATP-binding protein; Region: ABC_DrrA; cd03265
194439000573 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
194439000574 Walker A/P-loop; other site
194439000575 ATP binding site [chemical binding]; other site
194439000576 Q-loop/lid; other site
194439000577 ABC transporter signature motif; other site
194439000578 Walker B; other site
194439000579 D-loop; other site
194439000580 H-loop/switch region; other site
194439000581 glycerol kinase; Provisional; Region: glpK; PRK00047
194439000582 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
194439000583 N- and C-terminal domain interface [polypeptide binding]; other site
194439000584 active site
194439000585 MgATP binding site [chemical binding]; other site
194439000586 catalytic site [active]
194439000587 metal binding site [ion binding]; metal-binding site
194439000588 glycerol binding site [chemical binding]; other site
194439000589 homotetramer interface [polypeptide binding]; other site
194439000590 homodimer interface [polypeptide binding]; other site
194439000591 FBP binding site [chemical binding]; other site
194439000592 protein IIAGlc interface [polypeptide binding]; other site
194439000593 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
194439000594 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
194439000595 Cytochrome c; Region: Cytochrom_C; cl11414
194439000596 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
194439000597 Cytochrome c; Region: Cytochrom_C; cl11414
194439000598 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
194439000599 NAD(P) binding site [chemical binding]; other site
194439000600 active site
194439000601 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
194439000602 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
194439000603 Clp amino terminal domain; Region: Clp_N; pfam02861
194439000604 Clp amino terminal domain; Region: Clp_N; pfam02861
194439000605 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
194439000606 Walker A motif; other site
194439000607 ATP binding site [chemical binding]; other site
194439000608 Walker B motif; other site
194439000609 arginine finger; other site
194439000610 UvrB/uvrC motif; Region: UVR; pfam02151
194439000611 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
194439000612 Walker A motif; other site
194439000613 ATP binding site [chemical binding]; other site
194439000614 Walker B motif; other site
194439000615 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
194439000616 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
194439000617 pyridoxal 5'-phosphate binding site [chemical binding]; other site
194439000618 catalytic residue [active]
194439000619 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
194439000620 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
194439000621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
194439000622 active site
194439000623 phosphorylation site [posttranslational modification]
194439000624 intermolecular recognition site; other site
194439000625 dimerization interface [polypeptide binding]; other site
194439000626 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
194439000627 DNA binding site [nucleotide binding]
194439000628 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
194439000629 dimer interface [polypeptide binding]; other site
194439000630 phosphorylation site [posttranslational modification]
194439000631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
194439000632 ATP binding site [chemical binding]; other site
194439000633 Mg2+ binding site [ion binding]; other site
194439000634 G-X-G motif; other site
194439000635 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
194439000636 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
194439000637 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
194439000638 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
194439000639 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
194439000640 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
194439000641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
194439000642 Major Facilitator Superfamily; Region: MFS_1; pfam07690
194439000643 putative substrate translocation pore; other site
194439000644 thiamine monophosphate kinase; Provisional; Region: PRK05731
194439000645 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
194439000646 ATP binding site [chemical binding]; other site
194439000647 dimerization interface [polypeptide binding]; other site
194439000648 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
194439000649 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
194439000650 SRP54-type protein, GTPase domain; Region: SRP54; smart00962
194439000651 GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441
194439000652 GIY-YIG motif/motif A; other site
194439000653 putative active site [active]
194439000654 putative metal binding site [ion binding]; other site
194439000655 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
194439000656 S-adenosylmethionine binding site [chemical binding]; other site
194439000657 SurA N-terminal domain; Region: SurA_N_3; cl07813
194439000658 periplasmic folding chaperone; Provisional; Region: PRK10788
194439000659 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
194439000660 PPIC-type PPIASE domain; Region: Rotamase; pfam00639
194439000661 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
194439000662 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524
194439000663 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
194439000664 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
194439000665 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
194439000666 replicative DNA helicase; Region: DnaB; TIGR00665
194439000667 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
194439000668 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
194439000669 Walker A motif; other site
194439000670 ATP binding site [chemical binding]; other site
194439000671 Walker B motif; other site
194439000672 DNA binding loops [nucleotide binding]
194439000673 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
194439000674 Fe-S cluster binding site [ion binding]; other site
194439000675 active site
194439000676 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
194439000677 Flavoprotein; Region: Flavoprotein; cl19190
194439000678 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127
194439000679 Family of unknown function (DUF490); Region: DUF490; pfam04357
194439000680 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
194439000681 active site
194439000682 HIGH motif; other site
194439000683 nucleotide binding site [chemical binding]; other site
194439000684 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
194439000685 putative acyl-acceptor binding pocket; other site
194439000686 Protein of unknown function (DUF616); Region: DUF616; pfam04765
194439000687 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
194439000688 active site
194439000689 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
194439000690 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
194439000691 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
194439000692 Walker A/P-loop; other site
194439000693 ATP binding site [chemical binding]; other site
194439000694 Q-loop/lid; other site
194439000695 ABC transporter signature motif; other site
194439000696 Walker B; other site
194439000697 D-loop; other site
194439000698 H-loop/switch region; other site
194439000699 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
194439000700 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
194439000701 active site
194439000702 PhoP regulatory network protein YrbL; Region: YrbL-PhoP_reg; cl17608
194439000703 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
194439000704 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
194439000705 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
194439000706 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
194439000707 active site
194439000708 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
194439000709 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
194439000710 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
194439000711 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
194439000712 putative ADP-binding pocket [chemical binding]; other site
194439000713 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
194439000714 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
194439000715 putative ADP-binding pocket [chemical binding]; other site
194439000716 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
194439000717 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
194439000718 putative ADP-binding pocket [chemical binding]; other site
194439000719 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
194439000720 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721
194439000721 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
194439000722 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
194439000723 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
194439000724 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
194439000725 putative NAD(P) binding site [chemical binding]; other site
194439000726 active site
194439000727 putative substrate binding site [chemical binding]; other site
194439000728 CAAX protease self-immunity; Region: Abi; pfam02517
194439000729 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
194439000730 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
194439000731 active site
194439000732 phosphorylation site [posttranslational modification]
194439000733 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
194439000734 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
194439000735 dimer interface [polypeptide binding]; other site
194439000736 motif 1; other site
194439000737 active site
194439000738 motif 2; other site
194439000739 motif 3; other site
194439000740 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
194439000741 anticodon binding site; other site
194439000742 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
194439000743 hypothetical protein; Provisional; Region: PRK14641
194439000744 NusA N-terminal domain; Region: NusA_N; pfam08529
194439000745 transcription termination factor NusA; Region: NusA; TIGR01953
194439000746 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
194439000747 RNA binding site [nucleotide binding]; other site
194439000748 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
194439000749 G-X-X-G motif; other site
194439000750 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
194439000751 G-X-X-G motif; other site
194439000752 Mitochondria Localisation Sequence; Region: AIF-MLS; pfam14962
194439000753 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
194439000754 translation initiation factor IF-2; Region: IF-2; TIGR00487
194439000755 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
194439000756 G1 box; other site
194439000757 putative GEF interaction site [polypeptide binding]; other site
194439000758 GTP/Mg2+ binding site [chemical binding]; other site
194439000759 Switch I region; other site
194439000760 G2 box; other site
194439000761 G3 box; other site
194439000762 Switch II region; other site
194439000763 G4 box; other site
194439000764 G5 box; other site
194439000765 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
194439000766 Translation-initiation factor 2; Region: IF-2; pfam11987
194439000767 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
194439000768 ribosome-binding factor A; Validated; Region: rbfA; PRK00521
194439000769 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
194439000770 RNA binding site [nucleotide binding]; other site
194439000771 active site
194439000772 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
194439000773 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
194439000774 active site
194439000775 Riboflavin kinase; Region: Flavokinase; smart00904
194439000776 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
194439000777 16S/18S rRNA binding site [nucleotide binding]; other site
194439000778 S13e-L30e interaction site [polypeptide binding]; other site
194439000779 25S rRNA binding site [nucleotide binding]; other site
194439000780 hypothetical protein; Provisional; Region: PRK11820
194439000781 YicC-like family, N-terminal region; Region: YicC_N; pfam03755
194439000782 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
194439000783 Guanylate kinase; Region: Guanylate_kin; pfam00625
194439000784 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
194439000785 catalytic site [active]
194439000786 G-X2-G-X-G-K; other site
194439000787 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
194439000788 active site
194439000789 metal binding site [ion binding]; metal-binding site
194439000790 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
194439000791 active site
194439000792 ADP/pyrophosphate binding site [chemical binding]; other site
194439000793 dimerization interface [polypeptide binding]; other site
194439000794 allosteric effector site; other site
194439000795 fructose-1,6-bisphosphate binding site; other site
194439000796 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
194439000797 Substrate binding site; other site
194439000798 Mg++ binding site; other site
194439000799 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
194439000800 tetramerization interface [polypeptide binding]; other site
194439000801 active site
194439000802 Lipopolysaccharide-assembly, LptC-related; Region: LptC; cl01200
194439000803 Outer membrane protein (OmpH-like); Region: OmpH; smart00935
194439000804 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
194439000805 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
194439000806 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
194439000807 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
194439000808 substrate binding pocket [chemical binding]; other site
194439000809 chain length determination region; other site
194439000810 substrate-Mg2+ binding site; other site
194439000811 catalytic residues [active]
194439000812 aspartate-rich region 1; other site
194439000813 active site lid residues [active]
194439000814 aspartate-rich region 2; other site
194439000815 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
194439000816 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
194439000817 homotetramer interface [polypeptide binding]; other site
194439000818 FMN binding site [chemical binding]; other site
194439000819 homodimer contacts [polypeptide binding]; other site
194439000820 putative active site [active]
194439000821 putative substrate binding site [chemical binding]; other site
194439000822 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
194439000823 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
194439000824 FtsX-like permease family; Region: FtsX; pfam02687
194439000825 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
194439000826 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
194439000827 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
194439000828 Walker A/P-loop; other site
194439000829 ATP binding site [chemical binding]; other site
194439000830 Q-loop/lid; other site
194439000831 ABC transporter signature motif; other site
194439000832 Walker B; other site
194439000833 D-loop; other site
194439000834 H-loop/switch region; other site
194439000835 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
194439000836 This PGM-like (phosphoglucomutase-like) domain is located C-terminal to a mannose-1-phosphate guanyltransferase domain in a protein of unknown function that is found in both prokaryotes and eukaryotes. This domain belongs to the alpha-D-phosphohexomutase...; Region: PGM_like4; cd05803
194439000837 active site
194439000838 substrate binding site [chemical binding]; other site
194439000839 metal binding site [ion binding]; metal-binding site
194439000840 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
194439000841 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
194439000842 RuvA N terminal domain; Region: RuvA_N; pfam01330
194439000843 Helix-hairpin-helix domain; Region: HHH_5; pfam14520
194439000844 RuvA, C-terminal domain; Region: RuvA_C; pfam07499
194439000845 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
194439000846 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
194439000847 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
194439000848 transcription termination factor Rho; Provisional; Region: rho; PRK09376
194439000849 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
194439000850 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
194439000851 RNA binding site [nucleotide binding]; other site
194439000852 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
194439000853 multimer interface [polypeptide binding]; other site
194439000854 Walker A motif; other site
194439000855 ATP binding site [chemical binding]; other site
194439000856 Walker B motif; other site
194439000857 Bifunctional nuclease; Region: DNase-RNase; pfam02577
194439000858 UvrB/uvrC motif; Region: UVR; pfam02151
194439000859 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
194439000860 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
194439000861 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
194439000862 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
194439000863 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
194439000864 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
194439000865 Surface antigen; Region: Bac_surface_Ag; pfam01103
194439000866 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475
194439000867 active site
194439000868 dimer interface [polypeptide binding]; other site
194439000869 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
194439000870 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
194439000871 CoA binding domain; Region: CoA_binding; pfam02629
194439000872 CoA-ligase; Region: Ligase_CoA; pfam00549
194439000873 KpsF/GutQ family protein; Region: kpsF; TIGR00393
194439000874 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
194439000875 putative active site [active]
194439000876 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
194439000877 ATP synthase protein 8; Region: ATP-synt_8; cl03008
194439000878 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
194439000879 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
194439000880 Pyrococcus horikoshii Ph0642 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Ph0642_like; cd07577
194439000881 putative active site [active]
194439000882 catalytic triad [active]
194439000883 dimer interface [polypeptide binding]; other site
194439000884 putative tetramer interface [polypeptide binding]; other site
194439000885 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358
194439000886 Heavy-metal resistance; Region: Metal_resist; pfam13801
194439000887 dimer interface [polypeptide binding]; other site
194439000888 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
194439000889 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
194439000890 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
194439000891 DNA binding residues [nucleotide binding]
194439000892 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
194439000893 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
194439000894 active site
194439000895 substrate binding site [chemical binding]; other site
194439000896 metal binding site [ion binding]; metal-binding site
194439000897 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
194439000898 ipid-A-disaccharide synthase; Provisional; Region: PRK14089
194439000899 Bacterial cellulose synthase subunit; Region: BcsB; cl15851
194439000900 FHIPEP family; Region: FHIPEP; cl07980
194439000901 putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814
194439000902 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
194439000903 catalytic loop [active]
194439000904 iron binding site [ion binding]; other site
194439000905 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691
194439000906 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
194439000907 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
194439000908 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
194439000909 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944
194439000910 Fe-S cluster binding site [ion binding]; other site
194439000911 substrate binding site [chemical binding]; other site
194439000912 catalytic site [active]
194439000913 glutamate racemase; Provisional; Region: PRK00865
194439000914 GTP-binding protein YchF; Reviewed; Region: PRK09601
194439000915 YchF GTPase; Region: YchF; cd01900
194439000916 G1 box; other site
194439000917 GTP/Mg2+ binding site [chemical binding]; other site
194439000918 Switch I region; other site
194439000919 G2 box; other site
194439000920 Switch II region; other site
194439000921 G3 box; other site
194439000922 G4 box; other site
194439000923 G5 box; other site
194439000924 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
194439000925 cytidylate kinase; Provisional; Region: cmk; PRK00023
194439000926 AAA domain; Region: AAA_17; cl19128
194439000927 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
194439000928 CMP-binding site; other site
194439000929 The sites determining sugar specificity; other site
194439000930 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
194439000931 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
194439000932 RNA binding site [nucleotide binding]; other site
194439000933 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
194439000934 RNA binding site [nucleotide binding]; other site
194439000935 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
194439000936 RNA binding site [nucleotide binding]; other site
194439000937 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
194439000938 RNA binding site [nucleotide binding]; other site
194439000939 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
194439000940 RNA binding site [nucleotide binding]; other site
194439000941 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164
194439000942 RNA binding site [nucleotide binding]; other site
194439000943 GTPase Era; Reviewed; Region: era; PRK00089
194439000944 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
194439000945 G1 box; other site
194439000946 GTP/Mg2+ binding site [chemical binding]; other site
194439000947 Switch I region; other site
194439000948 G2 box; other site
194439000949 Switch II region; other site
194439000950 G3 box; other site
194439000951 G4 box; other site
194439000952 G5 box; other site
194439000953 KH domain; Region: KH_2; pfam07650
194439000954 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
194439000955 Prominin; Region: Prominin; pfam05478
194439000956 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
194439000957 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
194439000958 transmembrane helices; other site
194439000959 Beta subunit of integration host factor (IHFB); Region: IHF_B; cd13836
194439000960 dimer interface [polypeptide binding]; other site
194439000961 DNA binding site [nucleotide binding]
194439000962 Sulfite exporter TauE/SafE; Region: TauE; pfam01925
194439000963 FtsH Extracellular; Region: FtsH_ext; pfam06480
194439000964 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
194439000965 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
194439000966 Walker A motif; other site
194439000967 ATP binding site [chemical binding]; other site
194439000968 Walker B motif; other site
194439000969 arginine finger; other site
194439000970 Peptidase family M41; Region: Peptidase_M41; pfam01434
194439000971 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
194439000972 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
194439000973 active site
194439000974 HIGH motif; other site
194439000975 KMSKS motif; other site
194439000976 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
194439000977 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802
194439000978 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
194439000979 iron-sulfur cluster [ion binding]; other site
194439000980 [2Fe-2S] cluster binding site [ion binding]; other site
194439000981 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
194439000982 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
194439000983 intrachain domain interface; other site
194439000984 interchain domain interface [polypeptide binding]; other site
194439000985 heme bH binding site [chemical binding]; other site
194439000986 Qi binding site; other site
194439000987 heme bL binding site [chemical binding]; other site
194439000988 Qo binding site; other site
194439000989 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
194439000990 interchain domain interface [polypeptide binding]; other site
194439000991 intrachain domain interface; other site
194439000992 Qi binding site; other site
194439000993 Qo binding site; other site
194439000994 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
194439000995 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128
194439000996 active site
194439000997 catalytic site [active]
194439000998 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
194439000999 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
194439001000 substrate binding site; other site
194439001001 tetramer interface; other site
194439001002 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
194439001003 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
194439001004 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
194439001005 NADP binding site [chemical binding]; other site
194439001006 active site
194439001007 putative substrate binding site [chemical binding]; other site
194439001008 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
194439001009 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
194439001010 NAD binding site [chemical binding]; other site
194439001011 substrate binding site [chemical binding]; other site
194439001012 homodimer interface [polypeptide binding]; other site
194439001013 active site
194439001014 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
194439001015 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
194439001016 Substrate binding site; other site
194439001017 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
194439001018 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
194439001019 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
194439001020 active site
194439001021 HIGH motif; other site
194439001022 KMSKS motif; other site
194439001023 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
194439001024 tRNA binding surface [nucleotide binding]; other site
194439001025 anticodon binding site; other site
194439001026 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
194439001027 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
194439001028 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
194439001029 active site
194439001030 tetramer interface [polypeptide binding]; other site
194439001031 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
194439001032 active site
194439001033 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
194439001034 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
194439001035 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648
194439001036 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
194439001037 AP (apurinic/apyrimidinic) site pocket; other site
194439001038 DNA interaction; other site
194439001039 Metal-binding active site; metal-binding site
194439001040 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
194439001041 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
194439001042 Ligand binding site; other site
194439001043 Putative Catalytic site; other site
194439001044 DXD motif; other site
194439001045 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
194439001046 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
194439001047 FeS/SAM binding site; other site
194439001048 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
194439001049 active site
194439001050 substrate binding site [chemical binding]; other site
194439001051 cosubstrate binding site; other site
194439001052 catalytic site [active]
194439001053 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
194439001054 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421
194439001055 purine monophosphate binding site [chemical binding]; other site
194439001056 dimer interface [polypeptide binding]; other site
194439001057 putative catalytic residues [active]
194439001058 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
194439001059 Protein of unknown function (DUF456); Region: DUF456; pfam04306
194439001060 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
194439001061 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
194439001062 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
194439001063 Uncharacterized conserved protein [Function unknown]; Region: COG3349
194439001064 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
194439001065 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
194439001066 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
194439001067 iron-sulfur cluster [ion binding]; other site
194439001068 [2Fe-2S] cluster binding site [ion binding]; other site
194439001069 Beta-lactamase; Region: Beta-lactamase; pfam00144
194439001070 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
194439001071 mce related protein; Region: MCE; pfam02470
194439001072 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
194439001073 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
194439001074 Walker A/P-loop; other site
194439001075 ATP binding site [chemical binding]; other site
194439001076 Q-loop/lid; other site
194439001077 ABC transporter signature motif; other site
194439001078 Walker B; other site
194439001079 D-loop; other site
194439001080 H-loop/switch region; other site
194439001081 Permease; Region: Permease; pfam02405
194439001082 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
194439001083 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
194439001084 active site
194439001085 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
194439001086 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
194439001087 active site
194439001088 dimerization interface [polypeptide binding]; other site
194439001089 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
194439001090 active site
194439001091 hydrophilic channel; other site
194439001092 dimerization interface [polypeptide binding]; other site
194439001093 catalytic residues [active]
194439001094 active site lid [active]
194439001095 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
194439001096 Fic/DOC family; Region: Fic; cl00960
194439001097 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
194439001098 MutS domain III; Region: MutS_III; pfam05192
194439001099 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
194439001100 Walker A/P-loop; other site
194439001101 ATP binding site [chemical binding]; other site
194439001102 Q-loop/lid; other site
194439001103 ABC transporter signature motif; other site
194439001104 Walker B; other site
194439001105 D-loop; other site
194439001106 H-loop/switch region; other site
194439001107 Smr domain; Region: Smr; pfam01713
194439001108 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
194439001109 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
194439001110 tetramer interfaces [polypeptide binding]; other site
194439001111 binuclear metal-binding site [ion binding]; other site
194439001112 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
194439001113 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
194439001114 TPP-binding site; other site
194439001115 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
194439001116 PYR/PP interface [polypeptide binding]; other site
194439001117 dimer interface [polypeptide binding]; other site
194439001118 TPP binding site [chemical binding]; other site
194439001119 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
194439001120 Uncharacterized conserved protein [Function unknown]; Region: COG0432
194439001121 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347
194439001122 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128
194439001123 active site
194439001124 catalytic site [active]
194439001125 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
194439001126 aromatic arch; other site
194439001127 DCoH dimer interaction site [polypeptide binding]; other site
194439001128 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
194439001129 DCoH tetramer interaction site [polypeptide binding]; other site
194439001130 substrate binding site [chemical binding]; other site
194439001131 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
194439001132 Part of AAA domain; Region: AAA_19; pfam13245
194439001133 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
194439001134 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
194439001135 Flavoprotein; Region: Flavoprotein; cl19190
194439001136 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
194439001137 FMN binding site [chemical binding]; other site
194439001138 dimer interface [polypeptide binding]; other site
194439001139 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
194439001140 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
194439001141 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
194439001142 P loop; other site
194439001143 Nucleotide binding site [chemical binding]; other site
194439001144 DTAP/Switch II; other site
194439001145 Switch I; other site
194439001146 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
194439001147 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
194439001148 NAD binding site [chemical binding]; other site
194439001149 homotetramer interface [polypeptide binding]; other site
194439001150 homodimer interface [polypeptide binding]; other site
194439001151 substrate binding site [chemical binding]; other site
194439001152 active site
194439001153 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
194439001154 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
194439001155 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
194439001156 putative active site [active]
194439001157 metal binding site [ion binding]; metal-binding site
194439001158 homodimer binding site [polypeptide binding]; other site
194439001159 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
194439001160 AMP binding site [chemical binding]; other site
194439001161 metal binding site [ion binding]; metal-binding site
194439001162 active site
194439001163 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
194439001164 DHH family; Region: DHH; pfam01368
194439001165 DHHA1 domain; Region: DHHA1; pfam02272
194439001166 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
194439001167 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
194439001168 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
194439001169 Ligand binding site; other site
194439001170 Putative Catalytic site; other site
194439001171 DXD motif; other site
194439001172 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158
194439001173 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
194439001174 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
194439001175 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
194439001176 active site
194439001177 DNA polymerase; Provisional; Region: PHA03036
194439001178 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297
194439001179 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
194439001180 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
194439001181 inhibitor-cofactor binding pocket; inhibition site
194439001182 pyridoxal 5'-phosphate binding site [chemical binding]; other site
194439001183 catalytic residue [active]
194439001184 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
194439001185 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
194439001186 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
194439001187 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
194439001188 AIR carboxylase; Region: AIRC; pfam00731
194439001189 coproporphyrinogen III oxidase; Provisional; Region: PRK09249
194439001190 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
194439001191 FeS/SAM binding site; other site
194439001192 HemN C-terminal domain; Region: HemN_C; pfam06969
194439001193 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
194439001194 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
194439001195 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
194439001196 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
194439001197 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
194439001198 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
194439001199 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
194439001200 Walker A/P-loop; other site
194439001201 ATP binding site [chemical binding]; other site
194439001202 Q-loop/lid; other site
194439001203 ABC transporter signature motif; other site
194439001204 Walker B; other site
194439001205 D-loop; other site
194439001206 ABC transporter; Region: ABC_tran_2; pfam12848
194439001207 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
194439001208 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
194439001209 Outer membrane efflux protein; Region: OEP; pfam02321
194439001210 Outer membrane efflux protein; Region: OEP; pfam02321
194439001211 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
194439001212 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
194439001213 HlyD family secretion protein; Region: HlyD_3; pfam13437
194439001214 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
194439001215 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
194439001216 Walker A/P-loop; other site
194439001217 ATP binding site [chemical binding]; other site
194439001218 Q-loop/lid; other site
194439001219 ABC transporter signature motif; other site
194439001220 Walker B; other site
194439001221 D-loop; other site
194439001222 H-loop/switch region; other site
194439001223 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
194439001224 FtsX-like permease family; Region: FtsX; pfam02687
194439001225 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
194439001226 ATP-grasp domain; Region: ATP-grasp_2; pfam08442
194439001227 CoA-ligase; Region: Ligase_CoA; pfam00549
194439001228 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
194439001229 nucleoside/Zn binding site; other site
194439001230 dimer interface [polypeptide binding]; other site
194439001231 catalytic motif [active]
194439001232 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
194439001233 Methyltransferase domain; Region: Methyltransf_31; pfam13847
194439001234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
194439001235 S-adenosylmethionine binding site [chemical binding]; other site
194439001236 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922
194439001237 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
194439001238 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
194439001239 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
194439001240 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
194439001241 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
194439001242 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
194439001243 active site
194439001244 SAM binding site [chemical binding]; other site
194439001245 homodimer interface [polypeptide binding]; other site
194439001246 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
194439001247 active site
194439001248 putative homodimer interface [polypeptide binding]; other site
194439001249 SAM binding site [chemical binding]; other site
194439001250 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
194439001251 S-adenosylmethionine binding site [chemical binding]; other site
194439001252 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
194439001253 active site
194439001254 SAM binding site [chemical binding]; other site
194439001255 homodimer interface [polypeptide binding]; other site
194439001256 Precorrin-8X methylmutase; Region: CbiC; pfam02570
194439001257 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
194439001258 active site
194439001259 SAM binding site [chemical binding]; other site
194439001260 homodimer interface [polypeptide binding]; other site
194439001261 Cobalt chelatase (CbiK); Region: CbiK; pfam06180
194439001262 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412
194439001263 active site
194439001264 C-terminal domain interface [polypeptide binding]; other site
194439001265 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
194439001266 active site
194439001267 N-terminal domain interface [polypeptide binding]; other site
194439001268 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
194439001269 active site
194439001270 SAM binding site [chemical binding]; other site
194439001271 homodimer interface [polypeptide binding]; other site
194439001272 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13636
194439001273 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
194439001274 Walker A/P-loop; other site
194439001275 ATP binding site [chemical binding]; other site
194439001276 Q-loop/lid; other site
194439001277 ABC transporter signature motif; other site
194439001278 Walker B; other site
194439001279 D-loop; other site
194439001280 H-loop/switch region; other site
194439001281 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
194439001282 cobalt transport protein CbiN; Provisional; Region: PRK02898
194439001283 cobalt transport protein CbiM; Validated; Region: PRK08319
194439001284 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
194439001285 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
194439001286 FMN binding site [chemical binding]; other site
194439001287 substrate binding site [chemical binding]; other site
194439001288 putative catalytic residue [active]
194439001289 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
194439001290 catalytic core [active]
194439001291 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
194439001292 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
194439001293 active site
194439001294 dimer interface [polypeptide binding]; other site
194439001295 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
194439001296 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
194439001297 active site
194439001298 FMN binding site [chemical binding]; other site
194439001299 substrate binding site [chemical binding]; other site
194439001300 3Fe-4S cluster binding site [ion binding]; other site
194439001301 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
194439001302 domain interface; other site
194439001303 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
194439001304 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691
194439001305 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
194439001306 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
194439001307 NAD(P) binding site [chemical binding]; other site
194439001308 Domain of unknown function (DUF4404); Region: DUF4404; pfam14357
194439001309 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
194439001310 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
194439001311 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
194439001312 Walker A motif; other site
194439001313 ATP binding site [chemical binding]; other site
194439001314 Walker B motif; other site
194439001315 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
194439001316 Ferredoxin [Energy production and conversion]; Region: COG1146
194439001317 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
194439001318 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141
194439001319 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
194439001320 putative ligand binding site [chemical binding]; other site
194439001321 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
194439001322 ABC-ATPase subunit interface; other site
194439001323 dimer interface [polypeptide binding]; other site
194439001324 putative PBP binding regions; other site
194439001325 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
194439001326 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
194439001327 Walker A/P-loop; other site
194439001328 ATP binding site [chemical binding]; other site
194439001329 Q-loop/lid; other site
194439001330 ABC transporter signature motif; other site
194439001331 Walker B; other site
194439001332 D-loop; other site
194439001333 H-loop/switch region; other site
194439001334 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
194439001335 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
194439001336 intersubunit interface [polypeptide binding]; other site
194439001337 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955
194439001338 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
194439001339 active site
194439001340 catalytic triad [active]
194439001341 dimer interface [polypeptide binding]; other site
194439001342 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
194439001343 active site
194439001344 catalytic triad [active]
194439001345 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
194439001346 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
194439001347 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
194439001348 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055
194439001349 FeS/SAM binding site; other site
194439001350 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
194439001351 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
194439001352 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
194439001353 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
194439001354 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
194439001355 Walker A motif; other site
194439001356 ATP binding site [chemical binding]; other site
194439001357 Walker B motif; other site
194439001358 arginine finger; other site
194439001359 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
194439001360 metal ion-dependent adhesion site (MIDAS); other site
194439001361 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
194439001362 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
194439001363 Walker A motif; other site
194439001364 ATP binding site [chemical binding]; other site
194439001365 Walker B motif; other site
194439001366 arginine finger; other site
194439001367 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
194439001368 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
194439001369 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
194439001370 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
194439001371 N-terminal plug; other site
194439001372 ligand-binding site [chemical binding]; other site
194439001373 Transposase, Mutator family; Region: Transposase_mut; cl19537
194439001374 Flp/Fap pilin component; Region: Flp_Fap; pfam04964
194439001375 Flp/Fap pilin component; Region: Flp_Fap; pfam04964
194439001376 Flp/Fap pilin component; Region: Flp_Fap; pfam04964
194439001377 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
194439001378 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
194439001379 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
194439001380 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
194439001381 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
194439001382 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
194439001383 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
194439001384 ATP binding site [chemical binding]; other site
194439001385 Walker A motif; other site
194439001386 hexamer interface [polypeptide binding]; other site
194439001387 Walker B motif; other site
194439001388 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
194439001389 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
194439001390 Flp/Fap pilin component; Region: Flp_Fap; pfam04964
194439001391 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
194439001392 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
194439001393 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
194439001394 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
194439001395 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
194439001396 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
194439001397 Ligand binding site; other site
194439001398 Putative Catalytic site; other site
194439001399 DXD motif; other site
194439001400 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
194439001401 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690
194439001402 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
194439001403 Transposase; Region: DDE_Tnp_ISL3; pfam01610
194439001404 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
194439001405 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158
194439001406 ATP-binding cassette domain of the molybdenum transport system; Region: ABC_ModC_molybdenum_transporter; cd03297
194439001407 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142
194439001408 Walker A/P-loop; other site
194439001409 ATP binding site [chemical binding]; other site
194439001410 Q-loop/lid; other site
194439001411 ABC transporter signature motif; other site
194439001412 Walker B; other site
194439001413 D-loop; other site
194439001414 H-loop/switch region; other site
194439001415 TOBE domain; Region: TOBE; cl01440
194439001416 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
194439001417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
194439001418 dimer interface [polypeptide binding]; other site
194439001419 conserved gate region; other site
194439001420 putative PBP binding loops; other site
194439001421 ABC-ATPase subunit interface; other site
194439001422 molybdenum transport protein ModD; Provisional; Region: PRK06096
194439001423 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573
194439001424 dimerization interface [polypeptide binding]; other site
194439001425 active site
194439001426 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
194439001427 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
194439001428 Walker A/P-loop; other site
194439001429 ATP binding site [chemical binding]; other site
194439001430 Q-loop/lid; other site
194439001431 ABC transporter signature motif; other site
194439001432 Walker B; other site
194439001433 D-loop; other site
194439001434 H-loop/switch region; other site
194439001435 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
194439001436 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
194439001437 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
194439001438 nucleotide binding pocket [chemical binding]; other site
194439001439 K-X-D-G motif; other site
194439001440 catalytic site [active]
194439001441 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
194439001442 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
194439001443 Helix-hairpin-helix motif; Region: HHH_2; pfam12826
194439001444 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
194439001445 Dimer interface [polypeptide binding]; other site
194439001446 BRCT sequence motif; other site
194439001447 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
194439001448 thioesterase domain, putative; Region: yiiD_Cterm; TIGR02447
194439001449 Protein of unknown function (DUF497); Region: DUF497; pfam04365
194439001450 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
194439001451 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
194439001452 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
194439001453 S-adenosylmethionine binding site [chemical binding]; other site
194439001454 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
194439001455 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
194439001456 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
194439001457 HlyD family secretion protein; Region: HlyD_3; pfam13437
194439001458 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
194439001459 active site
194439001460 Uncharacterized conserved protein [Function unknown]; Region: COG1432
194439001461 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
194439001462 putative metal binding site [ion binding]; other site
194439001463 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
194439001464 sec-independent translocase; Provisional; Region: PRK00708
194439001465 Membrane transport protein; Region: Mem_trans; cl09117
194439001466 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397
194439001467 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
194439001468 nickel responsive regulator; Provisional; Region: PRK04460
194439001469 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
194439001470 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
194439001471 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
194439001472 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691
194439001473 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
194439001474 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
194439001475 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
194439001476 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
194439001477 FAD binding pocket [chemical binding]; other site
194439001478 FAD binding motif [chemical binding]; other site
194439001479 phosphate binding motif [ion binding]; other site
194439001480 beta-alpha-beta structure motif; other site
194439001481 NAD binding pocket [chemical binding]; other site
194439001482 Iron coordination center [ion binding]; other site
194439001483 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142
194439001484 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
194439001485 putative active site [active]
194439001486 oxyanion strand; other site
194439001487 catalytic triad [active]
194439001488 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
194439001489 catalytic residues [active]
194439001490 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
194439001491 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
194439001492 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
194439001493 RNA binding surface [nucleotide binding]; other site
194439001494 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
194439001495 active site
194439001496 Helix-hairpin-helix motif; Region: HHH_3; pfam12836
194439001497 MarC family integral membrane protein; Region: MarC; pfam01914
194439001498 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
194439001499 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
194439001500 NAD(P) binding site [chemical binding]; other site
194439001501 putative active site [active]
194439001502 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
194439001503 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
194439001504 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244
194439001505 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
194439001506 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827
194439001507 Domain of unknown function (DUF389); Region: DUF389; pfam04087
194439001508 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
194439001509 Polysulphide reductase, NrfD; Region: NrfD; cl19193
194439001510 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
194439001511 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
194439001512 thiosulfate reductase PhsA; Provisional; Region: PRK15488
194439001513 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755
194439001514 putative [Fe4-S4] binding site [ion binding]; other site
194439001515 putative molybdopterin cofactor binding site [chemical binding]; other site
194439001516 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778
194439001517 putative molybdopterin cofactor binding site; other site
194439001518 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
194439001519 Nitrogen regulatory protein P-II; Region: P-II; pfam00543
194439001520 Predicted membrane protein (DUF2127); Region: DUF2127; pfam09900
194439001521 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
194439001522 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
194439001523 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
194439001524 DNA binding residues [nucleotide binding]
194439001525 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
194439001526 TM-ABC transporter signature motif; other site
194439001527 ribonuclease R; Region: RNase_R; TIGR02063
194439001528 Ribonuclease B OB domain; Region: OB_RNB; pfam08206
194439001529 RNB domain; Region: RNB; pfam00773
194439001530 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
194439001531 RNA binding site [nucleotide binding]; other site
194439001532 photolyase PhrII; Region: phr2; TIGR00591
194439001533 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
194439001534 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
194439001535 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
194439001536 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
194439001537 catalytic triad [active]
194439001538 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
194439001539 active site residue [active]
194439001540 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
194439001541 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
194439001542 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690
194439001543 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
194439001544 Transposase; Region: DDE_Tnp_ISL3; pfam01610
194439001545 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
194439001546 pyridoxal 5'-phosphate binding site [chemical binding]; other site
194439001547 catalytic residue [active]
194439001548 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
194439001549 OstA-like protein; Region: OstA; cl00844
194439001550 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
194439001551 Putative lysophospholipase; Region: Hydrolase_4; cl19140
194439001552 Predicted transcriptional regulator [Transcription]; Region: COG1959
194439001553 Rrf2 family protein; Region: rrf2_super; TIGR00738
194439001554 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
194439001555 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
194439001556 Walker A/P-loop; other site
194439001557 ATP binding site [chemical binding]; other site
194439001558 Q-loop/lid; other site
194439001559 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
194439001560 ABC transporter signature motif; other site
194439001561 Walker B; other site
194439001562 D-loop; other site
194439001563 H-loop/switch region; other site
194439001564 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
194439001565 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
194439001566 oligomerisation interface [polypeptide binding]; other site
194439001567 mobile loop; other site
194439001568 roof hairpin; other site
194439001569 chaperonin GroEL; Reviewed; Region: groEL; PRK12850
194439001570 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
194439001571 ring oligomerisation interface [polypeptide binding]; other site
194439001572 ATP/Mg binding site [chemical binding]; other site
194439001573 stacking interactions; other site
194439001574 hinge regions; other site
194439001575 PAS domain; Region: PAS_8; pfam13188
194439001576 PAS domain S-box; Region: sensory_box; TIGR00229
194439001577 GAF domain; Region: GAF_2; pfam13185
194439001578 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
194439001579 dimer interface [polypeptide binding]; other site
194439001580 phosphorylation site [posttranslational modification]
194439001581 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
194439001582 ATP binding site [chemical binding]; other site
194439001583 Mg2+ binding site [ion binding]; other site
194439001584 G-X-G motif; other site
194439001585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
194439001586 active site
194439001587 phosphorylation site [posttranslational modification]
194439001588 intermolecular recognition site; other site
194439001589 dimerization interface [polypeptide binding]; other site
194439001590 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
194439001591 Ligand Binding Site [chemical binding]; other site
194439001592 CAAX protease self-immunity; Region: Abi; pfam02517
194439001593 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
194439001594 substrate binding site [chemical binding]; other site
194439001595 active site
194439001596 catalytic residues [active]
194439001597 heterodimer interface [polypeptide binding]; other site
194439001598 Predicted glycosyltransferases [General function prediction only]; Region: COG1216
194439001599 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
194439001600 Probable Catalytic site; other site
194439001601 metal-binding site
194439001602 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866
194439001603 putative hydrophobic ligand binding site [chemical binding]; other site
194439001604 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
194439001605 S-adenosylmethionine synthetase (AdoMet synthetase); Region: AdoMet_Synthase; pfam01941
194439001606 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
194439001607 Domain of unknown function DUF21; Region: DUF21; pfam01595
194439001608 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
194439001609 Transporter associated domain; Region: CorC_HlyC; smart01091
194439001610 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
194439001611 Aconitate B N-terminal domain; Region: Aconitase_B_N; pfam11791
194439001612 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
194439001613 substrate binding site [chemical binding]; other site
194439001614 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
194439001615 substrate binding site [chemical binding]; other site
194439001616 ligand binding site [chemical binding]; other site
194439001617 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
194439001618 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
194439001619 histidinol dehydrogenase; Region: hisD; TIGR00069
194439001620 NAD binding site [chemical binding]; other site
194439001621 dimerization interface [polypeptide binding]; other site
194439001622 product binding site; other site
194439001623 substrate binding site [chemical binding]; other site
194439001624 zinc binding site [ion binding]; other site
194439001625 catalytic residues [active]
194439001626 rod shape-determining protein MreB; Provisional; Region: PRK13930
194439001627 MreB and similar proteins; Region: MreB_like; cd10225
194439001628 nucleotide binding site [chemical binding]; other site
194439001629 Mg binding site [ion binding]; other site
194439001630 putative protofilament interaction site [polypeptide binding]; other site
194439001631 RodZ interaction site [polypeptide binding]; other site
194439001632 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
194439001633 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
194439001634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078
194439001635 active site
194439001636 dimerization interface [polypeptide binding]; other site
194439001637 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
194439001638 DevC protein; Region: devC; TIGR01185
194439001639 FtsX-like permease family; Region: FtsX; pfam02687
194439001640 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
194439001641 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
194439001642 Walker A/P-loop; other site
194439001643 ATP binding site [chemical binding]; other site
194439001644 Q-loop/lid; other site
194439001645 ABC transporter signature motif; other site
194439001646 Walker B; other site
194439001647 D-loop; other site
194439001648 H-loop/switch region; other site
194439001649 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
194439001650 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
194439001651 Outer membrane efflux protein; Region: OEP; pfam02321
194439001652 Outer membrane efflux protein; Region: OEP; pfam02321
194439001653 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275
194439001654 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
194439001655 hinge; other site
194439001656 active site
194439001657 Flagellar FliJ protein; Region: FliJ; pfam02050
194439001658 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
194439001659 Peptidase family M23; Region: Peptidase_M23; pfam01551
194439001660 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
194439001661 homodimer interface [polypeptide binding]; other site
194439001662 NAD binding pocket [chemical binding]; other site
194439001663 ATP binding pocket [chemical binding]; other site
194439001664 Mg binding site [ion binding]; other site
194439001665 active-site loop [active]
194439001666 L-aspartate oxidase; Provisional; Region: PRK09077
194439001667 L-aspartate oxidase; Provisional; Region: PRK06175
194439001668 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
194439001669 pyruvoyl-dependent arginine decarboxylase; Reviewed; Region: PRK01285
194439001670 tyrosyl-tRNA synthetase; Validated; Region: PRK05912
194439001671 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
194439001672 active site
194439001673 HIGH motif; other site
194439001674 dimer interface [polypeptide binding]; other site
194439001675 KMSKS motif; other site
194439001676 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
194439001677 SmpB-tmRNA interface; other site
194439001678 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
194439001679 FAD binding domain; Region: FAD_binding_4; pfam01565
194439001680 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
194439001681 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
194439001682 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717
194439001683 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
194439001684 rod shape-determining protein MreC; Provisional; Region: PRK13922
194439001685 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
194439001686 oligomerisation interface [polypeptide binding]; other site
194439001687 mobile loop; other site
194439001688 roof hairpin; other site
194439001689 quinolinate synthetase; Provisional; Region: PRK09375
194439001690 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915
194439001691 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
194439001692 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
194439001693 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
194439001694 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
194439001695 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
194439001696 NAD(P) binding site [chemical binding]; other site
194439001697 active site
194439001698 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
194439001699 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
194439001700 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
194439001701 active site
194439001702 dimer interface [polypeptide binding]; other site
194439001703 effector binding site; other site
194439001704 Transcriptional regulator; Region: Transcrip_reg; cl00361
194439001705 TSCPD domain; Region: TSCPD; pfam12637
194439001706 carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376
194439001707 starch binding site [chemical binding]; other site
194439001708 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
194439001709 Putative addiction module component; Region: Unstab_antitox; pfam09720
194439001710 Cache domain; Region: Cache_1; pfam02743
194439001711 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
194439001712 nucleoside/Zn binding site; other site
194439001713 dimer interface [polypeptide binding]; other site
194439001714 catalytic motif [active]
194439001715 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
194439001716 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
194439001717 Walker A/P-loop; other site
194439001718 ATP binding site [chemical binding]; other site
194439001719 Q-loop/lid; other site
194439001720 ABC transporter signature motif; other site
194439001721 Walker B; other site
194439001722 D-loop; other site
194439001723 H-loop/switch region; other site
194439001724 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
194439001725 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126
194439001726 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
194439001727 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
194439001728 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951
194439001729 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
194439001730 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
194439001731 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634
194439001732 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268
194439001733 ATP binding site [chemical binding]; other site
194439001734 Mg++ binding site [ion binding]; other site
194439001735 motif III; other site
194439001736 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
194439001737 nucleotide binding region [chemical binding]; other site
194439001738 ATP-binding site [chemical binding]; other site
194439001739 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
194439001740 putative RNA binding site [nucleotide binding]; other site
194439001741 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
194439001742 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
194439001743 Beta-Casp domain; Region: Beta-Casp; smart01027
194439001744 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521
194439001745 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
194439001746 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
194439001747 substrate binding site [chemical binding]; other site
194439001748 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690
194439001749 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139
194439001750 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
194439001751 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
194439001752 active site
194439001753 Int/Topo IB signature motif; other site
194439001754 16S rRNA methyltransferase B; Provisional; Region: PRK14904
194439001755 NusB family; Region: NusB; pfam01029
194439001756 putative RNA binding site [nucleotide binding]; other site
194439001757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
194439001758 S-adenosylmethionine binding site [chemical binding]; other site
194439001759 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
194439001760 homodimer interface [polypeptide binding]; other site
194439001761 substrate-cofactor binding pocket; other site
194439001762 pyridoxal 5'-phosphate binding site [chemical binding]; other site
194439001763 catalytic residue [active]
194439001764 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
194439001765 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
194439001766 seryl-tRNA synthetase; Provisional; Region: PRK05431
194439001767 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
194439001768 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
194439001769 dimer interface [polypeptide binding]; other site
194439001770 active site
194439001771 motif 1; other site
194439001772 motif 2; other site
194439001773 motif 3; other site
194439001774 Yqey-like protein; Region: YqeY; pfam09424
194439001775 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
194439001776 classical (c) SDRs; Region: SDR_c; cd05233
194439001777 NAD(P) binding site [chemical binding]; other site
194439001778 active site
194439001779 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
194439001780 DNA-binding site [nucleotide binding]; DNA binding site
194439001781 RNA-binding motif; other site
194439001782 hypothetical protein; Reviewed; Region: PRK00024
194439001783 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
194439001784 MPN+ (JAMM) motif; other site
194439001785 Zinc-binding site [ion binding]; other site
194439001786 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
194439001787 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
194439001788 active site
194439001789 catalytic residues [active]
194439001790 metal binding site [ion binding]; metal-binding site
194439001791 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
194439001792 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
194439001793 substrate binding site [chemical binding]; other site
194439001794 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
194439001795 substrate binding site [chemical binding]; other site
194439001796 ligand binding site [chemical binding]; other site
194439001797 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
194439001798 ketol-acid reductoisomerase; Provisional; Region: PRK05479
194439001799 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
194439001800 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
194439001801 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
194439001802 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
194439001803 putative valine binding site [chemical binding]; other site
194439001804 dimer interface [polypeptide binding]; other site
194439001805 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
194439001806 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
194439001807 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
194439001808 PYR/PP interface [polypeptide binding]; other site
194439001809 dimer interface [polypeptide binding]; other site
194439001810 TPP binding site [chemical binding]; other site
194439001811 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
194439001812 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
194439001813 TPP-binding site [chemical binding]; other site
194439001814 dimer interface [polypeptide binding]; other site
194439001815 dihydroxy-acid dehydratase; Provisional; Region: PRK00911
194439001816 Tubulin folding cofactor D C terminal; Region: TFCD_C; cl19887
194439001817 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
194439001818 Transcription antiterminator [Transcription]; Region: NusG; COG0250
194439001819 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
194439001820 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
194439001821 putative active site [active]
194439001822 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
194439001823 active site
194439001824 8-oxo-dGMP binding site [chemical binding]; other site
194439001825 nudix motif; other site
194439001826 metal binding site [ion binding]; metal-binding site
194439001827 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359
194439001828 active site
194439001829 phosphorylation site [posttranslational modification]
194439001830 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
194439001831 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
194439001832 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
194439001833 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
194439001834 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
194439001835 motif II; other site
194439001836 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
194439001837 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
194439001838 Integral membrane protein DUF92; Region: DUF92; pfam01940
194439001839 TolQ protein; Region: tolQ; TIGR02796
194439001840 TolR protein; Region: tolR; TIGR02801
194439001841 TolA protein; Region: tolA_full; TIGR02794
194439001842 TonB C terminal; Region: TonB_2; pfam13103
194439001843 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
194439001844 TolB amino-terminal domain; Region: TolB_N; pfam04052
194439001845 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
194439001846 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
194439001847 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
194439001848 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
194439001849 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
194439001850 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
194439001851 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
194439001852 ligand binding site [chemical binding]; other site
194439001853 Protein of unknown function (DUF3251); Region: DUF3251; cl08186
194439001854 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
194439001855 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
194439001856 binding surface
194439001857 TPR motif; other site
194439001858 Photosystem P840 reaction centre protein PscD; Region: RC-P840_PscD; pfam10657
194439001859 C_GCAxxG_C_C family probable redox protein; Region: C_GCAxxG_C_C; TIGR01909
194439001860 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
194439001861 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
194439001862 nucleotide binding site [chemical binding]; other site
194439001863 NEF interaction site [polypeptide binding]; other site
194439001864 SBD interface [polypeptide binding]; other site
194439001865 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
194439001866 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
194439001867 putative dimer interface [polypeptide binding]; other site
194439001868 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
194439001869 dimerization interface [polypeptide binding]; other site
194439001870 putative DNA binding site [nucleotide binding]; other site
194439001871 putative Zn2+ binding site [ion binding]; other site
194439001872 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806
194439001873 Putative zinc-finger; Region: zf-HC2; pfam13490
194439001874 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
194439001875 Sigma-70 region 2; Region: Sigma70_r2; pfam04542
194439001876 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
194439001877 DNA binding residues [nucleotide binding]
194439001878 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
194439001879 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
194439001880 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
194439001881 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
194439001882 hexamer interface [polypeptide binding]; other site
194439001883 ligand binding site [chemical binding]; other site
194439001884 putative active site [active]
194439001885 NAD(P) binding site [chemical binding]; other site
194439001886 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
194439001887 catalytic loop [active]
194439001888 iron binding site [ion binding]; other site
194439001889 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
194439001890 catalytic loop [active]
194439001891 iron binding site [ion binding]; other site
194439001892 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
194439001893 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814
194439001894 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
194439001895 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
194439001896 ATP binding site [chemical binding]; other site
194439001897 putative Mg++ binding site [ion binding]; other site
194439001898 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
194439001899 nucleotide binding region [chemical binding]; other site
194439001900 ATP-binding site [chemical binding]; other site
194439001901 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
194439001902 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
194439001903 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
194439001904 Walker A/P-loop; other site
194439001905 ATP binding site [chemical binding]; other site
194439001906 Q-loop/lid; other site
194439001907 ABC transporter signature motif; other site
194439001908 Walker B; other site
194439001909 D-loop; other site
194439001910 H-loop/switch region; other site
194439001911 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
194439001912 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
194439001913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
194439001914 active site
194439001915 phosphorylation site [posttranslational modification]
194439001916 intermolecular recognition site; other site
194439001917 dimerization interface [polypeptide binding]; other site
194439001918 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
194439001919 DNA binding site [nucleotide binding]
194439001920 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
194439001921 dimerization interface [polypeptide binding]; other site
194439001922 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
194439001923 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
194439001924 putative active site [active]
194439001925 heme pocket [chemical binding]; other site
194439001926 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
194439001927 dimer interface [polypeptide binding]; other site
194439001928 phosphorylation site [posttranslational modification]
194439001929 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
194439001930 ATP binding site [chemical binding]; other site
194439001931 Mg2+ binding site [ion binding]; other site
194439001932 G-X-G motif; other site
194439001933 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
194439001934 Mechanosensitive ion channel; Region: MS_channel; pfam00924
194439001935 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
194439001936 nudix motif; other site
194439001937 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
194439001938 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
194439001939 catalytic triad [active]
194439001940 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622
194439001941 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
194439001942 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
194439001943 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
194439001944 Walker A/P-loop; other site
194439001945 ATP binding site [chemical binding]; other site
194439001946 Q-loop/lid; other site
194439001947 ABC transporter signature motif; other site
194439001948 Walker B; other site
194439001949 D-loop; other site
194439001950 H-loop/switch region; other site
194439001951 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
194439001952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
194439001953 dimer interface [polypeptide binding]; other site
194439001954 conserved gate region; other site
194439001955 putative PBP binding loops; other site
194439001956 ABC-ATPase subunit interface; other site
194439001957 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
194439001958 Integrase core domain; Region: rve; pfam00665
194439001959 DNA binding domain, excisionase family; Region: excise; TIGR01764
194439001960 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
194439001961 HsdM N-terminal domain; Region: HsdM_N; pfam12161
194439001962 Methyltransferase domain; Region: Methyltransf_26; pfam13659
194439001963 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
194439001964 Divergent AAA domain; Region: AAA_4; pfam04326
194439001965 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
194439001966 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
194439001967 Fic/DOC family N-terminal; Region: Fic_N; pfam13784
194439001968 Fic family protein [Function unknown]; Region: COG3177
194439001969 Fic/DOC family; Region: Fic; pfam02661
194439001970 HTH DNA binding domain; Region: HTH_13; pfam11972
194439001971 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
194439001972 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
194439001973 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
194439001974 Abortive infection C-terminus; Region: Abi_C; pfam14355
194439001975 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
194439001976 AAA domain; Region: AAA_13; pfam13166
194439001977 Walker A/P-loop; other site
194439001978 AAA domain; Region: AAA_21; pfam13304
194439001979 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
194439001980 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
194439001981 active site
194439001982 8-oxo-dGMP binding site [chemical binding]; other site
194439001983 nudix motif; other site
194439001984 metal binding site [ion binding]; metal-binding site
194439001985 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
194439001986 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
194439001987 active site
194439001988 NTP binding site [chemical binding]; other site
194439001989 metal binding triad [ion binding]; metal-binding site
194439001990 antibiotic binding site [chemical binding]; other site
194439001991 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
194439001992 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
194439001993 ATP binding site [chemical binding]; other site
194439001994 substrate interface [chemical binding]; other site
194439001995 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
194439001996 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
194439001997 FeS/SAM binding site; other site
194439001998 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
194439001999 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
194439002000 ThiS interaction site; other site
194439002001 putative active site [active]
194439002002 tetramer interface [polypeptide binding]; other site
194439002003 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
194439002004 thiS-thiF/thiG interaction site; other site
194439002005 cysteine synthase; Region: PLN02565
194439002006 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
194439002007 dimer interface [polypeptide binding]; other site
194439002008 pyridoxal 5'-phosphate binding site [chemical binding]; other site
194439002009 catalytic residue [active]
194439002010 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
194439002011 homodimer interface [polypeptide binding]; other site
194439002012 substrate-cofactor binding pocket; other site
194439002013 pyridoxal 5'-phosphate binding site [chemical binding]; other site
194439002014 catalytic residue [active]
194439002015 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
194439002016 Protein of unknown function DUF45; Region: DUF45; pfam01863
194439002017 Protein of unknown function (DUF3959); Region: DUF3959; pfam13105
194439002018 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
194439002019 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
194439002020 hexamer interface [polypeptide binding]; other site
194439002021 ligand binding site [chemical binding]; other site
194439002022 putative active site [active]
194439002023 NAD(P) binding site [chemical binding]; other site
194439002024 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
194439002025 trimer interface [polypeptide binding]; other site
194439002026 putative Zn binding site [ion binding]; other site
194439002027 TspO/MBR family; Region: TspO_MBR; pfam03073
194439002028 SurA N-terminal domain; Region: SurA_N_3; cl07813
194439002029 peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925
194439002030 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
194439002031 putative transporter; Provisional; Region: PRK11660
194439002032 Sulfate transporter family; Region: Sulfate_transp; pfam00916
194439002033 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
194439002034 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
194439002035 putative cation:proton antiport protein; Provisional; Region: PRK10669
194439002036 TrkA-N domain; Region: TrkA_N; pfam02254
194439002037 Putative lysophospholipase; Region: Hydrolase_4; cl19140
194439002038 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
194439002039 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
194439002040 active site
194439002041 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
194439002042 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
194439002043 NAD binding domain of methylene-tetrahydrofolate dehydrogenase; Region: NAD_bind_m-THF_DH; cd01079
194439002044 NAD binding site [chemical binding]; other site
194439002045 putative homodimer interface [polypeptide binding]; other site
194439002046 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
194439002047 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
194439002048 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
194439002049 homotetramer interface [polypeptide binding]; other site
194439002050 ligand binding site [chemical binding]; other site
194439002051 catalytic site [active]
194439002052 NAD binding site [chemical binding]; other site
194439002053 S-adenosylmethionine synthetase; Validated; Region: PRK05250
194439002054 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
194439002055 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
194439002056 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
194439002057 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
194439002058 active site
194439002059 metal binding site [ion binding]; metal-binding site
194439002060 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
194439002061 active site
194439002062 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
194439002063 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
194439002064 active site
194439002065 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
194439002066 putative trimer interface [polypeptide binding]; other site
194439002067 putative CoA binding site [chemical binding]; other site
194439002068 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
194439002069 nudix motif; other site
194439002070 phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Region: pheT_bact; TIGR00472
194439002071 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
194439002072 putative tRNA-binding site [nucleotide binding]; other site
194439002073 B3/4 domain; Region: B3_4; pfam03483
194439002074 tRNA synthetase B5 domain; Region: B5; smart00874
194439002075 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769
194439002076 dimer interface [polypeptide binding]; other site
194439002077 motif 1; other site
194439002078 motif 3; other site
194439002079 motif 2; other site
194439002080 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
194439002081 Cell division protein ZapA; Region: ZapA; pfam05164
194439002082 phosphodiesterase; Provisional; Region: PRK12704
194439002083 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
194439002084 KH domain; Region: KH_1; pfam00013
194439002085 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
194439002086 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
194439002087 putative active site pocket [active]
194439002088 4-fold oligomerization interface [polypeptide binding]; other site
194439002089 metal binding residues [ion binding]; metal-binding site
194439002090 3-fold/trimer interface [polypeptide binding]; other site
194439002091 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
194439002092 protein translocase, SecG subunit; Region: secG; TIGR00810
194439002093 Protein of unknown function (DUF975); Region: DUF975; cl10504
194439002094 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
194439002095 Sulfite exporter TauE/SafE; Region: TauE; pfam01925
194439002096 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843
194439002097 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
194439002098 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
194439002099 Domain of unknown function (DUF814); Region: DUF814; pfam05670
194439002100 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
194439002101 catalytic motif [active]
194439002102 Zn binding site [ion binding]; other site
194439002103 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
194439002104 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
194439002105 catalytic motif [active]
194439002106 Zn binding site [ion binding]; other site
194439002107 RibD C-terminal domain; Region: RibD_C; cl17279
194439002108 DoxX; Region: DoxX; pfam07681
194439002109 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
194439002110 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
194439002111 Walker A/P-loop; other site
194439002112 ATP binding site [chemical binding]; other site
194439002113 Q-loop/lid; other site
194439002114 ABC transporter signature motif; other site
194439002115 Walker B; other site
194439002116 D-loop; other site
194439002117 H-loop/switch region; other site
194439002118 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
194439002119 dimer interface [polypeptide binding]; other site
194439002120 catalytic triad [active]
194439002121 peroxidatic and resolving cysteines [active]
194439002122 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_5; cd11352
194439002123 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128
194439002124 active site
194439002125 catalytic site [active]
194439002126 riboflavin synthase subunit alpha; Provisional; Region: PRK09289
194439002127 Lumazine binding domain; Region: Lum_binding; pfam00677
194439002128 Lumazine binding domain; Region: Lum_binding; pfam00677
194439002129 recombination factor protein RarA; Reviewed; Region: PRK13342
194439002130 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
194439002131 Walker A motif; other site
194439002132 ATP binding site [chemical binding]; other site
194439002133 Walker B motif; other site
194439002134 arginine finger; other site
194439002135 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
194439002136 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
194439002137 Outer membrane efflux protein; Region: OEP; pfam02321
194439002138 Outer membrane efflux protein; Region: OEP; pfam02321
194439002139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
194439002140 S-adenosylmethionine binding site [chemical binding]; other site
194439002141 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
194439002142 nucleotide binding site/active site [active]
194439002143 HIT family signature motif; other site
194439002144 catalytic residue [active]
194439002145 Ferrochelatase; Region: Ferrochelatase; pfam00762
194439002146 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
194439002147 C-terminal domain interface [polypeptide binding]; other site
194439002148 active site
194439002149 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
194439002150 active site
194439002151 N-terminal domain interface [polypeptide binding]; other site
194439002152 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
194439002153 binding surface
194439002154 TPR motif; other site
194439002155 TPR repeat; Region: TPR_11; pfam13414
194439002156 TPR repeat; Region: TPR_11; pfam13414
194439002157 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
194439002158 binding surface
194439002159 TPR motif; other site
194439002160 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
194439002161 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
194439002162 NADH dehydrogenase subunit B; Provisional; Region: PRK14813
194439002163 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
194439002164 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
194439002165 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
194439002166 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
194439002167 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
194439002168 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
194439002169 NADH-ubiquinone/plastoquinone oxidoreductase chain 6; Region: Oxidored_q3; cl17265
194439002170 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
194439002171 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
194439002172 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
194439002173 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
194439002174 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972
194439002175 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
194439002176 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
194439002177 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
194439002178 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
194439002179 Ni/Fe-hydrogenase, b-type cytochrome subunit; Region: CytB-hydogenase; TIGR02125
194439002180 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477
194439002181 nickel binding site [ion binding]; other site
194439002182 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642
194439002183 homodecamer interface [polypeptide binding]; other site
194439002184 active site
194439002185 putative catalytic site residues [active]
194439002186 zinc binding site [ion binding]; other site
194439002187 GTP-CH-I/GFRP interaction surface; other site
194439002188 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263
194439002189 active site
194439002190 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
194439002191 catalytic residues [active]
194439002192 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
194439002193 hydrogenase 1 large subunit; Provisional; Region: PRK10170
194439002194 Short C-terminal domain; Region: SHOCT; pfam09851
194439002195 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
194439002196 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
194439002197 FeS/SAM binding site; other site
194439002198 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
194439002199 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
194439002200 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
194439002201 dimer interface [polypeptide binding]; other site
194439002202 active site residues [active]
194439002203 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
194439002204 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
194439002205 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107
194439002206 Uncharacterized prokaryotic subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_eoslipins_u1; cd08826
194439002207 trimer interface [polypeptide binding]; other site
194439002208 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
194439002209 Ligand Binding Site [chemical binding]; other site
194439002210 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
194439002211 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
194439002212 Walker A; other site
194439002213 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172
194439002214 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
194439002215 B12 binding site [chemical binding]; other site
194439002216 cobalt ligand [ion binding]; other site
194439002217 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172
194439002218 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
194439002219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
194439002220 S-adenosylmethionine binding site [chemical binding]; other site
194439002221 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
194439002222 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
194439002223 PYR/PP interface [polypeptide binding]; other site
194439002224 dimer interface [polypeptide binding]; other site
194439002225 TPP binding site [chemical binding]; other site
194439002226 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
194439002227 hypothetical protein; Provisional; Region: PRK14621
194439002228 recombination protein RecR; Reviewed; Region: recR; PRK00076
194439002229 Helix-hairpin-helix motif; Region: HHH; pfam00633
194439002230 RecR protein; Region: RecR; pfam02132
194439002231 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
194439002232 putative active site [active]
194439002233 putative metal-binding site [ion binding]; other site
194439002234 tetramer interface [polypeptide binding]; other site
194439002235 phytoene desaturase; Region: phytoene_desat; TIGR02731
194439002236 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
194439002237 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
194439002238 ABC transporter signature motif; other site
194439002239 AAA domain; Region: AAA_21; pfam13304
194439002240 Walker B; other site
194439002241 D-loop; other site
194439002242 H-loop/switch region; other site
194439002243 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
194439002244 dimerization interface [polypeptide binding]; other site
194439002245 putative DNA binding site [nucleotide binding]; other site
194439002246 putative Zn2+ binding site [ion binding]; other site
194439002247 Predicted permeases [General function prediction only]; Region: COG0701
194439002248 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
194439002249 putative FMN binding site [chemical binding]; other site
194439002250 NADPH bind site [chemical binding]; other site
194439002251 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
194439002252 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
194439002253 metal-binding site [ion binding]
194439002254 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
194439002255 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
194439002256 Cytochrome C biogenesis protein transmembrane region; Region: DsbD_2; pfam13386
194439002257 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
194439002258 metal-binding site [ion binding]
194439002259 peptide chain release factor 3; Provisional; Region: prfC; PRK00741
194439002260 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
194439002261 G1 box; other site
194439002262 putative GEF interaction site [polypeptide binding]; other site
194439002263 GTP/Mg2+ binding site [chemical binding]; other site
194439002264 Switch I region; other site
194439002265 G2 box; other site
194439002266 G3 box; other site
194439002267 Switch II region; other site
194439002268 G4 box; other site
194439002269 G5 box; other site
194439002270 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
194439002271 Protein of unknown function (DUF3680); Region: DUF3680; pfam12441
194439002272 Protein of unknown function (DUF497); Region: DUF497; pfam04365
194439002273 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
194439002274 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
194439002275 substrate binding site [chemical binding]; other site
194439002276 metal binding sites [ion binding]; metal-binding site
194439002277 dimer interface [polypeptide binding]; other site
194439002278 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
194439002279 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
194439002280 NeuB family; Region: NeuB; pfam03102
194439002281 heat shock protein 90; Provisional; Region: PRK05218
194439002282 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
194439002283 ATP binding site [chemical binding]; other site
194439002284 Mg2+ binding site [ion binding]; other site
194439002285 G-X-G motif; other site
194439002286 Hsp90 protein; Region: HSP90; pfam00183
194439002287 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044
194439002288 diiron binding motif [ion binding]; other site
194439002289 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431
194439002290 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
194439002291 Predicted kinase [General function prediction only]; Region: COG0645
194439002292 AAA domain; Region: AAA_33; pfam13671
194439002293 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
194439002294 Fumarase C-terminus; Region: Fumerase_C; pfam05683
194439002295 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016
194439002296 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
194439002297 active site
194439002298 catalytic residues [active]
194439002299 metal binding site [ion binding]; metal-binding site
194439002300 homodimer binding site [polypeptide binding]; other site
194439002301 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
194439002302 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
194439002303 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
194439002304 carboxyltransferase (CT) interaction site; other site
194439002305 biotinylation site [posttranslational modification]; other site
194439002306 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
194439002307 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
194439002308 Leucine rich repeat; Region: LRR_8; pfam13855
194439002309 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
194439002310 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
194439002311 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
194439002312 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
194439002313 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
194439002314 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
194439002315 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
194439002316 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
194439002317 putative ADP-binding pocket [chemical binding]; other site
194439002318 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
194439002319 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
194439002320 active site
194439002321 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
194439002322 Helix-hairpin-helix motif; Region: HHH_6; pfam14579
194439002323 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
194439002324 generic binding surface II; other site
194439002325 generic binding surface I; other site
194439002326 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
194439002327 catalytic residues [active]
194439002328 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
194439002329 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
194439002330 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
194439002331 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
194439002332 active site residue [active]
194439002333 Predicted membrane protein [Function unknown]; Region: COG2855
194439002334 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
194439002335 CPxP motif; other site
194439002336 DsrC like protein; Region: DsrC; pfam04358
194439002337 sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064
194439002338 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
194439002339 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
194439002340 sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066
194439002341 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
194439002342 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
194439002343 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
194439002344 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
194439002345 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
194439002346 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
194439002347 NAD binding site [chemical binding]; other site
194439002348 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
194439002349 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
194439002350 sulfur relay protein TusD/DsrE; Region: sulf_tusD_dsrE; TIGR03012
194439002351 sulfur relay protein TusC/DsrF; Region: sulf_tusC_dsrF; TIGR03010
194439002352 sulfur relay protein TusB/DsrH; Region: sulf_tusB_dsrH; TIGR03011
194439002353 Sulfite exporter TauE/SafE; Region: TauE; pfam01925
194439002354 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
194439002355 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
194439002356 ATP-sulfurylase; Region: ATPS; cd00517
194439002357 active site
194439002358 HXXH motif; other site
194439002359 flexible loop; other site
194439002360 adenosine phosphosulphate reductase, beta subunit; Region: aprB; TIGR02060
194439002361 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
194439002362 Adenosine-5'-phosphosulfate reductase beta subunit; Region: APS-reductase_C; pfam12139
194439002363 adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854
194439002364 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
194439002365 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
194439002366 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
194439002367 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
194439002368 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
194439002369 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
194439002370 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
194439002371 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
194439002372 CitB domain protein; Region: CitB; TIGR02484
194439002373 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
194439002374 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
194439002375 Putative zinc- or iron-chelating domain; Region: CxxCxxCC; pfam03692
194439002376 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; Region: ACP_syn_III; pfam08545
194439002377 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
194439002378 UbiA family of prenyltransferases (PTases); Region: PT_UbiA; cl00337
194439002379 Transposase, Mutator family; Region: Transposase_mut; cl19537
194439002380 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
194439002381 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
194439002382 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
194439002383 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
194439002384 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
194439002385 putative active site [active]
194439002386 putative metal binding site [ion binding]; other site
194439002387 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
194439002388 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
194439002389 P-loop; other site
194439002390 Magnesium ion binding site [ion binding]; other site
194439002391 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
194439002392 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387
194439002393 polyphosphate kinase; Provisional; Region: PRK05443
194439002394 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
194439002395 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
194439002396 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
194439002397 putative domain interface [polypeptide binding]; other site
194439002398 putative active site [active]
194439002399 catalytic site [active]
194439002400 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
194439002401 putative domain interface [polypeptide binding]; other site
194439002402 putative active site [active]
194439002403 catalytic site [active]
194439002404 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
194439002405 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
194439002406 active site
194439002407 motif I; other site
194439002408 motif II; other site
194439002409 Methyltransferase domain; Region: Methyltransf_31; pfam13847
194439002410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
194439002411 S-adenosylmethionine binding site [chemical binding]; other site
194439002412 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
194439002413 putative acyl-acceptor binding pocket; other site
194439002414 phosphate binding protein; Region: ptsS_2; TIGR02136
194439002415 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131
194439002416 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
194439002417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
194439002418 dimer interface [polypeptide binding]; other site
194439002419 conserved gate region; other site
194439002420 putative PBP binding loops; other site
194439002421 ABC-ATPase subunit interface; other site
194439002422 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
194439002423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
194439002424 dimer interface [polypeptide binding]; other site
194439002425 conserved gate region; other site
194439002426 putative PBP binding loops; other site
194439002427 ABC-ATPase subunit interface; other site
194439002428 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14275
194439002429 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
194439002430 Walker A/P-loop; other site
194439002431 ATP binding site [chemical binding]; other site
194439002432 Q-loop/lid; other site
194439002433 ABC transporter signature motif; other site
194439002434 Walker B; other site
194439002435 D-loop; other site
194439002436 H-loop/switch region; other site
194439002437 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
194439002438 PhoU domain; Region: PhoU; pfam01895
194439002439 PhoU domain; Region: PhoU; pfam01895
194439002440 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322
194439002441 PhoU domain; Region: PhoU; pfam01895
194439002442 PhoU domain; Region: PhoU; pfam01895
194439002443 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311
194439002444 putative active site [active]
194439002445 catalytic site [active]
194439002446 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
194439002447 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
194439002448 ATP binding site [chemical binding]; other site
194439002449 putative Mg++ binding site [ion binding]; other site
194439002450 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
194439002451 nucleotide binding region [chemical binding]; other site
194439002452 ATP-binding site [chemical binding]; other site
194439002453 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335
194439002454 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
194439002455 DNA methylase; Region: N6_N4_Mtase; pfam01555
194439002456 Predicted ATPase [General function prediction only]; Region: COG4637
194439002457 AAA domain; Region: AAA_23; pfam13476
194439002458 Walker A/P-loop; other site
194439002459 ATP binding site [chemical binding]; other site
194439002460 AAA domain; Region: AAA_21; pfam13304
194439002461 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
194439002462 Restriction endonuclease [Defense mechanisms]; Region: COG3587
194439002463 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
194439002464 ATP binding site [chemical binding]; other site
194439002465 putative Mg++ binding site [ion binding]; other site
194439002466 CbiD; Region: CbiD; cl00828
194439002467 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
194439002468 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
194439002469 non-specific DNA binding site [nucleotide binding]; other site
194439002470 salt bridge; other site
194439002471 sequence-specific DNA binding site [nucleotide binding]; other site
194439002472 DoxX-like family; Region: DoxX_3; pfam13781
194439002473 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
194439002474 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
194439002475 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
194439002476 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
194439002477 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
194439002478 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
194439002479 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
194439002480 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
194439002481 active site
194439002482 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
194439002483 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
194439002484 NAD(P) binding site [chemical binding]; other site
194439002485 active site
194439002486 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
194439002487 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
194439002488 amino acid transporter; Region: 2A0306; TIGR00909
194439002489 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
194439002490 C-terminus of AA_permease; Region: AA_permease_C; pfam13906
194439002491 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172
194439002492 AAA domain; Region: AAA_28; pfam13521
194439002493 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
194439002494 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
194439002495 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
194439002496 catalytic triad [active]
194439002497 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
194439002498 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
194439002499 cobalamin binding residues [chemical binding]; other site
194439002500 putative BtuC binding residues; other site
194439002501 dimer interface [polypeptide binding]; other site
194439002502 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
194439002503 nudix motif; other site
194439002504 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
194439002505 putative hydrophobic ligand binding site [chemical binding]; other site
194439002506 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
194439002507 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
194439002508 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
194439002509 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
194439002510 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
194439002511 N-terminal plug; other site
194439002512 ligand-binding site [chemical binding]; other site
194439002513 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
194439002514 intersubunit interface [polypeptide binding]; other site
194439002515 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
194439002516 putative FMN binding site [chemical binding]; other site
194439002517 cobyric acid synthase; Provisional; Region: PRK00784
194439002518 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
194439002519 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
194439002520 catalytic triad [active]
194439002521 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
194439002522 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
194439002523 pyridoxal 5'-phosphate binding site [chemical binding]; other site
194439002524 homodimer interface [polypeptide binding]; other site
194439002525 catalytic residue [active]
194439002526 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
194439002527 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572
194439002528 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
194439002529 ABC-ATPase subunit interface; other site
194439002530 dimer interface [polypeptide binding]; other site
194439002531 putative PBP binding regions; other site
194439002532 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
194439002533 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
194439002534 Walker A/P-loop; other site
194439002535 ATP binding site [chemical binding]; other site
194439002536 Q-loop/lid; other site
194439002537 ABC transporter signature motif; other site
194439002538 Walker B; other site
194439002539 D-loop; other site
194439002540 H-loop/switch region; other site
194439002541 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
194439002542 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
194439002543 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
194439002544 homotrimer interface [polypeptide binding]; other site
194439002545 Walker A motif; other site
194439002546 GTP binding site [chemical binding]; other site
194439002547 Walker B motif; other site
194439002548 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
194439002549 putative dimer interface [polypeptide binding]; other site
194439002550 active site pocket [active]
194439002551 putative cataytic base [active]
194439002552 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
194439002553 Putative lysophospholipase; Region: Hydrolase_4; cl19140
194439002554 cobalamin synthase; Reviewed; Region: cobS; PRK00235
194439002555 OsmC-like protein; Region: OsmC; pfam02566
194439002556 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
194439002557 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
194439002558 DNA binding residues [nucleotide binding]
194439002559 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183
194439002560 putative active site [active]
194439002561 metal binding site [ion binding]; metal-binding site
194439002562 SET domain; Region: SET; pfam00856
194439002563 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
194439002564 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
194439002565 Walker A/P-loop; other site
194439002566 ATP binding site [chemical binding]; other site
194439002567 Q-loop/lid; other site
194439002568 ABC transporter signature motif; other site
194439002569 Walker B; other site
194439002570 D-loop; other site
194439002571 H-loop/switch region; other site
194439002572 Integrase core domain; Region: rve_3; cl15866
194439002573 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
194439002574 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
194439002575 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
194439002576 putative catalytic site [active]
194439002577 putative metal binding site [ion binding]; other site
194439002578 putative phosphate binding site [ion binding]; other site
194439002579 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
194439002580 Sel1-like repeats; Region: SEL1; smart00671
194439002581 Sel1-like repeats; Region: SEL1; smart00671
194439002582 Sel1-like repeats; Region: SEL1; smart00671
194439002583 Sel1-like repeats; Region: SEL1; smart00671
194439002584 Sel1-like repeats; Region: SEL1; smart00671
194439002585 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
194439002586 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
194439002587 ATP binding site [chemical binding]; other site
194439002588 active site
194439002589 substrate binding site [chemical binding]; other site
194439002590 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
194439002591 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
194439002592 TPP-binding site [chemical binding]; other site
194439002593 dimer interface [polypeptide binding]; other site
194439002594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
194439002595 S-adenosylmethionine binding site [chemical binding]; other site
194439002596 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
194439002597 active site
194439002598 (T/H)XGH motif; other site
194439002599 aspartate aminotransferase; Provisional; Region: PRK05764
194439002600 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
194439002601 pyridoxal 5'-phosphate binding site [chemical binding]; other site
194439002602 homodimer interface [polypeptide binding]; other site
194439002603 catalytic residue [active]
194439002604 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551
194439002605 putative acyl-acceptor binding pocket; other site
194439002606 PSP1 C-terminal conserved region; Region: PSP1; pfam04468
194439002607 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
194439002608 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
194439002609 active site
194439002610 HIGH motif; other site
194439002611 KMSKS motif; other site
194439002612 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
194439002613 tRNA binding surface [nucleotide binding]; other site
194439002614 anticodon binding site; other site
194439002615 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
194439002616 dimer interface [polypeptide binding]; other site
194439002617 putative tRNA-binding site [nucleotide binding]; other site
194439002618 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
194439002619 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
194439002620 anti sigma factor interaction site; other site
194439002621 regulatory phosphorylation site [posttranslational modification]; other site
194439002622 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
194439002623 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
194439002624 active site
194439002625 dimer interface [polypeptide binding]; other site
194439002626 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477
194439002627 Na binding site [ion binding]; other site
194439002628 Ribokinase-like subgroup C. Found only in bacteria, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_C; cd01946
194439002629 substrate binding site [chemical binding]; other site
194439002630 ATP binding site [chemical binding]; other site
194439002631 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
194439002632 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128
194439002633 active site
194439002634 catalytic site [active]
194439002635 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
194439002636 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570
194439002637 dimerization interface 3.5A [polypeptide binding]; other site
194439002638 active site
194439002639 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254
194439002640 N-acetyl-D-glucosamine binding site [chemical binding]; other site
194439002641 catalytic residue [active]
194439002642 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
194439002643 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
194439002644 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
194439002645 P loop; other site
194439002646 Nucleotide binding site [chemical binding]; other site
194439002647 DTAP/Switch II; other site
194439002648 Switch I; other site
194439002649 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
194439002650 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
194439002651 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
194439002652 Nitrogen regulatory protein P-II; Region: P-II; pfam00543
194439002653 Ammonium Transporter Family; Region: Ammonium_transp; cl03012
194439002654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
194439002655 ATP binding site [chemical binding]; other site
194439002656 Mg2+ binding site [ion binding]; other site
194439002657 G-X-G motif; other site
194439002658 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
194439002659 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
194439002660 active site
194439002661 dimer interface [polypeptide binding]; other site
194439002662 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
194439002663 dimer interface [polypeptide binding]; other site
194439002664 active site
194439002665 adenylosuccinate lyase; Provisional; Region: PRK07492
194439002666 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
194439002667 tetramer interface [polypeptide binding]; other site
194439002668 active site
194439002669 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
194439002670 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
194439002671 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
194439002672 active site
194439002673 NTP binding site [chemical binding]; other site
194439002674 metal binding triad [ion binding]; metal-binding site
194439002675 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
194439002676 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
194439002677 Zn2+ binding site [ion binding]; other site
194439002678 Mg2+ binding site [ion binding]; other site
194439002679 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
194439002680 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
194439002681 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
194439002682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
194439002683 Major Facilitator Superfamily; Region: MFS_1; pfam07690
194439002684 putative substrate translocation pore; other site
194439002685 Predicted ATPase [General function prediction only]; Region: COG4637
194439002686 AAA domain; Region: AAA_23; pfam13476
194439002687 Walker A/P-loop; other site
194439002688 ATP binding site [chemical binding]; other site
194439002689 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
194439002690 ABC transporter signature motif; other site
194439002691 Walker B; other site
194439002692 D-loop; other site
194439002693 H-loop/switch region; other site
194439002694 Protein of unknown function (DUF4435); Region: DUF4435; pfam14491
194439002695 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
194439002696 nucleoside/Zn binding site; other site
194439002697 dimer interface [polypeptide binding]; other site
194439002698 catalytic motif [active]
194439002699 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
194439002700 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
194439002701 NAD(P) binding site [chemical binding]; other site
194439002702 putative active site [active]
194439002703 8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588
194439002704 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934
194439002705 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
194439002706 minor groove reading motif; other site
194439002707 helix-hairpin-helix signature motif; other site
194439002708 substrate binding pocket [chemical binding]; other site
194439002709 active site
194439002710 PemK-like protein; Region: PemK; pfam02452
194439002711 RNB domain; Region: RNB; pfam00773
194439002712 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
194439002713 RNA binding site [nucleotide binding]; other site
194439002714 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
194439002715 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
194439002716 PhnA protein; Region: PhnA; pfam03831
194439002717 DsrE/DsrF-like family; Region: DrsE; cl00672
194439002718 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
194439002719 High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I...; Region: HMG-box; cl00082
194439002720 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
194439002721 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
194439002722 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
194439002723 Ligand Binding Site [chemical binding]; other site
194439002724 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
194439002725 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
194439002726 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
194439002727 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
194439002728 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
194439002729 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
194439002730 Cytochrome c [Energy production and conversion]; Region: COG3258
194439002731 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
194439002732 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411
194439002733 active site
194439002734 metal binding site [ion binding]; metal-binding site
194439002735 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
194439002736 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
194439002737 catalytic residues [active]
194439002738 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
194439002739 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
194439002740 alternate F1F0 ATPase, F0 subunit A; Region: altF1_A; TIGR03306
194439002741 F1/F0 ATPase, Methanosarcina type, subunit 2; Region: F1F0_chp_2; TIGR03165
194439002742 F0F1-ATPase subunit, putative; Region: ATPase_gene1; TIGR02230
194439002743 F0F1 ATP synthase subunit epsilon; Validated; Region: PRK06228
194439002744 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
194439002745 gamma subunit interface [polypeptide binding]; other site
194439002746 epsilon subunit interface [polypeptide binding]; other site
194439002747 LBP interface [polypeptide binding]; other site
194439002748 alternate F1F0 ATPase, F1 subunit beta; Region: alt_F1F0_F1_bet; TIGR03305
194439002749 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
194439002750 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
194439002751 alpha subunit interaction interface [polypeptide binding]; other site
194439002752 Walker A motif; other site
194439002753 ATP binding site [chemical binding]; other site
194439002754 Walker B motif; other site
194439002755 inhibitor binding site; inhibition site
194439002756 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
194439002757 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
194439002758 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268
194439002759 ATP binding site [chemical binding]; other site
194439002760 Mg++ binding site [ion binding]; other site
194439002761 motif III; other site
194439002762 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
194439002763 nucleotide binding region [chemical binding]; other site
194439002764 ATP-binding site [chemical binding]; other site
194439002765 Domain of unknown function (DUF373); Region: DUF373; cl12079
194439002766 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
194439002767 ligand binding site [chemical binding]; other site
194439002768 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
194439002769 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
194439002770 putative NADP binding site [chemical binding]; other site
194439002771 putative substrate binding site [chemical binding]; other site
194439002772 active site
194439002773 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
194439002774 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
194439002775 ligand binding site [chemical binding]; other site
194439002776 flexible hinge region; other site
194439002777 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
194439002778 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
194439002779 metal binding triad; other site
194439002780 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335
194439002781 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
194439002782 active site
194439002783 catalytic site [active]
194439002784 substrate binding site [chemical binding]; other site
194439002785 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
194439002786 S-adenosylmethionine binding site [chemical binding]; other site
194439002787 dihydroorotase; Validated; Region: pyrC; PRK09357
194439002788 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
194439002789 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
194439002790 active site
194439002791 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
194439002792 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
194439002793 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
194439002794 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
194439002795 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
194439002796 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
194439002797 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
194439002798 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
194439002799 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
194439002800 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
194439002801 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
194439002802 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
194439002803 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
194439002804 TIR domain; Region: TIR_2; pfam13676
194439002805 putative minor structural protein; Region: PHA01351
194439002806 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
194439002807 polyphosphate kinase; Provisional; Region: PRK05443
194439002808 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
194439002809 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
194439002810 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
194439002811 putative domain interface [polypeptide binding]; other site
194439002812 putative active site [active]
194439002813 catalytic site [active]
194439002814 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
194439002815 putative domain interface [polypeptide binding]; other site
194439002816 putative active site [active]
194439002817 catalytic site [active]
194439002818 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
194439002819 FOG: CBS domain [General function prediction only]; Region: COG0517
194439002820 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
194439002821 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
194439002822 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
194439002823 metal binding site [ion binding]; metal-binding site
194439002824 dimer interface [polypeptide binding]; other site
194439002825 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
194439002826 intersubunit interface [polypeptide binding]; other site
194439002827 active site
194439002828 zinc binding site [ion binding]; other site
194439002829 Na+ binding site [ion binding]; other site
194439002830 carboxy-terminal protease; Provisional; Region: PRK11186
194439002831 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
194439002832 protein binding site [polypeptide binding]; other site
194439002833 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
194439002834 Catalytic dyad [active]
194439002835 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
194439002836 argininosuccinate lyase; Provisional; Region: PRK00855
194439002837 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
194439002838 active sites [active]
194439002839 tetramer interface [polypeptide binding]; other site
194439002840 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
194439002841 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
194439002842 metal binding site [ion binding]; metal-binding site
194439002843 dimer interface [polypeptide binding]; other site
194439002844 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
194439002845 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
194439002846 nucleotidyl binding site; other site
194439002847 metal binding site [ion binding]; metal-binding site
194439002848 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
194439002849 ATP-grasp domain; Region: ATP-grasp; pfam02222
194439002850 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866
194439002851 putative hydrophobic ligand binding site [chemical binding]; other site
194439002852 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
194439002853 Ycf39; Provisional; Region: ycf39; CHL00194
194439002854 NAD(P) binding site [chemical binding]; other site
194439002855 putative active site [active]
194439002856 TIGR02453 family protein; Region: TIGR02453
194439002857 yecA family protein; Region: ygfB_yecA; TIGR02292
194439002858 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
194439002859 non-specific DNA interactions [nucleotide binding]; other site
194439002860 DNA binding site [nucleotide binding]
194439002861 sequence specific DNA binding site [nucleotide binding]; other site
194439002862 putative cAMP binding site [chemical binding]; other site
194439002863 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
194439002864 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
194439002865 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
194439002866 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
194439002867 AAA domain; Region: AAA_30; pfam13604
194439002868 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
194439002869 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
194439002870 catalytic residues [active]
194439002871 Protein of unknown function (DUF3570); Region: DUF3570; pfam12094
194439002872 ApbE family; Region: ApbE; pfam02424
194439002873 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
194439002874 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
194439002875 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
194439002876 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
194439002877 DsbD alpha interface [polypeptide binding]; other site
194439002878 catalytic residues [active]
194439002879 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
194439002880 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
194439002881 NAD(P) binding site [chemical binding]; other site
194439002882 putative active site [active]
194439002883 lipoyl synthase; Provisional; Region: PRK05481
194439002884 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
194439002885 FeS/SAM binding site; other site
194439002886 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
194439002887 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
194439002888 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
194439002889 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
194439002890 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
194439002891 NAD(P) binding site [chemical binding]; other site
194439002892 active site
194439002893 phosphate acetyltransferase; Provisional; Region: PRK11890
194439002894 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
194439002895 CoA binding domain; Region: CoA_binding; smart00881
194439002896 ATP citrate (pro-S)-lyase; Region: PLN02522
194439002897 CoA-ligase; Region: Ligase_CoA; pfam00549
194439002898 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100
194439002899 active site
194439002900 oxalacetate binding site [chemical binding]; other site
194439002901 citrylCoA binding site [chemical binding]; other site
194439002902 coenzyme A binding site [chemical binding]; other site
194439002903 catalytic triad [active]
194439002904 Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045
194439002905 ATP-grasp domain; Region: ATP-grasp_2; pfam08442
194439002906 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
194439002907 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
194439002908 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
194439002909 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
194439002910 Walker A/P-loop; other site
194439002911 ATP binding site [chemical binding]; other site
194439002912 Q-loop/lid; other site
194439002913 ABC transporter signature motif; other site
194439002914 Walker B; other site
194439002915 D-loop; other site
194439002916 H-loop/switch region; other site
194439002917 Domain of unknown function DUF87; Region: DUF87; cl19135
194439002918 AAA-like domain; Region: AAA_10; pfam12846
194439002919 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
194439002920 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111
194439002921 Predicted membrane protein [Function unknown]; Region: COG2119
194439002922 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
194439002923 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
194439002924 Lipocalin-like domain; Region: Lipocalin_2; cl19222
194439002925 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
194439002926 Acetyltransferases [General function prediction only]; Region: RimI; COG0456
194439002927 Coenzyme A binding pocket [chemical binding]; other site
194439002928 Rubredoxin [Energy production and conversion]; Region: COG1773
194439002929 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
194439002930 iron binding site [ion binding]; other site
194439002931 Rubredoxin [Energy production and conversion]; Region: COG1773
194439002932 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
194439002933 iron binding site [ion binding]; other site
194439002934 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
194439002935 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
194439002936 FtsX-like permease family; Region: FtsX; pfam02687
194439002937 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
194439002938 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
194439002939 FtsX-like permease family; Region: FtsX; pfam02687
194439002940 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
194439002941 metal binding site [ion binding]; metal-binding site
194439002942 active site
194439002943 I-site; other site
194439002944 PBP superfamily domain; Region: PBP_like_2; pfam12849
194439002945 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
194439002946 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
194439002947 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl19935
194439002948 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
194439002949 heterotetramer interface [polypeptide binding]; other site
194439002950 active site pocket [active]
194439002951 cleavage site
194439002952 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
194439002953 feedback inhibition sensing region; other site
194439002954 homohexameric interface [polypeptide binding]; other site
194439002955 nucleotide binding site [chemical binding]; other site
194439002956 N-acetyl-L-glutamate binding site [chemical binding]; other site
194439002957 ornithine carbamoyltransferase; Provisional; Region: PRK00779
194439002958 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
194439002959 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
194439002960 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
194439002961 arginine repressor; Provisional; Region: PRK04280
194439002962 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
194439002963 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999
194439002964 ANP binding site [chemical binding]; other site
194439002965 Substrate Binding Site II [chemical binding]; other site
194439002966 Substrate Binding Site I [chemical binding]; other site
194439002967 Amidohydrolase; Region: Amidohydro_2; pfam04909
194439002968 SOUL heme-binding protein; Region: SOUL; pfam04832
194439002969 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
194439002970 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721
194439002971 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637
194439002972 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689
194439002973 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09642
194439002974 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752
194439002975 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
194439002976 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639
194439002977 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
194439002978 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447
194439002979 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
194439002980 FAD binding domain; Region: FAD_binding_4; pfam01565
194439002981 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
194439002982 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
194439002983 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
194439002984 Cysteine-rich domain; Region: CCG; pfam02754
194439002985 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
194439002986 classical (c) SDRs; Region: SDR_c; cd05233
194439002987 NAD(P) binding site [chemical binding]; other site
194439002988 active site
194439002989 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
194439002990 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
194439002991 Ligand Binding Site [chemical binding]; other site
194439002992 NlpC/P60 family; Region: NLPC_P60; pfam00877
194439002993 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
194439002994 putative active site [active]
194439002995 exonuclease subunit SbcC; Provisional; Region: PRK10246
194439002996 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
194439002997 Walker A/P-loop; other site
194439002998 ATP binding site [chemical binding]; other site
194439002999 Q-loop/lid; other site
194439003000 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
194439003001 ABC transporter signature motif; other site
194439003002 Walker B; other site
194439003003 D-loop; other site
194439003004 H-loop/switch region; other site
194439003005 exonuclease subunit SbcD; Provisional; Region: PRK10966
194439003006 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
194439003007 active site
194439003008 metal binding site [ion binding]; metal-binding site
194439003009 DNA binding site [nucleotide binding]
194439003010 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
194439003011 RmuC family; Region: RmuC; pfam02646
194439003012 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
194439003013 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
194439003014 Nitroreductase family. Members of this family utilize FMN as a cofactor. This family is involved in the reduction of flavin or nitroaromatic compounds by using NAD(P)H as electron donor in a obligatory two-electron transfer. Nitrogenase is homodimer; Region: NADH_nitroreductase; cd02143
194439003015 putative FMN binding site [chemical binding]; other site
194439003016 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
194439003017 inhibitor-cofactor binding pocket; inhibition site
194439003018 pyridoxal 5'-phosphate binding site [chemical binding]; other site
194439003019 catalytic residue [active]
194439003020 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
194439003021 active site
194439003022 NAD binding site [chemical binding]; other site
194439003023 metal binding site [ion binding]; metal-binding site
194439003024 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
194439003025 ligand binding site; other site
194439003026 tetramer interface; other site
194439003027 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
194439003028 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
194439003029 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
194439003030 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
194439003031 acyl-activating enzyme (AAE) consensus motif; other site
194439003032 putative AMP binding site [chemical binding]; other site
194439003033 putative active site [active]
194439003034 putative CoA binding site [chemical binding]; other site
194439003035 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
194439003036 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
194439003037 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777
194439003038 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
194439003039 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
194439003040 This entry represents the putative helicase A859L; Region: T5orf172; smart00974
194439003041 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
194439003042 minor groove reading motif; other site
194439003043 helix-hairpin-helix signature motif; other site
194439003044 substrate binding pocket [chemical binding]; other site
194439003045 active site
194439003046 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
194439003047 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
194439003048 16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273
194439003049 RimM N-terminal domain; Region: RimM; pfam01782
194439003050 PRC-barrel domain; Region: PRC; pfam05239
194439003051 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
194439003052 signal recognition particle protein; Provisional; Region: PRK10867
194439003053 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
194439003054 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
194439003055 P loop; other site
194439003056 GTP binding site [chemical binding]; other site
194439003057 Signal peptide binding domain; Region: SRP_SPB; pfam02978
194439003058 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
194439003059 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
194439003060 putative ribose interaction site [chemical binding]; other site
194439003061 putative ADP binding site [chemical binding]; other site
194439003062 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876
194439003063 putative lipid binding site [chemical binding]; other site
194439003064 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
194439003065 hydrophobic ligand binding site; other site
194439003066 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
194439003067 C-terminal peptidase (prc); Region: prc; TIGR00225
194439003068 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
194439003069 protein binding site [polypeptide binding]; other site
194439003070 Catalytic dyad [active]
194439003071 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
194439003072 homotrimer interaction site [polypeptide binding]; other site
194439003073 putative active site [active]
194439003074 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
194439003075 active site
194439003076 thiamine phosphate binding site [chemical binding]; other site
194439003077 pyrophosphate binding site [ion binding]; other site
194439003078 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
194439003079 thiamine phosphate binding site [chemical binding]; other site
194439003080 active site
194439003081 pyrophosphate binding site [ion binding]; other site
194439003082 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
194439003083 dimer interface [polypeptide binding]; other site
194439003084 substrate binding site [chemical binding]; other site
194439003085 ATP binding site [chemical binding]; other site
194439003086 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
194439003087 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721
194439003088 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
194439003089 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
194439003090 Biogenesis of lysosome-related organelles complex-1 subunit 2; Region: BLOC1_2; pfam10046
194439003091 multifunctional aminopeptidase A; Provisional; Region: PRK00913
194439003092 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
194439003093 interface (dimer of trimers) [polypeptide binding]; other site
194439003094 Substrate-binding/catalytic site; other site
194439003095 Zn-binding sites [ion binding]; other site
194439003096 DHH family; Region: DHH; pfam01368
194439003097 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
194439003098 DHHA1 domain; Region: DHHA1; pfam02272
194439003099 Winged helix DNA-binding domain; Region: HTH_34; pfam13601
194439003100 Transcriptional regulators [Transcription]; Region: MarR; COG1846
194439003101 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14456
194439003102 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
194439003103 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
194439003104 FeS/SAM binding site; other site
194439003105 adenylate kinase; Reviewed; Region: adk; PRK00279
194439003106 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
194439003107 AMP-binding site [chemical binding]; other site
194439003108 ATP-AMP (Ap5A)-binding site [chemical binding]; other site
194439003109 primosome assembly protein PriA; Validated; Region: PRK05580
194439003110 Helix-turn-helix domain; Region: HTH_20; pfam12840
194439003111 putative DNA binding site [nucleotide binding]; other site
194439003112 putative Zn2+ binding site [ion binding]; other site
194439003113 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
194439003114 ATP binding site [chemical binding]; other site
194439003115 putative Mg++ binding site [ion binding]; other site
194439003116 helicase superfamily c-terminal domain; Region: HELICc; smart00490
194439003117 DoxX; Region: DoxX; pfam07681
194439003118 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
194439003119 TPR motif; other site
194439003120 binding surface
194439003121 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
194439003122 trimer interface [polypeptide binding]; other site
194439003123 active site
194439003124 dimer interface [polypeptide binding]; other site
194439003125 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
194439003126 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
194439003127 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
194439003128 Walker A motif; other site
194439003129 ATP binding site [chemical binding]; other site
194439003130 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
194439003131 Walker B motif; other site
194439003132 arginine finger; other site
194439003133 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
194439003134 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
194439003135 active site
194439003136 HslU subunit interaction site [polypeptide binding]; other site
194439003137 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
194439003138 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
194439003139 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
194439003140 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307
194439003141 DNA repair protein RadA; Provisional; Region: PRK11823
194439003142 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
194439003143 Walker A motif/ATP binding site; other site
194439003144 ATP binding site [chemical binding]; other site
194439003145 Walker B motif; other site
194439003146 Membrane protein of unknown function; Region: DUF360; pfam04020
194439003147 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202
194439003148 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
194439003149 putative NAD(P) binding site [chemical binding]; other site
194439003150 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
194439003151 TM-ABC transporter signature motif; other site
194439003152 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
194439003153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
194439003154 S-adenosylmethionine binding site [chemical binding]; other site
194439003155 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
194439003156 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
194439003157 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
194439003158 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
194439003159 substrate binding pocket [chemical binding]; other site
194439003160 chain length determination region; other site
194439003161 substrate-Mg2+ binding site; other site
194439003162 catalytic residues [active]
194439003163 aspartate-rich region 1; other site
194439003164 active site lid residues [active]
194439003165 aspartate-rich region 2; other site
194439003166 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902
194439003167 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187
194439003168 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
194439003169 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
194439003170 CoA-binding site [chemical binding]; other site
194439003171 ATP-binding [chemical binding]; other site
194439003172 Domain of unknown function (DUF4296); Region: DUF4296; pfam14129
194439003173 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
194439003174 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
194439003175 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
194439003176 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125
194439003177 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
194439003178 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
194439003179 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
194439003180 putative RNA binding site [nucleotide binding]; other site
194439003181 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
194439003182 S-adenosylmethionine binding site [chemical binding]; other site
194439003183 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; pfam06941
194439003184 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
194439003185 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
194439003186 Tetratricopeptide repeat; Region: TPR_20; pfam14561
194439003187 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
194439003188 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
194439003189 flavoprotein, HI0933 family; Region: TIGR00275
194439003190 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
194439003191 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
194439003192 HlyD family secretion protein; Region: HlyD_3; pfam13437
194439003193 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
194439003194 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
194439003195 FtsX-like permease family; Region: FtsX; pfam02687
194439003196 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
194439003197 FtsX-like permease family; Region: FtsX; pfam02687
194439003198 N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510
194439003199 amidase catalytic site [active]
194439003200 Zn binding residues [ion binding]; other site
194439003201 substrate binding site [chemical binding]; other site
194439003202 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
194439003203 FAD binding domain; Region: FAD_binding_4; pfam01565
194439003204 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
194439003205 Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627
194439003206 putative heme binding site [chemical binding]; other site
194439003207 Transposase, Mutator family; Region: Transposase_mut; cl19537
194439003208 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
194439003209 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
194439003210 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
194439003211 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
194439003212 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
194439003213 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
194439003214 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
194439003215 motif II; other site
194439003216 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
194439003217 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12900
194439003218 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
194439003219 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
194439003220 nucleotide binding region [chemical binding]; other site
194439003221 ATP-binding site [chemical binding]; other site
194439003222 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516
194439003223 SEC-C motif; Region: SEC-C; cl19389
194439003224 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
194439003225 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
194439003226 dimerization interface [polypeptide binding]; other site
194439003227 ATP binding site [chemical binding]; other site
194439003228 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
194439003229 dimerization interface [polypeptide binding]; other site
194439003230 ATP binding site [chemical binding]; other site
194439003231 Uncharacterized conserved protein [Function unknown]; Region: COG0062
194439003232 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
194439003233 putative substrate binding site [chemical binding]; other site
194439003234 putative ATP binding site [chemical binding]; other site
194439003235 aminotransferase; Validated; Region: PRK08175
194439003236 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
194439003237 pyridoxal 5'-phosphate binding site [chemical binding]; other site
194439003238 homodimer interface [polypeptide binding]; other site
194439003239 catalytic residue [active]
194439003240 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
194439003241 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
194439003242 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
194439003243 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
194439003244 Cysteine-rich domain; Region: CCG; pfam02754
194439003245 Cysteine-rich domain; Region: CCG; pfam02754
194439003246 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
194439003247 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
194439003248 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
194439003249 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
194439003250 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
194439003251 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
194439003252 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
194439003253 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
194439003254 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345
194439003255 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
194439003256 FAD binding pocket [chemical binding]; other site
194439003257 FAD binding motif [chemical binding]; other site
194439003258 phosphate binding motif [ion binding]; other site
194439003259 beta-alpha-beta structure motif; other site
194439003260 NAD binding pocket [chemical binding]; other site
194439003261 Iron coordination center [ion binding]; other site
194439003262 Protein Kinases, catalytic domain; Region: PKc_like; cl09925
194439003263 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
194439003264 putative active site [active]
194439003265 catalytic residue [active]
194439003266 Putative lysophospholipase; Region: Hydrolase_4; cl19140
194439003267 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
194439003268 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
194439003269 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
194439003270 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
194439003271 pyridoxal 5'-phosphate binding site [chemical binding]; other site
194439003272 homodimer interface [polypeptide binding]; other site
194439003273 catalytic residue [active]
194439003274 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
194439003275 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
194439003276 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
194439003277 NADP binding site [chemical binding]; other site
194439003278 homopentamer interface [polypeptide binding]; other site
194439003279 substrate binding site [chemical binding]; other site
194439003280 active site
194439003281 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
194439003282 PhoH-like protein; Region: PhoH; pfam02562
194439003283 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224
194439003284 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224
194439003285 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
194439003286 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
194439003287 active site
194439003288 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
194439003289 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191
194439003290 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
194439003291 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
194439003292 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
194439003293 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
194439003294 Coenzyme A binding pocket [chemical binding]; other site
194439003295 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
194439003296 Bacteriochlorophyll/chlorophyll synthetase; Region: PT_UbiA_chlorophyll; cd13958
194439003297 putative active site [active]
194439003298 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
194439003299 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
194439003300 active site
194439003301 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695
194439003302 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
194439003303 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
194439003304 putative NAD(P) binding site [chemical binding]; other site
194439003305 putative substrate binding site [chemical binding]; other site
194439003306 catalytic Zn binding site [ion binding]; other site
194439003307 structural Zn binding site [ion binding]; other site
194439003308 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
194439003309 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
194439003310 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
194439003311 DNA binding residues [nucleotide binding]
194439003312 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550
194439003313 SelR domain; Region: SelR; cl15841
194439003314 methionine sulfoxide reductase A; Provisional; Region: PRK14054
194439003315 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
194439003316 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
194439003317 catalytic residues [active]
194439003318 Domain of unknown function (DUF4410); Region: DUF4410; pfam14366
194439003319 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822
194439003320 putative hydrophobic ligand binding site [chemical binding]; other site
194439003321 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
194439003322 Outer membrane efflux protein; Region: OEP; pfam02321
194439003323 Outer membrane efflux protein; Region: OEP; pfam02321
194439003324 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
194439003325 Inorganic H+ pyrophosphatase; Region: H_PPase; cl11452
194439003326 MASE1; Region: MASE1; cl17823
194439003327 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
194439003328 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
194439003329 HlyD family secretion protein; Region: HlyD_3; pfam13437
194439003330 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
194439003331 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
194439003332 DNA binding site [nucleotide binding]
194439003333 active site
194439003334 UbiA family of prenyltransferases (PTases); Region: PT_UbiA; cl00337
194439003335 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
194439003336 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
194439003337 active site
194439003338 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
194439003339 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
194439003340 magnesium chelatase, H subunit; Region: BchH; TIGR02025
194439003341 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965
194439003342 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
194439003343 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
194439003344 magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031
194439003345 Walker A motif; other site
194439003346 ATP binding site [chemical binding]; other site
194439003347 Walker B motif; other site
194439003348 arginine finger; other site
194439003349 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
194439003350 metal ion-dependent adhesion site (MIDAS); other site
194439003351 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
194439003352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
194439003353 Walker A motif; other site
194439003354 ATP binding site [chemical binding]; other site
194439003355 Walker B motif; other site
194439003356 arginine finger; other site
194439003357 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
194439003358 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
194439003359 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
194439003360 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
194439003361 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
194439003362 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
194439003363 RNA binding surface [nucleotide binding]; other site
194439003364 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
194439003365 active site
194439003366 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
194439003367 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
194439003368 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
194439003369 A new structural DNA glycosylase; Region: AlkD_like; cd06561
194439003370 active site
194439003371 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
194439003372 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
194439003373 ABC transporter; Region: ABC_tran_2; pfam12848
194439003374 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
194439003375 Spectrin repeats; Region: SPEC; smart00150
194439003376 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
194439003377 YXWGXW repeat (2 copies); Region: YXWGXW; pfam12779
194439003378 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
194439003379 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
194439003380 classical (c) SDRs; Region: SDR_c; cd05233
194439003381 NAD(P) binding site [chemical binding]; other site
194439003382 active site
194439003383 Heavy-metal resistance; Region: Metal_resist; pfam13801
194439003384 dimer interface [polypeptide binding]; other site
194439003385 Putative lysophospholipase; Region: Hydrolase_4; cl19140
194439003386 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
194439003387 thymidylate kinase; Validated; Region: tmk; PRK00698
194439003388 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
194439003389 TMP-binding site; other site
194439003390 ATP-binding site [chemical binding]; other site
194439003391 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
194439003392 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
194439003393 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137
194439003394 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
194439003395 motif II; other site
194439003396 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
194439003397 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
194439003398 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
194439003399 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
194439003400 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
194439003401 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
194439003402 substrate binding site; other site
194439003403 dimer interface; other site
194439003404 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
194439003405 CoenzymeA binding site [chemical binding]; other site
194439003406 subunit interaction site [polypeptide binding]; other site
194439003407 PHB binding site; other site
194439003408 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
194439003409 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
194439003410 B12 binding site [chemical binding]; other site
194439003411 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
194439003412 FeS/SAM binding site; other site
194439003413 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
194439003414 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
194439003415 dimer interface [polypeptide binding]; other site
194439003416 anticodon binding site; other site
194439003417 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
194439003418 homodimer interface [polypeptide binding]; other site
194439003419 motif 1; other site
194439003420 active site
194439003421 motif 2; other site
194439003422 GAD domain; Region: GAD; pfam02938
194439003423 motif 3; other site
194439003424 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14954
194439003425 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
194439003426 Walker A motif; other site
194439003427 ATP binding site [chemical binding]; other site
194439003428 Walker B motif; other site
194439003429 arginine finger; other site
194439003430 YihY family inner membrane protein; Region: yihY_not_rbn; TIGR00765
194439003431 Rubrerythrin [Energy production and conversion]; Region: COG1592
194439003432 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
194439003433 binuclear metal center [ion binding]; other site
194439003434 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
194439003435 iron binding site [ion binding]; other site
194439003436 DPS-like protein, ferritin-like diiron-binding domain; Region: DPSL; cd01052
194439003437 Ferritin-like domain; Region: Ferritin; pfam00210
194439003438 diiron binding motif [ion binding]; other site
194439003439 bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604
194439003440 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
194439003441 trimer interface [polypeptide binding]; other site
194439003442 dimer interface [polypeptide binding]; other site
194439003443 putative active site [active]
194439003444 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
194439003445 MPT binding site; other site
194439003446 trimer interface [polypeptide binding]; other site
194439003447 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
194439003448 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
194439003449 dimer interface [polypeptide binding]; other site
194439003450 putative functional site; other site
194439003451 putative MPT binding site; other site
194439003452 putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MobA; Provisional; Region: PRK14490
194439003453 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
194439003454 Walker A motif; other site
194439003455 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
194439003456 GTP binding site; other site
194439003457 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
194439003458 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
194439003459 FeS/SAM binding site; other site
194439003460 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
194439003461 MOSC domain; Region: MOSC; pfam03473
194439003462 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
194439003463 Protein of unknown function (DUF1847); Region: DUF1847; pfam08901
194439003464 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
194439003465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
194439003466 putative substrate translocation pore; other site
194439003467 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
194439003468 putative active site [active]
194439003469 catalytic triad [active]
194439003470 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
194439003471 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
194439003472 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
194439003473 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
194439003474 oligomerization interface [polypeptide binding]; other site
194439003475 active site
194439003476 metal binding site [ion binding]; metal-binding site
194439003477 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
194439003478 Predicted CoA-binding protein [General function prediction only]; Region: COG1832
194439003479 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
194439003480 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
194439003481 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
194439003482 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
194439003483 Outer membrane efflux protein; Region: OEP; pfam02321
194439003484 Outer membrane efflux protein; Region: OEP; pfam02321
194439003485 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
194439003486 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
194439003487 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169
194439003488 HlyD family secretion protein; Region: HlyD_3; pfam13437
194439003489 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
194439003490 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
194439003491 Walker A/P-loop; other site
194439003492 ATP binding site [chemical binding]; other site
194439003493 Q-loop/lid; other site
194439003494 ABC transporter signature motif; other site
194439003495 Walker B; other site
194439003496 D-loop; other site
194439003497 H-loop/switch region; other site
194439003498 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
194439003499 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
194439003500 FtsX-like permease family; Region: FtsX; pfam02687
194439003501 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
194439003502 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
194439003503 FtsX-like permease family; Region: FtsX; pfam02687
194439003504 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
194439003505 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
194439003506 ligand binding site [chemical binding]; other site
194439003507 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
194439003508 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756
194439003509 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232
194439003510 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
194439003511 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
194439003512 dimer interface [polypeptide binding]; other site
194439003513 phosphorylation site [posttranslational modification]
194439003514 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
194439003515 ATP binding site [chemical binding]; other site
194439003516 Mg2+ binding site [ion binding]; other site
194439003517 G-X-G motif; other site
194439003518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
194439003519 active site
194439003520 phosphorylation site [posttranslational modification]
194439003521 intermolecular recognition site; other site
194439003522 dimerization interface [polypeptide binding]; other site
194439003523 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
194439003524 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
194439003525 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
194439003526 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
194439003527 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
194439003528 trimer interface [polypeptide binding]; other site
194439003529 active site
194439003530 UDP-GlcNAc binding site [chemical binding]; other site
194439003531 lipid binding site [chemical binding]; lipid-binding site
194439003532 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
194439003533 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
194439003534 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
194439003535 active site
194439003536 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
194439003537 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
194439003538 5S rRNA interface [nucleotide binding]; other site
194439003539 CTC domain interface [polypeptide binding]; other site
194439003540 L16 interface [polypeptide binding]; other site
194439003541 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693
194439003542 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
194439003543 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
194439003544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
194439003545 dimer interface [polypeptide binding]; other site
194439003546 conserved gate region; other site
194439003547 putative PBP binding loops; other site
194439003548 ABC-ATPase subunit interface; other site
194439003549 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
194439003550 dimer interface [polypeptide binding]; other site
194439003551 ADP-ribose binding site [chemical binding]; other site
194439003552 active site
194439003553 nudix motif; other site
194439003554 metal binding site [ion binding]; metal-binding site
194439003555 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
194439003556 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
194439003557 Competence protein; Region: Competence; pfam03772
194439003558 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
194439003559 FAD binding site [chemical binding]; other site
194439003560 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
194439003561 putative ligand binding pocket/active site [active]
194439003562 putative metal binding site [ion binding]; other site
194439003563 diaminopimelate decarboxylase; Region: lysA; TIGR01048
194439003564 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
194439003565 active site
194439003566 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
194439003567 substrate binding site [chemical binding]; other site
194439003568 catalytic residues [active]
194439003569 dimer interface [polypeptide binding]; other site
194439003570 Ribosomal protein L33; Region: Ribosomal_L33; cl00383
194439003571 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
194439003572 Formin Homology 2 Domain; Region: FH2; cl19758
194439003573 Putative zinc ribbon domain; Region: DUF164; pfam02591
194439003574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
194439003575 ATP binding site [chemical binding]; other site
194439003576 Mg2+ binding site [ion binding]; other site
194439003577 G-X-G motif; other site
194439003578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
194439003579 active site
194439003580 phosphorylation site [posttranslational modification]
194439003581 intermolecular recognition site; other site
194439003582 dimerization interface [polypeptide binding]; other site
194439003583 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
194439003584 PAS fold; Region: PAS_3; pfam08447
194439003585 putative active site [active]
194439003586 heme pocket [chemical binding]; other site
194439003587 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
194439003588 putative active site [active]
194439003589 heme pocket [chemical binding]; other site
194439003590 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
194439003591 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
194439003592 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
194439003593 pyridoxal 5'-phosphate binding site [chemical binding]; other site
194439003594 homodimer interface [polypeptide binding]; other site
194439003595 catalytic residue [active]
194439003596 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
194439003597 catalytic loop [active]
194439003598 iron binding site [ion binding]; other site
194439003599 probable rRNA maturation factor YbeY; Region: TIGR00043
194439003600 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
194439003601 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
194439003602 HflX GTPase family; Region: HflX; cd01878
194439003603 G1 box; other site
194439003604 GTP/Mg2+ binding site [chemical binding]; other site
194439003605 Switch I region; other site
194439003606 G2 box; other site
194439003607 G3 box; other site
194439003608 Switch II region; other site
194439003609 G4 box; other site
194439003610 G5 box; other site
194439003611 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
194439003612 active site lid residues [active]
194439003613 substrate binding pocket [chemical binding]; other site
194439003614 catalytic residues [active]
194439003615 substrate-Mg2+ binding site; other site
194439003616 aspartate-rich region 1; other site
194439003617 aspartate-rich region 2; other site
194439003618 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
194439003619 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
194439003620 dimer interface [polypeptide binding]; other site
194439003621 putative anticodon binding site; other site
194439003622 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
194439003623 motif 1; other site
194439003624 active site
194439003625 motif 2; other site
194439003626 motif 3; other site
194439003627 Superinfection immunity protein; Region: Imm_superinfect; pfam14373
194439003628 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862
194439003629 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
194439003630 Cl- selectivity filter; other site
194439003631 Cl- binding residues [ion binding]; other site
194439003632 pore gating glutamate residue; other site
194439003633 dimer interface [polypeptide binding]; other site
194439003634 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613
194439003635 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
194439003636 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
194439003637 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
194439003638 putative active site [active]
194439003639 heme pocket [chemical binding]; other site
194439003640 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
194439003641 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
194439003642 putative active site [active]
194439003643 heme pocket [chemical binding]; other site
194439003644 GAF domain; Region: GAF_2; pfam13185
194439003645 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
194439003646 dimer interface [polypeptide binding]; other site
194439003647 phosphorylation site [posttranslational modification]
194439003648 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
194439003649 ATP binding site [chemical binding]; other site
194439003650 Mg2+ binding site [ion binding]; other site
194439003651 G-X-G motif; other site
194439003652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
194439003653 active site
194439003654 phosphorylation site [posttranslational modification]
194439003655 intermolecular recognition site; other site
194439003656 dimerization interface [polypeptide binding]; other site
194439003657 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
194439003658 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
194439003659 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
194439003660 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
194439003661 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
194439003662 FeS/SAM binding site; other site
194439003663 HB1, ASXL, restriction endonuclease HTH domain; Region: HARE-HTH; pfam05066
194439003664 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2958
194439003665 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
194439003666 Zn2+ binding site [ion binding]; other site
194439003667 Mg2+ binding site [ion binding]; other site
194439003668 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
194439003669 Helix-hairpin-helix domain; Region: HHH_5; pfam14520
194439003670 Helix-hairpin-helix containing domain; Region: HHH_4; pfam14490
194439003671 AAA domain; Region: AAA_30; pfam13604
194439003672 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538
194439003673 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
194439003674 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
194439003675 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
194439003676 ADP binding site [chemical binding]; other site
194439003677 magnesium binding site [ion binding]; other site
194439003678 putative shikimate binding site; other site
194439003679 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
194439003680 active site
194439003681 dimer interface [polypeptide binding]; other site
194439003682 metal binding site [ion binding]; metal-binding site
194439003683 pantothenate kinase; Reviewed; Region: PRK13320
194439003684 Uncharacterized conserved protein [Function unknown]; Region: COG0432
194439003685 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
194439003686 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
194439003687 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
194439003688 Transcriptional regulators [Transcription]; Region: Lrp; COG1522
194439003689 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
194439003690 dimerization interface [polypeptide binding]; other site
194439003691 putative DNA binding site [nucleotide binding]; other site
194439003692 putative Zn2+ binding site [ion binding]; other site
194439003693 AsnC family; Region: AsnC_trans_reg; pfam01037
194439003694 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
194439003695 phytoene desaturase; Region: phytoene_desat; TIGR02731
194439003696 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
194439003697 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
194439003698 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
194439003699 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
194439003700 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
194439003701 Probable Catalytic site; other site
194439003702 chlorosome envelope protein H repeat; Region: rpt_csmH; TIGR03058
194439003703 chlorosome envelope protein H repeat; Region: rpt_csmH; TIGR03058
194439003704 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
194439003705 trimer interface [polypeptide binding]; other site
194439003706 active site
194439003707 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001
194439003708 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
194439003709 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514
194439003710 peptide binding site [polypeptide binding]; other site
194439003711 2-vinyl bacteriochlorophyllide hydratase; Region: BchF; TIGR02020
194439003712 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202
194439003713 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
194439003714 putative NAD(P) binding site [chemical binding]; other site
194439003715 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
194439003716 chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016
194439003717 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
194439003718 DNA binding residues [nucleotide binding]
194439003719 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
194439003720 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
194439003721 G1 box; other site
194439003722 putative GEF interaction site [polypeptide binding]; other site
194439003723 GTP/Mg2+ binding site [chemical binding]; other site
194439003724 Switch I region; other site
194439003725 G2 box; other site
194439003726 G3 box; other site
194439003727 Switch II region; other site
194439003728 G4 box; other site
194439003729 G5 box; other site
194439003730 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
194439003731 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710
194439003732 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
194439003733 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
194439003734 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
194439003735 tRNA; other site
194439003736 putative tRNA binding site [nucleotide binding]; other site
194439003737 putative NADP binding site [chemical binding]; other site
194439003738 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745
194439003739 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
194439003740 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
194439003741 domain interfaces; other site
194439003742 active site
194439003743 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
194439003744 active site
194439003745 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
194439003746 active site
194439003747 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
194439003748 dimer interface [polypeptide binding]; other site
194439003749 active site
194439003750 aspartate-rich active site metal binding site; other site
194439003751 allosteric magnesium binding site [ion binding]; other site
194439003752 Schiff base residues; other site
194439003753 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
194439003754 Tetramer interface [polypeptide binding]; other site
194439003755 active site
194439003756 FMN-binding site [chemical binding]; other site
194439003757 serine acetyltransferase; Provisional; Region: cysE; PRK11132
194439003758 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971
194439003759 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
194439003760 trimer interface [polypeptide binding]; other site
194439003761 active site
194439003762 substrate binding site [chemical binding]; other site
194439003763 CoA binding site [chemical binding]; other site
194439003764 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
194439003765 active site
194439003766 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731
194439003767 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
194439003768 FeS/SAM binding site; other site
194439003769 PUCC protein; Region: PUCC; pfam03209
194439003770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
194439003771 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
194439003772 ThiC-associated domain; Region: ThiC-associated; pfam13667
194439003773 ThiC family; Region: ThiC; pfam01964
194439003774 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358
194439003775 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
194439003776 substrate binding site [chemical binding]; other site
194439003777 dimer interface [polypeptide binding]; other site
194439003778 catalytic triad [active]
194439003779 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
194439003780 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
194439003781 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
194439003782 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
194439003783 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
194439003784 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
194439003785 protein binding site [polypeptide binding]; other site
194439003786 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
194439003787 protein binding site [polypeptide binding]; other site
194439003788 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
194439003789 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
194439003790 chorismate binding enzyme; Region: Chorismate_bind; pfam00425
194439003791 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
194439003792 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
194439003793 Catalytic site [active]
194439003794 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
194439003795 GTP-binding protein LepA; Provisional; Region: PRK05433
194439003796 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
194439003797 G1 box; other site
194439003798 putative GEF interaction site [polypeptide binding]; other site
194439003799 GTP/Mg2+ binding site [chemical binding]; other site
194439003800 Switch I region; other site
194439003801 G2 box; other site
194439003802 G3 box; other site
194439003803 Switch II region; other site
194439003804 G4 box; other site
194439003805 G5 box; other site
194439003806 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
194439003807 Elongation Factor G, domain II; Region: EFG_II; pfam14492
194439003808 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
194439003809 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
194439003810 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
194439003811 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
194439003812 putative active site [active]
194439003813 substrate binding site [chemical binding]; other site
194439003814 putative cosubstrate binding site; other site
194439003815 catalytic site [active]
194439003816 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
194439003817 substrate binding site [chemical binding]; other site
194439003818 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
194439003819 active site
194439003820 catalytic residues [active]
194439003821 metal binding site [ion binding]; metal-binding site
194439003822 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
194439003823 metal binding site 2 [ion binding]; metal-binding site
194439003824 putative DNA binding helix; other site
194439003825 metal binding site 1 [ion binding]; metal-binding site
194439003826 dimer interface [polypeptide binding]; other site
194439003827 structural Zn2+ binding site [ion binding]; other site
194439003828 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
194439003829 gamma-glutamyl kinase; Provisional; Region: PRK05429
194439003830 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
194439003831 nucleotide binding site [chemical binding]; other site
194439003832 homotetrameric interface [polypeptide binding]; other site
194439003833 putative phosphate binding site [ion binding]; other site
194439003834 putative allosteric binding site; other site
194439003835 PUA domain; Region: PUA; pfam01472
194439003836 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
194439003837 binding surface
194439003838 TPR repeat; Region: TPR_11; pfam13414
194439003839 TPR motif; other site
194439003840 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
194439003841 Domain of unknown function (DUF4403); Region: DUF4403; pfam14356
194439003842 TIR domain; Region: TIR_2; pfam13676
194439003843 rod shape-determining protein MreB; Provisional; Region: PRK13930
194439003844 MreB and similar proteins; Region: MreB_like; cd10225
194439003845 nucleotide binding site [chemical binding]; other site
194439003846 Mg binding site [ion binding]; other site
194439003847 putative protofilament interaction site [polypeptide binding]; other site
194439003848 RodZ interaction site [polypeptide binding]; other site
194439003849 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
194439003850 amphipathic channel; other site
194439003851 Asn-Pro-Ala signature motifs; other site
194439003852 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
194439003853 putative catalytic cysteine [active]
194439003854 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
194439003855 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
194439003856 Walker A/P-loop; other site
194439003857 ATP binding site [chemical binding]; other site
194439003858 Q-loop/lid; other site
194439003859 ABC transporter signature motif; other site
194439003860 Walker B; other site
194439003861 D-loop; other site
194439003862 H-loop/switch region; other site
194439003863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
194439003864 Major Facilitator Superfamily; Region: MFS_1; pfam07690
194439003865 putative substrate translocation pore; other site
194439003866 putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574
194439003867 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
194439003868 inhibitor-cofactor binding pocket; inhibition site
194439003869 pyridoxal 5'-phosphate binding site [chemical binding]; other site
194439003870 catalytic residue [active]
194439003871 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773
194439003872 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
194439003873 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
194439003874 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
194439003875 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
194439003876 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
194439003877 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
194439003878 Flavodoxin domain; Region: Flavodoxin_5; cl17428
194439003879 Flavodoxin domain; Region: Flavodoxin_5; cl17428
194439003880 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
194439003881 chaperone protein DnaJ; Provisional; Region: PRK14281
194439003882 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
194439003883 HSP70 interaction site [polypeptide binding]; other site
194439003884 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
194439003885 substrate binding site [polypeptide binding]; other site
194439003886 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
194439003887 Zn binding sites [ion binding]; other site
194439003888 dimer interface [polypeptide binding]; other site
194439003889 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
194439003890 dimer interface [polypeptide binding]; other site
194439003891 hsp70 (ATPase domain) interactions [polypeptide binding]; other site
194439003892 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
194439003893 heat shock gene repressor HrcA; Region: hrcA; TIGR00331
194439003894 HrcA protein C terminal domain; Region: HrcA; pfam01628
194439003895 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
194439003896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
194439003897 S-adenosylmethionine binding site [chemical binding]; other site
194439003898 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
194439003899 prolyl-tRNA synthetase; Provisional; Region: PRK08661
194439003900 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
194439003901 dimer interface [polypeptide binding]; other site
194439003902 motif 1; other site
194439003903 active site
194439003904 motif 2; other site
194439003905 motif 3; other site
194439003906 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
194439003907 anticodon binding site; other site
194439003908 zinc-binding site [ion binding]; other site
194439003909 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
194439003910 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
194439003911 dimer interface [polypeptide binding]; other site
194439003912 decamer (pentamer of dimers) interface [polypeptide binding]; other site
194439003913 catalytic triad [active]
194439003914 peroxidatic and resolving cysteines [active]
194439003915 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252
194439003916 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_8; cd07586
194439003917 putative active site [active]
194439003918 catalytic triad [active]
194439003919 putative dimer interface [polypeptide binding]; other site
194439003920 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14616
194439003921 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
194439003922 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
194439003923 Sporulation related domain; Region: SPOR; pfam05036
194439003924 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
194439003925 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
194439003926 Walker A motif; other site
194439003927 ATP binding site [chemical binding]; other site
194439003928 Walker B motif; other site
194439003929 arginine finger; other site
194439003930 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
194439003931 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
194439003932 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
194439003933 putative active site [active]
194439003934 catalytic triad [active]
194439003935 putative dimer interface [polypeptide binding]; other site
194439003936 Bacteriochlorophyll A protein; Region: BChl_A; pfam02327
194439003937 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
194439003938 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
194439003939 DNA binding residues [nucleotide binding]
194439003940 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
194439003941 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
194439003942 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
194439003943 Walker A/P-loop; other site
194439003944 ATP binding site [chemical binding]; other site
194439003945 Q-loop/lid; other site
194439003946 ABC transporter signature motif; other site
194439003947 Walker B; other site
194439003948 D-loop; other site
194439003949 H-loop/switch region; other site
194439003950 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
194439003951 B12 binding site [chemical binding]; other site
194439003952 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
194439003953 Radical SAM superfamily; Region: Radical_SAM; pfam04055
194439003954 FeS/SAM binding site; other site
194439003955 DNA mismatch repair protein MutS; Provisional; Region: PRK05399
194439003956 MutS domain I; Region: MutS_I; pfam01624
194439003957 MutS domain II; Region: MutS_II; pfam05188
194439003958 MutS domain III; Region: MutS_III; pfam05192
194439003959 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
194439003960 Walker A/P-loop; other site
194439003961 ATP binding site [chemical binding]; other site
194439003962 Q-loop/lid; other site
194439003963 ABC transporter signature motif; other site
194439003964 Walker B; other site
194439003965 D-loop; other site
194439003966 H-loop/switch region; other site
194439003967 Copper resistance protein D; Region: CopD; pfam05425
194439003968 50S ribosomal protein L21; Validated; Region: rplU; PRK05573
194439003969 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
194439003970 malate dehydrogenase, NAD-dependent; Region: MalateDH_bact; TIGR01763
194439003971 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
194439003972 NAD(P) binding site [chemical binding]; other site
194439003973 dimer interface [polypeptide binding]; other site
194439003974 tetramer (dimer of dimers) interface [polypeptide binding]; other site
194439003975 substrate binding site [chemical binding]; other site
194439003976 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
194439003977 Peptidase family M48; Region: Peptidase_M48; pfam01435
194439003978 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
194439003979 putative active site; other site
194439003980 catalytic triad [active]
194439003981 putative dimer interface [polypeptide binding]; other site
194439003982 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962
194439003983 putative active site [active]
194439003984 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
194439003985 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
194439003986 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
194439003987 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
194439003988 substrate binding site [chemical binding]; other site
194439003989 glutamase interaction surface [polypeptide binding]; other site
194439003990 VanZ like family; Region: VanZ; cl01971
194439003991 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
194439003992 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
194439003993 putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574
194439003994 Putative addiction module component; Region: Unstab_antitox; pfam09720
194439003995 putative phosphoketolase; Provisional; Region: PRK05261
194439003996 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
194439003997 TPP-binding site; other site
194439003998 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894
194439003999 XFP C-terminal domain; Region: XFP_C; pfam09363
194439004000 Acetokinase family; Region: Acetate_kinase; cl17229
194439004001 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
194439004002 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116
194439004003 Leucine rich repeat; Region: LRR_8; pfam13855
194439004004 Leucine-rich repeats; other site
194439004005 Substrate binding site [chemical binding]; other site
194439004006 Leucine rich repeat; Region: LRR_8; pfam13855
194439004007 Leucine rich repeat; Region: LRR_8; pfam13855
194439004008 Leucine rich repeat; Region: LRR_8; pfam13855
194439004009 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
194439004010 Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family; Region: RocCOR; cd09914
194439004011 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
194439004012 G1 box; other site
194439004013 GTP/Mg2+ binding site [chemical binding]; other site
194439004014 G2 box; other site
194439004015 Switch I region; other site
194439004016 G3 box; other site
194439004017 Switch II region; other site
194439004018 G4 box; other site
194439004019 G5 box; other site
194439004020 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
194439004021 active site
194439004022 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660
194439004023 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
194439004024 active site
194439004025 catalytic residues [active]
194439004026 metal binding site [ion binding]; metal-binding site
194439004027 Nif-specific regulatory protein; Region: nifA; TIGR01817
194439004028 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
194439004029 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
194439004030 Walker A motif; other site
194439004031 ATP binding site [chemical binding]; other site
194439004032 Walker B motif; other site
194439004033 arginine finger; other site
194439004034 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
194439004035 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
194439004036 nitrogenase iron protein; Region: nifH; TIGR01287
194439004037 Nucleotide-binding sites [chemical binding]; other site
194439004038 Walker A motif; other site
194439004039 Switch I region of nucleotide binding site; other site
194439004040 Fe4S4 binding sites [ion binding]; other site
194439004041 Switch II region of nucleotide binding site; other site
194439004042 Nitrogen regulatory protein P-II; Region: P-II; pfam00543
194439004043 Nitrogen regulatory protein P-II; Region: P-II; pfam00543
194439004044 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
194439004045 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710
194439004046 MoFe protein alpha/beta subunit interactions; other site
194439004047 Alpha subunit P cluster binding residues; other site
194439004048 FeMoco binding residues [chemical binding]; other site
194439004049 MoFe protein alpha subunit/Fe protein contacts; other site
194439004050 MoFe protein dimer/ dimer interactions; other site
194439004051 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710
194439004052 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
194439004053 MoFe protein beta/alpha subunit interactions; other site
194439004054 Beta subunit P cluster binding residues; other site
194439004055 MoFe protein beta subunit/Fe protein contacts; other site
194439004056 MoFe protein dimer/ dimer interactions; other site
194439004057 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710
194439004058 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968
194439004059 Nitrogenase_nifN_2: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_2; cd03466
194439004060 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
194439004061 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
194439004062 FeS/SAM binding site; other site
194439004063 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
194439004064 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
194439004065 dimer interface [polypeptide binding]; other site
194439004066 [2Fe-2S] cluster binding site [ion binding]; other site
194439004067 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
194439004068 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
194439004069 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
194439004070 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
194439004071 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
194439004072 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
194439004073 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
194439004074 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
194439004075 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
194439004076 Zn2+ binding site [ion binding]; other site
194439004077 Mg2+ binding site [ion binding]; other site
194439004078 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
194439004079 synthetase active site [active]
194439004080 NTP binding site [chemical binding]; other site
194439004081 metal binding site [ion binding]; metal-binding site
194439004082 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
194439004083 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
194439004084 excinuclease ABC subunit B; Provisional; Region: PRK05298
194439004085 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
194439004086 ATP binding site [chemical binding]; other site
194439004087 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
194439004088 putative Mg++ binding site [ion binding]; other site
194439004089 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
194439004090 nucleotide binding region [chemical binding]; other site
194439004091 ATP-binding site [chemical binding]; other site
194439004092 Ultra-violet resistance protein B; Region: UvrB; pfam12344
194439004093 UvrB/uvrC motif; Region: UVR; pfam02151
194439004094 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
194439004095 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
194439004096 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
194439004097 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
194439004098 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
194439004099 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
194439004100 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
194439004101 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
194439004102 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
194439004103 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
194439004104 active site
194439004105 HIGH motif; other site
194439004106 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
194439004107 KMSKS motif; other site
194439004108 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
194439004109 tRNA binding surface [nucleotide binding]; other site
194439004110 anticodon binding site; other site
194439004111 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
194439004112 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
194439004113 oligomer interface [polypeptide binding]; other site
194439004114 active site residues [active]
194439004115 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
194439004116 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172
194439004117 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
194439004118 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
194439004119 active site
194439004120 nucleophile elbow; other site
194439004121 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
194439004122 Surface antigen; Region: Bac_surface_Ag; pfam01103
194439004123 stationary phase survival protein SurE; Provisional; Region: PRK13932
194439004124 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079
194439004125 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
194439004126 ResB-like family; Region: ResB; cl09125
194439004127 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
194439004128 non-specific DNA binding site [nucleotide binding]; other site
194439004129 salt bridge; other site
194439004130 sequence-specific DNA binding site [nucleotide binding]; other site
194439004131 Haem-binding domain; Region: Haem_bd; pfam14376
194439004132 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
194439004133 para-aminobenzoate synthase component II; Provisional; Region: PRK08857
194439004134 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
194439004135 glutamine binding [chemical binding]; other site
194439004136 catalytic triad [active]
194439004137 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991
194439004138 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562
194439004139 Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635
194439004140 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
194439004141 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
194439004142 Low molecular weight phosphatase family; Region: LMWPc; cd00115
194439004143 active site
194439004144 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
194439004145 response regulator; Provisional; Region: PRK09483
194439004146 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
194439004147 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902
194439004148 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
194439004149 NAD(P) binding site [chemical binding]; other site
194439004150 catalytic residues [active]
194439004151 GTPase RsgA; Reviewed; Region: PRK00098
194439004152 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
194439004153 RNA binding site [nucleotide binding]; other site
194439004154 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
194439004155 GTPase/Zn-binding domain interface [polypeptide binding]; other site
194439004156 GTP/Mg2+ binding site [chemical binding]; other site
194439004157 G4 box; other site
194439004158 G5 box; other site
194439004159 G1 box; other site
194439004160 Switch I region; other site
194439004161 G2 box; other site
194439004162 G3 box; other site
194439004163 Switch II region; other site
194439004164 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
194439004165 Helix-hairpin-helix domain; Region: HHH_5; pfam14520
194439004166 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
194439004167 generic binding surface II; other site
194439004168 ssDNA binding site; other site
194439004169 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
194439004170 ATP binding site [chemical binding]; other site
194439004171 putative Mg++ binding site [ion binding]; other site
194439004172 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
194439004173 nucleotide binding region [chemical binding]; other site
194439004174 ATP-binding site [chemical binding]; other site
194439004175 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
194439004176 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
194439004177 hinge region; other site
194439004178 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
194439004179 DNA binding site [nucleotide binding]
194439004180 active site
194439004181 Int/Topo IB signature motif; other site
194439004182 Membrane protein of unknown function; Region: DUF360; cl00850
194439004183 HemX; Region: HemX; cl19375
194439004184 Short C-terminal domain; Region: SHOCT; pfam09851
194439004185 Protein of unknown function (DUF805); Region: DUF805; pfam05656
194439004186 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
194439004187 Gram-negative bacterial TonB protein C-terminal; Region: TonB_C; pfam03544
194439004188 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
194439004189 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
194439004190 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
194439004191 DNA primase; Validated; Region: dnaG; PRK05667
194439004192 CHC2 zinc finger; Region: zf-CHC2; cl17510
194439004193 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
194439004194 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
194439004195 active site
194439004196 metal binding site [ion binding]; metal-binding site
194439004197 interdomain interaction site; other site
194439004198 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
194439004199 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
194439004200 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
194439004201 dimer interface [polypeptide binding]; other site
194439004202 active site
194439004203 glycine-pyridoxal phosphate binding site [chemical binding]; other site
194439004204 folate binding site [chemical binding]; other site
194439004205 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
194439004206 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
194439004207 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
194439004208 dimerization interface [polypeptide binding]; other site
194439004209 active site
194439004210 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096
194439004211 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
194439004212 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
194439004213 ATP-grasp domain; Region: ATP-grasp_4; cl17255
194439004214 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
194439004215 IMP binding site; other site
194439004216 dimer interface [polypeptide binding]; other site
194439004217 interdomain contacts; other site
194439004218 partial ornithine binding site; other site
194439004219 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
194439004220 dinuclear metal binding motif [ion binding]; other site
194439004221 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
194439004222 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
194439004223 putative active site [active]
194439004224 putative metal binding site [ion binding]; other site
194439004225 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
194439004226 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
194439004227 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
194439004228 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
194439004229 heterodimer interface [polypeptide binding]; other site
194439004230 active site
194439004231 FMN binding site [chemical binding]; other site
194439004232 homodimer interface [polypeptide binding]; other site
194439004233 substrate binding site [chemical binding]; other site
194439004234 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
194439004235 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113
194439004236 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
194439004237 homotrimer interaction site [polypeptide binding]; other site
194439004238 zinc binding site [ion binding]; other site
194439004239 CDP-binding sites; other site
194439004240 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
194439004241 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
194439004242 FtsX-like permease family; Region: FtsX; pfam02687
194439004243 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
194439004244 active site
194439004245 ADP/pyrophosphate binding site [chemical binding]; other site
194439004246 allosteric effector site; other site
194439004247 dimerization interface [polypeptide binding]; other site
194439004248 fructose-1,6-bisphosphate binding site; other site
194439004249 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
194439004250 homodimer interface [polypeptide binding]; other site
194439004251 substrate-cofactor binding pocket; other site
194439004252 catalytic residue [active]
194439004253 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
194439004254 DNA polymerase III subunit delta'; Validated; Region: PRK08485
194439004255 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470
194439004256 CutA1 divalent ion tolerance protein; Region: CutA1; pfam03091
194439004257 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
194439004258 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
194439004259 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
194439004260 active site
194439004261 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
194439004262 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
194439004263 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
194439004264 Bacteriochlorophyll/chlorophyll synthetase; Region: PT_UbiA_chlorophyll; cd13958
194439004265 putative active site [active]
194439004266 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
194439004267 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
194439004268 RNA/DNA hybrid binding site [nucleotide binding]; other site
194439004269 active site
194439004270 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
194439004271 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
194439004272 Ligand Binding Site [chemical binding]; other site
194439004273 phosphatidylserine decarboxylase; Provisional; Region: PRK05305
194439004274 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
194439004275 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
194439004276 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
194439004277 Walker A/P-loop; other site
194439004278 ATP binding site [chemical binding]; other site
194439004279 Q-loop/lid; other site
194439004280 Laminin Domain II; Region: Laminin_II; pfam06009
194439004281 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
194439004282 ABC transporter signature motif; other site
194439004283 Walker B; other site
194439004284 D-loop; other site
194439004285 H-loop/switch region; other site
194439004286 AAA domain; Region: AAA_11; pfam13086
194439004287 Part of AAA domain; Region: AAA_19; pfam13245
194439004288 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
194439004289 AAA domain; Region: AAA_12; pfam13087
194439004290 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
194439004291 additional DNA contacts [nucleotide binding]; other site
194439004292 mismatch recognition site; other site
194439004293 active site
194439004294 zinc binding site [ion binding]; other site
194439004295 DNA intercalation site [nucleotide binding]; other site
194439004296 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
194439004297 dimer interface [polypeptide binding]; other site
194439004298 active site
194439004299 catalytic residue [active]
194439004300 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
194439004301 tetramer interface [polypeptide binding]; other site
194439004302 pyridoxal 5'-phosphate binding site [chemical binding]; other site
194439004303 catalytic residue [active]
194439004304 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
194439004305 lipoyl attachment site [posttranslational modification]; other site
194439004306 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
194439004307 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
194439004308 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
194439004309 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
194439004310 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
194439004311 dimer interface [polypeptide binding]; other site
194439004312 PYR/PP interface [polypeptide binding]; other site
194439004313 TPP binding site [chemical binding]; other site
194439004314 substrate binding site [chemical binding]; other site
194439004315 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
194439004316 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
194439004317 Domain of unknown function; Region: EKR; pfam10371
194439004318 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
194439004319 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
194439004320 TPP-binding site [chemical binding]; other site
194439004321 dimer interface [polypeptide binding]; other site
194439004322 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
194439004323 binding surface
194439004324 TPR motif; other site
194439004325 TPR repeat; Region: TPR_11; pfam13414
194439004326 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
194439004327 binding surface
194439004328 TPR motif; other site
194439004329 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
194439004330 binding surface
194439004331 TPR motif; other site
194439004332 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
194439004333 binding surface
194439004334 TPR repeat; Region: TPR_11; pfam13414
194439004335 TPR motif; other site
194439004336 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
194439004337 binding surface
194439004338 TPR motif; other site
194439004339 TPR repeat; Region: TPR_11; pfam13414
194439004340 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
194439004341 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
194439004342 Walker A motif; other site
194439004343 ATP binding site [chemical binding]; other site
194439004344 Walker B motif; other site
194439004345 arginine finger; other site
194439004346 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
194439004347 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
194439004348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
194439004349 dimer interface [polypeptide binding]; other site
194439004350 conserved gate region; other site
194439004351 putative PBP binding loops; other site
194439004352 ABC-ATPase subunit interface; other site
194439004353 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514
194439004354 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
194439004355 peptide binding site [polypeptide binding]; other site
194439004356 HPr kinase/phosphorylase; Provisional; Region: PRK05428
194439004357 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
194439004358 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
194439004359 Hpr binding site; other site
194439004360 active site
194439004361 homohexamer subunit interaction site [polypeptide binding]; other site
194439004362 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
194439004363 30S subunit binding site; other site
194439004364 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
194439004365 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
194439004366 active site
194439004367 Int/Topo IB signature motif; other site
194439004368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
194439004369 S-adenosylmethionine binding site [chemical binding]; other site
194439004370 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
194439004371 Photosystem P840 reaction-centre cytochrome c-551; Region: Cytochrome-c551; pfam10643
194439004372 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
194439004373 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
194439004374 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
194439004375 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
194439004376 Walker A motif; other site
194439004377 ATP binding site [chemical binding]; other site
194439004378 Walker B motif; other site
194439004379 arginine finger; other site
194439004380 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
194439004381 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
194439004382 tandem repeat interface [polypeptide binding]; other site
194439004383 oligomer interface [polypeptide binding]; other site
194439004384 active site residues [active]
194439004385 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
194439004386 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
194439004387 tandem repeat interface [polypeptide binding]; other site
194439004388 oligomer interface [polypeptide binding]; other site
194439004389 active site residues [active]
194439004390 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
194439004391 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
194439004392 Walker A/P-loop; other site
194439004393 ATP binding site [chemical binding]; other site
194439004394 Q-loop/lid; other site
194439004395 ABC transporter signature motif; other site
194439004396 Walker B; other site
194439004397 D-loop; other site
194439004398 H-loop/switch region; other site
194439004399 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
194439004400 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
194439004401 putative SAM binding site [chemical binding]; other site
194439004402 putative homodimer interface [polypeptide binding]; other site
194439004403 Pantoate-beta-alanine ligase; Region: PanC; cd00560
194439004404 active site
194439004405 ATP-binding site [chemical binding]; other site
194439004406 pantoate-binding site; other site
194439004407 HXXH motif; other site
194439004408 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
194439004409 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
194439004410 RNase E interface [polypeptide binding]; other site
194439004411 trimer interface [polypeptide binding]; other site
194439004412 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
194439004413 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
194439004414 RNase E interface [polypeptide binding]; other site
194439004415 trimer interface [polypeptide binding]; other site
194439004416 active site
194439004417 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
194439004418 putative nucleic acid binding region [nucleotide binding]; other site
194439004419 G-X-X-G motif; other site
194439004420 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
194439004421 RNA binding site [nucleotide binding]; other site
194439004422 domain interface; other site
194439004423 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
194439004424 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
194439004425 active site
194439004426 HIGH motif; other site
194439004427 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
194439004428 KMSKS motif; other site
194439004429 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
194439004430 tRNA binding surface [nucleotide binding]; other site
194439004431 acetyl-CoA synthetase; Provisional; Region: PRK00174
194439004432 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
194439004433 active site
194439004434 CoA binding site [chemical binding]; other site
194439004435 acyl-activating enzyme (AAE) consensus motif; other site
194439004436 AMP binding site [chemical binding]; other site
194439004437 acetate binding site [chemical binding]; other site
194439004438 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
194439004439 dimerization interface [polypeptide binding]; other site
194439004440 putative DNA binding site [nucleotide binding]; other site
194439004441 putative Zn2+ binding site [ion binding]; other site
194439004442 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
194439004443 dimer interface [polypeptide binding]; other site
194439004444 [2Fe-2S] cluster binding site [ion binding]; other site
194439004445 Guanylate-binding protein, N-terminal domain; Region: GBP; cl19296
194439004446 TspO/MBR family; Region: TspO_MBR; pfam03073
194439004447 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
194439004448 active site
194439004449 dimerization interface [polypeptide binding]; other site
194439004450 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188
194439004451 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
194439004452 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
194439004453 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
194439004454 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
194439004455 active site
194439004456 putative DNA-binding cleft [nucleotide binding]; other site
194439004457 dimer interface [polypeptide binding]; other site
194439004458 hypothetical protein; Validated; Region: PRK00110
194439004459 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
194439004460 Prephenate dehydratase; Region: PDT; pfam00800
194439004461 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
194439004462 putative L-Phe binding site [chemical binding]; other site
194439004463 DNA polymerase I; Provisional; Region: PRK05755
194439004464 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
194439004465 active site
194439004466 metal binding site 1 [ion binding]; metal-binding site
194439004467 putative 5' ssDNA interaction site; other site
194439004468 metal binding site 3; metal-binding site
194439004469 metal binding site 2 [ion binding]; metal-binding site
194439004470 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
194439004471 putative DNA binding site [nucleotide binding]; other site
194439004472 putative metal binding site [ion binding]; other site
194439004473 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
194439004474 active site
194439004475 catalytic site [active]
194439004476 substrate binding site [chemical binding]; other site
194439004477 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
194439004478 active site
194439004479 DNA binding site [nucleotide binding]
194439004480 catalytic site [active]
194439004481 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
194439004482 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
194439004483 Surface antigen; Region: Bac_surface_Ag; pfam01103
194439004484 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
194439004485 substrate binding site [chemical binding]; other site
194439004486 hexamer interface [polypeptide binding]; other site
194439004487 metal binding site [ion binding]; metal-binding site
194439004488 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
194439004489 active site
194439004490 ribulose/triose binding site [chemical binding]; other site
194439004491 phosphate binding site [ion binding]; other site
194439004492 substrate (anthranilate) binding pocket [chemical binding]; other site
194439004493 product (indole) binding pocket [chemical binding]; other site
194439004494 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
194439004495 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
194439004496 ATP-grasp domain; Region: ATP-grasp_4; cl17255
194439004497 Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787
194439004498 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
194439004499 MPN+ (JAMM) motif; other site
194439004500 Zinc-binding site [ion binding]; other site
194439004501 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
194439004502 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
194439004503 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
194439004504 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
194439004505 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
194439004506 putative acyl-acceptor binding pocket; other site
194439004507 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
194439004508 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
194439004509 catalytic triad [active]
194439004510 dimer interface [polypeptide binding]; other site
194439004511 conserved cis-peptide bond; other site
194439004512 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
194439004513 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; pfam09603
194439004514 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
194439004515 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
194439004516 conserved cys residue [active]
194439004517 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
194439004518 TM-ABC transporter signature motif; other site
194439004519 pyruvate phosphate dikinase; Provisional; Region: PRK09279
194439004520 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
194439004521 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391
194439004522 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
194439004523 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
194439004524 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647
194439004525 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
194439004526 Soluble P-type ATPase [General function prediction only]; Region: COG4087
194439004527 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
194439004528 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
194439004529 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
194439004530 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
194439004531 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
194439004532 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
194439004533 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
194439004534 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782
194439004535 active site
194439004536 catalytic site [active]
194439004537 substrate binding site [chemical binding]; other site
194439004538 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108
194439004539 PAS domain S-box; Region: sensory_box; TIGR00229
194439004540 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
194439004541 putative active site [active]
194439004542 heme pocket [chemical binding]; other site
194439004543 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
194439004544 dimer interface [polypeptide binding]; other site
194439004545 phosphorylation site [posttranslational modification]
194439004546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
194439004547 ATP binding site [chemical binding]; other site
194439004548 Mg2+ binding site [ion binding]; other site
194439004549 G-X-G motif; other site
194439004550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
194439004551 active site
194439004552 phosphorylation site [posttranslational modification]
194439004553 intermolecular recognition site; other site
194439004554 dimerization interface [polypeptide binding]; other site
194439004555 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
194439004556 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
194439004557 motif II; other site
194439004558 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
194439004559 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
194439004560 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
194439004561 FeS/SAM binding site; other site
194439004562 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
194439004563 cubane metal cluster [ion binding]; other site
194439004564 hybrid metal cluster; other site
194439004565 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
194439004566 TPR repeat; Region: TPR_11; pfam13414
194439004567 binding surface
194439004568 TPR motif; other site
194439004569 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
194439004570 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
194439004571 Predicted transcriptional regulator [Transcription]; Region: COG1959
194439004572 Rrf2 family protein; Region: rrf2_super; TIGR00738
194439004573 Haem-binding domain; Region: Haem_bd; pfam14376
194439004574 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
194439004575 Peptidase family M50; Region: Peptidase_M50; pfam02163
194439004576 active site
194439004577 putative substrate binding region [chemical binding]; other site
194439004578 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294
194439004579 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
194439004580 substrate binding pocket [chemical binding]; other site
194439004581 dimer interface [polypeptide binding]; other site
194439004582 inhibitor binding site; inhibition site
194439004583 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
194439004584 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
194439004585 Walker A/P-loop; other site
194439004586 ATP binding site [chemical binding]; other site
194439004587 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
194439004588 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
194439004589 ABC transporter signature motif; other site
194439004590 Walker B; other site
194439004591 D-loop; other site
194439004592 H-loop/switch region; other site
194439004593 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
194439004594 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
194439004595 motif II; other site
194439004596 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
194439004597 putative RNA binding site [nucleotide binding]; other site
194439004598 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
194439004599 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
194439004600 minor groove reading motif; other site
194439004601 helix-hairpin-helix signature motif; other site
194439004602 substrate binding pocket [chemical binding]; other site
194439004603 active site
194439004604 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
194439004605 aminodeoxychorismate synthase; Provisional; Region: PRK07508
194439004606 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553
194439004607 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
194439004608 homodimer interface [polypeptide binding]; other site
194439004609 substrate-cofactor binding pocket; other site
194439004610 pyridoxal 5'-phosphate binding site [chemical binding]; other site
194439004611 catalytic residue [active]
194439004612 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
194439004613 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483
194439004614 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
194439004615 Zn2+ binding site [ion binding]; other site
194439004616 Mg2+ binding site [ion binding]; other site
194439004617 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
194439004618 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
194439004619 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
194439004620 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663
194439004621 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
194439004622 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
194439004623 ligand binding site [chemical binding]; other site
194439004624 flexible hinge region; other site
194439004625 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
194439004626 non-specific DNA interactions [nucleotide binding]; other site
194439004627 DNA binding site [nucleotide binding]
194439004628 sequence specific DNA binding site [nucleotide binding]; other site
194439004629 putative cAMP binding site [chemical binding]; other site
194439004630 Dicarboxylate transport; Region: DctA-YdbH; cl14674
194439004631 Dicarboxylate transport; Region: DctA-YdbH; pfam11739
194439004632 Protein of unknown function (DUF1318); Region: DUF1318; pfam07027
194439004633 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
194439004634 arsenical-resistance protein; Region: acr3; TIGR00832
194439004635 Low molecular weight phosphatase family; Region: LMWPc; cd00115
194439004636 active site
194439004637 Predicted permeases [General function prediction only]; Region: COG0701
194439004638 Thioredoxin domain; Region: Thioredoxin_3; pfam13192
194439004639 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
194439004640 dimerization interface [polypeptide binding]; other site
194439004641 putative DNA binding site [nucleotide binding]; other site
194439004642 putative Zn2+ binding site [ion binding]; other site
194439004643 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
194439004644 DNA methylase; Region: N6_N4_Mtase; pfam01555
194439004645 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
194439004646 putative active site [active]
194439004647 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
194439004648 Sulfite exporter TauE/SafE; Region: TauE; pfam01925
194439004649 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
194439004650 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
194439004651 Cytochrome c; Region: Cytochrom_C; pfam00034
194439004652 Protein of unknown function (DUF2023); Region: DUF2023; pfam09633
194439004653 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224
194439004654 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
194439004655 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
194439004656 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742
194439004657 FeoA domain; Region: FeoA; pfam04023
194439004658 flavodoxin, long chain; Region: flav_long; TIGR01752
194439004659 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
194439004660 Ferritin-like domain; Region: Ferritin; pfam00210
194439004661 ferroxidase diiron center [ion binding]; other site
194439004662 FeoC like transcriptional regulator; Region: FeoC; pfam09012
194439004663 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
194439004664 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
194439004665 G1 box; other site
194439004666 GTP/Mg2+ binding site [chemical binding]; other site
194439004667 Switch I region; other site
194439004668 G2 box; other site
194439004669 G3 box; other site
194439004670 Switch II region; other site
194439004671 G4 box; other site
194439004672 G5 box; other site
194439004673 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; cl09932
194439004674 Nucleoside recognition; Region: Gate; pfam07670
194439004675 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
194439004676 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
194439004677 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
194439004678 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
194439004679 peroxiredoxin; Provisional; Region: PRK13189
194439004680 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
194439004681 dimer interface [polypeptide binding]; other site
194439004682 decamer (pentamer of dimers) interface [polypeptide binding]; other site
194439004683 catalytic triad [active]
194439004684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
194439004685 S-adenosylmethionine binding site [chemical binding]; other site
194439004686 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
194439004687 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
194439004688 FeS/SAM binding site; other site
194439004689 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
194439004690 PEP-CTERM motif; Region: VPEP; pfam07589
194439004691 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
194439004692 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
194439004693 Moco binding site; other site
194439004694 metal coordination site [ion binding]; other site
194439004695 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
194439004696 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
194439004697 N-terminal plug; other site
194439004698 ligand-binding site [chemical binding]; other site
194439004699 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
194439004700 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
194439004701 Walker A/P-loop; other site
194439004702 ATP binding site [chemical binding]; other site
194439004703 Q-loop/lid; other site
194439004704 ABC transporter signature motif; other site
194439004705 Walker B; other site
194439004706 D-loop; other site
194439004707 H-loop/switch region; other site
194439004708 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
194439004709 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
194439004710 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
194439004711 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142
194439004712 putative ligand binding residues [chemical binding]; other site
194439004713 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
194439004714 S-adenosylmethionine binding site [chemical binding]; other site
194439004715 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
194439004716 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
194439004717 Walker A/P-loop; other site
194439004718 ATP binding site [chemical binding]; other site
194439004719 Q-loop/lid; other site
194439004720 ABC transporter signature motif; other site
194439004721 Walker B; other site
194439004722 D-loop; other site
194439004723 H-loop/switch region; other site
194439004724 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
194439004725 ABC-ATPase subunit interface; other site
194439004726 dimer interface [polypeptide binding]; other site
194439004727 putative PBP binding regions; other site
194439004728 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
194439004729 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
194439004730 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
194439004731 active site
194439004732 homodimer interface [polypeptide binding]; other site
194439004733 SAM binding site [chemical binding]; other site
194439004734 TOBE domain; Region: TOBE; cl01440
194439004735 TOBE domain; Region: TOBE; cl01440
194439004736 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
194439004737 classical (c) SDRs; Region: SDR_c; cd05233
194439004738 NAD(P) binding site [chemical binding]; other site
194439004739 active site
194439004740 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
194439004741 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
194439004742 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172
194439004743 Lipopolysaccharide-assembly; Region: LptE; pfam04390
194439004744 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
194439004745 classical (c) SDRs; Region: SDR_c; cd05233
194439004746 NAD(P) binding site [chemical binding]; other site
194439004747 active site
194439004748 Ribulose bisphosphate carboxylase like proteins from phototrophic bacteria; Region: RLP_Photo; cd08208
194439004749 ribulose bisphosphate carboxylase, type III; Region: rubisco_III; TIGR03326
194439004750 dimer interface [polypeptide binding]; other site
194439004751 active site
194439004752 catalytic residue [active]
194439004753 metal binding site [ion binding]; metal-binding site
194439004754 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
194439004755 putative active site; other site
194439004756 catalytic residue [active]
194439004757 short chain dehydrogenase; Validated; Region: PRK08324
194439004758 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
194439004759 active site
194439004760 Zn2+ binding site [ion binding]; other site
194439004761 intersubunit interface [polypeptide binding]; other site
194439004762 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943
194439004763 putative NAD(P) binding site [chemical binding]; other site
194439004764 active site
194439004765 2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284
194439004766 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
194439004767 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
194439004768 Radical SAM superfamily; Region: Radical_SAM; pfam04055
194439004769 FeS/SAM binding site; other site
194439004770 recombination regulator RecX; Reviewed; Region: recX; PRK00117
194439004771 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
194439004772 putative nucleotide binding site [chemical binding]; other site
194439004773 uridine monophosphate binding site [chemical binding]; other site
194439004774 homohexameric interface [polypeptide binding]; other site
194439004775 elongation factor Ts; Provisional; Region: tsf; PRK09377
194439004776 UBA/TS-N domain; Region: UBA; pfam00627
194439004777 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
194439004778 rRNA interaction site [nucleotide binding]; other site
194439004779 S8 interaction site; other site
194439004780 putative laminin-1 binding site; other site
194439004781 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
194439004782 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
194439004783 23S rRNA interface [nucleotide binding]; other site
194439004784 L3 interface [polypeptide binding]; other site
194439004785 GTP-binding protein Der; Reviewed; Region: PRK00093
194439004786 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
194439004787 G1 box; other site
194439004788 GTP/Mg2+ binding site [chemical binding]; other site
194439004789 Switch I region; other site
194439004790 G2 box; other site
194439004791 Switch II region; other site
194439004792 G3 box; other site
194439004793 G4 box; other site
194439004794 G5 box; other site
194439004795 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
194439004796 G1 box; other site
194439004797 GTP/Mg2+ binding site [chemical binding]; other site
194439004798 Switch I region; other site
194439004799 G2 box; other site
194439004800 G3 box; other site
194439004801 Switch II region; other site
194439004802 G4 box; other site
194439004803 G5 box; other site
194439004804 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714
194439004805 Domain of unknown function DUF59; Region: DUF59; pfam01883
194439004806 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969
194439004807 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
194439004808 Walker A motif; other site
194439004809 NifU-like domain; Region: NifU; cl00484
194439004810 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
194439004811 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
194439004812 rRNA processing; Region: rRNA_processing; pfam08524
194439004813 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
194439004814 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
194439004815 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
194439004816 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
194439004817 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
194439004818 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
194439004819 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
194439004820 dimerization interface [polypeptide binding]; other site
194439004821 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
194439004822 ATP binding site [chemical binding]; other site
194439004823 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
194439004824 Sel1-like repeats; Region: SEL1; smart00671
194439004825 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
194439004826 HupF/HypC family; Region: HupF_HypC; pfam01455
194439004827 23S rRNA-intervening sequence protein; Region: 23S_rRNA_IVP; cl05287
194439004828 Acylphosphatase; Region: Acylphosphatase; pfam00708
194439004829 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
194439004830 HypF finger; Region: zf-HYPF; pfam07503
194439004831 HypF finger; Region: zf-HYPF; pfam07503
194439004832 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
194439004833 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
194439004834 G1 box; other site
194439004835 GTP/Mg2+ binding site [chemical binding]; other site
194439004836 G2 box; other site
194439004837 Switch I region; other site
194439004838 G3 box; other site
194439004839 Switch II region; other site
194439004840 G4 box; other site
194439004841 G5 box; other site
194439004842 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
194439004843 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
194439004844 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
194439004845 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
194439004846 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727
194439004847 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
194439004848 nudix motif; other site
194439004849 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
194439004850 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
194439004851 Na binding site [ion binding]; other site
194439004852 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14671
194439004853 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
194439004854 GIY-YIG motif/motif A; other site
194439004855 active site
194439004856 catalytic site [active]
194439004857 putative DNA binding site [nucleotide binding]; other site
194439004858 metal binding site [ion binding]; metal-binding site
194439004859 UvrB/uvrC motif; Region: UVR; pfam02151
194439004860 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
194439004861 Helix-hairpin-helix motif; Region: HHH_2; pfam12826
194439004862 DNA binding site [nucleotide binding]
194439004863 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
194439004864 binding surface
194439004865 TPR motif; other site
194439004866 TPR repeat; Region: TPR_11; pfam13414
194439004867 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
194439004868 binding surface
194439004869 TPR motif; other site
194439004870 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
194439004871 binding surface
194439004872 Tetratricopeptide repeat; Region: TPR_16; pfam13432
194439004873 TPR motif; other site
194439004874 TPR repeat; Region: TPR_11; pfam13414
194439004875 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
194439004876 binding surface
194439004877 TPR motif; other site
194439004878 TPR repeat; Region: TPR_11; pfam13414
194439004879 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
194439004880 binding surface
194439004881 Tetratricopeptide repeat; Region: TPR_16; pfam13432
194439004882 TPR motif; other site
194439004883 TPR repeat; Region: TPR_11; pfam13414
194439004884 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
194439004885 binding surface
194439004886 TPR motif; other site
194439004887 TPR repeat; Region: TPR_11; pfam13414
194439004888 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
194439004889 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
194439004890 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
194439004891 shikimate binding site; other site
194439004892 NAD(P) binding site [chemical binding]; other site
194439004893 lipoprotein signal peptidase; Provisional; Region: PRK14787
194439004894 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
194439004895 active site
194439004896 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
194439004897 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
194439004898 active site
194439004899 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
194439004900 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
194439004901 catalytic residue [active]
194439004902 purine nucleoside phosphorylase; Provisional; Region: PRK08202
194439004903 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005
194439004904 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
194439004905 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
194439004906 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
194439004907 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
194439004908 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
194439004909 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
194439004910 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
194439004911 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
194439004912 Walker A/P-loop; other site
194439004913 ATP binding site [chemical binding]; other site
194439004914 Q-loop/lid; other site
194439004915 ABC transporter signature motif; other site
194439004916 Walker B; other site
194439004917 D-loop; other site
194439004918 H-loop/switch region; other site
194439004919 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
194439004920 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
194439004921 Walker A/P-loop; other site
194439004922 ATP binding site [chemical binding]; other site
194439004923 Q-loop/lid; other site
194439004924 ABC transporter signature motif; other site
194439004925 Walker B; other site
194439004926 D-loop; other site
194439004927 H-loop/switch region; other site
194439004928 Lipocalin-like domain; Region: Lipocalin_2; cl19222
194439004929 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
194439004930 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
194439004931 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
194439004932 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
194439004933 putative active site [active]
194439004934 putative substrate binding site [chemical binding]; other site
194439004935 putative cosubstrate binding site; other site
194439004936 catalytic site [active]
194439004937 chlorophyllide reductase subunit Y; Region: BchY; TIGR02015
194439004938 DNA sequence specific (IHF) and non-specific (HU) domains; Region: HU_IHF; cl00257
194439004939 dimer interface [polypeptide binding]; other site
194439004940 Sporulation related domain; Region: SPOR; pfam05036
194439004941 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
194439004942 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
194439004943 generic binding surface II; other site
194439004944 generic binding surface I; other site
194439004945 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
194439004946 Protein of unknown function (DUF3348); Region: DUF3348; pfam11828
194439004947 Sulfite exporter TauE/SafE; Region: TauE; pfam01925
194439004948 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
194439004949 Ligand binding site; other site
194439004950 oligomer interface; other site
194439004951 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
194439004952 putative active site [active]
194439004953 dimerization interface [polypeptide binding]; other site
194439004954 putative tRNAtyr binding site [nucleotide binding]; other site
194439004955 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
194439004956 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
194439004957 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
194439004958 Chloroflexus aurantiacus (Ca) citrate synthase (CS)_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). This group is...; Region: CaCS_like; cd06116
194439004959 dimer interface [polypeptide binding]; other site
194439004960 active site
194439004961 citrylCoA binding site [chemical binding]; other site
194439004962 oxalacetate/citrate binding site [chemical binding]; other site
194439004963 coenzyme A binding site [chemical binding]; other site
194439004964 catalytic triad [active]
194439004965 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
194439004966 metal-binding site [ion binding]
194439004967 TPR repeat; Region: TPR_11; pfam13414
194439004968 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
194439004969 binding surface
194439004970 TPR motif; other site
194439004971 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
194439004972 salicylate biosynthesis isochorismate synthase; Validated; Region: PRK07054
194439004973 isochorismate synthases; Region: isochor_syn; TIGR00543
194439004974 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173
194439004975 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
194439004976 dimer interface [polypeptide binding]; other site
194439004977 tetramer interface [polypeptide binding]; other site
194439004978 PYR/PP interface [polypeptide binding]; other site
194439004979 TPP binding site [chemical binding]; other site
194439004980 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
194439004981 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
194439004982 TPP-binding site; other site
194439004983 DinB family; Region: DinB; cl17821
194439004984 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477
194439004985 Acetyltransferases [General function prediction only]; Region: RimI; COG0456
194439004986 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
194439004987 Coenzyme A binding pocket [chemical binding]; other site
194439004988 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
194439004989 Putative lysophospholipase; Region: Hydrolase_4; cl19140
194439004990 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396
194439004991 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
194439004992 substrate binding site [chemical binding]; other site
194439004993 oxyanion hole (OAH) forming residues; other site
194439004994 trimer interface [polypeptide binding]; other site
194439004995 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
194439004996 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927
194439004997 active site
194439004998 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
194439004999 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923
194439005000 acyl-activating enzyme (AAE) consensus motif; other site
194439005001 putative AMP binding site [chemical binding]; other site
194439005002 putative active site [active]
194439005003 putative CoA binding site [chemical binding]; other site
194439005004 dihydrodipicolinate reductase; Provisional; Region: PRK00048
194439005005 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
194439005006 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
194439005007 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
194439005008 ParB-like nuclease domain; Region: ParB; smart00470
194439005009 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
194439005010 KorB domain; Region: KorB; pfam08535
194439005011 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
194439005012 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
194439005013 P-loop; other site
194439005014 Magnesium ion binding site [ion binding]; other site
194439005015 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
194439005016 active site
194439005017 DNA binding site [nucleotide binding]
194439005018 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
194439005019 MgtE intracellular N domain; Region: MgtE_N; pfam03448
194439005020 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
194439005021 Divalent cation transporter; Region: MgtE; pfam01769
194439005022 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
194439005023 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
194439005024 Ligand Binding Site [chemical binding]; other site
194439005025 Predicted esterase [General function prediction only]; Region: COG0400
194439005026 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
194439005027 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
194439005028 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
194439005029 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740
194439005030 substrate binding pocket [chemical binding]; other site
194439005031 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
194439005032 B12 binding site [chemical binding]; other site
194439005033 cobalt ligand [ion binding]; other site
194439005034 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
194439005035 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
194439005036 hydrophobic ligand binding site; other site
194439005037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
194439005038 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
194439005039 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
194439005040 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
194439005041 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
194439005042 Protein of unknown function (DUF541); Region: SIMPL; pfam04402
194439005043 Uncharacterized conserved protein (DUF2278); Region: DUF2278; cl17857
194439005044 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
194439005045 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
194439005046 TPP-binding site [chemical binding]; other site
194439005047 dimer interface [polypeptide binding]; other site
194439005048 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
194439005049 PYR/PP interface [polypeptide binding]; other site
194439005050 dimer interface [polypeptide binding]; other site
194439005051 TPP binding site [chemical binding]; other site
194439005052 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
194439005053 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
194439005054 putative active site [active]
194439005055 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
194439005056 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
194439005057 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
194439005058 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
194439005059 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
194439005060 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
194439005061 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
194439005062 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
194439005063 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
194439005064 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
194439005065 ATP binding site [chemical binding]; other site
194439005066 putative Mg++ binding site [ion binding]; other site
194439005067 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008
194439005068 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
194439005069 putative active site [active]
194439005070 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
194439005071 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
194439005072 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
194439005073 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
194439005074 HsdM N-terminal domain; Region: HsdM_N; pfam12161
194439005075 Methyltransferase domain; Region: Methyltransf_26; pfam13659
194439005076 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
194439005077 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
194439005078 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
194439005079 putative deacylase active site [active]
194439005080 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
194439005081 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
194439005082 active site
194439005083 nucleophile elbow; other site
194439005084 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087
194439005085 NAD(P) binding site [chemical binding]; other site
194439005086 catalytic residues [active]
194439005087 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
194439005088 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
194439005089 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
194439005090 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
194439005091 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
194439005092 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
194439005093 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055
194439005094 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345
194439005095 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
194439005096 FAD binding pocket [chemical binding]; other site
194439005097 FAD binding motif [chemical binding]; other site
194439005098 phosphate binding motif [ion binding]; other site
194439005099 beta-alpha-beta structure motif; other site
194439005100 NAD binding pocket [chemical binding]; other site
194439005101 Iron coordination center [ion binding]; other site
194439005102 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
194439005103 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
194439005104 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
194439005105 active site
194439005106 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
194439005107 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
194439005108 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
194439005109 Mechanosensitive ion channel; Region: MS_channel; pfam00924
194439005110 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232
194439005111 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
194439005112 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
194439005113 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
194439005114 trimer interface [polypeptide binding]; other site
194439005115 putative metal binding site [ion binding]; other site
194439005116 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
194439005117 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
194439005118 Walker A/P-loop; other site
194439005119 ATP binding site [chemical binding]; other site
194439005120 Q-loop/lid; other site
194439005121 ABC transporter signature motif; other site
194439005122 Walker B; other site
194439005123 D-loop; other site
194439005124 H-loop/switch region; other site
194439005125 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
194439005126 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
194439005127 B12 binding site [chemical binding]; other site
194439005128 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
194439005129 FeS/SAM binding site; other site
194439005130 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
194439005131 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
194439005132 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
194439005133 Zn2+ binding site [ion binding]; other site
194439005134 Mg2+ binding site [ion binding]; other site
194439005135 YtxH-like protein; Region: YtxH; pfam12732
194439005136 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
194439005137 Putative lysophospholipase; Region: Hydrolase_4; cl19140
194439005138 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
194439005139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
194439005140 S-adenosylmethionine binding site [chemical binding]; other site
194439005141 phosphoethanolamine transferase; Provisional; Region: PRK11560
194439005142 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
194439005143 NurA domain; Region: NurA; pfam09376
194439005144 Domain of unknown function DUF87; Region: DUF87; cl19135
194439005145 HerA helicase [Replication, recombination, and repair]; Region: COG0433
194439005146 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
194439005147 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
194439005148 hinge; other site
194439005149 active site
194439005150 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
194439005151 cystathionine beta-synthase; Region: cysta_beta; TIGR01137
194439005152 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
194439005153 dimer interface [polypeptide binding]; other site
194439005154 pyridoxal 5'-phosphate binding site [chemical binding]; other site
194439005155 catalytic residue [active]
194439005156 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
194439005157 alanine racemase; Reviewed; Region: alr; PRK00053
194439005158 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
194439005159 active site
194439005160 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
194439005161 dimer interface [polypeptide binding]; other site
194439005162 substrate binding site [chemical binding]; other site
194439005163 catalytic residues [active]
194439005164 comEA protein; Region: comE; TIGR01259
194439005165 Helix-hairpin-helix motif; Region: HHH_3; pfam12836
194439005166 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
194439005167 zinc-finger of transposase IS204/IS1001/IS1096/IS1165; Region: zf-ISL3; pfam14690
194439005168 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
194439005169 Transposase; Region: DDE_Tnp_ISL3; pfam01610
194439005170 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
194439005171 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
194439005172 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
194439005173 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118
194439005174 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774
194439005175 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
194439005176 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
194439005177 FMN binding site [chemical binding]; other site
194439005178 active site
194439005179 catalytic residues [active]
194439005180 substrate binding site [chemical binding]; other site
194439005181 recombinase A; Provisional; Region: recA; PRK09354
194439005182 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
194439005183 hexamer interface [polypeptide binding]; other site
194439005184 Walker A motif; other site
194439005185 ATP binding site [chemical binding]; other site
194439005186 Walker B motif; other site
194439005187 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
194439005188 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
194439005189 putative NADP binding site [chemical binding]; other site
194439005190 putative substrate binding site [chemical binding]; other site
194439005191 active site
194439005192 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
194439005193 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
194439005194 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
194439005195 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697
194439005196 trigger factor; Region: tig; TIGR00115
194439005197 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
194439005198 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
194439005199 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
194439005200 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
194439005201 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
194439005202 dimerization interface [polypeptide binding]; other site
194439005203 active site
194439005204 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263
194439005205 active site
194439005206 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
194439005207 catalytic center binding site [active]
194439005208 ATP binding site [chemical binding]; other site
194439005209 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
194439005210 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
194439005211 P loop; other site
194439005212 Nucleotide binding site [chemical binding]; other site
194439005213 DTAP/Switch II; other site
194439005214 Switch I; other site
194439005215 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298
194439005216 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108
194439005217 DNA polymerase subunit Cdc27; Region: CDC27; pfam09507
194439005218 Bacteriochlorophyll C binding protein; Region: Bac_chlorC; pfam02043
194439005219 Chlorosome envelope protein C; Region: Chlorosome_CsmC; pfam11098
194439005220 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
194439005221 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
194439005222 P loop; other site
194439005223 Nucleotide binding site [chemical binding]; other site
194439005224 DTAP/Switch II; other site
194439005225 Switch I; other site
194439005226 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
194439005227 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
194439005228 FAD binding pocket [chemical binding]; other site
194439005229 FAD binding motif [chemical binding]; other site
194439005230 phosphate binding motif [ion binding]; other site
194439005231 beta-alpha-beta structure motif; other site
194439005232 NAD binding pocket [chemical binding]; other site
194439005233 Iron coordination center [ion binding]; other site
194439005234 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
194439005235 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
194439005236 dimer interface [polypeptide binding]; other site
194439005237 ssDNA binding site [nucleotide binding]; other site
194439005238 tetramer (dimer of dimers) interface [polypeptide binding]; other site
194439005239 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912
194439005240 DNA polymerase III, delta subunit; Region: holA; TIGR01128
194439005241 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
194439005242 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
194439005243 NAD(P) binding site [chemical binding]; other site
194439005244 active site
194439005245 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858
194439005246 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
194439005247 substrate-cofactor binding pocket; other site
194439005248 pyridoxal 5'-phosphate binding site [chemical binding]; other site
194439005249 catalytic residue [active]
194439005250 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715
194439005251 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
194439005252 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
194439005253 N-terminal plug; other site
194439005254 ligand-binding site [chemical binding]; other site
194439005255 magnesium chelatase, H subunit; Region: BchH; TIGR02025
194439005256 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
194439005257 magnesium chelatase subunit H; Provisional; Region: PRK12493
194439005258 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965
194439005259 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
194439005260 Protein of unknown function DUF72; Region: DUF72; cl00777
194439005261 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
194439005262 S-adenosylmethionine binding site [chemical binding]; other site
194439005263 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109
194439005264 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026
194439005265 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
194439005266 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
194439005267 FeS/SAM binding site; other site
194439005268 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
194439005269 catalytic tetrad [active]
194439005270 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
194439005271 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
194439005272 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
194439005273 enolase; Provisional; Region: eno; PRK00077
194439005274 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
194439005275 dimer interface [polypeptide binding]; other site
194439005276 metal binding site [ion binding]; metal-binding site
194439005277 substrate binding pocket [chemical binding]; other site
194439005278 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
194439005279 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
194439005280 transmembrane helices; other site
194439005281 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
194439005282 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
194439005283 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
194439005284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
194439005285 S-adenosylmethionine binding site [chemical binding]; other site
194439005286 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
194439005287 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
194439005288 putative dimer interface [polypeptide binding]; other site
194439005289 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
194439005290 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
194439005291 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639
194439005292 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669
194439005293 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670
194439005294 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09664
194439005295 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646
194439005296 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756
194439005297 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719
194439005298 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648
194439005299 Domain of unknown function (DUF4438); Region: DUF4438; pfam14505
194439005300 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
194439005301 Peptidase family M23; Region: Peptidase_M23; pfam01551
194439005302 hypothetical protein; Provisional; Region: PRK09256
194439005303 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
194439005304 FOG: WD40 repeat [General function prediction only]; Region: COG2319
194439005305 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
194439005306 structural tetrad; other site
194439005307 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
194439005308 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423
194439005309 DXD motif; other site
194439005310 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
194439005311 ATP phosphoribosyltransferase; Region: hisG; TIGR00070
194439005312 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
194439005313 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
194439005314 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
194439005315 putative active site [active]
194439005316 putative metal binding site [ion binding]; other site
194439005317 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
194439005318 Bacteriochlorophyll/chlorophyll synthetase; Region: PT_UbiA_chlorophyll; cd13958
194439005319 putative active site [active]
194439005320 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14340
194439005321 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
194439005322 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
194439005323 FeS/SAM binding site; other site
194439005324 TRAM domain; Region: TRAM; pfam01938
194439005325 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
194439005326 trimerization site [polypeptide binding]; other site
194439005327 active site
194439005328 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
194439005329 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
194439005330 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
194439005331 catalytic residue [active]
194439005332 Helix-turn-helix domain; Region: HTH_25; pfam13413
194439005333 Domain of unknown function DUF21; Region: DUF21; pfam01595
194439005334 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
194439005335 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
194439005336 Transporter associated domain; Region: CorC_HlyC; smart01091
194439005337 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
194439005338 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
194439005339 catalytic triad [active]
194439005340 Nucleoside diphosphate kinase; Region: NDK; pfam00334
194439005341 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
194439005342 active site
194439005343 multimer interface [polypeptide binding]; other site
194439005344 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
194439005345 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
194439005346 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
194439005347 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
194439005348 active site
194439005349 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
194439005350 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
194439005351 nucleotide binding site [chemical binding]; other site
194439005352 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
194439005353 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
194439005354 active site
194439005355 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028
194439005356 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
194439005357 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
194439005358 FeS/SAM binding site; other site
194439005359 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
194439005360 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
194439005361 active site
194439005362 motif I; other site
194439005363 motif II; other site
194439005364 glycogen synthase; Provisional; Region: PRK14098
194439005365 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
194439005366 ADP-binding pocket [chemical binding]; other site
194439005367 homodimer interface [polypeptide binding]; other site
194439005368 Bacterial Ig-like domain; Region: Big_5; pfam13205
194439005369 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
194439005370 Bacterial Ig-like domain; Region: Big_5; pfam13205
194439005371 bacteriochlorophyll 4-vinyl reductase; Region: BchJ; TIGR02019
194439005372 mechanosensitive channel MscS; Provisional; Region: PRK10334
194439005373 Mechanosensitive ion channel; Region: MS_channel; pfam00924
194439005374 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
194439005375 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
194439005376 Ligand binding site; other site
194439005377 Putative Catalytic site; other site
194439005378 DXD motif; other site
194439005379 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
194439005380 Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224
194439005381 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
194439005382 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724
194439005383 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724
194439005384 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180
194439005385 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
194439005386 FeS/SAM binding site; other site
194439005387 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
194439005388 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812
194439005389 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
194439005390 NAD(P) binding site [chemical binding]; other site
194439005391 Rubredoxin [Energy production and conversion]; Region: COG1773
194439005392 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
194439005393 iron binding site [ion binding]; other site
194439005394 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
194439005395 Transglycosylase; Region: Transgly; cl19357
194439005396 Cytochrome c; Region: Cytochrom_C; cl11414
194439005397 Cytochrome c; Region: Cytochrom_C; pfam00034
194439005398 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
194439005399 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
194439005400 ATP binding site [chemical binding]; other site
194439005401 Mg2+ binding site [ion binding]; other site
194439005402 G-X-G motif; other site
194439005403 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
194439005404 ATP binding site [chemical binding]; other site
194439005405 MutL C terminal dimerization domain; Region: MutL_C; pfam08676
194439005406 competence damage-inducible protein A; Provisional; Region: PRK00549
194439005407 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
194439005408 putative MPT binding site; other site
194439005409 Competence-damaged protein; Region: CinA; pfam02464
194439005410 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
194439005411 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
194439005412 putative catalytic residues [active]
194439005413 putative nucleotide binding site [chemical binding]; other site
194439005414 putative aspartate binding site [chemical binding]; other site
194439005415 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
194439005416 dimer interface [polypeptide binding]; other site
194439005417 putative threonine allosteric regulatory site; other site
194439005418 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
194439005419 putative threonine allosteric regulatory site; other site
194439005420 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
194439005421 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
194439005422 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
194439005423 core domain interface [polypeptide binding]; other site
194439005424 delta subunit interface [polypeptide binding]; other site
194439005425 epsilon subunit interface [polypeptide binding]; other site
194439005426 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
194439005427 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
194439005428 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
194439005429 beta subunit interaction interface [polypeptide binding]; other site
194439005430 Walker A motif; other site
194439005431 ATP binding site [chemical binding]; other site
194439005432 Walker B motif; other site
194439005433 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
194439005434 homoserine kinase; Provisional; Region: PRK01212
194439005435 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
194439005436 threonine synthase; Validated; Region: PRK09225
194439005437 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
194439005438 pyridoxal 5'-phosphate binding site [chemical binding]; other site
194439005439 catalytic residue [active]
194439005440 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
194439005441 putative acyl-acceptor binding pocket; other site
194439005442 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
194439005443 homopentamer interface [polypeptide binding]; other site
194439005444 active site
194439005445 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
194439005446 dimer interface [polypeptide binding]; other site
194439005447 active site
194439005448 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
194439005449 substrate binding site [chemical binding]; other site
194439005450 active site
194439005451 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
194439005452 Cysteine-rich domain; Region: CCG; pfam02754
194439005453 Cysteine-rich domain; Region: CCG; pfam02754
194439005454 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479
194439005455 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
194439005456 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
194439005457 catalytic loop [active]
194439005458 iron binding site [ion binding]; other site
194439005459 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
194439005460 L-aspartate oxidase; Provisional; Region: PRK06175
194439005461 succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812
194439005462 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
194439005463 FOG: CBS domain [General function prediction only]; Region: COG0517
194439005464 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
194439005465 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
194439005466 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
194439005467 MMPL family; Region: MMPL; cl14618
194439005468 MMPL family; Region: MMPL; cl14618
194439005469 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
194439005470 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
194439005471 Outer membrane efflux protein; Region: OEP; pfam02321
194439005472 Outer membrane efflux protein; Region: OEP; pfam02321
194439005473 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
194439005474 putative homodimer interface [polypeptide binding]; other site
194439005475 putative homotetramer interface [polypeptide binding]; other site
194439005476 putative allosteric switch controlling residues; other site
194439005477 putative metal binding site [ion binding]; other site
194439005478 putative homodimer-homodimer interface [polypeptide binding]; other site
194439005479 Phosphotransferase enzyme family; Region: APH; pfam01636
194439005480 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
194439005481 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
194439005482 glucose-1-phosphate adenylyltransferase; Region: glgC; TIGR02091
194439005483 Substrate binding site; other site
194439005484 metal-binding site
194439005485 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
194439005486 putative trimer interface [polypeptide binding]; other site
194439005487 putative CoA binding site [chemical binding]; other site
194439005488 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
194439005489 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493
194439005490 Na binding site [ion binding]; other site
194439005491 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
194439005492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
194439005493 active site
194439005494 phosphorylation site [posttranslational modification]
194439005495 intermolecular recognition site; other site
194439005496 dimerization interface [polypeptide binding]; other site
194439005497 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
194439005498 PAS fold; Region: PAS_3; pfam08447
194439005499 putative active site [active]
194439005500 heme pocket [chemical binding]; other site
194439005501 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
194439005502 heme pocket [chemical binding]; other site
194439005503 PAS fold; Region: PAS_3; pfam08447
194439005504 putative active site [active]
194439005505 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
194439005506 dimer interface [polypeptide binding]; other site
194439005507 phosphorylation site [posttranslational modification]
194439005508 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
194439005509 ATP binding site [chemical binding]; other site
194439005510 Mg2+ binding site [ion binding]; other site
194439005511 G-X-G motif; other site
194439005512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
194439005513 active site
194439005514 phosphorylation site [posttranslational modification]
194439005515 intermolecular recognition site; other site
194439005516 dimerization interface [polypeptide binding]; other site
194439005517 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
194439005518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
194439005519 active site
194439005520 phosphorylation site [posttranslational modification]
194439005521 intermolecular recognition site; other site
194439005522 dimerization interface [polypeptide binding]; other site
194439005523 Bacteriochlorophyll C binding protein; Region: Bac_chlorC; pfam02043
194439005524 Arenavirus glycoprotein; Region: Arena_glycoprot; pfam00798
194439005525 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
194439005526 NAD(P) binding site [chemical binding]; other site
194439005527 putative active site [active]
194439005528 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
194439005529 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
194439005530 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
194439005531 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
194439005532 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
194439005533 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
194439005534 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
194439005535 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
194439005536 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
194439005537 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
194439005538 P loop; other site
194439005539 Nucleotide binding site [chemical binding]; other site
194439005540 DTAP/Switch II; other site
194439005541 Switch I; other site
194439005542 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
194439005543 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
194439005544 putative active site [active]
194439005545 heme pocket [chemical binding]; other site
194439005546 Integral membrane protein TerC family; Region: TerC; cl10468
194439005547 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
194439005548 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
194439005549 binding surface
194439005550 TPR motif; other site
194439005551 TPR repeat; Region: TPR_11; pfam13414
194439005552 TPR repeat; Region: TPR_11; pfam13414
194439005553 Tetratricopeptide repeat; Region: TPR_1; pfam00515
194439005554 TPR repeat; Region: TPR_11; pfam13414
194439005555 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
194439005556 binding surface
194439005557 TPR motif; other site
194439005558 TPR repeat; Region: TPR_11; pfam13414
194439005559 Tetratricopeptide repeat; Region: TPR_9; pfam13371
194439005560 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
194439005561 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
194439005562 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
194439005563 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
194439005564 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
194439005565 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852
194439005566 Cytochrome c; Region: Cytochrom_C; cl11414
194439005567 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
194439005568 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
194439005569 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
194439005570 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547
194439005571 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
194439005572 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
194439005573 trmE is a tRNA modification GTPase; Region: trmE; cd04164
194439005574 G1 box; other site
194439005575 GTP/Mg2+ binding site [chemical binding]; other site
194439005576 Switch I region; other site
194439005577 G2 box; other site
194439005578 Switch II region; other site
194439005579 G3 box; other site
194439005580 G4 box; other site
194439005581 G5 box; other site
194439005582 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
194439005583 short chain dehydrogenase; Provisional; Region: PRK07326
194439005584 classical (c) SDRs; Region: SDR_c; cd05233
194439005585 NAD(P) binding site [chemical binding]; other site
194439005586 active site
194439005587 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
194439005588 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
194439005589 homodimer interface [polypeptide binding]; other site
194439005590 metal binding site [ion binding]; metal-binding site
194439005591 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
194439005592 homodimer interface [polypeptide binding]; other site
194439005593 active site
194439005594 putative chemical substrate binding site [chemical binding]; other site
194439005595 metal binding site [ion binding]; metal-binding site
194439005596 Predicted esterase [General function prediction only]; Region: COG0400
194439005597 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144
194439005598 trehalose synthase; Region: treS_nterm; TIGR02456
194439005599 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
194439005600 active site
194439005601 catalytic site [active]
194439005602 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
194439005603 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
194439005604 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
194439005605 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
194439005606 active site
194439005607 homodimer interface [polypeptide binding]; other site
194439005608 catalytic site [active]
194439005609 acceptor binding site [chemical binding]; other site
194439005610 Homo sapiens Nbla03831 and related proteins, metallophosphatase domain; Region: MPP_Nbla03831; cd07396
194439005611 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
194439005612 active site
194439005613 metal binding site [ion binding]; metal-binding site
194439005614 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
194439005615 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
194439005616 active site
194439005617 homodimer interface [polypeptide binding]; other site
194439005618 OstA-like protein; Region: OstA; cl00844
194439005619 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
194439005620 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
194439005621 Recombination protein O N terminal; Region: RecO_N; pfam11967
194439005622 Recombination protein O C terminal; Region: RecO_C; pfam02565
194439005623 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
194439005624 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
194439005625 inhibitor-cofactor binding pocket; inhibition site
194439005626 pyridoxal 5'-phosphate binding site [chemical binding]; other site
194439005627 catalytic residue [active]
194439005628 Uncharacterized ACR, COG1993; Region: DUF190; cl00872
194439005629 camphor resistance protein CrcB; Provisional; Region: PRK14202
194439005630 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
194439005631 ABC-ATPase subunit interface; other site
194439005632 dimer interface [polypeptide binding]; other site
194439005633 putative PBP binding regions; other site
194439005634 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
194439005635 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
194439005636 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
194439005637 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018
194439005638 putative metal binding residues [ion binding]; other site
194439005639 2-isopropylmalate synthase; Validated; Region: PRK03739
194439005640 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
194439005641 active site
194439005642 catalytic residues [active]
194439005643 metal binding site [ion binding]; metal-binding site
194439005644 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
194439005645 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
194439005646 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
194439005647 putative phosphate acyltransferase; Provisional; Region: PRK05331
194439005648 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
194439005649 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
194439005650 dimer interface [polypeptide binding]; other site
194439005651 active site
194439005652 CoA binding pocket [chemical binding]; other site
194439005653 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
194439005654 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
194439005655 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
194439005656 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
194439005657 NAD(P) binding site [chemical binding]; other site
194439005658 homotetramer interface [polypeptide binding]; other site
194439005659 homodimer interface [polypeptide binding]; other site
194439005660 active site
194439005661 acyl carrier protein; Provisional; Region: acpP; PRK00982
194439005662 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
194439005663 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
194439005664 dimer interface [polypeptide binding]; other site
194439005665 active site
194439005666 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
194439005667 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
194439005668 dimerization interface [polypeptide binding]; other site
194439005669 active site
194439005670 metal binding site [ion binding]; metal-binding site
194439005671 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
194439005672 dsRNA binding site [nucleotide binding]; other site
194439005673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
194439005674 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
194439005675 S-adenosylmethionine binding site [chemical binding]; other site
194439005676 EcoRII C terminal; Region: EcoRII-C; pfam09019
194439005677 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
194439005678 tetramer interface [polypeptide binding]; other site
194439005679 pyridoxal 5'-phosphate binding site [chemical binding]; other site
194439005680 catalytic residue [active]
194439005681 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
194439005682 Chlide_reductase_Z : Z subunit of chlorophyllide (chlide) reductase (BchZ). Chlide reductase participates in photosynthetic pigment synthesis playing a role in the conversion of chlorophylls(Chl) into bacteriochlorophylls (BChl). Chlide reductase...; Region: Chlide_reductase_Z; cd01982
194439005683 chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014
194439005684 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
194439005685 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
194439005686 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
194439005687 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
194439005688 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
194439005689 active site
194439005690 dimer interface [polypeptide binding]; other site
194439005691 motif 1; other site
194439005692 motif 2; other site
194439005693 motif 3; other site
194439005694 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
194439005695 anticodon binding site; other site
194439005696 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
194439005697 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
194439005698 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
194439005699 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
194439005700 Ribosomal protein L20; Region: Ribosomal_L20; cd07026
194439005701 23S rRNA binding site [nucleotide binding]; other site
194439005702 L21 binding site [polypeptide binding]; other site
194439005703 L13 binding site [polypeptide binding]; other site
194439005704 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
194439005705 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
194439005706 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
194439005707 dimer interface [polypeptide binding]; other site
194439005708 motif 1; other site
194439005709 active site
194439005710 motif 2; other site
194439005711 motif 3; other site
194439005712 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
194439005713 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
194439005714 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
194439005715 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
194439005716 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
194439005717 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
194439005718 dimer interface [polypeptide binding]; other site
194439005719 ssDNA binding site [nucleotide binding]; other site
194439005720 tetramer (dimer of dimers) interface [polypeptide binding]; other site
194439005721 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
194439005722 Exonuclease III [DNA replication, recombination, and repair]; Region: XthA; COG0708
194439005723 putative catalytic site [active]
194439005724 putative metal binding site [ion binding]; other site
194439005725 putative phosphate binding site [ion binding]; other site
194439005726 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
194439005727 putative active site [active]
194439005728 Domain of Unknown Function (DUF3856); Region: DUF3856; pfam12968
194439005729 mobile mystery protein B; Region: mob_myst_B; TIGR02613
194439005730 Fic/DOC family; Region: Fic; pfam02661
194439005731 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
194439005732 active site
194439005733 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
194439005734 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
194439005735 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
194439005736 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
194439005737 Ligand binding site [chemical binding]; other site
194439005738 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
194439005739 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
194439005740 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
194439005741 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
194439005742 active site
194439005743 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
194439005744 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
194439005745 Cysteine-rich domain; Region: CCG; pfam02754
194439005746 Cysteine-rich domain; Region: CCG; pfam02754
194439005747 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185
194439005748 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
194439005749 P-loop; other site
194439005750 light-independent protochlorophyllide reductase, B subunit; Region: DPOR_BchB; TIGR01278
194439005751 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
194439005752 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
194439005753 Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979
194439005754 Domain of unknown function DUF77; Region: DUF77; pfam01910
194439005755 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
194439005756 GDP-binding site [chemical binding]; other site
194439005757 ACT binding site; other site
194439005758 IMP binding site; other site
194439005759 Predicted GTPase [General function prediction only]; Region: COG0218
194439005760 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
194439005761 G1 box; other site
194439005762 GTP/Mg2+ binding site [chemical binding]; other site
194439005763 Switch I region; other site
194439005764 G2 box; other site
194439005765 G3 box; other site
194439005766 Switch II region; other site
194439005767 G4 box; other site
194439005768 G5 box; other site
194439005769 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
194439005770 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
194439005771 Transposase; Region: DDE_Tnp_ISL3; pfam01610
194439005772 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
194439005773 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
194439005774 active site
194439005775 HIGH motif; other site
194439005776 nucleotidyl transferase superfamily; Region: nt_trans; cl00015
194439005777 active site
194439005778 nucleotide binding site [chemical binding]; other site
194439005779 HIGH motif; other site
194439005780 KMSKS motif; other site
194439005781 KMSKS motif; other site
194439005782 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
194439005783 tRNA binding surface [nucleotide binding]; other site
194439005784 anticodon binding site; other site
194439005785 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
194439005786 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
194439005787 Substrate binding site; other site
194439005788 Cupin domain; Region: Cupin_2; cl17218
194439005789 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
194439005790 Methyltransferase domain; Region: Methyltransf_31; pfam13847
194439005791 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
194439005792 S-adenosylmethionine binding site [chemical binding]; other site
194439005793 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
194439005794 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
194439005795 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
194439005796 alphaNTD homodimer interface [polypeptide binding]; other site
194439005797 alphaNTD - beta interaction site [polypeptide binding]; other site
194439005798 alphaNTD - beta' interaction site [polypeptide binding]; other site
194439005799 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
194439005800 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
194439005801 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
194439005802 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
194439005803 RNA binding surface [nucleotide binding]; other site
194439005804 30S ribosomal protein S11; Validated; Region: PRK05309
194439005805 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
194439005806 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
194439005807 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
194439005808 rRNA binding site [nucleotide binding]; other site
194439005809 predicted 30S ribosome binding site; other site
194439005810 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
194439005811 active site
194439005812 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
194439005813 SecY translocase; Region: SecY; pfam00344
194439005814 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
194439005815 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
194439005816 23S rRNA binding site [nucleotide binding]; other site
194439005817 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
194439005818 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
194439005819 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
194439005820 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
194439005821 5S rRNA interface [nucleotide binding]; other site
194439005822 L27 interface [polypeptide binding]; other site
194439005823 23S rRNA interface [nucleotide binding]; other site
194439005824 L5 interface [polypeptide binding]; other site
194439005825 50S ribosomal protein L6; Validated; Region: rplF; PRK05498
194439005826 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
194439005827 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
194439005828 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
194439005829 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
194439005830 50S ribosomal protein L5; Validated; Region: rplE; PRK00010
194439005831 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
194439005832 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
194439005833 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
194439005834 RNA binding site [nucleotide binding]; other site
194439005835 50S ribosomal protein L14; Validated; Region: rplN; PRK05483
194439005836 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
194439005837 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
194439005838 putative translocon interaction site; other site
194439005839 23S rRNA interface [nucleotide binding]; other site
194439005840 signal recognition particle (SRP54) interaction site; other site
194439005841 L23 interface [polypeptide binding]; other site
194439005842 trigger factor interaction site; other site
194439005843 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
194439005844 23S rRNA interface [nucleotide binding]; other site
194439005845 5S rRNA interface [nucleotide binding]; other site
194439005846 putative antibiotic binding site [chemical binding]; other site
194439005847 L25 interface [polypeptide binding]; other site
194439005848 L27 interface [polypeptide binding]; other site
194439005849 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009
194439005850 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412
194439005851 G-X-X-G motif; other site
194439005852 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
194439005853 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
194439005854 putative translocon binding site; other site
194439005855 protein-rRNA interface [nucleotide binding]; other site
194439005856 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
194439005857 50S ribosomal protein L2; Validated; Region: rplB; PRK09374
194439005858 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
194439005859 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
194439005860 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
194439005861 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
194439005862 50S ribosomal protein L3; Validated; Region: rplC; PRK00001
194439005863 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
194439005864 elongation factor Tu; Reviewed; Region: PRK00049
194439005865 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
194439005866 G1 box; other site
194439005867 GEF interaction site [polypeptide binding]; other site
194439005868 GTP/Mg2+ binding site [chemical binding]; other site
194439005869 Switch I region; other site
194439005870 G2 box; other site
194439005871 G3 box; other site
194439005872 Switch II region; other site
194439005873 G4 box; other site
194439005874 G5 box; other site
194439005875 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
194439005876 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
194439005877 Antibiotic Binding Site [chemical binding]; other site
194439005878 elongation factor G; Reviewed; Region: PRK00007
194439005879 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
194439005880 G1 box; other site
194439005881 putative GEF interaction site [polypeptide binding]; other site
194439005882 GTP/Mg2+ binding site [chemical binding]; other site
194439005883 Switch I region; other site
194439005884 G2 box; other site
194439005885 G3 box; other site
194439005886 Switch II region; other site
194439005887 G4 box; other site
194439005888 G5 box; other site
194439005889 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
194439005890 Elongation Factor G, domain II; Region: EFG_II; pfam14492
194439005891 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
194439005892 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
194439005893 30S ribosomal protein S7; Validated; Region: PRK05302
194439005894 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
194439005895 S17 interaction site [polypeptide binding]; other site
194439005896 S8 interaction site; other site
194439005897 16S rRNA interaction site [nucleotide binding]; other site
194439005898 streptomycin interaction site [chemical binding]; other site
194439005899 23S rRNA interaction site [nucleotide binding]; other site
194439005900 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
194439005901 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
194439005902 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
194439005903 Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
194439005904 Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350
194439005905 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
194439005906 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
194439005907 oligomer interface [polypeptide binding]; other site
194439005908 metal binding site [ion binding]; metal-binding site
194439005909 metal binding site [ion binding]; metal-binding site
194439005910 Cl binding site [ion binding]; other site
194439005911 aspartate ring; other site
194439005912 putative hydrophobic gate; other site
194439005913 periplasmic entrance; other site
194439005914 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
194439005915 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158
194439005916 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
194439005917 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
194439005918 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
194439005919 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
194439005920 putative homodimer interface [polypeptide binding]; other site
194439005921 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
194439005922 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
194439005923 Probable Catalytic site; other site
194439005924 metal-binding site
194439005925 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
194439005926 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
194439005927 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
194439005928 dimerization domain swap beta strand [polypeptide binding]; other site
194439005929 regulatory protein interface [polypeptide binding]; other site
194439005930 active site
194439005931 regulatory phosphorylation site [posttranslational modification]; other site
194439005932 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
194439005933 Coenzyme A binding pocket [chemical binding]; other site
194439005934 GTPase CgtA; Reviewed; Region: obgE; PRK12299
194439005935 GTP1/OBG; Region: GTP1_OBG; pfam01018
194439005936 Obg GTPase; Region: Obg; cd01898
194439005937 G1 box; other site
194439005938 GTP/Mg2+ binding site [chemical binding]; other site
194439005939 Switch I region; other site
194439005940 G2 box; other site
194439005941 G3 box; other site
194439005942 Switch II region; other site
194439005943 G4 box; other site
194439005944 G5 box; other site
194439005945 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609
194439005946 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
194439005947 GatB/GatE catalytic domain; Region: GatB_N; pfam02934
194439005948 GatB domain; Region: GatB_Yqey; smart00845
194439005949 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cl01109
194439005950 putative amphipathic alpha helix; other site
194439005951 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
194439005952 putative ADP-ribose binding site [chemical binding]; other site
194439005953 putative active site [active]
194439005954 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803
194439005955 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
194439005956 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
194439005957 substrate binding site [chemical binding]; other site
194439005958 hinge regions; other site
194439005959 ADP binding site [chemical binding]; other site
194439005960 catalytic site [active]
194439005961 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
194439005962 dimerization interface [polypeptide binding]; other site
194439005963 Chorismate mutase type II; Region: CM_2; pfam01817
194439005964 YacP-like NYN domain; Region: NYN_YacP; pfam05991
194439005965 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
194439005966 Dodecin; Region: Dodecin; pfam07311
194439005967 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
194439005968 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
194439005969 active site
194439005970 substrate-binding site [chemical binding]; other site
194439005971 metal-binding site [ion binding]
194439005972 GTP binding site [chemical binding]; other site
194439005973 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
194439005974 catalytic residues [active]
194439005975 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
194439005976 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
194439005977 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
194439005978 alpha subunit interaction interface [polypeptide binding]; other site
194439005979 Walker A motif; other site
194439005980 ATP binding site [chemical binding]; other site
194439005981 Walker B motif; other site
194439005982 inhibitor binding site; inhibition site
194439005983 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
194439005984 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
194439005985 gamma subunit interface [polypeptide binding]; other site
194439005986 epsilon subunit interface [polypeptide binding]; other site
194439005987 LBP interface [polypeptide binding]; other site
194439005988 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
194439005989 dimer interface [polypeptide binding]; other site
194439005990 catalytic triad [active]
194439005991 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617
194439005992 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
194439005993 active site
194439005994 SAM binding site [chemical binding]; other site
194439005995 homodimer interface [polypeptide binding]; other site
194439005996 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
194439005997 active site
194439005998 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
194439005999 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
194439006000 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
194439006001 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
194439006002 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
194439006003 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
194439006004 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
194439006005 Cysteine-rich domain; Region: CCG; pfam02754
194439006006 MAC/Perforin domain; Region: MACPF; cl02616
194439006007 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
194439006008 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
194439006009 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
194439006010 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102
194439006011 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
194439006012 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
194439006013 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
194439006014 sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064
194439006015 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
194439006016 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
194439006017 DsrC like protein; Region: DsrC; pfam04358
194439006018 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
194439006019 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
194439006020 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
194439006021 catalytic triad [active]
194439006022 Domain of unknown function (DUF955); Region: DUF955; cl01076
194439006023 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367
194439006024 glycyl-tRNA synthetase; Provisional; Region: PRK04173
194439006025 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
194439006026 dimer interface [polypeptide binding]; other site
194439006027 motif 1; other site
194439006028 active site
194439006029 motif 2; other site
194439006030 motif 3; other site
194439006031 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
194439006032 anticodon binding site; other site
194439006033 geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023
194439006034 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
194439006035 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693
194439006036 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159
194439006037 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
194439006038 C-terminal peptidase (prc); Region: prc; TIGR00225
194439006039 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
194439006040 protein binding site [polypeptide binding]; other site
194439006041 Catalytic dyad [active]
194439006042 Tetrahydrodipicolinate N-succinyltransferase N-terminal; Region: THDPS_N_2; pfam14805
194439006043 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
194439006044 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
194439006045 trimer interface [polypeptide binding]; other site
194439006046 active site
194439006047 substrate binding site [chemical binding]; other site
194439006048 CoA binding site [chemical binding]; other site
194439006049 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
194439006050 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
194439006051 homodimer interface [polypeptide binding]; other site
194439006052 oligonucleotide binding site [chemical binding]; other site
194439006053 Ribonuclease E/G family; Region: RNase_E_G; pfam10150
194439006054 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
194439006055 RNA/DNA hybrid binding site [nucleotide binding]; other site
194439006056 active site
194439006057 hypothetical protein; Reviewed; Region: PRK12497
194439006058 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
194439006059 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
194439006060 ATP binding site [chemical binding]; other site
194439006061 Mg2+ binding site [ion binding]; other site
194439006062 G-X-G motif; other site
194439006063 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
194439006064 anchoring element; other site
194439006065 dimer interface [polypeptide binding]; other site
194439006066 ATP binding site [chemical binding]; other site
194439006067 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
194439006068 active site
194439006069 putative metal-binding site [ion binding]; other site
194439006070 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
194439006071 SurA N-terminal domain; Region: SurA_N_3; cl07813
194439006072 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
194439006073 PPIC-type PPIASE domain; Region: Rotamase; pfam00639
194439006074 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
194439006075 PPIC-type PPIASE domain; Region: Rotamase; pfam00639
194439006076 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
194439006077 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
194439006078 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
194439006079 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
194439006080 L-aspartate oxidase; Provisional; Region: PRK06175
194439006081 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
194439006082 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
194439006083 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
194439006084 putative Iron-sulfur protein interface [polypeptide binding]; other site
194439006085 proximal heme binding site [chemical binding]; other site
194439006086 distal heme binding site [chemical binding]; other site
194439006087 putative dimer interface [polypeptide binding]; other site
194439006088 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
194439006089 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
194439006090 Esterase/lipase [General function prediction only]; Region: COG1647
194439006091 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
194439006092 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
194439006093 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
194439006094 hypothetical protein; Provisional; Region: PRK10396
194439006095 yecA family protein; Region: ygfB_yecA; TIGR02292
194439006096 SEC-C motif; Region: SEC-C; cl19389
194439006097 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
194439006098 Coenzyme A binding pocket [chemical binding]; other site
194439006099 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
194439006100 metal ion-dependent adhesion site (MIDAS); other site
194439006101 von Willebrand factor type A domain; Region: VWA_2; pfam13519
194439006102 metal ion-dependent adhesion site (MIDAS); other site
194439006103 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
194439006104 Clp amino terminal domain; Region: Clp_N; pfam02861
194439006105 Clp amino terminal domain; Region: Clp_N; pfam02861
194439006106 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
194439006107 ATPases associated with a variety of cellular activities; Region: AAA; smart00382
194439006108 Walker A motif; other site
194439006109 ATP binding site [chemical binding]; other site
194439006110 Walker B motif; other site
194439006111 arginine finger; other site
194439006112 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
194439006113 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134
194439006114 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
194439006115 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
194439006116 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like2_exo; cd05785
194439006117 DNA polymerase type-B family; Region: POLBc; smart00486
194439006118 active site
194439006119 catalytic site [active]
194439006120 substrate binding site [chemical binding]; other site
194439006121 DNA polymerase type-II B subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II_B; cd05538
194439006122 active site
194439006123 metal-binding site
194439006124 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
194439006125 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
194439006126 NADPH-dependent FMN reductase; Region: FMN_red; cl00438
194439006127 Protein of unknown function (DUF721); Region: DUF721; pfam05258
194439006128 recombination protein F; Reviewed; Region: recF; PRK00064
194439006129 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
194439006130 Walker A/P-loop; other site
194439006131 ATP binding site [chemical binding]; other site
194439006132 Q-loop/lid; other site
194439006133 ABC transporter signature motif; other site
194439006134 Walker B; other site
194439006135 D-loop; other site
194439006136 H-loop/switch region; other site