-- dump date 20140619_041528 -- class Genbank::misc_feature -- table misc_feature_note -- id note 480224000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 480224000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 480224000003 Walker A motif; other site 480224000004 ATP binding site [chemical binding]; other site 480224000005 Walker B motif; other site 480224000006 arginine finger; other site 480224000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 480224000008 DnaA box-binding interface [nucleotide binding]; other site 480224000009 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 480224000010 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 480224000011 acyl-activating enzyme (AAE) consensus motif; other site 480224000012 putative AMP binding site [chemical binding]; other site 480224000013 putative active site [active] 480224000014 putative CoA binding site [chemical binding]; other site 480224000015 acetyl-CoA synthetase; Provisional; Region: PRK00174 480224000016 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 480224000017 active site 480224000018 CoA binding site [chemical binding]; other site 480224000019 acyl-activating enzyme (AAE) consensus motif; other site 480224000020 AMP binding site [chemical binding]; other site 480224000021 acetate binding site [chemical binding]; other site 480224000022 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 480224000023 Double zinc ribbon; Region: DZR; pfam12773 480224000024 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 480224000025 Catalytic domain of Protein Kinases; Region: PKc; cd00180 480224000026 active site 480224000027 ATP binding site [chemical binding]; other site 480224000028 substrate binding site [chemical binding]; other site 480224000029 activation loop (A-loop); other site 480224000030 GTPase Era; Reviewed; Region: era; PRK00089 480224000031 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 480224000032 G1 box; other site 480224000033 GTP/Mg2+ binding site [chemical binding]; other site 480224000034 Switch I region; other site 480224000035 G2 box; other site 480224000036 Switch II region; other site 480224000037 G3 box; other site 480224000038 G4 box; other site 480224000039 G5 box; other site 480224000040 KH domain; Region: KH_2; pfam07650 480224000041 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 480224000042 Domain of unknown function DUF20; Region: UPF0118; pfam01594 480224000043 cell division topological specificity factor MinE; Provisional; Region: PRK13991 480224000044 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 480224000045 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 480224000046 Switch I; other site 480224000047 Switch II; other site 480224000048 septum formation inhibitor; Reviewed; Region: minC; PRK00513 480224000049 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 480224000050 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 480224000051 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 480224000052 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 480224000053 Major Facilitator Superfamily; Region: MFS_1; pfam07690 480224000054 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 480224000055 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 480224000056 DNA binding residues [nucleotide binding] 480224000057 dimer interface [polypeptide binding]; other site 480224000058 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 480224000059 dimerization interface [polypeptide binding]; other site 480224000060 putative DNA binding site [nucleotide binding]; other site 480224000061 putative Zn2+ binding site [ion binding]; other site 480224000062 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 480224000063 Predicted permeases [General function prediction only]; Region: COG0701 480224000064 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 480224000065 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 480224000066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 480224000067 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 480224000068 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 480224000069 dimerization interface [polypeptide binding]; other site 480224000070 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 480224000071 Histidine kinase; Region: HisKA_3; pfam07730 480224000072 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224000073 ATP binding site [chemical binding]; other site 480224000074 Mg2+ binding site [ion binding]; other site 480224000075 G-X-G motif; other site 480224000076 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 480224000077 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224000078 active site 480224000079 phosphorylation site [posttranslational modification] 480224000080 intermolecular recognition site; other site 480224000081 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 480224000082 dimerization interface [polypeptide binding]; other site 480224000083 DNA binding residues [nucleotide binding] 480224000084 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 480224000085 4Fe-4S binding domain; Region: Fer4_6; pfam12837 480224000086 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 480224000087 tetrathionate reductase subunit A; Provisional; Region: PRK14991 480224000088 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 480224000089 molybdopterin cofactor binding site; other site 480224000090 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 480224000091 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 480224000092 putative molybdopterin cofactor binding site; other site 480224000093 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 480224000094 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 480224000095 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 480224000096 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258 480224000097 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 480224000098 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 480224000099 UbiA prenyltransferase family; Region: UbiA; pfam01040 480224000100 Response regulator receiver domain; Region: Response_reg; pfam00072 480224000101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224000102 active site 480224000103 phosphorylation site [posttranslational modification] 480224000104 intermolecular recognition site; other site 480224000105 dimerization interface [polypeptide binding]; other site 480224000106 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 480224000107 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 480224000108 metal binding site [ion binding]; metal-binding site 480224000109 active site 480224000110 I-site; other site 480224000111 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242 480224000112 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 480224000113 putative NAD(P) binding site [chemical binding]; other site 480224000114 catalytic Zn binding site [ion binding]; other site 480224000115 structural Zn binding site [ion binding]; other site 480224000116 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 480224000117 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 480224000118 putative active site [active] 480224000119 substrate binding site [chemical binding]; other site 480224000120 putative cosubstrate binding site; other site 480224000121 catalytic site [active] 480224000122 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 480224000123 substrate binding site [chemical binding]; other site 480224000124 SCP-2 sterol transfer family; Region: SCP2; cl01225 480224000125 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 480224000126 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 480224000127 putative acyl-acceptor binding pocket; other site 480224000128 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 480224000129 Uncharacterized conserved protein [Function unknown]; Region: COG1739 480224000130 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 480224000131 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 480224000132 AAA ATPase domain; Region: AAA_16; pfam13191 480224000133 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 480224000134 DNA binding site [nucleotide binding] 480224000135 Bacterial transcriptional activator domain; Region: BTAD; smart01043 480224000136 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224000137 binding surface 480224000138 TPR motif; other site 480224000139 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 480224000140 tartrate dehydrogenase; Region: TTC; TIGR02089 480224000141 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 480224000142 B12 binding site [chemical binding]; other site 480224000143 cobalt ligand [ion binding]; other site 480224000144 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 480224000145 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 480224000146 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 480224000147 Walker A; other site 480224000148 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 480224000149 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 480224000150 active site 480224000151 substrate binding site [chemical binding]; other site 480224000152 metal binding site [ion binding]; metal-binding site 480224000153 ATP-grasp domain; Region: ATP-grasp_4; cl17255 480224000154 Circularly permuted ATP-grasp type 2; Region: CP_ATPgrasp_2; pfam14403 480224000155 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 480224000156 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 480224000157 intersubunit interface [polypeptide binding]; other site 480224000158 Protein of unknown function, DUF547; Region: DUF547; pfam04784 480224000159 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 480224000160 Methyltransferase domain; Region: Methyltransf_23; pfam13489 480224000161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224000162 S-adenosylmethionine binding site [chemical binding]; other site 480224000163 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 480224000164 active site 480224000165 Uncharacterized conserved protein [Function unknown]; Region: COG1543 480224000166 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 480224000167 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 480224000168 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 480224000169 Catalytic domain of Protein Kinases; Region: PKc; cd00180 480224000170 active site 480224000171 ATP binding site [chemical binding]; other site 480224000172 substrate binding site [chemical binding]; other site 480224000173 activation loop (A-loop); other site 480224000174 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 480224000175 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 480224000176 phosphopeptide binding site; other site 480224000177 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 480224000178 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 480224000179 DNA binding site [nucleotide binding] 480224000180 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 480224000181 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 480224000182 hinge; other site 480224000183 active site 480224000184 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 480224000185 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 480224000186 NAD binding site [chemical binding]; other site 480224000187 homodimer interface [polypeptide binding]; other site 480224000188 active site 480224000189 substrate binding site [chemical binding]; other site 480224000190 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 480224000191 Catalytic domain of Protein Kinases; Region: PKc; cd00180 480224000192 active site 480224000193 ATP binding site [chemical binding]; other site 480224000194 substrate binding site [chemical binding]; other site 480224000195 activation loop (A-loop); other site 480224000196 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 480224000197 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 480224000198 Zn binding sites [ion binding]; other site 480224000199 MoxR-like ATPases [General function prediction only]; Region: COG0714 480224000200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 480224000201 Walker A motif; other site 480224000202 ATP binding site [chemical binding]; other site 480224000203 Walker B motif; other site 480224000204 arginine finger; other site 480224000205 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 480224000206 FtsX-like permease family; Region: FtsX; pfam02687 480224000207 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 480224000208 FtsX-like permease family; Region: FtsX; pfam02687 480224000209 Acyl CoA binding protein; Region: ACBP; pfam00887 480224000210 acyl-CoA binding pocket [chemical binding]; other site 480224000211 CoA binding site [chemical binding]; other site 480224000212 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 480224000213 Peroxiredoxin (PRX) family; composed of the different classes of PRXs including many proteins originally known as bacterioferritin comigratory proteins (BCP), based on their electrophoretic mobility before their function was identified. PRXs are...; Region: PRX_family; cd02971 480224000214 catalytic triad [active] 480224000215 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 480224000216 CRISPR-associated negative auto-regulator DevR/Csa2; Region: DevR; pfam01905 480224000217 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 480224000218 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 480224000219 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 480224000220 Predicted transcriptional regulator [Transcription]; Region: COG2378 480224000221 WYL domain; Region: WYL; pfam13280 480224000222 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 480224000223 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 480224000224 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224000225 CHAT domain; Region: CHAT; pfam12770 480224000226 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 480224000227 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 480224000228 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224000229 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 480224000230 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 480224000231 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 480224000232 Probable Catalytic site; other site 480224000233 metal-binding site 480224000234 Right handed beta helix region; Region: Beta_helix; pfam13229 480224000235 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 480224000236 Bacterial Ig-like domain; Region: Big_5; pfam13205 480224000237 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 480224000238 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 480224000239 transmembrane helices; other site 480224000240 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 480224000241 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 480224000242 active site 480224000243 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 480224000244 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 480224000245 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224000246 Domain of unknown function (DUF309); Region: DUF309; pfam03745 480224000247 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 480224000248 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 480224000249 Walker A motif; other site 480224000250 ATP binding site [chemical binding]; other site 480224000251 Walker B motif; other site 480224000252 arginine finger; other site 480224000253 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 480224000254 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 480224000255 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 480224000256 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 480224000257 substrate binding site [chemical binding]; other site 480224000258 oxyanion hole (OAH) forming residues; other site 480224000259 trimer interface [polypeptide binding]; other site 480224000260 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 480224000261 UbiA prenyltransferase family; Region: UbiA; pfam01040 480224000262 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 480224000263 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 480224000264 acyl-activating enzyme (AAE) consensus motif; other site 480224000265 putative AMP binding site [chemical binding]; other site 480224000266 putative active site [active] 480224000267 putative CoA binding site [chemical binding]; other site 480224000268 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 480224000269 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 480224000270 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 480224000271 trimer interface [polypeptide binding]; other site 480224000272 active site 480224000273 substrate binding site [chemical binding]; other site 480224000274 CoA binding site [chemical binding]; other site 480224000275 Transcriptional regulator [Transcription]; Region: IclR; COG1414 480224000276 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 480224000277 putative DNA binding site [nucleotide binding]; other site 480224000278 putative Zn2+ binding site [ion binding]; other site 480224000279 Bacterial transcriptional regulator; Region: IclR; pfam01614 480224000280 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 480224000281 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 480224000282 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 480224000283 FeoA domain; Region: FeoA; pfam04023 480224000284 enoyl-CoA hydratase; Provisional; Region: PRK05862 480224000285 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 480224000286 substrate binding site [chemical binding]; other site 480224000287 oxyanion hole (OAH) forming residues; other site 480224000288 trimer interface [polypeptide binding]; other site 480224000289 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 480224000290 PAS domain S-box; Region: sensory_box; TIGR00229 480224000291 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224000292 putative active site [active] 480224000293 heme pocket [chemical binding]; other site 480224000294 PAS fold; Region: PAS_4; pfam08448 480224000295 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224000296 putative active site [active] 480224000297 heme pocket [chemical binding]; other site 480224000298 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 480224000299 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224000300 ATP binding site [chemical binding]; other site 480224000301 Mg2+ binding site [ion binding]; other site 480224000302 G-X-G motif; other site 480224000303 Response regulator receiver domain; Region: Response_reg; pfam00072 480224000304 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224000305 active site 480224000306 phosphorylation site [posttranslational modification] 480224000307 intermolecular recognition site; other site 480224000308 dimerization interface [polypeptide binding]; other site 480224000309 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 480224000310 active site 480224000311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 480224000312 putative substrate translocation pore; other site 480224000313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 480224000314 Major Facilitator Superfamily; Region: MFS_1; pfam07690 480224000315 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224000316 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 480224000317 putative ADP-binding pocket [chemical binding]; other site 480224000318 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 480224000319 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 480224000320 Chain length determinant protein; Region: Wzz; cl15801 480224000321 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 480224000322 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 480224000323 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 480224000324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224000325 active site 480224000326 phosphorylation site [posttranslational modification] 480224000327 intermolecular recognition site; other site 480224000328 dimerization interface [polypeptide binding]; other site 480224000329 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 480224000330 DNA binding site [nucleotide binding] 480224000331 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 480224000332 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 480224000333 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 480224000334 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 480224000335 rod shape-determining protein MreC; Provisional; Region: PRK13922 480224000336 rod shape-determining protein MreC; Region: MreC; pfam04085 480224000337 rod shape-determining protein MreB; Provisional; Region: PRK13927 480224000338 MreB and similar proteins; Region: MreB_like; cd10225 480224000339 nucleotide binding site [chemical binding]; other site 480224000340 Mg binding site [ion binding]; other site 480224000341 putative protofilament interaction site [polypeptide binding]; other site 480224000342 RodZ interaction site [polypeptide binding]; other site 480224000343 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 480224000344 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 480224000345 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 480224000346 metal ion-dependent adhesion site (MIDAS); other site 480224000347 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 480224000348 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 480224000349 RNA binding site [nucleotide binding]; other site 480224000350 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 480224000351 RNA binding site [nucleotide binding]; other site 480224000352 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 480224000353 RNA binding site [nucleotide binding]; other site 480224000354 Ribonuclease P; Region: Ribonuclease_P; pfam00825 480224000355 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 480224000356 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 480224000357 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 480224000358 G-X-X-G motif; other site 480224000359 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 480224000360 RxxxH motif; other site 480224000361 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 480224000362 apolar tunnel; other site 480224000363 heme binding site [chemical binding]; other site 480224000364 dimerization interface [polypeptide binding]; other site 480224000365 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 480224000366 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 480224000367 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 480224000368 P loop; other site 480224000369 Nucleotide binding site [chemical binding]; other site 480224000370 DTAP/Switch II; other site 480224000371 Switch I; other site 480224000372 Bacteriochlorophyll C binding protein; Region: Bac_chlorC; pfam02043 480224000373 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 480224000374 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 480224000375 DTAP/Switch II; other site 480224000376 Switch I; other site 480224000377 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 480224000378 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 480224000379 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 480224000380 DTAP/Switch II; other site 480224000381 Switch I; other site 480224000382 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 480224000383 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 480224000384 PGAP1-like protein; Region: PGAP1; pfam07819 480224000385 PGAP1-like protein; Region: PGAP1; pfam07819 480224000386 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 480224000387 O-methyltransferase; Region: Methyltransf_2; pfam00891 480224000388 bacteriochlorophyll/chlorophyll synthetase; Region: chlor_syn_BchG; TIGR01476 480224000389 UbiA prenyltransferase family; Region: UbiA; pfam01040 480224000390 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 480224000391 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 480224000392 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 480224000393 hydrophobic ligand binding site; other site 480224000394 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 480224000395 non-specific DNA binding site [nucleotide binding]; other site 480224000396 salt bridge; other site 480224000397 sequence-specific DNA binding site [nucleotide binding]; other site 480224000398 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 480224000399 Peptidase family M23; Region: Peptidase_M23; pfam01551 480224000400 ABC-2 type transporter; Region: ABC2_membrane; cl17235 480224000401 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 480224000402 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 480224000403 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 480224000404 Walker A/P-loop; other site 480224000405 ATP binding site [chemical binding]; other site 480224000406 Q-loop/lid; other site 480224000407 ABC transporter signature motif; other site 480224000408 Walker B; other site 480224000409 D-loop; other site 480224000410 H-loop/switch region; other site 480224000411 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 480224000412 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 480224000413 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 480224000414 Uncharacterized conserved protein [Function unknown]; Region: COG3595 480224000415 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 480224000416 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 480224000417 active site 480224000418 LabA_like proteins; Region: LabA_like; cd06167 480224000419 putative metal binding site [ion binding]; other site 480224000420 Methyltransferase domain; Region: Methyltransf_31; pfam13847 480224000421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224000422 S-adenosylmethionine binding site [chemical binding]; other site 480224000423 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 480224000424 homooctamer interface [polypeptide binding]; other site 480224000425 active site 480224000426 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 480224000427 RibD C-terminal domain; Region: RibD_C; cl17279 480224000428 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 480224000429 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 480224000430 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 480224000431 putative NAD(P) binding site [chemical binding]; other site 480224000432 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 480224000433 active site 480224000434 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 480224000435 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224000436 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 480224000437 DNA-binding site [nucleotide binding]; DNA binding site 480224000438 RNA-binding motif; other site 480224000439 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 480224000440 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 480224000441 PYR/PP interface [polypeptide binding]; other site 480224000442 dimer interface [polypeptide binding]; other site 480224000443 TPP binding site [chemical binding]; other site 480224000444 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 480224000445 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 480224000446 TPP-binding site [chemical binding]; other site 480224000447 dimer interface [polypeptide binding]; other site 480224000448 ketol-acid reductoisomerase; Provisional; Region: PRK05479 480224000449 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 480224000450 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 480224000451 2-isopropylmalate synthase; Validated; Region: PRK00915 480224000452 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 480224000453 active site 480224000454 catalytic residues [active] 480224000455 metal binding site [ion binding]; metal-binding site 480224000456 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 480224000457 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 480224000458 Prephenate dehydratase; Region: PDT; pfam00800 480224000459 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 480224000460 putative L-Phe binding site [chemical binding]; other site 480224000461 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 480224000462 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 480224000463 substrate binding site [chemical binding]; other site 480224000464 ligand binding site [chemical binding]; other site 480224000465 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 480224000466 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 480224000467 substrate binding site [chemical binding]; other site 480224000468 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 480224000469 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 480224000470 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 480224000471 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 480224000472 Transglycosylase; Region: Transgly; pfam00912 480224000473 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 480224000474 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 480224000475 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 480224000476 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 480224000477 putative active site [active] 480224000478 putative catalytic site [active] 480224000479 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 480224000480 putative active site [active] 480224000481 putative catalytic site [active] 480224000482 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 480224000483 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 480224000484 CoA-transferase family III; Region: CoA_transf_3; pfam02515 480224000485 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 480224000486 CoA-transferase family III; Region: CoA_transf_3; pfam02515 480224000487 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 480224000488 CoA-transferase family III; Region: CoA_transf_3; pfam02515 480224000489 Uncharacterized conserved protein [Function unknown]; Region: COG3777 480224000490 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 480224000491 active site 2 [active] 480224000492 active site 1 [active] 480224000493 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 480224000494 Cysteine-rich domain; Region: CCG; pfam02754 480224000495 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 480224000496 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 480224000497 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 480224000498 putative molybdopterin cofactor binding site [chemical binding]; other site 480224000499 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 480224000500 putative molybdopterin cofactor binding site; other site 480224000501 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224000502 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 480224000503 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 480224000504 intracellular protease, PfpI family; Region: PfpI; TIGR01382 480224000505 proposed catalytic triad [active] 480224000506 conserved cys residue [active] 480224000507 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 480224000508 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 480224000509 metal binding site [ion binding]; metal-binding site 480224000510 active site 480224000511 I-site; other site 480224000512 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 480224000513 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 480224000514 PAS fold; Region: PAS_4; pfam08448 480224000515 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224000516 putative active site [active] 480224000517 heme pocket [chemical binding]; other site 480224000518 GAF domain; Region: GAF_3; pfam13492 480224000519 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 480224000520 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224000521 dimer interface [polypeptide binding]; other site 480224000522 phosphorylation site [posttranslational modification] 480224000523 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224000524 ATP binding site [chemical binding]; other site 480224000525 Mg2+ binding site [ion binding]; other site 480224000526 G-X-G motif; other site 480224000527 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 480224000528 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 480224000529 active site 480224000530 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 480224000531 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 480224000532 ABC-ATPase subunit interface; other site 480224000533 dimer interface [polypeptide binding]; other site 480224000534 putative PBP binding regions; other site 480224000535 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 480224000536 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 480224000537 ABC-ATPase subunit interface; other site 480224000538 dimer interface [polypeptide binding]; other site 480224000539 putative PBP binding regions; other site 480224000540 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 480224000541 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 480224000542 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 480224000543 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 480224000544 intersubunit interface [polypeptide binding]; other site 480224000545 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 480224000546 Coenzyme A binding pocket [chemical binding]; other site 480224000547 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 480224000548 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 480224000549 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 480224000550 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 480224000551 Predicted permeases [General function prediction only]; Region: RarD; COG2962 480224000552 EamA-like transporter family; Region: EamA; cl17759 480224000553 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 480224000554 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 480224000555 phosphate binding site [ion binding]; other site 480224000556 dimer interface [polypeptide binding]; other site 480224000557 substrate binding site [chemical binding]; other site 480224000558 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 480224000559 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 480224000560 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 480224000561 binding surface 480224000562 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 480224000563 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 480224000564 TrkA-N domain; Region: TrkA_N; pfam02254 480224000565 TrkA-C domain; Region: TrkA_C; pfam02080 480224000566 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 480224000567 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 480224000568 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 480224000569 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 480224000570 FeS/SAM binding site; other site 480224000571 HemN C-terminal domain; Region: HemN_C; pfam06969 480224000572 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 480224000573 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 480224000574 FMN binding site [chemical binding]; other site 480224000575 active site 480224000576 catalytic residues [active] 480224000577 substrate binding site [chemical binding]; other site 480224000578 CSLREA domain; Region: CSLREA_Nterm; TIGR04214 480224000579 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 480224000580 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 480224000581 putative acyl-acceptor binding pocket; other site 480224000582 Protein of unknown function (DUF422); Region: DUF422; cl00991 480224000583 Response regulator receiver domain; Region: Response_reg; pfam00072 480224000584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224000585 active site 480224000586 phosphorylation site [posttranslational modification] 480224000587 intermolecular recognition site; other site 480224000588 dimerization interface [polypeptide binding]; other site 480224000589 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 480224000590 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 480224000591 Predicted transcriptional regulator [Transcription]; Region: COG3355 480224000592 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 480224000593 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 480224000594 oligoendopeptidase F; Region: pepF; TIGR00181 480224000595 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 480224000596 active site 480224000597 Zn binding site [ion binding]; other site 480224000598 Ion channel; Region: Ion_trans_2; pfam07885 480224000599 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 480224000600 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 480224000601 Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with rhodanese-like domains found N-terminal of the metallo-beta-lactamase domain; Region: RHOD_Lact_B; cd01523 480224000602 active site residue [active] 480224000603 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 480224000604 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 480224000605 CPxP motif; other site 480224000606 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 480224000607 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 480224000608 active site residue [active] 480224000609 Putative phosphatase (DUF442); Region: DUF442; cl17385 480224000610 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 480224000611 high affinity sulphate transporter 1; Region: sulP; TIGR00815 480224000612 Sulfate transporter family; Region: Sulfate_transp; pfam00916 480224000613 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 480224000614 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 480224000615 active site residue [active] 480224000616 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 480224000617 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 480224000618 DUF35 OB-fold domain; Region: DUF35; pfam01796 480224000619 Yip1 domain; Region: Yip1; cl17815 480224000620 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 480224000621 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 480224000622 active site 480224000623 hypothetical protein; Provisional; Region: PRK04262 480224000624 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 480224000625 dimer interface [polypeptide binding]; other site 480224000626 active site 480224000627 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 480224000628 homodimer interface [polypeptide binding]; other site 480224000629 catalytic residues [active] 480224000630 NAD binding site [chemical binding]; other site 480224000631 substrate binding pocket [chemical binding]; other site 480224000632 flexible flap; other site 480224000633 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224000634 PAS fold; Region: PAS_3; pfam08447 480224000635 putative active site [active] 480224000636 heme pocket [chemical binding]; other site 480224000637 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224000638 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 480224000639 dimer interface [polypeptide binding]; other site 480224000640 phosphorylation site [posttranslational modification] 480224000641 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224000642 ATP binding site [chemical binding]; other site 480224000643 Mg2+ binding site [ion binding]; other site 480224000644 G-X-G motif; other site 480224000645 Response regulator receiver domain; Region: Response_reg; pfam00072 480224000646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224000647 active site 480224000648 phosphorylation site [posttranslational modification] 480224000649 intermolecular recognition site; other site 480224000650 dimerization interface [polypeptide binding]; other site 480224000651 circadian clock protein KaiC; Reviewed; Region: PRK09302 480224000652 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 480224000653 ATP binding site [chemical binding]; other site 480224000654 Walker B motif; other site 480224000655 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 480224000656 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 480224000657 G1 box; other site 480224000658 Walker A motif; other site 480224000659 ATP binding site [chemical binding]; other site 480224000660 GTP/Mg2+ binding site [chemical binding]; other site 480224000661 Walker B motif; other site 480224000662 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 480224000663 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 480224000664 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 480224000665 active site 480224000666 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 480224000667 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 480224000668 nucleotide binding pocket [chemical binding]; other site 480224000669 K-X-D-G motif; other site 480224000670 catalytic site [active] 480224000671 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 480224000672 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 480224000673 Helix-hairpin-helix motif; Region: HHH; pfam00633 480224000674 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 480224000675 Dimer interface [polypeptide binding]; other site 480224000676 BRCT sequence motif; other site 480224000677 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 480224000678 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 480224000679 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 480224000680 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 480224000681 G1 box; other site 480224000682 putative GEF interaction site [polypeptide binding]; other site 480224000683 GTP/Mg2+ binding site [chemical binding]; other site 480224000684 Switch I region; other site 480224000685 G2 box; other site 480224000686 G3 box; other site 480224000687 Switch II region; other site 480224000688 G4 box; other site 480224000689 G5 box; other site 480224000690 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 480224000691 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 480224000692 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 480224000693 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 480224000694 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 480224000695 endonuclease III; Region: ENDO3c; smart00478 480224000696 minor groove reading motif; other site 480224000697 helix-hairpin-helix signature motif; other site 480224000698 substrate binding pocket [chemical binding]; other site 480224000699 active site 480224000700 ribonuclease PH; Reviewed; Region: rph; PRK00173 480224000701 Ribonuclease PH; Region: RNase_PH_bact; cd11362 480224000702 hexamer interface [polypeptide binding]; other site 480224000703 active site 480224000704 TPR repeat; Region: TPR_11; pfam13414 480224000705 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224000706 binding surface 480224000707 TPR motif; other site 480224000708 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224000709 binding surface 480224000710 TPR motif; other site 480224000711 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 480224000712 UV-endonuclease UvdE; Region: UvdE; cl10036 480224000713 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 480224000714 active site 480224000715 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 480224000716 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 480224000717 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 480224000718 dimer interface [polypeptide binding]; other site 480224000719 PYR/PP interface [polypeptide binding]; other site 480224000720 TPP binding site [chemical binding]; other site 480224000721 substrate binding site [chemical binding]; other site 480224000722 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778 480224000723 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 480224000724 TPP-binding site [chemical binding]; other site 480224000725 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 480224000726 MutL protein; Region: MutL; pfam13941 480224000727 Transcription elongation factor [Transcription]; Region: SPT5; COG5164 480224000728 Transcription elongation factor [Transcription]; Region: SPT5; COG5164 480224000729 Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862 480224000730 putative hydrophobic ligand binding site [chemical binding]; other site 480224000731 6-phosphofructokinase; Provisional; Region: PRK03202 480224000732 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 480224000733 active site 480224000734 ADP/pyrophosphate binding site [chemical binding]; other site 480224000735 dimerization interface [polypeptide binding]; other site 480224000736 allosteric effector site; other site 480224000737 fructose-1,6-bisphosphate binding site; other site 480224000738 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 480224000739 EDD domain protein, DegV family; Region: DegV; TIGR00762 480224000740 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 480224000741 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 480224000742 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 480224000743 generic binding surface II; other site 480224000744 ssDNA binding site; other site 480224000745 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 480224000746 ATP binding site [chemical binding]; other site 480224000747 putative Mg++ binding site [ion binding]; other site 480224000748 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 480224000749 nucleotide binding region [chemical binding]; other site 480224000750 ATP-binding site [chemical binding]; other site 480224000751 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 480224000752 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 480224000753 E3 interaction surface; other site 480224000754 lipoyl attachment site [posttranslational modification]; other site 480224000755 e3 binding domain; Region: E3_binding; pfam02817 480224000756 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 480224000757 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 480224000758 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 480224000759 Walker A/P-loop; other site 480224000760 ATP binding site [chemical binding]; other site 480224000761 Q-loop/lid; other site 480224000762 ABC transporter signature motif; other site 480224000763 Walker B; other site 480224000764 D-loop; other site 480224000765 H-loop/switch region; other site 480224000766 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 480224000767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224000768 dimer interface [polypeptide binding]; other site 480224000769 conserved gate region; other site 480224000770 putative PBP binding loops; other site 480224000771 ABC-ATPase subunit interface; other site 480224000772 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 480224000773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224000774 dimer interface [polypeptide binding]; other site 480224000775 conserved gate region; other site 480224000776 putative PBP binding loops; other site 480224000777 ABC-ATPase subunit interface; other site 480224000778 phosphate binding protein; Region: ptsS_2; TIGR02136 480224000779 phosphate binding protein; Region: ptsS_2; TIGR02136 480224000780 Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212 480224000781 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 480224000782 amidase catalytic site [active] 480224000783 Zn binding residues [ion binding]; other site 480224000784 substrate binding site [chemical binding]; other site 480224000785 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 480224000786 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 480224000787 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224000788 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224000789 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224000790 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224000791 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 480224000792 Histidine kinase; Region: HisKA_2; pfam07568 480224000793 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 480224000794 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 480224000795 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 480224000796 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 480224000797 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 480224000798 Walker A/P-loop; other site 480224000799 ATP binding site [chemical binding]; other site 480224000800 Q-loop/lid; other site 480224000801 ABC transporter signature motif; other site 480224000802 Walker B; other site 480224000803 D-loop; other site 480224000804 H-loop/switch region; other site 480224000805 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 480224000806 active site 480224000807 transcription termination factor Rho; Provisional; Region: rho; PRK09376 480224000808 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 480224000809 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 480224000810 RNA binding site [nucleotide binding]; other site 480224000811 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 480224000812 multimer interface [polypeptide binding]; other site 480224000813 Walker A motif; other site 480224000814 ATP binding site [chemical binding]; other site 480224000815 Walker B motif; other site 480224000816 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 480224000817 Double zinc ribbon; Region: DZR; pfam12773 480224000818 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 480224000819 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 480224000820 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 480224000821 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 480224000822 putative chaperone; Provisional; Region: PRK11678 480224000823 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 480224000824 nucleotide binding site [chemical binding]; other site 480224000825 putative NEF/HSP70 interaction site [polypeptide binding]; other site 480224000826 SBD interface [polypeptide binding]; other site 480224000827 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 480224000828 dimer interface [polypeptide binding]; other site 480224000829 active site 480224000830 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 480224000831 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 480224000832 ligand binding site [chemical binding]; other site 480224000833 NAD binding site [chemical binding]; other site 480224000834 dimerization interface [polypeptide binding]; other site 480224000835 catalytic site [active] 480224000836 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 480224000837 putative L-serine binding site [chemical binding]; other site 480224000838 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 480224000839 DNA primase, catalytic core; Region: dnaG; TIGR01391 480224000840 CHC2 zinc finger; Region: zf-CHC2; cl17510 480224000841 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 480224000842 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 480224000843 AAA-like domain; Region: AAA_10; pfam12846 480224000844 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 480224000845 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 480224000846 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 480224000847 catalytic residues [active] 480224000848 catalytic nucleophile [active] 480224000849 Recombinase; Region: Recombinase; pfam07508 480224000850 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 480224000851 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 480224000852 substrate binding site [chemical binding]; other site 480224000853 putative active site [active] 480224000854 redox center [active] 480224000855 Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212 480224000856 CSLREA domain; Region: CSLREA_Nterm; TIGR04214 480224000857 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 480224000858 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 480224000859 CSLREA domain; Region: CSLREA_Nterm; TIGR04214 480224000860 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 480224000861 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 480224000862 Thioredoxin; Region: Thioredoxin_4; pfam13462 480224000863 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 480224000864 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 480224000865 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 480224000866 Walker A motif; other site 480224000867 ATP binding site [chemical binding]; other site 480224000868 Walker B motif; other site 480224000869 arginine finger; other site 480224000870 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 480224000871 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 480224000872 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 480224000873 putative dimer interface [polypeptide binding]; other site 480224000874 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 480224000875 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 480224000876 protein binding site [polypeptide binding]; other site 480224000877 chaperone protein DnaJ; Provisional; Region: PRK14299 480224000878 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 480224000879 HSP70 interaction site [polypeptide binding]; other site 480224000880 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 480224000881 substrate binding site [polypeptide binding]; other site 480224000882 dimer interface [polypeptide binding]; other site 480224000883 Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]; Region: eRF1; COG1503 480224000884 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 480224000885 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 480224000886 Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein). Individual proteins of this band 7 domain family may...; Region: Band_7_prohibitin; cd03401 480224000887 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 480224000888 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 480224000889 putative ligand binding site [chemical binding]; other site 480224000890 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 480224000891 dimer interface [polypeptide binding]; other site 480224000892 [2Fe-2S] cluster binding site [ion binding]; other site 480224000893 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 480224000894 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 480224000895 ABC-ATPase subunit interface; other site 480224000896 dimer interface [polypeptide binding]; other site 480224000897 putative PBP binding regions; other site 480224000898 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 480224000899 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 480224000900 Walker A/P-loop; other site 480224000901 ATP binding site [chemical binding]; other site 480224000902 Q-loop/lid; other site 480224000903 ABC transporter signature motif; other site 480224000904 Walker B; other site 480224000905 D-loop; other site 480224000906 H-loop/switch region; other site 480224000907 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 480224000908 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 480224000909 intersubunit interface [polypeptide binding]; other site 480224000910 flavodoxin FldA; Validated; Region: PRK09267 480224000911 ApaLI-like restriction endonuclease; Region: RE_ApaLI; pfam09499 480224000912 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 480224000913 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224000914 S-adenosylmethionine binding site [chemical binding]; other site 480224000915 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 480224000916 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 480224000917 Walker A/P-loop; other site 480224000918 ATP binding site [chemical binding]; other site 480224000919 Q-loop/lid; other site 480224000920 ABC transporter signature motif; other site 480224000921 Walker B; other site 480224000922 D-loop; other site 480224000923 H-loop/switch region; other site 480224000924 TOBE domain; Region: TOBE_2; pfam08402 480224000925 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 480224000926 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224000927 dimer interface [polypeptide binding]; other site 480224000928 conserved gate region; other site 480224000929 putative PBP binding loops; other site 480224000930 ABC-ATPase subunit interface; other site 480224000931 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224000932 dimer interface [polypeptide binding]; other site 480224000933 conserved gate region; other site 480224000934 putative PBP binding loops; other site 480224000935 ABC-ATPase subunit interface; other site 480224000936 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 480224000937 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 480224000938 YwiC-like protein; Region: YwiC; pfam14256 480224000939 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 480224000940 Saccharomyces cerevisiae homocitrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_HCS; cd07948 480224000941 homocitrate synthase; Region: LysS_fung_arch; TIGR02146 480224000942 active site 480224000943 catalytic residues [active] 480224000944 metal binding site [ion binding]; metal-binding site 480224000945 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 480224000946 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 480224000947 substrate binding site [chemical binding]; other site 480224000948 ligand binding site [chemical binding]; other site 480224000949 homoaconitate hydratase small subunit; Provisional; Region: PRK14023 480224000950 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 480224000951 substrate binding site [chemical binding]; other site 480224000952 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 480224000953 tartrate dehydrogenase; Region: TTC; TIGR02089 480224000954 lysine biosynthesis protein LysW; Region: lysW; TIGR01206 480224000955 lysine biosynthesis protein LysW; Region: lysW; TIGR01206 480224000956 Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144 480224000957 ATP-grasp domain; Region: ATP-grasp_4; cl17255 480224000958 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 480224000959 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 480224000960 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 480224000961 SPFH domain / Band 7 family; Region: Band_7; pfam01145 480224000962 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 480224000963 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 480224000964 Ligand binding site; other site 480224000965 Putative Catalytic site; other site 480224000966 DXD motif; other site 480224000967 ATP-binding cassette domain of MutS homologs; Region: ABC_MutS_homologs; cd03243 480224000968 Walker A/P-loop; other site 480224000969 ATP binding site [chemical binding]; other site 480224000970 Q-loop/lid; other site 480224000971 ABC transporter signature motif; other site 480224000972 Walker B; other site 480224000973 D-loop; other site 480224000974 H-loop/switch region; other site 480224000975 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 480224000976 Walker A/P-loop; other site 480224000977 ATP binding site [chemical binding]; other site 480224000978 Q-loop/lid; other site 480224000979 ABC transporter signature motif; other site 480224000980 Walker B; other site 480224000981 D-loop; other site 480224000982 H-loop/switch region; other site 480224000983 DNA polymerase I; Provisional; Region: PRK05755 480224000984 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 480224000985 active site 480224000986 metal binding site 1 [ion binding]; metal-binding site 480224000987 putative 5' ssDNA interaction site; other site 480224000988 metal binding site 3; metal-binding site 480224000989 metal binding site 2 [ion binding]; metal-binding site 480224000990 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 480224000991 putative DNA binding site [nucleotide binding]; other site 480224000992 putative metal binding site [ion binding]; other site 480224000993 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 480224000994 active site 480224000995 catalytic site [active] 480224000996 substrate binding site [chemical binding]; other site 480224000997 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 480224000998 active site 480224000999 DNA binding site [nucleotide binding] 480224001000 catalytic site [active] 480224001001 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 480224001002 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 480224001003 active site 480224001004 Zn binding site [ion binding]; other site 480224001005 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 480224001006 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 480224001007 putative active site [active] 480224001008 oxyanion strand; other site 480224001009 catalytic triad [active] 480224001010 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 480224001011 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 480224001012 catalytic residues [active] 480224001013 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 480224001014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224001015 S-adenosylmethionine binding site [chemical binding]; other site 480224001016 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 480224001017 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 480224001018 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 480224001019 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 480224001020 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 480224001021 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 480224001022 RDD family; Region: RDD; pfam06271 480224001023 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 480224001024 catalytic core [active] 480224001025 Thymidylate synthase complementing protein; Region: Thy1; cl03630 480224001026 Thymidylate synthase complementing protein; Region: Thy1; pfam02511 480224001027 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 480224001028 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 480224001029 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 480224001030 catalytic loop [active] 480224001031 iron binding site [ion binding]; other site 480224001032 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 480224001033 putative acyl-acceptor binding pocket; other site 480224001034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 480224001035 Major Facilitator Superfamily; Region: MFS_1; pfam07690 480224001036 putative substrate translocation pore; other site 480224001037 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 480224001038 dimerization interface [polypeptide binding]; other site 480224001039 active site 480224001040 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 480224001041 beta-galactosidase; Region: BGL; TIGR03356 480224001042 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 480224001043 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 480224001044 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 480224001045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224001046 dimer interface [polypeptide binding]; other site 480224001047 conserved gate region; other site 480224001048 putative PBP binding loops; other site 480224001049 ABC-ATPase subunit interface; other site 480224001050 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 480224001051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224001052 dimer interface [polypeptide binding]; other site 480224001053 conserved gate region; other site 480224001054 putative PBP binding loops; other site 480224001055 ABC-ATPase subunit interface; other site 480224001056 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 480224001057 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 480224001058 Transcriptional regulators [Transcription]; Region: PurR; COG1609 480224001059 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 480224001060 DNA binding site [nucleotide binding] 480224001061 domain linker motif; other site 480224001062 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 480224001063 dimerization interface [polypeptide binding]; other site 480224001064 ligand binding site [chemical binding]; other site 480224001065 LabA_like proteins; Region: LabA_like; cd06167 480224001066 putative metal binding site [ion binding]; other site 480224001067 Uncharacterized conserved protein [Function unknown]; Region: COG1432 480224001068 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 480224001069 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 480224001070 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 480224001071 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 480224001072 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 480224001073 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 480224001074 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 480224001075 Domain interface; other site 480224001076 Peptide binding site; other site 480224001077 Active site tetrad [active] 480224001078 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 480224001079 NAD(P) binding site [chemical binding]; other site 480224001080 active site 480224001081 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 480224001082 active site 480224001083 catalytic residues [active] 480224001084 metal binding site [ion binding]; metal-binding site 480224001085 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 480224001086 dimer interface [polypeptide binding]; other site 480224001087 substrate binding site [chemical binding]; other site 480224001088 ATP binding site [chemical binding]; other site 480224001089 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 480224001090 thiamine phosphate binding site [chemical binding]; other site 480224001091 active site 480224001092 pyrophosphate binding site [ion binding]; other site 480224001093 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 480224001094 substrate binding site [chemical binding]; other site 480224001095 multimerization interface [polypeptide binding]; other site 480224001096 ATP binding site [chemical binding]; other site 480224001097 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 480224001098 Predicted oxidoreductase [General function prediction only]; Region: COG3573 480224001099 short chain dehydrogenase; Provisional; Region: PRK06181 480224001100 classical (c) SDRs; Region: SDR_c; cd05233 480224001101 NAD(P) binding site [chemical binding]; other site 480224001102 active site 480224001103 Phosphotransferase enzyme family; Region: APH; pfam01636 480224001104 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 480224001105 active site 480224001106 ATP binding site [chemical binding]; other site 480224001107 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 480224001108 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 480224001109 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 480224001110 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 480224001111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 480224001112 Major Facilitator Superfamily; Region: MFS_1; pfam07690 480224001113 putative substrate translocation pore; other site 480224001114 Transcriptional regulators [Transcription]; Region: PurR; COG1609 480224001115 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 480224001116 DNA binding site [nucleotide binding] 480224001117 domain linker motif; other site 480224001118 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 480224001119 putative dimerization interface [polypeptide binding]; other site 480224001120 putative ligand binding site [chemical binding]; other site 480224001121 translation initiation factor IF-3; Region: infC; TIGR00168 480224001122 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 480224001123 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 480224001124 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 480224001125 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 480224001126 23S rRNA binding site [nucleotide binding]; other site 480224001127 L21 binding site [polypeptide binding]; other site 480224001128 L13 binding site [polypeptide binding]; other site 480224001129 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 480224001130 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 480224001131 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 480224001132 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 480224001133 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 480224001134 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 480224001135 dimer interface [polypeptide binding]; other site 480224001136 motif 1; other site 480224001137 active site 480224001138 motif 2; other site 480224001139 motif 3; other site 480224001140 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 480224001141 EamA-like transporter family; Region: EamA; pfam00892 480224001142 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 480224001143 Right handed beta helix region; Region: Beta_helix; pfam13229 480224001144 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 480224001145 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 480224001146 Predicted membrane protein [Function unknown]; Region: COG1470 480224001147 Predicted membrane protein [Function unknown]; Region: COG1470 480224001148 Dehydroquinase class II; Region: DHquinase_II; pfam01220 480224001149 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 480224001150 trimer interface [polypeptide binding]; other site 480224001151 active site 480224001152 dimer interface [polypeptide binding]; other site 480224001153 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 480224001154 Domain of unknown function DUF59; Region: DUF59; cl00941 480224001155 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 480224001156 MPT binding site; other site 480224001157 trimer interface [polypeptide binding]; other site 480224001158 Haemolytic domain; Region: Haemolytic; pfam01809 480224001159 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 480224001160 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 480224001161 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 480224001162 DNA binding residues [nucleotide binding] 480224001163 CHASE domain; Region: CHASE; pfam03924 480224001164 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224001165 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 480224001166 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224001167 dimer interface [polypeptide binding]; other site 480224001168 phosphorylation site [posttranslational modification] 480224001169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224001170 ATP binding site [chemical binding]; other site 480224001171 Mg2+ binding site [ion binding]; other site 480224001172 G-X-G motif; other site 480224001173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224001174 Response regulator receiver domain; Region: Response_reg; pfam00072 480224001175 active site 480224001176 phosphorylation site [posttranslational modification] 480224001177 intermolecular recognition site; other site 480224001178 dimerization interface [polypeptide binding]; other site 480224001179 Response regulator receiver domain; Region: Response_reg; pfam00072 480224001180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224001181 active site 480224001182 phosphorylation site [posttranslational modification] 480224001183 intermolecular recognition site; other site 480224001184 dimerization interface [polypeptide binding]; other site 480224001185 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 480224001186 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 480224001187 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 480224001188 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 480224001189 Ligand binding site; other site 480224001190 Ligand binding site; other site 480224001191 Ligand binding site; other site 480224001192 Putative Catalytic site; other site 480224001193 DXD motif; other site 480224001194 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 480224001195 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 480224001196 Probable Catalytic site; other site 480224001197 metal-binding site 480224001198 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 480224001199 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 480224001200 NADP binding site [chemical binding]; other site 480224001201 active site 480224001202 putative substrate binding site [chemical binding]; other site 480224001203 Response regulator receiver domain; Region: Response_reg; pfam00072 480224001204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224001205 active site 480224001206 phosphorylation site [posttranslational modification] 480224001207 intermolecular recognition site; other site 480224001208 dimerization interface [polypeptide binding]; other site 480224001209 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 480224001210 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 480224001211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224001212 ATP binding site [chemical binding]; other site 480224001213 Mg2+ binding site [ion binding]; other site 480224001214 G-X-G motif; other site 480224001215 Domain of unknown function DUF11; Region: DUF11; cl17728 480224001216 Cna protein B-type domain; Region: Cna_B; pfam05738 480224001217 Cna protein B-type domain; Region: Cna_B; pfam05738 480224001218 Cna protein B-type domain; Region: Cna_B; pfam05738 480224001219 Cna protein B-type domain; Region: Cna_B; pfam05738 480224001220 Cna protein B-type domain; Region: Cna_B; pfam05738 480224001221 Cna protein B-type domain; Region: Cna_B; pfam05738 480224001222 Cna protein B-type domain; Region: Cna_B; pfam05738 480224001223 Cna protein B-type domain; Region: Cna_B; pfam05738 480224001224 Cna protein B-type domain; Region: Cna_B; pfam05738 480224001225 Cna protein B-type domain; Region: Cna_B; pfam05738 480224001226 Cna protein B-type domain; Region: Cna_B; pfam05738 480224001227 Cna protein B-type domain; Region: Cna_B; pfam05738 480224001228 Cna protein B-type domain; Region: Cna_B; pfam05738 480224001229 Cna protein B-type domain; Region: Cna_B; pfam05738 480224001230 Cna protein B-type domain; Region: Cna_B; pfam05738 480224001231 Cna protein B-type domain; Region: Cna_B; pfam05738 480224001232 Cna protein B-type domain; Region: Cna_B; pfam05738 480224001233 Cna protein B-type domain; Region: Cna_B; pfam05738 480224001234 PUCC protein; Region: PUCC; pfam03209 480224001235 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 480224001236 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224001237 S-adenosylmethionine binding site [chemical binding]; other site 480224001238 2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284 480224001239 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202 480224001240 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 480224001241 putative NAD(P) binding site [chemical binding]; other site 480224001242 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 480224001243 chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016 480224001244 Cell division protein FtsQ; Region: FtsQ; pfam03799 480224001245 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 480224001246 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 480224001247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 480224001248 magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031 480224001249 Walker A motif; other site 480224001250 ATP binding site [chemical binding]; other site 480224001251 Walker B motif; other site 480224001252 arginine finger; other site 480224001253 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 480224001254 metal ion-dependent adhesion site (MIDAS); other site 480224001255 recombination factor protein RarA; Reviewed; Region: PRK13342 480224001256 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 480224001257 Walker A motif; other site 480224001258 ATP binding site [chemical binding]; other site 480224001259 Walker B motif; other site 480224001260 arginine finger; other site 480224001261 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 480224001262 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 480224001263 hydroxyglutarate oxidase; Provisional; Region: PRK11728 480224001264 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 480224001265 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 480224001266 Walker A/P-loop; other site 480224001267 ATP binding site [chemical binding]; other site 480224001268 Q-loop/lid; other site 480224001269 ABC transporter signature motif; other site 480224001270 Walker B; other site 480224001271 D-loop; other site 480224001272 H-loop/switch region; other site 480224001273 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 480224001274 NMT1/THI5 like; Region: NMT1; pfam09084 480224001275 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 480224001276 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224001277 dimer interface [polypeptide binding]; other site 480224001278 conserved gate region; other site 480224001279 putative PBP binding loops; other site 480224001280 ABC-ATPase subunit interface; other site 480224001281 Domain of unknown function DUF77; Region: DUF77; pfam01910 480224001282 Methyltransferase domain; Region: Methyltransf_23; pfam13489 480224001283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224001284 S-adenosylmethionine binding site [chemical binding]; other site 480224001285 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 480224001286 Membrane protein of unknown function; Region: DUF360; pfam04020 480224001287 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 480224001288 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 480224001289 active site 480224001290 catalytic site [active] 480224001291 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 480224001292 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 480224001293 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224001294 homodimer interface [polypeptide binding]; other site 480224001295 catalytic residue [active] 480224001296 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 480224001297 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 480224001298 HAS barrel domain; Region: HAS-barrel; pfam09378 480224001299 NurA domain; Region: NurA; pfam09376 480224001300 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 480224001301 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 480224001302 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 480224001303 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 480224001304 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 480224001305 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 480224001306 HflX GTPase family; Region: HflX; cd01878 480224001307 G1 box; other site 480224001308 GTP/Mg2+ binding site [chemical binding]; other site 480224001309 Switch I region; other site 480224001310 G2 box; other site 480224001311 G3 box; other site 480224001312 Switch II region; other site 480224001313 G4 box; other site 480224001314 G5 box; other site 480224001315 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 480224001316 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 480224001317 DnaJ_C chaperone protein; Provisional; Region: PTZ00037 480224001318 seryl-tRNA synthetase; Provisional; Region: PRK05431 480224001319 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 480224001320 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 480224001321 dimer interface [polypeptide binding]; other site 480224001322 active site 480224001323 motif 1; other site 480224001324 motif 2; other site 480224001325 motif 3; other site 480224001326 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 480224001327 putative active site [active] 480224001328 nucleotide binding site [chemical binding]; other site 480224001329 nudix motif; other site 480224001330 putative metal binding site [ion binding]; other site 480224001331 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 480224001332 nudix motif; other site 480224001333 DNA repair protein RadA; Provisional; Region: PRK11823 480224001334 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 480224001335 Walker A motif/ATP binding site; other site 480224001336 ATP binding site [chemical binding]; other site 480224001337 Walker B motif; other site 480224001338 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 480224001339 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 480224001340 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 480224001341 putative active site [active] 480224001342 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 480224001343 putative active site [active] 480224001344 dimerization interface [polypeptide binding]; other site 480224001345 putative tRNAtyr binding site [nucleotide binding]; other site 480224001346 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 480224001347 MgtC family; Region: MgtC; pfam02308 480224001348 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 480224001349 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 480224001350 oligomer interface [polypeptide binding]; other site 480224001351 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 480224001352 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 480224001353 oligomer interface [polypeptide binding]; other site 480224001354 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 480224001355 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 480224001356 oligomer interface [polypeptide binding]; other site 480224001357 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 480224001358 dinuclear metal binding motif [ion binding]; other site 480224001359 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 480224001360 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224001361 ATP binding site [chemical binding]; other site 480224001362 Mg2+ binding site [ion binding]; other site 480224001363 G-X-G motif; other site 480224001364 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 480224001365 GAF domain; Region: GAF_3; pfam13492 480224001366 GAF domain; Region: GAF_2; pfam13185 480224001367 GAF domain; Region: GAF; pfam01590 480224001368 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 480224001369 PAS domain; Region: PAS; smart00091 480224001370 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224001371 dimer interface [polypeptide binding]; other site 480224001372 phosphorylation site [posttranslational modification] 480224001373 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224001374 ATP binding site [chemical binding]; other site 480224001375 Mg2+ binding site [ion binding]; other site 480224001376 G-X-G motif; other site 480224001377 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 480224001378 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 480224001379 catalytic triad [active] 480224001380 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 480224001381 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 480224001382 catalytic triad [active] 480224001383 glutamate racemase; Provisional; Region: PRK00865 480224001384 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 480224001385 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 480224001386 VanW like protein; Region: VanW; pfam04294 480224001387 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224001388 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224001389 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224001390 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224001391 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 480224001392 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224001393 putative active site [active] 480224001394 heme pocket [chemical binding]; other site 480224001395 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224001396 dimer interface [polypeptide binding]; other site 480224001397 phosphorylation site [posttranslational modification] 480224001398 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224001399 ATP binding site [chemical binding]; other site 480224001400 Mg2+ binding site [ion binding]; other site 480224001401 G-X-G motif; other site 480224001402 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 480224001403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224001404 active site 480224001405 phosphorylation site [posttranslational modification] 480224001406 intermolecular recognition site; other site 480224001407 dimerization interface [polypeptide binding]; other site 480224001408 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 480224001409 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 480224001410 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 480224001411 glutaminase active site [active] 480224001412 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 480224001413 dimer interface [polypeptide binding]; other site 480224001414 active site 480224001415 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 480224001416 dimer interface [polypeptide binding]; other site 480224001417 active site 480224001418 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 480224001419 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 480224001420 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 480224001421 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 480224001422 P loop; other site 480224001423 Nucleotide binding site [chemical binding]; other site 480224001424 DTAP/Switch II; other site 480224001425 Switch I; other site 480224001426 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 480224001427 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 480224001428 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 480224001429 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 480224001430 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 480224001431 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 480224001432 Uncharacterized conserved protein [Function unknown]; Region: COG0062 480224001433 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 480224001434 putative substrate binding site [chemical binding]; other site 480224001435 putative ATP binding site [chemical binding]; other site 480224001436 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 480224001437 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 480224001438 LexA repressor; Validated; Region: PRK00215 480224001439 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 480224001440 Catalytic site [active] 480224001441 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 480224001442 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 480224001443 Walker A/P-loop; other site 480224001444 ATP binding site [chemical binding]; other site 480224001445 Q-loop/lid; other site 480224001446 ABC transporter signature motif; other site 480224001447 Walker B; other site 480224001448 D-loop; other site 480224001449 H-loop/switch region; other site 480224001450 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 480224001451 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 480224001452 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 480224001453 Transcriptional regulator [Transcription]; Region: LytR; COG1316 480224001454 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 480224001455 MviN-like protein; Region: MVIN; pfam03023 480224001456 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 480224001457 active site 480224001458 tetramer interface [polypeptide binding]; other site 480224001459 RNase_H superfamily; Region: RNase_H_2; pfam13482 480224001460 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 480224001461 Catalytic domain of Protein Kinases; Region: PKc; cd00180 480224001462 active site 480224001463 ATP binding site [chemical binding]; other site 480224001464 substrate binding site [chemical binding]; other site 480224001465 activation loop (A-loop); other site 480224001466 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 480224001467 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 480224001468 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 480224001469 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 480224001470 Walker A/P-loop; other site 480224001471 ATP binding site [chemical binding]; other site 480224001472 Q-loop/lid; other site 480224001473 ABC transporter signature motif; other site 480224001474 Walker B; other site 480224001475 D-loop; other site 480224001476 H-loop/switch region; other site 480224001477 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 480224001478 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 480224001479 homodimer interface [polypeptide binding]; other site 480224001480 substrate-cofactor binding pocket; other site 480224001481 catalytic residue [active] 480224001482 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 480224001483 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 480224001484 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 480224001485 active site 480224001486 dimerization interface [polypeptide binding]; other site 480224001487 peptide chain release factor 1; Validated; Region: prfA; PRK00591 480224001488 This domain is found in peptide chain release factors; Region: PCRF; smart00937 480224001489 RF-1 domain; Region: RF-1; pfam00472 480224001490 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 480224001491 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 480224001492 active site 480224001493 homodimer interface [polypeptide binding]; other site 480224001494 catalytic site [active] 480224001495 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 480224001496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 480224001497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224001498 dimer interface [polypeptide binding]; other site 480224001499 conserved gate region; other site 480224001500 putative PBP binding loops; other site 480224001501 ABC-ATPase subunit interface; other site 480224001502 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 480224001503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224001504 dimer interface [polypeptide binding]; other site 480224001505 conserved gate region; other site 480224001506 putative PBP binding loops; other site 480224001507 ABC-ATPase subunit interface; other site 480224001508 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 480224001509 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 480224001510 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 480224001511 MarR family; Region: MarR; pfam01047 480224001512 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 480224001513 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 480224001514 Transcriptional regulator [Transcription]; Region: LytR; COG1316 480224001515 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 480224001516 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 480224001517 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 480224001518 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 480224001519 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 480224001520 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 480224001521 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 480224001522 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 480224001523 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 480224001524 active site 480224001525 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 480224001526 AAK_FomA-like: This CD includes a fosfomycin biosynthetic gene product, FomA, and similar proteins found in a wide range of organisms. Together, the fomA and fomB genes in the fosfomycin biosynthetic gene cluster of Streptomyces wedmorensis confer...; Region: AAK_FomA-like; cd04241 480224001527 putative nucleotide binding site [chemical binding]; other site 480224001528 putative substrate binding site [chemical binding]; other site 480224001529 Integral membrane protein DUF95; Region: DUF95; pfam01944 480224001530 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 480224001531 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 480224001532 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 480224001533 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 480224001534 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 480224001535 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 480224001536 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 480224001537 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 480224001538 ATP binding site [chemical binding]; other site 480224001539 Walker A motif; other site 480224001540 hexamer interface [polypeptide binding]; other site 480224001541 Walker B motif; other site 480224001542 Response regulator receiver domain; Region: Response_reg; pfam00072 480224001543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224001544 active site 480224001545 phosphorylation site [posttranslational modification] 480224001546 intermolecular recognition site; other site 480224001547 dimerization interface [polypeptide binding]; other site 480224001548 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 480224001549 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 480224001550 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 480224001551 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 480224001552 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 480224001553 ligand binding site [chemical binding]; other site 480224001554 active site 480224001555 trehalose synthase; Region: treS_nterm; TIGR02456 480224001556 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 480224001557 Ca binding site [ion binding]; other site 480224001558 active site 480224001559 catalytic site [active] 480224001560 Actin-Fragmin Kinase (AFK); catalytic domain. The AFK catalytic domain is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, aminoglycoside...; Region: AFK; cl07713 480224001561 ATP binding site [chemical binding]; other site 480224001562 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 480224001563 recombination protein RecR; Reviewed; Region: recR; PRK00076 480224001564 RecR protein; Region: RecR; pfam02132 480224001565 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 480224001566 putative active site [active] 480224001567 putative metal-binding site [ion binding]; other site 480224001568 tetramer interface [polypeptide binding]; other site 480224001569 hypothetical protein; Provisional; Region: PRK14627 480224001570 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 480224001571 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 480224001572 Walker A motif; other site 480224001573 ATP binding site [chemical binding]; other site 480224001574 Walker B motif; other site 480224001575 arginine finger; other site 480224001576 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 480224001577 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 480224001578 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 480224001579 VPS10 domain; Region: VPS10; smart00602 480224001580 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 480224001581 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224001582 dimer interface [polypeptide binding]; other site 480224001583 phosphorylation site [posttranslational modification] 480224001584 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224001585 ATP binding site [chemical binding]; other site 480224001586 Mg2+ binding site [ion binding]; other site 480224001587 G-X-G motif; other site 480224001588 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 480224001589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224001590 active site 480224001591 phosphorylation site [posttranslational modification] 480224001592 intermolecular recognition site; other site 480224001593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 480224001594 active site 480224001595 phosphorylation site [posttranslational modification] 480224001596 intermolecular recognition site; other site 480224001597 dimerization interface [polypeptide binding]; other site 480224001598 PAS domain; Region: PAS_9; pfam13426 480224001599 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224001600 putative active site [active] 480224001601 heme pocket [chemical binding]; other site 480224001602 GAF domain; Region: GAF_3; pfam13492 480224001603 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 480224001604 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 480224001605 Zn2+ binding site [ion binding]; other site 480224001606 Mg2+ binding site [ion binding]; other site 480224001607 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 480224001608 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 480224001609 SEC-C motif; Region: SEC-C; pfam02810 480224001610 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 480224001611 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 480224001612 Walker A/P-loop; other site 480224001613 ATP binding site [chemical binding]; other site 480224001614 Q-loop/lid; other site 480224001615 ABC transporter signature motif; other site 480224001616 Walker B; other site 480224001617 D-loop; other site 480224001618 H-loop/switch region; other site 480224001619 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 480224001620 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 480224001621 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 480224001622 TM-ABC transporter signature motif; other site 480224001623 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 480224001624 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 480224001625 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 480224001626 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 480224001627 hypothetical protein; Provisional; Region: PRK07233 480224001628 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 480224001629 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 480224001630 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 480224001631 hypothetical protein; Reviewed; Region: PRK09588 480224001632 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 480224001633 putative Zn2+ binding site [ion binding]; other site 480224001634 putative DNA binding site [nucleotide binding]; other site 480224001635 Glycoside hydrolase families 71, 99, and related domains; Region: GH99_GH71_like; cl01529 480224001636 putative catalytic site [active] 480224001637 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 480224001638 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 480224001639 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 480224001640 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 480224001641 Na binding site [ion binding]; other site 480224001642 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 480224001643 Deoxyhypusine synthase; Region: DS; cl00826 480224001644 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 480224001645 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 480224001646 ligand binding site [chemical binding]; other site 480224001647 flexible hinge region; other site 480224001648 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 480224001649 non-specific DNA interactions [nucleotide binding]; other site 480224001650 DNA binding site [nucleotide binding] 480224001651 sequence specific DNA binding site [nucleotide binding]; other site 480224001652 putative cAMP binding site [chemical binding]; other site 480224001653 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 480224001654 Protein of unknown function (DUF3179); Region: DUF3179; pfam11376 480224001655 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 480224001656 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 480224001657 TrkA-C domain; Region: TrkA_C; pfam02080 480224001658 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 480224001659 PhoU domain; Region: PhoU; pfam01895 480224001660 PhoU domain; Region: PhoU; pfam01895 480224001661 Staphylococcal nuclease homologues; Region: SNc; smart00318 480224001662 Catalytic site; other site 480224001663 Staphylococcal nuclease homologue; Region: SNase; pfam00565 480224001664 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 480224001665 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 480224001666 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 480224001667 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 480224001668 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 480224001669 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 480224001670 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437 480224001671 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438 480224001672 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 480224001673 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 480224001674 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 480224001675 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 480224001676 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 480224001677 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 480224001678 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 480224001679 Cu(I) binding site [ion binding]; other site 480224001680 Protein of unknown function (DUF461); Region: DUF461; pfam04314 480224001681 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 480224001682 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 480224001683 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 480224001684 Coenzyme A binding pocket [chemical binding]; other site 480224001685 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 480224001686 CPxP motif; other site 480224001687 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 480224001688 tyrosine phenol-lyase; Provisional; Region: PRK13237 480224001689 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 480224001690 substrate binding site [chemical binding]; other site 480224001691 tetramer interface [polypeptide binding]; other site 480224001692 catalytic residue [active] 480224001693 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 480224001694 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 480224001695 nucleotide binding site [chemical binding]; other site 480224001696 diaminopimelate decarboxylase; Region: lysA; TIGR01048 480224001697 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 480224001698 active site 480224001699 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 480224001700 substrate binding site [chemical binding]; other site 480224001701 catalytic residues [active] 480224001702 dimer interface [polypeptide binding]; other site 480224001703 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 480224001704 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 480224001705 metal-binding site [ion binding] 480224001706 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 480224001707 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 480224001708 metal-binding site [ion binding] 480224001709 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 480224001710 Soluble P-type ATPase [General function prediction only]; Region: COG4087 480224001711 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 480224001712 metal-binding site [ion binding] 480224001713 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 480224001714 putative homodimer interface [polypeptide binding]; other site 480224001715 putative homotetramer interface [polypeptide binding]; other site 480224001716 allosteric switch controlling residues; other site 480224001717 putative metal binding site [ion binding]; other site 480224001718 putative homodimer-homodimer interface [polypeptide binding]; other site 480224001719 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 480224001720 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 480224001721 Walker A/P-loop; other site 480224001722 ATP binding site [chemical binding]; other site 480224001723 Q-loop/lid; other site 480224001724 ABC transporter signature motif; other site 480224001725 Walker B; other site 480224001726 D-loop; other site 480224001727 H-loop/switch region; other site 480224001728 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 480224001729 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 480224001730 NAD(P) binding site [chemical binding]; other site 480224001731 catalytic residues [active] 480224001732 CHAT domain; Region: CHAT; pfam12770 480224001733 AAA ATPase domain; Region: AAA_16; pfam13191 480224001734 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 480224001735 CoA-transferase family III; Region: CoA_transf_3; pfam02515 480224001736 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 480224001737 catalytic residues [active] 480224001738 YtkA-like; Region: YtkA; pfam13115 480224001739 Protein of unknown function (DUF507); Region: DUF507; cl01112 480224001740 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 480224001741 intersubunit interface [polypeptide binding]; other site 480224001742 active site 480224001743 Zn2+ binding site [ion binding]; other site 480224001744 amidase; Provisional; Region: PRK07486 480224001745 Amidase; Region: Amidase; pfam01425 480224001746 Uncharacterized conserved protein [Function unknown]; Region: COG3268 480224001747 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 480224001748 NAD(P) binding site [chemical binding]; other site 480224001749 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 480224001750 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 480224001751 DNA binding site [nucleotide binding] 480224001752 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 480224001753 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 480224001754 DNA binding site [nucleotide binding] 480224001755 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 480224001756 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 480224001757 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 480224001758 active site residue [active] 480224001759 AAA ATPase domain; Region: AAA_16; pfam13191 480224001760 Predicted ATPase [General function prediction only]; Region: COG3903 480224001761 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224001762 TPR motif; other site 480224001763 binding surface 480224001764 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224001765 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 480224001766 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 480224001767 TrkA-C domain; Region: TrkA_C; pfam02080 480224001768 TrkA-C domain; Region: TrkA_C; pfam02080 480224001769 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 480224001770 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 480224001771 Predicted membrane protein [Function unknown]; Region: COG2510 480224001772 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 480224001773 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 480224001774 Walker A/P-loop; other site 480224001775 ATP binding site [chemical binding]; other site 480224001776 Q-loop/lid; other site 480224001777 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 480224001778 ABC transporter signature motif; other site 480224001779 Walker B; other site 480224001780 D-loop; other site 480224001781 H-loop/switch region; other site 480224001782 O-Antigen ligase; Region: Wzy_C; cl04850 480224001783 O-Antigen ligase; Region: Wzy_C; cl04850 480224001784 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224001785 TPR motif; other site 480224001786 binding surface 480224001787 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 480224001788 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 480224001789 Mg++ binding site [ion binding]; other site 480224001790 putative catalytic motif [active] 480224001791 substrate binding site [chemical binding]; other site 480224001792 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 480224001793 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 480224001794 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 480224001795 acyl-activating enzyme (AAE) consensus motif; other site 480224001796 AMP binding site [chemical binding]; other site 480224001797 active site 480224001798 CoA binding site [chemical binding]; other site 480224001799 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 480224001800 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 480224001801 substrate binding site [chemical binding]; other site 480224001802 oxyanion hole (OAH) forming residues; other site 480224001803 trimer interface [polypeptide binding]; other site 480224001804 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 480224001805 NAD(P) binding site [chemical binding]; other site 480224001806 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 480224001807 NAD(P) binding site [chemical binding]; other site 480224001808 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 480224001809 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 480224001810 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 480224001811 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 480224001812 active site 480224001813 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 480224001814 diphosphomevalonate decarboxylase; Region: PLN02407 480224001815 Transposase IS200 like; Region: Y1_Tnp; cl00848 480224001816 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 480224001817 MOFRL family; Region: MOFRL; pfam05161 480224001818 GTP-binding protein YchF; Reviewed; Region: PRK09601 480224001819 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 480224001820 G1 box; other site 480224001821 GTP/Mg2+ binding site [chemical binding]; other site 480224001822 G2 box; other site 480224001823 Switch I region; other site 480224001824 G3 box; other site 480224001825 Switch II region; other site 480224001826 G4 box; other site 480224001827 G5 box; other site 480224001828 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 480224001829 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 480224001830 heme-binding residues [chemical binding]; other site 480224001831 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 480224001832 molybdopterin cofactor binding site; other site 480224001833 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 480224001834 4Fe-4S binding domain; Region: Fer4_2; pfam12797 480224001835 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 480224001836 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 480224001837 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 480224001838 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 480224001839 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 480224001840 Cytochrome c; Region: Cytochrom_C; pfam00034 480224001841 GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441 480224001842 GIY-YIG motif/motif A; other site 480224001843 putative active site [active] 480224001844 putative metal binding site [ion binding]; other site 480224001845 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 480224001846 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 480224001847 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 480224001848 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 480224001849 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 480224001850 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 480224001851 active site 480224001852 substrate binding site [chemical binding]; other site 480224001853 cosubstrate binding site; other site 480224001854 catalytic site [active] 480224001855 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 480224001856 ABC1 family; Region: ABC1; cl17513 480224001857 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 480224001858 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 480224001859 catalytic core [active] 480224001860 Imelysin; Region: Peptidase_M75; pfam09375 480224001861 Iron permease FTR1 family; Region: FTR1; cl00475 480224001862 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 480224001863 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 480224001864 putative FMN binding site [chemical binding]; other site 480224001865 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 480224001866 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 480224001867 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 480224001868 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224001869 Methyltransferase domain; Region: Methyltransf_11; pfam08241 480224001870 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 480224001871 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 480224001872 FeS/SAM binding site; other site 480224001873 HemN C-terminal domain; Region: HemN_C; pfam06969 480224001874 protoporphyrinogen oxidase; Region: PLN02576 480224001875 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 480224001876 NHL repeat; Region: NHL; pfam01436 480224001877 NHL repeat; Region: NHL; pfam01436 480224001878 Clostripain family; Region: Peptidase_C11; pfam03415 480224001879 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 480224001880 putative active site [active] 480224001881 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 480224001882 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 480224001883 PA14 domain; Region: PA14; cl08459 480224001884 Kelch motif; Region: Kelch_5; pfam13854 480224001885 Galactose oxidase, central domain; Region: Kelch_3; cl02701 480224001886 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 480224001887 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 480224001888 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 480224001889 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 480224001890 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 480224001891 active site 480224001892 catalytic triad [active] 480224001893 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 480224001894 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 480224001895 Peptidase family M23; Region: Peptidase_M23; pfam01551 480224001896 PA14 domain; Region: PA14; cl08459 480224001897 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 480224001898 Interdomain contacts; other site 480224001899 Cytokine receptor motif; other site 480224001900 Clostripain family; Region: Peptidase_C11; pfam03415 480224001901 monogalactosyldiacylglycerol synthase; Region: PLN02605 480224001902 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 480224001903 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 480224001904 monogalactosyldiacylglycerol synthase; Region: PLN02605 480224001905 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 480224001906 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 480224001907 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 480224001908 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 480224001909 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 480224001910 Histidine kinase; Region: HisKA_3; pfam07730 480224001911 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224001912 ATP binding site [chemical binding]; other site 480224001913 Mg2+ binding site [ion binding]; other site 480224001914 G-X-G motif; other site 480224001915 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 480224001916 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 480224001917 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224001918 DNA methylase; Region: N6_N4_Mtase; pfam01555 480224001919 Uncharacterized protein conserved in archaea (DUF2115); Region: DUF2115; cl01681 480224001920 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 480224001921 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224001922 active site 480224001923 phosphorylation site [posttranslational modification] 480224001924 intermolecular recognition site; other site 480224001925 dimerization interface [polypeptide binding]; other site 480224001926 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 480224001927 DNA binding residues [nucleotide binding] 480224001928 dimerization interface [polypeptide binding]; other site 480224001929 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 480224001930 Histidine kinase; Region: HisKA_3; pfam07730 480224001931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224001932 ATP binding site [chemical binding]; other site 480224001933 Mg2+ binding site [ion binding]; other site 480224001934 G-X-G motif; other site 480224001935 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 480224001936 Zn binding site [ion binding]; other site 480224001937 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 480224001938 IHF dimer interface [polypeptide binding]; other site 480224001939 IHF - DNA interface [nucleotide binding]; other site 480224001940 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 480224001941 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 480224001942 G1 box; other site 480224001943 GTP/Mg2+ binding site [chemical binding]; other site 480224001944 G2 box; other site 480224001945 Switch I region; other site 480224001946 G3 box; other site 480224001947 Switch II region; other site 480224001948 G4 box; other site 480224001949 G5 box; other site 480224001950 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 480224001951 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 480224001952 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 480224001953 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 480224001954 Ligand Binding Site [chemical binding]; other site 480224001955 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 480224001956 PGAP1-like protein; Region: PGAP1; pfam07819 480224001957 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 480224001958 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 480224001959 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 480224001960 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 480224001961 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 480224001962 acyl-activating enzyme (AAE) consensus motif; other site 480224001963 putative AMP binding site [chemical binding]; other site 480224001964 putative active site [active] 480224001965 putative CoA binding site [chemical binding]; other site 480224001966 SPFH domain / Band 7 family; Region: Band_7; pfam01145 480224001967 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 480224001968 SPFH domain / Band 7 family; Region: Band_7; pfam01145 480224001969 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 480224001970 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 480224001971 non-specific DNA binding site [nucleotide binding]; other site 480224001972 salt bridge; other site 480224001973 sequence-specific DNA binding site [nucleotide binding]; other site 480224001974 PemK-like protein; Region: PemK; pfam02452 480224001975 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 480224001976 FAD binding domain; Region: FAD_binding_4; pfam01565 480224001977 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 480224001978 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 480224001979 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 480224001980 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 480224001981 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 480224001982 PUCC protein; Region: PUCC; pfam03209 480224001983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 480224001984 putative substrate translocation pore; other site 480224001985 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 480224001986 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 480224001987 substrate binding site [chemical binding]; other site 480224001988 active site 480224001989 catalytic residues [active] 480224001990 heterodimer interface [polypeptide binding]; other site 480224001991 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 480224001992 AsnC family; Region: AsnC_trans_reg; pfam01037 480224001993 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 480224001994 sulfite reductase subunit beta; Provisional; Region: PRK13504 480224001995 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 480224001996 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 480224001997 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 480224001998 active site 480224001999 SAM binding site [chemical binding]; other site 480224002000 homodimer interface [polypeptide binding]; other site 480224002001 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 480224002002 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 480224002003 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 480224002004 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 480224002005 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 480224002006 ATP-sulfurylase; Region: ATPS; cd00517 480224002007 active site 480224002008 HXXH motif; other site 480224002009 flexible loop; other site 480224002010 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 480224002011 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 480224002012 Active Sites [active] 480224002013 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 480224002014 ligand-binding site [chemical binding]; other site 480224002015 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224002016 binding surface 480224002017 TPR motif; other site 480224002018 TPR repeat; Region: TPR_11; pfam13414 480224002019 TPR repeat; Region: TPR_11; pfam13414 480224002020 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224002021 binding surface 480224002022 TPR motif; other site 480224002023 Tetratricopeptide repeat; Region: TPR_16; pfam13432 480224002024 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 480224002025 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 480224002026 active site 480224002027 multimer interface [polypeptide binding]; other site 480224002028 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 480224002029 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 480224002030 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 480224002031 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 480224002032 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 480224002033 substrate binding site [chemical binding]; other site 480224002034 ATP binding site [chemical binding]; other site 480224002035 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 480224002036 intersubunit interface [polypeptide binding]; other site 480224002037 active site 480224002038 catalytic residue [active] 480224002039 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 480224002040 CoA binding domain; Region: CoA_binding; smart00881 480224002041 CoA-ligase; Region: Ligase_CoA; pfam00549 480224002042 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224002043 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224002044 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 480224002045 Histidine kinase; Region: HisKA_3; pfam07730 480224002046 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224002047 ATP binding site [chemical binding]; other site 480224002048 Mg2+ binding site [ion binding]; other site 480224002049 G-X-G motif; other site 480224002050 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 480224002051 [2Fe-2S] cluster binding site [ion binding]; other site 480224002052 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 480224002053 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 480224002054 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 480224002055 homodimer interface [polypeptide binding]; other site 480224002056 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 480224002057 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 480224002058 active site 480224002059 homodimer interface [polypeptide binding]; other site 480224002060 catalytic site [active] 480224002061 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 480224002062 Interdomain contacts; other site 480224002063 Cytokine receptor motif; other site 480224002064 Starch binding domain; Region: CBM_2; smart01065 480224002065 starch-binding site 2 [chemical binding]; other site 480224002066 starch-binding site 1 [chemical binding]; other site 480224002067 PspC domain; Region: PspC; pfam04024 480224002068 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 480224002069 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 480224002070 active site 480224002071 metal binding site [ion binding]; metal-binding site 480224002072 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 480224002073 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 480224002074 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 480224002075 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224002076 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 480224002077 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 480224002078 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224002079 TPR motif; other site 480224002080 DNA photolyase; Region: DNA_photolyase; pfam00875 480224002081 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 480224002082 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 480224002083 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 480224002084 active site 480224002085 catalytic triad [active] 480224002086 Uncharacterized conserved protein [Function unknown]; Region: COG1479 480224002087 Protein of unknown function DUF262; Region: DUF262; pfam03235 480224002088 Uncharacterized conserved protein [Function unknown]; Region: COG3472 480224002089 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 480224002090 non-specific DNA binding site [nucleotide binding]; other site 480224002091 salt bridge; other site 480224002092 sequence-specific DNA binding site [nucleotide binding]; other site 480224002093 Predicted ATPase [General function prediction only]; Region: COG3903 480224002094 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 480224002095 active site 480224002096 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 480224002097 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 480224002098 Domain of unknown function DUF87; Region: DUF87; pfam01935 480224002099 HerA helicase [Replication, recombination, and repair]; Region: COG0433 480224002100 NurA domain; Region: NurA; cl09134 480224002101 NurA domain; Region: NurA; pfam09376 480224002102 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 480224002103 Part of AAA domain; Region: AAA_19; pfam13245 480224002104 Family description; Region: UvrD_C_2; pfam13538 480224002105 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 480224002106 active site 480224002107 Response regulator receiver domain; Region: Response_reg; pfam00072 480224002108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224002109 active site 480224002110 phosphorylation site [posttranslational modification] 480224002111 intermolecular recognition site; other site 480224002112 dimerization interface [polypeptide binding]; other site 480224002113 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 480224002114 nucleotide binding site/active site [active] 480224002115 HIT family signature motif; other site 480224002116 catalytic residue [active] 480224002117 peptide chain release factor 2; Provisional; Region: PRK05589 480224002118 This domain is found in peptide chain release factors; Region: PCRF; smart00937 480224002119 RF-1 domain; Region: RF-1; pfam00472 480224002120 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 480224002121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 480224002122 Peptidase family M23; Region: Peptidase_M23; pfam01551 480224002123 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 480224002124 Low molecular weight phosphatase family; Region: LMWPc; cl00105 480224002125 active site 480224002126 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 480224002127 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 480224002128 Chromate transporter; Region: Chromate_transp; pfam02417 480224002129 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 480224002130 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 480224002131 minor groove reading motif; other site 480224002132 helix-hairpin-helix signature motif; other site 480224002133 substrate binding pocket [chemical binding]; other site 480224002134 active site 480224002135 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 480224002136 putative homodimer interface [polypeptide binding]; other site 480224002137 putative active site pocket [active] 480224002138 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 480224002139 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 480224002140 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 480224002141 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224002142 S-adenosylmethionine binding site [chemical binding]; other site 480224002143 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 480224002144 Coenzyme A binding pocket [chemical binding]; other site 480224002145 Sterol carrier protein domain; Region: SCP2_2; pfam13530 480224002146 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 480224002147 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 480224002148 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 480224002149 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 480224002150 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 480224002151 putative active site [active] 480224002152 catalytic triad [active] 480224002153 Protein kinase domain; Region: Pkinase; pfam00069 480224002154 Catalytic domain of Protein Kinases; Region: PKc; cd00180 480224002155 active site 480224002156 ATP binding site [chemical binding]; other site 480224002157 substrate binding site [chemical binding]; other site 480224002158 activation loop (A-loop); other site 480224002159 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 480224002160 Double zinc ribbon; Region: DZR; pfam12773 480224002161 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 480224002162 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 480224002163 phosphopeptide binding site; other site 480224002164 Bacterial SH3 domain; Region: SH3_3; pfam08239 480224002165 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 480224002166 tRNA synthetases class I (C) catalytic domain; Region: tRNA-synt_1e; pfam01406 480224002167 active site 480224002168 HIGH motif; other site 480224002169 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 480224002170 KMSKS motif; other site 480224002171 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 480224002172 cell division protein FtsZ; Validated; Region: PRK09330 480224002173 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 480224002174 nucleotide binding site [chemical binding]; other site 480224002175 SulA interaction site; other site 480224002176 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 480224002177 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 480224002178 nucleotide binding site [chemical binding]; other site 480224002179 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 480224002180 Cell division protein FtsA; Region: FtsA; pfam14450 480224002181 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 480224002182 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 480224002183 Cell division protein FtsQ; Region: FtsQ; pfam03799 480224002184 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 480224002185 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 480224002186 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 480224002187 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14649 480224002188 FAD binding domain; Region: FAD_binding_4; pfam01565 480224002189 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 480224002190 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 480224002191 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 480224002192 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 480224002193 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 480224002194 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 480224002195 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 480224002196 homodimer interface [polypeptide binding]; other site 480224002197 active site 480224002198 cell division protein FtsW; Region: ftsW; TIGR02614 480224002199 Rhomboid family; Region: Rhomboid; pfam01694 480224002200 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 480224002201 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 480224002202 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 480224002203 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 480224002204 Mg++ binding site [ion binding]; other site 480224002205 putative catalytic motif [active] 480224002206 putative substrate binding site [chemical binding]; other site 480224002207 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 480224002208 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 480224002209 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 480224002210 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 480224002211 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 480224002212 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 480224002213 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 480224002214 MraW methylase family; Region: Methyltransf_5; cl17771 480224002215 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 480224002216 cell division protein MraZ; Reviewed; Region: PRK00326 480224002217 MraZ protein; Region: MraZ; pfam02381 480224002218 MraZ protein; Region: MraZ; pfam02381 480224002219 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 480224002220 trimer interface [polypeptide binding]; other site 480224002221 dimer interface [polypeptide binding]; other site 480224002222 putative active site [active] 480224002223 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 480224002224 XdhC Rossmann domain; Region: XdhC_C; pfam13478 480224002225 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 480224002226 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 480224002227 DctM-like transporters; Region: DctM; pfam06808 480224002228 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 480224002229 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 480224002230 Cdc37 C terminal domain; Region: CDC37_C; cl07247 480224002231 YcfA-like protein; Region: YcfA; cl00752 480224002232 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 480224002233 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 480224002234 metal ion-dependent adhesion site (MIDAS); other site 480224002235 EamA-like transporter family; Region: EamA; pfam00892 480224002236 EamA-like transporter family; Region: EamA; pfam00892 480224002237 Bacterial transcriptional activator domain; Region: BTAD; smart01043 480224002238 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 480224002239 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 480224002240 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 480224002241 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 480224002242 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 480224002243 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 480224002244 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 480224002245 minor groove reading motif; other site 480224002246 helix-hairpin-helix signature motif; other site 480224002247 substrate binding pocket [chemical binding]; other site 480224002248 active site 480224002249 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 480224002250 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 480224002251 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 480224002252 CHAT domain; Region: CHAT; pfam12770 480224002253 AAA ATPase domain; Region: AAA_16; pfam13191 480224002254 NACHT domain; Region: NACHT; pfam05729 480224002255 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224002256 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224002257 TPR motif; other site 480224002258 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224002259 binding surface 480224002260 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224002261 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224002262 binding surface 480224002263 TPR motif; other site 480224002264 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224002265 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 480224002266 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 480224002267 peptide binding site [polypeptide binding]; other site 480224002268 dimer interface [polypeptide binding]; other site 480224002269 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 480224002270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224002271 dimer interface [polypeptide binding]; other site 480224002272 conserved gate region; other site 480224002273 putative PBP binding loops; other site 480224002274 ABC-ATPase subunit interface; other site 480224002275 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 480224002276 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 480224002277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224002278 dimer interface [polypeptide binding]; other site 480224002279 conserved gate region; other site 480224002280 putative PBP binding loops; other site 480224002281 ABC-ATPase subunit interface; other site 480224002282 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 480224002283 PLD-like domain; Region: PLDc_2; pfam13091 480224002284 putative active site [active] 480224002285 catalytic site [active] 480224002286 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 480224002287 PLD-like domain; Region: PLDc_2; pfam13091 480224002288 putative active site [active] 480224002289 catalytic site [active] 480224002290 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 480224002291 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 480224002292 peptide binding site [polypeptide binding]; other site 480224002293 dimer interface [polypeptide binding]; other site 480224002294 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 480224002295 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 480224002296 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 480224002297 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 480224002298 Walker A/P-loop; other site 480224002299 ATP binding site [chemical binding]; other site 480224002300 Q-loop/lid; other site 480224002301 ABC transporter signature motif; other site 480224002302 Walker B; other site 480224002303 D-loop; other site 480224002304 H-loop/switch region; other site 480224002305 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 480224002306 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 480224002307 Walker A/P-loop; other site 480224002308 ATP binding site [chemical binding]; other site 480224002309 Q-loop/lid; other site 480224002310 ABC transporter signature motif; other site 480224002311 Walker B; other site 480224002312 D-loop; other site 480224002313 H-loop/switch region; other site 480224002314 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 480224002315 Na binding site [ion binding]; other site 480224002316 Protoglobin; Region: Protoglobin; pfam11563 480224002317 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 480224002318 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 480224002319 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 480224002320 dimerization interface [polypeptide binding]; other site 480224002321 Putative transcription activator [Transcription]; Region: TenA; COG0819 480224002322 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 480224002323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 480224002324 Walker A motif; other site 480224002325 ATP binding site [chemical binding]; other site 480224002326 Walker B motif; other site 480224002327 arginine finger; other site 480224002328 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 480224002329 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 480224002330 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 480224002331 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 480224002332 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 480224002333 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 480224002334 active site 480224002335 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 480224002336 active site 480224002337 phosphorylation site [posttranslational modification] 480224002338 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 480224002339 dimerization domain swap beta strand [polypeptide binding]; other site 480224002340 regulatory protein interface [polypeptide binding]; other site 480224002341 active site 480224002342 regulatory phosphorylation site [posttranslational modification]; other site 480224002343 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 480224002344 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 480224002345 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 480224002346 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 480224002347 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 480224002348 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 480224002349 putative substrate binding site [chemical binding]; other site 480224002350 putative ATP binding site [chemical binding]; other site 480224002351 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 480224002352 active site 480224002353 P-loop; other site 480224002354 phosphorylation site [posttranslational modification] 480224002355 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 480224002356 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 480224002357 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 480224002358 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224002359 putative active site [active] 480224002360 heme pocket [chemical binding]; other site 480224002361 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224002362 dimer interface [polypeptide binding]; other site 480224002363 phosphorylation site [posttranslational modification] 480224002364 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224002365 ATP binding site [chemical binding]; other site 480224002366 Mg2+ binding site [ion binding]; other site 480224002367 G-X-G motif; other site 480224002368 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 480224002369 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 480224002370 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 480224002371 dimer interface [polypeptide binding]; other site 480224002372 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 480224002373 active site 480224002374 Fe binding site [ion binding]; other site 480224002375 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 480224002376 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 480224002377 active site 480224002378 catalytic site [active] 480224002379 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 480224002380 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 480224002381 Cu(I) binding site [ion binding]; other site 480224002382 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 480224002383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224002384 dimer interface [polypeptide binding]; other site 480224002385 conserved gate region; other site 480224002386 putative PBP binding loops; other site 480224002387 ABC-ATPase subunit interface; other site 480224002388 NMT1/THI5 like; Region: NMT1; pfam09084 480224002389 Predicted ATPase [General function prediction only]; Region: COG4637 480224002390 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 480224002391 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 480224002392 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 480224002393 HlyD family secretion protein; Region: HlyD_3; pfam13437 480224002394 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 480224002395 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 480224002396 Walker A/P-loop; other site 480224002397 ATP binding site [chemical binding]; other site 480224002398 Q-loop/lid; other site 480224002399 ABC transporter signature motif; other site 480224002400 Walker B; other site 480224002401 D-loop; other site 480224002402 H-loop/switch region; other site 480224002403 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 480224002404 AAA domain; Region: AAA_30; pfam13604 480224002405 Family description; Region: UvrD_C_2; pfam13538 480224002406 glyoxylate reductase; Reviewed; Region: PRK13243 480224002407 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 480224002408 dimerization interface [polypeptide binding]; other site 480224002409 ligand binding site [chemical binding]; other site 480224002410 NADP binding site [chemical binding]; other site 480224002411 catalytic site [active] 480224002412 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 480224002413 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 480224002414 Coenzyme A binding pocket [chemical binding]; other site 480224002415 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 480224002416 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 480224002417 4Fe-4S binding domain; Region: Fer4; pfam00037 480224002418 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 480224002419 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 480224002420 Cysteine-rich domain; Region: CCG; pfam02754 480224002421 Cysteine-rich domain; Region: CCG; pfam02754 480224002422 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 480224002423 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 480224002424 G1 box; other site 480224002425 putative GEF interaction site [polypeptide binding]; other site 480224002426 GTP/Mg2+ binding site [chemical binding]; other site 480224002427 Switch I region; other site 480224002428 G2 box; other site 480224002429 G3 box; other site 480224002430 Switch II region; other site 480224002431 G4 box; other site 480224002432 G5 box; other site 480224002433 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 480224002434 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 480224002435 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 480224002436 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 480224002437 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 480224002438 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 480224002439 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 480224002440 DNA binding residues [nucleotide binding] 480224002441 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224002442 S-adenosylmethionine binding site [chemical binding]; other site 480224002443 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224002444 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 480224002445 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 480224002446 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 480224002447 CoenzymeA binding site [chemical binding]; other site 480224002448 subunit interaction site [polypeptide binding]; other site 480224002449 PHB binding site; other site 480224002450 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 480224002451 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 480224002452 active site 480224002453 FMN binding site [chemical binding]; other site 480224002454 substrate binding site [chemical binding]; other site 480224002455 homotetramer interface [polypeptide binding]; other site 480224002456 catalytic residue [active] 480224002457 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 480224002458 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 480224002459 ATP binding site [chemical binding]; other site 480224002460 putative Mg++ binding site [ion binding]; other site 480224002461 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 480224002462 nucleotide binding region [chemical binding]; other site 480224002463 ATP-binding site [chemical binding]; other site 480224002464 Methyltransferase domain; Region: Methyltransf_26; pfam13659 480224002465 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 480224002466 UbiA prenyltransferase family; Region: UbiA; pfam01040 480224002467 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; COG0382 480224002468 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 480224002469 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 480224002470 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 480224002471 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 480224002472 Cytochrome c; Region: Cytochrom_C; pfam00034 480224002473 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 480224002474 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 480224002475 catalytic loop [active] 480224002476 iron binding site [ion binding]; other site 480224002477 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 480224002478 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 480224002479 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224002480 S-adenosylmethionine binding site [chemical binding]; other site 480224002481 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224002482 binding surface 480224002483 TPR motif; other site 480224002484 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 480224002485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224002486 active site 480224002487 phosphorylation site [posttranslational modification] 480224002488 intermolecular recognition site; other site 480224002489 CheB methylesterase; Region: CheB_methylest; pfam01339 480224002490 CheW-like domain; Region: CheW; pfam01584 480224002491 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 480224002492 putative binding surface; other site 480224002493 active site 480224002494 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 480224002495 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 480224002496 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224002497 ATP binding site [chemical binding]; other site 480224002498 Mg2+ binding site [ion binding]; other site 480224002499 G-X-G motif; other site 480224002500 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 480224002501 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 480224002502 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224002503 active site 480224002504 phosphorylation site [posttranslational modification] 480224002505 intermolecular recognition site; other site 480224002506 dimerization interface [polypeptide binding]; other site 480224002507 CHASE3 domain; Region: CHASE3; cl05000 480224002508 HAMP domain; Region: HAMP; pfam00672 480224002509 dimerization interface [polypeptide binding]; other site 480224002510 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 480224002511 dimer interface [polypeptide binding]; other site 480224002512 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 480224002513 putative CheW interface [polypeptide binding]; other site 480224002514 Response regulator receiver domain; Region: Response_reg; pfam00072 480224002515 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224002516 active site 480224002517 phosphorylation site [posttranslational modification] 480224002518 intermolecular recognition site; other site 480224002519 dimerization interface [polypeptide binding]; other site 480224002520 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 480224002521 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 480224002522 dimerization interface [polypeptide binding]; other site 480224002523 putative ATP binding site [chemical binding]; other site 480224002524 PAS domain S-box; Region: sensory_box; TIGR00229 480224002525 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224002526 putative active site [active] 480224002527 heme pocket [chemical binding]; other site 480224002528 PAS fold; Region: PAS_4; pfam08448 480224002529 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224002530 putative active site [active] 480224002531 heme pocket [chemical binding]; other site 480224002532 PAS domain S-box; Region: sensory_box; TIGR00229 480224002533 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224002534 putative active site [active] 480224002535 heme pocket [chemical binding]; other site 480224002536 PAS fold; Region: PAS_4; pfam08448 480224002537 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 480224002538 FOG: CBS domain [General function prediction only]; Region: COG0517 480224002539 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 480224002540 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 480224002541 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 480224002542 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 480224002543 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 480224002544 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 480224002545 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 480224002546 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 480224002547 active site 480224002548 octamer interface [polypeptide binding]; other site 480224002549 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 480224002550 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 480224002551 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224002552 S-adenosylmethionine binding site [chemical binding]; other site 480224002553 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 480224002554 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 480224002555 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 480224002556 catalytic site [active] 480224002557 subunit interface [polypeptide binding]; other site 480224002558 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224002559 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 480224002560 putative ADP-binding pocket [chemical binding]; other site 480224002561 hypothetical protein; Provisional; Region: PRK06446 480224002562 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 480224002563 metal binding site [ion binding]; metal-binding site 480224002564 dimer interface [polypeptide binding]; other site 480224002565 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 480224002566 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 480224002567 metal-binding site [ion binding] 480224002568 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 480224002569 Soluble P-type ATPase [General function prediction only]; Region: COG4087 480224002570 6-phosphofructokinase, eukaryotic type; Region: 6PF1K_euk; TIGR02478 480224002571 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 480224002572 active site 480224002573 ADP/pyrophosphate binding site [chemical binding]; other site 480224002574 dimerization interface [polypeptide binding]; other site 480224002575 allosteric effector site; other site 480224002576 fructose-1,6-bisphosphate binding site; other site 480224002577 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 480224002578 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 480224002579 dimer interface [polypeptide binding]; other site 480224002580 ssDNA binding site [nucleotide binding]; other site 480224002581 tetramer (dimer of dimers) interface [polypeptide binding]; other site 480224002582 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 480224002583 AsnC family; Region: AsnC_trans_reg; pfam01037 480224002584 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 480224002585 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 480224002586 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 480224002587 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 480224002588 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 480224002589 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 480224002590 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 480224002591 G-loop; other site 480224002592 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 480224002593 DNA binding site [nucleotide binding] 480224002594 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 480224002595 DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085 480224002596 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 480224002597 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 480224002598 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 480224002599 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 480224002600 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 480224002601 RPB1 interaction site [polypeptide binding]; other site 480224002602 RPB10 interaction site [polypeptide binding]; other site 480224002603 RPB11 interaction site [polypeptide binding]; other site 480224002604 RPB3 interaction site [polypeptide binding]; other site 480224002605 RPB12 interaction site [polypeptide binding]; other site 480224002606 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 480224002607 dimerization interface [polypeptide binding]; other site 480224002608 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224002609 dimer interface [polypeptide binding]; other site 480224002610 phosphorylation site [posttranslational modification] 480224002611 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224002612 ATP binding site [chemical binding]; other site 480224002613 Mg2+ binding site [ion binding]; other site 480224002614 G-X-G motif; other site 480224002615 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 480224002616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224002617 active site 480224002618 phosphorylation site [posttranslational modification] 480224002619 intermolecular recognition site; other site 480224002620 dimerization interface [polypeptide binding]; other site 480224002621 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 480224002622 DNA binding site [nucleotide binding] 480224002623 hypothetical protein; Provisional; Region: PRK06148 480224002624 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 480224002625 active site 480224002626 ATP binding site [chemical binding]; other site 480224002627 Peptidase family M23; Region: Peptidase_M23; pfam01551 480224002628 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 480224002629 inhibitor-cofactor binding pocket; inhibition site 480224002630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224002631 catalytic residue [active] 480224002632 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 480224002633 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 480224002634 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 480224002635 Ca binding site [ion binding]; other site 480224002636 active site 480224002637 catalytic site [active] 480224002638 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 480224002639 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 480224002640 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 480224002641 active site 480224002642 Ca binding site [ion binding]; other site 480224002643 catalytic site [active] 480224002644 Aamy_C domain; Region: Aamy_C; smart00632 480224002645 mevalonate kinase; Region: mevalon_kin; TIGR00549 480224002646 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 480224002647 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320 480224002648 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 480224002649 putative tRNA-binding site [nucleotide binding]; other site 480224002650 B3/4 domain; Region: B3_4; pfam03483 480224002651 tRNA synthetase B5 domain; Region: B5; smart00874 480224002652 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 480224002653 dimer interface [polypeptide binding]; other site 480224002654 motif 1; other site 480224002655 motif 3; other site 480224002656 motif 2; other site 480224002657 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 480224002658 cell division protein MraZ; Reviewed; Region: PRK00326 480224002659 MraZ protein; Region: MraZ; pfam02381 480224002660 MraZ protein; Region: MraZ; pfam02381 480224002661 CHAT domain; Region: CHAT; pfam12770 480224002662 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 480224002663 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 480224002664 amidase catalytic site [active] 480224002665 Zn binding residues [ion binding]; other site 480224002666 substrate binding site [chemical binding]; other site 480224002667 N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510 480224002668 cell division protein FtsZ; Region: ftsZ; TIGR00065 480224002669 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 480224002670 nucleotide binding site [chemical binding]; other site 480224002671 SulA interaction site; other site 480224002672 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 480224002673 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 480224002674 DXD motif; other site 480224002675 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 480224002676 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 480224002677 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224002678 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224002679 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 480224002680 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 480224002681 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 480224002682 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 480224002683 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 480224002684 dimerization interface [polypeptide binding]; other site 480224002685 active site 480224002686 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 480224002687 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 480224002688 Uncharacterized conserved protein [Function unknown]; Region: COG1262 480224002689 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 480224002690 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 480224002691 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 480224002692 GAF domain; Region: GAF_3; pfam13492 480224002693 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 480224002694 Histidine kinase; Region: HisKA_3; pfam07730 480224002695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224002696 ATP binding site [chemical binding]; other site 480224002697 Mg2+ binding site [ion binding]; other site 480224002698 G-X-G motif; other site 480224002699 malate dehydrogenase, NAD-dependent; Region: MalateDH_bact; TIGR01763 480224002700 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 480224002701 NAD(P) binding site [chemical binding]; other site 480224002702 dimer interface [polypeptide binding]; other site 480224002703 tetramer (dimer of dimers) interface [polypeptide binding]; other site 480224002704 substrate binding site [chemical binding]; other site 480224002705 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 480224002706 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 480224002707 RNA binding surface [nucleotide binding]; other site 480224002708 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 480224002709 active site 480224002710 lipoprotein signal peptidase; Provisional; Region: PRK14789 480224002711 lipoprotein signal peptidase; Provisional; Region: PRK14787 480224002712 lipoprotein signal peptidase; Provisional; Region: PRK14790 480224002713 lipoprotein signal peptidase; Provisional; Region: PRK14787 480224002714 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 480224002715 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 480224002716 Walker A motif; other site 480224002717 ATP binding site [chemical binding]; other site 480224002718 Walker B motif; other site 480224002719 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 480224002720 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 480224002721 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 480224002722 Walker A motif; other site 480224002723 ATP binding site [chemical binding]; other site 480224002724 Walker B motif; other site 480224002725 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 480224002726 TadE-like protein; Region: TadE; pfam07811 480224002727 Cna protein B-type domain; Region: Cna_B; pfam05738 480224002728 Domain of unknown function DUF11; Region: DUF11; cl17728 480224002729 Domain of unknown function DUF11; Region: DUF11; pfam01345 480224002730 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 480224002731 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 480224002732 active site 480224002733 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [Transcription]; Region: RpoD; COG0568 480224002734 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 480224002735 phosphopeptide binding site; other site 480224002736 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 480224002737 Methyltransferase domain; Region: Methyltransf_31; pfam13847 480224002738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224002739 S-adenosylmethionine binding site [chemical binding]; other site 480224002740 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224002741 S-adenosylmethionine binding site [chemical binding]; other site 480224002742 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 480224002743 FOG: CBS domain [General function prediction only]; Region: COG0517 480224002744 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 480224002745 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 480224002746 RibD C-terminal domain; Region: RibD_C; cl17279 480224002747 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 480224002748 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 480224002749 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 480224002750 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 480224002751 DNA binding residues [nucleotide binding] 480224002752 Putative zinc-finger; Region: zf-HC2; pfam13490 480224002753 UGMP family protein; Validated; Region: PRK09604 480224002754 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 480224002755 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 480224002756 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 480224002757 catalytic residue [active] 480224002758 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 480224002759 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 480224002760 dimerization interface [polypeptide binding]; other site 480224002761 ligand binding site [chemical binding]; other site 480224002762 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 480224002763 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 480224002764 dimerization interface [polypeptide binding]; other site 480224002765 ligand binding site [chemical binding]; other site 480224002766 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 480224002767 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 480224002768 TM-ABC transporter signature motif; other site 480224002769 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 480224002770 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 480224002771 TM-ABC transporter signature motif; other site 480224002772 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 480224002773 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 480224002774 Walker A/P-loop; other site 480224002775 ATP binding site [chemical binding]; other site 480224002776 Q-loop/lid; other site 480224002777 ABC transporter signature motif; other site 480224002778 Walker B; other site 480224002779 D-loop; other site 480224002780 H-loop/switch region; other site 480224002781 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 480224002782 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 480224002783 Walker A/P-loop; other site 480224002784 ATP binding site [chemical binding]; other site 480224002785 Q-loop/lid; other site 480224002786 ABC transporter signature motif; other site 480224002787 Walker B; other site 480224002788 D-loop; other site 480224002789 H-loop/switch region; other site 480224002790 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 480224002791 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224002792 active site 480224002793 phosphorylation site [posttranslational modification] 480224002794 intermolecular recognition site; other site 480224002795 dimerization interface [polypeptide binding]; other site 480224002796 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 480224002797 DNA binding site [nucleotide binding] 480224002798 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 480224002799 DnaJ domain; Region: DnaJ; pfam00226 480224002800 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 480224002801 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 480224002802 catalytic residues [active] 480224002803 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 480224002804 HSP70 interaction site [polypeptide binding]; other site 480224002805 TPR repeat; Region: TPR_11; pfam13414 480224002806 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224002807 binding surface 480224002808 TPR motif; other site 480224002809 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 480224002810 CcmE; Region: CcmE; cl00994 480224002811 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 480224002812 CcmB protein; Region: CcmB; cl17444 480224002813 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 480224002814 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 480224002815 Walker A/P-loop; other site 480224002816 ATP binding site [chemical binding]; other site 480224002817 Q-loop/lid; other site 480224002818 ABC transporter signature motif; other site 480224002819 Walker B; other site 480224002820 D-loop; other site 480224002821 H-loop/switch region; other site 480224002822 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 480224002823 active site 480224002824 oxyanion hole [active] 480224002825 catalytic triad [active] 480224002826 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 480224002827 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 480224002828 NAD(P) binding site [chemical binding]; other site 480224002829 homodimer interface [polypeptide binding]; other site 480224002830 substrate binding site [chemical binding]; other site 480224002831 active site 480224002832 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 480224002833 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 480224002834 inhibitor-cofactor binding pocket; inhibition site 480224002835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224002836 catalytic residue [active] 480224002837 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 480224002838 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 480224002839 putative trimer interface [polypeptide binding]; other site 480224002840 putative CoA binding site [chemical binding]; other site 480224002841 Bacterial sugar transferase; Region: Bac_transf; pfam02397 480224002842 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 480224002843 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 480224002844 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 480224002845 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 480224002846 replicative DNA helicase; Region: DnaB; TIGR00665 480224002847 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 480224002848 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 480224002849 Walker A motif; other site 480224002850 ATP binding site [chemical binding]; other site 480224002851 Walker B motif; other site 480224002852 DNA binding loops [nucleotide binding] 480224002853 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 480224002854 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 480224002855 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 480224002856 dimer interface [polypeptide binding]; other site 480224002857 PYR/PP interface [polypeptide binding]; other site 480224002858 TPP binding site [chemical binding]; other site 480224002859 substrate binding site [chemical binding]; other site 480224002860 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 480224002861 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 480224002862 TPP-binding site [chemical binding]; other site 480224002863 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 480224002864 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 480224002865 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 480224002866 NAD(P) binding site [chemical binding]; other site 480224002867 catalytic residues [active] 480224002868 Fe-S metabolism associated domain; Region: SufE; cl00951 480224002869 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 480224002870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224002871 active site 480224002872 phosphorylation site [posttranslational modification] 480224002873 intermolecular recognition site; other site 480224002874 dimerization interface [polypeptide binding]; other site 480224002875 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 480224002876 DNA binding site [nucleotide binding] 480224002877 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224002878 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224002879 dimer interface [polypeptide binding]; other site 480224002880 phosphorylation site [posttranslational modification] 480224002881 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224002882 ATP binding site [chemical binding]; other site 480224002883 Mg2+ binding site [ion binding]; other site 480224002884 G-X-G motif; other site 480224002885 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 480224002886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224002887 active site 480224002888 phosphorylation site [posttranslational modification] 480224002889 intermolecular recognition site; other site 480224002890 dimerization interface [polypeptide binding]; other site 480224002891 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 480224002892 Dynamin family; Region: Dynamin_N; pfam00350 480224002893 G1 box; other site 480224002894 GTP/Mg2+ binding site [chemical binding]; other site 480224002895 G2 box; other site 480224002896 Switch I region; other site 480224002897 G3 box; other site 480224002898 Switch II region; other site 480224002899 G4 box; other site 480224002900 G5 box; other site 480224002901 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224002902 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 480224002903 Colicin V production protein; Region: Colicin_V; pfam02674 480224002904 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 480224002905 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 480224002906 hypothetical protein; Provisional; Region: PRK05325 480224002907 SpoVR like protein; Region: SpoVR; pfam04293 480224002908 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 480224002909 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 480224002910 protein-splicing catalytic site; other site 480224002911 thioester formation/cholesterol transfer; other site 480224002912 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 480224002913 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 480224002914 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 480224002915 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 480224002916 Walker A/P-loop; other site 480224002917 ATP binding site [chemical binding]; other site 480224002918 Q-loop/lid; other site 480224002919 ABC transporter signature motif; other site 480224002920 Walker B; other site 480224002921 D-loop; other site 480224002922 H-loop/switch region; other site 480224002923 Bacterial PH domain; Region: DUF304; cl01348 480224002924 cytidylate kinase; Provisional; Region: cmk; PRK00023 480224002925 AAA domain; Region: AAA_17; pfam13207 480224002926 Cytidylate kinase; Region: Cytidylate_kin; pfam02224 480224002927 GMP synthase; Reviewed; Region: guaA; PRK00074 480224002928 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 480224002929 AMP/PPi binding site [chemical binding]; other site 480224002930 candidate oxyanion hole; other site 480224002931 catalytic triad [active] 480224002932 potential glutamine specificity residues [chemical binding]; other site 480224002933 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 480224002934 ATP Binding subdomain [chemical binding]; other site 480224002935 Ligand Binding sites [chemical binding]; other site 480224002936 Dimerization subdomain; other site 480224002937 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 480224002938 active sites [active] 480224002939 tetramer interface [polypeptide binding]; other site 480224002940 imidazolonepropionase; Validated; Region: PRK09356 480224002941 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 480224002942 active site 480224002943 urocanate hydratase; Provisional; Region: PRK05414 480224002944 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 480224002945 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 480224002946 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 480224002947 Soluble P-type ATPase [General function prediction only]; Region: COG4087 480224002948 multicopper oxidase; Provisional; Region: PRK10965 480224002949 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 480224002950 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 480224002951 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 480224002952 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 480224002953 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 480224002954 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 480224002955 N-acetyl-D-glucosamine binding site [chemical binding]; other site 480224002956 catalytic residue [active] 480224002957 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 480224002958 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224002959 MoxR-like ATPases [General function prediction only]; Region: COG0714 480224002960 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 480224002961 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 480224002962 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 480224002963 Probable Catalytic site; other site 480224002964 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224002965 S-adenosylmethionine binding site [chemical binding]; other site 480224002966 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 480224002967 Fe-S cluster binding site [ion binding]; other site 480224002968 active site 480224002969 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 480224002970 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 480224002971 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 480224002972 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 480224002973 trimer interface [polypeptide binding]; other site 480224002974 active site 480224002975 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 480224002976 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224002977 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 480224002978 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 480224002979 active site 480224002980 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 480224002981 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 480224002982 catalytic residue [active] 480224002983 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 480224002984 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 480224002985 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 480224002986 Bacterial SH3 domain; Region: SH3_3; pfam08239 480224002987 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 480224002988 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 480224002989 FtsX-like permease family; Region: FtsX; pfam02687 480224002990 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 480224002991 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 480224002992 Walker A/P-loop; other site 480224002993 ATP binding site [chemical binding]; other site 480224002994 Q-loop/lid; other site 480224002995 ABC transporter signature motif; other site 480224002996 Walker B; other site 480224002997 D-loop; other site 480224002998 H-loop/switch region; other site 480224002999 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 480224003000 HlyD family secretion protein; Region: HlyD_3; pfam13437 480224003001 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 480224003002 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 480224003003 Probable zinc-binding domain; Region: zf-trcl; pfam13451 480224003004 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 480224003005 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 480224003006 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 480224003007 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 480224003008 active site 480224003009 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 480224003010 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 480224003011 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 480224003012 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 480224003013 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 480224003014 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 480224003015 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 480224003016 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 480224003017 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 480224003018 hypothetical protein; Provisional; Region: PRK06446 480224003019 metal binding site [ion binding]; metal-binding site 480224003020 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 480224003021 anti sigma factor interaction site; other site 480224003022 regulatory phosphorylation site [posttranslational modification]; other site 480224003023 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 480224003024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 480224003025 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 480224003026 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 480224003027 ligand binding site [chemical binding]; other site 480224003028 flexible hinge region; other site 480224003029 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 480224003030 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 480224003031 HEAT repeats; Region: HEAT_2; pfam13646 480224003032 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 480224003033 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 480224003034 active site 480224003035 PHP Thumb interface [polypeptide binding]; other site 480224003036 metal binding site [ion binding]; metal-binding site 480224003037 Head binding; Region: Head_binding; pfam09008 480224003038 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 480224003039 generic binding surface II; other site 480224003040 generic binding surface I; other site 480224003041 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 480224003042 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 480224003043 putative [4Fe-4S] binding site [ion binding]; other site 480224003044 putative molybdopterin cofactor binding site [chemical binding]; other site 480224003045 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 480224003046 putative molybdopterin cofactor binding site; other site 480224003047 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 480224003048 Protein of unknown function (DUF2012); Region: DUF2012; pfam09430 480224003049 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 480224003050 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 480224003051 Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635 480224003052 seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474 480224003053 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 480224003054 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 480224003055 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 480224003056 catalytic residue [active] 480224003057 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 480224003058 Ligand binding site; other site 480224003059 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 480224003060 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 480224003061 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 480224003062 dimer interface [polypeptide binding]; other site 480224003063 ssDNA binding site [nucleotide binding]; other site 480224003064 tetramer (dimer of dimers) interface [polypeptide binding]; other site 480224003065 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 480224003066 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 480224003067 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 480224003068 peptide binding site [polypeptide binding]; other site 480224003069 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 480224003070 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224003071 dimer interface [polypeptide binding]; other site 480224003072 conserved gate region; other site 480224003073 putative PBP binding loops; other site 480224003074 ABC-ATPase subunit interface; other site 480224003075 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 480224003076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224003077 dimer interface [polypeptide binding]; other site 480224003078 conserved gate region; other site 480224003079 putative PBP binding loops; other site 480224003080 ABC-ATPase subunit interface; other site 480224003081 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 480224003082 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 480224003083 active site 480224003084 Predicted acyl esterases [General function prediction only]; Region: COG2936 480224003085 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 480224003086 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 480224003087 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 480224003088 Clp amino terminal domain; Region: Clp_N; pfam02861 480224003089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 480224003090 Walker A motif; other site 480224003091 ATP binding site [chemical binding]; other site 480224003092 Walker B motif; other site 480224003093 arginine finger; other site 480224003094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 480224003095 Walker A motif; other site 480224003096 ATP binding site [chemical binding]; other site 480224003097 Walker B motif; other site 480224003098 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 480224003099 GAF domain; Region: GAF; cl17456 480224003100 GAF domain; Region: GAF; pfam01590 480224003101 GAF domain; Region: GAF_2; pfam13185 480224003102 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 480224003103 RNA/DNA hybrid binding site [nucleotide binding]; other site 480224003104 active site 480224003105 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224003106 S-adenosylmethionine binding site [chemical binding]; other site 480224003107 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 480224003108 Double zinc ribbon; Region: DZR; pfam12773 480224003109 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 480224003110 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 480224003111 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 480224003112 ligand binding site [chemical binding]; other site 480224003113 flexible hinge region; other site 480224003114 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 480224003115 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 480224003116 ligand binding site [chemical binding]; other site 480224003117 flexible hinge region; other site 480224003118 hypothetical protein; Validated; Region: PRK00110 480224003119 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 480224003120 active site 480224003121 putative DNA-binding cleft [nucleotide binding]; other site 480224003122 dimer interface [polypeptide binding]; other site 480224003123 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 480224003124 cyclase homology domain; Region: CHD; cd07302 480224003125 nucleotidyl binding site; other site 480224003126 metal binding site [ion binding]; metal-binding site 480224003127 dimer interface [polypeptide binding]; other site 480224003128 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 480224003129 cyclase homology domain; Region: CHD; cd07302 480224003130 nucleotidyl binding site; other site 480224003131 dimer interface [polypeptide binding]; other site 480224003132 metal binding site [ion binding]; metal-binding site 480224003133 AAA ATPase domain; Region: AAA_16; pfam13191 480224003134 Walker A motif; other site 480224003135 ATP binding site [chemical binding]; other site 480224003136 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 480224003137 peptide binding site [polypeptide binding]; other site 480224003138 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 480224003139 adhesin; Provisional; Region: PRK09752 480224003140 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224003141 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 480224003142 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 480224003143 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 480224003144 ABC transporter; Region: ABC_tran_2; pfam12848 480224003145 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 480224003146 Subunit M of bacterial photosynthetic reaction center; Region: Photo-RC_M; cd09291 480224003147 subunit H interface; other site 480224003148 subunit L interface; other site 480224003149 bacteriopheophytin binding site; other site 480224003150 carotenoid binding site; other site 480224003151 bacteriochlorophyll binding site; other site 480224003152 cytochrome C interface; other site 480224003153 quinone binding site; other site 480224003154 Fe binding site [ion binding]; other site 480224003155 Subunit L of bacterial photosynthetic reaction center; Region: Photo-RC_L; cd09290 480224003156 subunit M interface; other site 480224003157 subunit H interface; other site 480224003158 quinone binding site; other site 480224003159 bacteriopheophytin binding site; other site 480224003160 bacteriochlorophyll binding site; other site 480224003161 cytochrome C subunit interface; other site 480224003162 Fe binding site [ion binding]; other site 480224003163 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 480224003164 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 480224003165 Probable Catalytic site; other site 480224003166 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 480224003167 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 480224003168 Bacterial sugar transferase; Region: Bac_transf; pfam02397 480224003169 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 480224003170 VanW like protein; Region: VanW; pfam04294 480224003171 G5 domain; Region: G5; pfam07501 480224003172 endonuclease IV; Provisional; Region: PRK01060 480224003173 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 480224003174 AP (apurinic/apyrimidinic) site pocket; other site 480224003175 DNA interaction; other site 480224003176 Metal-binding active site; metal-binding site 480224003177 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 480224003178 Helix-hairpin-helix motif; Region: HHH; pfam00633 480224003179 Esterase/lipase [General function prediction only]; Region: COG1647 480224003180 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224003181 GAF domain; Region: GAF_2; pfam13185 480224003182 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224003183 GAF domain; Region: GAF; pfam01590 480224003184 GAF domain; Region: GAF; pfam01590 480224003185 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 480224003186 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 480224003187 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 480224003188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 480224003189 ATP binding site [chemical binding]; other site 480224003190 Mg2+ binding site [ion binding]; other site 480224003191 G-X-G motif; other site 480224003192 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 480224003193 anti sigma factor interaction site; other site 480224003194 regulatory phosphorylation site [posttranslational modification]; other site 480224003195 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 480224003196 anti sigma factor interaction site; other site 480224003197 regulatory phosphorylation site [posttranslational modification]; other site 480224003198 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 480224003199 excinuclease ABC subunit B; Provisional; Region: PRK05298 480224003200 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 480224003201 ATP binding site [chemical binding]; other site 480224003202 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 480224003203 nucleotide binding region [chemical binding]; other site 480224003204 ATP-binding site [chemical binding]; other site 480224003205 Ultra-violet resistance protein B; Region: UvrB; pfam12344 480224003206 Nuclease-related domain; Region: NERD; pfam08378 480224003207 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 480224003208 ATP-NAD kinase; Region: NAD_kinase; pfam01513 480224003209 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 480224003210 hydrophobic ligand binding site; other site 480224003211 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 480224003212 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 480224003213 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 480224003214 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 480224003215 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 480224003216 sequence-specific DNA binding site [nucleotide binding]; other site 480224003217 salt bridge; other site 480224003218 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12858 480224003219 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 480224003220 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 480224003221 acyl-activating enzyme (AAE) consensus motif; other site 480224003222 putative AMP binding site [chemical binding]; other site 480224003223 putative active site [active] 480224003224 putative CoA binding site [chemical binding]; other site 480224003225 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 480224003226 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 480224003227 PA14 domain; Region: PA14; cl08459 480224003228 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 480224003229 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 480224003230 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 480224003231 active site 480224003232 catalytic residues [active] 480224003233 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 480224003234 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 480224003235 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 480224003236 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 480224003237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224003238 dimer interface [polypeptide binding]; other site 480224003239 conserved gate region; other site 480224003240 putative PBP binding loops; other site 480224003241 ABC-ATPase subunit interface; other site 480224003242 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 480224003243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224003244 putative PBP binding loops; other site 480224003245 dimer interface [polypeptide binding]; other site 480224003246 ABC-ATPase subunit interface; other site 480224003247 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 480224003248 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 480224003249 Transcriptional regulators [Transcription]; Region: PurR; COG1609 480224003250 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 480224003251 DNA binding site [nucleotide binding] 480224003252 domain linker motif; other site 480224003253 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 480224003254 putative dimerization interface [polypeptide binding]; other site 480224003255 putative ligand binding site [chemical binding]; other site 480224003256 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 480224003257 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 480224003258 acyl-activating enzyme (AAE) consensus motif; other site 480224003259 active site 480224003260 AMP binding site [chemical binding]; other site 480224003261 CoA binding site [chemical binding]; other site 480224003262 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 480224003263 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 480224003264 Walker A/P-loop; other site 480224003265 ATP binding site [chemical binding]; other site 480224003266 Q-loop/lid; other site 480224003267 ABC transporter signature motif; other site 480224003268 Walker B; other site 480224003269 D-loop; other site 480224003270 H-loop/switch region; other site 480224003271 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 480224003272 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 480224003273 putative ligand binding site [chemical binding]; other site 480224003274 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 480224003275 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 480224003276 TM-ABC transporter signature motif; other site 480224003277 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 480224003278 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 480224003279 TM-ABC transporter signature motif; other site 480224003280 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 480224003281 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 480224003282 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 480224003283 acyl-activating enzyme (AAE) consensus motif; other site 480224003284 putative active site [active] 480224003285 putative AMP binding site [chemical binding]; other site 480224003286 putative CoA binding site [chemical binding]; other site 480224003287 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 480224003288 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 480224003289 Walker A/P-loop; other site 480224003290 ATP binding site [chemical binding]; other site 480224003291 Q-loop/lid; other site 480224003292 ABC transporter signature motif; other site 480224003293 Walker B; other site 480224003294 D-loop; other site 480224003295 H-loop/switch region; other site 480224003296 AAK_NAGK-UC: N-Acetyl-L-glutamate kinase - uncharacterized (NAGK-UC). This domain is similar to Escherichia coli and Pseudomonas aeruginosa NAGKs which catalyze the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the...; Region: AAK_NAGK-UC; cd04251 480224003297 putative nucleotide binding site [chemical binding]; other site 480224003298 putative N-acetyl-L-glutamate binding site [chemical binding]; other site 480224003299 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 480224003300 active site 480224003301 metal binding site [ion binding]; metal-binding site 480224003302 uncharacterized subgroup of the Peptidase C25 family N-terminal domain; Region: Peptidase_C25_N_1; cd10914 480224003303 putative active site [active] 480224003304 Domain of unknown function DUF11; Region: DUF11; pfam01345 480224003305 conserved repeat domain; Region: B_ant_repeat; TIGR01451 480224003306 Domain of unknown function DUF11; Region: DUF11; pfam01345 480224003307 conserved repeat domain; Region: B_ant_repeat; TIGR01451 480224003308 Domain of unknown function DUF11; Region: DUF11; pfam01345 480224003309 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 480224003310 HYR domain; Region: HYR; pfam02494 480224003311 HYR domain; Region: HYR; pfam02494 480224003312 HYR domain; Region: HYR; pfam02494 480224003313 HYR domain; Region: HYR; pfam02494 480224003314 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 480224003315 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 480224003316 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 480224003317 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 480224003318 Walker A/P-loop; other site 480224003319 ATP binding site [chemical binding]; other site 480224003320 Q-loop/lid; other site 480224003321 ABC transporter signature motif; other site 480224003322 Walker B; other site 480224003323 D-loop; other site 480224003324 H-loop/switch region; other site 480224003325 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 480224003326 Peptidase family M23; Region: Peptidase_M23; pfam01551 480224003327 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 480224003328 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 480224003329 dimer interface [polypeptide binding]; other site 480224003330 active site 480224003331 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 480224003332 catalytic residues [active] 480224003333 substrate binding site [chemical binding]; other site 480224003334 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 480224003335 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 480224003336 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 480224003337 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 480224003338 dimerization interface [polypeptide binding]; other site 480224003339 putative active cleft [active] 480224003340 Protein of unknown function (DUF4127); Region: DUF4127; pfam13552 480224003341 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 480224003342 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 480224003343 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 480224003344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224003345 conserved gate region; other site 480224003346 dimer interface [polypeptide binding]; other site 480224003347 putative PBP binding loops; other site 480224003348 ABC-ATPase subunit interface; other site 480224003349 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 480224003350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224003351 dimer interface [polypeptide binding]; other site 480224003352 conserved gate region; other site 480224003353 putative PBP binding loops; other site 480224003354 ABC-ATPase subunit interface; other site 480224003355 alpha-mannosidase; Provisional; Region: PRK09819 480224003356 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 480224003357 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 480224003358 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 480224003359 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 480224003360 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 480224003361 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 480224003362 dimer interface [polypeptide binding]; other site 480224003363 active site 480224003364 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 480224003365 dimer interface [polypeptide binding]; other site 480224003366 active site 480224003367 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 480224003368 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 480224003369 putative NAD(P) binding site [chemical binding]; other site 480224003370 catalytic Zn binding site [ion binding]; other site 480224003371 structural Zn binding site [ion binding]; other site 480224003372 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 480224003373 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 480224003374 NADP binding site [chemical binding]; other site 480224003375 active site 480224003376 putative substrate binding site [chemical binding]; other site 480224003377 ribonuclease III; Reviewed; Region: rnc; PRK00102 480224003378 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 480224003379 dimerization interface [polypeptide binding]; other site 480224003380 active site 480224003381 metal binding site [ion binding]; metal-binding site 480224003382 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 480224003383 dsRNA binding site [nucleotide binding]; other site 480224003384 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 480224003385 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 480224003386 dimer interface [polypeptide binding]; other site 480224003387 active site 480224003388 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 480224003389 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 480224003390 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 480224003391 Peptidase family M50; Region: Peptidase_M50; pfam02163 480224003392 active site 480224003393 putative substrate binding region [chemical binding]; other site 480224003394 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 480224003395 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 480224003396 NADP-binding site; other site 480224003397 homotetramer interface [polypeptide binding]; other site 480224003398 substrate binding site [chemical binding]; other site 480224003399 homodimer interface [polypeptide binding]; other site 480224003400 active site 480224003401 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 480224003402 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 480224003403 non-specific DNA binding site [nucleotide binding]; other site 480224003404 salt bridge; other site 480224003405 sequence-specific DNA binding site [nucleotide binding]; other site 480224003406 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 480224003407 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 480224003408 CoA-ligase; Region: Ligase_CoA; pfam00549 480224003409 CTP synthetase; Validated; Region: pyrG; PRK05380 480224003410 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 480224003411 active site 480224003412 UTP binding site [chemical binding]; other site 480224003413 Catalytic site [active] 480224003414 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 480224003415 active site 480224003416 putative oxyanion hole; other site 480224003417 catalytic triad [active] 480224003418 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 480224003419 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 480224003420 RecX family; Region: RecX; cl00936 480224003421 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 480224003422 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 480224003423 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 480224003424 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 480224003425 phosphopeptide binding site; other site 480224003426 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224003427 GAF domain; Region: GAF; pfam01590 480224003428 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 480224003429 cyclase homology domain; Region: CHD; cd07302 480224003430 nucleotidyl binding site; other site 480224003431 metal binding site [ion binding]; metal-binding site 480224003432 dimer interface [polypeptide binding]; other site 480224003433 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 480224003434 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 480224003435 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 480224003436 E3 Ubiquitin ligase; Region: GIDE; pfam12483 480224003437 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_8; cd06905 480224003438 putative active site [active] 480224003439 Zn binding site [ion binding]; other site 480224003440 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 480224003441 active site 480224003442 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 480224003443 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224003444 ATP binding site [chemical binding]; other site 480224003445 Mg2+ binding site [ion binding]; other site 480224003446 G-X-G motif; other site 480224003447 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 480224003448 ATP binding site [chemical binding]; other site 480224003449 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 480224003450 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 480224003451 DHH family; Region: DHH; pfam01368 480224003452 DHHA1 domain; Region: DHHA1; pfam02272 480224003453 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 480224003454 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 480224003455 HAMP domain; Region: HAMP; pfam00672 480224003456 GAF domain; Region: GAF_3; pfam13492 480224003457 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 480224003458 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224003459 phosphorylation site [posttranslational modification] 480224003460 dimer interface [polypeptide binding]; other site 480224003461 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224003462 ATP binding site [chemical binding]; other site 480224003463 G-X-G motif; other site 480224003464 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 480224003465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224003466 active site 480224003467 phosphorylation site [posttranslational modification] 480224003468 intermolecular recognition site; other site 480224003469 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 480224003470 Probable zinc-binding domain; Region: zf-trcl; pfam13451 480224003471 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 480224003472 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 480224003473 metal binding site [ion binding]; metal-binding site 480224003474 active site 480224003475 I-site; other site 480224003476 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 480224003477 phosphoglyceromutase; Provisional; Region: PRK05434 480224003478 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 480224003479 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 480224003480 FAD binding domain; Region: FAD_binding_4; pfam01565 480224003481 FAD binding domain; Region: FAD_binding_4; pfam01565 480224003482 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 480224003483 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 480224003484 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 480224003485 Ligand binding site; other site 480224003486 Putative Catalytic site; other site 480224003487 DXD motif; other site 480224003488 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 480224003489 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 480224003490 ligand binding site [chemical binding]; other site 480224003491 flexible hinge region; other site 480224003492 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 480224003493 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 480224003494 peptide binding site [polypeptide binding]; other site 480224003495 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 480224003496 dimer interface [polypeptide binding]; other site 480224003497 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 480224003498 AAA domain; Region: AAA_22; pfam13401 480224003499 DNA adenine methylase (dam); Region: dam; TIGR00571 480224003500 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 480224003501 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 480224003502 Walker A/P-loop; other site 480224003503 ATP binding site [chemical binding]; other site 480224003504 Q-loop/lid; other site 480224003505 ABC transporter signature motif; other site 480224003506 Walker B; other site 480224003507 D-loop; other site 480224003508 H-loop/switch region; other site 480224003509 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 480224003510 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 480224003511 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 480224003512 Walker A/P-loop; other site 480224003513 ATP binding site [chemical binding]; other site 480224003514 Q-loop/lid; other site 480224003515 ABC transporter signature motif; other site 480224003516 Walker B; other site 480224003517 D-loop; other site 480224003518 H-loop/switch region; other site 480224003519 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 480224003520 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 480224003521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224003522 dimer interface [polypeptide binding]; other site 480224003523 conserved gate region; other site 480224003524 putative PBP binding loops; other site 480224003525 ABC-ATPase subunit interface; other site 480224003526 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 480224003527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224003528 dimer interface [polypeptide binding]; other site 480224003529 conserved gate region; other site 480224003530 putative PBP binding loops; other site 480224003531 ABC-ATPase subunit interface; other site 480224003532 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 480224003533 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 480224003534 substrate binding site [chemical binding]; other site 480224003535 Transcriptional regulators [Transcription]; Region: PurR; COG1609 480224003536 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 480224003537 DNA binding site [nucleotide binding] 480224003538 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 480224003539 dimerization interface [polypeptide binding]; other site 480224003540 ligand binding site [chemical binding]; other site 480224003541 Uncharacterized conserved protein [Function unknown]; Region: COG3375 480224003542 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 480224003543 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 480224003544 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 480224003545 active site 480224003546 homodimer interface [polypeptide binding]; other site 480224003547 catalytic site [active] 480224003548 acceptor binding site [chemical binding]; other site 480224003549 trehalose synthase; Region: treS_nterm; TIGR02456 480224003550 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 480224003551 active site 480224003552 catalytic site [active] 480224003553 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 480224003554 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 480224003555 glycogen branching enzyme; Provisional; Region: PRK12313 480224003556 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 480224003557 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 480224003558 active site 480224003559 catalytic site [active] 480224003560 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 480224003561 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 480224003562 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 480224003563 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 480224003564 catalytic site [active] 480224003565 active site 480224003566 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 480224003567 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 480224003568 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 480224003569 active site 480224003570 catalytic site [active] 480224003571 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 480224003572 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 480224003573 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 480224003574 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 480224003575 active site 480224003576 catalytic site [active] 480224003577 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 480224003578 [2Fe-2S] cluster binding site [ion binding]; other site 480224003579 adenylosuccinate lyase; Provisional; Region: PRK09285 480224003580 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 480224003581 active site 480224003582 tetramer interface [polypeptide binding]; other site 480224003583 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 480224003584 MarR family; Region: MarR; pfam01047 480224003585 HlyD family secretion protein; Region: HlyD_3; pfam13437 480224003586 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 480224003587 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 480224003588 FtsX-like permease family; Region: FtsX; pfam02687 480224003589 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 480224003590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 480224003591 NAD(P) binding site [chemical binding]; other site 480224003592 active site 480224003593 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224003594 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224003595 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 480224003596 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 480224003597 putative active site [active] 480224003598 heme pocket [chemical binding]; other site 480224003599 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224003600 dimer interface [polypeptide binding]; other site 480224003601 phosphorylation site [posttranslational modification] 480224003602 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224003603 ATP binding site [chemical binding]; other site 480224003604 Mg2+ binding site [ion binding]; other site 480224003605 G-X-G motif; other site 480224003606 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 480224003607 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 480224003608 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224003609 homodimer interface [polypeptide binding]; other site 480224003610 catalytic residue [active] 480224003611 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 480224003612 Double zinc ribbon; Region: DZR; pfam12773 480224003613 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 480224003614 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 480224003615 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 480224003616 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 480224003617 Predicted transcriptional regulator [Transcription]; Region: COG2345 480224003618 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 480224003619 putative DNA binding site [nucleotide binding]; other site 480224003620 putative Zn2+ binding site [ion binding]; other site 480224003621 antiporter inner membrane protein; Provisional; Region: PRK11670 480224003622 Domain of unknown function DUF59; Region: DUF59; pfam01883 480224003623 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 480224003624 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 480224003625 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 480224003626 FeS/SAM binding site; other site 480224003627 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 480224003628 heat shock protein 90; Provisional; Region: PRK05218 480224003629 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224003630 ATP binding site [chemical binding]; other site 480224003631 Mg2+ binding site [ion binding]; other site 480224003632 G-X-G motif; other site 480224003633 Major Facilitator Superfamily; Region: MFS_1; pfam07690 480224003634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 480224003635 putative substrate translocation pore; other site 480224003636 Colicin V production protein; Region: Colicin_V; pfam02674 480224003637 MutS domain III; Region: MutS_III; pfam05192 480224003638 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 480224003639 Walker A/P-loop; other site 480224003640 ATP binding site [chemical binding]; other site 480224003641 Q-loop/lid; other site 480224003642 ABC transporter signature motif; other site 480224003643 Walker B; other site 480224003644 D-loop; other site 480224003645 H-loop/switch region; other site 480224003646 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 480224003647 heterodimer interface [polypeptide binding]; other site 480224003648 homodimer interface [polypeptide binding]; other site 480224003649 Smr domain; Region: Smr; pfam01713 480224003650 bidirectional hydrogenase complex protein HoxE; Reviewed; Region: PRK07571 480224003651 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 480224003652 putative dimer interface [polypeptide binding]; other site 480224003653 [2Fe-2S] cluster binding site [ion binding]; other site 480224003654 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 480224003655 dimer interface [polypeptide binding]; other site 480224003656 [2Fe-2S] cluster binding site [ion binding]; other site 480224003657 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 480224003658 SLBB domain; Region: SLBB; pfam10531 480224003659 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 480224003660 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 480224003661 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 480224003662 catalytic loop [active] 480224003663 iron binding site [ion binding]; other site 480224003664 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 480224003665 Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941 480224003666 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 480224003667 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 480224003668 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 480224003669 Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066 480224003670 nickel binding site [ion binding]; other site 480224003671 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 480224003672 Protein of unknown function (DUF4013); Region: DUF4013; pfam13197 480224003673 Protein of unknown function (DUF4013); Region: DUF4013; pfam13197 480224003674 competence damage-inducible protein A; Provisional; Region: PRK00549 480224003675 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 480224003676 putative MPT binding site; other site 480224003677 Competence-damaged protein; Region: CinA; cl00666 480224003678 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 480224003679 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 480224003680 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 480224003681 active site 480224003682 dimer interface [polypeptide binding]; other site 480224003683 motif 1; other site 480224003684 motif 2; other site 480224003685 motif 3; other site 480224003686 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 480224003687 anticodon binding site; other site 480224003688 Cobalt transport protein; Region: CbiQ; cl00463 480224003689 cobalamin synthase; Reviewed; Region: cobS; PRK00235 480224003690 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 480224003691 catalytic core [active] 480224003692 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 480224003693 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 480224003694 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 480224003695 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 480224003696 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 480224003697 Probable transposase; Region: OrfB_IS605; pfam01385 480224003698 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 480224003699 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 480224003700 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 480224003701 catalytic residues [active] 480224003702 catalytic nucleophile [active] 480224003703 acetyl-lysine deacetylase; Provisional; Region: PRK04443 480224003704 M20 Peptidase acetylornithine deacetylase/acetyl-lysine deacetylase; Region: M20_ArgE_LysK; cd05653 480224003705 metal binding site [ion binding]; metal-binding site 480224003706 putative dimer interface [polypeptide binding]; other site 480224003707 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 480224003708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 480224003709 ATP binding site [chemical binding]; other site 480224003710 Mg2+ binding site [ion binding]; other site 480224003711 G-X-G motif; other site 480224003712 YcxB-like protein; Region: YcxB; pfam14317 480224003713 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 480224003714 AAA domain; Region: AAA_12; pfam13087 480224003715 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 480224003716 Histidine kinase; Region: HisKA_3; pfam07730 480224003717 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 480224003718 Arsenite oxidase (Arsenite-Ox) oxidizes arsenite to the less toxic arsenate; it transfers the electrons obtained from the oxidation of arsenite towards the soluble periplasmic electron carriers cytochrome c and/or amicyanin. Arsenite oxidase is a...; Region: MopB_Arsenite-Ox; cd02756 480224003719 arsenite oxidase, large subunit; Region: arsenite_ox_L; TIGR02693 480224003720 [3Fe-4S] binding site [ion binding]; other site 480224003721 molybdopterin cofactor binding site [chemical binding]; other site 480224003722 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of Arsenite oxidase (Arsenite-Ox) and related proteins. Arsenite oxidase oxidizes arsenite to the less toxic arsenate; it transfers the electrons obtained from the oxidation of...; Region: MopB_CT_Arsenite-Ox; cd02779 480224003723 molybdopterin cofactor binding site; other site 480224003724 Small subunit of Arsenite oxidase (ArOX) family, Rieske domain; ArOX is a molybdenum/iron protein involved in the detoxification of arsenic, oxidizing it to arsenate. It consists of two subunits, a large subunit similar to members of the DMSO reductase...; Region: Rieske_ArOX_small; cd03476 480224003725 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 480224003726 [2Fe-2S] cluster binding site [ion binding]; other site 480224003727 subunit interaction site [polypeptide binding]; other site 480224003728 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 480224003729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224003730 active site 480224003731 phosphorylation site [posttranslational modification] 480224003732 intermolecular recognition site; other site 480224003733 dimerization interface [polypeptide binding]; other site 480224003734 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 480224003735 dimerization interface [polypeptide binding]; other site 480224003736 DNA binding residues [nucleotide binding] 480224003737 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 480224003738 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 480224003739 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 480224003740 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 480224003741 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 480224003742 motif II; other site 480224003743 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 480224003744 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 480224003745 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 480224003746 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 480224003747 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 480224003748 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 480224003749 extended (e) SDRs; Region: SDR_e; cd08946 480224003750 NAD(P) binding site [chemical binding]; other site 480224003751 active site 480224003752 substrate binding site [chemical binding]; other site 480224003753 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 480224003754 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 480224003755 substrate binding site; other site 480224003756 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 480224003757 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 480224003758 NAD binding site [chemical binding]; other site 480224003759 putative substrate binding site 2 [chemical binding]; other site 480224003760 putative substrate binding site 1 [chemical binding]; other site 480224003761 active site 480224003762 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 480224003763 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 480224003764 NAD(P) binding site [chemical binding]; other site 480224003765 active site 480224003766 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 480224003767 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 480224003768 inhibitor-cofactor binding pocket; inhibition site 480224003769 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224003770 catalytic residue [active] 480224003771 Flp/Fap pilin component; Region: Flp_Fap; cl01585 480224003772 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 480224003773 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 480224003774 ligand binding site [chemical binding]; other site 480224003775 flexible hinge region; other site 480224003776 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 480224003777 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 480224003778 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 480224003779 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 480224003780 putative acyl-acceptor binding pocket; other site 480224003781 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 480224003782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 480224003783 NAD(P) binding site [chemical binding]; other site 480224003784 active site 480224003785 Fic/DOC family; Region: Fic; cl00960 480224003786 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 480224003787 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 480224003788 dimer interface [polypeptide binding]; other site 480224003789 putative anticodon binding site; other site 480224003790 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 480224003791 motif 1; other site 480224003792 active site 480224003793 motif 2; other site 480224003794 motif 3; other site 480224003795 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 480224003796 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 480224003797 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 480224003798 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 480224003799 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 480224003800 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 480224003801 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 480224003802 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 480224003803 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 480224003804 Metallopeptidase family M24; Region: Peptidase_M24; pfam00557 480224003805 active site 480224003806 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 480224003807 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 480224003808 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 480224003809 Sulfate transporter family; Region: Sulfate_transp; pfam00916 480224003810 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 480224003811 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 480224003812 active site residue [active] 480224003813 fructose 1,6-bisphosphatase II; Reviewed; Region: glpX; PRK09479 480224003814 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 480224003815 active site 480224003816 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 480224003817 TRAM domain; Region: TRAM; pfam01938 480224003818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224003819 S-adenosylmethionine binding site [chemical binding]; other site 480224003820 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 480224003821 Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154 480224003822 Rab subfamily motif 1 (RabSF1); other site 480224003823 G1 box; other site 480224003824 GTP/Mg2+ binding site [chemical binding]; other site 480224003825 Rab subfamily motif 2 (RabSF2); other site 480224003826 Switch I region; other site 480224003827 G2 box; other site 480224003828 effector interaction site; other site 480224003829 GDI interaction site; other site 480224003830 Rab family motif 1 (RabF1); other site 480224003831 GEF interaction site [polypeptide binding]; other site 480224003832 Rab family motif 2 (RabF2); other site 480224003833 G3 box; other site 480224003834 Switch II region; other site 480224003835 Rab family motif 3 (RabF3); other site 480224003836 Rab family motif 4 (RabF4); other site 480224003837 Rab family motif 5 (RabF5); other site 480224003838 Rab subfamily motif 3 (RabSF3); other site 480224003839 G4 box; other site 480224003840 G5 box; other site 480224003841 Rab subfamily motif 4 (RabSF4); other site 480224003842 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 480224003843 PAS domain; Region: PAS_9; pfam13426 480224003844 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224003845 dimer interface [polypeptide binding]; other site 480224003846 phosphorylation site [posttranslational modification] 480224003847 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224003848 ATP binding site [chemical binding]; other site 480224003849 Mg2+ binding site [ion binding]; other site 480224003850 G-X-G motif; other site 480224003851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224003852 active site 480224003853 phosphorylation site [posttranslational modification] 480224003854 intermolecular recognition site; other site 480224003855 dimerization interface [polypeptide binding]; other site 480224003856 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 480224003857 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 480224003858 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 480224003859 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 480224003860 DNA gyrase subunit A; Validated; Region: PRK05560 480224003861 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 480224003862 CAP-like domain; other site 480224003863 active site 480224003864 primary dimer interface [polypeptide binding]; other site 480224003865 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 480224003866 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 480224003867 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 480224003868 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 480224003869 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 480224003870 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 480224003871 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 480224003872 DNA methylase; Region: N6_N4_Mtase; pfam01555 480224003873 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 480224003874 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 480224003875 catalytic residues [active] 480224003876 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 480224003877 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224003878 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 480224003879 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 480224003880 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 480224003881 Coenzyme A binding pocket [chemical binding]; other site 480224003882 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 480224003883 GTPase RsgA; Reviewed; Region: PRK00098 480224003884 RNA binding site [nucleotide binding]; other site 480224003885 homodimer interface [polypeptide binding]; other site 480224003886 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 480224003887 GTPase/Zn-binding domain interface [polypeptide binding]; other site 480224003888 GTP/Mg2+ binding site [chemical binding]; other site 480224003889 G4 box; other site 480224003890 G5 box; other site 480224003891 G1 box; other site 480224003892 Switch I region; other site 480224003893 G2 box; other site 480224003894 G3 box; other site 480224003895 Switch II region; other site 480224003896 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 480224003897 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 480224003898 tetramer interface [polypeptide binding]; other site 480224003899 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224003900 catalytic residue [active] 480224003901 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 480224003902 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 480224003903 active site 480224003904 catalytic tetrad [active] 480224003905 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 480224003906 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 480224003907 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 480224003908 putative RNA binding site [nucleotide binding]; other site 480224003909 S-adenosylmethionine binding site [chemical binding]; other site 480224003910 Methyltransferase domain; Region: Methyltransf_26; pfam13659 480224003911 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 480224003912 heterotetramer interface [polypeptide binding]; other site 480224003913 active site pocket [active] 480224003914 cleavage site 480224003915 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 480224003916 Protein of unknown function (DUF503); Region: DUF503; pfam04456 480224003917 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 480224003918 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 480224003919 Walker A motif; other site 480224003920 ATP binding site [chemical binding]; other site 480224003921 Walker B motif; other site 480224003922 arginine finger; other site 480224003923 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 480224003924 kynureninase; Region: kynureninase; TIGR01814 480224003925 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 480224003926 catalytic residue [active] 480224003927 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 480224003928 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 480224003929 Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Ade5; cd01416 480224003930 ATP binding site [chemical binding]; other site 480224003931 active site 480224003932 substrate binding site [chemical binding]; other site 480224003933 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 480224003934 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 480224003935 dimerization interface [polypeptide binding]; other site 480224003936 putative ATP binding site [chemical binding]; other site 480224003937 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 480224003938 ATP phosphoribosyltransferase; Region: HisG; cl15266 480224003939 HisG, C-terminal domain; Region: HisG_C; cl06867 480224003940 Creatinine amidohydrolase; Region: Creatininase; cl00618 480224003941 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 480224003942 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 480224003943 dimer interface [polypeptide binding]; other site 480224003944 motif 1; other site 480224003945 motif 2; other site 480224003946 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 480224003947 motif 3; other site 480224003948 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 480224003949 anticodon binding site; other site 480224003950 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 480224003951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224003952 active site 480224003953 phosphorylation site [posttranslational modification] 480224003954 intermolecular recognition site; other site 480224003955 dimerization interface [polypeptide binding]; other site 480224003956 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224003957 dimer interface [polypeptide binding]; other site 480224003958 phosphorylation site [posttranslational modification] 480224003959 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224003960 ATP binding site [chemical binding]; other site 480224003961 Mg2+ binding site [ion binding]; other site 480224003962 G-X-G motif; other site 480224003963 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 480224003964 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 480224003965 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 480224003966 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 480224003967 metal ion-dependent adhesion site (MIDAS); other site 480224003968 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 480224003969 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 480224003970 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 480224003971 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224003972 dimer interface [polypeptide binding]; other site 480224003973 putative PBP binding loops; other site 480224003974 ABC-ATPase subunit interface; other site 480224003975 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 480224003976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224003977 dimer interface [polypeptide binding]; other site 480224003978 conserved gate region; other site 480224003979 putative PBP binding loops; other site 480224003980 ABC-ATPase subunit interface; other site 480224003981 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 480224003982 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 480224003983 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 480224003984 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 480224003985 RNA/DNA hybrid binding site [nucleotide binding]; other site 480224003986 active site 480224003987 dihydrodipicolinate reductase; Provisional; Region: PRK00048 480224003988 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 480224003989 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 480224003990 DinB superfamily; Region: DinB_2; pfam12867 480224003991 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 480224003992 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 480224003993 ligand binding site [chemical binding]; other site 480224003994 flexible hinge region; other site 480224003995 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 480224003996 putative switch regulator; other site 480224003997 non-specific DNA interactions [nucleotide binding]; other site 480224003998 DNA binding site [nucleotide binding] 480224003999 sequence specific DNA binding site [nucleotide binding]; other site 480224004000 putative cAMP binding site [chemical binding]; other site 480224004001 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 480224004002 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 480224004003 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 480224004004 Peptidase family U32; Region: Peptidase_U32; pfam01136 480224004005 Collagenase; Region: DUF3656; pfam12392 480224004006 Quinolinate phosphoribosyl transferase, C-terminal domain; Region: QRPTase_C; pfam01729 480224004007 Peptidase family U32; Region: Peptidase_U32; pfam01136 480224004008 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 480224004009 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 480224004010 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 480224004011 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 480224004012 Catalytic site [active] 480224004013 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 480224004014 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224004015 GTPase CgtA; Reviewed; Region: obgE; PRK12297 480224004016 GTP1/OBG; Region: GTP1_OBG; pfam01018 480224004017 Obg GTPase; Region: Obg; cd01898 480224004018 G1 box; other site 480224004019 GTP/Mg2+ binding site [chemical binding]; other site 480224004020 Switch I region; other site 480224004021 G2 box; other site 480224004022 G3 box; other site 480224004023 Switch II region; other site 480224004024 G4 box; other site 480224004025 G5 box; other site 480224004026 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 480224004027 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 480224004028 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 480224004029 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 480224004030 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 480224004031 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 480224004032 active site 480224004033 DNA binding site [nucleotide binding] 480224004034 Int/Topo IB signature motif; other site 480224004035 PAS fold; Region: PAS_3; pfam08447 480224004036 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224004037 putative active site [active] 480224004038 heme pocket [chemical binding]; other site 480224004039 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 480224004040 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 480224004041 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 480224004042 NAD(P) binding site [chemical binding]; other site 480224004043 active site 480224004044 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 480224004045 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 480224004046 putative ADP-ribose binding site [chemical binding]; other site 480224004047 putative active site [active] 480224004048 PspC domain; Region: PspC; pfam04024 480224004049 Integral membrane protein DUF92; Region: DUF92; pfam01940 480224004050 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 480224004051 hydrophobic ligand binding site; other site 480224004052 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 480224004053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 480224004054 putative substrate translocation pore; other site 480224004055 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 480224004056 Coenzyme A binding pocket [chemical binding]; other site 480224004057 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 480224004058 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 480224004059 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 480224004060 FeS/SAM binding site; other site 480224004061 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 480224004062 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 480224004063 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 480224004064 VanW like protein; Region: VanW; pfam04294 480224004065 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 480224004066 Histidine kinase; Region: HisKA_3; pfam07730 480224004067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224004068 ATP binding site [chemical binding]; other site 480224004069 Mg2+ binding site [ion binding]; other site 480224004070 G-X-G motif; other site 480224004071 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 480224004072 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 480224004073 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 480224004074 dimerization interface [polypeptide binding]; other site 480224004075 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 480224004076 Part of AAA domain; Region: AAA_19; pfam13245 480224004077 Family description; Region: UvrD_C_2; pfam13538 480224004078 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 480224004079 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 480224004080 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 480224004081 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 480224004082 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 480224004083 prolyl-tRNA synthetase; Provisional; Region: PRK08661 480224004084 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 480224004085 dimer interface [polypeptide binding]; other site 480224004086 motif 1; other site 480224004087 active site 480224004088 motif 2; other site 480224004089 motif 3; other site 480224004090 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 480224004091 anticodon binding site; other site 480224004092 zinc-binding site [ion binding]; other site 480224004093 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 480224004094 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 480224004095 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 480224004096 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 480224004097 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 480224004098 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 480224004099 Ca binding site [ion binding]; other site 480224004100 active site 480224004101 catalytic site [active] 480224004102 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 480224004103 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 480224004104 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 480224004105 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 480224004106 putative active site [active] 480224004107 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 480224004108 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 480224004109 putative ADP-binding pocket [chemical binding]; other site 480224004110 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 480224004111 Ligand binding site; other site 480224004112 Putative Catalytic site; other site 480224004113 DXD motif; other site 480224004114 DAK2 domain; Region: Dak2; cl03685 480224004115 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 480224004116 active pocket/dimerization site; other site 480224004117 active site 480224004118 phosphorylation site [posttranslational modification] 480224004119 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 480224004120 dimerization domain swap beta strand [polypeptide binding]; other site 480224004121 regulatory protein interface [polypeptide binding]; other site 480224004122 active site 480224004123 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 480224004124 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 480224004125 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 480224004126 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 480224004127 Cupin domain; Region: Cupin_2; pfam07883 480224004128 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 480224004129 dimerization interface [polypeptide binding]; other site 480224004130 putative DNA binding site [nucleotide binding]; other site 480224004131 putative Zn2+ binding site [ion binding]; other site 480224004132 Low molecular weight phosphatase family; Region: LMWPc; cd00115 480224004133 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 480224004134 active site 480224004135 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 480224004136 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 480224004137 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 480224004138 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 480224004139 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 480224004140 dimerization domain swap beta strand [polypeptide binding]; other site 480224004141 regulatory protein interface [polypeptide binding]; other site 480224004142 active site 480224004143 regulatory phosphorylation site [posttranslational modification]; other site 480224004144 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 480224004145 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 480224004146 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 480224004147 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 480224004148 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 480224004149 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 480224004150 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 480224004151 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 480224004152 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 480224004153 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 480224004154 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 480224004155 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 480224004156 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 480224004157 E3 interaction surface; other site 480224004158 lipoyl attachment site [posttranslational modification]; other site 480224004159 e3 binding domain; Region: E3_binding; pfam02817 480224004160 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 480224004161 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 480224004162 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 480224004163 alpha subunit interface [polypeptide binding]; other site 480224004164 TPP binding site [chemical binding]; other site 480224004165 heterodimer interface [polypeptide binding]; other site 480224004166 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 480224004167 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 480224004168 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 480224004169 tetramer interface [polypeptide binding]; other site 480224004170 TPP-binding site [chemical binding]; other site 480224004171 heterodimer interface [polypeptide binding]; other site 480224004172 phosphorylation loop region [posttranslational modification] 480224004173 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 480224004174 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 480224004175 DNA binding residues [nucleotide binding] 480224004176 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 480224004177 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 480224004178 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 480224004179 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 480224004180 Chlor_Arch_YYY domain; Region: Chlor_Arch_YYY; TIGR03662 480224004181 Uncharacterized membrane protein (DUF2298); Region: DUF2298; pfam10060 480224004182 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 480224004183 Chlor_Arch_YYY domain; Region: Chlor_Arch_YYY; TIGR03662 480224004184 Uncharacterized membrane protein (DUF2298); Region: DUF2298; pfam10060 480224004185 Chlor_Arch_YYY domain; Region: Chlor_Arch_YYY; TIGR03662 480224004186 Uncharacterized membrane protein (DUF2298); Region: DUF2298; pfam10060 480224004187 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224004188 binding surface 480224004189 TPR motif; other site 480224004190 TPR repeat; Region: TPR_11; pfam13414 480224004191 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224004192 TPR motif; other site 480224004193 binding surface 480224004194 TPR repeat; Region: TPR_11; pfam13414 480224004195 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 480224004196 dimer interface [polypeptide binding]; other site 480224004197 [2Fe-2S] cluster binding site [ion binding]; other site 480224004198 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 480224004199 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 480224004200 dimer interface [polypeptide binding]; other site 480224004201 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224004202 catalytic residue [active] 480224004203 Uncharacterized conserved protein [Function unknown]; Region: COG3379 480224004204 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 480224004205 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 480224004206 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 480224004207 Sulfatase; Region: Sulfatase; cl17466 480224004208 enoyl-CoA hydratase; Validated; Region: PRK08139 480224004209 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 480224004210 substrate binding site [chemical binding]; other site 480224004211 oxyanion hole (OAH) forming residues; other site 480224004212 trimer interface [polypeptide binding]; other site 480224004213 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 480224004214 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 480224004215 N-terminal, non-catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_N_like; cd09013 480224004216 tetramer interface [polypeptide binding]; other site 480224004217 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 480224004218 C-terminal, catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_C_like; cd09014 480224004219 tetramer interface [polypeptide binding]; other site 480224004220 active site 480224004221 metal binding site [ion binding]; metal-binding site 480224004222 Transcriptional regulator [Transcription]; Region: IclR; COG1414 480224004223 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 480224004224 Bacterial transcriptional regulator; Region: IclR; pfam01614 480224004225 acetaldehyde dehydrogenase; Validated; Region: PRK08300 480224004226 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 480224004227 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 480224004228 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 480224004229 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 480224004230 active site 480224004231 catalytic residues [active] 480224004232 metal binding site [ion binding]; metal-binding site 480224004233 DmpG-like communication domain; Region: DmpG_comm; pfam07836 480224004234 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 480224004235 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 480224004236 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 480224004237 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 480224004238 dimer interface [polypeptide binding]; other site 480224004239 hexamer interface [polypeptide binding]; other site 480224004240 active site 2 [active] 480224004241 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 480224004242 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 480224004243 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 480224004244 NAD binding site [chemical binding]; other site 480224004245 catalytic residues [active] 480224004246 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 480224004247 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 480224004248 recombinase A; Provisional; Region: recA; PRK09354 480224004249 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 480224004250 hexamer interface [polypeptide binding]; other site 480224004251 Walker A motif; other site 480224004252 ATP binding site [chemical binding]; other site 480224004253 Walker B motif; other site 480224004254 Domain of unknown function (DUF427); Region: DUF427; cl00998 480224004255 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 480224004256 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 480224004257 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 480224004258 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 480224004259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224004260 ABC-ATPase subunit interface; other site 480224004261 putative PBP binding loops; other site 480224004262 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 480224004263 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 480224004264 Walker A/P-loop; other site 480224004265 ATP binding site [chemical binding]; other site 480224004266 Q-loop/lid; other site 480224004267 ABC transporter signature motif; other site 480224004268 Walker B; other site 480224004269 D-loop; other site 480224004270 H-loop/switch region; other site 480224004271 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 480224004272 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 480224004273 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 480224004274 Walker A/P-loop; other site 480224004275 ATP binding site [chemical binding]; other site 480224004276 Q-loop/lid; other site 480224004277 ABC transporter signature motif; other site 480224004278 Walker B; other site 480224004279 D-loop; other site 480224004280 H-loop/switch region; other site 480224004281 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 480224004282 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 480224004283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224004284 dimer interface [polypeptide binding]; other site 480224004285 conserved gate region; other site 480224004286 putative PBP binding loops; other site 480224004287 ABC-ATPase subunit interface; other site 480224004288 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 480224004289 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 480224004290 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 480224004291 Walker A motif; other site 480224004292 ATP binding site [chemical binding]; other site 480224004293 Walker B motif; other site 480224004294 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 480224004295 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 480224004296 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 480224004297 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 480224004298 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224004299 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 480224004300 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 480224004301 CARDB; Region: CARDB; pfam07705 480224004302 Methyltransferase domain; Region: Methyltransf_23; pfam13489 480224004303 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224004304 S-adenosylmethionine binding site [chemical binding]; other site 480224004305 NAD synthetase; Reviewed; Region: nadE; PRK02628 480224004306 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 480224004307 multimer interface [polypeptide binding]; other site 480224004308 active site 480224004309 catalytic triad [active] 480224004310 protein interface 1 [polypeptide binding]; other site 480224004311 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 480224004312 homodimer interface [polypeptide binding]; other site 480224004313 NAD binding pocket [chemical binding]; other site 480224004314 ATP binding pocket [chemical binding]; other site 480224004315 Mg binding site [ion binding]; other site 480224004316 active-site loop [active] 480224004317 succinic semialdehyde dehydrogenase; Region: PLN02278 480224004318 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 480224004319 tetramerization interface [polypeptide binding]; other site 480224004320 NAD(P) binding site [chemical binding]; other site 480224004321 catalytic residues [active] 480224004322 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 480224004323 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 480224004324 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 480224004325 Amidase; Region: Amidase; pfam01425 480224004326 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 480224004327 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 480224004328 ATP-grasp domain; Region: ATP-grasp_4; cl17255 480224004329 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 480224004330 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 480224004331 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 480224004332 carboxyltransferase (CT) interaction site; other site 480224004333 biotinylation site [posttranslational modification]; other site 480224004334 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224004335 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 480224004336 putative hydrolase; Provisional; Region: PRK02113 480224004337 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 480224004338 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 480224004339 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 480224004340 dimerization interface [polypeptide binding]; other site 480224004341 PAS domain; Region: PAS; smart00091 480224004342 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224004343 dimer interface [polypeptide binding]; other site 480224004344 phosphorylation site [posttranslational modification] 480224004345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224004346 ATP binding site [chemical binding]; other site 480224004347 Mg2+ binding site [ion binding]; other site 480224004348 G-X-G motif; other site 480224004349 Calx-beta domain; Region: Calx-beta; pfam03160 480224004350 Calx-beta domain; Region: Calx-beta; cl02522 480224004351 Calx-beta domain; Region: Calx-beta; cl02522 480224004352 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 480224004353 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 480224004354 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 480224004355 active site 480224004356 ribulose/triose binding site [chemical binding]; other site 480224004357 phosphate binding site [ion binding]; other site 480224004358 substrate (anthranilate) binding pocket [chemical binding]; other site 480224004359 product (indole) binding pocket [chemical binding]; other site 480224004360 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 480224004361 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 480224004362 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 480224004363 30S subunit binding site; other site 480224004364 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 480224004365 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 480224004366 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 480224004367 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 480224004368 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 480224004369 Histidine kinase; Region: HisKA_3; pfam07730 480224004370 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 480224004371 Mg2+ binding site [ion binding]; other site 480224004372 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 480224004373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224004374 active site 480224004375 phosphorylation site [posttranslational modification] 480224004376 intermolecular recognition site; other site 480224004377 dimerization interface [polypeptide binding]; other site 480224004378 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 480224004379 DNA binding residues [nucleotide binding] 480224004380 dimerization interface [polypeptide binding]; other site 480224004381 cyclase homology domain; Region: CHD; cd07302 480224004382 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 480224004383 nucleotidyl binding site; other site 480224004384 metal binding site [ion binding]; metal-binding site 480224004385 dimer interface [polypeptide binding]; other site 480224004386 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 480224004387 cyclase homology domain; Region: CHD; cd07302 480224004388 nucleotidyl binding site; other site 480224004389 metal binding site [ion binding]; metal-binding site 480224004390 dimer interface [polypeptide binding]; other site 480224004391 AAA ATPase domain; Region: AAA_16; pfam13191 480224004392 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224004393 TPR motif; other site 480224004394 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224004395 binding surface 480224004396 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224004397 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224004398 binding surface 480224004399 TPR motif; other site 480224004400 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224004401 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224004402 Quinolinate synthetase A protein; Region: NadA; pfam02445 480224004403 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 480224004404 L-aspartate oxidase; Provisional; Region: PRK06175 480224004405 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 480224004406 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 480224004407 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 480224004408 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 480224004409 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 480224004410 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 480224004411 DNA binding site [nucleotide binding] 480224004412 active site 480224004413 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 480224004414 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 480224004415 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 480224004416 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 480224004417 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 480224004418 active site 480224004419 HIGH motif; other site 480224004420 dimer interface [polypeptide binding]; other site 480224004421 KMSKS motif; other site 480224004422 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 480224004423 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 480224004424 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224004425 catalytic residue [active] 480224004426 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 480224004427 phytoene desaturase; Region: crtI_fam; TIGR02734 480224004428 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 480224004429 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 480224004430 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 480224004431 Predicted membrane protein [Function unknown]; Region: COG3174 480224004432 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 480224004433 Phospholipid methyltransferase; Region: PEMT; cl17370 480224004434 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14604 480224004435 RuvA N terminal domain; Region: RuvA_N; pfam01330 480224004436 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 480224004437 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 480224004438 active site 480224004439 Bifunctional nuclease; Region: DNase-RNase; pfam02577 480224004440 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 480224004441 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 480224004442 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 480224004443 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 480224004444 Bacterial SH3 domain; Region: SH3_3; pfam08239 480224004445 Peptidase family M23; Region: Peptidase_M23; pfam01551 480224004446 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 480224004447 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 480224004448 P-loop; other site 480224004449 Magnesium ion binding site [ion binding]; other site 480224004450 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 480224004451 Magnesium ion binding site [ion binding]; other site 480224004452 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 480224004453 ParB-like nuclease domain; Region: ParBc; pfam02195 480224004454 Ribokinase-like subgroup D. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_D; cd01937 480224004455 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 480224004456 substrate binding site [chemical binding]; other site 480224004457 ATP binding site [chemical binding]; other site 480224004458 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 480224004459 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 480224004460 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 480224004461 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 480224004462 putative dimer interface [polypeptide binding]; other site 480224004463 putative anticodon binding site; other site 480224004464 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 480224004465 homodimer interface [polypeptide binding]; other site 480224004466 motif 1; other site 480224004467 motif 2; other site 480224004468 active site 480224004469 motif 3; other site 480224004470 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 480224004471 M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896 480224004472 putative metal binding site [ion binding]; other site 480224004473 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 480224004474 active site 480224004475 catalytic site [active] 480224004476 Methyltransferase domain; Region: Methyltransf_31; pfam13847 480224004477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224004478 S-adenosylmethionine binding site [chemical binding]; other site 480224004479 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 480224004480 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 480224004481 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 480224004482 homodimer interface [polypeptide binding]; other site 480224004483 substrate-cofactor binding pocket; other site 480224004484 catalytic residue [active] 480224004485 multidrug resistance protein MdtH; Provisional; Region: PRK11646 480224004486 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224004487 S-adenosylmethionine binding site [chemical binding]; other site 480224004488 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 480224004489 Zn binding site [ion binding]; other site 480224004490 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 480224004491 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 480224004492 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 480224004493 Zn2+ binding site [ion binding]; other site 480224004494 Mg2+ binding site [ion binding]; other site 480224004495 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 480224004496 synthetase active site [active] 480224004497 NTP binding site [chemical binding]; other site 480224004498 metal binding site [ion binding]; metal-binding site 480224004499 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 480224004500 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 480224004501 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 480224004502 endonuclease III; Region: ENDO3c; smart00478 480224004503 minor groove reading motif; other site 480224004504 helix-hairpin-helix signature motif; other site 480224004505 substrate binding pocket [chemical binding]; other site 480224004506 active site 480224004507 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 480224004508 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224004509 GAF domain; Region: GAF_3; pfam13492 480224004510 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224004511 dimer interface [polypeptide binding]; other site 480224004512 phosphorylation site [posttranslational modification] 480224004513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224004514 ATP binding site [chemical binding]; other site 480224004515 Mg2+ binding site [ion binding]; other site 480224004516 G-X-G motif; other site 480224004517 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224004518 active site 480224004519 phosphorylation site [posttranslational modification] 480224004520 intermolecular recognition site; other site 480224004521 dimerization interface [polypeptide binding]; other site 480224004522 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 480224004523 Aspartase; Region: Aspartase; cd01357 480224004524 active sites [active] 480224004525 tetramer interface [polypeptide binding]; other site 480224004526 PGAP1-like protein; Region: PGAP1; pfam07819 480224004527 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 480224004528 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 480224004529 G8 domain; Region: G8; pfam10162 480224004530 Right handed beta helix region; Region: Beta_helix; pfam13229 480224004531 glutamine synthetase, type I; Region: GlnA; TIGR00653 480224004532 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 480224004533 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 480224004534 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 480224004535 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 480224004536 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 480224004537 catalytic residue [active] 480224004538 CRISPR/Cas system-associated protein Csx15; Region: Csx15_I-U; cd09766 480224004539 META domain; Region: META; pfam03724 480224004540 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 480224004541 active site 480224004542 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 480224004543 FAD binding site [chemical binding]; other site 480224004544 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 480224004545 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 480224004546 homodimer interface [polypeptide binding]; other site 480224004547 substrate-cofactor binding pocket; other site 480224004548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224004549 catalytic residue [active] 480224004550 Methyltransferase domain; Region: Methyltransf_23; pfam13489 480224004551 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224004552 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 480224004553 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 480224004554 Coenzyme A binding pocket [chemical binding]; other site 480224004555 beta-ketothiolase; Provisional; Region: PRK09051 480224004556 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 480224004557 dimer interface [polypeptide binding]; other site 480224004558 active site 480224004559 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 480224004560 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 480224004561 NAD(P) binding site [chemical binding]; other site 480224004562 homotetramer interface [polypeptide binding]; other site 480224004563 homodimer interface [polypeptide binding]; other site 480224004564 active site 480224004565 AAA domain; Region: AAA_22; pfam13401 480224004566 AAA ATPase domain; Region: AAA_16; pfam13191 480224004567 Bacterial transcriptional activator domain; Region: BTAD; smart01043 480224004568 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 480224004569 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 480224004570 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 480224004571 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 480224004572 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 480224004573 Probable Catalytic site; other site 480224004574 metal-binding site 480224004575 Response regulator receiver domain; Region: Response_reg; pfam00072 480224004576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224004577 active site 480224004578 phosphorylation site [posttranslational modification] 480224004579 intermolecular recognition site; other site 480224004580 dimerization interface [polypeptide binding]; other site 480224004581 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 480224004582 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 480224004583 ATP binding site [chemical binding]; other site 480224004584 Mg2+ binding site [ion binding]; other site 480224004585 G-X-G motif; other site 480224004586 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 480224004587 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 480224004588 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 480224004589 anti sigma factor interaction site; other site 480224004590 regulatory phosphorylation site [posttranslational modification]; other site 480224004591 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 480224004592 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 480224004593 active site 480224004594 Substrate binding site; other site 480224004595 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 480224004596 putative trimer interface [polypeptide binding]; other site 480224004597 putative CoA binding site [chemical binding]; other site 480224004598 Bacterial sugar transferase; Region: Bac_transf; cl00939 480224004599 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 480224004600 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 480224004601 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 480224004602 anti sigma factor interaction site; other site 480224004603 regulatory phosphorylation site [posttranslational modification]; other site 480224004604 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 480224004605 anti sigma factor interaction site; other site 480224004606 regulatory phosphorylation site [posttranslational modification]; other site 480224004607 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 480224004608 Bacterial sugar transferase; Region: Bac_transf; pfam02397 480224004609 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 480224004610 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 480224004611 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 480224004612 trimer interface [polypeptide binding]; other site 480224004613 active site 480224004614 substrate binding site [chemical binding]; other site 480224004615 CoA binding site [chemical binding]; other site 480224004616 Chain length determinant protein; Region: Wzz; cl15801 480224004617 AAA domain; Region: AAA_31; pfam13614 480224004618 DDE superfamily endonuclease; Region: DDE_5; cl17874 480224004619 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 480224004620 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 480224004621 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 480224004622 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 480224004623 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 480224004624 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 480224004625 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 480224004626 DNA binding residues [nucleotide binding] 480224004627 Winged helix-turn helix; Region: HTH_29; pfam13551 480224004628 Helix-turn-helix domain; Region: HTH_28; pfam13518 480224004629 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 480224004630 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 480224004631 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 480224004632 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 480224004633 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 480224004634 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 480224004635 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 480224004636 HEPN domain; Region: HEPN; pfam05168 480224004637 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 480224004638 Bacterial sugar transferase; Region: Bac_transf; pfam02397 480224004639 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 480224004640 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 480224004641 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 480224004642 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224004643 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 480224004644 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844 480224004645 putative ADP-binding pocket [chemical binding]; other site 480224004646 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224004647 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 480224004648 O-Antigen ligase; Region: Wzy_C; pfam04932 480224004649 Methyltransferase domain; Region: Methyltransf_23; pfam13489 480224004650 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224004651 S-adenosylmethionine binding site [chemical binding]; other site 480224004652 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 480224004653 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 480224004654 Methyltransferase domain; Region: Methyltransf_31; pfam13847 480224004655 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224004656 S-adenosylmethionine binding site [chemical binding]; other site 480224004657 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224004658 TPR repeat; Region: TPR_11; pfam13414 480224004659 binding surface 480224004660 TPR motif; other site 480224004661 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 480224004662 Cytochrome P450; Region: p450; pfam00067 480224004663 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 480224004664 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 480224004665 active site 480224004666 substrate binding site [chemical binding]; other site 480224004667 metal binding site [ion binding]; metal-binding site 480224004668 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 480224004669 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 480224004670 metal binding site [ion binding]; metal-binding site 480224004671 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cl00425 480224004672 phosphate binding site [ion binding]; other site 480224004673 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 480224004674 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 480224004675 catalytic site [active] 480224004676 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224004677 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 480224004678 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 480224004679 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 480224004680 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 480224004681 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 480224004682 active site 480224004683 Ap6A binding site [chemical binding]; other site 480224004684 nudix motif; other site 480224004685 metal binding site [ion binding]; metal-binding site 480224004686 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 480224004687 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 480224004688 trigger factor; Region: tig; TIGR00115 480224004689 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 480224004690 Clp protease; Region: CLP_protease; pfam00574 480224004691 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 480224004692 oligomer interface [polypeptide binding]; other site 480224004693 active site residues [active] 480224004694 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 480224004695 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 480224004696 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 480224004697 Walker A motif; other site 480224004698 ATP binding site [chemical binding]; other site 480224004699 Walker B motif; other site 480224004700 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 480224004701 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 480224004702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224004703 active site 480224004704 phosphorylation site [posttranslational modification] 480224004705 intermolecular recognition site; other site 480224004706 dimerization interface [polypeptide binding]; other site 480224004707 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 480224004708 DNA binding site [nucleotide binding] 480224004709 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 480224004710 active site 480224004711 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 480224004712 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 480224004713 Mg++ binding site [ion binding]; other site 480224004714 putative catalytic motif [active] 480224004715 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 480224004716 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 480224004717 ligand binding site [chemical binding]; other site 480224004718 flexible hinge region; other site 480224004719 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 480224004720 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 480224004721 ligand binding site [chemical binding]; other site 480224004722 flexible hinge region; other site 480224004723 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 480224004724 4Fe-4S binding domain; Region: Fer4; pfam00037 480224004725 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 480224004726 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 480224004727 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 480224004728 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 480224004729 gamma-glutamyl kinase; Provisional; Region: PRK05429 480224004730 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 480224004731 nucleotide binding site [chemical binding]; other site 480224004732 homotetrameric interface [polypeptide binding]; other site 480224004733 putative phosphate binding site [ion binding]; other site 480224004734 putative allosteric binding site; other site 480224004735 PUA domain; Region: PUA; pfam01472 480224004736 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 480224004737 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 480224004738 HIGH motif; other site 480224004739 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 480224004740 active site 480224004741 KMSKS motif; other site 480224004742 ferredoxin-NADP+ reductase; Region: PLN02852 480224004743 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 480224004744 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 480224004745 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224004746 putative acyltransferase; Provisional; Region: PRK05790 480224004747 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 480224004748 dimer interface [polypeptide binding]; other site 480224004749 active site 480224004750 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 480224004751 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 480224004752 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 480224004753 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 480224004754 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 480224004755 beta-galactosidase; Region: BGL; TIGR03356 480224004756 Major Facilitator Superfamily; Region: MFS_1; pfam07690 480224004757 Putative zinc-finger; Region: zf-HC2; pfam13490 480224004758 Transcriptional regulator [Transcription]; Region: LytR; COG1316 480224004759 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 480224004760 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 480224004761 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 480224004762 Ferredoxin [Energy production and conversion]; Region: COG1146 480224004763 4Fe-4S binding domain; Region: Fer4; cl02805 480224004764 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 480224004765 Domain of unknown function (DUF814); Region: DUF814; pfam05670 480224004766 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 480224004767 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 480224004768 catalytic site [active] 480224004769 G-X2-G-X-G-K; other site 480224004770 Yqey-like protein; Region: YqeY; cl17540 480224004771 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 480224004772 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 480224004773 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 480224004774 Zn2+ binding site [ion binding]; other site 480224004775 Mg2+ binding site [ion binding]; other site 480224004776 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 480224004777 PAS domain S-box; Region: sensory_box; TIGR00229 480224004778 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224004779 putative active site [active] 480224004780 heme pocket [chemical binding]; other site 480224004781 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224004782 PAS fold; Region: PAS_3; pfam08447 480224004783 putative active site [active] 480224004784 heme pocket [chemical binding]; other site 480224004785 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 480224004786 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 480224004787 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 480224004788 metal binding site [ion binding]; metal-binding site 480224004789 dimer interface [polypeptide binding]; other site 480224004790 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 480224004791 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 480224004792 putative active site [active] 480224004793 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 480224004794 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 480224004795 MoxR-like ATPases [General function prediction only]; Region: COG0714 480224004796 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 480224004797 Walker A motif; other site 480224004798 ATP binding site [chemical binding]; other site 480224004799 Walker B motif; other site 480224004800 arginine finger; other site 480224004801 enoyl-CoA hydratase; Provisional; Region: PRK05995 480224004802 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 480224004803 substrate binding site [chemical binding]; other site 480224004804 oxyanion hole (OAH) forming residues; other site 480224004805 trimer interface [polypeptide binding]; other site 480224004806 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 480224004807 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 480224004808 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 480224004809 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 480224004810 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 480224004811 ligand binding site [chemical binding]; other site 480224004812 flexible hinge region; other site 480224004813 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 480224004814 putative switch regulator; other site 480224004815 non-specific DNA interactions [nucleotide binding]; other site 480224004816 DNA binding site [nucleotide binding] 480224004817 sequence specific DNA binding site [nucleotide binding]; other site 480224004818 putative cAMP binding site [chemical binding]; other site 480224004819 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 480224004820 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 480224004821 Multicopper oxidase; Region: Cu-oxidase; pfam00394 480224004822 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 480224004823 Ligand binding site; other site 480224004824 Putative Catalytic site; other site 480224004825 DXD motif; other site 480224004826 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 480224004827 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 480224004828 Uncharacterized conserved protein [Function unknown]; Region: COG2445 480224004829 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 480224004830 active site 480224004831 NTP binding site [chemical binding]; other site 480224004832 metal binding triad [ion binding]; metal-binding site 480224004833 antibiotic binding site [chemical binding]; other site 480224004834 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 480224004835 YbbR-like protein; Region: YbbR; pfam07949 480224004836 Uncharacterized conserved protein [Function unknown]; Region: COG1624 480224004837 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 480224004838 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224004839 binding surface 480224004840 TPR motif; other site 480224004841 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224004842 TPR motif; other site 480224004843 binding surface 480224004844 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224004845 binding surface 480224004846 TPR motif; other site 480224004847 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224004848 binding surface 480224004849 TPR motif; other site 480224004850 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224004851 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224004852 binding surface 480224004853 TPR repeat; Region: TPR_11; pfam13414 480224004854 TPR motif; other site 480224004855 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224004856 TPR motif; other site 480224004857 binding surface 480224004858 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224004859 binding surface 480224004860 TPR motif; other site 480224004861 ornithine carbamoyltransferase; Provisional; Region: PRK00779 480224004862 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 480224004863 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 480224004864 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 480224004865 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 480224004866 Walker A motif; other site 480224004867 ATP binding site [chemical binding]; other site 480224004868 Walker B motif; other site 480224004869 arginine finger; other site 480224004870 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 480224004871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 480224004872 Major Facilitator Superfamily; Region: MFS_1; pfam07690 480224004873 putative substrate translocation pore; other site 480224004874 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 480224004875 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 480224004876 dimer interface [polypeptide binding]; other site 480224004877 ssDNA binding site [nucleotide binding]; other site 480224004878 tetramer (dimer of dimers) interface [polypeptide binding]; other site 480224004879 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224004880 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224004881 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224004882 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224004883 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224004884 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 480224004885 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224004886 dimer interface [polypeptide binding]; other site 480224004887 phosphorylation site [posttranslational modification] 480224004888 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224004889 ATP binding site [chemical binding]; other site 480224004890 Mg2+ binding site [ion binding]; other site 480224004891 G-X-G motif; other site 480224004892 Response regulator receiver domain; Region: Response_reg; pfam00072 480224004893 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224004894 active site 480224004895 phosphorylation site [posttranslational modification] 480224004896 intermolecular recognition site; other site 480224004897 dimerization interface [polypeptide binding]; other site 480224004898 Bacterial SH3 domain; Region: SH3_3; pfam08239 480224004899 Bacterial SH3 domain; Region: SH3_3; pfam08239 480224004900 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 480224004901 NlpC/P60 family; Region: NLPC_P60; pfam00877 480224004902 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 480224004903 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 480224004904 Walker A/P-loop; other site 480224004905 ATP binding site [chemical binding]; other site 480224004906 Q-loop/lid; other site 480224004907 ABC transporter signature motif; other site 480224004908 Walker B; other site 480224004909 D-loop; other site 480224004910 H-loop/switch region; other site 480224004911 Integral membrane protein DUF95; Region: DUF95; pfam01944 480224004912 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 480224004913 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 480224004914 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 480224004915 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224004916 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 480224004917 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 480224004918 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 480224004919 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 480224004920 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 480224004921 active site 480224004922 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 480224004923 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 480224004924 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 480224004925 Peptidase M16C associated; Region: M16C_assoc; pfam08367 480224004926 amidase; Provisional; Region: PRK08137 480224004927 Amidase; Region: Amidase; cl11426 480224004928 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 480224004929 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 480224004930 active site 480224004931 tetramer interface [polypeptide binding]; other site 480224004932 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 480224004933 active site 480224004934 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 480224004935 active site 480224004936 catalytic triad [active] 480224004937 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 480224004938 Major Facilitator Superfamily; Region: MFS_1; pfam07690 480224004939 putative substrate translocation pore; other site 480224004940 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 480224004941 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 480224004942 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 480224004943 phosphopeptide binding site; other site 480224004944 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 480224004945 FOG: CBS domain [General function prediction only]; Region: COG0517 480224004946 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 480224004947 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 480224004948 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 480224004949 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 480224004950 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 480224004951 NAD(P) binding site [chemical binding]; other site 480224004952 active site 480224004953 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 480224004954 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 480224004955 active site 480224004956 Divergent AAA domain; Region: AAA_4; pfam04326 480224004957 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 480224004958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224004959 active site 480224004960 phosphorylation site [posttranslational modification] 480224004961 intermolecular recognition site; other site 480224004962 dimerization interface [polypeptide binding]; other site 480224004963 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 480224004964 DNA binding residues [nucleotide binding] 480224004965 dimerization interface [polypeptide binding]; other site 480224004966 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 480224004967 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 480224004968 Zn binding site [ion binding]; other site 480224004969 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 480224004970 Zn binding site [ion binding]; other site 480224004971 Peptidase family M48; Region: Peptidase_M48; cl12018 480224004972 Peptidase M30; Region: Peptidase_M30; pfam10460 480224004973 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 480224004974 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 480224004975 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 480224004976 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 480224004977 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 480224004978 Malic enzyme, N-terminal domain; Region: malic; pfam00390 480224004979 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 480224004980 putative NAD(P) binding site [chemical binding]; other site 480224004981 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 480224004982 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 480224004983 putative catalytic cysteine [active] 480224004984 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 480224004985 catalytic triad [active] 480224004986 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 480224004987 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224004988 S-adenosylmethionine binding site [chemical binding]; other site 480224004989 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 480224004990 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 480224004991 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 480224004992 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 480224004993 active site 480224004994 catalytic site [active] 480224004995 substrate binding site [chemical binding]; other site 480224004996 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 480224004997 DEAD_2; Region: DEAD_2; pfam06733 480224004998 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 480224004999 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 480224005000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224005001 active site 480224005002 phosphorylation site [posttranslational modification] 480224005003 intermolecular recognition site; other site 480224005004 dimerization interface [polypeptide binding]; other site 480224005005 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 480224005006 DNA binding residues [nucleotide binding] 480224005007 dimerization interface [polypeptide binding]; other site 480224005008 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 480224005009 active site 480224005010 dimer interface [polypeptide binding]; other site 480224005011 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 480224005012 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 480224005013 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 480224005014 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 480224005015 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 480224005016 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224005017 dimer interface [polypeptide binding]; other site 480224005018 conserved gate region; other site 480224005019 putative PBP binding loops; other site 480224005020 ABC-ATPase subunit interface; other site 480224005021 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 480224005022 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 480224005023 Walker A/P-loop; other site 480224005024 ATP binding site [chemical binding]; other site 480224005025 Q-loop/lid; other site 480224005026 ABC transporter signature motif; other site 480224005027 Walker B; other site 480224005028 D-loop; other site 480224005029 H-loop/switch region; other site 480224005030 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 480224005031 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 480224005032 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 480224005033 Walker A/P-loop; other site 480224005034 ATP binding site [chemical binding]; other site 480224005035 Q-loop/lid; other site 480224005036 ABC transporter signature motif; other site 480224005037 Walker B; other site 480224005038 D-loop; other site 480224005039 H-loop/switch region; other site 480224005040 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 480224005041 exonuclease subunit SbcD; Provisional; Region: PRK10966 480224005042 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 480224005043 active site 480224005044 metal binding site [ion binding]; metal-binding site 480224005045 DNA binding site [nucleotide binding] 480224005046 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 480224005047 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 480224005048 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 480224005049 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 480224005050 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 480224005051 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 480224005052 inhibitor-cofactor binding pocket; inhibition site 480224005053 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224005054 catalytic residue [active] 480224005055 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 480224005056 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 480224005057 NAD(P) binding site [chemical binding]; other site 480224005058 active site 480224005059 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 480224005060 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 480224005061 inhibitor-cofactor binding pocket; inhibition site 480224005062 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224005063 catalytic residue [active] 480224005064 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 480224005065 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 480224005066 active site 480224005067 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 480224005068 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 480224005069 NodB motif; other site 480224005070 active site 480224005071 catalytic site [active] 480224005072 metal binding site [ion binding]; metal-binding site 480224005073 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 480224005074 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 480224005075 active site 480224005076 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 480224005077 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 480224005078 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 480224005079 active site 480224005080 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 480224005081 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 480224005082 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 480224005083 Probable Catalytic site; other site 480224005084 metal-binding site 480224005085 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 480224005086 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 480224005087 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 480224005088 trimer interface [polypeptide binding]; other site 480224005089 active site 480224005090 substrate binding site [chemical binding]; other site 480224005091 CoA binding site [chemical binding]; other site 480224005092 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 480224005093 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 480224005094 active site 480224005095 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 480224005096 trimer interface [polypeptide binding]; other site 480224005097 active site 480224005098 substrate binding site [chemical binding]; other site 480224005099 CoA binding site [chemical binding]; other site 480224005100 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 480224005101 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224005102 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 480224005103 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 480224005104 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224005105 homodimer interface [polypeptide binding]; other site 480224005106 catalytic residue [active] 480224005107 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 480224005108 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 480224005109 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 480224005110 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 480224005111 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 480224005112 GAF domain; Region: GAF_2; pfam13185 480224005113 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224005114 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 480224005115 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 480224005116 metal binding site [ion binding]; metal-binding site 480224005117 active site 480224005118 I-site; other site 480224005119 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 480224005120 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 480224005121 catalytic core [active] 480224005122 conserved hypothetical protein; Region: TIGR03847 480224005123 conserved hypothetical protein; Region: TIGR03843 480224005124 PAS domain; Region: PAS; smart00091 480224005125 PAS fold; Region: PAS_7; pfam12860 480224005126 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 480224005127 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 480224005128 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 480224005129 Walker A/P-loop; other site 480224005130 ATP binding site [chemical binding]; other site 480224005131 Q-loop/lid; other site 480224005132 ABC transporter signature motif; other site 480224005133 Walker B; other site 480224005134 D-loop; other site 480224005135 H-loop/switch region; other site 480224005136 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 480224005137 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 480224005138 Walker A/P-loop; other site 480224005139 ATP binding site [chemical binding]; other site 480224005140 Q-loop/lid; other site 480224005141 ABC transporter signature motif; other site 480224005142 Walker B; other site 480224005143 D-loop; other site 480224005144 H-loop/switch region; other site 480224005145 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 480224005146 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 480224005147 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 480224005148 catalytic residue [active] 480224005149 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 480224005150 putative active site [active] 480224005151 catalytic residue [active] 480224005152 methionine sulfoxide reductase A; Provisional; Region: PRK14054 480224005153 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 480224005154 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 480224005155 active site 480224005156 metal binding site [ion binding]; metal-binding site 480224005157 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 480224005158 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 480224005159 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 480224005160 dimer interface [polypeptide binding]; other site 480224005161 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 480224005162 putative CheW interface [polypeptide binding]; other site 480224005163 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 480224005164 putative binding surface; other site 480224005165 active site 480224005166 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 480224005167 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224005168 ATP binding site [chemical binding]; other site 480224005169 Mg2+ binding site [ion binding]; other site 480224005170 G-X-G motif; other site 480224005171 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 480224005172 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 480224005173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224005174 active site 480224005175 phosphorylation site [posttranslational modification] 480224005176 intermolecular recognition site; other site 480224005177 dimerization interface [polypeptide binding]; other site 480224005178 Response regulator receiver domain; Region: Response_reg; pfam00072 480224005179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224005180 active site 480224005181 phosphorylation site [posttranslational modification] 480224005182 intermolecular recognition site; other site 480224005183 dimerization interface [polypeptide binding]; other site 480224005184 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 480224005185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224005186 active site 480224005187 phosphorylation site [posttranslational modification] 480224005188 intermolecular recognition site; other site 480224005189 dimerization interface [polypeptide binding]; other site 480224005190 CheB methylesterase; Region: CheB_methylest; pfam01339 480224005191 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 480224005192 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 480224005193 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224005194 TPR repeat; Region: TPR_11; pfam13414 480224005195 binding surface 480224005196 TPR motif; other site 480224005197 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 480224005198 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 480224005199 TPR repeat; Region: TPR_11; pfam13414 480224005200 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224005201 binding surface 480224005202 TPR motif; other site 480224005203 TPR repeat; Region: TPR_11; pfam13414 480224005204 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224005205 binding surface 480224005206 TPR motif; other site 480224005207 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 480224005208 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224005209 binding surface 480224005210 TPR motif; other site 480224005211 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224005212 binding surface 480224005213 TPR motif; other site 480224005214 TPR repeat; Region: TPR_11; pfam13414 480224005215 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224005216 binding surface 480224005217 Tetratricopeptide repeat; Region: TPR_16; pfam13432 480224005218 TPR motif; other site 480224005219 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 480224005220 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224005221 ATP binding site [chemical binding]; other site 480224005222 Mg2+ binding site [ion binding]; other site 480224005223 G-X-G motif; other site 480224005224 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 480224005225 anti sigma factor interaction site; other site 480224005226 regulatory phosphorylation site [posttranslational modification]; other site 480224005227 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 480224005228 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 480224005229 dimer interface [polypeptide binding]; other site 480224005230 NAD binding site [chemical binding]; other site 480224005231 substrate binding site [chemical binding]; other site 480224005232 tetramer (dimer of dimers) interface [polypeptide binding]; other site 480224005233 Response regulator receiver domain; Region: Response_reg; pfam00072 480224005234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224005235 active site 480224005236 phosphorylation site [posttranslational modification] 480224005237 intermolecular recognition site; other site 480224005238 dimerization interface [polypeptide binding]; other site 480224005239 Response regulator receiver domain; Region: Response_reg; pfam00072 480224005240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224005241 active site 480224005242 phosphorylation site [posttranslational modification] 480224005243 intermolecular recognition site; other site 480224005244 dimerization interface [polypeptide binding]; other site 480224005245 GAF domain; Region: GAF_3; pfam13492 480224005246 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 480224005247 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 480224005248 Zn2+ binding site [ion binding]; other site 480224005249 Mg2+ binding site [ion binding]; other site 480224005250 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 480224005251 Restriction endonuclease; Region: Mrr_cat; pfam04471 480224005252 Bacterial SH3 domain; Region: SH3_3; pfam08239 480224005253 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 480224005254 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 480224005255 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 480224005256 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 480224005257 Walker A/P-loop; other site 480224005258 ATP binding site [chemical binding]; other site 480224005259 Q-loop/lid; other site 480224005260 ABC transporter signature motif; other site 480224005261 Walker B; other site 480224005262 D-loop; other site 480224005263 H-loop/switch region; other site 480224005264 TOBE domain; Region: TOBE_2; pfam08402 480224005265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224005266 dimer interface [polypeptide binding]; other site 480224005267 conserved gate region; other site 480224005268 putative PBP binding loops; other site 480224005269 ABC-ATPase subunit interface; other site 480224005270 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 480224005271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224005272 dimer interface [polypeptide binding]; other site 480224005273 conserved gate region; other site 480224005274 putative PBP binding loops; other site 480224005275 ABC-ATPase subunit interface; other site 480224005276 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 480224005277 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 480224005278 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 480224005279 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 480224005280 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 480224005281 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 480224005282 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 480224005283 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 480224005284 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 480224005285 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 480224005286 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 480224005287 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 480224005288 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 480224005289 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 480224005290 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 480224005291 Domain of unknown function (DUF333); Region: DUF333; pfam03891 480224005292 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 480224005293 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 480224005294 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 480224005295 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 480224005296 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 480224005297 E3 interaction surface; other site 480224005298 lipoyl attachment site [posttranslational modification]; other site 480224005299 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 480224005300 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 480224005301 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 480224005302 alpha subunit interface [polypeptide binding]; other site 480224005303 TPP binding site [chemical binding]; other site 480224005304 heterodimer interface [polypeptide binding]; other site 480224005305 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 480224005306 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 480224005307 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 480224005308 tetramer interface [polypeptide binding]; other site 480224005309 TPP-binding site [chemical binding]; other site 480224005310 heterodimer interface [polypeptide binding]; other site 480224005311 phosphorylation loop region [posttranslational modification] 480224005312 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 480224005313 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 480224005314 active site 480224005315 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 480224005316 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 480224005317 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 480224005318 oligomer interface [polypeptide binding]; other site 480224005319 active site 480224005320 metal binding site [ion binding]; metal-binding site 480224005321 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 480224005322 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 480224005323 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 480224005324 NAD(P) binding site [chemical binding]; other site 480224005325 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 480224005326 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 480224005327 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 480224005328 ATP-binding site [chemical binding]; other site 480224005329 Sugar specificity; other site 480224005330 Pyrimidine base specificity; other site 480224005331 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 480224005332 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 480224005333 active site 480224005334 catalytic residues [active] 480224005335 putative acetyltransferase; Provisional; Region: PRK03624 480224005336 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 480224005337 Coenzyme A binding pocket [chemical binding]; other site 480224005338 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224005339 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 480224005340 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 480224005341 MarR family; Region: MarR; pfam01047 480224005342 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 480224005343 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 480224005344 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 480224005345 Walker A/P-loop; other site 480224005346 ATP binding site [chemical binding]; other site 480224005347 Q-loop/lid; other site 480224005348 ABC transporter signature motif; other site 480224005349 Walker B; other site 480224005350 D-loop; other site 480224005351 H-loop/switch region; other site 480224005352 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 480224005353 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 480224005354 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 480224005355 Walker A/P-loop; other site 480224005356 ATP binding site [chemical binding]; other site 480224005357 Q-loop/lid; other site 480224005358 ABC transporter signature motif; other site 480224005359 Walker B; other site 480224005360 D-loop; other site 480224005361 H-loop/switch region; other site 480224005362 Clostripain family; Region: Peptidase_C11; pfam03415 480224005363 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 480224005364 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 480224005365 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 480224005366 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 480224005367 metal binding site 2 [ion binding]; metal-binding site 480224005368 putative DNA binding helix; other site 480224005369 metal binding site 1 [ion binding]; metal-binding site 480224005370 dimer interface [polypeptide binding]; other site 480224005371 structural Zn2+ binding site [ion binding]; other site 480224005372 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 480224005373 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 480224005374 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 480224005375 Catalytic domain of Protein Kinases; Region: PKc; cd00180 480224005376 active site 480224005377 ATP binding site [chemical binding]; other site 480224005378 substrate binding site [chemical binding]; other site 480224005379 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 480224005380 Bacterial SH3 domain; Region: SH3_3; pfam08239 480224005381 4-aminobutyrate aminotransferase; Provisional; Region: PRK05769 480224005382 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 480224005383 inhibitor-cofactor binding pocket; inhibition site 480224005384 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224005385 catalytic residue [active] 480224005386 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 480224005387 Peptidase family M50; Region: Peptidase_M50; pfam02163 480224005388 active site 480224005389 putative substrate binding region [chemical binding]; other site 480224005390 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 480224005391 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 480224005392 ligand binding site [chemical binding]; other site 480224005393 flexible hinge region; other site 480224005394 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 480224005395 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 480224005396 ligand binding site [chemical binding]; other site 480224005397 flexible hinge region; other site 480224005398 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 480224005399 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 480224005400 substrate binding site [chemical binding]; other site 480224005401 dimer interface [polypeptide binding]; other site 480224005402 ATP binding site [chemical binding]; other site 480224005403 Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041 480224005404 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 480224005405 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 480224005406 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 480224005407 P loop; other site 480224005408 GTP binding site [chemical binding]; other site 480224005409 PGAP1-like protein; Region: PGAP1; pfam07819 480224005410 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 480224005411 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 480224005412 catalytic loop [active] 480224005413 iron binding site [ion binding]; other site 480224005414 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 480224005415 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 480224005416 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 480224005417 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 480224005418 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 480224005419 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 480224005420 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 480224005421 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 480224005422 Protein of unknown function (DUF512); Region: DUF512; pfam04459 480224005423 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224005424 GAF domain; Region: GAF_2; pfam13185 480224005425 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224005426 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 480224005427 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 480224005428 Zn2+ binding site [ion binding]; other site 480224005429 Mg2+ binding site [ion binding]; other site 480224005430 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 480224005431 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 480224005432 glutamine binding [chemical binding]; other site 480224005433 catalytic triad [active] 480224005434 short chain dehydrogenase; Provisional; Region: PRK06172 480224005435 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 480224005436 NAD(P) binding site [chemical binding]; other site 480224005437 active site 480224005438 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 480224005439 DNA binding site [nucleotide binding] 480224005440 active site 480224005441 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 480224005442 Major Facilitator Superfamily; Region: MFS_1; pfam07690 480224005443 putative substrate translocation pore; other site 480224005444 Partial alpha/beta-hydrolase lipase region; Region: Abhydro_lipase; pfam04083 480224005445 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 480224005446 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 480224005447 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 480224005448 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 480224005449 Ubiquitin-like proteins; Region: UBQ; cl00155 480224005450 hydrophobic patch; other site 480224005451 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 480224005452 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 480224005453 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 480224005454 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 480224005455 Walker A/P-loop; other site 480224005456 ATP binding site [chemical binding]; other site 480224005457 Q-loop/lid; other site 480224005458 ABC transporter signature motif; other site 480224005459 Walker B; other site 480224005460 D-loop; other site 480224005461 H-loop/switch region; other site 480224005462 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 480224005463 putative carbohydrate binding site [chemical binding]; other site 480224005464 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 480224005465 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224005466 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 480224005467 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 480224005468 Probable Catalytic site; other site 480224005469 metal-binding site 480224005470 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 480224005471 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 480224005472 Probable Catalytic site; other site 480224005473 metal-binding site 480224005474 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224005475 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 480224005476 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224005477 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 480224005478 Family description; Region: VCBS; pfam13517 480224005479 Family description; Region: VCBS; pfam13517 480224005480 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 480224005481 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 480224005482 NAD(P) binding site [chemical binding]; other site 480224005483 active site 480224005484 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224005485 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 480224005486 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 480224005487 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 480224005488 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 480224005489 catalytic residue [active] 480224005490 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 480224005491 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 480224005492 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 480224005493 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 480224005494 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 480224005495 active site 480224005496 dimer interface [polypeptide binding]; other site 480224005497 effector binding site; other site 480224005498 TSCPD domain; Region: TSCPD; pfam12637 480224005499 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 480224005500 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 480224005501 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 480224005502 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 480224005503 TrkA-N domain; Region: TrkA_N; pfam02254 480224005504 TrkA-N domain; Region: TrkA_N; pfam02254 480224005505 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 480224005506 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 480224005507 active site 480224005508 Membrane transport protein; Region: Mem_trans; cl09117 480224005509 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 480224005510 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 480224005511 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 480224005512 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 480224005513 active site 480224005514 Substrate binding site; other site 480224005515 Mg++ binding site; other site 480224005516 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 480224005517 putative trimer interface [polypeptide binding]; other site 480224005518 putative CoA binding site [chemical binding]; other site 480224005519 Domain of unknown function (DUF3524); Region: DUF3524; pfam12038 480224005520 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224005521 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 480224005522 LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cd08368 480224005523 Zn binding site [ion binding]; other site 480224005524 Predicted esterase [General function prediction only]; Region: COG0400 480224005525 putative hydrolase; Provisional; Region: PRK11460 480224005526 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 480224005527 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 480224005528 Transcriptional regulator [Transcription]; Region: LytR; COG1316 480224005529 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 480224005530 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 480224005531 Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like; Region: ALDH_AldH-CAJ73105; cd07131 480224005532 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 480224005533 NAD binding site [chemical binding]; other site 480224005534 catalytic residues [active] 480224005535 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 480224005536 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 480224005537 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 480224005538 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 480224005539 Cache domain; Region: Cache_1; pfam02743 480224005540 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 480224005541 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 480224005542 dimerization interface [polypeptide binding]; other site 480224005543 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224005544 dimer interface [polypeptide binding]; other site 480224005545 phosphorylation site [posttranslational modification] 480224005546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224005547 ATP binding site [chemical binding]; other site 480224005548 Mg2+ binding site [ion binding]; other site 480224005549 G-X-G motif; other site 480224005550 Response regulator receiver domain; Region: Response_reg; pfam00072 480224005551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224005552 active site 480224005553 phosphorylation site [posttranslational modification] 480224005554 intermolecular recognition site; other site 480224005555 dimerization interface [polypeptide binding]; other site 480224005556 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 480224005557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224005558 active site 480224005559 phosphorylation site [posttranslational modification] 480224005560 intermolecular recognition site; other site 480224005561 dimerization interface [polypeptide binding]; other site 480224005562 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 480224005563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224005564 active site 480224005565 phosphorylation site [posttranslational modification] 480224005566 intermolecular recognition site; other site 480224005567 dimerization interface [polypeptide binding]; other site 480224005568 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 480224005569 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 480224005570 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 480224005571 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 480224005572 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 480224005573 ATP-grasp domain; Region: ATP-grasp_4; cl17255 480224005574 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 480224005575 IMP binding site; other site 480224005576 dimer interface [polypeptide binding]; other site 480224005577 interdomain contacts; other site 480224005578 partial ornithine binding site; other site 480224005579 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 480224005580 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 480224005581 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 480224005582 Walker A/P-loop; other site 480224005583 ATP binding site [chemical binding]; other site 480224005584 Q-loop/lid; other site 480224005585 ABC transporter signature motif; other site 480224005586 Walker B; other site 480224005587 D-loop; other site 480224005588 H-loop/switch region; other site 480224005589 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 480224005590 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 480224005591 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 480224005592 Walker A/P-loop; other site 480224005593 ATP binding site [chemical binding]; other site 480224005594 Q-loop/lid; other site 480224005595 ABC transporter signature motif; other site 480224005596 Walker B; other site 480224005597 D-loop; other site 480224005598 H-loop/switch region; other site 480224005599 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 480224005600 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 480224005601 phosphopeptide binding site; other site 480224005602 Clostripain family; Region: Peptidase_C11; pfam03415 480224005603 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224005604 dimer interface [polypeptide binding]; other site 480224005605 phosphorylation site [posttranslational modification] 480224005606 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224005607 ATP binding site [chemical binding]; other site 480224005608 Mg2+ binding site [ion binding]; other site 480224005609 G-X-G motif; other site 480224005610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 480224005611 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 480224005612 NADH dehydrogenase subunit L; Provisional; Region: PRK08168 480224005613 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 480224005614 Transcriptional regulator [Transcription]; Region: LysR; COG0583 480224005615 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 480224005616 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 480224005617 dimerization interface [polypeptide binding]; other site 480224005618 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 480224005619 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 480224005620 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 480224005621 Domain of unknown function (DUF897); Region: DUF897; pfam05982 480224005622 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 480224005623 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 480224005624 phosphate binding site [ion binding]; other site 480224005625 putative substrate binding pocket [chemical binding]; other site 480224005626 dimer interface [polypeptide binding]; other site 480224005627 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 480224005628 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 480224005629 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224005630 TPR repeat; Region: TPR_11; pfam13414 480224005631 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224005632 binding surface 480224005633 TPR motif; other site 480224005634 TPR repeat; Region: TPR_11; pfam13414 480224005635 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224005636 binding surface 480224005637 TPR motif; other site 480224005638 TPR repeat; Region: TPR_11; pfam13414 480224005639 TPR repeat; Region: TPR_11; pfam13414 480224005640 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224005641 TPR motif; other site 480224005642 binding surface 480224005643 TPR repeat; Region: TPR_11; pfam13414 480224005644 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224005645 binding surface 480224005646 TPR motif; other site 480224005647 TPR repeat; Region: TPR_11; pfam13414 480224005648 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224005649 binding surface 480224005650 TPR repeat; Region: TPR_11; pfam13414 480224005651 TPR motif; other site 480224005652 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 480224005653 putative MPT binding site; other site 480224005654 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 480224005655 prolyl-tRNA synthetase; Provisional; Region: PRK09194 480224005656 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 480224005657 motif 1; other site 480224005658 dimer interface [polypeptide binding]; other site 480224005659 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 480224005660 putative deacylase active site [active] 480224005661 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 480224005662 anticodon binding site; other site 480224005663 Protein of unknown function DUF72; Region: DUF72; pfam01904 480224005664 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 480224005665 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 480224005666 Glutamate binding site [chemical binding]; other site 480224005667 homodimer interface [polypeptide binding]; other site 480224005668 NAD binding site [chemical binding]; other site 480224005669 catalytic residues [active] 480224005670 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 480224005671 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 480224005672 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 480224005673 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 480224005674 alanine racemase; Reviewed; Region: alr; PRK00053 480224005675 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 480224005676 active site 480224005677 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 480224005678 dimer interface [polypeptide binding]; other site 480224005679 substrate binding site [chemical binding]; other site 480224005680 catalytic residues [active] 480224005681 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 480224005682 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 480224005683 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 480224005684 active site 480224005685 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 480224005686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224005687 active site 480224005688 phosphorylation site [posttranslational modification] 480224005689 intermolecular recognition site; other site 480224005690 dimerization interface [polypeptide binding]; other site 480224005691 ANTAR domain; Region: ANTAR; pfam03861 480224005692 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 480224005693 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 480224005694 active site 480224005695 Substrate binding site; other site 480224005696 Mg++ binding site; other site 480224005697 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 480224005698 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 480224005699 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 480224005700 Walker A/P-loop; other site 480224005701 ATP binding site [chemical binding]; other site 480224005702 Q-loop/lid; other site 480224005703 ABC transporter signature motif; other site 480224005704 Walker B; other site 480224005705 D-loop; other site 480224005706 H-loop/switch region; other site 480224005707 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 480224005708 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224005709 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 480224005710 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 480224005711 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 480224005712 catalytic residue [active] 480224005713 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 480224005714 C-terminal peptidase (prc); Region: prc; TIGR00225 480224005715 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 480224005716 protein binding site [polypeptide binding]; other site 480224005717 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 480224005718 Domain interface; other site 480224005719 Peptide binding site; other site 480224005720 Active site tetrad [active] 480224005721 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 480224005722 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 480224005723 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 480224005724 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 480224005725 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 480224005726 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 480224005727 MarR family; Region: MarR_2; cl17246 480224005728 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 480224005729 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 480224005730 active site 480224005731 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 480224005732 4Fe-4S binding domain; Region: Fer4_2; pfam12797 480224005733 Cysteine-rich domain; Region: CCG; pfam02754 480224005734 Cysteine-rich domain; Region: CCG; pfam02754 480224005735 HsdM N-terminal domain; Region: HsdM_N; pfam12161 480224005736 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 480224005737 Methyltransferase domain; Region: Methyltransf_26; pfam13659 480224005738 Domain of unknown function (DUF955); Region: DUF955; cl01076 480224005739 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 480224005740 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 480224005741 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 480224005742 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 480224005743 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 480224005744 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 480224005745 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 480224005746 ATP binding site [chemical binding]; other site 480224005747 putative Mg++ binding site [ion binding]; other site 480224005748 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 480224005749 FOG: CBS domain [General function prediction only]; Region: COG0517 480224005750 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 480224005751 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 480224005752 putative active site [active] 480224005753 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 480224005754 lycopene cyclase; Region: lycopene_cycl; TIGR01789 480224005755 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 480224005756 Uncharacterized conserved protein [Function unknown]; Region: COG2353 480224005757 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 480224005758 catalytic residues [active] 480224005759 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 480224005760 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 480224005761 catalytic residues [active] 480224005762 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 480224005763 ABC1 family; Region: ABC1; cl17513 480224005764 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 480224005765 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 480224005766 TPP-binding site [chemical binding]; other site 480224005767 dimer interface [polypeptide binding]; other site 480224005768 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 480224005769 PYR/PP interface [polypeptide binding]; other site 480224005770 dimer interface [polypeptide binding]; other site 480224005771 TPP binding site [chemical binding]; other site 480224005772 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 480224005773 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 480224005774 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 480224005775 substrate binding site [chemical binding]; other site 480224005776 glutamase interaction surface [polypeptide binding]; other site 480224005777 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 480224005778 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224005779 GAF domain; Region: GAF_3; pfam13492 480224005780 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 480224005781 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224005782 dimer interface [polypeptide binding]; other site 480224005783 phosphorylation site [posttranslational modification] 480224005784 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224005785 ATP binding site [chemical binding]; other site 480224005786 Mg2+ binding site [ion binding]; other site 480224005787 G-X-G motif; other site 480224005788 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 480224005789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224005790 active site 480224005791 phosphorylation site [posttranslational modification] 480224005792 intermolecular recognition site; other site 480224005793 dimerization interface [polypeptide binding]; other site 480224005794 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 480224005795 DNA binding site [nucleotide binding] 480224005796 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 480224005797 Part of AAA domain; Region: AAA_19; pfam13245 480224005798 Family description; Region: UvrD_C_2; pfam13538 480224005799 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 480224005800 Catalytic domain of Protein Kinases; Region: PKc; cd00180 480224005801 active site 480224005802 ATP binding site [chemical binding]; other site 480224005803 substrate binding site [chemical binding]; other site 480224005804 activation loop (A-loop); other site 480224005805 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 480224005806 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 480224005807 Zn binding sites [ion binding]; other site 480224005808 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 480224005809 C-terminal peptidase (prc); Region: prc; TIGR00225 480224005810 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 480224005811 protein binding site [polypeptide binding]; other site 480224005812 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 480224005813 Catalytic dyad [active] 480224005814 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 480224005815 RNA methyltransferase, RsmE family; Region: TIGR00046 480224005816 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 480224005817 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 480224005818 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 480224005819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 480224005820 S-adenosylmethionine binding site [chemical binding]; other site 480224005821 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 480224005822 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 480224005823 active site 480224005824 HIGH motif; other site 480224005825 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 480224005826 KMSKS motif; other site 480224005827 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 480224005828 tRNA binding surface [nucleotide binding]; other site 480224005829 anticodon binding site; other site 480224005830 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 480224005831 serine O-acetyltransferase; Region: cysE; TIGR01172 480224005832 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 480224005833 trimer interface [polypeptide binding]; other site 480224005834 active site 480224005835 substrate binding site [chemical binding]; other site 480224005836 CoA binding site [chemical binding]; other site 480224005837 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 480224005838 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 480224005839 DNA-binding site [nucleotide binding]; DNA binding site 480224005840 RNA-binding motif; other site 480224005841 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 480224005842 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 480224005843 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 480224005844 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 480224005845 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 480224005846 active site 480224005847 putative substrate binding pocket [chemical binding]; other site 480224005848 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 480224005849 Mrr N-terminal domain; Region: Mrr_N; pfam14338 480224005850 Restriction endonuclease; Region: Mrr_cat; pfam04471 480224005851 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 480224005852 Helix-turn-helix domain; Region: HTH_25; pfam13413 480224005853 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 480224005854 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 480224005855 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 480224005856 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 480224005857 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 480224005858 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 480224005859 FeS/SAM binding site; other site 480224005860 Penicillinase repressor; Region: Pencillinase_R; pfam03965 480224005861 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 480224005862 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 480224005863 substrate binding pocket [chemical binding]; other site 480224005864 chain length determination region; other site 480224005865 substrate-Mg2+ binding site; other site 480224005866 catalytic residues [active] 480224005867 aspartate-rich region 1; other site 480224005868 active site lid residues [active] 480224005869 aspartate-rich region 2; other site 480224005870 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 480224005871 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 480224005872 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 480224005873 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 480224005874 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 480224005875 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 480224005876 putative active site [active] 480224005877 Zn binding site [ion binding]; other site 480224005878 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 480224005879 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 480224005880 putative anti-sigmaE protein; Provisional; Region: PRK13920 480224005881 Anti-sigma-K factor rskA; Region: RskA; pfam10099 480224005882 Response regulator receiver domain; Region: Response_reg; pfam00072 480224005883 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224005884 active site 480224005885 phosphorylation site [posttranslational modification] 480224005886 intermolecular recognition site; other site 480224005887 dimerization interface [polypeptide binding]; other site 480224005888 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224005889 GAF domain; Region: GAF; pfam01590 480224005890 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224005891 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224005892 GAF domain; Region: GAF_3; pfam13492 480224005893 GAF domain; Region: GAF_2; pfam13185 480224005894 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 480224005895 cyclase homology domain; Region: CHD; cd07302 480224005896 nucleotidyl binding site; other site 480224005897 metal binding site [ion binding]; metal-binding site 480224005898 dimer interface [polypeptide binding]; other site 480224005899 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 480224005900 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 480224005901 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 480224005902 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 480224005903 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 480224005904 N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510 480224005905 amidase catalytic site [active] 480224005906 Zn binding residues [ion binding]; other site 480224005907 substrate binding site [chemical binding]; other site 480224005908 MoxR-like ATPases [General function prediction only]; Region: COG0714 480224005909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 480224005910 Walker A motif; other site 480224005911 ATP binding site [chemical binding]; other site 480224005912 Walker B motif; other site 480224005913 arginine finger; other site 480224005914 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 480224005915 DNA photolyase; Region: DNA_photolyase; pfam00875 480224005916 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 480224005917 classical (c) SDRs; Region: SDR_c; cd05233 480224005918 NAD(P) binding site [chemical binding]; other site 480224005919 active site 480224005920 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 480224005921 MoaE interaction surface [polypeptide binding]; other site 480224005922 MoeB interaction surface [polypeptide binding]; other site 480224005923 thiocarboxylated glycine; other site 480224005924 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 480224005925 MoaE homodimer interface [polypeptide binding]; other site 480224005926 MoaD interaction [polypeptide binding]; other site 480224005927 active site residues [active] 480224005928 Response regulator receiver domain; Region: Response_reg; pfam00072 480224005929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224005930 active site 480224005931 phosphorylation site [posttranslational modification] 480224005932 intermolecular recognition site; other site 480224005933 dimerization interface [polypeptide binding]; other site 480224005934 Predicted ATPase [General function prediction only]; Region: COG4637 480224005935 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 480224005936 Walker A/P-loop; other site 480224005937 ATP binding site [chemical binding]; other site 480224005938 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 480224005939 ABC transporter signature motif; other site 480224005940 Walker B; other site 480224005941 D-loop; other site 480224005942 H-loop/switch region; other site 480224005943 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 480224005944 Zn2+ binding site [ion binding]; other site 480224005945 Mg2+ binding site [ion binding]; other site 480224005946 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 480224005947 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 480224005948 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 480224005949 catalytic residue [active] 480224005950 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224005951 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 480224005952 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 480224005953 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 480224005954 catalytic loop [active] 480224005955 iron binding site [ion binding]; other site 480224005956 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 480224005957 L-aspartate oxidase; Provisional; Region: PRK06175 480224005958 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 480224005959 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 480224005960 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 480224005961 putative Iron-sulfur protein interface [polypeptide binding]; other site 480224005962 proximal heme binding site [chemical binding]; other site 480224005963 distal heme binding site [chemical binding]; other site 480224005964 putative dimer interface [polypeptide binding]; other site 480224005965 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 480224005966 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 480224005967 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 480224005968 Peptidase family M23; Region: Peptidase_M23; pfam01551 480224005969 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224005970 TPR motif; other site 480224005971 TPR repeat; Region: TPR_11; pfam13414 480224005972 binding surface 480224005973 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 480224005974 binding surface 480224005975 TPR motif; other site 480224005976 acyl-CoA synthetase; Validated; Region: PRK08162 480224005977 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 480224005978 acyl-activating enzyme (AAE) consensus motif; other site 480224005979 putative active site [active] 480224005980 AMP binding site [chemical binding]; other site 480224005981 putative CoA binding site [chemical binding]; other site 480224005982 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 480224005983 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 480224005984 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 480224005985 active site 480224005986 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 480224005987 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 480224005988 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 480224005989 dihydroorotase; Validated; Region: pyrC; PRK09357 480224005990 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 480224005991 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 480224005992 active site 480224005993 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 480224005994 Pleckstrin homology-like domain; Region: PH-like; cl17171 480224005995 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 480224005996 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 480224005997 active site 480224005998 Zn binding site [ion binding]; other site 480224005999 hypothetical protein; Provisional; Region: PRK08912 480224006000 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 480224006001 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224006002 homodimer interface [polypeptide binding]; other site 480224006003 catalytic residue [active] 480224006004 putative alpha-glucosidase; Provisional; Region: PRK10658 480224006005 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 480224006006 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 480224006007 trimer interface [polypeptide binding]; other site 480224006008 active site 480224006009 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 480224006010 catalytic site [active] 480224006011 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl17552 480224006012 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 480224006013 active site 480224006014 NTP binding site [chemical binding]; other site 480224006015 metal binding triad [ion binding]; metal-binding site 480224006016 antibiotic binding site [chemical binding]; other site 480224006017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 480224006018 AAA domain; Region: AAA_23; pfam13476 480224006019 AAA domain; Region: AAA_21; pfam13304 480224006020 Walker A/P-loop; other site 480224006021 ATP binding site [chemical binding]; other site 480224006022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 480224006023 ABC transporter signature motif; other site 480224006024 Walker B; other site 480224006025 D-loop; other site 480224006026 H-loop/switch region; other site 480224006027 Transglycosylase; Region: Transgly; pfam00912 480224006028 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 480224006029 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 480224006030 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 480224006031 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 480224006032 CoA-binding site [chemical binding]; other site 480224006033 ATP-binding [chemical binding]; other site 480224006034 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 480224006035 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 480224006036 active site 480224006037 putative substrate binding pocket [chemical binding]; other site 480224006038 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 480224006039 putative active site; other site 480224006040 putative metal binding residues [ion binding]; other site 480224006041 signature motif; other site 480224006042 putative triphosphate binding site [ion binding]; other site 480224006043 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 480224006044 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 480224006045 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 480224006046 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 480224006047 hinge; other site 480224006048 active site 480224006049 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 480224006050 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 480224006051 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 480224006052 putative active site [active] 480224006053 catalytic triad [active] 480224006054 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 480224006055 PA/protease or protease-like domain interface [polypeptide binding]; other site 480224006056 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 480224006057 hypothetical protein; Validated; Region: PRK07682 480224006058 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 480224006059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224006060 homodimer interface [polypeptide binding]; other site 480224006061 catalytic residue [active] 480224006062 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 480224006063 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 480224006064 DNA binding residues [nucleotide binding] 480224006065 dimerization interface [polypeptide binding]; other site 480224006066 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 480224006067 Kelch domain; Region: Kelch; smart00612 480224006068 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 480224006069 Kelch domain; Region: Kelch; smart00612 480224006070 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 480224006071 Kelch motif; Region: Kelch_1; pfam01344 480224006072 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 480224006073 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224006074 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224006075 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 480224006076 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 480224006077 homoserine dehydrogenase; Provisional; Region: PRK06270 480224006078 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 480224006079 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 480224006080 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 480224006081 replicative DNA helicase; Provisional; Region: PRK05973 480224006082 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 480224006083 DNA binding residues [nucleotide binding] 480224006084 dimerization interface [polypeptide binding]; other site 480224006085 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 480224006086 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 480224006087 putative ligand binding site [chemical binding]; other site 480224006088 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 480224006089 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 480224006090 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 480224006091 TM-ABC transporter signature motif; other site 480224006092 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 480224006093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224006094 active site 480224006095 phosphorylation site [posttranslational modification] 480224006096 intermolecular recognition site; other site 480224006097 dimerization interface [polypeptide binding]; other site 480224006098 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 480224006099 dimerization interface [polypeptide binding]; other site 480224006100 DNA binding residues [nucleotide binding] 480224006101 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 480224006102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224006103 active site 480224006104 phosphorylation site [posttranslational modification] 480224006105 intermolecular recognition site; other site 480224006106 dimerization interface [polypeptide binding]; other site 480224006107 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 480224006108 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 480224006109 Walker A/P-loop; other site 480224006110 ATP binding site [chemical binding]; other site 480224006111 Q-loop/lid; other site 480224006112 ABC transporter signature motif; other site 480224006113 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 480224006114 Walker B; other site 480224006115 D-loop; other site 480224006116 H-loop/switch region; other site 480224006117 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 480224006118 DEAD-like helicases superfamily; Region: DEXDc; smart00487 480224006119 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 480224006120 ATP binding site [chemical binding]; other site 480224006121 putative Mg++ binding site [ion binding]; other site 480224006122 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 480224006123 ATP-binding site [chemical binding]; other site 480224006124 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 480224006125 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 480224006126 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 480224006127 dimer interface [polypeptide binding]; other site 480224006128 active site 480224006129 histidinol-phosphate aminotransferase; Provisional; Region: PLN03026 480224006130 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 480224006131 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224006132 homodimer interface [polypeptide binding]; other site 480224006133 catalytic residue [active] 480224006134 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 480224006135 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 480224006136 active site 480224006137 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 480224006138 putative metal binding site [ion binding]; other site 480224006139 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 480224006140 putative active site pocket [active] 480224006141 4-fold oligomerization interface [polypeptide binding]; other site 480224006142 metal binding residues [ion binding]; metal-binding site 480224006143 3-fold/trimer interface [polypeptide binding]; other site 480224006144 Protease prsW family; Region: PrsW-protease; pfam13367 480224006145 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 480224006146 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 480224006147 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 480224006148 acetylornithine aminotransferase; Provisional; Region: PRK02627 480224006149 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 480224006150 inhibitor-cofactor binding pocket; inhibition site 480224006151 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224006152 catalytic residue [active] 480224006153 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 480224006154 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 480224006155 GDP-binding site [chemical binding]; other site 480224006156 ACT binding site; other site 480224006157 IMP binding site; other site 480224006158 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 480224006159 active site 480224006160 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 480224006161 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 480224006162 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 480224006163 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 480224006164 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 480224006165 NAD(P) binding site [chemical binding]; other site 480224006166 shikimate binding site; other site 480224006167 YceG-like family; Region: YceG; pfam02618 480224006168 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 480224006169 dimerization interface [polypeptide binding]; other site 480224006170 threonine synthase; Validated; Region: PRK06260 480224006171 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 480224006172 homodimer interface [polypeptide binding]; other site 480224006173 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224006174 catalytic residue [active] 480224006175 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 480224006176 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 480224006177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224006178 S-adenosylmethionine binding site [chemical binding]; other site 480224006179 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 480224006180 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 480224006181 EamA-like transporter family; Region: EamA; pfam00892 480224006182 Hpt domain; Region: Hpt; pfam01627 480224006183 putative binding surface; other site 480224006184 active site 480224006185 Response regulator receiver domain; Region: Response_reg; pfam00072 480224006186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224006187 active site 480224006188 phosphorylation site [posttranslational modification] 480224006189 intermolecular recognition site; other site 480224006190 dimerization interface [polypeptide binding]; other site 480224006191 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 480224006192 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 480224006193 metal binding site [ion binding]; metal-binding site 480224006194 active site 480224006195 I-site; other site 480224006196 Response regulator receiver domain; Region: Response_reg; pfam00072 480224006197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224006198 active site 480224006199 phosphorylation site [posttranslational modification] 480224006200 intermolecular recognition site; other site 480224006201 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 480224006202 dimerization interface [polypeptide binding]; other site 480224006203 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 480224006204 Bacterial cellulose synthase subunit; Region: BcsB; pfam03170 480224006205 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 480224006206 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 480224006207 DXD motif; other site 480224006208 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 480224006209 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 480224006210 anti sigma factor interaction site; other site 480224006211 regulatory phosphorylation site [posttranslational modification]; other site 480224006212 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 480224006213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 480224006214 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 480224006215 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 480224006216 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 480224006217 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 480224006218 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 480224006219 putative active site [active] 480224006220 CpXC protein; Region: CpXC; pfam14353 480224006221 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224006222 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 480224006223 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 480224006224 NADP binding site [chemical binding]; other site 480224006225 dimer interface [polypeptide binding]; other site 480224006226 Aspartokinases [Amino acid transport and metabolism]; Region: LysC; COG0527 480224006227 AAK_AK-LysC-like: Amino Acid Kinase Superfamily (AAK), AK-LysC-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive AK isoenzyme found in higher plants. The lysine-sensitive AK isoenzyme is a monofunctional...; Region: AAK_AK-LysC-like; cd04244 480224006228 putative catalytic residues [active] 480224006229 putative nucleotide binding site [chemical binding]; other site 480224006230 aspartate binding site [chemical binding]; other site 480224006231 dimer interface [polypeptide binding]; other site 480224006232 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 480224006233 dimer interface [polypeptide binding]; other site 480224006234 putative threonine allosteric regulatory site; other site 480224006235 ACT domains of a monofunctional aspartokinase found mostly in Archaea species (ACT_AK-Arch_2); Region: ACT_AK-Arch_2; cd04924 480224006236 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 480224006237 ADP-ribose binding site [chemical binding]; other site 480224006238 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 480224006239 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 480224006240 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 480224006241 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 480224006242 inhibitor site; inhibition site 480224006243 active site 480224006244 dimer interface [polypeptide binding]; other site 480224006245 catalytic residue [active] 480224006246 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 480224006247 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 480224006248 substrate binding site; other site 480224006249 metal-binding site 480224006250 Oligomer interface; other site 480224006251 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 480224006252 Predicted methyltransferases [General function prediction only]; Region: COG0313 480224006253 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 480224006254 putative SAM binding site [chemical binding]; other site 480224006255 putative homodimer interface [polypeptide binding]; other site 480224006256 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 480224006257 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 480224006258 NADP-binding site; other site 480224006259 homotetramer interface [polypeptide binding]; other site 480224006260 substrate binding site [chemical binding]; other site 480224006261 homodimer interface [polypeptide binding]; other site 480224006262 active site 480224006263 FOG: CBS domain [General function prediction only]; Region: COG0517 480224006264 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 480224006265 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 480224006266 iron binding site [ion binding]; other site 480224006267 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 480224006268 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 480224006269 tetramer interface [polypeptide binding]; other site 480224006270 TPP-binding site [chemical binding]; other site 480224006271 heterodimer interface [polypeptide binding]; other site 480224006272 phosphorylation loop region [posttranslational modification] 480224006273 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 480224006274 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 480224006275 alpha subunit interface [polypeptide binding]; other site 480224006276 TPP binding site [chemical binding]; other site 480224006277 heterodimer interface [polypeptide binding]; other site 480224006278 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 480224006279 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 480224006280 E3 interaction surface; other site 480224006281 lipoyl attachment site [posttranslational modification]; other site 480224006282 e3 binding domain; Region: E3_binding; pfam02817 480224006283 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 480224006284 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 480224006285 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 480224006286 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 480224006287 active site residue [active] 480224006288 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 480224006289 active site residue [active] 480224006290 proton-translocating NADH-quinone oxidoreductase, chain N; Region: NDH_I_N; TIGR01770 480224006291 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 480224006292 NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; Region: NuoM; COG1008 480224006293 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 480224006294 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 480224006295 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 480224006296 proton-translocating NADH-quinone oxidoreductase, chain L; Region: NDH_I_L; TIGR01974 480224006297 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 480224006298 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 480224006299 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 480224006300 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 480224006301 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00057 480224006302 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 480224006303 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 480224006304 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 480224006305 4Fe-4S binding domain; Region: Fer4; pfam00037 480224006306 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 480224006307 NADH dehydrogenase subunit D; Validated; Region: PRK06075 480224006308 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 480224006309 NADH dehydrogenase subunit B; Provisional; Region: PRK14819 480224006310 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 480224006311 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 480224006312 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 480224006313 phosphopeptide binding site; other site 480224006314 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 480224006315 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 480224006316 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 480224006317 phosphopeptide binding site; other site 480224006318 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 480224006319 Glycoprotease family; Region: Peptidase_M22; pfam00814 480224006320 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 480224006321 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 480224006322 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 480224006323 intersubunit interface [polypeptide binding]; other site 480224006324 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 480224006325 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 480224006326 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 480224006327 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 480224006328 ABC-ATPase subunit interface; other site 480224006329 dimer interface [polypeptide binding]; other site 480224006330 putative PBP binding regions; other site 480224006331 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; pfam09587 480224006332 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 480224006333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224006334 active site 480224006335 phosphorylation site [posttranslational modification] 480224006336 intermolecular recognition site; other site 480224006337 dimerization interface [polypeptide binding]; other site 480224006338 ANTAR domain; Region: ANTAR; pfam03861 480224006339 TMAO/DMSO reductase; Reviewed; Region: PRK05363 480224006340 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 480224006341 Moco binding site; other site 480224006342 metal coordination site [ion binding]; other site 480224006343 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 480224006344 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 480224006345 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224006346 active site 480224006347 phosphorylation site [posttranslational modification] 480224006348 intermolecular recognition site; other site 480224006349 dimerization interface [polypeptide binding]; other site 480224006350 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 480224006351 DNA binding site [nucleotide binding] 480224006352 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 480224006353 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 480224006354 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 480224006355 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 480224006356 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 480224006357 catalytic triad [active] 480224006358 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 480224006359 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 480224006360 active site 480224006361 substrate binding site [chemical binding]; other site 480224006362 cosubstrate binding site; other site 480224006363 catalytic site [active] 480224006364 oxidative damage protection protein; Provisional; Region: PRK05408 480224006365 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 480224006366 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 480224006367 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 480224006368 FeS/SAM binding site; other site 480224006369 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 480224006370 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 480224006371 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 480224006372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 480224006373 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 480224006374 Uncharacterized conserved protein [Function unknown]; Region: COG2308 480224006375 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 480224006376 Fatty acid desaturase; Region: FA_desaturase; pfam00487 480224006377 Di-iron ligands [ion binding]; other site 480224006378 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 480224006379 C-terminal peptidase (prc); Region: prc; TIGR00225 480224006380 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 480224006381 protein binding site [polypeptide binding]; other site 480224006382 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 480224006383 Catalytic dyad [active] 480224006384 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 480224006385 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 480224006386 oligomer interface [polypeptide binding]; other site 480224006387 active site 480224006388 metal binding site [ion binding]; metal-binding site 480224006389 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 480224006390 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 480224006391 active site 480224006392 NTP binding site [chemical binding]; other site 480224006393 metal binding triad [ion binding]; metal-binding site 480224006394 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 480224006395 Lamin Tail Domain; Region: LTD; pfam00932 480224006396 CAAX protease self-immunity; Region: Abi; pfam02517 480224006397 beta-phosphoglucomutase; Region: bPGM; TIGR01990 480224006398 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 480224006399 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 480224006400 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 480224006401 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 480224006402 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 480224006403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224006404 dimer interface [polypeptide binding]; other site 480224006405 conserved gate region; other site 480224006406 putative PBP binding loops; other site 480224006407 ABC-ATPase subunit interface; other site 480224006408 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224006409 dimer interface [polypeptide binding]; other site 480224006410 conserved gate region; other site 480224006411 putative PBP binding loops; other site 480224006412 ABC-ATPase subunit interface; other site 480224006413 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 480224006414 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 480224006415 Transcriptional regulators [Transcription]; Region: PurR; COG1609 480224006416 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 480224006417 DNA binding site [nucleotide binding] 480224006418 domain linker motif; other site 480224006419 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 480224006420 ligand binding site [chemical binding]; other site 480224006421 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 480224006422 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 480224006423 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 480224006424 active site 480224006425 HIGH motif; other site 480224006426 KMSK motif region; other site 480224006427 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 480224006428 tRNA binding surface [nucleotide binding]; other site 480224006429 anticodon binding site; other site 480224006430 Protein of unknown function DUF262; Region: DUF262; pfam03235 480224006431 Uncharacterized conserved protein [Function unknown]; Region: COG1479 480224006432 Protein of unknown function DUF262; Region: DUF262; pfam03235 480224006433 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 480224006434 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 480224006435 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 480224006436 active site 480224006437 motif I; other site 480224006438 motif II; other site 480224006439 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 480224006440 Fic family protein [Function unknown]; Region: COG3177 480224006441 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 480224006442 Fic/DOC family; Region: Fic; pfam02661 480224006443 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 480224006444 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 480224006445 putative active site [active] 480224006446 putative metal binding site [ion binding]; other site 480224006447 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 480224006448 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 480224006449 GIY-YIG motif/motif A; other site 480224006450 active site 480224006451 catalytic site [active] 480224006452 putative DNA binding site [nucleotide binding]; other site 480224006453 metal binding site [ion binding]; metal-binding site 480224006454 UvrB/uvrC motif; Region: UVR; pfam02151 480224006455 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 480224006456 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 480224006457 DNA binding site [nucleotide binding] 480224006458 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 480224006459 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 480224006460 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 480224006461 Protein of unknown function DUF58; Region: DUF58; pfam01882 480224006462 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 480224006463 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 480224006464 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 480224006465 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 480224006466 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 480224006467 DNA binding residues [nucleotide binding] 480224006468 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 480224006469 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 480224006470 Ligand Binding Site [chemical binding]; other site 480224006471 TilS substrate C-terminal domain; Region: TilS_C; cl17443 480224006472 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 480224006473 active site 480224006474 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 480224006475 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 480224006476 Walker A motif; other site 480224006477 ATP binding site [chemical binding]; other site 480224006478 Walker B motif; other site 480224006479 arginine finger; other site 480224006480 Peptidase family M41; Region: Peptidase_M41; pfam01434 480224006481 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 480224006482 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 480224006483 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 480224006484 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 480224006485 pantothenate kinase; Provisional; Region: PRK05439 480224006486 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 480224006487 ATP-binding site [chemical binding]; other site 480224006488 CoA-binding site [chemical binding]; other site 480224006489 Mg2+-binding site [ion binding]; other site 480224006490 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 480224006491 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 480224006492 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 480224006493 acyl-activating enzyme (AAE) consensus motif; other site 480224006494 acyl-activating enzyme (AAE) consensus motif; other site 480224006495 putative AMP binding site [chemical binding]; other site 480224006496 putative active site [active] 480224006497 putative CoA binding site [chemical binding]; other site 480224006498 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 480224006499 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 480224006500 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 480224006501 16S/18S rRNA binding site [nucleotide binding]; other site 480224006502 S13e-L30e interaction site [polypeptide binding]; other site 480224006503 25S rRNA binding site [nucleotide binding]; other site 480224006504 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 480224006505 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 480224006506 RNase E interface [polypeptide binding]; other site 480224006507 trimer interface [polypeptide binding]; other site 480224006508 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 480224006509 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 480224006510 RNase E interface [polypeptide binding]; other site 480224006511 trimer interface [polypeptide binding]; other site 480224006512 active site 480224006513 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 480224006514 putative nucleic acid binding region [nucleotide binding]; other site 480224006515 G-X-X-G motif; other site 480224006516 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 480224006517 RNA binding site [nucleotide binding]; other site 480224006518 domain interface; other site 480224006519 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 480224006520 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 480224006521 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 480224006522 DEAD-like helicases superfamily; Region: DEXDc; smart00487 480224006523 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 480224006524 ATP binding site [chemical binding]; other site 480224006525 putative Mg++ binding site [ion binding]; other site 480224006526 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 480224006527 nucleotide binding region [chemical binding]; other site 480224006528 ATP-binding site [chemical binding]; other site 480224006529 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 480224006530 signal recognition particle protein; Provisional; Region: PRK10867 480224006531 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 480224006532 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 480224006533 P loop; other site 480224006534 GTP binding site [chemical binding]; other site 480224006535 Signal peptide binding domain; Region: SRP_SPB; pfam02978 480224006536 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 480224006537 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 480224006538 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 480224006539 G-X-X-G motif; other site 480224006540 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 480224006541 RimM N-terminal domain; Region: RimM; pfam01782 480224006542 PRC-barrel domain; Region: PRC; pfam05239 480224006543 Response regulator receiver domain; Region: Response_reg; pfam00072 480224006544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224006545 active site 480224006546 phosphorylation site [posttranslational modification] 480224006547 intermolecular recognition site; other site 480224006548 dimerization interface [polypeptide binding]; other site 480224006549 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224006550 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224006551 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 480224006552 PAS domain; Region: PAS; smart00091 480224006553 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224006554 dimer interface [polypeptide binding]; other site 480224006555 phosphorylation site [posttranslational modification] 480224006556 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224006557 ATP binding site [chemical binding]; other site 480224006558 Mg2+ binding site [ion binding]; other site 480224006559 G-X-G motif; other site 480224006560 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 480224006561 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 480224006562 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 480224006563 metal binding site [ion binding]; metal-binding site 480224006564 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 480224006565 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 480224006566 purine monophosphate binding site [chemical binding]; other site 480224006567 dimer interface [polypeptide binding]; other site 480224006568 putative catalytic residues [active] 480224006569 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 480224006570 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 480224006571 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 480224006572 Transcriptional regulators [Transcription]; Region: MarR; COG1846 480224006573 MarR family; Region: MarR_2; pfam12802 480224006574 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 480224006575 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 480224006576 G1 box; other site 480224006577 GTP/Mg2+ binding site [chemical binding]; other site 480224006578 G2 box; other site 480224006579 Switch I region; other site 480224006580 G3 box; other site 480224006581 Switch II region; other site 480224006582 G4 box; other site 480224006583 G5 box; other site 480224006584 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 480224006585 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 480224006586 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 480224006587 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224006588 GAF domain; Region: GAF_3; pfam13492 480224006589 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 480224006590 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224006591 putative active site [active] 480224006592 heme pocket [chemical binding]; other site 480224006593 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224006594 dimer interface [polypeptide binding]; other site 480224006595 phosphorylation site [posttranslational modification] 480224006596 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224006597 ATP binding site [chemical binding]; other site 480224006598 Mg2+ binding site [ion binding]; other site 480224006599 G-X-G motif; other site 480224006600 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 480224006601 Protein of unknown function DUF58; Region: DUF58; pfam01882 480224006602 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 480224006603 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 480224006604 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 480224006605 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 480224006606 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 480224006607 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 480224006608 motif II; other site 480224006609 Response regulator receiver domain; Region: Response_reg; pfam00072 480224006610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224006611 active site 480224006612 phosphorylation site [posttranslational modification] 480224006613 intermolecular recognition site; other site 480224006614 dimerization interface [polypeptide binding]; other site 480224006615 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 480224006616 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 480224006617 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 480224006618 NAD(P) binding site [chemical binding]; other site 480224006619 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 480224006620 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 480224006621 Coenzyme A binding pocket [chemical binding]; other site 480224006622 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 480224006623 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 480224006624 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 480224006625 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 480224006626 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 480224006627 HSP70 interaction site [polypeptide binding]; other site 480224006628 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 480224006629 substrate binding site [polypeptide binding]; other site 480224006630 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 480224006631 Zn binding sites [ion binding]; other site 480224006632 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 480224006633 dimer interface [polypeptide binding]; other site 480224006634 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 480224006635 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 480224006636 nucleotide binding site [chemical binding]; other site 480224006637 NEF interaction site [polypeptide binding]; other site 480224006638 SBD interface [polypeptide binding]; other site 480224006639 GrpE; Region: GrpE; pfam01025 480224006640 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 480224006641 dimer interface [polypeptide binding]; other site 480224006642 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 480224006643 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 480224006644 Beta-propeller repeat; Region: SBBP; pfam06739 480224006645 Beta-propeller repeat; Region: SBBP; pfam06739 480224006646 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 480224006647 Beta-propeller repeat; Region: SBBP; pfam06739 480224006648 Beta-propeller repeat; Region: SBBP; pfam06739 480224006649 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 480224006650 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 480224006651 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 480224006652 dimer interface [polypeptide binding]; other site 480224006653 PYR/PP interface [polypeptide binding]; other site 480224006654 TPP binding site [chemical binding]; other site 480224006655 substrate binding site [chemical binding]; other site 480224006656 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 480224006657 Domain of unknown function; Region: EKR; pfam10371 480224006658 4Fe-4S binding domain; Region: Fer4_6; pfam12837 480224006659 4Fe-4S binding domain; Region: Fer4; pfam00037 480224006660 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 480224006661 TPP-binding site [chemical binding]; other site 480224006662 dimer interface [polypeptide binding]; other site 480224006663 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 480224006664 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 480224006665 putative active site [active] 480224006666 putative FMN binding site [chemical binding]; other site 480224006667 putative substrate binding site [chemical binding]; other site 480224006668 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 480224006669 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 480224006670 MFS/sugar transport protein; Region: MFS_2; pfam13347 480224006671 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 480224006672 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 480224006673 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 480224006674 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 480224006675 catalytic residue [active] 480224006676 short chain dehydrogenase; Provisional; Region: PRK08263 480224006677 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 480224006678 NADP binding site [chemical binding]; other site 480224006679 active site 480224006680 steroid binding site; other site 480224006681 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 480224006682 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 480224006683 PYR/PP interface [polypeptide binding]; other site 480224006684 dimer interface [polypeptide binding]; other site 480224006685 TPP binding site [chemical binding]; other site 480224006686 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 480224006687 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 480224006688 TPP-binding site; other site 480224006689 dimer interface [polypeptide binding]; other site 480224006690 hypothetical protein; Provisional; Region: PRK08201 480224006691 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 480224006692 metal binding site [ion binding]; metal-binding site 480224006693 putative dimer interface [polypeptide binding]; other site 480224006694 geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023 480224006695 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 480224006696 bacteriochlorophyll/chlorophyll synthetase; Region: chlor_syn_BchG; TIGR01476 480224006697 UbiA prenyltransferase family; Region: UbiA; pfam01040 480224006698 Cytochrome C subunit of the bacterial photosynthetic reaction center; Region: CytoC_RC; cd09224 480224006699 subunit interface [polypeptide binding]; other site 480224006700 Heme binding sites [chemical binding]; other site 480224006701 Antenna complex alpha/beta subunit; Region: LHC; pfam00556 480224006702 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 480224006703 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 480224006704 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 480224006705 Walker A/P-loop; other site 480224006706 ATP binding site [chemical binding]; other site 480224006707 Q-loop/lid; other site 480224006708 ABC transporter signature motif; other site 480224006709 Walker B; other site 480224006710 D-loop; other site 480224006711 H-loop/switch region; other site 480224006712 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 480224006713 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 480224006714 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 480224006715 Walker A/P-loop; other site 480224006716 ATP binding site [chemical binding]; other site 480224006717 Q-loop/lid; other site 480224006718 ABC transporter signature motif; other site 480224006719 Walker B; other site 480224006720 D-loop; other site 480224006721 H-loop/switch region; other site 480224006722 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 480224006723 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224006724 active site 480224006725 phosphorylation site [posttranslational modification] 480224006726 intermolecular recognition site; other site 480224006727 dimerization interface [polypeptide binding]; other site 480224006728 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 480224006729 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224006730 dimer interface [polypeptide binding]; other site 480224006731 phosphorylation site [posttranslational modification] 480224006732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224006733 ATP binding site [chemical binding]; other site 480224006734 Mg2+ binding site [ion binding]; other site 480224006735 G-X-G motif; other site 480224006736 Cache domain; Region: Cache_1; pfam02743 480224006737 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 480224006738 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 480224006739 dimerization interface [polypeptide binding]; other site 480224006740 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224006741 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 480224006742 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224006743 dimer interface [polypeptide binding]; other site 480224006744 phosphorylation site [posttranslational modification] 480224006745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224006746 ATP binding site [chemical binding]; other site 480224006747 Mg2+ binding site [ion binding]; other site 480224006748 G-X-G motif; other site 480224006749 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 480224006750 amidase catalytic site [active] 480224006751 Zn binding residues [ion binding]; other site 480224006752 substrate binding site [chemical binding]; other site 480224006753 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 480224006754 PA14 domain; Region: PA14; cl08459 480224006755 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 480224006756 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 480224006757 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 480224006758 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 480224006759 active site 480224006760 NTP binding site [chemical binding]; other site 480224006761 metal binding triad [ion binding]; metal-binding site 480224006762 antibiotic binding site [chemical binding]; other site 480224006763 Protein of unknown function DUF86; Region: DUF86; cl01031 480224006764 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 480224006765 active site 480224006766 NTP binding site [chemical binding]; other site 480224006767 metal binding triad [ion binding]; metal-binding site 480224006768 antibiotic binding site [chemical binding]; other site 480224006769 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 480224006770 active site 480224006771 dimer interface [polypeptide binding]; other site 480224006772 metal binding site [ion binding]; metal-binding site 480224006773 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 480224006774 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 480224006775 dimer interface [polypeptide binding]; other site 480224006776 putative functional site; other site 480224006777 putative MPT binding site; other site 480224006778 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 480224006779 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 480224006780 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 480224006781 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 480224006782 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 480224006783 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 480224006784 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 480224006785 Walker A/P-loop; other site 480224006786 ATP binding site [chemical binding]; other site 480224006787 Q-loop/lid; other site 480224006788 ABC transporter signature motif; other site 480224006789 Walker B; other site 480224006790 D-loop; other site 480224006791 H-loop/switch region; other site 480224006792 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 480224006793 putative carbohydrate binding site [chemical binding]; other site 480224006794 VanZ like family; Region: VanZ; pfam04892 480224006795 Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102 480224006796 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 480224006797 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 480224006798 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 480224006799 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 480224006800 NAD binding site [chemical binding]; other site 480224006801 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 480224006802 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 480224006803 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 480224006804 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 480224006805 active site 480224006806 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 480224006807 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 480224006808 NodB motif; other site 480224006809 active site 480224006810 catalytic site [active] 480224006811 metal binding site [ion binding]; metal-binding site 480224006812 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537 480224006813 ATP-sulfurylase; Region: ATPS; cd00517 480224006814 active site 480224006815 HXXH motif; other site 480224006816 flexible loop; other site 480224006817 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 480224006818 ligand-binding site [chemical binding]; other site 480224006819 sulfotransferase; Region: PLN02164 480224006820 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 480224006821 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 480224006822 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 480224006823 putative trimer interface [polypeptide binding]; other site 480224006824 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 480224006825 trimer interface [polypeptide binding]; other site 480224006826 active site 480224006827 substrate binding site [chemical binding]; other site 480224006828 putative CoA binding site [chemical binding]; other site 480224006829 CoA binding site [chemical binding]; other site 480224006830 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 480224006831 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 480224006832 active site 480224006833 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 480224006834 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224006835 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 480224006836 Chain length determinant protein; Region: Wzz; cl15801 480224006837 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 480224006838 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 480224006839 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 480224006840 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 480224006841 HlyD family secretion protein; Region: HlyD_3; pfam13437 480224006842 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 480224006843 extended (e) SDRs; Region: SDR_e; cd08946 480224006844 NAD(P) binding site [chemical binding]; other site 480224006845 active site 480224006846 substrate binding site [chemical binding]; other site 480224006847 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 480224006848 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 480224006849 NADP binding site [chemical binding]; other site 480224006850 active site 480224006851 putative substrate binding site [chemical binding]; other site 480224006852 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 480224006853 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 480224006854 metal-binding site 480224006855 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 480224006856 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 480224006857 active site 480224006858 putative glycosyl transferase; Provisional; Region: PRK10063 480224006859 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 480224006860 metal-binding site 480224006861 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224006862 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 480224006863 YdjC-like protein; Region: YdjC; pfam04794 480224006864 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 480224006865 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 480224006866 active site 480224006867 CoA binding site [chemical binding]; other site 480224006868 AMP binding site [chemical binding]; other site 480224006869 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224006870 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 480224006871 PAS domain; Region: PAS; smart00091 480224006872 PAS domain; Region: PAS_9; pfam13426 480224006873 putative active site [active] 480224006874 heme pocket [chemical binding]; other site 480224006875 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224006876 PAS fold; Region: PAS_3; pfam08447 480224006877 putative active site [active] 480224006878 heme pocket [chemical binding]; other site 480224006879 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224006880 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224006881 PAS fold; Region: PAS_3; pfam08447 480224006882 putative active site [active] 480224006883 heme pocket [chemical binding]; other site 480224006884 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224006885 ATP binding site [chemical binding]; other site 480224006886 Mg2+ binding site [ion binding]; other site 480224006887 G-X-G motif; other site 480224006888 Response regulator receiver domain; Region: Response_reg; pfam00072 480224006889 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224006890 active site 480224006891 phosphorylation site [posttranslational modification] 480224006892 intermolecular recognition site; other site 480224006893 dimerization interface [polypeptide binding]; other site 480224006894 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 480224006895 FAD binding domain; Region: FAD_binding_4; pfam01565 480224006896 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 480224006897 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 480224006898 FAD binding domain; Region: FAD_binding_4; pfam01565 480224006899 FAD binding domain; Region: FAD_binding_4; pfam01565 480224006900 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 480224006901 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 480224006902 FAD binding domain; Region: FAD_binding_4; pfam01565 480224006903 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 480224006904 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 480224006905 Cysteine-rich domain; Region: CCG; pfam02754 480224006906 Cysteine-rich domain; Region: CCG; pfam02754 480224006907 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 480224006908 molybdopterin cofactor binding site; other site 480224006909 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 480224006910 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 480224006911 4Fe-4S binding domain; Region: Fer4_2; pfam12797 480224006912 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 480224006913 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 480224006914 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 480224006915 heme-binding residues [chemical binding]; other site 480224006916 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 480224006917 Cu(I) binding site [ion binding]; other site 480224006918 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 480224006919 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 480224006920 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 480224006921 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 480224006922 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 480224006923 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 480224006924 Subunit I/III interface [polypeptide binding]; other site 480224006925 caa(3)-type oxidase, subunit IV; Region: caa3_sub_IV; TIGR02229 480224006926 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 480224006927 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 480224006928 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 480224006929 motif II; other site 480224006930 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 480224006931 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 480224006932 Coenzyme A binding pocket [chemical binding]; other site 480224006933 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 480224006934 Coenzyme A binding pocket [chemical binding]; other site 480224006935 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 480224006936 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 480224006937 Coenzyme A binding pocket [chemical binding]; other site 480224006938 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 480224006939 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 480224006940 Low molecular weight phosphatase family; Region: LMWPc; cl00105 480224006941 active site 480224006942 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 480224006943 active site 480224006944 metal binding site [ion binding]; metal-binding site 480224006945 homotetramer interface [polypeptide binding]; other site 480224006946 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 480224006947 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 480224006948 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 480224006949 non-specific DNA binding site [nucleotide binding]; other site 480224006950 salt bridge; other site 480224006951 sequence-specific DNA binding site [nucleotide binding]; other site 480224006952 Cupin domain; Region: Cupin_2; pfam07883 480224006953 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 480224006954 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 480224006955 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 480224006956 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 480224006957 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 480224006958 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 480224006959 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 480224006960 Walker A motif; other site 480224006961 ATP binding site [chemical binding]; other site 480224006962 Walker B motif; other site 480224006963 arginine finger; other site 480224006964 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 480224006965 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 480224006966 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 480224006967 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 480224006968 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 480224006969 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 480224006970 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 480224006971 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 480224006972 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 480224006973 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 480224006974 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 480224006975 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 480224006976 active site 480224006977 nucleotide binding site [chemical binding]; other site 480224006978 HIGH motif; other site 480224006979 KMSKS motif; other site 480224006980 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 480224006981 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 480224006982 glucose-6-phosphate isomerase; Provisional; Region: PRK00973 480224006983 active site 480224006984 dimer interface [polypeptide binding]; other site 480224006985 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 480224006986 dimer interface [polypeptide binding]; other site 480224006987 active site 480224006988 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 480224006989 elongation factor Tu; Reviewed; Region: PRK00049 480224006990 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 480224006991 G1 box; other site 480224006992 GEF interaction site [polypeptide binding]; other site 480224006993 GTP/Mg2+ binding site [chemical binding]; other site 480224006994 Switch I region; other site 480224006995 G2 box; other site 480224006996 G3 box; other site 480224006997 Switch II region; other site 480224006998 G4 box; other site 480224006999 G5 box; other site 480224007000 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 480224007001 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 480224007002 Antibiotic Binding Site [chemical binding]; other site 480224007003 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 480224007004 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 480224007005 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 480224007006 putative homodimer interface [polypeptide binding]; other site 480224007007 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 480224007008 heterodimer interface [polypeptide binding]; other site 480224007009 homodimer interface [polypeptide binding]; other site 480224007010 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 480224007011 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 480224007012 23S rRNA interface [nucleotide binding]; other site 480224007013 L7/L12 interface [polypeptide binding]; other site 480224007014 putative thiostrepton binding site; other site 480224007015 L25 interface [polypeptide binding]; other site 480224007016 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 480224007017 mRNA/rRNA interface [nucleotide binding]; other site 480224007018 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 480224007019 23S rRNA interface [nucleotide binding]; other site 480224007020 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 480224007021 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 480224007022 L11 interface [polypeptide binding]; other site 480224007023 putative EF-Tu interaction site [polypeptide binding]; other site 480224007024 putative EF-G interaction site [polypeptide binding]; other site 480224007025 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 480224007026 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 480224007027 active site 480224007028 catalytic motif [active] 480224007029 Zn binding site [ion binding]; other site 480224007030 Domain of unknown function DUF21; Region: DUF21; pfam01595 480224007031 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 480224007032 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 480224007033 Transporter associated domain; Region: CorC_HlyC; smart01091 480224007034 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 480224007035 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 480224007036 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 480224007037 active site 480224007038 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 480224007039 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 480224007040 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 480224007041 ABC transporter; Region: ABC_tran_2; pfam12848 480224007042 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 480224007043 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 480224007044 catalytic motif [active] 480224007045 Zn binding site [ion binding]; other site 480224007046 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 480224007047 RibD C-terminal domain; Region: RibD_C; cl17279 480224007048 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 480224007049 Lumazine binding domain; Region: Lum_binding; pfam00677 480224007050 Lumazine binding domain; Region: Lum_binding; pfam00677 480224007051 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 480224007052 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 480224007053 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 480224007054 dimerization interface [polypeptide binding]; other site 480224007055 active site 480224007056 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 480224007057 homopentamer interface [polypeptide binding]; other site 480224007058 active site 480224007059 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 480224007060 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 480224007061 NAD(P) binding site [chemical binding]; other site 480224007062 active site 480224007063 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 480224007064 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 480224007065 protein binding site [polypeptide binding]; other site 480224007066 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 480224007067 putative active site [active] 480224007068 putative CoA binding site [chemical binding]; other site 480224007069 nudix motif; other site 480224007070 metal binding site [ion binding]; metal-binding site 480224007071 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 480224007072 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 480224007073 inhibitor-cofactor binding pocket; inhibition site 480224007074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224007075 catalytic residue [active] 480224007076 Pantoate-beta-alanine ligase; Region: PanC; cd00560 480224007077 pantoate--beta-alanine ligase; Region: panC; TIGR00018 480224007078 active site 480224007079 ATP-binding site [chemical binding]; other site 480224007080 pantoate-binding site; other site 480224007081 HXXH motif; other site 480224007082 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 480224007083 oligomerization interface [polypeptide binding]; other site 480224007084 active site 480224007085 metal binding site [ion binding]; metal-binding site 480224007086 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 480224007087 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 480224007088 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 480224007089 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 480224007090 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 480224007091 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 480224007092 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 480224007093 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 480224007094 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 480224007095 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 480224007096 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 480224007097 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12509 480224007098 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 480224007099 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 480224007100 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 480224007101 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 480224007102 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 480224007103 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 480224007104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 480224007105 H+ Antiporter protein; Region: 2A0121; TIGR00900 480224007106 putative substrate translocation pore; other site 480224007107 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 480224007108 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 480224007109 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 480224007110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 480224007111 Major Facilitator Superfamily; Region: MFS_1; pfam07690 480224007112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 480224007113 GAF domain; Region: GAF_2; pfam13185 480224007114 GAF domain; Region: GAF_3; pfam13492 480224007115 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224007116 GAF domain; Region: GAF; pfam01590 480224007117 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 480224007118 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 480224007119 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 480224007120 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224007121 S-adenosylmethionine binding site [chemical binding]; other site 480224007122 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 480224007123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224007124 active site 480224007125 phosphorylation site [posttranslational modification] 480224007126 intermolecular recognition site; other site 480224007127 dimerization interface [polypeptide binding]; other site 480224007128 ANTAR domain; Region: ANTAR; pfam03861 480224007129 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 480224007130 homotrimer interaction site [polypeptide binding]; other site 480224007131 active site 480224007132 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 480224007133 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 480224007134 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 480224007135 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 480224007136 active site 480224007137 multimer interface [polypeptide binding]; other site 480224007138 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 480224007139 predicted active site [active] 480224007140 catalytic triad [active] 480224007141 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 480224007142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 480224007143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 480224007144 Walker A motif; other site 480224007145 Walker A/P-loop; other site 480224007146 ATP binding site [chemical binding]; other site 480224007147 ATP binding site [chemical binding]; other site 480224007148 Walker B motif; other site 480224007149 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 480224007150 RxxxH motif; other site 480224007151 thymidylate kinase; Validated; Region: tmk; PRK00698 480224007152 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 480224007153 TMP-binding site; other site 480224007154 ATP-binding site [chemical binding]; other site 480224007155 Protein of unknown function (DUF970); Region: DUF970; pfam06153 480224007156 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 480224007157 Double zinc ribbon; Region: DZR; pfam12773 480224007158 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 480224007159 putative active site pocket [active] 480224007160 cleavage site 480224007161 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 480224007162 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 480224007163 peptide binding site [polypeptide binding]; other site 480224007164 dimer interface [polypeptide binding]; other site 480224007165 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 480224007166 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 480224007167 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 480224007168 pyrroline-5-carboxylate reductase; Region: PLN02688 480224007169 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 480224007170 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 480224007171 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 480224007172 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 480224007173 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 480224007174 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 480224007175 putative active site [active] 480224007176 putative metal binding site [ion binding]; other site 480224007177 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 480224007178 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 480224007179 Walker A/P-loop; other site 480224007180 ATP binding site [chemical binding]; other site 480224007181 Q-loop/lid; other site 480224007182 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 480224007183 ABC transporter signature motif; other site 480224007184 Walker B; other site 480224007185 D-loop; other site 480224007186 H-loop/switch region; other site 480224007187 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 480224007188 Transcriptional regulator [Transcription]; Region: LysR; COG0583 480224007189 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 480224007190 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 480224007191 dimerization interface [polypeptide binding]; other site 480224007192 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 480224007193 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 480224007194 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 480224007195 nucleotide binding site [chemical binding]; other site 480224007196 NEF interaction site [polypeptide binding]; other site 480224007197 SBD interface [polypeptide binding]; other site 480224007198 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 480224007199 cyclase homology domain; Region: CHD; cd07302 480224007200 nucleotidyl binding site; other site 480224007201 metal binding site [ion binding]; metal-binding site 480224007202 dimer interface [polypeptide binding]; other site 480224007203 cyclase homology domain; Region: CHD; cd07302 480224007204 nucleotidyl binding site; other site 480224007205 metal binding site [ion binding]; metal-binding site 480224007206 dimer interface [polypeptide binding]; other site 480224007207 Predicted ATPase [General function prediction only]; Region: COG3899 480224007208 AAA ATPase domain; Region: AAA_16; pfam13191 480224007209 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 480224007210 TPR motif; other site 480224007211 binding surface 480224007212 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 480224007213 putative active site [active] 480224007214 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 480224007215 cyclase homology domain; Region: CHD; cd07302 480224007216 nucleotidyl binding site; other site 480224007217 metal binding site [ion binding]; metal-binding site 480224007218 dimer interface [polypeptide binding]; other site 480224007219 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224007220 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 480224007221 Protein of unknown function (DUF970); Region: DUF970; cl17525 480224007222 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 480224007223 active site 480224007224 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 480224007225 Predicted ATPase [General function prediction only]; Region: COG3899 480224007226 AAA ATPase domain; Region: AAA_16; pfam13191 480224007227 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224007228 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224007229 binding surface 480224007230 TPR motif; other site 480224007231 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 480224007232 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 480224007233 Walker A/P-loop; other site 480224007234 ATP binding site [chemical binding]; other site 480224007235 Q-loop/lid; other site 480224007236 ABC transporter signature motif; other site 480224007237 Walker B; other site 480224007238 D-loop; other site 480224007239 H-loop/switch region; other site 480224007240 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 480224007241 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 480224007242 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 480224007243 Walker A/P-loop; other site 480224007244 ATP binding site [chemical binding]; other site 480224007245 Q-loop/lid; other site 480224007246 ABC transporter signature motif; other site 480224007247 Walker B; other site 480224007248 D-loop; other site 480224007249 H-loop/switch region; other site 480224007250 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 480224007251 Isochorismatase family; Region: Isochorismatase; pfam00857 480224007252 N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015 480224007253 catalytic triad [active] 480224007254 substrate binding site [chemical binding]; other site 480224007255 domain interfaces; other site 480224007256 conserved cis-peptide bond; other site 480224007257 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 480224007258 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 480224007259 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 480224007260 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 480224007261 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 480224007262 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 480224007263 active site 480224007264 catalytic residues [active] 480224007265 metal binding site [ion binding]; metal-binding site 480224007266 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 480224007267 CoA-transferase family III; Region: CoA_transf_3; pfam02515 480224007268 Transcriptional regulators [Transcription]; Region: GntR; COG1802 480224007269 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 480224007270 DNA-binding site [nucleotide binding]; DNA binding site 480224007271 FCD domain; Region: FCD; pfam07729 480224007272 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 480224007273 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 480224007274 Probable Catalytic site; other site 480224007275 metal-binding site 480224007276 CRISPR/Cas system-associated protein Csx3; Region: Csx3_III-U; cl09837 480224007277 CRISPR/Cas system-associated protein Csx3; Region: Csx3_III-U; cd09740 480224007278 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09741 480224007279 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 480224007280 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 480224007281 DNA binding residues [nucleotide binding] 480224007282 Domain of unknown function (DUF1887); Region: DUF1887; pfam09002 480224007283 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 480224007284 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 480224007285 CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cd09700 480224007286 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 480224007287 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 480224007288 CRISPR-associated protein, TIGR03984 family; Region: TIGR03984 480224007289 CRISPR-associated protein; Region: TIGR03986 480224007290 AAA domain; Region: AAA_23; pfam13476 480224007291 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 480224007292 Walker A/P-loop; other site 480224007293 ATP binding site [chemical binding]; other site 480224007294 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 480224007295 non-specific DNA binding site [nucleotide binding]; other site 480224007296 salt bridge; other site 480224007297 sequence-specific DNA binding site [nucleotide binding]; other site 480224007298 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 480224007299 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 480224007300 Double zinc ribbon; Region: DZR; pfam12773 480224007301 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 480224007302 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 480224007303 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 480224007304 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 480224007305 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 480224007306 putative NAD(P) binding site [chemical binding]; other site 480224007307 putative substrate binding site [chemical binding]; other site 480224007308 catalytic Zn binding site [ion binding]; other site 480224007309 structural Zn binding site [ion binding]; other site 480224007310 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 480224007311 N- and C-terminal domain interface [polypeptide binding]; other site 480224007312 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 480224007313 active site 480224007314 putative catalytic site [active] 480224007315 metal binding site [ion binding]; metal-binding site 480224007316 ATP binding site [chemical binding]; other site 480224007317 carbohydrate binding site [chemical binding]; other site 480224007318 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase; Region: RhaD_aldol-ADH; TIGR02632 480224007319 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 480224007320 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 480224007321 NAD(P) binding site [chemical binding]; other site 480224007322 active site 480224007323 L-rhamnose isomerase; Provisional; Region: PRK01076 480224007324 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 480224007325 Domain of unknown function (DUF718); Region: DUF718; pfam05336 480224007326 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 480224007327 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 480224007328 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 480224007329 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 480224007330 ligand binding site [chemical binding]; other site 480224007331 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 480224007332 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 480224007333 TM-ABC transporter signature motif; other site 480224007334 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 480224007335 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 480224007336 TM-ABC transporter signature motif; other site 480224007337 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 480224007338 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 480224007339 Walker A/P-loop; other site 480224007340 ATP binding site [chemical binding]; other site 480224007341 Q-loop/lid; other site 480224007342 ABC transporter signature motif; other site 480224007343 Walker B; other site 480224007344 D-loop; other site 480224007345 H-loop/switch region; other site 480224007346 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 480224007347 transcriptional repressor UlaR; Provisional; Region: PRK13509 480224007348 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 480224007349 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 480224007350 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 480224007351 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 480224007352 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 480224007353 CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cd09700 480224007354 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09683 480224007355 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 480224007356 CRISPR-associated protein, TIGR03984 family; Region: TIGR03984 480224007357 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 480224007358 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 480224007359 putative active site [active] 480224007360 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09741 480224007361 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 480224007362 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 480224007363 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 480224007364 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 480224007365 active site 480224007366 (T/H)XGH motif; other site 480224007367 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 480224007368 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 480224007369 phage shock protein A; Region: phageshock_pspA; TIGR02977 480224007370 thymidine kinase; Provisional; Region: PRK04296 480224007371 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 480224007372 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 480224007373 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 480224007374 NAD binding site [chemical binding]; other site 480224007375 substrate binding site [chemical binding]; other site 480224007376 homodimer interface [polypeptide binding]; other site 480224007377 active site 480224007378 AIR carboxylase; Region: AIRC; pfam00731 480224007379 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 480224007380 ATP-grasp domain; Region: ATP-grasp; pfam02222 480224007381 Predicted transcriptional regulator [Transcription]; Region: COG2378 480224007382 HTH domain; Region: HTH_11; pfam08279 480224007383 WYL domain; Region: WYL; pfam13280 480224007384 Ribosomal protein L31; Region: Ribosomal_L31; pfam01197 480224007385 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 480224007386 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 480224007387 Response regulator receiver domain; Region: Response_reg; pfam00072 480224007388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224007389 active site 480224007390 phosphorylation site [posttranslational modification] 480224007391 intermolecular recognition site; other site 480224007392 dimerization interface [polypeptide binding]; other site 480224007393 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 480224007394 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 480224007395 dimer interface [polypeptide binding]; other site 480224007396 anticodon binding site; other site 480224007397 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 480224007398 homodimer interface [polypeptide binding]; other site 480224007399 motif 1; other site 480224007400 active site 480224007401 motif 2; other site 480224007402 GAD domain; Region: GAD; pfam02938 480224007403 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 480224007404 active site 480224007405 motif 3; other site 480224007406 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 480224007407 aspartate-rich region 1; other site 480224007408 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 480224007409 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 480224007410 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 480224007411 active site 480224007412 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 480224007413 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 480224007414 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 480224007415 active site 480224007416 NTP binding site [chemical binding]; other site 480224007417 metal binding triad [ion binding]; metal-binding site 480224007418 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 480224007419 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 480224007420 Response regulator receiver domain; Region: Response_reg; pfam00072 480224007421 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224007422 active site 480224007423 phosphorylation site [posttranslational modification] 480224007424 intermolecular recognition site; other site 480224007425 dimerization interface [polypeptide binding]; other site 480224007426 Predicted permeases [General function prediction only]; Region: COG0679 480224007427 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 480224007428 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 480224007429 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 480224007430 DctM-like transporters; Region: DctM; pfam06808 480224007431 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 480224007432 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 480224007433 active site 480224007434 substrate-binding site [chemical binding]; other site 480224007435 metal-binding site [ion binding] 480224007436 GTP binding site [chemical binding]; other site 480224007437 Preprotein translocase SecG subunit; Region: SecG; cl09123 480224007438 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 480224007439 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 480224007440 peptide binding site [polypeptide binding]; other site 480224007441 dimer interface [polypeptide binding]; other site 480224007442 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 480224007443 FAD binding pocket [chemical binding]; other site 480224007444 FAD binding motif [chemical binding]; other site 480224007445 phosphate binding motif [ion binding]; other site 480224007446 beta-alpha-beta structure motif; other site 480224007447 NAD binding pocket [chemical binding]; other site 480224007448 Iron coordination center [ion binding]; other site 480224007449 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 480224007450 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 480224007451 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 480224007452 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 480224007453 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 480224007454 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 480224007455 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 480224007456 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 480224007457 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 480224007458 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 480224007459 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 480224007460 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 480224007461 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 480224007462 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 480224007463 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 480224007464 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 480224007465 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 480224007466 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 480224007467 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 480224007468 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 480224007469 phosphate binding site [ion binding]; other site 480224007470 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 480224007471 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 480224007472 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 480224007473 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 480224007474 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 480224007475 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 480224007476 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 480224007477 HEAT repeats; Region: HEAT_2; pfam13646 480224007478 HEAT repeats; Region: HEAT_2; pfam13646 480224007479 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 480224007480 protein binding surface [polypeptide binding]; other site 480224007481 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 480224007482 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 480224007483 nucleotide binding site [chemical binding]; other site 480224007484 Lamin Tail Domain; Region: LTD; pfam00932 480224007485 Lamin Tail Domain; Region: LTD; pfam00932 480224007486 Lamin Tail Domain; Region: LTD; pfam00932 480224007487 Lamin Tail Domain; Region: LTD; pfam00932 480224007488 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 480224007489 Active_site [active] 480224007490 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 480224007491 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 480224007492 Moco binding site; other site 480224007493 metal coordination site [ion binding]; other site 480224007494 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 480224007495 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 480224007496 [2Fe-2S] cluster binding site [ion binding]; other site 480224007497 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 480224007498 putative alpha subunit interface [polypeptide binding]; other site 480224007499 putative active site [active] 480224007500 putative substrate binding site [chemical binding]; other site 480224007501 Fe binding site [ion binding]; other site 480224007502 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 480224007503 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 480224007504 homodimer interface [polypeptide binding]; other site 480224007505 active site 480224007506 TDP-binding site; other site 480224007507 acceptor substrate-binding pocket; other site 480224007508 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 480224007509 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 480224007510 active site 480224007511 ATP binding site [chemical binding]; other site 480224007512 substrate binding site [chemical binding]; other site 480224007513 activation loop (A-loop); other site 480224007514 FOG: WD40 repeat [General function prediction only]; Region: COG2319 480224007515 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 480224007516 structural tetrad; other site 480224007517 PQQ-like domain; Region: PQQ_2; pfam13360 480224007518 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 480224007519 structural tetrad; other site 480224007520 FOG: WD40 repeat [General function prediction only]; Region: COG2319 480224007521 phytoene desaturase; Region: phytoene_desat; TIGR02731 480224007522 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 480224007523 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 480224007524 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 480224007525 aspartate aminotransferase; Provisional; Region: PRK05764 480224007526 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 480224007527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224007528 homodimer interface [polypeptide binding]; other site 480224007529 catalytic residue [active] 480224007530 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 480224007531 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 480224007532 putative ribose interaction site [chemical binding]; other site 480224007533 putative ADP binding site [chemical binding]; other site 480224007534 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 480224007535 anti sigma factor interaction site; other site 480224007536 regulatory phosphorylation site [posttranslational modification]; other site 480224007537 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 480224007538 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224007539 ATP binding site [chemical binding]; other site 480224007540 Mg2+ binding site [ion binding]; other site 480224007541 G-X-G motif; other site 480224007542 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 480224007543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224007544 ATP binding site [chemical binding]; other site 480224007545 Mg2+ binding site [ion binding]; other site 480224007546 G-X-G motif; other site 480224007547 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 480224007548 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 480224007549 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 480224007550 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 480224007551 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 480224007552 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 480224007553 16S rRNA interaction site [nucleotide binding]; other site 480224007554 streptomycin interaction site [chemical binding]; other site 480224007555 23S rRNA interaction site [nucleotide binding]; other site 480224007556 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 480224007557 30S ribosomal protein S7; Validated; Region: PRK05302 480224007558 elongation factor G; Reviewed; Region: PRK00007 480224007559 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 480224007560 G1 box; other site 480224007561 putative GEF interaction site [polypeptide binding]; other site 480224007562 GTP/Mg2+ binding site [chemical binding]; other site 480224007563 Switch I region; other site 480224007564 G2 box; other site 480224007565 G3 box; other site 480224007566 Switch II region; other site 480224007567 G4 box; other site 480224007568 G5 box; other site 480224007569 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 480224007570 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 480224007571 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 480224007572 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224007573 S-adenosylmethionine binding site [chemical binding]; other site 480224007574 elongation factor Tu; Reviewed; Region: PRK00049 480224007575 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 480224007576 G1 box; other site 480224007577 GEF interaction site [polypeptide binding]; other site 480224007578 GTP/Mg2+ binding site [chemical binding]; other site 480224007579 Switch I region; other site 480224007580 G2 box; other site 480224007581 G3 box; other site 480224007582 Switch II region; other site 480224007583 G4 box; other site 480224007584 G5 box; other site 480224007585 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 480224007586 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 480224007587 Antibiotic Binding Site [chemical binding]; other site 480224007588 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 480224007589 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 480224007590 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 480224007591 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 480224007592 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 480224007593 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 480224007594 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 480224007595 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 480224007596 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 480224007597 putative translocon binding site; other site 480224007598 protein-rRNA interface [nucleotide binding]; other site 480224007599 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 480224007600 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 480224007601 G-X-X-G motif; other site 480224007602 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 480224007603 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 480224007604 23S rRNA interface [nucleotide binding]; other site 480224007605 5S rRNA interface [nucleotide binding]; other site 480224007606 putative antibiotic binding site [chemical binding]; other site 480224007607 L25 interface [polypeptide binding]; other site 480224007608 L27 interface [polypeptide binding]; other site 480224007609 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 480224007610 23S rRNA interface [nucleotide binding]; other site 480224007611 putative translocon interaction site; other site 480224007612 signal recognition particle (SRP54) interaction site; other site 480224007613 L23 interface [polypeptide binding]; other site 480224007614 trigger factor interaction site; other site 480224007615 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 480224007616 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 480224007617 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 480224007618 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 480224007619 RNA binding site [nucleotide binding]; other site 480224007620 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 480224007621 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 480224007622 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 480224007623 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 480224007624 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 480224007625 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 480224007626 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 480224007627 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 480224007628 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 480224007629 23S rRNA interface [nucleotide binding]; other site 480224007630 5S rRNA interface [nucleotide binding]; other site 480224007631 L27 interface [polypeptide binding]; other site 480224007632 L5 interface [polypeptide binding]; other site 480224007633 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 480224007634 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 480224007635 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 480224007636 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 480224007637 23S rRNA binding site [nucleotide binding]; other site 480224007638 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 480224007639 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 480224007640 SecY translocase; Region: SecY; pfam00344 480224007641 adenylate kinase; Reviewed; Region: adk; PRK00279 480224007642 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 480224007643 AMP-binding site [chemical binding]; other site 480224007644 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 480224007645 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 480224007646 rRNA binding site [nucleotide binding]; other site 480224007647 predicted 30S ribosome binding site; other site 480224007648 Ribosomal protein L36 [Translation, ribosomal structure and biogenesis]; Region: RpmJ; COG0257 480224007649 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 480224007650 30S ribosomal protein S13; Region: bact_S13; TIGR03631 480224007651 30S ribosomal protein S11; Validated; Region: PRK05309 480224007652 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 480224007653 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 480224007654 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 480224007655 RNA binding surface [nucleotide binding]; other site 480224007656 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 480224007657 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 480224007658 alphaNTD homodimer interface [polypeptide binding]; other site 480224007659 alphaNTD - beta interaction site [polypeptide binding]; other site 480224007660 alphaNTD - beta' interaction site [polypeptide binding]; other site 480224007661 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 480224007662 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 480224007663 tRNA pseudouridine synthase ACD; Provisional; Region: PRK14588 480224007664 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 480224007665 dimerization interface 3.5A [polypeptide binding]; other site 480224007666 active site 480224007667 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 480224007668 23S rRNA interface [nucleotide binding]; other site 480224007669 L3 interface [polypeptide binding]; other site 480224007670 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 480224007671 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 480224007672 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224007673 S-adenosylmethionine binding site [chemical binding]; other site 480224007674 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 480224007675 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 480224007676 active site 480224007677 (T/H)XGH motif; other site 480224007678 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 480224007679 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 480224007680 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 480224007681 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 480224007682 dimer interface [polypeptide binding]; other site 480224007683 active site 480224007684 CoA binding pocket [chemical binding]; other site 480224007685 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 480224007686 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 480224007687 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 480224007688 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 480224007689 NAD(P) binding site [chemical binding]; other site 480224007690 active site 480224007691 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 480224007692 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 480224007693 NAD(P) binding site [chemical binding]; other site 480224007694 active site 480224007695 phytoene desaturase; Region: crtI_fam; TIGR02734 480224007696 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 480224007697 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 480224007698 ATP binding site [chemical binding]; other site 480224007699 Walker A motif; other site 480224007700 hexamer interface [polypeptide binding]; other site 480224007701 Walker B motif; other site 480224007702 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 480224007703 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 480224007704 Walker A motif; other site 480224007705 ATP binding site [chemical binding]; other site 480224007706 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224007707 binding surface 480224007708 TPR motif; other site 480224007709 TPR repeat; Region: TPR_11; pfam13414 480224007710 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14338 480224007711 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 480224007712 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 480224007713 FeS/SAM binding site; other site 480224007714 TRAM domain; Region: TRAM; pfam01938 480224007715 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 480224007716 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 480224007717 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 480224007718 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 480224007719 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 480224007720 integral membrane protein MviN; Region: mviN; TIGR01695 480224007721 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 480224007722 phytoene desaturase; Region: crtI_fam; TIGR02734 480224007723 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 480224007724 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 480224007725 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 480224007726 Cu(I) binding site [ion binding]; other site 480224007727 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 480224007728 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 480224007729 ba3-like heme-copper oxidase subunit I. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660 480224007730 Putative D-pathway homolog; other site 480224007731 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 480224007732 Low-spin heme binding site [chemical binding]; other site 480224007733 Subunit I/II interface [polypeptide binding]; other site 480224007734 Putative Q-pathway; other site 480224007735 Putative alternate electron transfer pathway; other site 480224007736 Putative water exit pathway; other site 480224007737 Binuclear center (active site) [active] 480224007738 Putative K-pathway homolog; other site 480224007739 Putative proton exit pathway; other site 480224007740 Subunit I/IIa interface [polypeptide binding]; other site 480224007741 Electron transfer pathway; other site 480224007742 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 480224007743 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 480224007744 Walker A/P-loop; other site 480224007745 ATP binding site [chemical binding]; other site 480224007746 Q-loop/lid; other site 480224007747 ABC transporter signature motif; other site 480224007748 Walker B; other site 480224007749 D-loop; other site 480224007750 H-loop/switch region; other site 480224007751 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 480224007752 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 480224007753 putative hemin binding site; other site 480224007754 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 480224007755 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 480224007756 ABC-ATPase subunit interface; other site 480224007757 dimer interface [polypeptide binding]; other site 480224007758 putative PBP binding regions; other site 480224007759 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 480224007760 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 480224007761 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 480224007762 FeoA domain; Region: FeoA; pfam04023 480224007763 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 480224007764 putative active site [active] 480224007765 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 480224007766 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 480224007767 dimerization interface [polypeptide binding]; other site 480224007768 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224007769 dimer interface [polypeptide binding]; other site 480224007770 phosphorylation site [posttranslational modification] 480224007771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224007772 ATP binding site [chemical binding]; other site 480224007773 Mg2+ binding site [ion binding]; other site 480224007774 G-X-G motif; other site 480224007775 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 480224007776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224007777 active site 480224007778 phosphorylation site [posttranslational modification] 480224007779 intermolecular recognition site; other site 480224007780 dimerization interface [polypeptide binding]; other site 480224007781 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 480224007782 DNA binding site [nucleotide binding] 480224007783 Domain of unknown function (DUF305); Region: DUF305; pfam03713 480224007784 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 480224007785 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 480224007786 dimerization interface [polypeptide binding]; other site 480224007787 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224007788 dimer interface [polypeptide binding]; other site 480224007789 phosphorylation site [posttranslational modification] 480224007790 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224007791 ATP binding site [chemical binding]; other site 480224007792 Mg2+ binding site [ion binding]; other site 480224007793 G-X-G motif; other site 480224007794 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 480224007795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224007796 active site 480224007797 phosphorylation site [posttranslational modification] 480224007798 intermolecular recognition site; other site 480224007799 dimerization interface [polypeptide binding]; other site 480224007800 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 480224007801 DNA binding site [nucleotide binding] 480224007802 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 480224007803 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 480224007804 Walker A/P-loop; other site 480224007805 ATP binding site [chemical binding]; other site 480224007806 Q-loop/lid; other site 480224007807 ABC transporter signature motif; other site 480224007808 Walker B; other site 480224007809 D-loop; other site 480224007810 H-loop/switch region; other site 480224007811 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 480224007812 RibD C-terminal domain; Region: RibD_C; cl17279 480224007813 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 480224007814 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 480224007815 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 480224007816 putative dimer interface [polypeptide binding]; other site 480224007817 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 480224007818 RibD C-terminal domain; Region: RibD_C; cl17279 480224007819 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 480224007820 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 480224007821 SnoaL-like domain; Region: SnoaL_2; pfam12680 480224007822 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 480224007823 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 480224007824 NAD(P) binding site [chemical binding]; other site 480224007825 active site 480224007826 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 480224007827 Serine hydrolase; Region: Ser_hydrolase; cl17834 480224007828 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 480224007829 RibD C-terminal domain; Region: RibD_C; cl17279 480224007830 RibD C-terminal domain; Region: RibD_C; cl17279 480224007831 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 480224007832 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 480224007833 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224007834 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 480224007835 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 480224007836 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 480224007837 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 480224007838 RibD C-terminal domain; Region: RibD_C; cl17279 480224007839 O-Antigen ligase; Region: Wzy_C; pfam04932 480224007840 TIR domain; Region: TIR_2; pfam13676 480224007841 CHAT domain; Region: CHAT; cl17868 480224007842 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 480224007843 putative active site [active] 480224007844 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 480224007845 Methyltransferase domain; Region: Methyltransf_31; pfam13847 480224007846 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224007847 S-adenosylmethionine binding site [chemical binding]; other site 480224007848 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 480224007849 Predicted membrane protein [Function unknown]; Region: COG1470 480224007850 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 480224007851 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 480224007852 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 480224007853 Walker A/P-loop; other site 480224007854 ATP binding site [chemical binding]; other site 480224007855 Q-loop/lid; other site 480224007856 ABC transporter signature motif; other site 480224007857 Walker B; other site 480224007858 D-loop; other site 480224007859 H-loop/switch region; other site 480224007860 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 480224007861 camphor resistance protein CrcB; Provisional; Region: PRK14215 480224007862 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 480224007863 FOG: CBS domain [General function prediction only]; Region: COG0517 480224007864 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 480224007865 FOG: CBS domain [General function prediction only]; Region: COG0517 480224007866 FOG: CBS domain [General function prediction only]; Region: COG0517 480224007867 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 480224007868 Clp protease ATP binding subunit; Region: clpC; CHL00095 480224007869 Clp amino terminal domain; Region: Clp_N; pfam02861 480224007870 Clp amino terminal domain; Region: Clp_N; pfam02861 480224007871 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 480224007872 Walker A motif; other site 480224007873 ATP binding site [chemical binding]; other site 480224007874 Walker B motif; other site 480224007875 arginine finger; other site 480224007876 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 480224007877 Walker A motif; other site 480224007878 ATP binding site [chemical binding]; other site 480224007879 Walker B motif; other site 480224007880 arginine finger; other site 480224007881 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 480224007882 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 480224007883 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 480224007884 RNA binding site [nucleotide binding]; other site 480224007885 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 480224007886 RNA binding site [nucleotide binding]; other site 480224007887 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 480224007888 RNA binding site [nucleotide binding]; other site 480224007889 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 480224007890 RNA binding site [nucleotide binding]; other site 480224007891 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 480224007892 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 480224007893 active site residue [active] 480224007894 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 480224007895 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 480224007896 active site 480224007897 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 480224007898 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 480224007899 nudix motif; other site 480224007900 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 480224007901 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 480224007902 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 480224007903 FMN binding site [chemical binding]; other site 480224007904 substrate binding site [chemical binding]; other site 480224007905 putative catalytic residue [active] 480224007906 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 480224007907 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 480224007908 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 480224007909 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 480224007910 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 480224007911 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 480224007912 active site 480224007913 Int/Topo IB signature motif; other site 480224007914 glycyl-tRNA synthetase; Provisional; Region: PRK14894 480224007915 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 480224007916 dimer interface [polypeptide binding]; other site 480224007917 motif 1; other site 480224007918 active site 480224007919 motif 2; other site 480224007920 motif 3; other site 480224007921 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 480224007922 anticodon binding site; other site 480224007923 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 480224007924 Moco binding site; other site 480224007925 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 480224007926 Predicted transcriptional regulators [Transcription]; Region: COG1695 480224007927 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 480224007928 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 480224007929 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 480224007930 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 480224007931 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 480224007932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224007933 dimer interface [polypeptide binding]; other site 480224007934 conserved gate region; other site 480224007935 putative PBP binding loops; other site 480224007936 ABC-ATPase subunit interface; other site 480224007937 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 480224007938 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 480224007939 Walker A/P-loop; other site 480224007940 ATP binding site [chemical binding]; other site 480224007941 Q-loop/lid; other site 480224007942 ABC transporter signature motif; other site 480224007943 Walker B; other site 480224007944 D-loop; other site 480224007945 H-loop/switch region; other site 480224007946 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 480224007947 haloacid dehalogenase superfamily protein; Provisional; Region: PRK14562 480224007948 Translin family; Region: Translin; cl00957 480224007949 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224007950 PAS domain; Region: PAS_9; pfam13426 480224007951 putative active site [active] 480224007952 heme pocket [chemical binding]; other site 480224007953 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 480224007954 Histidine kinase; Region: HisKA_2; pfam07568 480224007955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224007956 ATP binding site [chemical binding]; other site 480224007957 Mg2+ binding site [ion binding]; other site 480224007958 G-X-G motif; other site 480224007959 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 480224007960 tetramer interface [polypeptide binding]; other site 480224007961 dimer interface [polypeptide binding]; other site 480224007962 Response regulator receiver domain; Region: Response_reg; pfam00072 480224007963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224007964 active site 480224007965 phosphorylation site [posttranslational modification] 480224007966 intermolecular recognition site; other site 480224007967 dimerization interface [polypeptide binding]; other site 480224007968 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224007969 PAS domain; Region: PAS_9; pfam13426 480224007970 putative active site [active] 480224007971 heme pocket [chemical binding]; other site 480224007972 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 480224007973 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 480224007974 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 480224007975 catalytic residues [active] 480224007976 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 480224007977 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 480224007978 alphaNTD - beta interaction site [polypeptide binding]; other site 480224007979 alphaNTD homodimer interface [polypeptide binding]; other site 480224007980 alphaNTD - beta' interaction site [polypeptide binding]; other site 480224007981 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 480224007982 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 480224007983 transcription termination factor Rho; Provisional; Region: PRK12608 480224007984 RNA binding site [nucleotide binding]; other site 480224007985 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 480224007986 multimer interface [polypeptide binding]; other site 480224007987 Walker A motif; other site 480224007988 ATP binding site [chemical binding]; other site 480224007989 Walker B motif; other site 480224007990 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 480224007991 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 480224007992 GTP binding site; other site 480224007993 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 480224007994 structural tetrad; other site 480224007995 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 480224007996 Methyltransferase domain; Region: Methyltransf_23; pfam13489 480224007997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224007998 S-adenosylmethionine binding site [chemical binding]; other site 480224007999 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 480224008000 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 480224008001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224008002 active site 480224008003 phosphorylation site [posttranslational modification] 480224008004 intermolecular recognition site; other site 480224008005 dimerization interface [polypeptide binding]; other site 480224008006 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 480224008007 DNA binding site [nucleotide binding] 480224008008 membrane ATPase/protein kinase; Provisional; Region: PRK09435 480224008009 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 480224008010 Walker A; other site 480224008011 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 480224008012 G4 box; other site 480224008013 G5 box; other site 480224008014 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 480224008015 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 480224008016 active site 480224008017 substrate binding site [chemical binding]; other site 480224008018 coenzyme B12 binding site [chemical binding]; other site 480224008019 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 480224008020 B12 binding site [chemical binding]; other site 480224008021 cobalt ligand [ion binding]; other site 480224008022 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 480224008023 heterodimer interface [polypeptide binding]; other site 480224008024 substrate interaction site [chemical binding]; other site 480224008025 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 480224008026 glutamate carboxypeptidase; Reviewed; Region: PRK06133 480224008027 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 480224008028 metal binding site [ion binding]; metal-binding site 480224008029 dimer interface [polypeptide binding]; other site 480224008030 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 480224008031 active site 480224008032 ATP binding site [chemical binding]; other site 480224008033 Phosphotransferase enzyme family; Region: APH; pfam01636 480224008034 antibiotic binding site [chemical binding]; other site 480224008035 fumarylacetoacetase; Region: PLN02856 480224008036 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 480224008037 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 480224008038 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 480224008039 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 480224008040 putative active site [active] 480224008041 CAAX protease self-immunity; Region: Abi; pfam02517 480224008042 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 480224008043 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 480224008044 prephenate dehydrogenase; Validated; Region: PRK08507 480224008045 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 480224008046 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 480224008047 Tetramer interface [polypeptide binding]; other site 480224008048 active site 480224008049 FMN-binding site [chemical binding]; other site 480224008050 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 480224008051 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224008052 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 480224008053 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 480224008054 putative RNA binding site [nucleotide binding]; other site 480224008055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224008056 S-adenosylmethionine binding site [chemical binding]; other site 480224008057 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 480224008058 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 480224008059 ligand binding site; other site 480224008060 oligomer interface; other site 480224008061 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 480224008062 dimer interface [polypeptide binding]; other site 480224008063 N-terminal domain interface [polypeptide binding]; other site 480224008064 sulfate 1 binding site; other site 480224008065 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 480224008066 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 480224008067 ligand binding site; other site 480224008068 oligomer interface; other site 480224008069 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 480224008070 dimer interface [polypeptide binding]; other site 480224008071 N-terminal domain interface [polypeptide binding]; other site 480224008072 sulfate 1 binding site; other site 480224008073 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 480224008074 Restriction endonuclease NotI; Region: NotI; pfam12183 480224008075 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 480224008076 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 480224008077 Ligand Binding Site [chemical binding]; other site 480224008078 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 480224008079 Ligand Binding Site [chemical binding]; other site 480224008080 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 480224008081 MOSC domain; Region: MOSC; pfam03473 480224008082 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 480224008083 Ligand Binding Site [chemical binding]; other site 480224008084 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 480224008085 C-terminal peptidase (prc); Region: prc; TIGR00225 480224008086 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 480224008087 protein binding site [polypeptide binding]; other site 480224008088 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 480224008089 Domain interface; other site 480224008090 Peptide binding site; other site 480224008091 Active site tetrad [active] 480224008092 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 480224008093 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 480224008094 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224008095 homodimer interface [polypeptide binding]; other site 480224008096 catalytic residue [active] 480224008097 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 480224008098 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 480224008099 active site 480224008100 Alkaline phosphatase homologues; Region: alkPPc; smart00098 480224008101 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 480224008102 active site 480224008103 dimer interface [polypeptide binding]; other site 480224008104 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 480224008105 NMT1/THI5 like; Region: NMT1; pfam09084 480224008106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224008107 dimer interface [polypeptide binding]; other site 480224008108 conserved gate region; other site 480224008109 ABC-ATPase subunit interface; other site 480224008110 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 480224008111 trehalose synthase; Region: treS_nterm; TIGR02456 480224008112 active site 480224008113 catalytic site [active] 480224008114 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 480224008115 putative homodimer interface [polypeptide binding]; other site 480224008116 putative homotetramer interface [polypeptide binding]; other site 480224008117 putative allosteric switch controlling residues; other site 480224008118 putative metal binding site [ion binding]; other site 480224008119 putative homodimer-homodimer interface [polypeptide binding]; other site 480224008120 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 480224008121 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 480224008122 catalytic residues [active] 480224008123 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 480224008124 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 480224008125 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 480224008126 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 480224008127 dimer interface [polypeptide binding]; other site 480224008128 active site 480224008129 glycine-pyridoxal phosphate binding site [chemical binding]; other site 480224008130 folate binding site [chemical binding]; other site 480224008131 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 480224008132 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 480224008133 polyphosphate kinase; Provisional; Region: PRK05443 480224008134 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 480224008135 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 480224008136 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 480224008137 putative domain interface [polypeptide binding]; other site 480224008138 putative active site [active] 480224008139 catalytic site [active] 480224008140 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 480224008141 putative domain interface [polypeptide binding]; other site 480224008142 putative active site [active] 480224008143 catalytic site [active] 480224008144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 480224008145 putative substrate translocation pore; other site 480224008146 Major Facilitator Superfamily; Region: MFS_1; pfam07690 480224008147 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 480224008148 TIGR03663 family protein; Region: TIGR03663 480224008149 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 480224008150 Uncharacterized conserved protein [Function unknown]; Region: COG3391 480224008151 NHL repeat; Region: NHL; pfam01436 480224008152 NHL repeat; Region: NHL; pfam01436 480224008153 NHL repeat; Region: NHL; pfam01436 480224008154 NHL repeat; Region: NHL; pfam01436 480224008155 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 480224008156 ATP binding site [chemical binding]; other site 480224008157 Phosphotransferase enzyme family; Region: APH; pfam01636 480224008158 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 480224008159 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 480224008160 putative active site [active] 480224008161 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 480224008162 putative active site [active] 480224008163 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 480224008164 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 480224008165 P-loop; other site 480224008166 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 480224008167 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 480224008168 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 480224008169 light-independent protochlorophyllide reductase, B subunit; Region: DPOR_BchB; TIGR01278 480224008170 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 480224008171 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 480224008172 light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842 480224008173 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 480224008174 Tetratricopeptide repeat; Region: TPR_16; pfam13432 480224008175 cobyric acid synthase; Provisional; Region: PRK00784 480224008176 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 480224008177 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 480224008178 catalytic triad [active] 480224008179 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 480224008180 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 480224008181 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224008182 homodimer interface [polypeptide binding]; other site 480224008183 catalytic residue [active] 480224008184 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 480224008185 homotrimer interface [polypeptide binding]; other site 480224008186 Walker A motif; other site 480224008187 GTP binding site [chemical binding]; other site 480224008188 Walker B motif; other site 480224008189 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 480224008190 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 480224008191 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 480224008192 catalytic triad [active] 480224008193 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 480224008194 active site 480224008195 SAM binding site [chemical binding]; other site 480224008196 homodimer interface [polypeptide binding]; other site 480224008197 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 480224008198 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 480224008199 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 480224008200 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 480224008201 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 480224008202 active site 480224008203 SAM binding site [chemical binding]; other site 480224008204 homodimer interface [polypeptide binding]; other site 480224008205 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 480224008206 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 480224008207 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 480224008208 active site 480224008209 SAM binding site [chemical binding]; other site 480224008210 homodimer interface [polypeptide binding]; other site 480224008211 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 480224008212 active site 480224008213 SAM binding site [chemical binding]; other site 480224008214 homodimer interface [polypeptide binding]; other site 480224008215 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 480224008216 active site 480224008217 putative homodimer interface [polypeptide binding]; other site 480224008218 SAM binding site [chemical binding]; other site 480224008219 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 480224008220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224008221 S-adenosylmethionine binding site [chemical binding]; other site 480224008222 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 480224008223 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 480224008224 Precorrin-8X methylmutase; Region: CbiC; pfam02570 480224008225 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 480224008226 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 480224008227 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 480224008228 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 480224008229 putative active site [active] 480224008230 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 480224008231 putative active site [active] 480224008232 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 480224008233 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 480224008234 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 480224008235 Walker A/P-loop; other site 480224008236 ATP binding site [chemical binding]; other site 480224008237 Q-loop/lid; other site 480224008238 ABC transporter signature motif; other site 480224008239 Walker B; other site 480224008240 D-loop; other site 480224008241 H-loop/switch region; other site 480224008242 cobalt transport protein CbiN; Provisional; Region: PRK02898 480224008243 cobalt transport protein CbiM; Validated; Region: PRK08319 480224008244 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 480224008245 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 480224008246 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 480224008247 putative dimer interface [polypeptide binding]; other site 480224008248 active site pocket [active] 480224008249 putative cataytic base [active] 480224008250 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 480224008251 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 480224008252 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 480224008253 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 480224008254 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 480224008255 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 480224008256 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 480224008257 homodimer interface [polypeptide binding]; other site 480224008258 Walker A motif; other site 480224008259 ATP binding site [chemical binding]; other site 480224008260 hydroxycobalamin binding site [chemical binding]; other site 480224008261 Walker B motif; other site 480224008262 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 480224008263 BNR repeat-like domain; Region: BNR_2; pfam13088 480224008264 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 480224008265 threonine dehydratase; Reviewed; Region: PRK09224 480224008266 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 480224008267 tetramer interface [polypeptide binding]; other site 480224008268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224008269 catalytic residue [active] 480224008270 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 480224008271 putative Ile/Val binding site [chemical binding]; other site 480224008272 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 480224008273 putative Ile/Val binding site [chemical binding]; other site 480224008274 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224008275 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224008276 GAF domain; Region: GAF; pfam01590 480224008277 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 480224008278 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 480224008279 metal binding site [ion binding]; metal-binding site 480224008280 active site 480224008281 I-site; other site 480224008282 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 480224008283 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 480224008284 tetramer interface [polypeptide binding]; other site 480224008285 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224008286 catalytic residue [active] 480224008287 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 480224008288 Methyltransferase domain; Region: Methyltransf_18; pfam12847 480224008289 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 480224008290 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 480224008291 diiron binding motif [ion binding]; other site 480224008292 magnesium chelatase subunit H; Provisional; Region: PRK12493 480224008293 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 480224008294 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 480224008295 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 480224008296 PUCC protein; Region: PUCC; pfam03209 480224008297 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 480224008298 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 480224008299 tRNA; other site 480224008300 putative tRNA binding site [nucleotide binding]; other site 480224008301 putative NADP binding site [chemical binding]; other site 480224008302 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 480224008303 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 480224008304 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 480224008305 domain interfaces; other site 480224008306 active site 480224008307 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 480224008308 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 480224008309 active site 480224008310 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 480224008311 dimer interface [polypeptide binding]; other site 480224008312 active site 480224008313 Schiff base residues; other site 480224008314 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 480224008315 substrate binding site [chemical binding]; other site 480224008316 active site 480224008317 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 480224008318 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 480224008319 inhibitor-cofactor binding pocket; inhibition site 480224008320 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224008321 catalytic residue [active] 480224008322 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 480224008323 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 480224008324 oligoendopeptidase F; Region: pepF; TIGR00181 480224008325 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 480224008326 active site 480224008327 Zn binding site [ion binding]; other site 480224008328 Major Facilitator Superfamily; Region: MFS_1; pfam07690 480224008329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 480224008330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 480224008331 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 480224008332 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 480224008333 active site 480224008334 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 480224008335 Peptidase family M23; Region: Peptidase_M23; pfam01551 480224008336 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 480224008337 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 480224008338 conserved hypothetical protein; Region: TIGR02231 480224008339 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 480224008340 RNA polymerase II transcription mediator complex subunit 9; Region: Med9; pfam07544 480224008341 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 480224008342 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 480224008343 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 480224008344 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 480224008345 metal ion-dependent adhesion site (MIDAS); other site 480224008346 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 480224008347 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 480224008348 metal ion-dependent adhesion site (MIDAS); other site 480224008349 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 480224008350 FixH; Region: FixH; pfam05751 480224008351 GAF domain; Region: GAF_2; pfam13185 480224008352 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224008353 GAF domain; Region: GAF_2; pfam13185 480224008354 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224008355 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224008356 GAF domain; Region: GAF; pfam01590 480224008357 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224008358 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224008359 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224008360 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224008361 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224008362 GAF domain; Region: GAF; pfam01590 480224008363 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 480224008364 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 480224008365 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 480224008366 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 480224008367 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 480224008368 Cytochrome P450; Region: p450; cl12078 480224008369 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 480224008370 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 480224008371 classical (c) SDRs; Region: SDR_c; cd05233 480224008372 NAD(P) binding site [chemical binding]; other site 480224008373 active site 480224008374 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 480224008375 classical (c) SDRs; Region: SDR_c; cd05233 480224008376 NAD(P) binding site [chemical binding]; other site 480224008377 active site 480224008378 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 480224008379 hypothetical protein; Provisional; Region: PRK06541 480224008380 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 480224008381 inhibitor-cofactor binding pocket; inhibition site 480224008382 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224008383 catalytic residue [active] 480224008384 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 480224008385 catalytic residues [active] 480224008386 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 480224008387 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 480224008388 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 480224008389 Coenzyme A binding pocket [chemical binding]; other site 480224008390 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 480224008391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224008392 S-adenosylmethionine binding site [chemical binding]; other site 480224008393 MarR family; Region: MarR; pfam01047 480224008394 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 480224008395 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 480224008396 Competence protein; Region: Competence; pfam03772 480224008397 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 480224008398 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 480224008399 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 480224008400 Histidine kinase; Region: HisKA_3; pfam07730 480224008401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224008402 ATP binding site [chemical binding]; other site 480224008403 Mg2+ binding site [ion binding]; other site 480224008404 G-X-G motif; other site 480224008405 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 480224008406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224008407 active site 480224008408 phosphorylation site [posttranslational modification] 480224008409 intermolecular recognition site; other site 480224008410 dimerization interface [polypeptide binding]; other site 480224008411 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 480224008412 DNA binding residues [nucleotide binding] 480224008413 dimerization interface [polypeptide binding]; other site 480224008414 Methyltransferase domain; Region: Methyltransf_31; pfam13847 480224008415 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224008416 S-adenosylmethionine binding site [chemical binding]; other site 480224008417 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 480224008418 GAF domain; Region: GAF; pfam01590 480224008419 GAF domain; Region: GAF_2; pfam13185 480224008420 GAF domain; Region: GAF_3; pfam13492 480224008421 PAS domain; Region: PAS; smart00091 480224008422 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 480224008423 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 480224008424 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 480224008425 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 480224008426 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 480224008427 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 480224008428 active site 480224008429 dimer interface [polypeptide binding]; other site 480224008430 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 480224008431 acetylornithine deacetylase; Validated; Region: PRK06915 480224008432 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 480224008433 metal binding site [ion binding]; metal-binding site 480224008434 dimer interface [polypeptide binding]; other site 480224008435 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 480224008436 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 480224008437 Potassium binding sites [ion binding]; other site 480224008438 Cesium cation binding sites [ion binding]; other site 480224008439 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 480224008440 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 480224008441 active site 480224008442 catalytic triad [active] 480224008443 Cna protein B-type domain; Region: Cna_B_2; pfam13715 480224008444 translocation protein TolB; Provisional; Region: tolB; PRK02889 480224008445 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224008446 active site 480224008447 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 480224008448 phosphorylation site [posttranslational modification] 480224008449 intermolecular recognition site; other site 480224008450 dimerization interface [polypeptide binding]; other site 480224008451 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 480224008452 DNA binding residues [nucleotide binding] 480224008453 dimerization interface [polypeptide binding]; other site 480224008454 DNA polymerase III subunit beta; Validated; Region: PRK05643 480224008455 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 480224008456 putative DNA binding surface [nucleotide binding]; other site 480224008457 dimer interface [polypeptide binding]; other site 480224008458 beta-clamp/clamp loader binding surface; other site 480224008459 beta-clamp/translesion DNA polymerase binding surface; other site 480224008460 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 480224008461 active site 480224008462 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 480224008463 active site 480224008464 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 480224008465 homodecamer interface [polypeptide binding]; other site 480224008466 GTP cyclohydrolase I; Provisional; Region: PLN03044 480224008467 active site 480224008468 putative catalytic site residues [active] 480224008469 zinc binding site [ion binding]; other site 480224008470 GTP-CH-I/GFRP interaction surface; other site 480224008471 short chain dehydrogenase; Provisional; Region: PRK07454 480224008472 classical (c) SDRs; Region: SDR_c; cd05233 480224008473 NAD(P) binding site [chemical binding]; other site 480224008474 active site 480224008475 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 480224008476 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 480224008477 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 480224008478 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 480224008479 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 480224008480 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 480224008481 putative trimer interface [polypeptide binding]; other site 480224008482 putative CoA binding site [chemical binding]; other site 480224008483 Response regulator receiver domain; Region: Response_reg; pfam00072 480224008484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224008485 active site 480224008486 phosphorylation site [posttranslational modification] 480224008487 intermolecular recognition site; other site 480224008488 dimerization interface [polypeptide binding]; other site 480224008489 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 480224008490 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 480224008491 metal binding site [ion binding]; metal-binding site 480224008492 active site 480224008493 I-site; other site 480224008494 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224008495 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224008496 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224008497 GAF domain; Region: GAF_2; pfam13185 480224008498 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224008499 GAF domain; Region: GAF_3; pfam13492 480224008500 GAF domain; Region: GAF_3; pfam13492 480224008501 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224008502 GAF domain; Region: GAF; pfam01590 480224008503 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224008504 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224008505 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224008506 GAF domain; Region: GAF; pfam01590 480224008507 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224008508 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224008509 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224008510 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224008511 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224008512 GAF domain; Region: GAF_2; pfam13185 480224008513 GAF domain; Region: GAF; pfam01590 480224008514 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224008515 GAF domain; Region: GAF; pfam01590 480224008516 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 480224008517 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224008518 putative active site [active] 480224008519 heme pocket [chemical binding]; other site 480224008520 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224008521 dimer interface [polypeptide binding]; other site 480224008522 phosphorylation site [posttranslational modification] 480224008523 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224008524 ATP binding site [chemical binding]; other site 480224008525 Mg2+ binding site [ion binding]; other site 480224008526 G-X-G motif; other site 480224008527 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 480224008528 PGAP1-like protein; Region: PGAP1; pfam07819 480224008529 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 480224008530 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 480224008531 active site 480224008532 HIGH motif; other site 480224008533 nucleotide binding site [chemical binding]; other site 480224008534 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 480224008535 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 480224008536 active site 480224008537 KMSKS motif; other site 480224008538 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 480224008539 tRNA binding surface [nucleotide binding]; other site 480224008540 anticodon binding site; other site 480224008541 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 480224008542 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 480224008543 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 480224008544 Walker A/P-loop; other site 480224008545 ATP binding site [chemical binding]; other site 480224008546 Q-loop/lid; other site 480224008547 ABC transporter signature motif; other site 480224008548 Walker B; other site 480224008549 D-loop; other site 480224008550 H-loop/switch region; other site 480224008551 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 480224008552 Double zinc ribbon; Region: DZR; pfam12773 480224008553 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 480224008554 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 480224008555 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 480224008556 phosphopeptide binding site; other site 480224008557 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 480224008558 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 480224008559 metal ion-dependent adhesion site (MIDAS); other site 480224008560 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 480224008561 Double zinc ribbon; Region: DZR; pfam12773 480224008562 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 480224008563 Catalytic domain of Protein Kinases; Region: PKc; cd00180 480224008564 active site 480224008565 ATP binding site [chemical binding]; other site 480224008566 substrate binding site [chemical binding]; other site 480224008567 activation loop (A-loop); other site 480224008568 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 480224008569 Protein phosphatase 2C; Region: PP2C; pfam00481 480224008570 active site 480224008571 Double zinc ribbon; Region: DZR; pfam12773 480224008572 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 480224008573 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 480224008574 Protein phosphatase 2C; Region: PP2C; pfam00481 480224008575 active site 480224008576 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 480224008577 Double zinc ribbon; Region: DZR; pfam12773 480224008578 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 480224008579 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 480224008580 phosphopeptide binding site; other site 480224008581 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 480224008582 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 480224008583 phosphopeptide binding site; other site 480224008584 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 480224008585 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 480224008586 Walker A/P-loop; other site 480224008587 ATP binding site [chemical binding]; other site 480224008588 Q-loop/lid; other site 480224008589 ABC transporter signature motif; other site 480224008590 Walker B; other site 480224008591 D-loop; other site 480224008592 H-loop/switch region; other site 480224008593 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 480224008594 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 480224008595 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 480224008596 non-specific DNA binding site [nucleotide binding]; other site 480224008597 salt bridge; other site 480224008598 sequence-specific DNA binding site [nucleotide binding]; other site 480224008599 Cupin domain; Region: Cupin_2; pfam07883 480224008600 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 480224008601 Domain of unknown function DUF20; Region: UPF0118; pfam01594 480224008602 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 480224008603 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 480224008604 classical (c) SDRs; Region: SDR_c; cd05233 480224008605 NAD(P) binding site [chemical binding]; other site 480224008606 active site 480224008607 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 480224008608 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 480224008609 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224008610 S-adenosylmethionine binding site [chemical binding]; other site 480224008611 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 480224008612 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 480224008613 putative substrate binding site [chemical binding]; other site 480224008614 putative ATP binding site [chemical binding]; other site 480224008615 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 480224008616 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 480224008617 active site 480224008618 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 480224008619 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 480224008620 putative active site [active] 480224008621 metal binding site [ion binding]; metal-binding site 480224008622 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 480224008623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224008624 ATP binding site [chemical binding]; other site 480224008625 Mg2+ binding site [ion binding]; other site 480224008626 G-X-G motif; other site 480224008627 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 480224008628 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 480224008629 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 480224008630 Thioredoxin; Region: Thioredoxin_4; pfam13462 480224008631 H+ Antiporter protein; Region: 2A0121; TIGR00900 480224008632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 480224008633 putative substrate translocation pore; other site 480224008634 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 480224008635 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 480224008636 MarR family; Region: MarR_2; cl17246 480224008637 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 480224008638 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 480224008639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224008640 dimer interface [polypeptide binding]; other site 480224008641 conserved gate region; other site 480224008642 putative PBP binding loops; other site 480224008643 ABC-ATPase subunit interface; other site 480224008644 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 480224008645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224008646 dimer interface [polypeptide binding]; other site 480224008647 conserved gate region; other site 480224008648 putative PBP binding loops; other site 480224008649 ABC-ATPase subunit interface; other site 480224008650 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 480224008651 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 480224008652 dimer interface [polypeptide binding]; other site 480224008653 active site 480224008654 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 480224008655 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 480224008656 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 480224008657 metal ion-dependent adhesion site (MIDAS); other site 480224008658 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 480224008659 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 480224008660 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 480224008661 active site lid residues [active] 480224008662 substrate binding pocket [chemical binding]; other site 480224008663 catalytic residues [active] 480224008664 substrate-Mg2+ binding site; other site 480224008665 aspartate-rich region 1; other site 480224008666 aspartate-rich region 2; other site 480224008667 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 480224008668 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 480224008669 DNA binding residues [nucleotide binding] 480224008670 B12 binding domain; Region: B12-binding_2; pfam02607 480224008671 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 480224008672 B12 binding site [chemical binding]; other site 480224008673 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 480224008674 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 480224008675 NADP-binding site; other site 480224008676 homotetramer interface [polypeptide binding]; other site 480224008677 substrate binding site [chemical binding]; other site 480224008678 homodimer interface [polypeptide binding]; other site 480224008679 active site 480224008680 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 480224008681 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 480224008682 active site 480224008683 Substrate binding site; other site 480224008684 Mg++ binding site; other site 480224008685 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 480224008686 putative trimer interface [polypeptide binding]; other site 480224008687 putative CoA binding site [chemical binding]; other site 480224008688 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 480224008689 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 480224008690 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 480224008691 Ligand Binding Site [chemical binding]; other site 480224008692 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 480224008693 elongation factor G; Reviewed; Region: PRK12740 480224008694 G1 box; other site 480224008695 putative GEF interaction site [polypeptide binding]; other site 480224008696 GTP/Mg2+ binding site [chemical binding]; other site 480224008697 Switch I region; other site 480224008698 G2 box; other site 480224008699 G3 box; other site 480224008700 Switch II region; other site 480224008701 G4 box; other site 480224008702 G5 box; other site 480224008703 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 480224008704 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 480224008705 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 480224008706 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 480224008707 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 480224008708 active site 480224008709 HIGH motif; other site 480224008710 nucleotide binding site [chemical binding]; other site 480224008711 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 480224008712 active site 480224008713 KMSKS motif; other site 480224008714 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 480224008715 tRNA binding surface [nucleotide binding]; other site 480224008716 anticodon binding site; other site 480224008717 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 480224008718 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 480224008719 protein binding site [polypeptide binding]; other site 480224008720 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 480224008721 histidinol dehydrogenase; Region: hisD; TIGR00069 480224008722 NAD binding site [chemical binding]; other site 480224008723 dimerization interface [polypeptide binding]; other site 480224008724 product binding site; other site 480224008725 substrate binding site [chemical binding]; other site 480224008726 zinc binding site [ion binding]; other site 480224008727 catalytic residues [active] 480224008728 YGGT family; Region: YGGT; pfam02325 480224008729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 480224008730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224008731 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 480224008732 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 480224008733 active site 480224008734 hypothetical protein; Provisional; Region: PRK14678 480224008735 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 480224008736 ATP binding site [chemical binding]; other site 480224008737 putative Mg++ binding site [ion binding]; other site 480224008738 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 480224008739 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 480224008740 nucleotide binding region [chemical binding]; other site 480224008741 ATP-binding site [chemical binding]; other site 480224008742 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 480224008743 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 480224008744 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 480224008745 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 480224008746 Uncharacterized conserved protein [Function unknown]; Region: COG4938 480224008747 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 480224008748 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 480224008749 Protein of unknown function (DUF499); Region: DUF499; pfam04465 480224008750 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 480224008751 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 480224008752 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 480224008753 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 480224008754 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224008755 catalytic residue [active] 480224008756 Trm112p-like protein; Region: Trm112p; cl01066 480224008757 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 480224008758 active site 480224008759 Uncharacterized conserved protein [Function unknown]; Region: COG1432 480224008760 LabA_like proteins; Region: LabA_like; cd06167 480224008761 putative metal binding site [ion binding]; other site 480224008762 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 480224008763 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 480224008764 Probable Catalytic site; other site 480224008765 metal-binding site 480224008766 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 480224008767 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 480224008768 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 480224008769 Walker A/P-loop; other site 480224008770 ATP binding site [chemical binding]; other site 480224008771 Q-loop/lid; other site 480224008772 ABC transporter signature motif; other site 480224008773 Walker B; other site 480224008774 D-loop; other site 480224008775 H-loop/switch region; other site 480224008776 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 480224008777 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 480224008778 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 480224008779 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 480224008780 active site 480224008781 dimerization interface [polypeptide binding]; other site 480224008782 Radical SAM superfamily; Region: Radical_SAM; pfam04055 480224008783 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 480224008784 FeS/SAM binding site; other site 480224008785 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 480224008786 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 480224008787 Coenzyme A binding pocket [chemical binding]; other site 480224008788 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 480224008789 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 480224008790 ribonuclease Y; Region: RNase_Y; TIGR03319 480224008791 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 480224008792 Zn2+ binding site [ion binding]; other site 480224008793 Mg2+ binding site [ion binding]; other site 480224008794 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 480224008795 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 480224008796 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 480224008797 ligand binding site [chemical binding]; other site 480224008798 flexible hinge region; other site 480224008799 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 480224008800 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 480224008801 metal binding triad; other site 480224008802 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 480224008803 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 480224008804 active site 480224008805 catalytic site [active] 480224008806 substrate binding site [chemical binding]; other site 480224008807 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 480224008808 transmembrane helices; other site 480224008809 TrkA-C domain; Region: TrkA_C; pfam02080 480224008810 TrkA-C domain; Region: TrkA_C; pfam02080 480224008811 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 480224008812 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 480224008813 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 480224008814 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 480224008815 substrate binding [chemical binding]; other site 480224008816 active site 480224008817 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 480224008818 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 480224008819 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224008820 dimer interface [polypeptide binding]; other site 480224008821 conserved gate region; other site 480224008822 putative PBP binding loops; other site 480224008823 ABC-ATPase subunit interface; other site 480224008824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224008825 dimer interface [polypeptide binding]; other site 480224008826 conserved gate region; other site 480224008827 ABC-ATPase subunit interface; other site 480224008828 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 480224008829 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 480224008830 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 480224008831 Transcriptional regulators [Transcription]; Region: PurR; COG1609 480224008832 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 480224008833 DNA binding site [nucleotide binding] 480224008834 domain linker motif; other site 480224008835 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 480224008836 putative dimerization interface [polypeptide binding]; other site 480224008837 putative ligand binding site [chemical binding]; other site 480224008838 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 480224008839 ParB-like nuclease domain; Region: ParBc; pfam02195 480224008840 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 480224008841 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 480224008842 NAD(P) binding site [chemical binding]; other site 480224008843 active site 480224008844 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 480224008845 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 480224008846 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 480224008847 ring oligomerisation interface [polypeptide binding]; other site 480224008848 ATP/Mg binding site [chemical binding]; other site 480224008849 stacking interactions; other site 480224008850 hinge regions; other site 480224008851 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 480224008852 oligomerisation interface [polypeptide binding]; other site 480224008853 mobile loop; other site 480224008854 roof hairpin; other site 480224008855 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 480224008856 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349; Region: Frankia_peptide; pfam14407 480224008857 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 480224008858 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 480224008859 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 480224008860 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 480224008861 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 480224008862 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 480224008863 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 480224008864 active site 480224008865 substrate binding pocket [chemical binding]; other site 480224008866 dimer interface [polypeptide binding]; other site 480224008867 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 480224008868 putative metal binding site [ion binding]; other site 480224008869 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 480224008870 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224008871 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224008872 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224008873 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 480224008874 cyclase homology domain; Region: CHD; cd07302 480224008875 nucleotidyl binding site; other site 480224008876 metal binding site [ion binding]; metal-binding site 480224008877 dimer interface [polypeptide binding]; other site 480224008878 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 480224008879 dimerization interface [polypeptide binding]; other site 480224008880 GAF domain; Region: GAF; cl17456 480224008881 GAF domain; Region: GAF_2; pfam13185 480224008882 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 480224008883 PAS domain; Region: PAS; smart00091 480224008884 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224008885 dimer interface [polypeptide binding]; other site 480224008886 phosphorylation site [posttranslational modification] 480224008887 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224008888 ATP binding site [chemical binding]; other site 480224008889 Mg2+ binding site [ion binding]; other site 480224008890 G-X-G motif; other site 480224008891 Calx-beta domain; Region: Calx-beta; cl02522 480224008892 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 480224008893 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 480224008894 active site 480224008895 HIGH motif; other site 480224008896 nucleotide binding site [chemical binding]; other site 480224008897 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 480224008898 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 480224008899 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 480224008900 active site 480224008901 KMSKS motif; other site 480224008902 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 480224008903 tRNA binding surface [nucleotide binding]; other site 480224008904 Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264 480224008905 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 480224008906 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 480224008907 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 480224008908 dimerization interface [polypeptide binding]; other site 480224008909 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 480224008910 ATP binding site [chemical binding]; other site 480224008911 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 480224008912 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 480224008913 HupF/HypC family; Region: HupF_HypC; pfam01455 480224008914 NifU-like domain; Region: NifU; cl00484 480224008915 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 480224008916 iron-sulfur cluster [ion binding]; other site 480224008917 [2Fe-2S] cluster binding site [ion binding]; other site 480224008918 cysteinyl-tRNA synthetase; Provisional; Region: cysS; PRK14536 480224008919 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 480224008920 nickel binding site [ion binding]; other site 480224008921 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 480224008922 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 480224008923 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 480224008924 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 480224008925 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 480224008926 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 480224008927 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 480224008928 Protein of unknown function (DUF1641); Region: DUF1641; pfam07849 480224008929 NACHT domain; Region: NACHT; pfam05729 480224008930 Uncharacterized conserved protein [Function unknown]; Region: COG1262 480224008931 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 480224008932 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 480224008933 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 480224008934 generic binding surface I; other site 480224008935 generic binding surface II; other site 480224008936 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 480224008937 putative active site [active] 480224008938 putative catalytic site [active] 480224008939 putative Mg binding site IVb [ion binding]; other site 480224008940 putative phosphate binding site [ion binding]; other site 480224008941 putative DNA binding site [nucleotide binding]; other site 480224008942 putative Mg binding site IVa [ion binding]; other site 480224008943 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 480224008944 proposed catalytic triad [active] 480224008945 active site nucleophile [active] 480224008946 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 480224008947 proposed catalytic triad [active] 480224008948 active site nucleophile [active] 480224008949 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 480224008950 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 480224008951 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224008952 dimer interface [polypeptide binding]; other site 480224008953 conserved gate region; other site 480224008954 putative PBP binding loops; other site 480224008955 ABC-ATPase subunit interface; other site 480224008956 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 480224008957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224008958 dimer interface [polypeptide binding]; other site 480224008959 conserved gate region; other site 480224008960 putative PBP binding loops; other site 480224008961 ABC-ATPase subunit interface; other site 480224008962 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 480224008963 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 480224008964 peptide binding site [polypeptide binding]; other site 480224008965 dimer interface [polypeptide binding]; other site 480224008966 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 480224008967 proposed catalytic triad [active] 480224008968 active site nucleophile [active] 480224008969 Transcriptional regulators [Transcription]; Region: GntR; COG1802 480224008970 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 480224008971 DNA-binding site [nucleotide binding]; DNA binding site 480224008972 FCD domain; Region: FCD; pfam07729 480224008973 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 480224008974 catalytic residues [active] 480224008975 dimer interface [polypeptide binding]; other site 480224008976 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 480224008977 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 480224008978 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 480224008979 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 480224008980 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 480224008981 putative metal binding site [ion binding]; other site 480224008982 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 480224008983 active site 480224008984 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 480224008985 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 480224008986 DsrE/DsrF-like family; Region: DrsE; pfam02635 480224008987 Predicted permease [General function prediction only]; Region: COG2985 480224008988 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 480224008989 TrkA-C domain; Region: TrkA_C; pfam02080 480224008990 TrkA-C domain; Region: TrkA_C; pfam02080 480224008991 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 480224008992 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 480224008993 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 480224008994 cofactor binding site; other site 480224008995 metal binding site [ion binding]; metal-binding site 480224008996 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 480224008997 Bacterial Ig-like domain; Region: Big_5; pfam13205 480224008998 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 480224008999 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 480224009000 NAD(P) binding site [chemical binding]; other site 480224009001 active site 480224009002 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 480224009003 active site 480224009004 intersubunit interactions; other site 480224009005 catalytic residue [active] 480224009006 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 480224009007 active site 480224009008 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 480224009009 TPP-binding site [chemical binding]; other site 480224009010 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 480224009011 PYR/PP interface [polypeptide binding]; other site 480224009012 dimer interface [polypeptide binding]; other site 480224009013 TPP binding site [chemical binding]; other site 480224009014 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 480224009015 HAS barrel domain; Region: HAS-barrel; pfam09378 480224009016 Domain of unknown function DUF87; Region: DUF87; pfam01935 480224009017 AAA-like domain; Region: AAA_10; pfam12846 480224009018 Response regulator receiver domain; Region: Response_reg; pfam00072 480224009019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224009020 active site 480224009021 phosphorylation site [posttranslational modification] 480224009022 intermolecular recognition site; other site 480224009023 dimerization interface [polypeptide binding]; other site 480224009024 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 480224009025 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 480224009026 active site 480224009027 motif I; other site 480224009028 motif II; other site 480224009029 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 480224009030 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 480224009031 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 480224009032 NAD binding site [chemical binding]; other site 480224009033 substrate binding site [chemical binding]; other site 480224009034 catalytic Zn binding site [ion binding]; other site 480224009035 tetramer interface [polypeptide binding]; other site 480224009036 structural Zn binding site [ion binding]; other site 480224009037 Eukaryotic phosphomannomutase; Region: PMM; cl17107 480224009038 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 480224009039 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 480224009040 motif II; other site 480224009041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 480224009042 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 480224009043 Walker A motif; other site 480224009044 ATP binding site [chemical binding]; other site 480224009045 Walker B motif; other site 480224009046 arginine finger; other site 480224009047 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 480224009048 metal ion-dependent adhesion site (MIDAS); other site 480224009049 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 480224009050 Response regulator receiver domain; Region: Response_reg; pfam00072 480224009051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224009052 active site 480224009053 phosphorylation site [posttranslational modification] 480224009054 intermolecular recognition site; other site 480224009055 dimerization interface [polypeptide binding]; other site 480224009056 GAF domain; Region: GAF_2; pfam13185 480224009057 GAF domain; Region: GAF_3; pfam13492 480224009058 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224009059 dimer interface [polypeptide binding]; other site 480224009060 phosphorylation site [posttranslational modification] 480224009061 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224009062 ATP binding site [chemical binding]; other site 480224009063 Mg2+ binding site [ion binding]; other site 480224009064 G-X-G motif; other site 480224009065 Response regulator receiver domain; Region: Response_reg; pfam00072 480224009066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224009067 active site 480224009068 phosphorylation site [posttranslational modification] 480224009069 intermolecular recognition site; other site 480224009070 dimerization interface [polypeptide binding]; other site 480224009071 Response regulator receiver domain; Region: Response_reg; pfam00072 480224009072 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224009073 active site 480224009074 phosphorylation site [posttranslational modification] 480224009075 intermolecular recognition site; other site 480224009076 dimerization interface [polypeptide binding]; other site 480224009077 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 480224009078 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 480224009079 metal binding site [ion binding]; metal-binding site 480224009080 active site 480224009081 I-site; other site 480224009082 Clp protease; Region: CLP_protease; pfam00574 480224009083 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 480224009084 oligomer interface [polypeptide binding]; other site 480224009085 active site residues [active] 480224009086 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 480224009087 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 480224009088 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 480224009089 trmE is a tRNA modification GTPase; Region: trmE; cd04164 480224009090 G1 box; other site 480224009091 GTP/Mg2+ binding site [chemical binding]; other site 480224009092 Switch I region; other site 480224009093 G2 box; other site 480224009094 Switch II region; other site 480224009095 G3 box; other site 480224009096 G4 box; other site 480224009097 G5 box; other site 480224009098 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 480224009099 Phosphoglycerate kinase; Region: PGK; pfam00162 480224009100 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 480224009101 substrate binding site [chemical binding]; other site 480224009102 hinge regions; other site 480224009103 ADP binding site [chemical binding]; other site 480224009104 catalytic site [active] 480224009105 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 480224009106 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224009107 GAF domain; Region: GAF_3; pfam13492 480224009108 GAF domain; Region: GAF_2; pfam13185 480224009109 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 480224009110 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224009111 dimer interface [polypeptide binding]; other site 480224009112 phosphorylation site [posttranslational modification] 480224009113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224009114 ATP binding site [chemical binding]; other site 480224009115 Mg2+ binding site [ion binding]; other site 480224009116 G-X-G motif; other site 480224009117 SEC-C motif; Region: SEC-C; pfam02810 480224009118 Uncharacterized conserved protein [Function unknown]; Region: COG1262 480224009119 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 480224009120 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 480224009121 TPR repeat; Region: TPR_11; pfam13414 480224009122 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224009123 binding surface 480224009124 TPR motif; other site 480224009125 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224009126 binding surface 480224009127 TPR motif; other site 480224009128 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224009129 binding surface 480224009130 TPR motif; other site 480224009131 TPR repeat; Region: TPR_11; pfam13414 480224009132 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224009133 TPR motif; other site 480224009134 binding surface 480224009135 TPR repeat; Region: TPR_11; pfam13414 480224009136 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224009137 binding surface 480224009138 TPR motif; other site 480224009139 TPR repeat; Region: TPR_11; pfam13414 480224009140 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 480224009141 active site 480224009142 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 480224009143 metal ion-dependent adhesion site (MIDAS); other site 480224009144 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 480224009145 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 480224009146 ATP-grasp domain; Region: ATP-grasp_4; cl17255 480224009147 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 480224009148 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 480224009149 carboxyltransferase (CT) interaction site; other site 480224009150 biotinylation site [posttranslational modification]; other site 480224009151 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 480224009152 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 480224009153 Sortase family; Region: Sortase; pfam04203 480224009154 active site 480224009155 catalytic site [active] 480224009156 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 480224009157 Methyltransferase domain; Region: Methyltransf_26; pfam13659 480224009158 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 480224009159 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 480224009160 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 480224009161 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 480224009162 metal binding site [ion binding]; metal-binding site 480224009163 active site 480224009164 lipoyl synthase; Provisional; Region: PRK05481 480224009165 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 480224009166 FeS/SAM binding site; other site 480224009167 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 480224009168 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 480224009169 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 480224009170 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 480224009171 tyrosine decarboxylase; Region: PLN02880 480224009172 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 480224009173 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 480224009174 catalytic residue [active] 480224009175 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 480224009176 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 480224009177 Queuine tRNA-ribosyltransferase; Region: TGT; pfam01702 480224009178 Ribosomal RNA methyltransferase (FmrO); Region: FmrO; pfam07091 480224009179 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 480224009180 Low molecular weight phosphatase family; Region: LMWPc; cd00115 480224009181 active site 480224009182 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 480224009183 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 480224009184 RNA binding site [nucleotide binding]; other site 480224009185 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 480224009186 RNA binding site [nucleotide binding]; other site 480224009187 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 480224009188 RNA binding site [nucleotide binding]; other site 480224009189 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 480224009190 RNA binding site [nucleotide binding]; other site 480224009191 ornithine cyclodeaminase; Validated; Region: PRK08618 480224009192 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 480224009193 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 480224009194 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 480224009195 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 480224009196 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 480224009197 cyanophycin synthetase; Provisional; Region: PRK14016 480224009198 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224009199 S-adenosylmethionine binding site [chemical binding]; other site 480224009200 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 480224009201 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 480224009202 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 480224009203 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 480224009204 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 480224009205 active site 480224009206 metal binding site [ion binding]; metal-binding site 480224009207 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 480224009208 Beta-propeller repeat; Region: SBBP; pfam06739 480224009209 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 480224009210 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 480224009211 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 480224009212 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 480224009213 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 480224009214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 480224009215 putative substrate translocation pore; other site 480224009216 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 480224009217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224009218 active site 480224009219 phosphorylation site [posttranslational modification] 480224009220 intermolecular recognition site; other site 480224009221 dimerization interface [polypeptide binding]; other site 480224009222 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 480224009223 DNA binding site [nucleotide binding] 480224009224 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 480224009225 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224009226 dimer interface [polypeptide binding]; other site 480224009227 phosphorylation site [posttranslational modification] 480224009228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224009229 ATP binding site [chemical binding]; other site 480224009230 Mg2+ binding site [ion binding]; other site 480224009231 G-X-G motif; other site 480224009232 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 480224009233 Transcriptional regulators [Transcription]; Region: FadR; COG2186 480224009234 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 480224009235 DNA-binding site [nucleotide binding]; DNA binding site 480224009236 FCD domain; Region: FCD; pfam07729 480224009237 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 480224009238 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 480224009239 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 480224009240 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 480224009241 active site 480224009242 NTP binding site [chemical binding]; other site 480224009243 metal binding triad [ion binding]; metal-binding site 480224009244 antibiotic binding site [chemical binding]; other site 480224009245 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 480224009246 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 480224009247 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 480224009248 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 480224009249 ADP-glucose phosphorylase; Region: PLN02643 480224009250 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 480224009251 nucleotide binding site/active site [active] 480224009252 HIT family signature motif; other site 480224009253 catalytic residue [active] 480224009254 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 480224009255 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224009256 ATP binding site [chemical binding]; other site 480224009257 Mg2+ binding site [ion binding]; other site 480224009258 G-X-G motif; other site 480224009259 CHAT domain; Region: CHAT; pfam12770 480224009260 SIR2-like domain; Region: SIR2_2; pfam13289 480224009261 AAA ATPase domain; Region: AAA_16; pfam13191 480224009262 FOG: WD40 repeat [General function prediction only]; Region: COG2319 480224009263 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 480224009264 structural tetrad; other site 480224009265 FOG: WD40 repeat [General function prediction only]; Region: COG2319 480224009266 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 480224009267 structural tetrad; other site 480224009268 Family description; Region: VCBS; pfam13517 480224009269 Family description; Region: VCBS; pfam13517 480224009270 Family description; Region: VCBS; pfam13517 480224009271 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 480224009272 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 480224009273 MarR family; Region: MarR; pfam01047 480224009274 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 480224009275 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 480224009276 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 480224009277 Walker A/P-loop; other site 480224009278 ATP binding site [chemical binding]; other site 480224009279 Q-loop/lid; other site 480224009280 ABC transporter signature motif; other site 480224009281 Walker B; other site 480224009282 D-loop; other site 480224009283 H-loop/switch region; other site 480224009284 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 480224009285 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 480224009286 Walker A motif; other site 480224009287 ATP binding site [chemical binding]; other site 480224009288 Walker B motif; other site 480224009289 arginine finger; other site 480224009290 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 480224009291 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 480224009292 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 480224009293 substrate binding site [chemical binding]; other site 480224009294 ATP binding site [chemical binding]; other site 480224009295 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 480224009296 active site 480224009297 catalytic site [active] 480224009298 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 480224009299 motif II; other site 480224009300 Peptidase S8 family domain, uncharacterized subfamily 3; Region: Peptidases_S8_3; cd04852 480224009301 active site 480224009302 catalytic triad [active] 480224009303 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 480224009304 PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from...; Region: PA_subtilisin_like; cd02120 480224009305 PA/protease or protease-like domain interface [polypeptide binding]; other site 480224009306 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 480224009307 catalytic residues [active] 480224009308 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 480224009309 oligomerisation interface [polypeptide binding]; other site 480224009310 mobile loop; other site 480224009311 roof hairpin; other site 480224009312 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 480224009313 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 480224009314 ring oligomerisation interface [polypeptide binding]; other site 480224009315 ATP/Mg binding site [chemical binding]; other site 480224009316 stacking interactions; other site 480224009317 hinge regions; other site 480224009318 elongation factor P; Validated; Region: PRK00529 480224009319 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 480224009320 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 480224009321 RNA binding site [nucleotide binding]; other site 480224009322 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 480224009323 RNA binding site [nucleotide binding]; other site 480224009324 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 480224009325 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 480224009326 NAD binding site [chemical binding]; other site 480224009327 ligand binding site [chemical binding]; other site 480224009328 catalytic site [active] 480224009329 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 480224009330 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 480224009331 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224009332 homodimer interface [polypeptide binding]; other site 480224009333 catalytic residue [active] 480224009334 Transposase IS200 like; Region: Y1_Tnp; cl00848 480224009335 DDE superfamily endonuclease; Region: DDE_5; cl17874 480224009336 isocitrate dehydrogenase; Validated; Region: PRK07362 480224009337 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 480224009338 FOG: CBS domain [General function prediction only]; Region: COG0517 480224009339 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 480224009340 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 480224009341 NADH dehydrogenase subunit B; Validated; Region: PRK06411 480224009342 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852 480224009343 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 480224009344 NADH dehydrogenase subunit D; Validated; Region: PRK06075 480224009345 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 480224009346 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 480224009347 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 480224009348 putative dimer interface [polypeptide binding]; other site 480224009349 [2Fe-2S] cluster binding site [ion binding]; other site 480224009350 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 480224009351 SLBB domain; Region: SLBB; pfam10531 480224009352 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 480224009353 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 480224009354 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 480224009355 catalytic loop [active] 480224009356 iron binding site [ion binding]; other site 480224009357 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 480224009358 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 480224009359 molybdopterin cofactor binding site; other site 480224009360 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 480224009361 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 480224009362 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 480224009363 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 480224009364 4Fe-4S binding domain; Region: Fer4; pfam00037 480224009365 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 480224009366 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 480224009367 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 480224009368 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 480224009369 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 480224009370 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 480224009371 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 480224009372 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 480224009373 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 480224009374 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 480224009375 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 480224009376 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 480224009377 NAD binding site [chemical binding]; other site 480224009378 homotetramer interface [polypeptide binding]; other site 480224009379 homodimer interface [polypeptide binding]; other site 480224009380 substrate binding site [chemical binding]; other site 480224009381 active site 480224009382 SurA N-terminal domain; Region: SurA_N_3; cl07813 480224009383 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 480224009384 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 480224009385 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 480224009386 DNA primase; Validated; Region: dnaG; PRK05667 480224009387 CHC2 zinc finger; Region: zf-CHC2; cl17510 480224009388 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 480224009389 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 480224009390 active site 480224009391 metal binding site [ion binding]; metal-binding site 480224009392 interdomain interaction site; other site 480224009393 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 480224009394 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 480224009395 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 480224009396 Zn2+ binding site [ion binding]; other site 480224009397 Mg2+ binding site [ion binding]; other site 480224009398 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 480224009399 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 480224009400 PQQ-like domain; Region: PQQ_2; pfam13360 480224009401 PLD-like domain; Region: PLDc_2; pfam13091 480224009402 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 480224009403 putative active site [active] 480224009404 catalytic site [active] 480224009405 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 480224009406 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 480224009407 ATP-binding site [chemical binding]; other site 480224009408 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 480224009409 endonuclease III; Region: ENDO3c; smart00478 480224009410 minor groove reading motif; other site 480224009411 helix-hairpin-helix signature motif; other site 480224009412 substrate binding pocket [chemical binding]; other site 480224009413 active site 480224009414 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 480224009415 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 480224009416 cofactor binding site; other site 480224009417 DNA binding site [nucleotide binding] 480224009418 substrate interaction site [chemical binding]; other site 480224009419 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 480224009420 active site 480224009421 nucleotide binding site [chemical binding]; other site 480224009422 HIGH motif; other site 480224009423 KMSKS motif; other site 480224009424 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 480224009425 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 480224009426 Walker A/P-loop; other site 480224009427 ATP binding site [chemical binding]; other site 480224009428 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 480224009429 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 480224009430 ABC transporter signature motif; other site 480224009431 Walker B; other site 480224009432 D-loop; other site 480224009433 H-loop/switch region; other site 480224009434 Recombination protein O N terminal; Region: RecO_N; pfam11967 480224009435 DNA repair protein RecO; Region: reco; TIGR00613 480224009436 Recombination protein O C terminal; Region: RecO_C; pfam02565 480224009437 Bacterial PH domain; Region: DUF304; pfam03703 480224009438 Short C-terminal domain; Region: SHOCT; pfam09851 480224009439 purine nucleoside phosphorylase; Provisional; Region: PRK08202 480224009440 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 480224009441 active site 480224009442 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 480224009443 putative active site [active] 480224009444 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 480224009445 active site 480224009446 Ap6A binding site [chemical binding]; other site 480224009447 nudix motif; other site 480224009448 metal binding site [ion binding]; metal-binding site 480224009449 Fructosamine kinase; Region: Fructosamin_kin; cl17579 480224009450 Phosphotransferase enzyme family; Region: APH; pfam01636 480224009451 PspC domain; Region: PspC; pfam04024 480224009452 NAD-dependent deacetylase; Provisional; Region: PRK00481 480224009453 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 480224009454 NAD+ binding site [chemical binding]; other site 480224009455 substrate binding site [chemical binding]; other site 480224009456 Zn binding site [ion binding]; other site 480224009457 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 480224009458 catalytic core [active] 480224009459 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 480224009460 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 480224009461 P loop; other site 480224009462 Nucleotide binding site [chemical binding]; other site 480224009463 DTAP/Switch II; other site 480224009464 Switch I; other site 480224009465 Arginase family; Region: Arginase; cd09989 480224009466 agmatinase; Region: agmatinase; TIGR01230 480224009467 active site 480224009468 Mn binding site [ion binding]; other site 480224009469 oligomer interface [polypeptide binding]; other site 480224009470 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14461 480224009471 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 480224009472 FeS/SAM binding site; other site 480224009473 histidyl-tRNA synthetase; Region: hisS; TIGR00442 480224009474 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 480224009475 dimer interface [polypeptide binding]; other site 480224009476 motif 1; other site 480224009477 active site 480224009478 motif 2; other site 480224009479 motif 3; other site 480224009480 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 480224009481 anticodon binding site; other site 480224009482 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 480224009483 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 480224009484 Predicted transcriptional regulator [Transcription]; Region: COG2378 480224009485 HTH domain; Region: HTH_11; cl17392 480224009486 WYL domain; Region: WYL; pfam13280 480224009487 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 480224009488 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 480224009489 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 480224009490 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693 480224009491 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 480224009492 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 480224009493 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 480224009494 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 480224009495 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 480224009496 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 480224009497 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 480224009498 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 480224009499 MutS domain I; Region: MutS_I; pfam01624 480224009500 MutS domain II; Region: MutS_II; pfam05188 480224009501 MutS domain III; Region: MutS_III; pfam05192 480224009502 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 480224009503 Walker A/P-loop; other site 480224009504 ATP binding site [chemical binding]; other site 480224009505 Q-loop/lid; other site 480224009506 ABC transporter signature motif; other site 480224009507 Walker B; other site 480224009508 D-loop; other site 480224009509 H-loop/switch region; other site 480224009510 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 480224009511 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 480224009512 active site 480224009513 Riboflavin kinase; Region: Flavokinase; pfam01687 480224009514 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 480224009515 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 480224009516 NAD(P) binding site [chemical binding]; other site 480224009517 active site 480224009518 adenylate kinase; Reviewed; Region: adk; PRK00279 480224009519 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 480224009520 AMP-binding site [chemical binding]; other site 480224009521 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 480224009522 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 480224009523 Catalytic domain of Protein Kinases; Region: PKc; cd00180 480224009524 active site 480224009525 ATP binding site [chemical binding]; other site 480224009526 substrate binding site [chemical binding]; other site 480224009527 activation loop (A-loop); other site 480224009528 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 480224009529 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 480224009530 binding surface 480224009531 TPR motif; other site 480224009532 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 480224009533 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224009534 binding surface 480224009535 TPR motif; other site 480224009536 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224009537 binding surface 480224009538 TPR motif; other site 480224009539 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224009540 binding surface 480224009541 TPR motif; other site 480224009542 Lamin Tail Domain; Region: LTD; pfam00932 480224009543 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 480224009544 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 480224009545 active site 480224009546 Substrate binding site; other site 480224009547 Mg++ binding site; other site 480224009548 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 480224009549 putative trimer interface [polypeptide binding]; other site 480224009550 putative CoA binding site [chemical binding]; other site 480224009551 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 480224009552 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 480224009553 HEAT repeats; Region: HEAT_2; pfam13646 480224009554 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 480224009555 RNA binding site [nucleotide binding]; other site 480224009556 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 480224009557 RNA binding site [nucleotide binding]; other site 480224009558 malonyl-CoA synthase; Validated; Region: PRK07514 480224009559 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 480224009560 acyl-activating enzyme (AAE) consensus motif; other site 480224009561 active site 480224009562 AMP binding site [chemical binding]; other site 480224009563 CoA binding site [chemical binding]; other site 480224009564 pyruvate phosphate dikinase; Provisional; Region: PRK09279 480224009565 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 480224009566 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 480224009567 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 480224009568 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 480224009569 Proline racemase; Region: Pro_racemase; pfam05544 480224009570 PEP synthetase regulatory protein; Provisional; Region: PRK05339 480224009571 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 480224009572 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 480224009573 nucleophilic elbow; other site 480224009574 catalytic triad; other site 480224009575 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 480224009576 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 480224009577 ligand binding site [chemical binding]; other site 480224009578 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 480224009579 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 480224009580 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 480224009581 NAD(P) binding site [chemical binding]; other site 480224009582 active site 480224009583 malate synthase A; Region: malate_syn_A; TIGR01344 480224009584 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 480224009585 active site 480224009586 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 480224009587 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 480224009588 GatB domain; Region: GatB_Yqey; smart00845 480224009589 Peroxidase, family 2; Region: Peroxidase_2; pfam01328 480224009590 Bacterial SH3 domain; Region: SH3_4; pfam06347 480224009591 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 480224009592 Double zinc ribbon; Region: DZR; pfam12773 480224009593 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 480224009594 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 480224009595 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 480224009596 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 480224009597 dimerization interface [polypeptide binding]; other site 480224009598 DPS ferroxidase diiron center [ion binding]; other site 480224009599 ion pore; other site 480224009600 MoxR-like ATPases [General function prediction only]; Region: COG0714 480224009601 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 480224009602 Walker B motif; other site 480224009603 arginine finger; other site 480224009604 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224009605 PAS domain; Region: PAS_9; pfam13426 480224009606 putative active site [active] 480224009607 heme pocket [chemical binding]; other site 480224009608 PAS domain S-box; Region: sensory_box; TIGR00229 480224009609 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224009610 putative active site [active] 480224009611 heme pocket [chemical binding]; other site 480224009612 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 480224009613 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224009614 putative active site [active] 480224009615 heme pocket [chemical binding]; other site 480224009616 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224009617 putative active site [active] 480224009618 heme pocket [chemical binding]; other site 480224009619 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 480224009620 metal binding site [ion binding]; metal-binding site 480224009621 active site 480224009622 I-site; other site 480224009623 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 480224009624 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 480224009625 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 480224009626 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 480224009627 active site 480224009628 phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324 480224009629 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 480224009630 Walker A/P-loop; other site 480224009631 ATP binding site [chemical binding]; other site 480224009632 Q-loop/lid; other site 480224009633 ABC transporter signature motif; other site 480224009634 Walker B; other site 480224009635 D-loop; other site 480224009636 H-loop/switch region; other site 480224009637 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 480224009638 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 480224009639 Walker A/P-loop; other site 480224009640 ATP binding site [chemical binding]; other site 480224009641 Q-loop/lid; other site 480224009642 ABC transporter signature motif; other site 480224009643 Walker B; other site 480224009644 D-loop; other site 480224009645 H-loop/switch region; other site 480224009646 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 480224009647 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 480224009648 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 480224009649 phosphonate C-P lyase system protein PhnH; Region: PhnH_redo; TIGR03292 480224009650 phosphonate C-P lyase system protein PhnG; Region: PhnG_redo; TIGR03293 480224009651 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 480224009652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224009653 dimer interface [polypeptide binding]; other site 480224009654 conserved gate region; other site 480224009655 ABC-ATPase subunit interface; other site 480224009656 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 480224009657 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 480224009658 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 480224009659 Walker A/P-loop; other site 480224009660 ATP binding site [chemical binding]; other site 480224009661 Q-loop/lid; other site 480224009662 ABC transporter signature motif; other site 480224009663 Walker B; other site 480224009664 D-loop; other site 480224009665 H-loop/switch region; other site 480224009666 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 480224009667 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 480224009668 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 480224009669 Coenzyme A binding pocket [chemical binding]; other site 480224009670 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 480224009671 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 480224009672 NADP binding site [chemical binding]; other site 480224009673 dimer interface [polypeptide binding]; other site 480224009674 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 480224009675 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 480224009676 hydrophobic ligand binding site; other site 480224009677 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 480224009678 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 480224009679 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 480224009680 active site 480224009681 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 480224009682 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 480224009683 active site 480224009684 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 480224009685 dimerization interface [polypeptide binding]; other site 480224009686 putative DNA binding site [nucleotide binding]; other site 480224009687 putative Zn2+ binding site [ion binding]; other site 480224009688 hypothetical protein; Provisional; Region: PRK08201 480224009689 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 480224009690 metal binding site [ion binding]; metal-binding site 480224009691 putative dimer interface [polypeptide binding]; other site 480224009692 DinB superfamily; Region: DinB_2; pfam12867 480224009693 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 480224009694 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 480224009695 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 480224009696 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 480224009697 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 480224009698 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224009699 ATP binding site [chemical binding]; other site 480224009700 Mg2+ binding site [ion binding]; other site 480224009701 G-X-G motif; other site 480224009702 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 480224009703 anchoring element; other site 480224009704 dimer interface [polypeptide binding]; other site 480224009705 ATP binding site [chemical binding]; other site 480224009706 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 480224009707 active site 480224009708 putative metal-binding site [ion binding]; other site 480224009709 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 480224009710 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 480224009711 NusA N-terminal domain; Region: NusA_N; pfam08529 480224009712 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 480224009713 RNA binding site [nucleotide binding]; other site 480224009714 homodimer interface [polypeptide binding]; other site 480224009715 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 480224009716 G-X-X-G motif; other site 480224009717 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 480224009718 G-X-X-G motif; other site 480224009719 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 480224009720 putative RNA binding cleft [nucleotide binding]; other site 480224009721 translation initiation factor IF-2; Region: IF-2; TIGR00487 480224009722 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 480224009723 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 480224009724 G1 box; other site 480224009725 putative GEF interaction site [polypeptide binding]; other site 480224009726 GTP/Mg2+ binding site [chemical binding]; other site 480224009727 Switch I region; other site 480224009728 G2 box; other site 480224009729 G3 box; other site 480224009730 Switch II region; other site 480224009731 G4 box; other site 480224009732 G5 box; other site 480224009733 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 480224009734 Translation-initiation factor 2; Region: IF-2; pfam11987 480224009735 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 480224009736 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 480224009737 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224009738 S-adenosylmethionine binding site [chemical binding]; other site 480224009739 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 480224009740 DHH family; Region: DHH; pfam01368 480224009741 DHHA1 domain; Region: DHHA1; pfam02272 480224009742 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 480224009743 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 480224009744 RNA binding site [nucleotide binding]; other site 480224009745 active site 480224009746 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 480224009747 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 480224009748 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 480224009749 Uncharacterized conserved protein [Function unknown]; Region: COG1284 480224009750 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 480224009751 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 480224009752 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 480224009753 S-adenosylmethionine synthetase; Validated; Region: PRK05250 480224009754 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 480224009755 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 480224009756 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 480224009757 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 480224009758 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 480224009759 homotetramer interface [polypeptide binding]; other site 480224009760 ligand binding site [chemical binding]; other site 480224009761 catalytic site [active] 480224009762 NAD binding site [chemical binding]; other site 480224009763 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 480224009764 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 480224009765 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 480224009766 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 480224009767 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 480224009768 substrate binding site [chemical binding]; other site 480224009769 ATP binding site [chemical binding]; other site 480224009770 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 480224009771 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 480224009772 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 480224009773 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 480224009774 Protein export membrane protein; Region: SecD_SecF; pfam02355 480224009775 protein-export membrane protein SecD; Region: secD; TIGR01129 480224009776 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 480224009777 Thioredoxin; Region: Thioredoxin_4; pfam13462 480224009778 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 480224009779 YceI-like domain; Region: YceI; pfam04264 480224009780 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 480224009781 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 480224009782 Walker A/P-loop; other site 480224009783 ATP binding site [chemical binding]; other site 480224009784 Q-loop/lid; other site 480224009785 ABC transporter signature motif; other site 480224009786 Walker B; other site 480224009787 D-loop; other site 480224009788 H-loop/switch region; other site 480224009789 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 480224009790 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 480224009791 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 480224009792 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 480224009793 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224009794 GAF domain; Region: GAF; pfam01590 480224009795 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224009796 GAF domain; Region: GAF; pfam01590 480224009797 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 480224009798 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224009799 dimer interface [polypeptide binding]; other site 480224009800 phosphorylation site [posttranslational modification] 480224009801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224009802 ATP binding site [chemical binding]; other site 480224009803 Mg2+ binding site [ion binding]; other site 480224009804 G-X-G motif; other site 480224009805 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 480224009806 dimer interface [polypeptide binding]; other site 480224009807 substrate binding site [chemical binding]; other site 480224009808 metal binding site [ion binding]; metal-binding site 480224009809 Rubrerythrin [Energy production and conversion]; Region: COG1592 480224009810 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 480224009811 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 480224009812 iron binding site [ion binding]; other site 480224009813 DinB superfamily; Region: DinB_2; pfam12867 480224009814 rod shape-determining protein MreB; Provisional; Region: PRK13930 480224009815 MreB and similar proteins; Region: MreB_like; cd10225 480224009816 nucleotide binding site [chemical binding]; other site 480224009817 Mg binding site [ion binding]; other site 480224009818 putative protofilament interaction site [polypeptide binding]; other site 480224009819 RodZ interaction site [polypeptide binding]; other site 480224009820 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735 480224009821 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 480224009822 gamma subunit interface [polypeptide binding]; other site 480224009823 epsilon subunit interface [polypeptide binding]; other site 480224009824 LBP interface [polypeptide binding]; other site 480224009825 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 480224009826 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 480224009827 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 480224009828 alpha subunit interaction interface [polypeptide binding]; other site 480224009829 Walker A motif; other site 480224009830 ATP binding site [chemical binding]; other site 480224009831 Walker B motif; other site 480224009832 inhibitor binding site; inhibition site 480224009833 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 480224009834 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 480224009835 core domain interface [polypeptide binding]; other site 480224009836 delta subunit interface [polypeptide binding]; other site 480224009837 epsilon subunit interface [polypeptide binding]; other site 480224009838 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 480224009839 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 480224009840 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 480224009841 beta subunit interaction interface [polypeptide binding]; other site 480224009842 Walker A motif; other site 480224009843 ATP binding site [chemical binding]; other site 480224009844 Walker B motif; other site 480224009845 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 480224009846 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 480224009847 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 480224009848 F0F1 ATP synthase subunit B; Provisional; Region: PRK14473 480224009849 ATP synthase subunit C; Region: ATP-synt_C; cl00466 480224009850 ATP synthase A chain; Region: ATP-synt_A; cl00413 480224009851 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 480224009852 Response regulator receiver domain; Region: Response_reg; pfam00072 480224009853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224009854 active site 480224009855 phosphorylation site [posttranslational modification] 480224009856 intermolecular recognition site; other site 480224009857 dimerization interface [polypeptide binding]; other site 480224009858 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 480224009859 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 480224009860 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 480224009861 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 480224009862 phosphate binding site [ion binding]; other site 480224009863 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 480224009864 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 480224009865 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 480224009866 carboxyltransferase (CT) interaction site; other site 480224009867 biotinylation site [posttranslational modification]; other site 480224009868 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 480224009869 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 480224009870 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 480224009871 Major Facilitator Superfamily; Region: MFS_1; pfam07690 480224009872 YhhN-like protein; Region: YhhN; cl01505 480224009873 PAS domain S-box; Region: sensory_box; TIGR00229 480224009874 PAS domain S-box; Region: sensory_box; TIGR00229 480224009875 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224009876 putative active site [active] 480224009877 heme pocket [chemical binding]; other site 480224009878 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 480224009879 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224009880 dimer interface [polypeptide binding]; other site 480224009881 phosphorylation site [posttranslational modification] 480224009882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224009883 ATP binding site [chemical binding]; other site 480224009884 Mg2+ binding site [ion binding]; other site 480224009885 G-X-G motif; other site 480224009886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224009887 Response regulator receiver domain; Region: Response_reg; pfam00072 480224009888 active site 480224009889 phosphorylation site [posttranslational modification] 480224009890 intermolecular recognition site; other site 480224009891 dimerization interface [polypeptide binding]; other site 480224009892 Response regulator receiver domain; Region: Response_reg; pfam00072 480224009893 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224009894 active site 480224009895 phosphorylation site [posttranslational modification] 480224009896 intermolecular recognition site; other site 480224009897 dimerization interface [polypeptide binding]; other site 480224009898 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 480224009899 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 480224009900 metal binding site [ion binding]; metal-binding site 480224009901 active site 480224009902 I-site; other site 480224009903 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 480224009904 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 480224009905 Walker A/P-loop; other site 480224009906 ATP binding site [chemical binding]; other site 480224009907 Q-loop/lid; other site 480224009908 ABC transporter signature motif; other site 480224009909 Walker B; other site 480224009910 D-loop; other site 480224009911 H-loop/switch region; other site 480224009912 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 480224009913 GTP-binding protein LepA; Provisional; Region: PRK05433 480224009914 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 480224009915 G1 box; other site 480224009916 putative GEF interaction site [polypeptide binding]; other site 480224009917 GTP/Mg2+ binding site [chemical binding]; other site 480224009918 Switch I region; other site 480224009919 G2 box; other site 480224009920 G3 box; other site 480224009921 Switch II region; other site 480224009922 G4 box; other site 480224009923 G5 box; other site 480224009924 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 480224009925 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 480224009926 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 480224009927 SurA N-terminal domain; Region: SurA_N; pfam09312 480224009928 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 480224009929 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 480224009930 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 480224009931 homodimer interface [polypeptide binding]; other site 480224009932 metal binding site [ion binding]; metal-binding site 480224009933 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 480224009934 homodimer interface [polypeptide binding]; other site 480224009935 active site 480224009936 putative chemical substrate binding site [chemical binding]; other site 480224009937 metal binding site [ion binding]; metal-binding site 480224009938 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 480224009939 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 480224009940 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 480224009941 active site 480224009942 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 480224009943 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 480224009944 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 480224009945 EamA-like transporter family; Region: EamA; pfam00892 480224009946 EamA-like transporter family; Region: EamA; pfam00892 480224009947 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 480224009948 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 480224009949 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 480224009950 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 480224009951 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 480224009952 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 480224009953 DNA binding residues [nucleotide binding] 480224009954 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 480224009955 active site 480224009956 catalytic site [active] 480224009957 substrate binding site [chemical binding]; other site 480224009958 WYL domain; Region: WYL; pfam13280 480224009959 Bacterial SH3 domain; Region: SH3_3; cl17532 480224009960 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 480224009961 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 480224009962 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 480224009963 LysE type translocator; Region: LysE; cl00565 480224009964 Thiamine pyrophosphokinase; Region: TPK; cd07995 480224009965 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 480224009966 active site 480224009967 dimerization interface [polypeptide binding]; other site 480224009968 thiamine binding site [chemical binding]; other site 480224009969 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 480224009970 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 480224009971 active site 480224009972 NTP binding site [chemical binding]; other site 480224009973 metal binding triad [ion binding]; metal-binding site 480224009974 antibiotic binding site [chemical binding]; other site 480224009975 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 480224009976 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 480224009977 active site 480224009978 HIGH motif; other site 480224009979 dimer interface [polypeptide binding]; other site 480224009980 KMSKS motif; other site 480224009981 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 480224009982 Bacterial transcriptional activator domain; Region: BTAD; smart01043 480224009983 AAA ATPase domain; Region: AAA_16; pfam13191 480224009984 Predicted ATPase [General function prediction only]; Region: COG3899 480224009985 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 480224009986 Response regulator receiver domain; Region: Response_reg; pfam00072 480224009987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224009988 active site 480224009989 phosphorylation site [posttranslational modification] 480224009990 intermolecular recognition site; other site 480224009991 dimerization interface [polypeptide binding]; other site 480224009992 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 480224009993 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 480224009994 metal binding site [ion binding]; metal-binding site 480224009995 active site 480224009996 I-site; other site 480224009997 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 480224009998 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 480224009999 ATP binding site [chemical binding]; other site 480224010000 Mg++ binding site [ion binding]; other site 480224010001 motif III; other site 480224010002 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 480224010003 nucleotide binding region [chemical binding]; other site 480224010004 ATP-binding site [chemical binding]; other site 480224010005 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 480224010006 RNA binding site [nucleotide binding]; other site 480224010007 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 480224010008 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 480224010009 Walker A motif; other site 480224010010 ATP binding site [chemical binding]; other site 480224010011 Walker B motif; other site 480224010012 arginine finger; other site 480224010013 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 480224010014 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 480224010015 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 480224010016 putative metal binding site; other site 480224010017 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 480224010018 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 480224010019 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 480224010020 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 480224010021 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 480224010022 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224010023 active site 480224010024 phosphorylation site [posttranslational modification] 480224010025 intermolecular recognition site; other site 480224010026 dimerization interface [polypeptide binding]; other site 480224010027 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 480224010028 Zn2+ binding site [ion binding]; other site 480224010029 Mg2+ binding site [ion binding]; other site 480224010030 short chain dehydrogenase; Provisional; Region: PRK06197 480224010031 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 480224010032 putative NAD(P) binding site [chemical binding]; other site 480224010033 active site 480224010034 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 480224010035 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 480224010036 HD domain; Region: HD_4; pfam13328 480224010037 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 480224010038 active site 480224010039 catalytic residues [active] 480224010040 metal binding site [ion binding]; metal-binding site 480224010041 EamA-like transporter family; Region: EamA; pfam00892 480224010042 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 480224010043 EamA-like transporter family; Region: EamA; pfam00892 480224010044 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 480224010045 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 480224010046 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 480224010047 ATP binding site [chemical binding]; other site 480224010048 putative Mg++ binding site [ion binding]; other site 480224010049 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 480224010050 nucleotide binding region [chemical binding]; other site 480224010051 ATP-binding site [chemical binding]; other site 480224010052 TRCF domain; Region: TRCF; pfam03461 480224010053 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 480224010054 Double zinc ribbon; Region: DZR; pfam12773 480224010055 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 480224010056 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 480224010057 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 480224010058 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224010059 dimer interface [polypeptide binding]; other site 480224010060 phosphorylation site [posttranslational modification] 480224010061 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224010062 ATP binding site [chemical binding]; other site 480224010063 Mg2+ binding site [ion binding]; other site 480224010064 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 480224010065 dimer interface [polypeptide binding]; other site 480224010066 ADP-ribose binding site [chemical binding]; other site 480224010067 active site 480224010068 nudix motif; other site 480224010069 metal binding site [ion binding]; metal-binding site 480224010070 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224010071 S-adenosylmethionine binding site [chemical binding]; other site 480224010072 Flagellin N-methylase; Region: FliB; cl00497 480224010073 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 480224010074 LrgA family; Region: LrgA; pfam03788 480224010075 GTP-binding protein Der; Reviewed; Region: PRK00093 480224010076 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 480224010077 G1 box; other site 480224010078 GTP/Mg2+ binding site [chemical binding]; other site 480224010079 Switch I region; other site 480224010080 G2 box; other site 480224010081 Switch II region; other site 480224010082 G3 box; other site 480224010083 G4 box; other site 480224010084 G5 box; other site 480224010085 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 480224010086 G1 box; other site 480224010087 GTP/Mg2+ binding site [chemical binding]; other site 480224010088 Switch I region; other site 480224010089 G2 box; other site 480224010090 G3 box; other site 480224010091 Switch II region; other site 480224010092 G4 box; other site 480224010093 G5 box; other site 480224010094 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 480224010095 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 480224010096 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 480224010097 active site 480224010098 catalytic site [active] 480224010099 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224010100 PAS domain; Region: PAS_9; pfam13426 480224010101 putative active site [active] 480224010102 heme pocket [chemical binding]; other site 480224010103 PAS fold; Region: PAS_3; pfam08447 480224010104 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224010105 putative active site [active] 480224010106 heme pocket [chemical binding]; other site 480224010107 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 480224010108 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224010109 dimer interface [polypeptide binding]; other site 480224010110 phosphorylation site [posttranslational modification] 480224010111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224010112 ATP binding site [chemical binding]; other site 480224010113 Mg2+ binding site [ion binding]; other site 480224010114 G-X-G motif; other site 480224010115 Response regulator receiver domain; Region: Response_reg; pfam00072 480224010116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224010117 active site 480224010118 phosphorylation site [posttranslational modification] 480224010119 intermolecular recognition site; other site 480224010120 dimerization interface [polypeptide binding]; other site 480224010121 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 480224010122 putative binding surface; other site 480224010123 active site 480224010124 intracellular protease, PfpI family; Region: PfpI; TIGR01382 480224010125 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 480224010126 conserved cys residue [active] 480224010127 Aerotolerance regulator N-terminal; Region: BatA; cl06567 480224010128 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 480224010129 metal ion-dependent adhesion site (MIDAS); other site 480224010130 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 480224010131 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 480224010132 metal ion-dependent adhesion site (MIDAS); other site 480224010133 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 480224010134 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 480224010135 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 480224010136 Part of AAA domain; Region: AAA_19; pfam13245 480224010137 Family description; Region: UvrD_C_2; pfam13538 480224010138 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 480224010139 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 480224010140 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 480224010141 DNA binding residues [nucleotide binding] 480224010142 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 480224010143 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 480224010144 ligand binding site [chemical binding]; other site 480224010145 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 480224010146 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 480224010147 ligand binding site [chemical binding]; other site 480224010148 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 480224010149 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 480224010150 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 480224010151 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 480224010152 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 480224010153 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 480224010154 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 480224010155 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 480224010156 putative dimer interface [polypeptide binding]; other site 480224010157 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 480224010158 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 480224010159 tetramer interface [polypeptide binding]; other site 480224010160 TPP-binding site [chemical binding]; other site 480224010161 heterodimer interface [polypeptide binding]; other site 480224010162 phosphorylation loop region [posttranslational modification] 480224010163 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 480224010164 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 480224010165 alpha subunit interface [polypeptide binding]; other site 480224010166 TPP binding site [chemical binding]; other site 480224010167 heterodimer interface [polypeptide binding]; other site 480224010168 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 480224010169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 480224010170 Major Facilitator Superfamily; Region: MFS_1; pfam07690 480224010171 putative substrate translocation pore; other site 480224010172 shikimate kinase; Reviewed; Region: aroK; PRK00131 480224010173 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 480224010174 ADP binding site [chemical binding]; other site 480224010175 magnesium binding site [ion binding]; other site 480224010176 putative shikimate binding site; other site 480224010177 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 480224010178 Clp amino terminal domain; Region: Clp_N; pfam02861 480224010179 Clp amino terminal domain; Region: Clp_N; pfam02861 480224010180 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 480224010181 Walker A motif; other site 480224010182 ATP binding site [chemical binding]; other site 480224010183 Walker B motif; other site 480224010184 arginine finger; other site 480224010185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 480224010186 Walker A motif; other site 480224010187 ATP binding site [chemical binding]; other site 480224010188 Walker B motif; other site 480224010189 arginine finger; other site 480224010190 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 480224010191 SLBB domain; Region: SLBB; pfam10531 480224010192 comEA protein; Region: comE; TIGR01259 480224010193 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 480224010194 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 480224010195 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 480224010196 domain interfaces; other site 480224010197 active site 480224010198 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 480224010199 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 480224010200 cobalamin binding residues [chemical binding]; other site 480224010201 putative BtuC binding residues; other site 480224010202 dimer interface [polypeptide binding]; other site 480224010203 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 480224010204 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 480224010205 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 480224010206 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 480224010207 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 480224010208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 480224010209 putative substrate translocation pore; other site 480224010210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 480224010211 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 480224010212 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 480224010213 nucleophile elbow; other site 480224010214 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 480224010215 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 480224010216 Cupin; Region: Cupin_6; pfam12852 480224010217 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 480224010218 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 480224010219 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 480224010220 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 480224010221 DNA binding residues [nucleotide binding] 480224010222 dimerization interface [polypeptide binding]; other site 480224010223 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 480224010224 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 480224010225 CAAX protease self-immunity; Region: Abi; pfam02517 480224010226 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 480224010227 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 480224010228 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 480224010229 Coenzyme A binding pocket [chemical binding]; other site 480224010230 Beta-lactamase; Region: Beta-lactamase; pfam00144 480224010231 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 480224010232 aconitate hydratase; Validated; Region: PRK09277 480224010233 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 480224010234 substrate binding site [chemical binding]; other site 480224010235 ligand binding site [chemical binding]; other site 480224010236 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 480224010237 substrate binding site [chemical binding]; other site 480224010238 magnesium chelatase subunit H; Provisional; Region: PRK12493 480224010239 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 480224010240 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 480224010241 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 480224010242 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 480224010243 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 480224010244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224010245 dimer interface [polypeptide binding]; other site 480224010246 putative PBP binding loops; other site 480224010247 ABC-ATPase subunit interface; other site 480224010248 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 480224010249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224010250 dimer interface [polypeptide binding]; other site 480224010251 conserved gate region; other site 480224010252 putative PBP binding loops; other site 480224010253 ABC-ATPase subunit interface; other site 480224010254 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 480224010255 Putative esterase; Region: Esterase; pfam00756 480224010256 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 480224010257 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 480224010258 FOG: WD40 repeat [General function prediction only]; Region: COG2319 480224010259 structural tetrad; other site 480224010260 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 480224010261 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 480224010262 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 480224010263 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 480224010264 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 480224010265 catalytic core [active] 480224010266 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 480224010267 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 480224010268 FAD binding site [chemical binding]; other site 480224010269 homotetramer interface [polypeptide binding]; other site 480224010270 substrate binding pocket [chemical binding]; other site 480224010271 catalytic base [active] 480224010272 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 480224010273 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 480224010274 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 480224010275 aromatic arch; other site 480224010276 DCoH dimer interaction site [polypeptide binding]; other site 480224010277 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 480224010278 DCoH tetramer interaction site [polypeptide binding]; other site 480224010279 substrate binding site [chemical binding]; other site 480224010280 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 480224010281 Thioredoxin; Region: Thioredoxin_4; pfam13462 480224010282 PUCC protein; Region: PUCC; pfam03209 480224010283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 480224010284 putative substrate translocation pore; other site 480224010285 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 480224010286 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 480224010287 DNA binding residues [nucleotide binding] 480224010288 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 480224010289 dimer interface [polypeptide binding]; other site 480224010290 FMN binding site [chemical binding]; other site 480224010291 NADPH bind site [chemical binding]; other site 480224010292 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 480224010293 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 480224010294 Walker A motif; other site 480224010295 ATP binding site [chemical binding]; other site 480224010296 Walker B motif; other site 480224010297 Peptidase family M41; Region: Peptidase_M41; pfam01434 480224010298 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 480224010299 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 480224010300 substrate binding pocket [chemical binding]; other site 480224010301 membrane-bound complex binding site; other site 480224010302 hinge residues; other site 480224010303 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 480224010304 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224010305 active site 480224010306 phosphorylation site [posttranslational modification] 480224010307 intermolecular recognition site; other site 480224010308 dimerization interface [polypeptide binding]; other site 480224010309 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 480224010310 DNA binding site [nucleotide binding] 480224010311 GAF domain; Region: GAF; pfam01590 480224010312 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224010313 GAF domain; Region: GAF_2; pfam13185 480224010314 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224010315 dimer interface [polypeptide binding]; other site 480224010316 phosphorylation site [posttranslational modification] 480224010317 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224010318 ATP binding site [chemical binding]; other site 480224010319 Mg2+ binding site [ion binding]; other site 480224010320 G-X-G motif; other site 480224010321 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 480224010322 active site 480224010323 Domain of unknown function DUF59; Region: DUF59; pfam01883 480224010324 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 480224010325 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 480224010326 NAD binding site [chemical binding]; other site 480224010327 substrate binding site [chemical binding]; other site 480224010328 catalytic Zn binding site [ion binding]; other site 480224010329 structural Zn binding site [ion binding]; other site 480224010330 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 480224010331 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 480224010332 Cna protein B-type domain; Region: Cna_B; pfam05738 480224010333 CARDB; Region: CARDB; pfam07705 480224010334 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 480224010335 Protein of unknown function DUF58; Region: DUF58; pfam01882 480224010336 4-alpha-glucanotransferase; Provisional; Region: PRK14508 480224010337 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 480224010338 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 480224010339 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 480224010340 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 480224010341 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 480224010342 DNA binding residues [nucleotide binding] 480224010343 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 480224010344 classical (c) SDRs; Region: SDR_c; cd05233 480224010345 NAD(P) binding site [chemical binding]; other site 480224010346 active site 480224010347 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 480224010348 PAS fold; Region: PAS_7; pfam12860 480224010349 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 480224010350 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 480224010351 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 480224010352 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 480224010353 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 480224010354 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 480224010355 Protein of unknown function DUF58; Region: DUF58; pfam01882 480224010356 von Willebrand factor type A domain; Region: VWA_2; pfam13519 480224010357 Beta-lactamase; Region: Beta-lactamase; pfam00144 480224010358 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 480224010359 Protein of unknown function, DUF393; Region: DUF393; pfam04134 480224010360 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 480224010361 putative active site [active] 480224010362 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 480224010363 nudix motif; other site 480224010364 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 480224010365 Glucokinase; Region: Glucokinase; pfam02685 480224010366 glucokinase, proteobacterial type; Region: glk; TIGR00749 480224010367 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 480224010368 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 480224010369 substrate binding site [chemical binding]; other site 480224010370 hexamer interface [polypeptide binding]; other site 480224010371 metal binding site [ion binding]; metal-binding site 480224010372 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 480224010373 tetramer (dimer of dimers) interface [polypeptide binding]; other site 480224010374 active site 480224010375 dimer interface [polypeptide binding]; other site 480224010376 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 480224010377 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 480224010378 PDZ domain associated with archaeal and bacterial M61 glycyl-aminopeptidases. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to...; Region: PDZ_glycyl_aminopeptidase; cd00990 480224010379 protein binding site [polypeptide binding]; other site 480224010380 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 480224010381 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 480224010382 This CD includes the respiratory arsenate reductase, As(V), catalytic subunit (ArrA) and other related proteins. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_Arsenate-R; cd02757 480224010383 putative [Fe4-S4] binding site [ion binding]; other site 480224010384 putative molybdopterin cofactor binding site [chemical binding]; other site 480224010385 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 480224010386 putative molybdopterin cofactor binding site; other site 480224010387 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 480224010388 4Fe-4S binding domain; Region: Fer4; pfam00037 480224010389 Predicted membrane protein [Function unknown]; Region: COG4881 480224010390 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 480224010391 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 480224010392 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 480224010393 putative dimerization interface [polypeptide binding]; other site 480224010394 Domain of unknown function (DUF427); Region: DUF427; pfam04248 480224010395 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 480224010396 DNA protecting protein DprA; Region: dprA; TIGR00732 480224010397 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 480224010398 nudix motif; other site 480224010399 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 480224010400 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 480224010401 HNH/ENDO VII superfamily nuclease with conserved GHE residues; Region: GH-E; pfam14410 480224010402 Bacterial self-protective colicin-like immunity; Region: Colicin_immun; pfam09204 480224010403 Colicin D; Region: Colicin_D; pfam11429 480224010404 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 480224010405 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 480224010406 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 480224010407 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 480224010408 dimer interface [polypeptide binding]; other site 480224010409 active site 480224010410 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 480224010411 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 480224010412 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 480224010413 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 480224010414 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 480224010415 substrate binding site [chemical binding]; other site 480224010416 oxyanion hole (OAH) forming residues; other site 480224010417 trimer interface [polypeptide binding]; other site 480224010418 Predicted transcriptional regulator [Transcription]; Region: COG1959 480224010419 Transcriptional regulator; Region: Rrf2; pfam02082 480224010420 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 480224010421 conjugal transfer protein TrbM; Provisional; Region: PRK13893 480224010422 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 480224010423 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 480224010424 catalytic residues [active] 480224010425 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 480224010426 active site 480224010427 NTP binding site [chemical binding]; other site 480224010428 metal binding triad [ion binding]; metal-binding site 480224010429 antibiotic binding site [chemical binding]; other site 480224010430 HEPN domain; Region: HEPN; pfam05168 480224010431 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 480224010432 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 480224010433 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224010434 GAF domain; Region: GAF_3; pfam13492 480224010435 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224010436 GAF domain; Region: GAF; pfam01590 480224010437 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224010438 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224010439 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 480224010440 Histidine kinase; Region: HisKA_3; pfam07730 480224010441 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224010442 ATP binding site [chemical binding]; other site 480224010443 Mg2+ binding site [ion binding]; other site 480224010444 G-X-G motif; other site 480224010445 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 480224010446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224010447 active site 480224010448 phosphorylation site [posttranslational modification] 480224010449 intermolecular recognition site; other site 480224010450 dimerization interface [polypeptide binding]; other site 480224010451 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 480224010452 DNA binding residues [nucleotide binding] 480224010453 dimerization interface [polypeptide binding]; other site 480224010454 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 480224010455 HEPN domain; Region: HEPN; cl00824 480224010456 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 480224010457 active site 480224010458 NTP binding site [chemical binding]; other site 480224010459 metal binding triad [ion binding]; metal-binding site 480224010460 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 480224010461 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 480224010462 substrate binding pocket [chemical binding]; other site 480224010463 membrane-bound complex binding site; other site 480224010464 hinge residues; other site 480224010465 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 480224010466 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 480224010467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224010468 putative PBP binding loops; other site 480224010469 dimer interface [polypeptide binding]; other site 480224010470 ABC-ATPase subunit interface; other site 480224010471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224010472 dimer interface [polypeptide binding]; other site 480224010473 conserved gate region; other site 480224010474 ABC-ATPase subunit interface; other site 480224010475 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 480224010476 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 480224010477 Walker A/P-loop; other site 480224010478 ATP binding site [chemical binding]; other site 480224010479 Q-loop/lid; other site 480224010480 ABC transporter signature motif; other site 480224010481 Walker B; other site 480224010482 D-loop; other site 480224010483 H-loop/switch region; other site 480224010484 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 480224010485 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 480224010486 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 480224010487 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 480224010488 Septum formation initiator; Region: DivIC; cl17659 480224010489 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 480224010490 cyclase homology domain; Region: CHD; cd07302 480224010491 nucleotidyl binding site; other site 480224010492 metal binding site [ion binding]; metal-binding site 480224010493 dimer interface [polypeptide binding]; other site 480224010494 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 480224010495 cyclase homology domain; Region: CHD; cd07302 480224010496 dimer interface [polypeptide binding]; other site 480224010497 nucleotidyl binding site; other site 480224010498 metal binding site [ion binding]; metal-binding site 480224010499 AAA ATPase domain; Region: AAA_16; pfam13191 480224010500 Predicted ATPase [General function prediction only]; Region: COG3899 480224010501 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 480224010502 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 480224010503 active site 480224010504 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 480224010505 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 480224010506 active site 480224010507 catalytic site [active] 480224010508 Helix-turn-helix domain; Region: HTH_17; pfam12728 480224010509 Trm112p-like protein; Region: Trm112p; pfam03966 480224010510 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224010511 S-adenosylmethionine binding site [chemical binding]; other site 480224010512 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 480224010513 active site 480224010514 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224010515 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 480224010516 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 480224010517 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 480224010518 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 480224010519 NAD(P) binding site [chemical binding]; other site 480224010520 active site 480224010521 O-Antigen ligase; Region: Wzy_C; pfam04932 480224010522 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 480224010523 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 480224010524 Bacterial sugar transferase; Region: Bac_transf; pfam02397 480224010525 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 480224010526 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 480224010527 active site 480224010528 dimer interface [polypeptide binding]; other site 480224010529 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 480224010530 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 480224010531 active site 480224010532 FMN binding site [chemical binding]; other site 480224010533 substrate binding site [chemical binding]; other site 480224010534 3Fe-4S cluster binding site [ion binding]; other site 480224010535 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 480224010536 domain interface; other site 480224010537 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 480224010538 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 480224010539 HSP70 interaction site [polypeptide binding]; other site 480224010540 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 480224010541 substrate binding site [polypeptide binding]; other site 480224010542 dimer interface [polypeptide binding]; other site 480224010543 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 480224010544 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 480224010545 active site 480224010546 metal binding site [ion binding]; metal-binding site 480224010547 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 480224010548 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 480224010549 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 480224010550 NAD(P) binding site [chemical binding]; other site 480224010551 homotetramer interface [polypeptide binding]; other site 480224010552 homodimer interface [polypeptide binding]; other site 480224010553 active site 480224010554 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 480224010555 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 480224010556 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 480224010557 CAAX protease self-immunity; Region: Abi; pfam02517 480224010558 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 480224010559 dimerization interface [polypeptide binding]; other site 480224010560 putative DNA binding site [nucleotide binding]; other site 480224010561 putative Zn2+ binding site [ion binding]; other site 480224010562 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 480224010563 Predicted integral membrane protein [Function unknown]; Region: COG5658 480224010564 SdpI/YhfL protein family; Region: SdpI; pfam13630 480224010565 CAAX protease self-immunity; Region: Abi; pfam02517 480224010566 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 480224010567 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 480224010568 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 480224010569 active site 480224010570 Zn binding site [ion binding]; other site 480224010571 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 480224010572 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 480224010573 Mechanosensitive ion channel; Region: MS_channel; pfam00924 480224010574 Protein of unknown function (DUF445); Region: DUF445; pfam04286 480224010575 methionine gamma-lyase; Validated; Region: PRK07049 480224010576 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 480224010577 homodimer interface [polypeptide binding]; other site 480224010578 substrate-cofactor binding pocket; other site 480224010579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224010580 catalytic residue [active] 480224010581 PAS domain; Region: PAS; smart00091 480224010582 PAS domain; Region: PAS_9; pfam13426 480224010583 putative active site [active] 480224010584 PAS fold; Region: PAS_4; pfam08448 480224010585 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 480224010586 tetramer interface [polypeptide binding]; other site 480224010587 dimer interface [polypeptide binding]; other site 480224010588 circadian clock protein KaiC; Reviewed; Region: PRK09302 480224010589 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 480224010590 Walker A motif; other site 480224010591 ATP binding site [chemical binding]; other site 480224010592 Walker B motif; other site 480224010593 recA bacterial DNA recombination protein; Region: RecA; cl17211 480224010594 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 480224010595 Walker A motif; other site 480224010596 ATP binding site [chemical binding]; other site 480224010597 Walker B motif; other site 480224010598 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 480224010599 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 480224010600 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 480224010601 metal binding site [ion binding]; metal-binding site 480224010602 active site 480224010603 I-site; other site 480224010604 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 480224010605 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 480224010606 classical (c) SDRs; Region: SDR_c; cd05233 480224010607 NAD(P) binding site [chemical binding]; other site 480224010608 active site 480224010609 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 480224010610 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 480224010611 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 480224010612 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 480224010613 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 480224010614 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 480224010615 homodimer interface [polypeptide binding]; other site 480224010616 NADP binding site [chemical binding]; other site 480224010617 substrate binding site [chemical binding]; other site 480224010618 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 480224010619 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 480224010620 ATP-grasp domain; Region: ATP-grasp_4; cl17255 480224010621 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 480224010622 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 480224010623 Coenzyme A binding pocket [chemical binding]; other site 480224010624 poly(hydroxyalkanoate) granule-associated protein; Region: PHA_granule_1; TIGR01837 480224010625 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 480224010626 Uncharacterized conserved protein [Function unknown]; Region: COG3937 480224010627 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 480224010628 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 480224010629 nucleophile elbow; other site 480224010630 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 480224010631 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224010632 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 480224010633 Catalytic domain of Protein Kinases; Region: PKc; cd00180 480224010634 active site 480224010635 ATP binding site [chemical binding]; other site 480224010636 substrate binding site [chemical binding]; other site 480224010637 activation loop (A-loop); other site 480224010638 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 480224010639 FOG: WD40 repeat [General function prediction only]; Region: COG2319 480224010640 structural tetrad; other site 480224010641 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 480224010642 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 480224010643 Cysteine-rich domain; Region: CCG; pfam02754 480224010644 Cysteine-rich domain; Region: CCG; pfam02754 480224010645 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 480224010646 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 480224010647 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 480224010648 glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377 480224010649 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 480224010650 glycerol kinase; Provisional; Region: glpK; PRK00047 480224010651 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 480224010652 N- and C-terminal domain interface [polypeptide binding]; other site 480224010653 active site 480224010654 MgATP binding site [chemical binding]; other site 480224010655 catalytic site [active] 480224010656 metal binding site [ion binding]; metal-binding site 480224010657 putative homotetramer interface [polypeptide binding]; other site 480224010658 glycerol binding site [chemical binding]; other site 480224010659 homodimer interface [polypeptide binding]; other site 480224010660 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 480224010661 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 480224010662 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 480224010663 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 480224010664 amphipathic channel; other site 480224010665 Asn-Pro-Ala signature motifs; other site 480224010666 Bacterial Ig-like domain; Region: Big_5; pfam13205 480224010667 Bacterial Ig-like domain; Region: Big_5; pfam13205 480224010668 Bacterial Ig-like domain; Region: Big_5; pfam13205 480224010669 Bacterial Ig-like domain; Region: Big_5; pfam13205 480224010670 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 480224010671 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 480224010672 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 480224010673 active site 480224010674 substrate binding site [chemical binding]; other site 480224010675 ATP binding site [chemical binding]; other site 480224010676 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 480224010677 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 480224010678 active site 480224010679 catalytic triad [active] 480224010680 oxyanion hole [active] 480224010681 drug efflux system protein MdtG; Provisional; Region: PRK09874 480224010682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 480224010683 putative substrate translocation pore; other site 480224010684 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 480224010685 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 480224010686 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 480224010687 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 480224010688 putative active site pocket [active] 480224010689 dimerization interface [polypeptide binding]; other site 480224010690 putative catalytic residue [active] 480224010691 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 480224010692 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 480224010693 putative active site; other site 480224010694 catalytic triad [active] 480224010695 putative dimer interface [polypeptide binding]; other site 480224010696 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 480224010697 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 480224010698 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 480224010699 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 480224010700 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 480224010701 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 480224010702 NAD(P) binding pocket [chemical binding]; other site 480224010703 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 480224010704 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 480224010705 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 480224010706 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 480224010707 Walker A/P-loop; other site 480224010708 ATP binding site [chemical binding]; other site 480224010709 Q-loop/lid; other site 480224010710 ABC transporter signature motif; other site 480224010711 Walker B; other site 480224010712 D-loop; other site 480224010713 H-loop/switch region; other site 480224010714 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 480224010715 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 480224010716 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 480224010717 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 480224010718 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 480224010719 CoenzymeA binding site [chemical binding]; other site 480224010720 subunit interaction site [polypeptide binding]; other site 480224010721 PHB binding site; other site 480224010722 Methyltransferase domain; Region: Methyltransf_31; pfam13847 480224010723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224010724 S-adenosylmethionine binding site [chemical binding]; other site 480224010725 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 480224010726 SmpB-tmRNA interface; other site 480224010727 O-Antigen ligase; Region: Wzy_C; cl04850 480224010728 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 480224010729 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 480224010730 putative active site [active] 480224010731 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 480224010732 dimer interface [polypeptide binding]; other site 480224010733 substrate binding site [chemical binding]; other site 480224010734 metal binding sites [ion binding]; metal-binding site 480224010735 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 480224010736 active site 480224010737 Ap6A binding site [chemical binding]; other site 480224010738 nudix motif; other site 480224010739 metal binding site [ion binding]; metal-binding site 480224010740 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 480224010741 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 480224010742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224010743 S-adenosylmethionine binding site [chemical binding]; other site 480224010744 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 480224010745 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 480224010746 metal binding site [ion binding]; metal-binding site 480224010747 dimer interface [polypeptide binding]; other site 480224010748 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 480224010749 classical (c) SDRs; Region: SDR_c; cd05233 480224010750 NAD(P) binding site [chemical binding]; other site 480224010751 active site 480224010752 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 480224010753 active site 480224010754 diiron metal binding site [ion binding]; other site 480224010755 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349; Region: Frankia_peptide; pfam14407 480224010756 cyclase homology domain; Region: CHD; cd07302 480224010757 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 480224010758 nucleotidyl binding site; other site 480224010759 metal binding site [ion binding]; metal-binding site 480224010760 dimer interface [polypeptide binding]; other site 480224010761 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 480224010762 cyclase homology domain; Region: CHD; cd07302 480224010763 nucleotidyl binding site; other site 480224010764 metal binding site [ion binding]; metal-binding site 480224010765 dimer interface [polypeptide binding]; other site 480224010766 AAA ATPase domain; Region: AAA_16; pfam13191 480224010767 Protein of unknown function (DUF1386); Region: DUF1386; pfam07138 480224010768 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224010769 TPR motif; other site 480224010770 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224010771 binding surface 480224010772 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224010773 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224010774 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224010775 binding surface 480224010776 TPR motif; other site 480224010777 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 480224010778 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 480224010779 FeS/SAM binding site; other site 480224010780 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 480224010781 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 480224010782 NAD(P) binding site [chemical binding]; other site 480224010783 catalytic residues [active] 480224010784 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 480224010785 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 480224010786 active site 480224010787 purine riboside binding site [chemical binding]; other site 480224010788 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 480224010789 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 480224010790 multifunctional aminopeptidase A; Provisional; Region: PRK00913 480224010791 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 480224010792 interface (dimer of trimers) [polypeptide binding]; other site 480224010793 Substrate-binding/catalytic site; other site 480224010794 Zn-binding sites [ion binding]; other site 480224010795 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224010796 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 480224010797 putative active site [active] 480224010798 heme pocket [chemical binding]; other site 480224010799 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224010800 putative active site [active] 480224010801 heme pocket [chemical binding]; other site 480224010802 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224010803 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224010804 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224010805 dimer interface [polypeptide binding]; other site 480224010806 phosphorylation site [posttranslational modification] 480224010807 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224010808 ATP binding site [chemical binding]; other site 480224010809 Mg2+ binding site [ion binding]; other site 480224010810 G-X-G motif; other site 480224010811 Response regulator receiver domain; Region: Response_reg; pfam00072 480224010812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224010813 active site 480224010814 phosphorylation site [posttranslational modification] 480224010815 intermolecular recognition site; other site 480224010816 dimerization interface [polypeptide binding]; other site 480224010817 OsmC-like protein; Region: OsmC; pfam02566 480224010818 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 480224010819 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 480224010820 CoA-transferase family III; Region: CoA_transf_3; pfam02515 480224010821 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 480224010822 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 480224010823 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 480224010824 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 480224010825 Coenzyme A binding pocket [chemical binding]; other site 480224010826 argininosuccinate lyase; Provisional; Region: PRK00855 480224010827 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 480224010828 active sites [active] 480224010829 tetramer interface [polypeptide binding]; other site 480224010830 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 480224010831 heterotetramer interface [polypeptide binding]; other site 480224010832 active site pocket [active] 480224010833 cleavage site 480224010834 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 480224010835 catalytic core [active] 480224010836 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 480224010837 AAA domain; Region: AAA_21; pfam13304 480224010838 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 480224010839 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 480224010840 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 480224010841 active site 480224010842 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 480224010843 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 480224010844 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 480224010845 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 480224010846 Double zinc ribbon; Region: DZR; pfam12773 480224010847 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 480224010848 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 480224010849 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 480224010850 phosphopeptide binding site; other site 480224010851 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 480224010852 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 480224010853 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 480224010854 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 480224010855 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 480224010856 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 480224010857 active site 480224010858 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 480224010859 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 480224010860 inhibitor-cofactor binding pocket; inhibition site 480224010861 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224010862 catalytic residue [active] 480224010863 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 480224010864 Coenzyme A binding pocket [chemical binding]; other site 480224010865 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 480224010866 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 480224010867 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 480224010868 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 480224010869 dimerization interface [polypeptide binding]; other site 480224010870 ATP binding site [chemical binding]; other site 480224010871 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 480224010872 dimerization interface [polypeptide binding]; other site 480224010873 ATP binding site [chemical binding]; other site 480224010874 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 480224010875 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 480224010876 magnesium chelatase, H subunit; Region: BchH; TIGR02025 480224010877 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 480224010878 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 480224010879 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 480224010880 MarR family; Region: MarR_2; pfam12802 480224010881 Major Facilitator Superfamily; Region: MFS_1; pfam07690 480224010882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 480224010883 putative substrate translocation pore; other site 480224010884 WYL domain; Region: WYL; pfam13280 480224010885 Catalytic domain of Protein Kinases; Region: PKc; cd00180 480224010886 active site 480224010887 ATP binding site [chemical binding]; other site 480224010888 substrate binding site [chemical binding]; other site 480224010889 activation loop (A-loop); other site 480224010890 Bacterial PH domain; Region: DUF304; cl01348 480224010891 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 480224010892 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224010893 active site 480224010894 phosphorylation site [posttranslational modification] 480224010895 intermolecular recognition site; other site 480224010896 dimerization interface [polypeptide binding]; other site 480224010897 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 480224010898 DNA binding residues [nucleotide binding] 480224010899 dimerization interface [polypeptide binding]; other site 480224010900 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 480224010901 GAF domain; Region: GAF; pfam01590 480224010902 GAF domain; Region: GAF_2; pfam13185 480224010903 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224010904 GAF domain; Region: GAF_3; pfam13492 480224010905 GAF domain; Region: GAF_3; pfam13492 480224010906 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 480224010907 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224010908 ATP binding site [chemical binding]; other site 480224010909 Mg2+ binding site [ion binding]; other site 480224010910 G-X-G motif; other site 480224010911 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 480224010912 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09702 480224010913 CRISPR-associated protein, TIGR02710 family; Region: TIGR02710 480224010914 WYL domain; Region: WYL; pfam13280 480224010915 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 480224010916 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 480224010917 RNA/DNA hybrid binding site [nucleotide binding]; other site 480224010918 active site 480224010919 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 480224010920 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 480224010921 putative NTP binding site [chemical binding]; other site 480224010922 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 480224010923 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 480224010924 putative active site [active] 480224010925 putative nucleic acid binding site [nucleotide binding]; other site 480224010926 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 480224010927 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 480224010928 WYL domain; Region: WYL; pfam13280 480224010929 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 480224010930 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 480224010931 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 480224010932 HSP70 interaction site [polypeptide binding]; other site 480224010933 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 480224010934 EVE domain; Region: EVE; pfam01878 480224010935 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 480224010936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224010937 active site 480224010938 phosphorylation site [posttranslational modification] 480224010939 intermolecular recognition site; other site 480224010940 dimerization interface [polypeptide binding]; other site 480224010941 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 480224010942 DNA binding site [nucleotide binding] 480224010943 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 480224010944 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 480224010945 dimerization interface [polypeptide binding]; other site 480224010946 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224010947 dimer interface [polypeptide binding]; other site 480224010948 phosphorylation site [posttranslational modification] 480224010949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224010950 ATP binding site [chemical binding]; other site 480224010951 Mg2+ binding site [ion binding]; other site 480224010952 G-X-G motif; other site 480224010953 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 480224010954 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 480224010955 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 480224010956 Na binding site [ion binding]; other site 480224010957 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 480224010958 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 480224010959 acyl-activating enzyme (AAE) consensus motif; other site 480224010960 putative AMP binding site [chemical binding]; other site 480224010961 putative active site [active] 480224010962 putative CoA binding site [chemical binding]; other site 480224010963 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 480224010964 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 480224010965 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 480224010966 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 480224010967 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 480224010968 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 480224010969 active site 480224010970 catalytic triad [active] 480224010971 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 480224010972 HlyD family secretion protein; Region: HlyD_3; pfam13437 480224010973 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 480224010974 Protein export membrane protein; Region: SecD_SecF; cl14618 480224010975 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 480224010976 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 480224010977 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 480224010978 nucleotide binding site [chemical binding]; other site 480224010979 N-acetyl-L-glutamate binding site [chemical binding]; other site 480224010980 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 480224010981 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 480224010982 ligand binding site [chemical binding]; other site 480224010983 flexible hinge region; other site 480224010984 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 480224010985 non-specific DNA interactions [nucleotide binding]; other site 480224010986 DNA binding site [nucleotide binding] 480224010987 sequence specific DNA binding site [nucleotide binding]; other site 480224010988 putative cAMP binding site [chemical binding]; other site 480224010989 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 480224010990 von Willebrand factor type A domain; Region: VWA_2; pfam13519 480224010991 metal ion-dependent adhesion site (MIDAS); other site 480224010992 Protein of unknown function (DUF402); Region: DUF402; pfam04167 480224010993 Protein of unknown function DUF58; Region: DUF58; pfam01882 480224010994 von Willebrand factor type A domain; Region: VWA_2; pfam13519 480224010995 metal ion-dependent adhesion site (MIDAS); other site 480224010996 MoxR-like ATPases [General function prediction only]; Region: COG0714 480224010997 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 480224010998 Walker A motif; other site 480224010999 ATP binding site [chemical binding]; other site 480224011000 Walker B motif; other site 480224011001 arginine finger; other site 480224011002 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 480224011003 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 480224011004 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 480224011005 AAA ATPase domain; Region: AAA_16; pfam13191 480224011006 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224011007 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224011008 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224011009 binding surface 480224011010 TPR motif; other site 480224011011 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224011012 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224011013 binding surface 480224011014 TPR motif; other site 480224011015 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224011016 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224011017 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224011018 binding surface 480224011019 TPR motif; other site 480224011020 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224011021 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224011022 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224011023 binding surface 480224011024 TPR motif; other site 480224011025 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224011026 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224011027 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224011028 binding surface 480224011029 TPR motif; other site 480224011030 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224011031 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224011032 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224011033 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224011034 binding surface 480224011035 TPR motif; other site 480224011036 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224011037 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224011038 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224011039 binding surface 480224011040 TPR motif; other site 480224011041 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224011042 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 480224011043 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 480224011044 acyl carrier protein; Provisional; Region: acpP; PRK00982 480224011045 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 480224011046 putative RNA binding site [nucleotide binding]; other site 480224011047 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 480224011048 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 480224011049 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 480224011050 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 480224011051 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 480224011052 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 480224011053 NAD(P) binding site [chemical binding]; other site 480224011054 homotetramer interface [polypeptide binding]; other site 480224011055 homodimer interface [polypeptide binding]; other site 480224011056 active site 480224011057 Restriction endonuclease; Region: Mrr_cat; pfam04471 480224011058 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 480224011059 ATP cone domain; Region: ATP-cone; pfam03477 480224011060 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 480224011061 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 480224011062 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 480224011063 Zn2+ binding site [ion binding]; other site 480224011064 Mg2+ binding site [ion binding]; other site 480224011065 UbiA prenyltransferase family; Region: UbiA; pfam01040 480224011066 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 480224011067 tocopherol phytyltransferase; Reviewed; Region: ubiA; PRK12887 480224011068 UbiA prenyltransferase family; Region: UbiA; pfam01040 480224011069 FOG: CBS domain [General function prediction only]; Region: COG0517 480224011070 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 480224011071 Histidine kinase; Region: HisKA_3; pfam07730 480224011072 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 480224011073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224011074 ATP binding site [chemical binding]; other site 480224011075 Mg2+ binding site [ion binding]; other site 480224011076 G-X-G motif; other site 480224011077 Predicted membrane protein [Function unknown]; Region: COG2311 480224011078 Protein of unknown function (DUF418); Region: DUF418; cl12135 480224011079 Protein of unknown function (DUF418); Region: DUF418; pfam04235 480224011080 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 480224011081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224011082 active site 480224011083 phosphorylation site [posttranslational modification] 480224011084 intermolecular recognition site; other site 480224011085 dimerization interface [polypeptide binding]; other site 480224011086 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 480224011087 DNA binding residues [nucleotide binding] 480224011088 dimerization interface [polypeptide binding]; other site 480224011089 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 480224011090 putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK05641 480224011091 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 480224011092 carboxyltransferase (CT) interaction site; other site 480224011093 biotinylation site [posttranslational modification]; other site 480224011094 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 480224011095 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 480224011096 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 480224011097 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 480224011098 CAAX protease self-immunity; Region: Abi; pfam02517 480224011099 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 480224011100 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 480224011101 active site 480224011102 Zn binding site [ion binding]; other site 480224011103 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 480224011104 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 480224011105 Methyltransferase domain; Region: Methyltransf_11; pfam08241 480224011106 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 480224011107 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 480224011108 putative glycosyl transferase; Provisional; Region: PRK10307 480224011109 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 480224011110 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 480224011111 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224011112 putative cation:proton antiport protein; Provisional; Region: PRK10669 480224011113 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 480224011114 TrkA-N domain; Region: TrkA_N; pfam02254 480224011115 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 480224011116 TrkA-C domain; Region: TrkA_C; pfam02080 480224011117 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 480224011118 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 480224011119 KIAA1161 is an uncharacterized Homo sapiens protein with a glycosyl hydrolase family 31 (GH31) domain that is homologous to the Escherichia coli YihQ glucosidase. Orthologs of KIA1161 are found in eukaryotes and prokaryotes. In bacteria, YihQ (along with...; Region: GH31_glucosidase_KIAA1161; cd06592 480224011120 putative active site [active] 480224011121 putative catalytic site [active] 480224011122 Transcriptional regulators [Transcription]; Region: PurR; COG1609 480224011123 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 480224011124 DNA binding site [nucleotide binding] 480224011125 domain linker motif; other site 480224011126 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 480224011127 dimerization interface [polypeptide binding]; other site 480224011128 ligand binding site [chemical binding]; other site 480224011129 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 480224011130 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 480224011131 Walker A/P-loop; other site 480224011132 ATP binding site [chemical binding]; other site 480224011133 Q-loop/lid; other site 480224011134 ABC transporter signature motif; other site 480224011135 Walker B; other site 480224011136 D-loop; other site 480224011137 H-loop/switch region; other site 480224011138 TOBE domain; Region: TOBE; cl01440 480224011139 TOBE domain; Region: TOBE; pfam03459 480224011140 Bpu10I restriction endonuclease; Region: RE_Bpu10I; pfam09549 480224011141 DNA methylase; Region: N6_N4_Mtase; cl17433 480224011142 Methyltransferase domain; Region: Methyltransf_26; pfam13659 480224011143 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 480224011144 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 480224011145 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 480224011146 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 480224011147 CHAT domain; Region: CHAT; cl02083 480224011148 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 480224011149 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 480224011150 dimerization interface [polypeptide binding]; other site 480224011151 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 480224011152 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 480224011153 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 480224011154 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 480224011155 Response regulator receiver domain; Region: Response_reg; pfam00072 480224011156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224011157 active site 480224011158 phosphorylation site [posttranslational modification] 480224011159 intermolecular recognition site; other site 480224011160 dimerization interface [polypeptide binding]; other site 480224011161 Helix-turn-helix domain; Region: HTH_25; pfam13413 480224011162 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 480224011163 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 480224011164 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 480224011165 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 480224011166 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 480224011167 active site 480224011168 HIGH motif; other site 480224011169 KMSKS motif; other site 480224011170 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 480224011171 tRNA binding surface [nucleotide binding]; other site 480224011172 anticodon binding site; other site 480224011173 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 480224011174 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 480224011175 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 480224011176 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 480224011177 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 480224011178 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 480224011179 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 480224011180 catalytic loop [active] 480224011181 iron binding site [ion binding]; other site 480224011182 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 480224011183 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 480224011184 putative hydrophobic ligand binding site [chemical binding]; other site 480224011185 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 480224011186 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 480224011187 homodimer interface [polypeptide binding]; other site 480224011188 substrate-cofactor binding pocket; other site 480224011189 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224011190 catalytic residue [active] 480224011191 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 480224011192 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 480224011193 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 480224011194 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224011195 dimer interface [polypeptide binding]; other site 480224011196 phosphorylation site [posttranslational modification] 480224011197 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224011198 ATP binding site [chemical binding]; other site 480224011199 Mg2+ binding site [ion binding]; other site 480224011200 G-X-G motif; other site 480224011201 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 480224011202 putative deacylase active site [active] 480224011203 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224011204 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 480224011205 Methyltransferase domain; Region: Methyltransf_23; pfam13489 480224011206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224011207 S-adenosylmethionine binding site [chemical binding]; other site 480224011208 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224011209 TPR repeat; Region: TPR_11; pfam13414 480224011210 TPR motif; other site 480224011211 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 480224011212 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 480224011213 Walker A motif; other site 480224011214 ATP binding site [chemical binding]; other site 480224011215 Walker B motif; other site 480224011216 arginine finger; other site 480224011217 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 480224011218 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 480224011219 Predicted transcriptional regulator [Transcription]; Region: COG2345 480224011220 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 480224011221 putative Zn2+ binding site [ion binding]; other site 480224011222 putative DNA binding site [nucleotide binding]; other site 480224011223 FeS assembly ATPase SufC; Region: sufC; TIGR01978 480224011224 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 480224011225 Walker A/P-loop; other site 480224011226 ATP binding site [chemical binding]; other site 480224011227 Q-loop/lid; other site 480224011228 ABC transporter signature motif; other site 480224011229 Walker B; other site 480224011230 D-loop; other site 480224011231 H-loop/switch region; other site 480224011232 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 480224011233 FeS assembly protein SufD; Region: sufD; TIGR01981 480224011234 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 480224011235 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 480224011236 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 480224011237 catalytic residue [active] 480224011238 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 480224011239 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 480224011240 trimerization site [polypeptide binding]; other site 480224011241 active site 480224011242 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 480224011243 FeS assembly protein SufB; Region: sufB; TIGR01980 480224011244 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 480224011245 [2Fe-2S] cluster binding site [ion binding]; other site 480224011246 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 480224011247 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 480224011248 active site residue [active] 480224011249 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 480224011250 active site residue [active] 480224011251 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 480224011252 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 480224011253 trimerization site [polypeptide binding]; other site 480224011254 active site 480224011255 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 480224011256 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 480224011257 dimer interface [polypeptide binding]; other site 480224011258 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224011259 catalytic residue [active] 480224011260 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 480224011261 MPN+ (JAMM) motif; other site 480224011262 Zinc-binding site [ion binding]; other site 480224011263 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 480224011264 MoaE interaction surface [polypeptide binding]; other site 480224011265 MoeB interaction surface [polypeptide binding]; other site 480224011266 thiocarboxylated glycine; other site 480224011267 hypothetical protein; Validated; Region: PRK07411 480224011268 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 480224011269 ATP binding site [chemical binding]; other site 480224011270 substrate interface [chemical binding]; other site 480224011271 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 480224011272 active site residue [active] 480224011273 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 480224011274 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 480224011275 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 480224011276 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 480224011277 dimerization interface [polypeptide binding]; other site 480224011278 putative DNA binding site [nucleotide binding]; other site 480224011279 putative Zn2+ binding site [ion binding]; other site 480224011280 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 480224011281 active site 480224011282 NTP binding site [chemical binding]; other site 480224011283 metal binding triad [ion binding]; metal-binding site 480224011284 antibiotic binding site [chemical binding]; other site 480224011285 CpXC protein; Region: CpXC; pfam14353 480224011286 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 480224011287 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 480224011288 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 480224011289 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 480224011290 lipoyl attachment site [posttranslational modification]; other site 480224011291 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 480224011292 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 480224011293 tetramer interface [polypeptide binding]; other site 480224011294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224011295 catalytic residue [active] 480224011296 active site 480224011297 substrate binding site [chemical binding]; other site 480224011298 Phosphotransferase enzyme family; Region: APH; pfam01636 480224011299 ATP binding site [chemical binding]; other site 480224011300 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 480224011301 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 480224011302 tetramer interface [polypeptide binding]; other site 480224011303 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224011304 catalytic residue [active] 480224011305 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 480224011306 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 480224011307 putative acyl-acceptor binding pocket; other site 480224011308 PAS domain S-box; Region: sensory_box; TIGR00229 480224011309 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 480224011310 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224011311 dimer interface [polypeptide binding]; other site 480224011312 phosphorylation site [posttranslational modification] 480224011313 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224011314 ATP binding site [chemical binding]; other site 480224011315 Mg2+ binding site [ion binding]; other site 480224011316 G-X-G motif; other site 480224011317 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 480224011318 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224011319 active site 480224011320 phosphorylation site [posttranslational modification] 480224011321 intermolecular recognition site; other site 480224011322 dimerization interface [polypeptide binding]; other site 480224011323 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 480224011324 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 480224011325 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 480224011326 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 480224011327 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 480224011328 DNA photolyase; Region: DNA_photolyase; pfam00875 480224011329 Aspartyl protease; Region: Asp_protease_2; pfam13650 480224011330 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 480224011331 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 480224011332 active site 480224011333 NTP binding site [chemical binding]; other site 480224011334 metal binding triad [ion binding]; metal-binding site 480224011335 antibiotic binding site [chemical binding]; other site 480224011336 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 480224011337 active site 480224011338 NTP binding site [chemical binding]; other site 480224011339 metal binding triad [ion binding]; metal-binding site 480224011340 antibiotic binding site [chemical binding]; other site 480224011341 ASRGL1_like domains, a subfamily of the L-Asparaginase type 2-like enzymes. The wider family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. The proenzymes undergo autoproteolytic cleavage before a threonine to generate alpha...; Region: ASRGL1_like; cd04702 480224011342 catalytic nucleophile [active] 480224011343 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 480224011344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 480224011345 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 480224011346 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 480224011347 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 480224011348 GAF domain; Region: GAF; pfam01590 480224011349 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 480224011350 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 480224011351 metal binding site [ion binding]; metal-binding site 480224011352 active site 480224011353 I-site; other site 480224011354 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 480224011355 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 480224011356 P-loop; other site 480224011357 Magnesium ion binding site [ion binding]; other site 480224011358 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 480224011359 Magnesium ion binding site [ion binding]; other site 480224011360 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 480224011361 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 480224011362 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 480224011363 cyclase homology domain; Region: CHD; cd07302 480224011364 nucleotidyl binding site; other site 480224011365 metal binding site [ion binding]; metal-binding site 480224011366 dimer interface [polypeptide binding]; other site 480224011367 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 480224011368 ApbE family; Region: ApbE; pfam02424 480224011369 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 480224011370 Haem-binding domain; Region: Haem_bd; pfam14376 480224011371 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 480224011372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224011373 active site 480224011374 phosphorylation site [posttranslational modification] 480224011375 intermolecular recognition site; other site 480224011376 dimerization interface [polypeptide binding]; other site 480224011377 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 480224011378 DNA binding site [nucleotide binding] 480224011379 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 480224011380 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224011381 dimer interface [polypeptide binding]; other site 480224011382 phosphorylation site [posttranslational modification] 480224011383 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 480224011384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224011385 ATP binding site [chemical binding]; other site 480224011386 Mg2+ binding site [ion binding]; other site 480224011387 G-X-G motif; other site 480224011388 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 480224011389 active site 480224011390 Ca binding site [ion binding]; other site 480224011391 catalytic site [active] 480224011392 Aamy_C domain; Region: Aamy_C; smart00632 480224011393 Alpha-amylase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. This domain is found in several bacterial and fungal alpha-amylases including the maltopentaose-forming amylases (G5-amylases). Most alpha-amylases have, in addition to the...; Region: CBM20_alpha_amylase; cd05808 480224011394 starch-binding site 2 [chemical binding]; other site 480224011395 starch-binding site 1 [chemical binding]; other site 480224011396 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 480224011397 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 480224011398 dimer interface [polypeptide binding]; other site 480224011399 active site 480224011400 CoA binding pocket [chemical binding]; other site 480224011401 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 480224011402 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 480224011403 NAD(P) binding site [chemical binding]; other site 480224011404 active site 480224011405 peptide synthase; Provisional; Region: PRK09274 480224011406 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910 480224011407 acyl-activating enzyme (AAE) consensus motif; other site 480224011408 putative AMP binding site [chemical binding]; other site 480224011409 putative active site [active] 480224011410 putative CoA binding site [chemical binding]; other site 480224011411 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 480224011412 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 480224011413 haloalkane dehalogenase; Provisional; Region: PRK03592 480224011414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224011415 active site 480224011416 phosphorylation site [posttranslational modification] 480224011417 intermolecular recognition site; other site 480224011418 PAS domain S-box; Region: sensory_box; TIGR00229 480224011419 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224011420 putative active site [active] 480224011421 heme pocket [chemical binding]; other site 480224011422 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 480224011423 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 480224011424 metal binding site [ion binding]; metal-binding site 480224011425 active site 480224011426 I-site; other site 480224011427 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 480224011428 Response regulator receiver domain; Region: Response_reg; pfam00072 480224011429 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224011430 active site 480224011431 phosphorylation site [posttranslational modification] 480224011432 intermolecular recognition site; other site 480224011433 dimerization interface [polypeptide binding]; other site 480224011434 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 480224011435 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224011436 putative active site [active] 480224011437 heme pocket [chemical binding]; other site 480224011438 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 480224011439 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224011440 putative active site [active] 480224011441 heme pocket [chemical binding]; other site 480224011442 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224011443 dimer interface [polypeptide binding]; other site 480224011444 phosphorylation site [posttranslational modification] 480224011445 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224011446 ATP binding site [chemical binding]; other site 480224011447 Mg2+ binding site [ion binding]; other site 480224011448 G-X-G motif; other site 480224011449 Protein of unknown function (DUF524); Region: DUF524; pfam04411 480224011450 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 480224011451 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 480224011452 oligomer interface [polypeptide binding]; other site 480224011453 metal binding site [ion binding]; metal-binding site 480224011454 metal binding site [ion binding]; metal-binding site 480224011455 putative Cl binding site [ion binding]; other site 480224011456 aspartate ring; other site 480224011457 basic sphincter; other site 480224011458 hydrophobic gate; other site 480224011459 periplasmic entrance; other site 480224011460 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 480224011461 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 480224011462 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 480224011463 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 480224011464 active site 480224011465 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 480224011466 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 480224011467 argininosuccinate synthase; Validated; Region: PRK05370 480224011468 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 480224011469 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 480224011470 Ligand binding site [chemical binding]; other site 480224011471 Electron transfer flavoprotein domain; Region: ETF; pfam01012 480224011472 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 480224011473 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 480224011474 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 480224011475 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 480224011476 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 480224011477 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 480224011478 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 480224011479 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 480224011480 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 480224011481 putative active site [active] 480224011482 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 480224011483 Uncharacterized conserved protein [Function unknown]; Region: COG5483 480224011484 Protein of unknown function, DUF488; Region: DUF488; pfam04343 480224011485 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 480224011486 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 480224011487 Probable Catalytic site; other site 480224011488 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 480224011489 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 480224011490 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 480224011491 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 480224011492 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 480224011493 acyl-coenzyme A oxidase; Region: PLN02526 480224011494 active site 480224011495 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 480224011496 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 480224011497 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 480224011498 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 480224011499 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 480224011500 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 480224011501 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 480224011502 enterobactin exporter EntS; Provisional; Region: PRK10489 480224011503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 480224011504 putative substrate translocation pore; other site 480224011505 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 480224011506 dimer interface [polypeptide binding]; other site 480224011507 catalytic triad [active] 480224011508 peroxidatic and resolving cysteines [active] 480224011509 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 480224011510 rRNA interaction site [nucleotide binding]; other site 480224011511 S8 interaction site; other site 480224011512 putative laminin-1 binding site; other site 480224011513 elongation factor Ts; Reviewed; Region: tsf; PRK12332 480224011514 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 480224011515 Elongation factor TS; Region: EF_TS; pfam00889 480224011516 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 480224011517 putative nucleotide binding site [chemical binding]; other site 480224011518 uridine monophosphate binding site [chemical binding]; other site 480224011519 homohexameric interface [polypeptide binding]; other site 480224011520 ribosome recycling factor; Reviewed; Region: frr; PRK00083 480224011521 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 480224011522 hinge region; other site 480224011523 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 480224011524 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 480224011525 catalytic residue [active] 480224011526 putative FPP diphosphate binding site; other site 480224011527 putative FPP binding hydrophobic cleft; other site 480224011528 dimer interface [polypeptide binding]; other site 480224011529 putative IPP diphosphate binding site; other site 480224011530 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 480224011531 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 480224011532 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 480224011533 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 480224011534 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 480224011535 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 480224011536 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 480224011537 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 480224011538 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 480224011539 protein binding site [polypeptide binding]; other site 480224011540 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 480224011541 putative substrate binding region [chemical binding]; other site 480224011542 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 480224011543 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 480224011544 BioY family; Region: BioY; pfam02632 480224011545 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 480224011546 active site residue [active] 480224011547 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 480224011548 carboxylate-amine ligase; Provisional; Region: PRK13515 480224011549 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 480224011550 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 480224011551 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 480224011552 FAD binding site [chemical binding]; other site 480224011553 homotetramer interface [polypeptide binding]; other site 480224011554 substrate binding pocket [chemical binding]; other site 480224011555 catalytic base [active] 480224011556 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 480224011557 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 480224011558 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 480224011559 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 480224011560 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 480224011561 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 480224011562 DNA binding residues [nucleotide binding] 480224011563 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 480224011564 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 480224011565 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 480224011566 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 480224011567 Major Facilitator Superfamily; Region: MFS_1; pfam07690 480224011568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 480224011569 putative substrate translocation pore; other site 480224011570 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 480224011571 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 480224011572 putative Zn2+ binding site [ion binding]; other site 480224011573 putative DNA binding site [nucleotide binding]; other site 480224011574 PBP superfamily domain; Region: PBP_like_2; cl17296 480224011575 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 480224011576 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 480224011577 dimerization interface [polypeptide binding]; other site 480224011578 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224011579 dimer interface [polypeptide binding]; other site 480224011580 phosphorylation site [posttranslational modification] 480224011581 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224011582 ATP binding site [chemical binding]; other site 480224011583 Mg2+ binding site [ion binding]; other site 480224011584 G-X-G motif; other site 480224011585 Response regulator receiver domain; Region: Response_reg; pfam00072 480224011586 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224011587 active site 480224011588 phosphorylation site [posttranslational modification] 480224011589 intermolecular recognition site; other site 480224011590 dimerization interface [polypeptide binding]; other site 480224011591 Trm112p-like protein; Region: Trm112p; pfam03966 480224011592 Methyltransferase domain; Region: Methyltransf_31; pfam13847 480224011593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224011594 S-adenosylmethionine binding site [chemical binding]; other site 480224011595 acylphosphatase; Provisional; Region: PRK14444 480224011596 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 480224011597 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 480224011598 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 480224011599 ligand binding site [chemical binding]; other site 480224011600 flexible hinge region; other site 480224011601 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 480224011602 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 480224011603 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 480224011604 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 480224011605 active site 480224011606 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 480224011607 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 480224011608 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 480224011609 Ligand Binding Site [chemical binding]; other site 480224011610 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 480224011611 Ligand Binding Site [chemical binding]; other site 480224011612 hypothetical protein; Reviewed; Region: PRK00024 480224011613 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 480224011614 MPN+ (JAMM) motif; other site 480224011615 Zinc-binding site [ion binding]; other site 480224011616 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 480224011617 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 480224011618 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 480224011619 active site 480224011620 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 480224011621 HIT family signature motif; other site 480224011622 catalytic residue [active] 480224011623 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 480224011624 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 480224011625 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 480224011626 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 480224011627 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 480224011628 Walker A/P-loop; other site 480224011629 ATP binding site [chemical binding]; other site 480224011630 Q-loop/lid; other site 480224011631 ABC transporter signature motif; other site 480224011632 Walker B; other site 480224011633 D-loop; other site 480224011634 H-loop/switch region; other site 480224011635 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 480224011636 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 480224011637 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 480224011638 TrkA-N domain; Region: TrkA_N; pfam02254 480224011639 TrkA-C domain; Region: TrkA_C; pfam02080 480224011640 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 480224011641 putative FMN binding site [chemical binding]; other site 480224011642 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 480224011643 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 480224011644 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 480224011645 CAAX protease self-immunity; Region: Abi; pfam02517 480224011646 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224011647 Bacterial transcriptional activator domain; Region: BTAD; smart01043 480224011648 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224011649 binding surface 480224011650 TPR motif; other site 480224011651 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 480224011652 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 480224011653 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 480224011654 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 480224011655 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 480224011656 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 480224011657 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 480224011658 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 480224011659 acyl-activating enzyme (AAE) consensus motif; other site 480224011660 putative AMP binding site [chemical binding]; other site 480224011661 putative active site [active] 480224011662 putative CoA binding site [chemical binding]; other site 480224011663 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 480224011664 PGAP1-like protein; Region: PGAP1; pfam07819 480224011665 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 480224011666 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 480224011667 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 480224011668 dimer interaction site [polypeptide binding]; other site 480224011669 substrate-binding tunnel; other site 480224011670 active site 480224011671 catalytic site [active] 480224011672 substrate binding site [chemical binding]; other site 480224011673 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 480224011674 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 480224011675 substrate binding site [chemical binding]; other site 480224011676 oxyanion hole (OAH) forming residues; other site 480224011677 trimer interface [polypeptide binding]; other site 480224011678 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 480224011679 active site 2 [active] 480224011680 active site 1 [active] 480224011681 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 480224011682 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 480224011683 putative ligand binding site [chemical binding]; other site 480224011684 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 480224011685 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 480224011686 Walker A/P-loop; other site 480224011687 ATP binding site [chemical binding]; other site 480224011688 Q-loop/lid; other site 480224011689 ABC transporter signature motif; other site 480224011690 Walker B; other site 480224011691 D-loop; other site 480224011692 H-loop/switch region; other site 480224011693 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 480224011694 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 480224011695 Walker A/P-loop; other site 480224011696 ATP binding site [chemical binding]; other site 480224011697 Q-loop/lid; other site 480224011698 ABC transporter signature motif; other site 480224011699 Walker B; other site 480224011700 D-loop; other site 480224011701 H-loop/switch region; other site 480224011702 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 480224011703 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 480224011704 TM-ABC transporter signature motif; other site 480224011705 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 480224011706 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 480224011707 TM-ABC transporter signature motif; other site 480224011708 DNA methylase; Region: N6_N4_Mtase; cl17433 480224011709 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 480224011710 DNA methylase; Region: N6_N4_Mtase; cl17433 480224011711 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 480224011712 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 480224011713 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 480224011714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 480224011715 intermolecular recognition site; other site 480224011716 active site 480224011717 dimerization interface [polypeptide binding]; other site 480224011718 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 480224011719 DNA binding site [nucleotide binding] 480224011720 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 480224011721 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 480224011722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224011723 S-adenosylmethionine binding site [chemical binding]; other site 480224011724 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 480224011725 active site 480224011726 homodimer interface [polypeptide binding]; other site 480224011727 homotetramer interface [polypeptide binding]; other site 480224011728 Methyltransferase domain; Region: Methyltransf_31; pfam13847 480224011729 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224011730 S-adenosylmethionine binding site [chemical binding]; other site 480224011731 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 480224011732 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 480224011733 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 480224011734 Ligand binding site; other site 480224011735 Putative Catalytic site; other site 480224011736 DXD motif; other site 480224011737 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 480224011738 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 480224011739 HEAT repeats; Region: HEAT_2; pfam13646 480224011740 Bacterial SH3 domain homologues; Region: SH3b; smart00287 480224011741 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 480224011742 Flavoprotein; Region: Flavoprotein; pfam02441 480224011743 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 480224011744 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 480224011745 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 480224011746 CoA binding domain; Region: CoA_binding; smart00881 480224011747 salicylate biosynthesis isochorismate synthase; Validated; Region: PRK07054 480224011748 chorismate binding enzyme; Region: Chorismate_bind; cl10555 480224011749 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 480224011750 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 480224011751 dimer interface [polypeptide binding]; other site 480224011752 tetramer interface [polypeptide binding]; other site 480224011753 PYR/PP interface [polypeptide binding]; other site 480224011754 TPP binding site [chemical binding]; other site 480224011755 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 480224011756 TPP-binding site; other site 480224011757 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 480224011758 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 480224011759 inhibitor-cofactor binding pocket; inhibition site 480224011760 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224011761 catalytic residue [active] 480224011762 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 480224011763 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 480224011764 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 480224011765 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 480224011766 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 480224011767 ATP-NAD kinase; Region: NAD_kinase; pfam01513 480224011768 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 480224011769 E3 interaction surface; other site 480224011770 lipoyl attachment site [posttranslational modification]; other site 480224011771 e3 binding domain; Region: E3_binding; pfam02817 480224011772 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 480224011773 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 480224011774 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 480224011775 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 480224011776 alpha subunit interface [polypeptide binding]; other site 480224011777 TPP binding site [chemical binding]; other site 480224011778 heterodimer interface [polypeptide binding]; other site 480224011779 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 480224011780 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 480224011781 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 480224011782 tetramer interface [polypeptide binding]; other site 480224011783 TPP-binding site [chemical binding]; other site 480224011784 heterodimer interface [polypeptide binding]; other site 480224011785 phosphorylation loop region [posttranslational modification] 480224011786 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 480224011787 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 480224011788 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 480224011789 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 480224011790 FeS/SAM binding site; other site 480224011791 bacteriochlorophyll 4-vinyl reductase; Region: BchJ; TIGR02019 480224011792 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 480224011793 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 480224011794 RNA binding surface [nucleotide binding]; other site 480224011795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 480224011796 S-adenosylmethionine binding site [chemical binding]; other site 480224011797 cobalt transport protein CbiM; Validated; Region: PRK06265 480224011798 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 480224011799 PDGLE domain; Region: PDGLE; pfam13190 480224011800 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 480224011801 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 480224011802 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 480224011803 Walker A/P-loop; other site 480224011804 ATP binding site [chemical binding]; other site 480224011805 Q-loop/lid; other site 480224011806 ABC transporter signature motif; other site 480224011807 Walker B; other site 480224011808 D-loop; other site 480224011809 H-loop/switch region; other site 480224011810 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 480224011811 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_16; cd04674 480224011812 nudix motif; other site 480224011813 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 480224011814 catalytic residues [active] 480224011815 dimer interface [polypeptide binding]; other site 480224011816 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 480224011817 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 480224011818 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 480224011819 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 480224011820 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 480224011821 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 480224011822 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 480224011823 GIY-YIG type nucleases (URI domain); Region: GIYc; smart00465 480224011824 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 480224011825 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 480224011826 galactokinase; Provisional; Region: PRK05101 480224011827 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 480224011828 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 480224011829 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 480224011830 hydroxyglutarate oxidase; Provisional; Region: PRK11728 480224011831 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 480224011832 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 480224011833 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 480224011834 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 480224011835 Walker A/P-loop; other site 480224011836 ATP binding site [chemical binding]; other site 480224011837 Q-loop/lid; other site 480224011838 ABC transporter signature motif; other site 480224011839 Walker B; other site 480224011840 D-loop; other site 480224011841 H-loop/switch region; other site 480224011842 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 480224011843 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 480224011844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224011845 dimer interface [polypeptide binding]; other site 480224011846 conserved gate region; other site 480224011847 putative PBP binding loops; other site 480224011848 ABC-ATPase subunit interface; other site 480224011849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224011850 dimer interface [polypeptide binding]; other site 480224011851 conserved gate region; other site 480224011852 putative PBP binding loops; other site 480224011853 ABC-ATPase subunit interface; other site 480224011854 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 480224011855 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 480224011856 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 480224011857 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 480224011858 MgtE intracellular N domain; Region: MgtE_N; smart00924 480224011859 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 480224011860 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 480224011861 Divalent cation transporter; Region: MgtE; pfam01769 480224011862 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 480224011863 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 480224011864 E3 interaction surface; other site 480224011865 lipoyl attachment site [posttranslational modification]; other site 480224011866 e3 binding domain; Region: E3_binding; pfam02817 480224011867 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 480224011868 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 480224011869 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 480224011870 TPP-binding site [chemical binding]; other site 480224011871 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 480224011872 dimer interface [polypeptide binding]; other site 480224011873 PYR/PP interface [polypeptide binding]; other site 480224011874 TPP binding site [chemical binding]; other site 480224011875 Predicted coiled-coil domain-containing protein (DUF2360); Region: DUF2360; pfam10152 480224011876 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 480224011877 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 480224011878 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 480224011879 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 480224011880 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 480224011881 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 480224011882 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 480224011883 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 480224011884 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 480224011885 homotrimer interaction site [polypeptide binding]; other site 480224011886 putative active site [active] 480224011887 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 480224011888 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 480224011889 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 480224011890 generic binding surface II; other site 480224011891 generic binding surface I; other site 480224011892 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 480224011893 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 480224011894 carboxyltransferase (CT) interaction site; other site 480224011895 biotinylation site [posttranslational modification]; other site 480224011896 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 480224011897 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 480224011898 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 480224011899 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 480224011900 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 480224011901 substrate binding pocket [chemical binding]; other site 480224011902 chain length determination region; other site 480224011903 substrate-Mg2+ binding site; other site 480224011904 catalytic residues [active] 480224011905 aspartate-rich region 1; other site 480224011906 active site lid residues [active] 480224011907 aspartate-rich region 2; other site 480224011908 RNA polymerase sigma factor; Provisional; Region: PRK12519 480224011909 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 480224011910 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 480224011911 DNA binding residues [nucleotide binding] 480224011912 putative anti-sigmaE protein; Provisional; Region: PRK13920 480224011913 DDE superfamily endonuclease; Region: DDE_5; pfam13546 480224011914 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 480224011915 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 480224011916 Predicted transcriptional regulators [Transcription]; Region: COG1378 480224011917 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 480224011918 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 480224011919 C-terminal domain interface [polypeptide binding]; other site 480224011920 sugar binding site [chemical binding]; other site 480224011921 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 480224011922 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 480224011923 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 480224011924 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 480224011925 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 480224011926 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 480224011927 active site 480224011928 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 480224011929 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 480224011930 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 480224011931 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 480224011932 active site 480224011933 motif I; other site 480224011934 motif II; other site 480224011935 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 480224011936 HlyD family secretion protein; Region: HlyD_3; pfam13437 480224011937 Chain length determinant protein; Region: Wzz; cl15801 480224011938 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 480224011939 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 480224011940 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 480224011941 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224011942 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 480224011943 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 480224011944 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 480224011945 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224011946 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 480224011947 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 480224011948 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 480224011949 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 480224011950 Probable Catalytic site; other site 480224011951 metal-binding site 480224011952 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 480224011953 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 480224011954 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 480224011955 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 480224011956 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 480224011957 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 480224011958 Probable Catalytic site; other site 480224011959 metal-binding site 480224011960 O-Antigen ligase; Region: Wzy_C; pfam04932 480224011961 BNR repeat-like domain; Region: BNR_2; pfam13088 480224011962 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 480224011963 Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250 480224011964 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 480224011965 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 480224011966 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 480224011967 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 480224011968 active site 480224011969 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 480224011970 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 480224011971 active site 480224011972 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 480224011973 active site 480224011974 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 480224011975 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 480224011976 active site 480224011977 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 480224011978 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 480224011979 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 480224011980 Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077 480224011981 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 480224011982 classical (c) SDRs; Region: SDR_c; cd05233 480224011983 NAD(P) binding site [chemical binding]; other site 480224011984 active site 480224011985 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 480224011986 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 480224011987 acyl-activating enzyme (AAE) consensus motif; other site 480224011988 active site 480224011989 AMP binding site [chemical binding]; other site 480224011990 CoA binding site [chemical binding]; other site 480224011991 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u7; cd10931 480224011992 putative active site [active] 480224011993 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 480224011994 putative trimer interface [polypeptide binding]; other site 480224011995 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 480224011996 putative CoA binding site [chemical binding]; other site 480224011997 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 480224011998 trimer interface [polypeptide binding]; other site 480224011999 active site 480224012000 substrate binding site [chemical binding]; other site 480224012001 CoA binding site [chemical binding]; other site 480224012002 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 480224012003 active site 480224012004 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 480224012005 homodimer interface [polypeptide binding]; other site 480224012006 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 480224012007 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 480224012008 putative trimer interface [polypeptide binding]; other site 480224012009 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 480224012010 trimer interface [polypeptide binding]; other site 480224012011 active site 480224012012 substrate binding site [chemical binding]; other site 480224012013 putative CoA binding site [chemical binding]; other site 480224012014 CoA binding site [chemical binding]; other site 480224012015 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 480224012016 Ligand binding site; other site 480224012017 Putative Catalytic site; other site 480224012018 DXD motif; other site 480224012019 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 480224012020 B12 binding site [chemical binding]; other site 480224012021 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 480224012022 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 480224012023 FeS/SAM binding site; other site 480224012024 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 480224012025 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 480224012026 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 480224012027 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 480224012028 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 480224012029 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 480224012030 Ligand binding site; other site 480224012031 Putative Catalytic site; other site 480224012032 DXD motif; other site 480224012033 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 480224012034 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 480224012035 dimer interface [polypeptide binding]; other site 480224012036 active site 480224012037 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 480224012038 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 480224012039 inhibitor-cofactor binding pocket; inhibition site 480224012040 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224012041 catalytic residue [active] 480224012042 hypothetical protein; Provisional; Region: PRK07233 480224012043 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 480224012044 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 480224012045 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 480224012046 Bacterial sugar transferase; Region: Bac_transf; pfam02397 480224012047 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 480224012048 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 480224012049 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 480224012050 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 480224012051 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 480224012052 acyl-activating enzyme (AAE) consensus motif; other site 480224012053 putative AMP binding site [chemical binding]; other site 480224012054 putative active site [active] 480224012055 putative CoA binding site [chemical binding]; other site 480224012056 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 480224012057 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 480224012058 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 480224012059 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224012060 PAS domain; Region: PAS_9; pfam13426 480224012061 putative active site [active] 480224012062 heme pocket [chemical binding]; other site 480224012063 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224012064 PAS domain; Region: PAS_9; pfam13426 480224012065 putative active site [active] 480224012066 heme pocket [chemical binding]; other site 480224012067 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224012068 PAS domain; Region: PAS_9; pfam13426 480224012069 putative active site [active] 480224012070 heme pocket [chemical binding]; other site 480224012071 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 480224012072 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224012073 phosphorylation site [posttranslational modification] 480224012074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224012075 ATP binding site [chemical binding]; other site 480224012076 Mg2+ binding site [ion binding]; other site 480224012077 G-X-G motif; other site 480224012078 Response regulator receiver domain; Region: Response_reg; pfam00072 480224012079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224012080 active site 480224012081 phosphorylation site [posttranslational modification] 480224012082 intermolecular recognition site; other site 480224012083 dimerization interface [polypeptide binding]; other site 480224012084 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 480224012085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224012086 active site 480224012087 phosphorylation site [posttranslational modification] 480224012088 intermolecular recognition site; other site 480224012089 dimerization interface [polypeptide binding]; other site 480224012090 Response regulator receiver domain; Region: Response_reg; pfam00072 480224012091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224012092 active site 480224012093 phosphorylation site [posttranslational modification] 480224012094 intermolecular recognition site; other site 480224012095 dimerization interface [polypeptide binding]; other site 480224012096 Hpt domain; Region: Hpt; pfam01627 480224012097 putative binding surface; other site 480224012098 active site 480224012099 response regulator PleD; Reviewed; Region: pleD; PRK09581 480224012100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224012101 active site 480224012102 phosphorylation site [posttranslational modification] 480224012103 intermolecular recognition site; other site 480224012104 dimerization interface [polypeptide binding]; other site 480224012105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224012106 active site 480224012107 phosphorylation site [posttranslational modification] 480224012108 intermolecular recognition site; other site 480224012109 dimerization interface [polypeptide binding]; other site 480224012110 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 480224012111 metal binding site [ion binding]; metal-binding site 480224012112 active site 480224012113 I-site; other site 480224012114 Response regulator receiver domain; Region: Response_reg; pfam00072 480224012115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224012116 active site 480224012117 phosphorylation site [posttranslational modification] 480224012118 intermolecular recognition site; other site 480224012119 dimerization interface [polypeptide binding]; other site 480224012120 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 480224012121 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 480224012122 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 480224012123 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 480224012124 active site 480224012125 metal binding site [ion binding]; metal-binding site 480224012126 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 480224012127 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 480224012128 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 480224012129 catalytic residue [active] 480224012130 Bacitracin resistance protein BacA; Region: BacA; pfam02673 480224012131 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 480224012132 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 480224012133 active site 480224012134 DNA binding site [nucleotide binding] 480224012135 Int/Topo IB signature motif; other site 480224012136 Chlide_reductase_Y : Y subunit of chlorophyllide (chlide) reductase (BchY). Chlide reductase participates in photosynthetic pigment synthesis playing a role in the conversion of chlorophylls(Chl) into bacteriochlorophylls (BChl). Chlide reductase...; Region: Chlide_reductase_Y; cd01980 480224012137 chlorophyllide reductase subunit Y; Region: BchY; TIGR02015 480224012138 Chlide_reductase_Z : Z subunit of chlorophyllide (chlide) reductase (BchZ). Chlide reductase participates in photosynthetic pigment synthesis playing a role in the conversion of chlorophylls(Chl) into bacteriochlorophylls (BChl). Chlide reductase...; Region: Chlide_reductase_Z; cd01982 480224012139 chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014 480224012140 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 480224012141 Survival protein SurE; Region: SurE; pfam01975 480224012142 Chloroflexus aurantiacus (Ca) citrate synthase (CS)_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). This group is...; Region: CaCS_like; cd06116 480224012143 dimer interface [polypeptide binding]; other site 480224012144 Citrate synthase; Region: Citrate_synt; pfam00285 480224012145 active site 480224012146 citrylCoA binding site [chemical binding]; other site 480224012147 oxalacetate/citrate binding site [chemical binding]; other site 480224012148 coenzyme A binding site [chemical binding]; other site 480224012149 catalytic triad [active] 480224012150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 480224012151 putative substrate translocation pore; other site 480224012152 Major Facilitator Superfamily; Region: MFS_1; pfam07690 480224012153 agmatinase; Region: agmatinase; TIGR01230 480224012154 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 480224012155 putative active site [active] 480224012156 putative metal binding site [ion binding]; other site 480224012157 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 480224012158 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 480224012159 phosphopeptide binding site; other site 480224012160 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 480224012161 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 480224012162 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 480224012163 metal ion-dependent adhesion site (MIDAS); other site 480224012164 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 480224012165 active site 480224012166 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 480224012167 Catalytic domain of Protein Kinases; Region: PKc; cd00180 480224012168 active site 480224012169 ATP binding site [chemical binding]; other site 480224012170 substrate binding site [chemical binding]; other site 480224012171 activation loop (A-loop); other site 480224012172 FOG: WD40-like repeat [Function unknown]; Region: COG1520 480224012173 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 480224012174 active site 480224012175 Trp docking motif [polypeptide binding]; other site 480224012176 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 480224012177 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 480224012178 nucleotide binding site [chemical binding]; other site 480224012179 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 480224012180 Bacterial transcriptional activator domain; Region: BTAD; smart01043 480224012181 AAA ATPase domain; Region: AAA_16; pfam13191 480224012182 Predicted ATPase [General function prediction only]; Region: COG3903 480224012183 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 480224012184 TPR motif; other site 480224012185 binding surface 480224012186 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224012187 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224012188 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224012189 binding surface 480224012190 TPR motif; other site 480224012191 Tetratricopeptide repeat; Region: TPR_12; pfam13424 480224012192 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224012193 binding surface 480224012194 TPR motif; other site 480224012195 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl09947 480224012196 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 480224012197 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 480224012198 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 480224012199 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 480224012200 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 480224012201 Domain of unknown function DUF21; Region: DUF21; pfam01595 480224012202 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 480224012203 Transporter associated domain; Region: CorC_HlyC; smart01091 480224012204 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 480224012205 triosephosphate isomerase; Provisional; Region: PRK14567 480224012206 substrate binding site [chemical binding]; other site 480224012207 dimer interface [polypeptide binding]; other site 480224012208 catalytic triad [active] 480224012209 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 480224012210 active site 480224012211 putative substrate binding region [chemical binding]; other site 480224012212 Major Facilitator Superfamily; Region: MFS_1; pfam07690 480224012213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 480224012214 putative substrate translocation pore; other site 480224012215 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 480224012216 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 480224012217 siderophore binding site; other site 480224012218 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 480224012219 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 480224012220 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 480224012221 ABC-ATPase subunit interface; other site 480224012222 dimer interface [polypeptide binding]; other site 480224012223 putative PBP binding regions; other site 480224012224 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 480224012225 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 480224012226 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 480224012227 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 480224012228 ABC-ATPase subunit interface; other site 480224012229 dimer interface [polypeptide binding]; other site 480224012230 putative PBP binding regions; other site 480224012231 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 480224012232 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 480224012233 Walker A/P-loop; other site 480224012234 ATP binding site [chemical binding]; other site 480224012235 Q-loop/lid; other site 480224012236 ABC transporter signature motif; other site 480224012237 Walker B; other site 480224012238 D-loop; other site 480224012239 H-loop/switch region; other site 480224012240 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 480224012241 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 480224012242 intersubunit interface [polypeptide binding]; other site 480224012243 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 480224012244 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 480224012245 siderophore binding site; other site 480224012246 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 480224012247 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 480224012248 siderophore binding site; other site 480224012249 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 480224012250 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 480224012251 active site 480224012252 catalytic tetrad [active] 480224012253 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; pfam10012 480224012254 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 480224012255 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 480224012256 catalytic Zn binding site [ion binding]; other site 480224012257 NAD(P) binding site [chemical binding]; other site 480224012258 structural Zn binding site [ion binding]; other site 480224012259 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 480224012260 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 480224012261 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 480224012262 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 480224012263 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 480224012264 primosomal protein N' Region: priA; TIGR00595 480224012265 ATP binding site [chemical binding]; other site 480224012266 putative Mg++ binding site [ion binding]; other site 480224012267 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 480224012268 5S rRNA interface [nucleotide binding]; other site 480224012269 CTC domain interface [polypeptide binding]; other site 480224012270 L16 interface [polypeptide binding]; other site 480224012271 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 480224012272 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 480224012273 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 480224012274 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 480224012275 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 480224012276 motif 1; other site 480224012277 active site 480224012278 motif 2; other site 480224012279 motif 3; other site 480224012280 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 480224012281 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 480224012282 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 480224012283 Coenzyme A binding pocket [chemical binding]; other site 480224012284 Protein of unknown function (DUF507); Region: DUF507; cl01112 480224012285 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 480224012286 putative metal binding residues [ion binding]; other site 480224012287 signature motif; other site 480224012288 dimer interface [polypeptide binding]; other site 480224012289 active site 480224012290 polyP binding site; other site 480224012291 substrate binding site [chemical binding]; other site 480224012292 acceptor-phosphate pocket; other site 480224012293 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 480224012294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 480224012295 active site 480224012296 phosphorylation site [posttranslational modification] 480224012297 intermolecular recognition site; other site 480224012298 dimerization interface [polypeptide binding]; other site 480224012299 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 480224012300 DNA binding site [nucleotide binding] 480224012301 two-component sensor protein; Provisional; Region: cpxA; PRK09470 480224012302 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 480224012303 dimerization interface [polypeptide binding]; other site 480224012304 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224012305 dimer interface [polypeptide binding]; other site 480224012306 phosphorylation site [posttranslational modification] 480224012307 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224012308 ATP binding site [chemical binding]; other site 480224012309 Mg2+ binding site [ion binding]; other site 480224012310 G-X-G motif; other site 480224012311 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 480224012312 Putative carbohydrate binding domain; Region: CBM_X; pfam06204 480224012313 Glycoside hydrolase family 94 N-terminal-like domain of uncharacterized function; Region: GH94N_like_4; cd11751 480224012314 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 480224012315 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 480224012316 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 480224012317 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 480224012318 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 480224012319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224012320 dimer interface [polypeptide binding]; other site 480224012321 conserved gate region; other site 480224012322 putative PBP binding loops; other site 480224012323 ABC-ATPase subunit interface; other site 480224012324 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 480224012325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224012326 dimer interface [polypeptide binding]; other site 480224012327 conserved gate region; other site 480224012328 putative PBP binding loops; other site 480224012329 ABC-ATPase subunit interface; other site 480224012330 NHL repeat; Region: NHL; pfam01436 480224012331 Tetratricopeptide repeat; Region: TPR_16; pfam13432 480224012332 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 480224012333 TPR motif; other site 480224012334 binding surface 480224012335 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 480224012336 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 480224012337 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 480224012338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 480224012339 dimer interface [polypeptide binding]; other site 480224012340 conserved gate region; other site 480224012341 putative PBP binding loops; other site 480224012342 ABC-ATPase subunit interface; other site 480224012343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 480224012344 Putative glucoamylase; Region: Glycoamylase; pfam10091 480224012345 Transcriptional regulators [Transcription]; Region: PurR; COG1609 480224012346 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 480224012347 DNA binding site [nucleotide binding] 480224012348 domain linker motif; other site 480224012349 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 480224012350 dimerization interface [polypeptide binding]; other site 480224012351 ligand binding site [chemical binding]; other site 480224012352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368 480224012353 Putative glucoamylase; Region: Glycoamylase; pfam10091 480224012354 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 480224012355 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 480224012356 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 480224012357 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 480224012358 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 480224012359 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 480224012360 TM-ABC transporter signature motif; other site 480224012361 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 480224012362 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 480224012363 Walker A/P-loop; other site 480224012364 ATP binding site [chemical binding]; other site 480224012365 Q-loop/lid; other site 480224012366 ABC transporter signature motif; other site 480224012367 Walker B; other site 480224012368 D-loop; other site 480224012369 H-loop/switch region; other site 480224012370 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 480224012371 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 480224012372 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 480224012373 MG2 domain; Region: A2M_N; pfam01835 480224012374 4-alpha-glucanotransferase; Provisional; Region: PRK14508 480224012375 recombination protein F; Reviewed; Region: recF; PRK00064 480224012376 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 480224012377 Walker A/P-loop; other site 480224012378 ATP binding site [chemical binding]; other site 480224012379 Q-loop/lid; other site 480224012380 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 480224012381 ABC transporter signature motif; other site 480224012382 Walker B; other site 480224012383 D-loop; other site 480224012384 H-loop/switch region; other site 480224012385 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 480224012386 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 480224012387 homotetramer interface [polypeptide binding]; other site 480224012388 FMN binding site [chemical binding]; other site 480224012389 homodimer contacts [polypeptide binding]; other site 480224012390 putative active site [active] 480224012391 putative substrate binding site [chemical binding]; other site 480224012392 PAS domain S-box; Region: sensory_box; TIGR00229 480224012393 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224012394 putative active site [active] 480224012395 heme pocket [chemical binding]; other site 480224012396 PAS domain S-box; Region: sensory_box; TIGR00229 480224012397 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224012398 putative active site [active] 480224012399 heme pocket [chemical binding]; other site 480224012400 PAS fold; Region: PAS_4; pfam08448 480224012401 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 480224012402 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 480224012403 putative active site [active] 480224012404 FAD dependent oxidoreductase; Region: DAO; pfam01266 480224012405 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 480224012406 Beta-lactamase; Region: Beta-lactamase; pfam00144 480224012407 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 480224012408 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 480224012409 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 480224012410 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 480224012411 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 480224012412 putative active site [active] 480224012413 putative metal binding site [ion binding]; other site 480224012414 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 480224012415 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 480224012416 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 480224012417 dimerization interface [polypeptide binding]; other site 480224012418 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 480224012419 dimer interface [polypeptide binding]; other site 480224012420 phosphorylation site [posttranslational modification] 480224012421 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 480224012422 ATP binding site [chemical binding]; other site 480224012423 Mg2+ binding site [ion binding]; other site 480224012424 G-X-G motif; other site 480224012425 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 480224012426 isocitrate lyase; Provisional; Region: PRK15063 480224012427 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 480224012428 tetramer interface [polypeptide binding]; other site 480224012429 active site 480224012430 Mg2+/Mn2+ binding site [ion binding]; other site 480224012431 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 480224012432 homodimer interface [polypeptide binding]; other site 480224012433 chemical substrate binding site [chemical binding]; other site 480224012434 oligomer interface [polypeptide binding]; other site 480224012435 metal binding site [ion binding]; metal-binding site 480224012436 threonine dehydratase; Provisional; Region: PRK08198 480224012437 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 480224012438 tetramer interface [polypeptide binding]; other site 480224012439 pyridoxal 5'-phosphate binding site [chemical binding]; other site 480224012440 catalytic residue [active] 480224012441 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 480224012442 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 480224012443 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 480224012444 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 480224012445 Protein of unknown function (DUF1641); Region: DUF1641; pfam07849 480224012446 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 480224012447 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 480224012448 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 480224012449 active site residue [active] 480224012450 Transcriptional regulator [Transcription]; Region: LysR; COG0583 480224012451 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 480224012452 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 480224012453 dimerization interface [polypeptide binding]; other site 480224012454 Putative zinc-finger; Region: zf-HC2; pfam13490 480224012455 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 480224012456 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 480224012457 Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO)-like family, N-terminal TRX-fold subdomain; composed of proteins with similarity to PfPDO, a redox active thermostable protein believed to be the archaeal counterpart of bacterial DsbA and...; Region: PfPDO_like_N; cd02975 480224012458 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 480224012459 catalytic residues [active] 480224012460 Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973 480224012461 catalytic residues [active] 480224012462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 480224012463 putative substrate translocation pore; other site 480224012464 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 480224012465 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 480224012466 TadE-like protein; Region: TadE; pfam07811 480224012467 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 480224012468 TadE-like protein; Region: TadE; pfam07811 480224012469 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 480224012470 von Willebrand factor type A domain; Region: VWA_2; pfam13519 480224012471 AAA domain; Region: AAA_33; pfam13671 480224012472 AAA domain; Region: AAA_17; pfam13207 480224012473 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 480224012474 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 480224012475 putative trimer interface [polypeptide binding]; other site 480224012476 putative active site [active] 480224012477 putative substrate binding site [chemical binding]; other site 480224012478 putative CoA binding site [chemical binding]; other site 480224012479 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596 480224012480 active site 480224012481 Zn binding site [ion binding]; other site 480224012482 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 480224012483 Protein of unknown function DUF58; Region: DUF58; pfam01882 480224012484 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 480224012485 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 480224012486 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 480224012487 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224012488 putative active site [active] 480224012489 heme pocket [chemical binding]; other site 480224012490 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 480224012491 putative active site [active] 480224012492 heme pocket [chemical binding]; other site 480224012493 GAF domain; Region: GAF; cl17456 480224012494 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 480224012495 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 480224012496 metal binding site [ion binding]; metal-binding site 480224012497 active site 480224012498 I-site; other site 480224012499 Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212 480224012500 Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212 480224012501 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 480224012502 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 480224012503 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 480224012504 substrate binding pocket [chemical binding]; other site 480224012505 dimer interface [polypeptide binding]; other site 480224012506 inhibitor binding site; inhibition site 480224012507 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 480224012508 B12 binding site [chemical binding]; other site 480224012509 cobalt ligand [ion binding]; other site 480224012510 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 480224012511 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 480224012512 PhoU domain; Region: PhoU; pfam01895 480224012513 PhoU domain; Region: PhoU; pfam01895 480224012514 Isochorismatase family; Region: Isochorismatase; pfam00857 480224012515 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 480224012516 catalytic triad [active] 480224012517 conserved cis-peptide bond; other site 480224012518 DNA topoisomerase I; Validated; Region: PRK06599 480224012519 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 480224012520 active site 480224012521 interdomain interaction site; other site 480224012522 putative metal-binding site [ion binding]; other site 480224012523 nucleotide binding site [chemical binding]; other site 480224012524 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 480224012525 domain I; other site 480224012526 DNA binding groove [nucleotide binding] 480224012527 phosphate binding site [ion binding]; other site 480224012528 domain II; other site 480224012529 domain III; other site 480224012530 nucleotide binding site [chemical binding]; other site 480224012531 catalytic site [active] 480224012532 domain IV; other site 480224012533 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 480224012534 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 480224012535 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 480224012536 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 480224012537 Ferritin-like domain; Region: Ferritin; pfam00210 480224012538 ferroxidase diiron center [ion binding]; other site 480224012539 Protein of unknown function (DUF3623); Region: DUF3623; cl11843 480224012540 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 480224012541 CoA binding domain; Region: CoA_binding_2; pfam13380 480224012542 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 480224012543 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 480224012544 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 480224012545 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 480224012546 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 480224012547 DRTGG domain; Region: DRTGG; pfam07085 480224012548 laccase, plant; Region: laccase; TIGR03389 480224012549 transcription-repair coupling factor (mfd); Region: mfd; TIGR00580 480224012550 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 480224012551 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 480224012552 quinone interaction residues [chemical binding]; other site 480224012553 active site 480224012554 catalytic residues [active] 480224012555 FMN binding site [chemical binding]; other site 480224012556 substrate binding site [chemical binding]; other site 480224012557 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 480224012558 active site 480224012559 dimer interface [polypeptide binding]; other site 480224012560 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 480224012561 active site 480224012562 Yip1 domain; Region: Yip1; pfam04893 480224012563 Yip1 domain; Region: Yip1; pfam04893 480224012564 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 480224012565 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 480224012566 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 480224012567 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 480224012568 DNA binding residues [nucleotide binding] 480224012569 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 480224012570 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 480224012571 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 480224012572 TM-ABC transporter signature motif; other site 480224012573 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079