-- dump date 20140619_041445 -- class Genbank::misc_feature -- table misc_feature_note -- id note 324602000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 324602000002 Cyclin-dependent kinase 5 activator protein; Region: CDK5_activator; pfam03261 324602000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602000004 Walker A motif; other site 324602000005 ATP binding site [chemical binding]; other site 324602000006 Walker B motif; other site 324602000007 arginine finger; other site 324602000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 324602000009 DnaA box-binding interface [nucleotide binding]; other site 324602000010 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 324602000011 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 324602000012 acyl-activating enzyme (AAE) consensus motif; other site 324602000013 putative AMP binding site [chemical binding]; other site 324602000014 putative active site [active] 324602000015 putative CoA binding site [chemical binding]; other site 324602000016 acetyl-CoA synthetase; Provisional; Region: PRK00174 324602000017 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 324602000018 active site 324602000019 CoA binding site [chemical binding]; other site 324602000020 acyl-activating enzyme (AAE) consensus motif; other site 324602000021 AMP binding site [chemical binding]; other site 324602000022 acetate binding site [chemical binding]; other site 324602000023 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 324602000024 Double zinc ribbon; Region: DZR; pfam12773 324602000025 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 324602000026 Catalytic domain of Protein Kinases; Region: PKc; cd00180 324602000027 active site 324602000028 ATP binding site [chemical binding]; other site 324602000029 substrate binding site [chemical binding]; other site 324602000030 activation loop (A-loop); other site 324602000031 GTPase Era; Reviewed; Region: era; PRK00089 324602000032 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 324602000033 G1 box; other site 324602000034 GTP/Mg2+ binding site [chemical binding]; other site 324602000035 Switch I region; other site 324602000036 G2 box; other site 324602000037 Switch II region; other site 324602000038 G3 box; other site 324602000039 G4 box; other site 324602000040 G5 box; other site 324602000041 KH domain; Region: KH_2; pfam07650 324602000042 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 324602000043 cell division topological specificity factor MinE; Provisional; Region: PRK13991 324602000044 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 324602000045 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 324602000046 P-loop; other site 324602000047 ADP binding residues [chemical binding]; other site 324602000048 Switch I; other site 324602000049 Switch II; other site 324602000050 septum formation inhibitor; Reviewed; Region: minC; PRK00513 324602000051 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 324602000052 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 324602000053 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 324602000054 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 324602000055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602000056 putative substrate translocation pore; other site 324602000057 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324602000058 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324602000059 dimerization interface [polypeptide binding]; other site 324602000060 putative DNA binding site [nucleotide binding]; other site 324602000061 putative Zn2+ binding site [ion binding]; other site 324602000062 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 324602000063 Predicted permeases [General function prediction only]; Region: COG0701 324602000064 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 324602000065 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 324602000066 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 324602000067 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 324602000068 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324602000069 dimerization interface [polypeptide binding]; other site 324602000070 Histidine kinase; Region: HisKA_3; pfam07730 324602000071 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602000072 ATP binding site [chemical binding]; other site 324602000073 Mg2+ binding site [ion binding]; other site 324602000074 G-X-G motif; other site 324602000075 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324602000076 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602000077 active site 324602000078 phosphorylation site [posttranslational modification] 324602000079 intermolecular recognition site; other site 324602000080 dimerization interface [polypeptide binding]; other site 324602000081 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324602000082 DNA binding residues [nucleotide binding] 324602000083 dimerization interface [polypeptide binding]; other site 324602000084 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 324602000085 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 324602000086 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 324602000087 tetrathionate reductase subunit A; Provisional; Region: PRK14991 324602000088 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 324602000089 molybdopterin cofactor binding site; other site 324602000090 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 324602000091 putative molybdopterin cofactor binding site; other site 324602000092 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 324602000093 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 324602000094 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 324602000095 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258 324602000096 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 324602000097 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl19388 324602000098 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 324602000099 putative active site [active] 324602000100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602000101 active site 324602000102 phosphorylation site [posttranslational modification] 324602000103 intermolecular recognition site; other site 324602000104 dimerization interface [polypeptide binding]; other site 324602000105 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324602000106 metal binding site [ion binding]; metal-binding site 324602000107 active site 324602000108 I-site; other site 324602000109 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242 324602000110 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 324602000111 putative NAD(P) binding site [chemical binding]; other site 324602000112 catalytic Zn binding site [ion binding]; other site 324602000113 structural Zn binding site [ion binding]; other site 324602000114 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 324602000115 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 324602000116 putative active site [active] 324602000117 substrate binding site [chemical binding]; other site 324602000118 putative cosubstrate binding site; other site 324602000119 catalytic site [active] 324602000120 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 324602000121 substrate binding site [chemical binding]; other site 324602000122 Bacterial SH3 domain; Region: SH3_3; pfam08239 324602000123 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 324602000124 putative acyl-acceptor binding pocket; other site 324602000125 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 324602000126 Uncharacterized conserved protein [Function unknown]; Region: COG1739 324602000127 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 324602000128 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 324602000129 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 324602000130 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 324602000131 B12 binding site [chemical binding]; other site 324602000132 cobalt ligand [ion binding]; other site 324602000133 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 324602000134 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 324602000135 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 324602000136 Walker A; other site 324602000137 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 324602000138 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 324602000139 active site 324602000140 substrate binding site [chemical binding]; other site 324602000141 metal binding site [ion binding]; metal-binding site 324602000142 ATP-grasp domain; Region: ATP-grasp_4; cl17255 324602000143 Circularly permuted ATP-grasp type 2; Region: CP_ATPgrasp_2; pfam14403 324602000144 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 324602000145 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324602000146 intersubunit interface [polypeptide binding]; other site 324602000147 Protein of unknown function, DUF547; Region: DUF547; pfam04784 324602000148 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB); Region: GRDB; cl19416 324602000149 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 324602000150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602000151 S-adenosylmethionine binding site [chemical binding]; other site 324602000152 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 324602000153 active site 324602000154 Uncharacterized conserved protein [Function unknown]; Region: COG1543 324602000155 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 324602000156 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 324602000157 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 324602000158 Catalytic domain of Protein Kinases; Region: PKc; cd00180 324602000159 active site 324602000160 ATP binding site [chemical binding]; other site 324602000161 substrate binding site [chemical binding]; other site 324602000162 activation loop (A-loop); other site 324602000163 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 324602000164 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 324602000165 phosphopeptide binding site; other site 324602000166 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602000167 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324602000168 DNA binding site [nucleotide binding] 324602000169 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 324602000170 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 324602000171 hinge; other site 324602000172 active site 324602000173 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 324602000174 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 324602000175 NAD binding site [chemical binding]; other site 324602000176 homodimer interface [polypeptide binding]; other site 324602000177 active site 324602000178 substrate binding site [chemical binding]; other site 324602000179 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 324602000180 Catalytic domain of Protein Kinases; Region: PKc; cd00180 324602000181 active site 324602000182 ATP binding site [chemical binding]; other site 324602000183 substrate binding site [chemical binding]; other site 324602000184 activation loop (A-loop); other site 324602000185 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 324602000186 Zn binding sites [ion binding]; other site 324602000187 MoxR-like ATPases [General function prediction only]; Region: COG0714 324602000188 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602000189 Walker A motif; other site 324602000190 ATP binding site [chemical binding]; other site 324602000191 Walker B motif; other site 324602000192 arginine finger; other site 324602000193 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 324602000194 FtsX-like permease family; Region: FtsX; pfam02687 324602000195 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 324602000196 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 324602000197 FtsX-like permease family; Region: FtsX; pfam02687 324602000198 Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221 324602000199 acyl-CoA binding pocket [chemical binding]; other site 324602000200 CoA binding site [chemical binding]; other site 324602000201 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 324602000202 AhpC/TSA family; Region: AhpC-TSA; pfam00578 324602000203 CRISPR-associated negative auto-regulator DevR/Csa2; Region: DevR; pfam01905 324602000204 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639 324602000205 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 324602000206 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 324602000207 Predicted transcriptional regulator [Transcription]; Region: COG2378 324602000208 WYL domain; Region: WYL; pfam13280 324602000209 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 324602000210 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cl18200 324602000211 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324602000212 Uncharacterized conserved protein [Function unknown]; Region: COG3937 324602000213 CHAT domain; Region: CHAT; pfam12770 324602000214 colanic acid exporter; Provisional; Region: PRK10459 324602000215 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 324602000216 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 324602000217 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602000218 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324602000219 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 324602000220 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 324602000221 Probable Catalytic site; other site 324602000222 metal-binding site 324602000223 Right handed beta helix region; Region: Beta_helix; pfam13229 324602000224 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 324602000225 Bacterial Ig-like domain; Region: Big_5; pfam13205 324602000226 Citrate transporter; Region: CitMHS; pfam03600 324602000227 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 324602000228 transmembrane helices; other site 324602000229 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 324602000230 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 324602000231 active site 324602000232 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602000233 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 324602000234 Domain of unknown function (DUF309); Region: DUF309; pfam03745 324602000235 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 324602000236 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 324602000237 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602000238 Walker A motif; other site 324602000239 ATP binding site [chemical binding]; other site 324602000240 Walker B motif; other site 324602000241 arginine finger; other site 324602000242 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 324602000243 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 324602000244 Putative lysophospholipase; Region: Hydrolase_4; cl19140 324602000245 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 324602000246 Walker A/P-loop; other site 324602000247 ATP binding site [chemical binding]; other site 324602000248 ABC transporter signature motif; other site 324602000249 Walker B; other site 324602000250 D-loop; other site 324602000251 H-loop/switch region; other site 324602000252 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 324602000253 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 324602000254 protein binding surface [polypeptide binding]; other site 324602000255 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 324602000256 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 324602000257 HEAT repeats; Region: HEAT_2; pfam13646 324602000258 HEAT repeats; Region: HEAT_2; pfam13646 324602000259 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 324602000260 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 324602000261 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 324602000262 substrate binding site [chemical binding]; other site 324602000263 oxyanion hole (OAH) forming residues; other site 324602000264 trimer interface [polypeptide binding]; other site 324602000265 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 324602000266 putative active site [active] 324602000267 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 324602000268 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 324602000269 acyl-activating enzyme (AAE) consensus motif; other site 324602000270 putative AMP binding site [chemical binding]; other site 324602000271 putative active site [active] 324602000272 putative CoA binding site [chemical binding]; other site 324602000273 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 324602000274 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 324602000275 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 324602000276 trimer interface [polypeptide binding]; other site 324602000277 active site 324602000278 substrate binding site [chemical binding]; other site 324602000279 CoA binding site [chemical binding]; other site 324602000280 Transcriptional regulator [Transcription]; Region: IclR; COG1414 324602000281 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324602000282 putative DNA binding site [nucleotide binding]; other site 324602000283 putative Zn2+ binding site [ion binding]; other site 324602000284 Bacterial transcriptional regulator; Region: IclR; pfam01614 324602000285 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 324602000286 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 324602000287 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 324602000288 FeoA domain; Region: FeoA; pfam04023 324602000289 enoyl-CoA hydratase; Provisional; Region: PRK05862 324602000290 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 324602000291 substrate binding site [chemical binding]; other site 324602000292 oxyanion hole (OAH) forming residues; other site 324602000293 trimer interface [polypeptide binding]; other site 324602000294 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 324602000295 PAS domain S-box; Region: sensory_box; TIGR00229 324602000296 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602000297 putative active site [active] 324602000298 heme pocket [chemical binding]; other site 324602000299 PAS fold; Region: PAS_4; pfam08448 324602000300 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602000301 putative active site [active] 324602000302 heme pocket [chemical binding]; other site 324602000303 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602000304 dimer interface [polypeptide binding]; other site 324602000305 phosphorylation site [posttranslational modification] 324602000306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602000307 ATP binding site [chemical binding]; other site 324602000308 Mg2+ binding site [ion binding]; other site 324602000309 G-X-G motif; other site 324602000310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602000311 active site 324602000312 phosphorylation site [posttranslational modification] 324602000313 intermolecular recognition site; other site 324602000314 dimerization interface [polypeptide binding]; other site 324602000315 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 324602000316 active site 324602000317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602000318 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324602000319 putative substrate translocation pore; other site 324602000320 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602000321 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 324602000322 putative ADP-binding pocket [chemical binding]; other site 324602000323 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 324602000324 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 324602000325 Chain length determinant protein; Region: Wzz; pfam02706 324602000326 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 324602000327 AAA domain; Region: AAA_31; pfam13614 324602000328 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602000329 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602000330 active site 324602000331 phosphorylation site [posttranslational modification] 324602000332 intermolecular recognition site; other site 324602000333 dimerization interface [polypeptide binding]; other site 324602000334 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324602000335 DNA binding site [nucleotide binding] 324602000336 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324602000337 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324602000338 dimerization interface [polypeptide binding]; other site 324602000339 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602000340 dimer interface [polypeptide binding]; other site 324602000341 phosphorylation site [posttranslational modification] 324602000342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602000343 ATP binding site [chemical binding]; other site 324602000344 Mg2+ binding site [ion binding]; other site 324602000345 G-X-G motif; other site 324602000346 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 324602000347 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 324602000348 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 324602000349 rod shape-determining protein MreD; Region: MreD; cl01087 324602000350 rod shape-determining protein MreC; Provisional; Region: PRK13922 324602000351 rod shape-determining protein MreB; Provisional; Region: PRK13927 324602000352 MreB and similar proteins; Region: MreB_like; cd10225 324602000353 nucleotide binding site [chemical binding]; other site 324602000354 Mg binding site [ion binding]; other site 324602000355 putative protofilament interaction site [polypeptide binding]; other site 324602000356 RodZ interaction site [polypeptide binding]; other site 324602000357 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 324602000358 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602000359 Walker A motif; other site 324602000360 ATP binding site [chemical binding]; other site 324602000361 Walker B motif; other site 324602000362 arginine finger; other site 324602000363 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 324602000364 metal ion-dependent adhesion site (MIDAS); other site 324602000365 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 324602000366 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 324602000367 RNA binding site [nucleotide binding]; other site 324602000368 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 324602000369 RNA binding site [nucleotide binding]; other site 324602000370 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 324602000371 RNA binding site [nucleotide binding]; other site 324602000372 Ribosomal protein L34; Region: Ribosomal_L34; pfam00468 324602000373 Ribonuclease P; Region: Ribonuclease_P; pfam00825 324602000374 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 324602000375 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 324602000376 Jag N-terminus; Region: Jag_N; pfam14804 324602000377 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 324602000378 G-X-X-G motif; other site 324602000379 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 324602000380 RxxxH motif; other site 324602000381 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 324602000382 apolar tunnel; other site 324602000383 heme binding site [chemical binding]; other site 324602000384 dimerization interface [polypeptide binding]; other site 324602000385 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 324602000386 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 324602000387 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 324602000388 P loop; other site 324602000389 Nucleotide binding site [chemical binding]; other site 324602000390 DTAP/Switch II; other site 324602000391 Switch I; other site 324602000392 Bacteriochlorophyll C binding protein; Region: Bac_chlorC; pfam02043 324602000393 Protein of unknown function (DUF1032); Region: DUF1032; pfam06278 324602000394 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 324602000395 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 324602000396 P loop; other site 324602000397 Nucleotide binding site [chemical binding]; other site 324602000398 DTAP/Switch II; other site 324602000399 Switch I; other site 324602000400 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 324602000401 Putative lysophospholipase; Region: Hydrolase_4; cl19140 324602000402 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324602000403 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 324602000404 nucleophilic elbow; other site 324602000405 catalytic triad; other site 324602000406 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 324602000407 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324602000408 Putative lysophospholipase; Region: Hydrolase_4; cl19140 324602000409 Putative lysophospholipase; Region: Hydrolase_4; cl19140 324602000410 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324602000411 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 324602000412 O-methyltransferase; Region: Methyltransf_2; pfam00891 324602000413 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602000414 S-adenosylmethionine binding site [chemical binding]; other site 324602000415 Bacteriochlorophyll/chlorophyll synthetase; Region: PT_UbiA_chlorophyll; cd13958 324602000416 putative active site [active] 324602000417 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 324602000418 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 324602000419 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324602000420 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 324602000421 hydrophobic ligand binding site; other site 324602000422 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324602000423 non-specific DNA binding site [nucleotide binding]; other site 324602000424 salt bridge; other site 324602000425 sequence-specific DNA binding site [nucleotide binding]; other site 324602000426 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 324602000427 Peptidase family M23; Region: Peptidase_M23; pfam01551 324602000428 ABC-2 type transporter; Region: ABC2_membrane; cl17235 324602000429 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 324602000430 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324602000431 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 324602000432 Walker A/P-loop; other site 324602000433 ATP binding site [chemical binding]; other site 324602000434 Q-loop/lid; other site 324602000435 ABC transporter signature motif; other site 324602000436 Walker B; other site 324602000437 D-loop; other site 324602000438 H-loop/switch region; other site 324602000439 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 324602000440 hypothetical protein; Provisional; Region: PRK11770 324602000441 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 324602000442 Ribokinase-like subgroup D. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_D; cd01937 324602000443 substrate binding site [chemical binding]; other site 324602000444 ATP binding site [chemical binding]; other site 324602000445 Putative lysophospholipase; Region: Hydrolase_4; cl19140 324602000446 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324602000447 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 324602000448 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 324602000449 catalytic site [active] 324602000450 Uncharacterized conserved protein [Function unknown]; Region: COG3595 324602000451 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 324602000452 Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or...; Region: DSPc; cl00053 324602000453 LabA_like proteins; Region: LabA_like; cd06167 324602000454 putative metal binding site [ion binding]; other site 324602000455 Methyltransferase domain; Region: Methyltransf_31; pfam13847 324602000456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602000457 S-adenosylmethionine binding site [chemical binding]; other site 324602000458 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 324602000459 homooctamer interface [polypeptide binding]; other site 324602000460 active site 324602000461 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 324602000462 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 324602000463 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 324602000464 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 324602000465 putative NAD(P) binding site [chemical binding]; other site 324602000466 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 324602000467 active site 324602000468 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324602000469 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602000470 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 324602000471 DNA-binding site [nucleotide binding]; DNA binding site 324602000472 RNA-binding motif; other site 324602000473 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 324602000474 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 324602000475 PYR/PP interface [polypeptide binding]; other site 324602000476 dimer interface [polypeptide binding]; other site 324602000477 TPP binding site [chemical binding]; other site 324602000478 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 324602000479 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 324602000480 TPP-binding site [chemical binding]; other site 324602000481 dimer interface [polypeptide binding]; other site 324602000482 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 324602000483 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 324602000484 putative valine binding site [chemical binding]; other site 324602000485 dimer interface [polypeptide binding]; other site 324602000486 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 324602000487 ketol-acid reductoisomerase; Provisional; Region: PRK05479 324602000488 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 324602000489 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 324602000490 2-isopropylmalate synthase; Validated; Region: PRK00915 324602000491 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 324602000492 active site 324602000493 catalytic residues [active] 324602000494 metal binding site [ion binding]; metal-binding site 324602000495 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 324602000496 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 324602000497 Prephenate dehydratase; Region: PDT; pfam00800 324602000498 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 324602000499 putative L-Phe binding site [chemical binding]; other site 324602000500 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 324602000501 substrate binding site [chemical binding]; other site 324602000502 ligand binding site [chemical binding]; other site 324602000503 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 324602000504 substrate binding site [chemical binding]; other site 324602000505 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 324602000506 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324602000507 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 324602000508 Transglycosylase; Region: Transgly; pfam00912 324602000509 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 324602000510 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 324602000511 PASTA domain; Region: PASTA; pfam03793 324602000512 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 324602000513 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 324602000514 putative active site [active] 324602000515 putative catalytic site [active] 324602000516 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 324602000517 putative active site [active] 324602000518 putative catalytic site [active] 324602000519 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 324602000520 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 324602000521 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 324602000522 Domain of unknown function (DUF4620); Region: DUF4620; pfam15399 324602000523 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 324602000524 Uncharacterized conserved protein [Function unknown]; Region: COG3777 324602000525 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 324602000526 active site 2 [active] 324602000527 active site 1 [active] 324602000528 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 324602000529 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 324602000530 Cysteine-rich domain; Region: CCG; pfam02754 324602000531 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 324602000532 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 324602000533 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 324602000534 putative molybdopterin cofactor binding site [chemical binding]; other site 324602000535 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 324602000536 putative molybdopterin cofactor binding site; other site 324602000537 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602000538 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324602000539 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 324602000540 intracellular protease, PfpI family; Region: PfpI; TIGR01382 324602000541 proposed catalytic triad [active] 324602000542 conserved cys residue [active] 324602000543 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324602000544 metal binding site [ion binding]; metal-binding site 324602000545 active site 324602000546 I-site; other site 324602000547 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 324602000548 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 324602000549 PAS fold; Region: PAS_4; pfam08448 324602000550 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602000551 putative active site [active] 324602000552 heme pocket [chemical binding]; other site 324602000553 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 324602000554 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324602000555 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602000556 dimer interface [polypeptide binding]; other site 324602000557 phosphorylation site [posttranslational modification] 324602000558 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602000559 ATP binding site [chemical binding]; other site 324602000560 Mg2+ binding site [ion binding]; other site 324602000561 G-X-G motif; other site 324602000562 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 324602000563 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 324602000564 active site 324602000565 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324602000566 ABC-ATPase subunit interface; other site 324602000567 dimer interface [polypeptide binding]; other site 324602000568 putative PBP binding regions; other site 324602000569 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324602000570 ABC-ATPase subunit interface; other site 324602000571 dimer interface [polypeptide binding]; other site 324602000572 putative PBP binding regions; other site 324602000573 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 324602000574 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 324602000575 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 324602000576 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324602000577 intersubunit interface [polypeptide binding]; other site 324602000578 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324602000579 Coenzyme A binding pocket [chemical binding]; other site 324602000580 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 324602000581 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 324602000582 autotransporter-associated beta strand repeat; Region: autotrns_rpt; TIGR02601 324602000583 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 324602000584 Cornifin (SPRR) family; Region: Cornifin; pfam02389 324602000585 envelope glycoprotein I; Provisional; Region: PHA03292 324602000586 envelope glycoprotein I; Provisional; Region: PHA03292 324602000587 RAM signalling pathway protein; Region: SOG2; pfam10428 324602000588 envelope glycoprotein I; Provisional; Region: PHA03292 324602000589 Predicted permeases [General function prediction only]; Region: RarD; COG2962 324602000590 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 324602000591 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 324602000592 phosphate binding site [ion binding]; other site 324602000593 dimer interface [polypeptide binding]; other site 324602000594 substrate binding site [chemical binding]; other site 324602000595 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 324602000596 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 324602000597 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602000598 binding surface 324602000599 Tetratricopeptide repeat; Region: TPR_20; pfam14561 324602000600 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 324602000601 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 324602000602 TrkA-N domain; Region: TrkA_N; pfam02254 324602000603 TrkA-C domain; Region: TrkA_C; pfam02080 324602000604 Cation transport protein; Region: TrkH; cl17365 324602000605 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 324602000606 Cation transport protein; Region: TrkH; cl17365 324602000607 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 324602000608 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324602000609 FeS/SAM binding site; other site 324602000610 HemN C-terminal domain; Region: HemN_C; pfam06969 324602000611 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 324602000612 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 324602000613 FMN binding site [chemical binding]; other site 324602000614 active site 324602000615 catalytic residues [active] 324602000616 substrate binding site [chemical binding]; other site 324602000617 CSLREA domain; Region: CSLREA_Nterm; TIGR04214 324602000618 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 324602000619 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 324602000620 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 324602000621 putative acyl-acceptor binding pocket; other site 324602000622 Protein of unknown function (DUF422); Region: DUF422; cl00991 324602000623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602000624 active site 324602000625 phosphorylation site [posttranslational modification] 324602000626 intermolecular recognition site; other site 324602000627 dimerization interface [polypeptide binding]; other site 324602000628 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 324602000629 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 324602000630 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 324602000631 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 324602000632 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 324602000633 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 324602000634 oligoendopeptidase F; Region: pepF; TIGR00181 324602000635 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 324602000636 active site 324602000637 Zn binding site [ion binding]; other site 324602000638 Ion channel; Region: Ion_trans_2; pfam07885 324602000639 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 324602000640 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 324602000641 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324602000642 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324602000643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602000644 putative substrate translocation pore; other site 324602000645 Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with rhodanese-like domains found N-terminal of the metallo-beta-lactamase domain; Region: RHOD_Lact_B; cd01523 324602000646 active site residue [active] 324602000647 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 324602000648 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 324602000649 CPxP motif; other site 324602000650 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 324602000651 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 324602000652 active site residue [active] 324602000653 Putative phosphatase (DUF442); Region: DUF442; cl17385 324602000654 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 324602000655 high affinity sulphate transporter 1; Region: sulP; TIGR00815 324602000656 Sulfate transporter family; Region: Sulfate_transp; pfam00916 324602000657 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 324602000658 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 324602000659 active site residue [active] 324602000660 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 324602000661 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 324602000662 DUF35 OB-fold domain; Region: DUF35; pfam01796 324602000663 Yip1 domain; Region: Yip1; cl17815 324602000664 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 324602000665 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 324602000666 active site 324602000667 hypothetical protein; Provisional; Region: PRK04262 324602000668 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 324602000669 dimer interface [polypeptide binding]; other site 324602000670 active site 324602000671 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 324602000672 homodimer interface [polypeptide binding]; other site 324602000673 catalytic residues [active] 324602000674 NAD binding site [chemical binding]; other site 324602000675 substrate binding pocket [chemical binding]; other site 324602000676 flexible flap; other site 324602000677 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602000678 PAS fold; Region: PAS_3; pfam08447 324602000679 putative active site [active] 324602000680 heme pocket [chemical binding]; other site 324602000681 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602000682 dimer interface [polypeptide binding]; other site 324602000683 phosphorylation site [posttranslational modification] 324602000684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602000685 ATP binding site [chemical binding]; other site 324602000686 Mg2+ binding site [ion binding]; other site 324602000687 G-X-G motif; other site 324602000688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602000689 active site 324602000690 phosphorylation site [posttranslational modification] 324602000691 intermolecular recognition site; other site 324602000692 dimerization interface [polypeptide binding]; other site 324602000693 circadian clock protein KaiC; Reviewed; Region: PRK09302 324602000694 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 324602000695 Walker A motif; other site 324602000696 ATP binding site [chemical binding]; other site 324602000697 Walker B motif; other site 324602000698 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 324602000699 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 324602000700 G1 box; other site 324602000701 Walker A motif; other site 324602000702 ATP binding site [chemical binding]; other site 324602000703 GTP/Mg2+ binding site [chemical binding]; other site 324602000704 Walker B motif; other site 324602000705 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 324602000706 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 324602000707 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 324602000708 active site 324602000709 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 324602000710 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 324602000711 nucleotide binding pocket [chemical binding]; other site 324602000712 K-X-D-G motif; other site 324602000713 catalytic site [active] 324602000714 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 324602000715 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 324602000716 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 324602000717 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 324602000718 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 324602000719 Dimer interface [polypeptide binding]; other site 324602000720 BRCT sequence motif; other site 324602000721 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 324602000722 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 324602000723 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 324602000724 G1 box; other site 324602000725 putative GEF interaction site [polypeptide binding]; other site 324602000726 GTP/Mg2+ binding site [chemical binding]; other site 324602000727 Switch I region; other site 324602000728 G2 box; other site 324602000729 G3 box; other site 324602000730 Switch II region; other site 324602000731 G4 box; other site 324602000732 G5 box; other site 324602000733 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 324602000734 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 324602000735 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 324602000736 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 324602000737 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 324602000738 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 324602000739 minor groove reading motif; other site 324602000740 helix-hairpin-helix signature motif; other site 324602000741 substrate binding pocket [chemical binding]; other site 324602000742 active site 324602000743 ribonuclease PH; Reviewed; Region: rph; PRK00173 324602000744 Ribonuclease PH; Region: RNase_PH_bact; cd11362 324602000745 hexamer interface [polypeptide binding]; other site 324602000746 active site 324602000747 TPR repeat; Region: TPR_11; pfam13414 324602000748 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602000749 binding surface 324602000750 TPR motif; other site 324602000751 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602000752 binding surface 324602000753 TPR motif; other site 324602000754 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 324602000755 UV-endonuclease UvdE; Region: UvdE; cl10036 324602000756 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 324602000757 active site 324602000758 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 324602000759 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 324602000760 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 324602000761 dimer interface [polypeptide binding]; other site 324602000762 PYR/PP interface [polypeptide binding]; other site 324602000763 TPP binding site [chemical binding]; other site 324602000764 substrate binding site [chemical binding]; other site 324602000765 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778 324602000766 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 324602000767 TPP-binding site [chemical binding]; other site 324602000768 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 324602000769 MutL protein; Region: MutL; pfam13941 324602000770 Potato leaf roll virus readthrough protein; Region: PLRV_ORF5; pfam01690 324602000771 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 324602000772 Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862 324602000773 putative hydrophobic ligand binding site [chemical binding]; other site 324602000774 6-phosphofructokinase; Provisional; Region: PRK03202 324602000775 active site 324602000776 ADP/pyrophosphate binding site [chemical binding]; other site 324602000777 dimerization interface [polypeptide binding]; other site 324602000778 allosteric effector site; other site 324602000779 fructose-1,6-bisphosphate binding site; other site 324602000780 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 324602000781 EDD domain protein, DegV family; Region: DegV; TIGR00762 324602000782 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 324602000783 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 324602000784 generic binding surface II; other site 324602000785 ssDNA binding site; other site 324602000786 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324602000787 ATP binding site [chemical binding]; other site 324602000788 putative Mg++ binding site [ion binding]; other site 324602000789 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324602000790 nucleotide binding region [chemical binding]; other site 324602000791 ATP-binding site [chemical binding]; other site 324602000792 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 324602000793 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 324602000794 E3 interaction surface; other site 324602000795 lipoyl attachment site [posttranslational modification]; other site 324602000796 e3 binding domain; Region: E3_binding; pfam02817 324602000797 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 324602000798 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 324602000799 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 324602000800 Walker A/P-loop; other site 324602000801 ATP binding site [chemical binding]; other site 324602000802 Q-loop/lid; other site 324602000803 ABC transporter signature motif; other site 324602000804 Walker B; other site 324602000805 D-loop; other site 324602000806 H-loop/switch region; other site 324602000807 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 324602000808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602000809 dimer interface [polypeptide binding]; other site 324602000810 conserved gate region; other site 324602000811 putative PBP binding loops; other site 324602000812 ABC-ATPase subunit interface; other site 324602000813 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 324602000814 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602000815 dimer interface [polypeptide binding]; other site 324602000816 conserved gate region; other site 324602000817 putative PBP binding loops; other site 324602000818 ABC-ATPase subunit interface; other site 324602000819 phosphate binding protein; Region: ptsS_2; TIGR02136 324602000820 phosphate binding protein; Region: ptsS_2; TIGR02136 324602000821 adhesin; Provisional; Region: PRK09752 324602000822 Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212 324602000823 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 324602000824 amidase catalytic site [active] 324602000825 Zn binding residues [ion binding]; other site 324602000826 substrate binding site [chemical binding]; other site 324602000827 MobA/MobL family; Region: MobA_MobL; pfam03389 324602000828 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 324602000829 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 324602000830 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 324602000831 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 324602000832 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 324602000833 Histidine kinase; Region: HisKA_2; pfam07568 324602000834 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602000835 ATP binding site [chemical binding]; other site 324602000836 Mg2+ binding site [ion binding]; other site 324602000837 G-X-G motif; other site 324602000838 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 324602000839 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 324602000840 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 324602000841 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324602000842 Walker A/P-loop; other site 324602000843 ATP binding site [chemical binding]; other site 324602000844 Q-loop/lid; other site 324602000845 ABC transporter signature motif; other site 324602000846 Walker B; other site 324602000847 D-loop; other site 324602000848 H-loop/switch region; other site 324602000849 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324602000850 active site 324602000851 transcription termination factor Rho; Provisional; Region: rho; PRK09376 324602000852 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 324602000853 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 324602000854 RNA binding site [nucleotide binding]; other site 324602000855 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 324602000856 multimer interface [polypeptide binding]; other site 324602000857 Walker A motif; other site 324602000858 ATP binding site [chemical binding]; other site 324602000859 Walker B motif; other site 324602000860 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 324602000861 Double zinc ribbon; Region: DZR; pfam12773 324602000862 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 324602000863 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 324602000864 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 324602000865 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324602000866 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 324602000867 dimer interface [polypeptide binding]; other site 324602000868 active site 324602000869 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 324602000870 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 324602000871 ligand binding site [chemical binding]; other site 324602000872 NAD binding site [chemical binding]; other site 324602000873 dimerization interface [polypeptide binding]; other site 324602000874 catalytic site [active] 324602000875 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 324602000876 putative L-serine binding site [chemical binding]; other site 324602000877 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 324602000878 CHC2 zinc finger; Region: zf-CHC2; cl17510 324602000879 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 324602000880 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 324602000881 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 324602000882 valyl-tRNA synthetase-like protein; Provisional; Region: PTZ00419 324602000883 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 324602000884 Domain of unknown function DUF87; Region: DUF87; cl19135 324602000885 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602000886 Walker A motif; other site 324602000887 ATP binding site [chemical binding]; other site 324602000888 Walker B motif; other site 324602000889 arginine finger; other site 324602000890 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 324602000891 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324602000892 non-specific DNA binding site [nucleotide binding]; other site 324602000893 salt bridge; other site 324602000894 sequence-specific DNA binding site [nucleotide binding]; other site 324602000895 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 324602000896 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 324602000897 catalytic residues [active] 324602000898 catalytic nucleophile [active] 324602000899 Recombinase; Region: Recombinase; pfam07508 324602000900 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 324602000901 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 324602000902 catalytic residues [active] 324602000903 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 324602000904 substrate binding site [chemical binding]; other site 324602000905 putative active site [active] 324602000906 redox center [active] 324602000907 Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212 324602000908 CSLREA domain; Region: CSLREA_Nterm; TIGR04214 324602000909 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 324602000910 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 324602000911 CSLREA domain; Region: CSLREA_Nterm; TIGR04214 324602000912 Right handed beta helix region; Region: Beta_helix; pfam13229 324602000913 Right handed beta helix region; Region: Beta_helix; pfam13229 324602000914 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 324602000915 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 324602000916 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 324602000917 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 324602000918 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 324602000919 Thioredoxin; Region: Thioredoxin_4; pfam13462 324602000920 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 324602000921 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 324602000922 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602000923 Walker A motif; other site 324602000924 ATP binding site [chemical binding]; other site 324602000925 Walker B motif; other site 324602000926 arginine finger; other site 324602000927 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 324602000928 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 324602000929 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 324602000930 putative dimer interface [polypeptide binding]; other site 324602000931 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 324602000932 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 324602000933 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 324602000934 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 324602000935 protein binding site [polypeptide binding]; other site 324602000936 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 324602000937 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 324602000938 HSP70 interaction site [polypeptide binding]; other site 324602000939 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 324602000940 substrate binding site [polypeptide binding]; other site 324602000941 dimer interface [polypeptide binding]; other site 324602000942 Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]; Region: eRF1; COG1503 324602000943 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 324602000944 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 324602000945 Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_prohibitin; cd03401 324602000946 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 324602000947 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324602000948 putative ligand binding site [chemical binding]; other site 324602000949 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 324602000950 dimer interface [polypeptide binding]; other site 324602000951 [2Fe-2S] cluster binding site [ion binding]; other site 324602000952 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324602000953 ABC-ATPase subunit interface; other site 324602000954 dimer interface [polypeptide binding]; other site 324602000955 putative PBP binding regions; other site 324602000956 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 324602000957 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 324602000958 Walker A/P-loop; other site 324602000959 ATP binding site [chemical binding]; other site 324602000960 Q-loop/lid; other site 324602000961 ABC transporter signature motif; other site 324602000962 Walker B; other site 324602000963 D-loop; other site 324602000964 H-loop/switch region; other site 324602000965 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324602000966 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324602000967 intersubunit interface [polypeptide binding]; other site 324602000968 flavodoxin FldA; Validated; Region: PRK09267 324602000969 ApaLI-like restriction endonuclease; Region: RE_ApaLI; pfam09499 324602000970 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 324602000971 DNA methylase; Region: N6_N4_Mtase; pfam01555 324602000972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602000973 S-adenosylmethionine binding site [chemical binding]; other site 324602000974 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 324602000975 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 324602000976 Walker A/P-loop; other site 324602000977 ATP binding site [chemical binding]; other site 324602000978 Q-loop/lid; other site 324602000979 ABC transporter signature motif; other site 324602000980 Walker B; other site 324602000981 D-loop; other site 324602000982 H-loop/switch region; other site 324602000983 TOBE domain; Region: TOBE_2; pfam08402 324602000984 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 324602000985 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602000986 dimer interface [polypeptide binding]; other site 324602000987 conserved gate region; other site 324602000988 putative PBP binding loops; other site 324602000989 ABC-ATPase subunit interface; other site 324602000990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602000991 dimer interface [polypeptide binding]; other site 324602000992 conserved gate region; other site 324602000993 putative PBP binding loops; other site 324602000994 ABC-ATPase subunit interface; other site 324602000995 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 324602000996 YwiC-like protein; Region: YwiC; pfam14256 324602000997 Cupin domain; Region: Cupin_2; cl17218 324602000998 Saccharomyces cerevisiae homocitrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_HCS; cd07948 324602000999 homocitrate synthase; Region: LysS_fung_arch; TIGR02146 324602001000 active site 324602001001 catalytic residues [active] 324602001002 metal binding site [ion binding]; metal-binding site 324602001003 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 324602001004 substrate binding site [chemical binding]; other site 324602001005 ligand binding site [chemical binding]; other site 324602001006 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 324602001007 substrate binding site [chemical binding]; other site 324602001008 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 324602001009 Lysine biosynthesis protein LysW; Region: LysW; cd13946 324602001010 Zn binding site [ion binding]; other site 324602001011 ArgX binding interface [polypeptide binding]; other site 324602001012 AAA attachment site [active] 324602001013 Lysine biosynthesis protein LysW; Region: LysW; cd13946 324602001014 Zn binding site [ion binding]; other site 324602001015 ArgX binding interface [polypeptide binding]; other site 324602001016 AAA attachment site [active] 324602001017 Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144 324602001018 ATP-grasp domain; Region: ATP-grasp_4; cl17255 324602001019 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 324602001020 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 324602001021 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl19935 324602001022 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 324602001023 SPFH domain / Band 7 family; Region: Band_7; pfam01145 324602001024 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 324602001025 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 324602001026 Ligand binding site; other site 324602001027 Putative Catalytic site; other site 324602001028 DXD motif; other site 324602001029 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324602001030 Walker A/P-loop; other site 324602001031 ATP binding site [chemical binding]; other site 324602001032 Q-loop/lid; other site 324602001033 ABC transporter signature motif; other site 324602001034 Walker B; other site 324602001035 D-loop; other site 324602001036 H-loop/switch region; other site 324602001037 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324602001038 Walker A/P-loop; other site 324602001039 ATP binding site [chemical binding]; other site 324602001040 Q-loop/lid; other site 324602001041 ABC transporter signature motif; other site 324602001042 Walker B; other site 324602001043 D-loop; other site 324602001044 H-loop/switch region; other site 324602001045 DNA polymerase I; Provisional; Region: PRK05755 324602001046 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 324602001047 active site 324602001048 metal binding site 1 [ion binding]; metal-binding site 324602001049 putative 5' ssDNA interaction site; other site 324602001050 metal binding site 3; metal-binding site 324602001051 metal binding site 2 [ion binding]; metal-binding site 324602001052 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 324602001053 putative DNA binding site [nucleotide binding]; other site 324602001054 putative metal binding site [ion binding]; other site 324602001055 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 324602001056 active site 324602001057 catalytic site [active] 324602001058 substrate binding site [chemical binding]; other site 324602001059 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 324602001060 active site 324602001061 DNA binding site [nucleotide binding] 324602001062 catalytic site [active] 324602001063 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 324602001064 active site 324602001065 Zn binding site [ion binding]; other site 324602001066 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 324602001067 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 324602001068 putative active site [active] 324602001069 oxyanion strand; other site 324602001070 catalytic triad [active] 324602001071 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 324602001072 catalytic residues [active] 324602001073 Protein of unknown function (DUF2397); Region: DUF2397; cl19578 324602001074 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 324602001075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602001076 S-adenosylmethionine binding site [chemical binding]; other site 324602001077 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 324602001078 Putative lysophospholipase; Region: Hydrolase_4; cl19140 324602001079 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 324602001080 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 324602001081 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 324602001082 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 324602001083 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 324602001084 RDD family; Region: RDD; pfam06271 324602001085 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 324602001086 catalytic core [active] 324602001087 Thymidylate synthase complementing protein; Region: Thy1; cl03630 324602001088 Thymidylate synthase complementing protein; Region: Thy1; pfam02511 324602001089 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 324602001090 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 324602001091 catalytic loop [active] 324602001092 iron binding site [ion binding]; other site 324602001093 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 324602001094 putative acyl-acceptor binding pocket; other site 324602001095 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 324602001096 dimerization interface [polypeptide binding]; other site 324602001097 active site 324602001098 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 324602001099 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 324602001100 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 324602001101 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 324602001102 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324602001103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602001104 dimer interface [polypeptide binding]; other site 324602001105 conserved gate region; other site 324602001106 putative PBP binding loops; other site 324602001107 ABC-ATPase subunit interface; other site 324602001108 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 324602001109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602001110 dimer interface [polypeptide binding]; other site 324602001111 conserved gate region; other site 324602001112 putative PBP binding loops; other site 324602001113 ABC-ATPase subunit interface; other site 324602001114 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324602001115 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324602001116 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324602001117 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324602001118 DNA binding site [nucleotide binding] 324602001119 domain linker motif; other site 324602001120 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324602001121 dimerization interface [polypeptide binding]; other site 324602001122 ligand binding site [chemical binding]; other site 324602001123 LabA_like proteins; Region: LabA_like; cd06167 324602001124 putative metal binding site [ion binding]; other site 324602001125 Uncharacterized conserved protein [Function unknown]; Region: COG1432 324602001126 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 324602001127 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 324602001128 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 324602001129 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 324602001130 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 324602001131 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 324602001132 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 324602001133 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 324602001134 Domain interface; other site 324602001135 Active site tetrad [active] 324602001136 Peptide binding site; other site 324602001137 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 324602001138 protein binding site [polypeptide binding]; other site 324602001139 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324602001140 short chain dehydrogenase; Provisional; Region: PRK06181 324602001141 NAD(P) binding site [chemical binding]; other site 324602001142 active site 324602001143 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 324602001144 active site 324602001145 catalytic residues [active] 324602001146 metal binding site [ion binding]; metal-binding site 324602001147 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 324602001148 dimer interface [polypeptide binding]; other site 324602001149 substrate binding site [chemical binding]; other site 324602001150 ATP binding site [chemical binding]; other site 324602001151 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 324602001152 thiamine phosphate binding site [chemical binding]; other site 324602001153 active site 324602001154 pyrophosphate binding site [ion binding]; other site 324602001155 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 324602001156 substrate binding site [chemical binding]; other site 324602001157 multimerization interface [polypeptide binding]; other site 324602001158 ATP binding site [chemical binding]; other site 324602001159 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 324602001160 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 324602001161 short chain dehydrogenase; Provisional; Region: PRK06181 324602001162 classical (c) SDRs; Region: SDR_c; cd05233 324602001163 NAD(P) binding site [chemical binding]; other site 324602001164 active site 324602001165 Phosphotransferase enzyme family; Region: APH; pfam01636 324602001166 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 324602001167 active site 324602001168 substrate binding site [chemical binding]; other site 324602001169 ATP binding site [chemical binding]; other site 324602001170 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 324602001171 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 324602001172 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 324602001173 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 324602001174 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 324602001175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602001176 putative substrate translocation pore; other site 324602001177 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324602001178 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324602001179 DNA binding site [nucleotide binding] 324602001180 domain linker motif; other site 324602001181 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 324602001182 putative dimerization interface [polypeptide binding]; other site 324602001183 putative ligand binding site [chemical binding]; other site 324602001184 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 324602001185 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 324602001186 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 324602001187 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 324602001188 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 324602001189 23S rRNA binding site [nucleotide binding]; other site 324602001190 L21 binding site [polypeptide binding]; other site 324602001191 L13 binding site [polypeptide binding]; other site 324602001192 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 324602001193 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 324602001194 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 324602001195 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 324602001196 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 324602001197 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 324602001198 dimer interface [polypeptide binding]; other site 324602001199 motif 1; other site 324602001200 active site 324602001201 motif 2; other site 324602001202 motif 3; other site 324602001203 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 324602001204 EamA-like transporter family; Region: EamA; pfam00892 324602001205 EamA-like transporter family; Region: EamA; pfam00892 324602001206 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 324602001207 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 324602001208 Right handed beta helix region; Region: Beta_helix; pfam13229 324602001209 Right handed beta helix region; Region: Beta_helix; pfam13229 324602001210 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 324602001211 CSLREA domain; Region: CSLREA_Nterm; TIGR04214 324602001212 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 324602001213 Right handed beta helix region; Region: Beta_helix; pfam13229 324602001214 IG-like fold at C-terminal of FixG, putative oxidoreductase; Region: FixG_C; pfam11614 324602001215 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 324602001216 IG-like fold at C-terminal of FixG, putative oxidoreductase; Region: FixG_C; pfam11614 324602001217 IG-like fold at C-terminal of FixG, putative oxidoreductase; Region: FixG_C; pfam11614 324602001218 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 324602001219 trimer interface [polypeptide binding]; other site 324602001220 active site 324602001221 dimer interface [polypeptide binding]; other site 324602001222 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 324602001223 Domain of unknown function DUF59; Region: DUF59; cl00941 324602001224 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 324602001225 MPT binding site; other site 324602001226 trimer interface [polypeptide binding]; other site 324602001227 Haemolytic domain; Region: Haemolytic; pfam01809 324602001228 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 324602001229 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324602001230 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324602001231 DNA binding residues [nucleotide binding] 324602001232 MASE1; Region: MASE1; cl17823 324602001233 CHASE domain; Region: CHASE; pfam03924 324602001234 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 324602001235 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324602001236 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602001237 dimer interface [polypeptide binding]; other site 324602001238 phosphorylation site [posttranslational modification] 324602001239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602001240 ATP binding site [chemical binding]; other site 324602001241 Mg2+ binding site [ion binding]; other site 324602001242 G-X-G motif; other site 324602001243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602001244 active site 324602001245 phosphorylation site [posttranslational modification] 324602001246 intermolecular recognition site; other site 324602001247 dimerization interface [polypeptide binding]; other site 324602001248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602001249 active site 324602001250 phosphorylation site [posttranslational modification] 324602001251 intermolecular recognition site; other site 324602001252 dimerization interface [polypeptide binding]; other site 324602001253 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 324602001254 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 324602001255 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 324602001256 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 324602001257 Ligand binding site; other site 324602001258 Ligand binding site; other site 324602001259 Ligand binding site; other site 324602001260 Putative Catalytic site; other site 324602001261 DXD motif; other site 324602001262 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 324602001263 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 324602001264 Probable Catalytic site; other site 324602001265 metal-binding site 324602001266 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 324602001267 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 324602001268 NADP binding site [chemical binding]; other site 324602001269 active site 324602001270 putative substrate binding site [chemical binding]; other site 324602001271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602001272 active site 324602001273 phosphorylation site [posttranslational modification] 324602001274 intermolecular recognition site; other site 324602001275 dimerization interface [polypeptide binding]; other site 324602001276 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 324602001277 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602001278 putative active site [active] 324602001279 heme pocket [chemical binding]; other site 324602001280 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602001281 dimer interface [polypeptide binding]; other site 324602001282 phosphorylation site [posttranslational modification] 324602001283 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602001284 ATP binding site [chemical binding]; other site 324602001285 Mg2+ binding site [ion binding]; other site 324602001286 G-X-G motif; other site 324602001287 Domain of unknown function DUF11; Region: DUF11; pfam01345 324602001288 Domain of unknown function DUF11; Region: DUF11; cl17728 324602001289 Cna protein B-type domain; Region: Cna_B; pfam05738 324602001290 Cna protein B-type domain; Region: Cna_B; pfam05738 324602001291 Cna protein B-type domain; Region: Cna_B; pfam05738 324602001292 Cna protein B-type domain; Region: Cna_B; pfam05738 324602001293 Cna protein B-type domain; Region: Cna_B; pfam05738 324602001294 Cna protein B-type domain; Region: Cna_B; pfam05738 324602001295 Cna protein B-type domain; Region: Cna_B; pfam05738 324602001296 Cna protein B-type domain; Region: Cna_B; pfam05738 324602001297 Cna protein B-type domain; Region: Cna_B; pfam05738 324602001298 Cna protein B-type domain; Region: Cna_B; pfam05738 324602001299 Cna protein B-type domain; Region: Cna_B; pfam05738 324602001300 Cna protein B-type domain; Region: Cna_B; pfam05738 324602001301 Cna protein B-type domain; Region: Cna_B; pfam05738 324602001302 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 324602001303 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 324602001304 Cna protein B-type domain; Region: Cna_B; pfam05738 324602001305 Cna protein B-type domain; Region: Cna_B; pfam05738 324602001306 Cna protein B-type domain; Region: Cna_B; pfam05738 324602001307 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 324602001308 Cna protein B-type domain; Region: Cna_B; pfam05738 324602001309 Cna protein B-type domain; Region: Cna_B; pfam05738 324602001310 Cna protein B-type domain; Region: Cna_B; pfam05738 324602001311 Cna protein B-type domain; Region: Cna_B; pfam05738 324602001312 PUCC protein; Region: PUCC; pfam03209 324602001313 folate/biopterin transporter; Region: fbt; TIGR00788 324602001314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602001315 putative substrate translocation pore; other site 324602001316 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 324602001317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602001318 S-adenosylmethionine binding site [chemical binding]; other site 324602001319 2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284 324602001320 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202 324602001321 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 324602001322 putative NAD(P) binding site [chemical binding]; other site 324602001323 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 324602001324 chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016 324602001325 Cell division protein FtsQ; Region: FtsQ; pfam03799 324602001326 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 324602001327 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 324602001328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602001329 Walker A motif; other site 324602001330 ATP binding site [chemical binding]; other site 324602001331 Walker B motif; other site 324602001332 arginine finger; other site 324602001333 magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031 324602001334 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602001335 ATP binding site [chemical binding]; other site 324602001336 Walker B motif; other site 324602001337 arginine finger; other site 324602001338 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 324602001339 metal ion-dependent adhesion site (MIDAS); other site 324602001340 recombination factor protein RarA; Reviewed; Region: PRK13342 324602001341 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602001342 Walker A motif; other site 324602001343 ATP binding site [chemical binding]; other site 324602001344 Walker B motif; other site 324602001345 arginine finger; other site 324602001346 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 324602001347 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 324602001348 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 324602001349 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 324602001350 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 324602001351 Walker A/P-loop; other site 324602001352 ATP binding site [chemical binding]; other site 324602001353 Q-loop/lid; other site 324602001354 ABC transporter signature motif; other site 324602001355 Walker B; other site 324602001356 D-loop; other site 324602001357 H-loop/switch region; other site 324602001358 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 324602001359 NMT1/THI5 like; Region: NMT1; pfam09084 324602001360 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 324602001361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602001362 dimer interface [polypeptide binding]; other site 324602001363 conserved gate region; other site 324602001364 putative PBP binding loops; other site 324602001365 ABC-ATPase subunit interface; other site 324602001366 Domain of unknown function DUF77; Region: DUF77; pfam01910 324602001367 Methyltransferase domain; Region: Methyltransf_31; pfam13847 324602001368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602001369 S-adenosylmethionine binding site [chemical binding]; other site 324602001370 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 324602001371 Membrane protein of unknown function; Region: DUF360; pfam04020 324602001372 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 324602001373 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 324602001374 active site 324602001375 catalytic site [active] 324602001376 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 324602001377 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324602001378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602001379 homodimer interface [polypeptide binding]; other site 324602001380 catalytic residue [active] 324602001381 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 324602001382 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 324602001383 HAS barrel domain; Region: HAS-barrel; pfam09378 324602001384 NurA domain; Region: NurA; pfam09376 324602001385 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 324602001386 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 324602001387 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 324602001388 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 324602001389 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 324602001390 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 324602001391 HflX GTPase family; Region: HflX; cd01878 324602001392 G1 box; other site 324602001393 GTP/Mg2+ binding site [chemical binding]; other site 324602001394 Switch I region; other site 324602001395 G2 box; other site 324602001396 G3 box; other site 324602001397 Switch II region; other site 324602001398 G4 box; other site 324602001399 G5 box; other site 324602001400 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 324602001401 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 324602001402 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 324602001403 Small T antigen; Reviewed; Region: PHA03102 324602001404 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324602001405 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 324602001406 seryl-tRNA synthetase; Provisional; Region: PRK05431 324602001407 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 324602001408 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 324602001409 dimer interface [polypeptide binding]; other site 324602001410 active site 324602001411 motif 1; other site 324602001412 motif 2; other site 324602001413 motif 3; other site 324602001414 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 324602001415 putative active site [active] 324602001416 nucleotide binding site [chemical binding]; other site 324602001417 nudix motif; other site 324602001418 putative metal binding site [ion binding]; other site 324602001419 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 324602001420 nudix motif; other site 324602001421 DNA repair protein RadA; Provisional; Region: PRK11823 324602001422 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 324602001423 Walker A motif/ATP binding site; other site 324602001424 ATP binding site [chemical binding]; other site 324602001425 Walker B motif; other site 324602001426 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 324602001427 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 324602001428 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 324602001429 putative active site [active] 324602001430 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 324602001431 putative active site [active] 324602001432 dimerization interface [polypeptide binding]; other site 324602001433 putative tRNAtyr binding site [nucleotide binding]; other site 324602001434 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 324602001435 MgtC family; Region: MgtC; pfam02308 324602001436 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 324602001437 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 324602001438 oligomer interface [polypeptide binding]; other site 324602001439 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 324602001440 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 324602001441 oligomer interface [polypeptide binding]; other site 324602001442 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 324602001443 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 324602001444 oligomer interface [polypeptide binding]; other site 324602001445 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 324602001446 dinuclear metal binding motif [ion binding]; other site 324602001447 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324602001448 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602001449 ATP binding site [chemical binding]; other site 324602001450 Mg2+ binding site [ion binding]; other site 324602001451 G-X-G motif; other site 324602001452 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 324602001453 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 324602001454 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 324602001455 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 324602001456 PAS domain; Region: PAS; smart00091 324602001457 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602001458 dimer interface [polypeptide binding]; other site 324602001459 phosphorylation site [posttranslational modification] 324602001460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602001461 ATP binding site [chemical binding]; other site 324602001462 Mg2+ binding site [ion binding]; other site 324602001463 G-X-G motif; other site 324602001464 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 324602001465 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 324602001466 catalytic triad [active] 324602001467 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 324602001468 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 324602001469 catalytic triad [active] 324602001470 glutamate racemase; Provisional; Region: PRK00865 324602001471 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 324602001472 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 324602001473 VanW like protein; Region: VanW; pfam04294 324602001474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602001475 ATP binding site [chemical binding]; other site 324602001476 Mg2+ binding site [ion binding]; other site 324602001477 G-X-G motif; other site 324602001478 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602001479 active site 324602001480 phosphorylation site [posttranslational modification] 324602001481 intermolecular recognition site; other site 324602001482 dimerization interface [polypeptide binding]; other site 324602001483 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 324602001484 GAF domain; Region: GAF_3; pfam13492 324602001485 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602001486 PAS domain; Region: PAS_9; pfam13426 324602001487 putative active site [active] 324602001488 heme pocket [chemical binding]; other site 324602001489 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602001490 dimer interface [polypeptide binding]; other site 324602001491 phosphorylation site [posttranslational modification] 324602001492 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 324602001493 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 324602001494 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 324602001495 glutaminase active site [active] 324602001496 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 324602001497 dimer interface [polypeptide binding]; other site 324602001498 active site 324602001499 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 324602001500 dimer interface [polypeptide binding]; other site 324602001501 active site 324602001502 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 324602001503 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 324602001504 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 324602001505 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 324602001506 P loop; other site 324602001507 Nucleotide binding site [chemical binding]; other site 324602001508 DTAP/Switch II; other site 324602001509 Switch I; other site 324602001510 Zinc ribbon domain; Region: Zn-ribbon_8; pfam09723 324602001511 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 324602001512 putative carbohydrate kinase; Provisional; Region: PRK10565 324602001513 Uncharacterized conserved protein [Function unknown]; Region: COG0062 324602001514 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 324602001515 putative substrate binding site [chemical binding]; other site 324602001516 putative ATP binding site [chemical binding]; other site 324602001517 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 324602001518 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 324602001519 LexA repressor; Validated; Region: PRK00215 324602001520 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 324602001521 Catalytic site [active] 324602001522 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 324602001523 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 324602001524 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 324602001525 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 324602001526 Walker A/P-loop; other site 324602001527 ATP binding site [chemical binding]; other site 324602001528 Q-loop/lid; other site 324602001529 ABC transporter signature motif; other site 324602001530 Walker B; other site 324602001531 D-loop; other site 324602001532 H-loop/switch region; other site 324602001533 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 324602001534 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 324602001535 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 324602001536 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 324602001537 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 324602001538 Transcriptional regulator [Transcription]; Region: LytR; COG1316 324602001539 integral membrane protein MviN; Region: mviN; TIGR01695 324602001540 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 324602001541 Inosine-uridine nucleoside N-ribohydrolase [Nucleotide transport and metabolism]; Region: URH1; COG1957 324602001542 active site 324602001543 RNase_H superfamily; Region: RNase_H_2; pfam13482 324602001544 active site 324602001545 substrate binding site [chemical binding]; other site 324602001546 catalytic site [active] 324602001547 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 324602001548 Catalytic domain of Protein Kinases; Region: PKc; cd00180 324602001549 active site 324602001550 ATP binding site [chemical binding]; other site 324602001551 substrate binding site [chemical binding]; other site 324602001552 activation loop (A-loop); other site 324602001553 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 324602001554 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 324602001555 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324602001556 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 324602001557 Walker A/P-loop; other site 324602001558 ATP binding site [chemical binding]; other site 324602001559 Q-loop/lid; other site 324602001560 ABC transporter signature motif; other site 324602001561 Walker B; other site 324602001562 D-loop; other site 324602001563 H-loop/switch region; other site 324602001564 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 324602001565 homodimer interface [polypeptide binding]; other site 324602001566 substrate-cofactor binding pocket; other site 324602001567 catalytic residue [active] 324602001568 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 324602001569 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 324602001570 active site 324602001571 dimerization interface [polypeptide binding]; other site 324602001572 peptide chain release factor 1; Validated; Region: prfA; PRK00591 324602001573 This domain is found in peptide chain release factors; Region: PCRF; smart00937 324602001574 RF-1 domain; Region: RF-1; pfam00472 324602001575 Ribosomal protein S21; Region: Ribosomal_S21; pfam01165 324602001576 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 324602001577 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 324602001578 active site 324602001579 catalytic site [active] 324602001580 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324602001581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602001582 dimer interface [polypeptide binding]; other site 324602001583 conserved gate region; other site 324602001584 putative PBP binding loops; other site 324602001585 ABC-ATPase subunit interface; other site 324602001586 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324602001587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602001588 dimer interface [polypeptide binding]; other site 324602001589 conserved gate region; other site 324602001590 putative PBP binding loops; other site 324602001591 ABC-ATPase subunit interface; other site 324602001592 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 324602001593 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 324602001594 Transcriptional regulators [Transcription]; Region: MarR; COG1846 324602001595 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324602001596 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 324602001597 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 324602001598 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 324602001599 Transcriptional regulator [Transcription]; Region: LytR; COG1316 324602001600 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 324602001601 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 324602001602 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 324602001603 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 324602001604 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 324602001605 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 324602001606 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 324602001607 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 324602001608 adenosine deaminase; Provisional; Region: PRK09358 324602001609 active site 324602001610 UbiA family of prenyltransferases (PTases), Unknown subgroup; Region: PT_UbiA_2; cd13963 324602001611 putative active site [active] 324602001612 AAK_FomA-like: This CD includes a fosfomycin biosynthetic gene product, FomA, and similar proteins found in a wide range of organisms. Together, the fomA and fomB genes in the fosfomycin biosynthetic gene cluster of Streptomyces wedmorensis confer...; Region: AAK_FomA-like; cd04241 324602001613 putative nucleotide binding site [chemical binding]; other site 324602001614 putative substrate binding site [chemical binding]; other site 324602001615 Integral membrane protein DUF95; Region: DUF95; pfam01944 324602001616 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 324602001617 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 324602001618 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 324602001619 Type II secretion system (T2SS), protein F; Region: T2SF; cl19503 324602001620 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 324602001621 ATP binding site [chemical binding]; other site 324602001622 Walker A motif; other site 324602001623 hexamer interface [polypeptide binding]; other site 324602001624 Walker B motif; other site 324602001625 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 324602001626 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 324602001627 Putative lysophospholipase; Region: Hydrolase_4; cl19140 324602001628 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 324602001629 ligand binding site [chemical binding]; other site 324602001630 active site 324602001631 trehalose synthase; Region: treS_nterm; TIGR02456 324602001632 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 324602001633 Ca binding site [ion binding]; other site 324602001634 active site 324602001635 catalytic site [active] 324602001636 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 324602001637 Actin-Fragmin Kinase (AFK); catalytic domain. The AFK catalytic domain is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, aminoglycoside...; Region: AFK; cl07713 324602001638 ATP binding site [chemical binding]; other site 324602001639 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 324602001640 recombination protein RecR; Reviewed; Region: recR; PRK00076 324602001641 RecR protein; Region: RecR; pfam02132 324602001642 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 324602001643 putative active site [active] 324602001644 putative metal-binding site [ion binding]; other site 324602001645 tetramer interface [polypeptide binding]; other site 324602001646 hypothetical protein; Provisional; Region: PRK14627 324602001647 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 324602001648 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602001649 Walker A motif; other site 324602001650 ATP binding site [chemical binding]; other site 324602001651 Walker B motif; other site 324602001652 arginine finger; other site 324602001653 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 324602001654 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 324602001655 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 324602001656 VPS10 domain; Region: VPS10; smart00602 324602001657 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324602001658 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602001659 dimer interface [polypeptide binding]; other site 324602001660 phosphorylation site [posttranslational modification] 324602001661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602001662 ATP binding site [chemical binding]; other site 324602001663 Mg2+ binding site [ion binding]; other site 324602001664 G-X-G motif; other site 324602001665 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324602001666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602001667 active site 324602001668 phosphorylation site [posttranslational modification] 324602001669 intermolecular recognition site; other site 324602001670 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078 324602001671 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602001672 active site 324602001673 phosphorylation site [posttranslational modification] 324602001674 intermolecular recognition site; other site 324602001675 dimerization interface [polypeptide binding]; other site 324602001676 PAS domain; Region: PAS_9; pfam13426 324602001677 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602001678 putative active site [active] 324602001679 heme pocket [chemical binding]; other site 324602001680 GAF domain; Region: GAF_3; pfam13492 324602001681 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 324602001682 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324602001683 Zn2+ binding site [ion binding]; other site 324602001684 Mg2+ binding site [ion binding]; other site 324602001685 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 324602001686 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 324602001687 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324602001688 nucleotide binding region [chemical binding]; other site 324602001689 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 324602001690 SEC-C motif; Region: SEC-C; pfam02810 324602001691 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 324602001692 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 324602001693 Walker A/P-loop; other site 324602001694 ATP binding site [chemical binding]; other site 324602001695 Q-loop/lid; other site 324602001696 ABC transporter signature motif; other site 324602001697 Walker B; other site 324602001698 D-loop; other site 324602001699 H-loop/switch region; other site 324602001700 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 324602001701 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 324602001702 TM-ABC transporter signature motif; other site 324602001703 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 324602001704 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 324602001705 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 324602001706 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 324602001707 hypothetical protein; Provisional; Region: PRK07233 324602001708 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 324602001709 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 324602001710 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 324602001711 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 324602001712 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324602001713 putative Zn2+ binding site [ion binding]; other site 324602001714 putative DNA binding site [nucleotide binding]; other site 324602001715 Glycoside hydrolase families 71, 99, and related domains; Region: GH99_GH71_like; cl01529 324602001716 putative catalytic site [active] 324602001717 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 324602001718 Na binding site [ion binding]; other site 324602001719 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 324602001720 Right handed beta helix region; Region: Beta_helix; pfam13229 324602001721 Deoxyhypusine synthase; Region: DS; cl00826 324602001722 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 324602001723 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 324602001724 ligand binding site [chemical binding]; other site 324602001725 flexible hinge region; other site 324602001726 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 324602001727 putative switch regulator; other site 324602001728 non-specific DNA interactions [nucleotide binding]; other site 324602001729 DNA binding site [nucleotide binding] 324602001730 sequence specific DNA binding site [nucleotide binding]; other site 324602001731 putative cAMP binding site [chemical binding]; other site 324602001732 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 324602001733 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 324602001734 Protein of unknown function (DUF3179); Region: DUF3179; pfam11376 324602001735 potassium/proton antiporter; Reviewed; Region: PRK05326 324602001736 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 324602001737 TrkA-C domain; Region: TrkA_C; pfam02080 324602001738 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 324602001739 PhoU domain; Region: PhoU; pfam01895 324602001740 PhoU domain; Region: PhoU; pfam01895 324602001741 Staphylococcal nuclease homologue; Region: SNase; cl00140 324602001742 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 324602001743 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 324602001744 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 324602001745 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 324602001746 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 324602001747 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 324602001748 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 324602001749 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl19001 324602001750 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437 324602001751 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438 324602001752 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09684 324602001753 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647 324602001754 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 324602001755 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 324602001756 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 324602001757 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 324602001758 Cu(I) binding site [ion binding]; other site 324602001759 Protein of unknown function (DUF461); Region: DUF461; pfam04314 324602001760 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 324602001761 Uncharacterized conserved protein [Function unknown]; Region: COG3375 324602001762 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324602001763 Coenzyme A binding pocket [chemical binding]; other site 324602001764 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 324602001765 CPxP motif; other site 324602001766 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 324602001767 Tryptophanase [Amino acid transport and metabolism]; Region: TnaA; COG3033 324602001768 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 324602001769 substrate binding site [chemical binding]; other site 324602001770 tetramer interface [polypeptide binding]; other site 324602001771 catalytic residue [active] 324602001772 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 324602001773 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 324602001774 nucleotide binding site [chemical binding]; other site 324602001775 diaminopimelate decarboxylase; Region: lysA; TIGR01048 324602001776 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 324602001777 active site 324602001778 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 324602001779 substrate binding site [chemical binding]; other site 324602001780 catalytic residues [active] 324602001781 dimer interface [polypeptide binding]; other site 324602001782 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 324602001783 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 324602001784 metal-binding site [ion binding] 324602001785 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 324602001786 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 324602001787 metal-binding site [ion binding] 324602001788 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 324602001789 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324602001790 motif II; other site 324602001791 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 324602001792 metal-binding site [ion binding] 324602001793 Thermus thermophilus CsoR, a Cu(I)-sensing transcriptional regulator, and related domains; this domain family was previously known as part of DUF156; Region: TthCsoR-like_DUF156; cd10151 324602001794 putative homodimer interface [polypeptide binding]; other site 324602001795 putative homotetramer interface [polypeptide binding]; other site 324602001796 allosteric switch controlling residues; other site 324602001797 putative metal binding site [ion binding]; other site 324602001798 putative homodimer-homodimer interface [polypeptide binding]; other site 324602001799 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 324602001800 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324602001801 Walker A/P-loop; other site 324602001802 ATP binding site [chemical binding]; other site 324602001803 Q-loop/lid; other site 324602001804 ABC transporter signature motif; other site 324602001805 Walker B; other site 324602001806 D-loop; other site 324602001807 H-loop/switch region; other site 324602001808 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 324602001809 NAD(P) binding site [chemical binding]; other site 324602001810 catalytic residues [active] 324602001811 CHAT domain; Region: CHAT; pfam12770 324602001812 AAA ATPase domain; Region: AAA_16; pfam13191 324602001813 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 324602001814 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 324602001815 catalytic residues [active] 324602001816 YtkA-like; Region: YtkA; pfam13115 324602001817 Protein of unknown function (DUF507); Region: DUF507; cl01112 324602001818 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 324602001819 intersubunit interface [polypeptide binding]; other site 324602001820 active site 324602001821 Zn2+ binding site [ion binding]; other site 324602001822 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951 324602001823 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324602001824 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 324602001825 NAD(P) binding site [chemical binding]; other site 324602001826 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602001827 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 324602001828 DNA binding site [nucleotide binding] 324602001829 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602001830 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 324602001831 DNA binding site [nucleotide binding] 324602001832 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 324602001833 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 324602001834 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 324602001835 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 324602001836 active site residue [active] 324602001837 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324602001838 sequence-specific DNA binding site [nucleotide binding]; other site 324602001839 salt bridge; other site 324602001840 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 324602001841 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324602001842 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 324602001843 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 324602001844 TrkA-C domain; Region: TrkA_C; pfam02080 324602001845 TrkA-C domain; Region: TrkA_C; pfam02080 324602001846 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 324602001847 EamA-like transporter family; Region: EamA; cl17759 324602001848 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 324602001849 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 324602001850 Walker A/P-loop; other site 324602001851 ATP binding site [chemical binding]; other site 324602001852 Q-loop/lid; other site 324602001853 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 324602001854 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 324602001855 ABC transporter signature motif; other site 324602001856 Walker B; other site 324602001857 D-loop; other site 324602001858 H-loop/switch region; other site 324602001859 O-antigen ligase like membrane protein; Region: O-antigen_lig; cl04850 324602001860 O-antigen ligase like membrane protein; Region: O-antigen_lig; cl04850 324602001861 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602001862 TPR motif; other site 324602001863 binding surface 324602001864 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 324602001865 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 324602001866 Mg++ binding site [ion binding]; other site 324602001867 putative catalytic motif [active] 324602001868 substrate binding site [chemical binding]; other site 324602001869 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 324602001870 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 324602001871 acyl-activating enzyme (AAE) consensus motif; other site 324602001872 AMP binding site [chemical binding]; other site 324602001873 active site 324602001874 CoA binding site [chemical binding]; other site 324602001875 enoyl-CoA hydratase; Provisional; Region: PRK07658 324602001876 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 324602001877 substrate binding site [chemical binding]; other site 324602001878 oxyanion hole (OAH) forming residues; other site 324602001879 trimer interface [polypeptide binding]; other site 324602001880 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 324602001881 NAD(P) binding site [chemical binding]; other site 324602001882 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 324602001883 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 324602001884 active site 324602001885 substrate binding site [chemical binding]; other site 324602001886 ATP binding site [chemical binding]; other site 324602001887 Bacterial SH3 domain; Region: SH3_3; pfam08239 324602001888 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 324602001889 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 324602001890 active site 324602001891 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 324602001892 diphosphomevalonate decarboxylase; Region: PLN02407 324602001893 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 324602001894 Transposase IS200 like; Region: Y1_Tnp; cl00848 324602001895 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 324602001896 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 324602001897 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 324602001898 MOFRL family; Region: MOFRL; pfam05161 324602001899 GTP-binding protein YchF; Reviewed; Region: PRK09601 324602001900 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 324602001901 G1 box; other site 324602001902 GTP/Mg2+ binding site [chemical binding]; other site 324602001903 G2 box; other site 324602001904 Switch I region; other site 324602001905 G3 box; other site 324602001906 Switch II region; other site 324602001907 G4 box; other site 324602001908 G5 box; other site 324602001909 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 324602001910 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 324602001911 heme-binding residues [chemical binding]; other site 324602001912 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 324602001913 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 324602001914 molybdopterin cofactor binding site; other site 324602001915 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 324602001916 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 324602001917 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 324602001918 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 324602001919 Polysulphide reductase, NrfD; Region: NrfD; cl19193 324602001920 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 324602001921 Cytochrome c; Region: Cytochrom_C; pfam00034 324602001922 GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441 324602001923 GIY-YIG motif/motif A; other site 324602001924 putative active site [active] 324602001925 putative metal binding site [ion binding]; other site 324602001926 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 324602001927 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 324602001928 ATP-grasp domain; Region: ATP-grasp_4; cl17255 324602001929 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 324602001930 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 324602001931 active site 324602001932 substrate binding site [chemical binding]; other site 324602001933 cosubstrate binding site; other site 324602001934 catalytic site [active] 324602001935 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 324602001936 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 324602001937 active site 324602001938 ATP binding site [chemical binding]; other site 324602001939 Integral membrane undecaprenol kinase and similar enzymes; Region: UDPK_IM_like; cd14265 324602001940 trimer interface [polypeptide binding]; other site 324602001941 putative active site [active] 324602001942 Zn binding site [ion binding]; other site 324602001943 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 324602001944 catalytic core [active] 324602001945 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 324602001946 Imelysin; Region: Peptidase_M75; pfam09375 324602001947 Iron permease FTR1 family; Region: FTR1; cl00475 324602001948 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 324602001949 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 324602001950 putative FMN binding site [chemical binding]; other site 324602001951 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 324602001952 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 324602001953 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 324602001954 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602001955 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 324602001956 Methyltransferase domain; Region: Methyltransf_31; pfam13847 324602001957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602001958 S-adenosylmethionine binding site [chemical binding]; other site 324602001959 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 324602001960 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324602001961 FeS/SAM binding site; other site 324602001962 HemN C-terminal domain; Region: HemN_C; pfam06969 324602001963 protoporphyrinogen oxidase; Region: PLN02576 324602001964 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 324602001965 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 324602001966 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 324602001967 NHL repeat; Region: NHL; pfam01436 324602001968 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 324602001969 NHL repeat; Region: NHL; pfam01436 324602001970 Clostripain family; Region: Peptidase_C11; pfam03415 324602001971 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 324602001972 putative active site [active] 324602001973 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 324602001974 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 324602001975 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; cl08459 324602001976 Kelch motif; Region: Kelch_5; pfam13854 324602001977 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 324602001978 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 324602001979 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 324602001980 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 324602001981 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 324602001982 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 324602001983 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 324602001984 Subtilase family; Region: Peptidase_S8; pfam00082 324602001985 active site 324602001986 catalytic triad [active] 324602001987 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324602001988 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 324602001989 Peptidase family M23; Region: Peptidase_M23; pfam01551 324602001990 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; cl08459 324602001991 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324602001992 Interdomain contacts; other site 324602001993 Cytokine receptor motif; other site 324602001994 Clostripain family; Region: Peptidase_C11; pfam03415 324602001995 monogalactosyldiacylglycerol synthase; Region: PLN02605 324602001996 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 324602001997 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl19139 324602001998 monogalactosyldiacylglycerol synthase; Region: PLN02605 324602001999 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 324602002000 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324602002001 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 324602002002 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 324602002003 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 324602002004 Histidine kinase; Region: HisKA_3; pfam07730 324602002005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602002006 ATP binding site [chemical binding]; other site 324602002007 Mg2+ binding site [ion binding]; other site 324602002008 G-X-G motif; other site 324602002009 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 324602002010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602002011 DNA methylase; Region: N6_N4_Mtase; pfam01555 324602002012 Uncharacterized protein conserved in archaea (DUF2115); Region: DUF2115; cl01681 324602002013 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324602002014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602002015 active site 324602002016 phosphorylation site [posttranslational modification] 324602002017 intermolecular recognition site; other site 324602002018 dimerization interface [polypeptide binding]; other site 324602002019 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324602002020 DNA binding residues [nucleotide binding] 324602002021 dimerization interface [polypeptide binding]; other site 324602002022 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 324602002023 Histidine kinase; Region: HisKA_3; pfam07730 324602002024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602002025 ATP binding site [chemical binding]; other site 324602002026 Mg2+ binding site [ion binding]; other site 324602002027 G-X-G motif; other site 324602002028 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 324602002029 Zn binding site [ion binding]; other site 324602002030 histone-like DNA-binding protein HU; Region: HU; cd13831 324602002031 dimer interface [polypeptide binding]; other site 324602002032 DNA binding site [nucleotide binding] 324602002033 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 324602002034 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 324602002035 G1 box; other site 324602002036 GTP/Mg2+ binding site [chemical binding]; other site 324602002037 G2 box; other site 324602002038 Switch I region; other site 324602002039 G3 box; other site 324602002040 Switch II region; other site 324602002041 G4 box; other site 324602002042 G5 box; other site 324602002043 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 324602002044 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 324602002045 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 324602002046 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 324602002047 Ligand Binding Site [chemical binding]; other site 324602002048 Putative lysophospholipase; Region: Hydrolase_4; cl19140 324602002049 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324602002050 Putative lysophospholipase; Region: Hydrolase_4; cl19140 324602002051 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324602002052 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 324602002053 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 324602002054 acyl-activating enzyme (AAE) consensus motif; other site 324602002055 putative AMP binding site [chemical binding]; other site 324602002056 putative active site [active] 324602002057 putative CoA binding site [chemical binding]; other site 324602002058 SPFH domain / Band 7 family; Region: Band_7; pfam01145 324602002059 prohibitin homologues; Region: PHB; smart00244 324602002060 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 324602002061 SPFH domain / Band 7 family; Region: Band_7; pfam01145 324602002062 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 324602002063 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324602002064 non-specific DNA binding site [nucleotide binding]; other site 324602002065 salt bridge; other site 324602002066 sequence-specific DNA binding site [nucleotide binding]; other site 324602002067 Domain of unknown function (DUF955); Region: DUF955; cl01076 324602002068 PemK-like protein; Region: PemK; pfam02452 324602002069 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 324602002070 FAD binding domain; Region: FAD_binding_4; pfam01565 324602002071 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 324602002072 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 324602002073 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 324602002074 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 324602002075 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 324602002076 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 324602002077 PUCC protein; Region: PUCC; pfam03209 324602002078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602002079 putative substrate translocation pore; other site 324602002080 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 324602002081 substrate binding site [chemical binding]; other site 324602002082 active site 324602002083 catalytic residues [active] 324602002084 heterodimer interface [polypeptide binding]; other site 324602002085 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 324602002086 AsnC family; Region: AsnC_trans_reg; pfam01037 324602002087 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 324602002088 sulfite reductase subunit beta; Provisional; Region: PRK13504 324602002089 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 324602002090 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 324602002091 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 324602002092 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 324602002093 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 324602002094 active site 324602002095 SAM binding site [chemical binding]; other site 324602002096 homodimer interface [polypeptide binding]; other site 324602002097 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 324602002098 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 324602002099 Sirohaem synthase dimerization region; Region: CysG_dimeriser; pfam10414 324602002100 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 324602002101 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 324602002102 ATP-sulfurylase; Region: ATPS; cd00517 324602002103 active site 324602002104 HXXH motif; other site 324602002105 flexible loop; other site 324602002106 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 324602002107 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 324602002108 Active Sites [active] 324602002109 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 324602002110 ligand-binding site [chemical binding]; other site 324602002111 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602002112 binding surface 324602002113 TPR motif; other site 324602002114 TPR repeat; Region: TPR_11; pfam13414 324602002115 TPR repeat; Region: TPR_11; pfam13414 324602002116 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602002117 binding surface 324602002118 TPR motif; other site 324602002119 Tetratricopeptide repeat; Region: TPR_16; pfam13432 324602002120 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 324602002121 Nucleoside diphosphate kinase; Region: NDK; pfam00334 324602002122 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 324602002123 active site 324602002124 multimer interface [polypeptide binding]; other site 324602002125 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 324602002126 DAHP synthetase I family; Region: DAHP_synth_1; cl17225 324602002127 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 324602002128 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 324602002129 substrate binding site [chemical binding]; other site 324602002130 ATP binding site [chemical binding]; other site 324602002131 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 324602002132 intersubunit interface [polypeptide binding]; other site 324602002133 active site 324602002134 catalytic residue [active] 324602002135 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 324602002136 CoA binding domain; Region: CoA_binding; smart00881 324602002137 CoA-ligase; Region: Ligase_CoA; pfam00549 324602002138 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 324602002139 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 324602002140 Histidine kinase; Region: HisKA_3; pfam07730 324602002141 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602002142 ATP binding site [chemical binding]; other site 324602002143 Mg2+ binding site [ion binding]; other site 324602002144 G-X-G motif; other site 324602002145 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 324602002146 [2Fe-2S] cluster binding site [ion binding]; other site 324602002147 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 324602002148 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 324602002149 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 324602002150 homodimer interface [polypeptide binding]; other site 324602002151 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 324602002152 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 324602002153 active site 324602002154 homodimer interface [polypeptide binding]; other site 324602002155 catalytic site [active] 324602002156 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324602002157 Interdomain contacts; other site 324602002158 Cytokine receptor motif; other site 324602002159 Starch binding domain; Region: CBM_2; smart01065 324602002160 starch-binding site 2 [chemical binding]; other site 324602002161 starch-binding site 1 [chemical binding]; other site 324602002162 PspC domain; Region: PspC; pfam04024 324602002163 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 324602002164 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 324602002165 active site 324602002166 metal binding site [ion binding]; metal-binding site 324602002167 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 324602002168 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 324602002169 putative glycosyl transferase; Provisional; Region: PRK10307 324602002170 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 324602002171 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 324602002172 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 324602002173 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 324602002174 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 324602002175 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602002176 TPR motif; other site 324602002177 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 324602002178 DNA photolyase; Region: DNA_photolyase; pfam00875 324602002179 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 324602002180 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 324602002181 Subtilase family; Region: Peptidase_S8; pfam00082 324602002182 active site 324602002183 catalytic triad [active] 324602002184 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 324602002185 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324602002186 non-specific DNA binding site [nucleotide binding]; other site 324602002187 salt bridge; other site 324602002188 sequence-specific DNA binding site [nucleotide binding]; other site 324602002189 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 324602002190 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 324602002191 DNA topoisomerase III; Provisional; Region: PRK14724 324602002192 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 324602002193 active site 324602002194 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 324602002195 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 324602002196 Domain of unknown function DUF87; Region: DUF87; cl19135 324602002197 HerA helicase [Replication, recombination, and repair]; Region: COG0433 324602002198 NurA domain; Region: NurA; pfam09376 324602002199 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 324602002200 Part of AAA domain; Region: AAA_19; pfam13245 324602002201 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 324602002202 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 324602002203 active site 324602002204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602002205 active site 324602002206 phosphorylation site [posttranslational modification] 324602002207 intermolecular recognition site; other site 324602002208 dimerization interface [polypeptide binding]; other site 324602002209 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 324602002210 nucleotide binding site/active site [active] 324602002211 HIT family signature motif; other site 324602002212 catalytic residue [active] 324602002213 peptide chain release factor 2; Provisional; Region: PRK05589 324602002214 This domain is found in peptide chain release factors; Region: PCRF; smart00937 324602002215 RF-1 domain; Region: RF-1; pfam00472 324602002216 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 324602002217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 324602002218 Peptidase family M23; Region: Peptidase_M23; pfam01551 324602002219 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324602002220 Interdomain contacts; other site 324602002221 Cytokine receptor motif; other site 324602002222 Low molecular weight phosphatase family; Region: LMWPc; cl00105 324602002223 active site 324602002224 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 324602002225 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 324602002226 Chromate transporter; Region: Chromate_transp; pfam02417 324602002227 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 324602002228 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 324602002229 minor groove reading motif; other site 324602002230 helix-hairpin-helix signature motif; other site 324602002231 substrate binding pocket [chemical binding]; other site 324602002232 active site 324602002233 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324602002234 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 324602002235 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; cl03741 324602002236 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 324602002237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602002238 S-adenosylmethionine binding site [chemical binding]; other site 324602002239 hypothetical protein; Provisional; Region: PRK01346 324602002240 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324602002241 Coenzyme A binding pocket [chemical binding]; other site 324602002242 Sterol carrier protein domain; Region: SCP2_2; pfam13530 324602002243 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602002244 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324602002245 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 324602002246 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 324602002247 putative active site [active] 324602002248 catalytic triad [active] 324602002249 Protein kinase domain; Region: Pkinase; pfam00069 324602002250 Catalytic domain of Protein Kinases; Region: PKc; cd00180 324602002251 active site 324602002252 ATP binding site [chemical binding]; other site 324602002253 substrate binding site [chemical binding]; other site 324602002254 activation loop (A-loop); other site 324602002255 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 324602002256 Double zinc ribbon; Region: DZR; pfam12773 324602002257 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 324602002258 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 324602002259 phosphopeptide binding site; other site 324602002260 Rb C-terminal domain; Region: Rb_C; pfam08934 324602002261 Bacterial SH3 domain; Region: SH3_3; pfam08239 324602002262 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 324602002263 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 324602002264 active site 324602002265 HIGH motif; other site 324602002266 KMSKS motif; other site 324602002267 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 324602002268 cell division protein FtsZ; Validated; Region: PRK09330 324602002269 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 324602002270 nucleotide binding site [chemical binding]; other site 324602002271 SulA interaction site; other site 324602002272 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 324602002273 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 324602002274 nucleotide binding site [chemical binding]; other site 324602002275 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 324602002276 Cell division protein FtsA; Region: FtsA; pfam14450 324602002277 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 324602002278 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 324602002279 Cell division protein FtsQ; Region: FtsQ; pfam03799 324602002280 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 324602002281 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 324602002282 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 324602002283 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14649 324602002284 FAD binding domain; Region: FAD_binding_4; pfam01565 324602002285 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 324602002286 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 324602002287 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 324602002288 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 324602002289 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 324602002290 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 324602002291 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 324602002292 active site 324602002293 homodimer interface [polypeptide binding]; other site 324602002294 cell division protein FtsW; Region: ftsW; TIGR02614 324602002295 Rhomboid family; Region: Rhomboid; pfam01694 324602002296 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 324602002297 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 324602002298 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 324602002299 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 324602002300 Mg++ binding site [ion binding]; other site 324602002301 putative catalytic motif [active] 324602002302 putative substrate binding site [chemical binding]; other site 324602002303 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 324602002304 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 324602002305 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 324602002306 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 324602002307 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 324602002308 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 324602002309 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 324602002310 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 324602002311 cell division protein MraZ; Reviewed; Region: PRK00326 324602002312 MraZ protein; Region: MraZ; pfam02381 324602002313 MraZ protein; Region: MraZ; pfam02381 324602002314 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 324602002315 trimer interface [polypeptide binding]; other site 324602002316 dimer interface [polypeptide binding]; other site 324602002317 putative active site [active] 324602002318 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 324602002319 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 324602002320 XdhC Rossmann domain; Region: XdhC_C; pfam13478 324602002321 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 324602002322 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 324602002323 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 324602002324 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 324602002325 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 324602002326 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 324602002327 Putative lysophospholipase; Region: Hydrolase_4; cl19140 324602002328 Cdc37 C terminal domain; Region: CDC37_C; cl07247 324602002329 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 324602002330 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 324602002331 metal ion-dependent adhesion site (MIDAS); other site 324602002332 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 324602002333 EamA-like transporter family; Region: EamA; pfam00892 324602002334 EamA-like transporter family; Region: EamA; pfam00892 324602002335 Bacterial transcriptional activator domain; Region: BTAD; smart01043 324602002336 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 324602002337 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 324602002338 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324602002339 Putative lysophospholipase; Region: Hydrolase_4; cl19140 324602002340 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 324602002341 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 324602002342 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 324602002343 minor groove reading motif; other site 324602002344 helix-hairpin-helix signature motif; other site 324602002345 substrate binding pocket [chemical binding]; other site 324602002346 active site 324602002347 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 324602002348 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 324602002349 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 324602002350 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 324602002351 competence damage-inducible protein A; Provisional; Region: PRK00549 324602002352 CHAT domain; Region: CHAT; pfam12770 324602002353 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 324602002354 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 324602002355 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324602002356 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602002357 TPR motif; other site 324602002358 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324602002359 binding surface 324602002360 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324602002361 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602002362 binding surface 324602002363 TPR motif; other site 324602002364 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324602002365 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602002366 binding surface 324602002367 TPR motif; other site 324602002368 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324602002369 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 324602002370 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 324602002371 peptide binding site [polypeptide binding]; other site 324602002372 dimer interface [polypeptide binding]; other site 324602002373 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 324602002374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602002375 dimer interface [polypeptide binding]; other site 324602002376 conserved gate region; other site 324602002377 putative PBP binding loops; other site 324602002378 ABC-ATPase subunit interface; other site 324602002379 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 324602002380 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 324602002381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602002382 dimer interface [polypeptide binding]; other site 324602002383 conserved gate region; other site 324602002384 putative PBP binding loops; other site 324602002385 ABC-ATPase subunit interface; other site 324602002386 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 324602002387 PLD-like domain; Region: PLDc_2; pfam13091 324602002388 putative active site [active] 324602002389 catalytic site [active] 324602002390 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 324602002391 PLD-like domain; Region: PLDc_2; pfam13091 324602002392 putative active site [active] 324602002393 catalytic site [active] 324602002394 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 324602002395 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 324602002396 peptide binding site [polypeptide binding]; other site 324602002397 dimer interface [polypeptide binding]; other site 324602002398 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 324602002399 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 324602002400 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 324602002401 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 324602002402 Walker A/P-loop; other site 324602002403 ATP binding site [chemical binding]; other site 324602002404 Q-loop/lid; other site 324602002405 ABC transporter signature motif; other site 324602002406 Walker B; other site 324602002407 D-loop; other site 324602002408 H-loop/switch region; other site 324602002409 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 324602002410 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 324602002411 Walker A/P-loop; other site 324602002412 ATP binding site [chemical binding]; other site 324602002413 Q-loop/lid; other site 324602002414 ABC transporter signature motif; other site 324602002415 Walker B; other site 324602002416 D-loop; other site 324602002417 H-loop/switch region; other site 324602002418 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 324602002419 Na binding site [ion binding]; other site 324602002420 Protoglobin; Region: Protoglobin; pfam11563 324602002421 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 324602002422 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324602002423 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 324602002424 dimerization interface [polypeptide binding]; other site 324602002425 Putative transcription activator [Transcription]; Region: TenA; COG0819 324602002426 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 324602002427 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 324602002428 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602002429 Walker A motif; other site 324602002430 ATP binding site [chemical binding]; other site 324602002431 Walker B motif; other site 324602002432 arginine finger; other site 324602002433 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 324602002434 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 324602002435 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 324602002436 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 324602002437 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 324602002438 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 324602002439 active site 324602002440 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 324602002441 active site 324602002442 phosphorylation site [posttranslational modification] 324602002443 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 324602002444 dimerization domain swap beta strand [polypeptide binding]; other site 324602002445 regulatory protein interface [polypeptide binding]; other site 324602002446 active site 324602002447 regulatory phosphorylation site [posttranslational modification]; other site 324602002448 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 324602002449 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 324602002450 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 324602002451 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 324602002452 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 324602002453 putative substrate binding site [chemical binding]; other site 324602002454 putative ATP binding site [chemical binding]; other site 324602002455 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 324602002456 active site 324602002457 P-loop; other site 324602002458 phosphorylation site [posttranslational modification] 324602002459 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 324602002460 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 324602002461 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 324602002462 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602002463 putative active site [active] 324602002464 heme pocket [chemical binding]; other site 324602002465 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602002466 dimer interface [polypeptide binding]; other site 324602002467 phosphorylation site [posttranslational modification] 324602002468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602002469 ATP binding site [chemical binding]; other site 324602002470 Mg2+ binding site [ion binding]; other site 324602002471 G-X-G motif; other site 324602002472 Predicted transcriptional regulators [Transcription]; Region: COG1378 324602002473 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 324602002474 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 324602002475 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 324602002476 dimer interface [polypeptide binding]; other site 324602002477 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 324602002478 active site 324602002479 Fe binding site [ion binding]; other site 324602002480 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 324602002481 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 324602002482 active site 324602002483 catalytic site [active] 324602002484 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 324602002485 Cu(I) binding site [ion binding]; other site 324602002486 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 324602002487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602002488 dimer interface [polypeptide binding]; other site 324602002489 conserved gate region; other site 324602002490 putative PBP binding loops; other site 324602002491 ABC-ATPase subunit interface; other site 324602002492 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 324602002493 NMT1/THI5 like; Region: NMT1; pfam09084 324602002494 AAA domain; Region: AAA_21; pfam13304 324602002495 AAA domain; Region: AAA_21; pfam13304 324602002496 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324602002497 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324602002498 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 324602002499 HlyD family secretion protein; Region: HlyD_3; pfam13437 324602002500 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324602002501 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 324602002502 Walker A/P-loop; other site 324602002503 ATP binding site [chemical binding]; other site 324602002504 Q-loop/lid; other site 324602002505 ABC transporter signature motif; other site 324602002506 Walker B; other site 324602002507 D-loop; other site 324602002508 H-loop/switch region; other site 324602002509 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 324602002510 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 324602002511 FtsX-like permease family; Region: FtsX; pfam02687 324602002512 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 324602002513 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 324602002514 FtsX-like permease family; Region: FtsX; pfam02687 324602002515 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 324602002516 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 324602002517 Helix-hairpin-helix containing domain; Region: HHH_4; pfam14490 324602002518 AAA domain; Region: AAA_30; pfam13604 324602002519 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 324602002520 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 324602002521 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 324602002522 dimerization interface [polypeptide binding]; other site 324602002523 ligand binding site [chemical binding]; other site 324602002524 NADP binding site [chemical binding]; other site 324602002525 catalytic site [active] 324602002526 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 324602002527 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 324602002528 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324602002529 Coenzyme A binding pocket [chemical binding]; other site 324602002530 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 324602002531 Cysteine-rich domain; Region: CCG; pfam02754 324602002532 Cysteine-rich domain; Region: CCG; pfam02754 324602002533 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 324602002534 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 324602002535 G1 box; other site 324602002536 putative GEF interaction site [polypeptide binding]; other site 324602002537 GTP/Mg2+ binding site [chemical binding]; other site 324602002538 Switch I region; other site 324602002539 G2 box; other site 324602002540 G3 box; other site 324602002541 Switch II region; other site 324602002542 G4 box; other site 324602002543 G5 box; other site 324602002544 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 324602002545 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 324602002546 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 324602002547 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 324602002548 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324602002549 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 324602002550 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324602002551 DNA binding residues [nucleotide binding] 324602002552 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602002553 S-adenosylmethionine binding site [chemical binding]; other site 324602002554 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324602002555 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl19151 324602002556 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 324602002557 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 324602002558 CoenzymeA binding site [chemical binding]; other site 324602002559 subunit interaction site [polypeptide binding]; other site 324602002560 PHB binding site; other site 324602002561 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 324602002562 active site 324602002563 FMN binding site [chemical binding]; other site 324602002564 substrate binding site [chemical binding]; other site 324602002565 homotetramer interface [polypeptide binding]; other site 324602002566 catalytic residue [active] 324602002567 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 324602002568 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324602002569 ATP binding site [chemical binding]; other site 324602002570 putative Mg++ binding site [ion binding]; other site 324602002571 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 324602002572 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324602002573 nucleotide binding region [chemical binding]; other site 324602002574 ATP-binding site [chemical binding]; other site 324602002575 Methyltransferase domain; Region: Methyltransf_26; pfam13659 324602002576 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 324602002577 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 324602002578 UbiA family of prenyltransferases (PTases), Unknown subgroup; Region: PT_UbiA_3; cd13965 324602002579 putative active site [active] 324602002580 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 324602002581 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 324602002582 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 324602002583 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 324602002584 Cytochrome c; Region: Cytochrom_C; pfam00034 324602002585 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 324602002586 catalytic loop [active] 324602002587 iron binding site [ion binding]; other site 324602002588 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 324602002589 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 324602002590 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602002591 S-adenosylmethionine binding site [chemical binding]; other site 324602002592 TPR repeat; Region: TPR_11; pfam13414 324602002593 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602002594 binding surface 324602002595 TPR motif; other site 324602002596 TPR repeat; Region: TPR_11; pfam13414 324602002597 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 324602002598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602002599 active site 324602002600 phosphorylation site [posttranslational modification] 324602002601 intermolecular recognition site; other site 324602002602 CheB methylesterase; Region: CheB_methylest; pfam01339 324602002603 CheW-like domain; Region: CheW; pfam01584 324602002604 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 324602002605 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 324602002606 putative binding surface; other site 324602002607 active site 324602002608 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 324602002609 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602002610 ATP binding site [chemical binding]; other site 324602002611 Mg2+ binding site [ion binding]; other site 324602002612 G-X-G motif; other site 324602002613 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 324602002614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602002615 active site 324602002616 phosphorylation site [posttranslational modification] 324602002617 intermolecular recognition site; other site 324602002618 dimerization interface [polypeptide binding]; other site 324602002619 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324602002620 dimerization interface [polypeptide binding]; other site 324602002621 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 324602002622 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 324602002623 dimer interface [polypeptide binding]; other site 324602002624 putative CheW interface [polypeptide binding]; other site 324602002625 CHASE3 domain; Region: CHASE3; cl05000 324602002626 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602002627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602002628 active site 324602002629 phosphorylation site [posttranslational modification] 324602002630 intermolecular recognition site; other site 324602002631 dimerization interface [polypeptide binding]; other site 324602002632 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 324602002633 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 324602002634 thiamine-monophosphate kinase; Region: thiL; TIGR01379 324602002635 dimerization interface [polypeptide binding]; other site 324602002636 putative ATP binding site [chemical binding]; other site 324602002637 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 324602002638 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602002639 putative active site [active] 324602002640 heme pocket [chemical binding]; other site 324602002641 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602002642 putative active site [active] 324602002643 heme pocket [chemical binding]; other site 324602002644 PAS domain S-box; Region: sensory_box; TIGR00229 324602002645 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602002646 putative active site [active] 324602002647 heme pocket [chemical binding]; other site 324602002648 PAS fold; Region: PAS_4; pfam08448 324602002649 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 324602002650 FOG: CBS domain [General function prediction only]; Region: COG0517 324602002651 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 324602002652 Glutamine cyclotransferase; Region: Glu_cyclase_2; cl19848 324602002653 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 324602002654 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 324602002655 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 324602002656 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 324602002657 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 324602002658 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 324602002659 active site 324602002660 octamer interface [polypeptide binding]; other site 324602002661 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 324602002662 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 324602002663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602002664 S-adenosylmethionine binding site [chemical binding]; other site 324602002665 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 324602002666 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 324602002667 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 324602002668 catalytic site [active] 324602002669 subunit interface [polypeptide binding]; other site 324602002670 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602002671 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 324602002672 putative ADP-binding pocket [chemical binding]; other site 324602002673 hypothetical protein; Provisional; Region: PRK06446 324602002674 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 324602002675 metal binding site [ion binding]; metal-binding site 324602002676 dimer interface [polypeptide binding]; other site 324602002677 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 324602002678 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 324602002679 metal-binding site [ion binding] 324602002680 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 324602002681 Soluble P-type ATPase [General function prediction only]; Region: COG4087 324602002682 6-phosphofructokinase, eukaryotic type; Region: 6PF1K_euk; TIGR02478 324602002683 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 324602002684 active site 324602002685 ADP/pyrophosphate binding site [chemical binding]; other site 324602002686 dimerization interface [polypeptide binding]; other site 324602002687 allosteric effector site; other site 324602002688 fructose-1,6-bisphosphate binding site; other site 324602002689 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 324602002690 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 324602002691 dimer interface [polypeptide binding]; other site 324602002692 ssDNA binding site [nucleotide binding]; other site 324602002693 tetramer (dimer of dimers) interface [polypeptide binding]; other site 324602002694 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 324602002695 AsnC family; Region: AsnC_trans_reg; pfam01037 324602002696 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 324602002697 Predicted membrane protein (DUF2206); Region: DUF2206; pfam09971 324602002698 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 324602002699 Largest subunit of RNA polymerase (RNAP), N-terminal domain; Region: RNAP_largest_subunit_N; cl19114 324602002700 Zn-binding [ion binding]; other site 324602002701 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 324602002702 beta and beta' interface [polypeptide binding]; other site 324602002703 beta' and sigma factor interface [polypeptide binding]; other site 324602002704 active site region [active] 324602002705 catalytic site [active] 324602002706 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 324602002707 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 324602002708 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 324602002709 G-loop; other site 324602002710 DNA binding site [nucleotide binding] 324602002711 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 324602002712 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 324602002713 RPB12 interaction site [polypeptide binding]; other site 324602002714 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478 324602002715 RPB1 interaction site [polypeptide binding]; other site 324602002716 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 324602002717 RPB10 interaction site [polypeptide binding]; other site 324602002718 Peptidase family M23; Region: Peptidase_M23; pfam01551 324602002719 RPB11 interaction site [polypeptide binding]; other site 324602002720 RPB3 interaction site [polypeptide binding]; other site 324602002721 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324602002722 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324602002723 dimerization interface [polypeptide binding]; other site 324602002724 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602002725 dimer interface [polypeptide binding]; other site 324602002726 phosphorylation site [posttranslational modification] 324602002727 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602002728 ATP binding site [chemical binding]; other site 324602002729 Mg2+ binding site [ion binding]; other site 324602002730 G-X-G motif; other site 324602002731 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602002732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602002733 active site 324602002734 phosphorylation site [posttranslational modification] 324602002735 intermolecular recognition site; other site 324602002736 dimerization interface [polypeptide binding]; other site 324602002737 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324602002738 DNA binding site [nucleotide binding] 324602002739 hypothetical protein; Provisional; Region: PRK06148 324602002740 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 324602002741 active site 324602002742 ATP binding site [chemical binding]; other site 324602002743 Peptidase family M23; Region: Peptidase_M23; pfam01551 324602002744 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 324602002745 inhibitor-cofactor binding pocket; inhibition site 324602002746 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602002747 catalytic residue [active] 324602002748 BDLF3; Provisional; Region: PHA03255 324602002749 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 324602002750 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 324602002751 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 324602002752 Ca binding site [ion binding]; other site 324602002753 active site 324602002754 catalytic site [active] 324602002755 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 324602002756 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 324602002757 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 324602002758 active site 324602002759 Ca binding site [ion binding]; other site 324602002760 catalytic site [active] 324602002761 Aamy_C domain; Region: Aamy_C; smart00632 324602002762 mevalonate kinase; Region: mevalon_kin; TIGR00549 324602002763 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 324602002764 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 324602002765 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 324602002766 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 324602002767 putative tRNA-binding site [nucleotide binding]; other site 324602002768 B3/4 domain; Region: B3_4; pfam03483 324602002769 tRNA synthetase B5 domain; Region: B5; smart00874 324602002770 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 324602002771 dimer interface [polypeptide binding]; other site 324602002772 motif 1; other site 324602002773 motif 3; other site 324602002774 motif 2; other site 324602002775 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 324602002776 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 324602002777 Protein of unknown function (DUF390); Region: DUF390; pfam04094 324602002778 cell division protein MraZ; Reviewed; Region: PRK00326 324602002779 MraZ protein; Region: MraZ; pfam02381 324602002780 MraZ protein; Region: MraZ; pfam02381 324602002781 CHAT domain; Region: CHAT; pfam12770 324602002782 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 324602002783 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 324602002784 amidase catalytic site [active] 324602002785 Zn binding residues [ion binding]; other site 324602002786 substrate binding site [chemical binding]; other site 324602002787 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 324602002788 cell division protein FtsZ; Region: ftsZ; TIGR00065 324602002789 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 324602002790 nucleotide binding site [chemical binding]; other site 324602002791 SulA interaction site; other site 324602002792 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 324602002793 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 324602002794 DXD motif; other site 324602002795 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324602002796 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602002797 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602002798 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324602002799 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 324602002800 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 324602002801 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 324602002802 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 324602002803 dimerization interface [polypeptide binding]; other site 324602002804 active site 324602002805 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 324602002806 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324602002807 ligand binding site [chemical binding]; other site 324602002808 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324602002809 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602002810 dimer interface [polypeptide binding]; other site 324602002811 phosphorylation site [posttranslational modification] 324602002812 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602002813 ATP binding site [chemical binding]; other site 324602002814 Mg2+ binding site [ion binding]; other site 324602002815 G-X-G motif; other site 324602002816 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602002817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602002818 active site 324602002819 phosphorylation site [posttranslational modification] 324602002820 intermolecular recognition site; other site 324602002821 dimerization interface [polypeptide binding]; other site 324602002822 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324602002823 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324602002824 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324602002825 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 324602002826 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 324602002827 Uncharacterized conserved protein [Function unknown]; Region: COG1262 324602002828 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; cl19582 324602002829 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 324602002830 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 324602002831 GAF domain; Region: GAF_3; pfam13492 324602002832 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 324602002833 Histidine kinase; Region: HisKA_3; pfam07730 324602002834 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602002835 ATP binding site [chemical binding]; other site 324602002836 Mg2+ binding site [ion binding]; other site 324602002837 G-X-G motif; other site 324602002838 malate dehydrogenase, NAD-dependent; Region: MalateDH_bact; TIGR01763 324602002839 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 324602002840 NAD(P) binding site [chemical binding]; other site 324602002841 dimer interface [polypeptide binding]; other site 324602002842 tetramer (dimer of dimers) interface [polypeptide binding]; other site 324602002843 substrate binding site [chemical binding]; other site 324602002844 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 324602002845 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 324602002846 RNA binding surface [nucleotide binding]; other site 324602002847 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 324602002848 active site 324602002849 lipoprotein signal peptidase; Provisional; Region: PRK14789 324602002850 lipoprotein signal peptidase; Provisional; Region: PRK14790 324602002851 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 324602002852 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 324602002853 P-loop; other site 324602002854 Magnesium ion binding site [ion binding]; other site 324602002855 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 324602002856 Walker A motif; other site 324602002857 ATP binding site [chemical binding]; other site 324602002858 Walker B motif; other site 324602002859 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 324602002860 TadE-like protein; Region: TadE; pfam07811 324602002861 Cna protein B-type domain; Region: Cna_B; pfam05738 324602002862 Domain of unknown function DUF11; Region: DUF11; cl17728 324602002863 Domain of unknown function DUF11; Region: DUF11; pfam01345 324602002864 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 324602002865 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 324602002866 active site 324602002867 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 324602002868 phosphopeptide binding site; other site 324602002869 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 324602002870 Methyltransferase domain; Region: Methyltransf_31; pfam13847 324602002871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602002872 S-adenosylmethionine binding site [chemical binding]; other site 324602002873 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602002874 S-adenosylmethionine binding site [chemical binding]; other site 324602002875 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 324602002876 FOG: CBS domain [General function prediction only]; Region: COG0517 324602002877 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 324602002878 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 324602002879 RibD C-terminal domain; Region: RibD_C; cl17279 324602002880 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 324602002881 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324602002882 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324602002883 DNA binding residues [nucleotide binding] 324602002884 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 324602002885 Putative zinc-finger; Region: zf-HC2; pfam13490 324602002886 UGMP family protein; Validated; Region: PRK09604 324602002887 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 324602002888 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 324602002889 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 324602002890 catalytic residue [active] 324602002891 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 324602002892 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 324602002893 dimerization interface [polypeptide binding]; other site 324602002894 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 324602002895 ligand binding site [chemical binding]; other site 324602002896 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 324602002897 dimerization interface [polypeptide binding]; other site 324602002898 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 324602002899 ligand binding site [chemical binding]; other site 324602002900 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 324602002901 TM-ABC transporter signature motif; other site 324602002902 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 324602002903 TM-ABC transporter signature motif; other site 324602002904 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 324602002905 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 324602002906 Walker A/P-loop; other site 324602002907 ATP binding site [chemical binding]; other site 324602002908 Q-loop/lid; other site 324602002909 ABC transporter signature motif; other site 324602002910 Walker B; other site 324602002911 D-loop; other site 324602002912 H-loop/switch region; other site 324602002913 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 324602002914 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 324602002915 Walker A/P-loop; other site 324602002916 ATP binding site [chemical binding]; other site 324602002917 Q-loop/lid; other site 324602002918 ABC transporter signature motif; other site 324602002919 Walker B; other site 324602002920 D-loop; other site 324602002921 H-loop/switch region; other site 324602002922 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602002923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602002924 active site 324602002925 phosphorylation site [posttranslational modification] 324602002926 intermolecular recognition site; other site 324602002927 dimerization interface [polypeptide binding]; other site 324602002928 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324602002929 DNA binding site [nucleotide binding] 324602002930 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 324602002931 DnaJ domain; Region: DnaJ; pfam00226 324602002932 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 324602002933 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 324602002934 catalytic residues [active] 324602002935 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 324602002936 HSP70 interaction site [polypeptide binding]; other site 324602002937 TPR repeat; Region: TPR_11; pfam13414 324602002938 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602002939 binding surface 324602002940 TPR motif; other site 324602002941 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 324602002942 CcmE; Region: CcmE; cl00994 324602002943 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 324602002944 CcmB protein; Region: CcmB; cl17444 324602002945 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324602002946 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 324602002947 Walker A/P-loop; other site 324602002948 ATP binding site [chemical binding]; other site 324602002949 Q-loop/lid; other site 324602002950 ABC transporter signature motif; other site 324602002951 Walker B; other site 324602002952 D-loop; other site 324602002953 H-loop/switch region; other site 324602002954 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 324602002955 active site 324602002956 oxyanion hole [active] 324602002957 catalytic triad [active] 324602002958 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 324602002959 CoA-binding domain; Region: CoA_binding_3; pfam13727 324602002960 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 324602002961 NAD(P) binding site [chemical binding]; other site 324602002962 homodimer interface [polypeptide binding]; other site 324602002963 substrate binding site [chemical binding]; other site 324602002964 active site 324602002965 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 324602002966 inhibitor-cofactor binding pocket; inhibition site 324602002967 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602002968 catalytic residue [active] 324602002969 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 324602002970 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 324602002971 putative trimer interface [polypeptide binding]; other site 324602002972 putative CoA binding site [chemical binding]; other site 324602002973 Bacterial sugar transferase; Region: Bac_transf; pfam02397 324602002974 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 324602002975 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 324602002976 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 324602002977 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 324602002978 replicative DNA helicase; Region: DnaB; TIGR00665 324602002979 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 324602002980 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 324602002981 Walker A motif; other site 324602002982 ATP binding site [chemical binding]; other site 324602002983 Walker B motif; other site 324602002984 DNA binding loops [nucleotide binding] 324602002985 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 324602002986 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 324602002987 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 324602002988 dimer interface [polypeptide binding]; other site 324602002989 PYR/PP interface [polypeptide binding]; other site 324602002990 TPP binding site [chemical binding]; other site 324602002991 substrate binding site [chemical binding]; other site 324602002992 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 324602002993 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 324602002994 TPP-binding site [chemical binding]; other site 324602002995 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 324602002996 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 324602002997 NAD(P) binding site [chemical binding]; other site 324602002998 catalytic residues [active] 324602002999 Fe-S metabolizm associated domain; Region: SufE; cl00951 324602003000 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602003001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602003002 active site 324602003003 phosphorylation site [posttranslational modification] 324602003004 intermolecular recognition site; other site 324602003005 dimerization interface [polypeptide binding]; other site 324602003006 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324602003007 DNA binding site [nucleotide binding] 324602003008 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 324602003009 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602003010 dimer interface [polypeptide binding]; other site 324602003011 phosphorylation site [posttranslational modification] 324602003012 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602003013 ATP binding site [chemical binding]; other site 324602003014 Mg2+ binding site [ion binding]; other site 324602003015 G-X-G motif; other site 324602003016 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324602003017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602003018 active site 324602003019 phosphorylation site [posttranslational modification] 324602003020 intermolecular recognition site; other site 324602003021 dimerization interface [polypeptide binding]; other site 324602003022 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 324602003023 G1 box; other site 324602003024 GTP/Mg2+ binding site [chemical binding]; other site 324602003025 G2 box; other site 324602003026 Switch I region; other site 324602003027 G3 box; other site 324602003028 Switch II region; other site 324602003029 G4 box; other site 324602003030 G5 box; other site 324602003031 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602003032 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324602003033 Colicin V production protein; Region: Colicin_V; pfam02674 324602003034 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 324602003035 PrkA AAA domain; Region: AAA_PrkA; smart00763 324602003036 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 324602003037 hypothetical protein; Provisional; Region: PRK05325 324602003038 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 324602003039 metal ion-dependent adhesion site (MIDAS); other site 324602003040 SpoVR like protein; Region: SpoVR; cl19504 324602003041 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 324602003042 protein-splicing catalytic site; other site 324602003043 thioester formation/cholesterol transfer; other site 324602003044 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 324602003045 SpoVR like protein; Region: SpoVR; cl19504 324602003046 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 324602003047 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 324602003048 Walker A/P-loop; other site 324602003049 ATP binding site [chemical binding]; other site 324602003050 Q-loop/lid; other site 324602003051 ABC transporter signature motif; other site 324602003052 Walker B; other site 324602003053 D-loop; other site 324602003054 H-loop/switch region; other site 324602003055 Bacterial PH domain; Region: bPH_2; cl01348 324602003056 cytidylate kinase; Provisional; Region: cmk; PRK00023 324602003057 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 324602003058 CMP-binding site; other site 324602003059 The sites determining sugar specificity; other site 324602003060 GMP synthase; Reviewed; Region: guaA; PRK00074 324602003061 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 324602003062 AMP/PPi binding site [chemical binding]; other site 324602003063 candidate oxyanion hole; other site 324602003064 catalytic triad [active] 324602003065 potential glutamine specificity residues [chemical binding]; other site 324602003066 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 324602003067 ATP Binding subdomain [chemical binding]; other site 324602003068 Ligand Binding sites [chemical binding]; other site 324602003069 Dimerization subdomain; other site 324602003070 Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221 324602003071 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 324602003072 active sites [active] 324602003073 tetramer interface [polypeptide binding]; other site 324602003074 imidazolonepropionase; Validated; Region: PRK09356 324602003075 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 324602003076 active site 324602003077 urocanate hydratase; Provisional; Region: PRK05414 324602003078 ABC-2 type transporter; Region: ABC2_membrane; cl17235 324602003079 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 324602003080 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 324602003081 Soluble P-type ATPase [General function prediction only]; Region: COG4087 324602003082 multicopper oxidase; Provisional; Region: PRK10965 324602003083 The first cupredoxin domain of multicopper oxidase McoP and similar proteins; Region: CuRO_1_McoP_like; cd13852 324602003084 Domain 2 interface [polypeptide binding]; other site 324602003085 Domain 3 interface [polypeptide binding]; other site 324602003086 trinuclear Cu binding site [ion binding]; other site 324602003087 The second cupredoxin domain of multicopper oxidase McoP and similar proteins; Region: CuRO_2_McoP_like; cd13879 324602003088 putative Domain 1 interface [polypeptide binding]; other site 324602003089 putative Domain 3 interface [polypeptide binding]; other site 324602003090 The third cupredoxin domain of uncharacterized multicopper oxidase; Region: CuRO_3_MCO_like_1; cd13907 324602003091 putative Domain 2 interface [polypeptide binding]; other site 324602003092 Type 1 (T1) Cu binding site [ion binding]; other site 324602003093 putative Domain 1 interface [polypeptide binding]; other site 324602003094 trinuclear Cu binding site [ion binding]; other site 324602003095 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 324602003096 Alkyl sulfatase dimerization; Region: Alkyl_sulf_dimr; pfam14863 324602003097 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 324602003098 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 324602003099 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 324602003100 N-acetyl-D-glucosamine binding site [chemical binding]; other site 324602003101 catalytic residue [active] 324602003102 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324602003103 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602003104 MoxR-like ATPases [General function prediction only]; Region: COG0714 324602003105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602003106 Walker A motif; other site 324602003107 ATP binding site [chemical binding]; other site 324602003108 Walker B motif; other site 324602003109 arginine finger; other site 324602003110 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 324602003111 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 324602003112 Probable Catalytic site; other site 324602003113 DNA methylase; Region: N6_N4_Mtase; pfam01555 324602003114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602003115 S-adenosylmethionine binding site [chemical binding]; other site 324602003116 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 324602003117 Fe-S cluster binding site [ion binding]; other site 324602003118 active site 324602003119 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 324602003120 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 324602003121 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 324602003122 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 324602003123 trimer interface [polypeptide binding]; other site 324602003124 active site 324602003125 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 324602003126 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602003127 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 324602003128 active site 324602003129 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 324602003130 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324602003131 catalytic residue [active] 324602003132 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 324602003133 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 324602003134 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 324602003135 Bacterial SH3 domain; Region: SH3_3; pfam08239 324602003136 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 324602003137 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 324602003138 FtsX-like permease family; Region: FtsX; pfam02687 324602003139 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324602003140 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 324602003141 Walker A/P-loop; other site 324602003142 ATP binding site [chemical binding]; other site 324602003143 Q-loop/lid; other site 324602003144 ABC transporter signature motif; other site 324602003145 Walker B; other site 324602003146 D-loop; other site 324602003147 H-loop/switch region; other site 324602003148 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 324602003149 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 324602003150 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 324602003151 HlyD family secretion protein; Region: HlyD_3; pfam13437 324602003152 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324602003153 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324602003154 Probable zinc-binding domain; Region: zf-trcl; pfam13451 324602003155 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 324602003156 ammonium transporter; Region: amt; TIGR00836 324602003157 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 324602003158 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 324602003159 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 324602003160 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 324602003161 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 324602003162 Putative lysophospholipase; Region: Hydrolase_4; cl19140 324602003163 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 324602003164 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 324602003165 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 324602003166 hypothetical protein; Provisional; Region: PRK06446 324602003167 metal binding site [ion binding]; metal-binding site 324602003168 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 324602003169 anti sigma factor interaction site; other site 324602003170 regulatory phosphorylation site [posttranslational modification]; other site 324602003171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602003172 ATP binding site [chemical binding]; other site 324602003173 Mg2+ binding site [ion binding]; other site 324602003174 G-X-G motif; other site 324602003175 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 324602003176 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 324602003177 ligand binding site [chemical binding]; other site 324602003178 flexible hinge region; other site 324602003179 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 324602003180 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 324602003181 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 324602003182 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 324602003183 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 324602003184 active site 324602003185 PHP Thumb interface [polypeptide binding]; other site 324602003186 metal binding site [ion binding]; metal-binding site 324602003187 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 324602003188 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 324602003189 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 324602003190 generic binding surface II; other site 324602003191 generic binding surface I; other site 324602003192 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 324602003193 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 324602003194 putative [4Fe-4S] binding site [ion binding]; other site 324602003195 putative molybdopterin cofactor binding site [chemical binding]; other site 324602003196 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 324602003197 putative molybdopterin cofactor binding site; other site 324602003198 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 324602003199 Protein of unknown function (DUF2012); Region: DUF2012; pfam09430 324602003200 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 324602003201 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 324602003202 Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635 324602003203 seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474 324602003204 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 324602003205 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 324602003206 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324602003207 catalytic residue [active] 324602003208 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 324602003209 Ligand binding site; other site 324602003210 metal-binding site 324602003211 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 324602003212 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 324602003213 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 324602003214 dimer interface [polypeptide binding]; other site 324602003215 ssDNA binding site [nucleotide binding]; other site 324602003216 tetramer (dimer of dimers) interface [polypeptide binding]; other site 324602003217 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 324602003218 Bacterial PH domain; Region: bPH_5; pfam10882 324602003219 PT repeat; Region: PT; pfam04886 324602003220 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 324602003221 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 324602003222 peptide binding site [polypeptide binding]; other site 324602003223 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 324602003224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602003225 dimer interface [polypeptide binding]; other site 324602003226 conserved gate region; other site 324602003227 putative PBP binding loops; other site 324602003228 ABC-ATPase subunit interface; other site 324602003229 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 324602003230 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 324602003231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602003232 dimer interface [polypeptide binding]; other site 324602003233 conserved gate region; other site 324602003234 putative PBP binding loops; other site 324602003235 ABC-ATPase subunit interface; other site 324602003236 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 324602003237 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 324602003238 active site 324602003239 Predicted acyl esterases [General function prediction only]; Region: COG2936 324602003240 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 324602003241 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 324602003242 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 324602003243 Clp amino terminal domain; Region: Clp_N; pfam02861 324602003244 Clp amino terminal domain; Region: Clp_N; pfam02861 324602003245 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602003246 Walker A motif; other site 324602003247 ATP binding site [chemical binding]; other site 324602003248 Walker B motif; other site 324602003249 arginine finger; other site 324602003250 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602003251 Walker A motif; other site 324602003252 ATP binding site [chemical binding]; other site 324602003253 Walker B motif; other site 324602003254 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 324602003255 GAF domain; Region: GAF; cl17456 324602003256 GAF domain; Region: GAF; pfam01590 324602003257 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 324602003258 RNA/DNA hybrid binding site [nucleotide binding]; other site 324602003259 active site 324602003260 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602003261 S-adenosylmethionine binding site [chemical binding]; other site 324602003262 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 324602003263 Double zinc ribbon; Region: DZR; pfam12773 324602003264 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 324602003265 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 324602003266 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 324602003267 ligand binding site [chemical binding]; other site 324602003268 flexible hinge region; other site 324602003269 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 324602003270 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 324602003271 ligand binding site [chemical binding]; other site 324602003272 flexible hinge region; other site 324602003273 hypothetical protein; Validated; Region: PRK00110 324602003274 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 324602003275 active site 324602003276 putative DNA-binding cleft [nucleotide binding]; other site 324602003277 dimer interface [polypeptide binding]; other site 324602003278 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 324602003279 cyclase homology domain; Region: CHD; cd07302 324602003280 nucleotidyl binding site; other site 324602003281 metal binding site [ion binding]; metal-binding site 324602003282 dimer interface [polypeptide binding]; other site 324602003283 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 324602003284 cyclase homology domain; Region: CHD; cd07302 324602003285 nucleotidyl binding site; other site 324602003286 dimer interface [polypeptide binding]; other site 324602003287 metal binding site [ion binding]; metal-binding site 324602003288 Predicted ATPase [General function prediction only]; Region: COG3899 324602003289 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602003290 Walker A motif; other site 324602003291 ATP binding site [chemical binding]; other site 324602003292 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 324602003293 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 324602003294 peptide binding site [polypeptide binding]; other site 324602003295 adhesin; Provisional; Region: PRK09752 324602003296 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602003297 S-adenosylmethionine binding site [chemical binding]; other site 324602003298 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 324602003299 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 324602003300 ABC transporter; Region: ABC_tran_2; pfam12848 324602003301 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 324602003302 Subunit M of bacterial photosynthetic reaction center; Region: Photo-RC_M; cd09291 324602003303 subunit H interface; other site 324602003304 subunit L interface; other site 324602003305 bacteriopheophytin binding site; other site 324602003306 carotenoid binding site; other site 324602003307 bacteriochlorophyll binding site; other site 324602003308 cytochrome C interface; other site 324602003309 quinone binding site; other site 324602003310 Fe binding site [ion binding]; other site 324602003311 Subunit L of bacterial photosynthetic reaction center; Region: Photo-RC_L; cd09290 324602003312 subunit M interface; other site 324602003313 subunit H interface; other site 324602003314 quinone binding site; other site 324602003315 bacteriopheophytin binding site; other site 324602003316 bacteriochlorophyll binding site; other site 324602003317 cytochrome C subunit interface; other site 324602003318 Fe binding site [ion binding]; other site 324602003319 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 324602003320 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 324602003321 Probable Catalytic site; other site 324602003322 metal-binding site 324602003323 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 324602003324 CoA-binding domain; Region: CoA_binding_3; pfam13727 324602003325 Bacterial sugar transferase; Region: Bac_transf; pfam02397 324602003326 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 324602003327 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 324602003328 VanW like protein; Region: VanW; pfam04294 324602003329 G5 domain; Region: G5; pfam07501 324602003330 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 324602003331 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 324602003332 AP (apurinic/apyrimidinic) site pocket; other site 324602003333 DNA interaction; other site 324602003334 Metal-binding active site; metal-binding site 324602003335 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 324602003336 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 324602003337 Esterase/lipase [General function prediction only]; Region: COG1647 324602003338 Putative lysophospholipase; Region: Hydrolase_4; cl19140 324602003339 GAF domain; Region: GAF_2; pfam13185 324602003340 GAF domain; Region: GAF_2; pfam13185 324602003341 GAF domain; Region: GAF; pfam01590 324602003342 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 324602003343 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 324602003344 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602003345 ATP binding site [chemical binding]; other site 324602003346 Mg2+ binding site [ion binding]; other site 324602003347 G-X-G motif; other site 324602003348 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 324602003349 anti sigma factor interaction site; other site 324602003350 regulatory phosphorylation site [posttranslational modification]; other site 324602003351 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 324602003352 anti sigma factor interaction site; other site 324602003353 regulatory phosphorylation site [posttranslational modification]; other site 324602003354 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 324602003355 Protein of unknown function (DUF541); Region: SIMPL; cl01077 324602003356 excinuclease ABC subunit B; Provisional; Region: PRK05298 324602003357 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324602003358 ATP binding site [chemical binding]; other site 324602003359 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324602003360 nucleotide binding region [chemical binding]; other site 324602003361 ATP-binding site [chemical binding]; other site 324602003362 Ultra-violet resistance protein B; Region: UvrB; pfam12344 324602003363 UvrB/uvrC motif; Region: UVR; pfam02151 324602003364 Nuclease-related domain; Region: NERD; pfam08378 324602003365 Reovirus core-spike protein lambda-2 (L2); Region: Reovirus_L2; pfam06016 324602003366 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 324602003367 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 324602003368 hydrophobic ligand binding site; other site 324602003369 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 324602003370 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 324602003371 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 324602003372 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 324602003373 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324602003374 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 324602003375 sequence-specific DNA binding site [nucleotide binding]; other site 324602003376 salt bridge; other site 324602003377 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12858 324602003378 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 324602003379 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 324602003380 acyl-activating enzyme (AAE) consensus motif; other site 324602003381 putative AMP binding site [chemical binding]; other site 324602003382 putative active site [active] 324602003383 putative CoA binding site [chemical binding]; other site 324602003384 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 324602003385 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 324602003386 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 324602003387 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; cl08459 324602003388 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 324602003389 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 324602003390 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 324602003391 active site 324602003392 catalytic residues [active] 324602003393 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 324602003394 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 324602003395 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324602003396 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602003397 dimer interface [polypeptide binding]; other site 324602003398 conserved gate region; other site 324602003399 putative PBP binding loops; other site 324602003400 ABC-ATPase subunit interface; other site 324602003401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602003402 putative PBP binding loops; other site 324602003403 dimer interface [polypeptide binding]; other site 324602003404 ABC-ATPase subunit interface; other site 324602003405 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324602003406 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324602003407 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 324602003408 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 324602003409 acyl-activating enzyme (AAE) consensus motif; other site 324602003410 active site 324602003411 AMP binding site [chemical binding]; other site 324602003412 CoA binding site [chemical binding]; other site 324602003413 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 324602003414 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 324602003415 Walker A/P-loop; other site 324602003416 ATP binding site [chemical binding]; other site 324602003417 Q-loop/lid; other site 324602003418 ABC transporter signature motif; other site 324602003419 Walker B; other site 324602003420 D-loop; other site 324602003421 H-loop/switch region; other site 324602003422 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 324602003423 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 324602003424 putative ligand binding site [chemical binding]; other site 324602003425 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 324602003426 TM-ABC transporter signature motif; other site 324602003427 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 324602003428 TM-ABC transporter signature motif; other site 324602003429 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 324602003430 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 324602003431 acyl-activating enzyme (AAE) consensus motif; other site 324602003432 putative AMP binding site [chemical binding]; other site 324602003433 putative active site [active] 324602003434 putative CoA binding site [chemical binding]; other site 324602003435 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 324602003436 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 324602003437 Walker A/P-loop; other site 324602003438 ATP binding site [chemical binding]; other site 324602003439 Q-loop/lid; other site 324602003440 ABC transporter signature motif; other site 324602003441 Walker B; other site 324602003442 D-loop; other site 324602003443 H-loop/switch region; other site 324602003444 AAK_NAGK-UC: N-Acetyl-L-glutamate kinase - uncharacterized (NAGK-UC). This domain is similar to Escherichia coli and Pseudomonas aeruginosa NAGKs which catalyze the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the...; Region: AAK_NAGK-UC; cd04251 324602003445 putative nucleotide binding site [chemical binding]; other site 324602003446 putative N-acetyl-L-glutamate binding site [chemical binding]; other site 324602003447 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 324602003448 active site 324602003449 metal binding site [ion binding]; metal-binding site 324602003450 uncharacterized subgroup of the Peptidase C25 family N-terminal domain; Region: Peptidase_C25_N_1; cd10914 324602003451 putative active site [active] 324602003452 Domain of unknown function DUF11; Region: DUF11; pfam01345 324602003453 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 324602003454 Domain of unknown function DUF11; Region: DUF11; cl17728 324602003455 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 324602003456 Domain of unknown function DUF11; Region: DUF11; pfam01345 324602003457 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 324602003458 Domain of unknown function DUF11; Region: DUF11; pfam01345 324602003459 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 324602003460 Domain of unknown function DUF11; Region: DUF11; pfam01345 324602003461 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 324602003462 Domain of unknown function DUF11; Region: DUF11; pfam01345 324602003463 Domain of unknown function DUF11; Region: DUF11; pfam01345 324602003464 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324602003465 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 324602003466 HYR domain; Region: HYR; pfam02494 324602003467 HYR domain; Region: HYR; pfam02494 324602003468 HYR domain; Region: HYR; pfam02494 324602003469 HYR domain; Region: HYR; pfam02494 324602003470 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 324602003471 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl19174 324602003472 NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NuoL; COG1009 324602003473 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 324602003474 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 324602003475 Walker A/P-loop; other site 324602003476 ATP binding site [chemical binding]; other site 324602003477 Q-loop/lid; other site 324602003478 ABC transporter signature motif; other site 324602003479 Walker B; other site 324602003480 D-loop; other site 324602003481 H-loop/switch region; other site 324602003482 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 324602003483 Peptidase family M23; Region: Peptidase_M23; pfam01551 324602003484 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 324602003485 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 324602003486 dimer interface [polypeptide binding]; other site 324602003487 active site 324602003488 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 324602003489 catalytic residues [active] 324602003490 substrate binding site [chemical binding]; other site 324602003491 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 324602003492 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 324602003493 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 324602003494 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 324602003495 dimerization interface [polypeptide binding]; other site 324602003496 putative active cleft [active] 324602003497 Protein of unknown function (DUF4127); Region: DUF4127; pfam13552 324602003498 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324602003499 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324602003500 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 324602003501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602003502 conserved gate region; other site 324602003503 dimer interface [polypeptide binding]; other site 324602003504 putative PBP binding loops; other site 324602003505 ABC-ATPase subunit interface; other site 324602003506 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324602003507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602003508 dimer interface [polypeptide binding]; other site 324602003509 conserved gate region; other site 324602003510 putative PBP binding loops; other site 324602003511 ABC-ATPase subunit interface; other site 324602003512 alpha-mannosidase; Provisional; Region: PRK09819 324602003513 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 324602003514 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 324602003515 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 324602003516 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 324602003517 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 324602003518 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 324602003519 dimer interface [polypeptide binding]; other site 324602003520 active site 324602003521 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 324602003522 dimer interface [polypeptide binding]; other site 324602003523 active site 324602003524 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 324602003525 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 324602003526 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 324602003527 putative NAD(P) binding site [chemical binding]; other site 324602003528 catalytic Zn binding site [ion binding]; other site 324602003529 structural Zn binding site [ion binding]; other site 324602003530 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 324602003531 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 324602003532 NADP binding site [chemical binding]; other site 324602003533 active site 324602003534 putative substrate binding site [chemical binding]; other site 324602003535 ribonuclease III; Reviewed; Region: rnc; PRK00102 324602003536 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 324602003537 dimerization interface [polypeptide binding]; other site 324602003538 active site 324602003539 metal binding site [ion binding]; metal-binding site 324602003540 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 324602003541 dsRNA binding site [nucleotide binding]; other site 324602003542 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 324602003543 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 324602003544 dimer interface [polypeptide binding]; other site 324602003545 active site 324602003546 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 324602003547 Peptidase family M50; Region: Peptidase_M50; pfam02163 324602003548 active site 324602003549 putative substrate binding region [chemical binding]; other site 324602003550 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 324602003551 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 324602003552 NADP-binding site; other site 324602003553 homotetramer interface [polypeptide binding]; other site 324602003554 substrate binding site [chemical binding]; other site 324602003555 homodimer interface [polypeptide binding]; other site 324602003556 active site 324602003557 transcriptional repressor DicA; Reviewed; Region: PRK09706 324602003558 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324602003559 non-specific DNA binding site [nucleotide binding]; other site 324602003560 salt bridge; other site 324602003561 sequence-specific DNA binding site [nucleotide binding]; other site 324602003562 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 324602003563 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 324602003564 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 324602003565 CoA-ligase; Region: Ligase_CoA; pfam00549 324602003566 CTP synthetase; Validated; Region: pyrG; PRK05380 324602003567 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 324602003568 Catalytic site [active] 324602003569 active site 324602003570 UTP binding site [chemical binding]; other site 324602003571 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 324602003572 active site 324602003573 putative oxyanion hole; other site 324602003574 catalytic triad [active] 324602003575 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 324602003576 RecX family; Region: RecX; cl00936 324602003577 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 324602003578 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 324602003579 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 324602003580 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 324602003581 phosphopeptide binding site; other site 324602003582 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 324602003583 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 324602003584 cyclase homology domain; Region: CHD; cd07302 324602003585 nucleotidyl binding site; other site 324602003586 metal binding site [ion binding]; metal-binding site 324602003587 dimer interface [polypeptide binding]; other site 324602003588 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 324602003589 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 324602003590 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 324602003591 E3 Ubiquitin ligase; Region: GIDE; pfam12483 324602003592 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_8; cd06905 324602003593 putative active site [active] 324602003594 Zn binding site [ion binding]; other site 324602003595 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 324602003596 active site 324602003597 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 324602003598 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602003599 ATP binding site [chemical binding]; other site 324602003600 Mg2+ binding site [ion binding]; other site 324602003601 G-X-G motif; other site 324602003602 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 324602003603 ATP binding site [chemical binding]; other site 324602003604 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 324602003605 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 324602003606 DHH family; Region: DHH; pfam01368 324602003607 DHHA1 domain; Region: DHHA1; pfam02272 324602003608 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 324602003609 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324602003610 dimerization interface [polypeptide binding]; other site 324602003611 GAF domain; Region: GAF_3; pfam13492 324602003612 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324602003613 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602003614 dimer interface [polypeptide binding]; other site 324602003615 phosphorylation site [posttranslational modification] 324602003616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602003617 ATP binding site [chemical binding]; other site 324602003618 G-X-G motif; other site 324602003619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602003620 active site 324602003621 phosphorylation site [posttranslational modification] 324602003622 intermolecular recognition site; other site 324602003623 dimerization interface [polypeptide binding]; other site 324602003624 Tetratricopeptide repeat; Region: TPR_19; pfam14559 324602003625 Probable zinc-binding domain; Region: zf-trcl; pfam13451 324602003626 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324602003627 metal binding site [ion binding]; metal-binding site 324602003628 active site 324602003629 I-site; other site 324602003630 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 324602003631 phosphoglyceromutase; Provisional; Region: PRK05434 324602003632 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 324602003633 FAD binding domain; Region: FAD_binding_4; pfam01565 324602003634 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 324602003635 FAD binding domain; Region: FAD_binding_4; pfam01565 324602003636 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 324602003637 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 324602003638 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 324602003639 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 324602003640 Ligand binding site; other site 324602003641 Putative Catalytic site; other site 324602003642 DXD motif; other site 324602003643 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 324602003644 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 324602003645 ligand binding site [chemical binding]; other site 324602003646 flexible hinge region; other site 324602003647 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 324602003648 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 324602003649 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 324602003650 peptide binding site [polypeptide binding]; other site 324602003651 dimer interface [polypeptide binding]; other site 324602003652 AAA ATPase domain; Region: AAA_16; pfam13191 324602003653 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 324602003654 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 324602003655 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 324602003656 Walker A/P-loop; other site 324602003657 ATP binding site [chemical binding]; other site 324602003658 Q-loop/lid; other site 324602003659 ABC transporter signature motif; other site 324602003660 Walker B; other site 324602003661 D-loop; other site 324602003662 H-loop/switch region; other site 324602003663 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 324602003664 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 324602003665 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 324602003666 Walker A/P-loop; other site 324602003667 ATP binding site [chemical binding]; other site 324602003668 Q-loop/lid; other site 324602003669 ABC transporter signature motif; other site 324602003670 Walker B; other site 324602003671 D-loop; other site 324602003672 H-loop/switch region; other site 324602003673 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 324602003674 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 324602003675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602003676 dimer interface [polypeptide binding]; other site 324602003677 conserved gate region; other site 324602003678 putative PBP binding loops; other site 324602003679 ABC-ATPase subunit interface; other site 324602003680 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 324602003681 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602003682 dimer interface [polypeptide binding]; other site 324602003683 conserved gate region; other site 324602003684 putative PBP binding loops; other site 324602003685 ABC-ATPase subunit interface; other site 324602003686 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 324602003687 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 324602003688 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 324602003689 substrate binding site [chemical binding]; other site 324602003690 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324602003691 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324602003692 DNA binding site [nucleotide binding] 324602003693 domain linker motif; other site 324602003694 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324602003695 dimerization interface [polypeptide binding]; other site 324602003696 ligand binding site [chemical binding]; other site 324602003697 Uncharacterized conserved protein [Function unknown]; Region: COG3375 324602003698 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 324602003699 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 324602003700 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 324602003701 active site 324602003702 homodimer interface [polypeptide binding]; other site 324602003703 catalytic site [active] 324602003704 acceptor binding site [chemical binding]; other site 324602003705 trehalose synthase; Region: treS_nterm; TIGR02456 324602003706 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 324602003707 active site 324602003708 catalytic site [active] 324602003709 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl19286 324602003710 glycogen branching enzyme; Provisional; Region: PRK12313 324602003711 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 324602003712 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 324602003713 active site 324602003714 catalytic site [active] 324602003715 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 324602003716 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 324602003717 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 324602003718 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 324602003719 catalytic site [active] 324602003720 active site 324602003721 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 324602003722 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 324602003723 active site 324602003724 catalytic site [active] 324602003725 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 324602003726 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 324602003727 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 324602003728 active site 324602003729 catalytic site [active] 324602003730 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 324602003731 adenylosuccinate lyase; Provisional; Region: PRK09285 324602003732 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 324602003733 tetramer interface [polypeptide binding]; other site 324602003734 active site 324602003735 Transcriptional regulators [Transcription]; Region: MarR; COG1846 324602003736 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 324602003737 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 324602003738 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 324602003739 HlyD family secretion protein; Region: HlyD_3; pfam13437 324602003740 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 324602003741 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 324602003742 FtsX-like permease family; Region: FtsX; pfam02687 324602003743 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324602003744 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324602003745 NAD(P) binding site [chemical binding]; other site 324602003746 active site 324602003747 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 324602003748 GAF domain; Region: GAF_2; pfam13185 324602003749 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 324602003750 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602003751 putative active site [active] 324602003752 heme pocket [chemical binding]; other site 324602003753 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602003754 dimer interface [polypeptide binding]; other site 324602003755 phosphorylation site [posttranslational modification] 324602003756 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602003757 ATP binding site [chemical binding]; other site 324602003758 Mg2+ binding site [ion binding]; other site 324602003759 G-X-G motif; other site 324602003760 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 324602003761 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324602003762 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602003763 homodimer interface [polypeptide binding]; other site 324602003764 catalytic residue [active] 324602003765 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 324602003766 Double zinc ribbon; Region: DZR; pfam12773 324602003767 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 324602003768 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 324602003769 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 324602003770 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 324602003771 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 324602003772 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 324602003773 Predicted transcriptional regulator [Transcription]; Region: COG2345 324602003774 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324602003775 putative DNA binding site [nucleotide binding]; other site 324602003776 putative Zn2+ binding site [ion binding]; other site 324602003777 Alkyl sulfatase dimerization; Region: Alkyl_sulf_dimr; pfam14863 324602003778 antiporter inner membrane protein; Provisional; Region: PRK11670 324602003779 Domain of unknown function DUF59; Region: DUF59; pfam01883 324602003780 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 324602003781 Walker A motif; other site 324602003782 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 324602003783 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324602003784 FeS/SAM binding site; other site 324602003785 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 324602003786 heat shock protein 90; Provisional; Region: PRK05218 324602003787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602003788 ATP binding site [chemical binding]; other site 324602003789 Mg2+ binding site [ion binding]; other site 324602003790 G-X-G motif; other site 324602003791 Hsp90 protein; Region: HSP90; pfam00183 324602003792 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324602003793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602003794 putative substrate translocation pore; other site 324602003795 Colicin V production protein; Region: Colicin_V; pfam02674 324602003796 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 324602003797 MutS domain III; Region: MutS_III; pfam05192 324602003798 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 324602003799 Walker A/P-loop; other site 324602003800 ATP binding site [chemical binding]; other site 324602003801 Q-loop/lid; other site 324602003802 ABC transporter signature motif; other site 324602003803 Walker B; other site 324602003804 D-loop; other site 324602003805 H-loop/switch region; other site 324602003806 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 324602003807 heterodimer interface [polypeptide binding]; other site 324602003808 homodimer interface [polypeptide binding]; other site 324602003809 Smr domain; Region: Smr; pfam01713 324602003810 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 324602003811 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 324602003812 putative dimer interface [polypeptide binding]; other site 324602003813 [2Fe-2S] cluster binding site [ion binding]; other site 324602003814 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 324602003815 dimer interface [polypeptide binding]; other site 324602003816 [2Fe-2S] cluster binding site [ion binding]; other site 324602003817 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 324602003818 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 324602003819 SLBB domain; Region: SLBB; pfam10531 324602003820 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 324602003821 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 324602003822 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 324602003823 catalytic loop [active] 324602003824 iron binding site [ion binding]; other site 324602003825 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 324602003826 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 324602003827 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 324602003828 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 324602003829 Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066 324602003830 nickel binding site [ion binding]; other site 324602003831 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 324602003832 Protein of unknown function (DUF4013); Region: DUF4013; pfam13197 324602003833 Protein of unknown function (DUF4013); Region: DUF4013; pfam13197 324602003834 competence damage-inducible protein A; Provisional; Region: PRK00549 324602003835 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 324602003836 putative MPT binding site; other site 324602003837 Competence-damaged protein; Region: CinA; cl00666 324602003838 YtxH-like protein; Region: YtxH; pfam12732 324602003839 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 324602003840 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 324602003841 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 324602003842 active site 324602003843 dimer interface [polypeptide binding]; other site 324602003844 motif 1; other site 324602003845 motif 2; other site 324602003846 motif 3; other site 324602003847 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 324602003848 anticodon binding site; other site 324602003849 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 324602003850 cobalamin synthase; Reviewed; Region: cobS; PRK00235 324602003851 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 324602003852 catalytic core [active] 324602003853 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 324602003854 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 324602003855 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 324602003856 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 324602003857 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 324602003858 catalytic residues [active] 324602003859 catalytic nucleophile [active] 324602003860 acetyl-lysine deacetylase; Provisional; Region: PRK04443 324602003861 M20 Peptidase acetylornithine deacetylase/acetyl-lysine deacetylase; Region: M20_ArgE_LysK; cd05653 324602003862 metal binding site [ion binding]; metal-binding site 324602003863 putative dimer interface [polypeptide binding]; other site 324602003864 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602003865 ATP binding site [chemical binding]; other site 324602003866 Mg2+ binding site [ion binding]; other site 324602003867 G-X-G motif; other site 324602003868 YcxB-like protein; Region: YcxB; pfam14317 324602003869 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 324602003870 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 324602003871 AAA domain; Region: AAA_12; pfam13087 324602003872 GAF domain; Region: GAF; pfam01590 324602003873 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324602003874 Histidine kinase; Region: HisKA_3; pfam07730 324602003875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602003876 ATP binding site [chemical binding]; other site 324602003877 Mg2+ binding site [ion binding]; other site 324602003878 G-X-G motif; other site 324602003879 Arsenite oxidase (Arsenite-Ox) oxidizes arsenite to the less toxic arsenate; it transfers the electrons obtained from the oxidation of arsenite towards the soluble periplasmic electron carriers cytochrome c and/or amicyanin. Arsenite oxidase is a...; Region: MopB_Arsenite-Ox; cd02756 324602003880 arsenite oxidase, large subunit; Region: arsenite_ox_L; TIGR02693 324602003881 [3Fe-4S] binding site [ion binding]; other site 324602003882 molybdopterin cofactor binding site [chemical binding]; other site 324602003883 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of Arsenite oxidase (Arsenite-Ox) and related proteins. Arsenite oxidase oxidizes arsenite to the less toxic arsenate; it transfers the electrons obtained from the oxidation of...; Region: MopB_CT_Arsenite-Ox; cd02779 324602003884 molybdopterin cofactor binding site; other site 324602003885 Small subunit of Arsenite oxidase (ArOX) family, Rieske domain; ArOX is a molybdenum/iron protein involved in the detoxification of arsenic, oxidizing it to arsenate. It consists of two subunits, a large subunit similar to members of the DMSO reductase...; Region: Rieske_ArOX_small; cd03476 324602003886 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 324602003887 [2Fe-2S] cluster binding site [ion binding]; other site 324602003888 subunit interaction site [polypeptide binding]; other site 324602003889 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324602003890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602003891 active site 324602003892 phosphorylation site [posttranslational modification] 324602003893 intermolecular recognition site; other site 324602003894 dimerization interface [polypeptide binding]; other site 324602003895 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 324602003896 dimerization interface [polypeptide binding]; other site 324602003897 DNA binding residues [nucleotide binding] 324602003898 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 324602003899 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 324602003900 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 324602003901 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 324602003902 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324602003903 motif II; other site 324602003904 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 324602003905 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 324602003906 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130 324602003907 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 324602003908 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 324602003909 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324602003910 extended (e) SDRs; Region: SDR_e; cd08946 324602003911 NAD(P) binding site [chemical binding]; other site 324602003912 active site 324602003913 substrate binding site [chemical binding]; other site 324602003914 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 324602003915 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 324602003916 substrate binding site; other site 324602003917 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324602003918 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 324602003919 NAD binding site [chemical binding]; other site 324602003920 putative substrate binding site 2 [chemical binding]; other site 324602003921 putative substrate binding site 1 [chemical binding]; other site 324602003922 active site 324602003923 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324602003924 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324602003925 NAD(P) binding site [chemical binding]; other site 324602003926 active site 324602003927 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 324602003928 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 324602003929 inhibitor-cofactor binding pocket; inhibition site 324602003930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602003931 catalytic residue [active] 324602003932 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 324602003933 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 324602003934 ligand binding site [chemical binding]; other site 324602003935 flexible hinge region; other site 324602003936 non-specific DNA interactions [nucleotide binding]; other site 324602003937 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 324602003938 DNA binding site [nucleotide binding] 324602003939 sequence specific DNA binding site [nucleotide binding]; other site 324602003940 putative cAMP binding site [chemical binding]; other site 324602003941 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 324602003942 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 324602003943 putative acyl-acceptor binding pocket; other site 324602003944 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324602003945 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324602003946 NAD(P) binding site [chemical binding]; other site 324602003947 active site 324602003948 Fic/DOC family; Region: Fic; cl00960 324602003949 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 324602003950 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 324602003951 dimer interface [polypeptide binding]; other site 324602003952 putative anticodon binding site; other site 324602003953 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 324602003954 motif 1; other site 324602003955 active site 324602003956 motif 2; other site 324602003957 motif 3; other site 324602003958 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 324602003959 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 324602003960 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 324602003961 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 324602003962 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 324602003963 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 324602003964 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 324602003965 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 324602003966 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 324602003967 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 324602003968 Metallopeptidase family M24; Region: Peptidase_M24; pfam00557 324602003969 active site 324602003970 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 324602003971 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 324602003972 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 324602003973 Sulfate transporter family; Region: Sulfate_transp; pfam00916 324602003974 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 324602003975 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 324602003976 active site residue [active] 324602003977 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 324602003978 active site 324602003979 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 324602003980 TRAM domain; Region: TRAM; pfam01938 324602003981 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602003982 S-adenosylmethionine binding site [chemical binding]; other site 324602003983 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 324602003984 Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154 324602003985 Rab subfamily motif 1 (RabSF1); other site 324602003986 G1 box; other site 324602003987 GTP/Mg2+ binding site [chemical binding]; other site 324602003988 Rab subfamily motif 2 (RabSF2); other site 324602003989 Switch I region; other site 324602003990 G2 box; other site 324602003991 effector interaction site; other site 324602003992 GDI interaction site; other site 324602003993 Rab family motif 1 (RabF1); other site 324602003994 GEF interaction site [polypeptide binding]; other site 324602003995 Rab family motif 2 (RabF2); other site 324602003996 G3 box; other site 324602003997 Switch II region; other site 324602003998 Rab family motif 3 (RabF3); other site 324602003999 Rab family motif 4 (RabF4); other site 324602004000 Rab family motif 5 (RabF5); other site 324602004001 Rab subfamily motif 3 (RabSF3); other site 324602004002 G4 box; other site 324602004003 G5 box; other site 324602004004 Rab subfamily motif 4 (RabSF4); other site 324602004005 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 324602004006 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 324602004007 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602004008 dimer interface [polypeptide binding]; other site 324602004009 phosphorylation site [posttranslational modification] 324602004010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602004011 ATP binding site [chemical binding]; other site 324602004012 Mg2+ binding site [ion binding]; other site 324602004013 G-X-G motif; other site 324602004014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602004015 active site 324602004016 phosphorylation site [posttranslational modification] 324602004017 intermolecular recognition site; other site 324602004018 dimerization interface [polypeptide binding]; other site 324602004019 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 324602004020 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 324602004021 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 324602004022 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 324602004023 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 324602004024 DNA gyrase subunit A; Validated; Region: PRK05560 324602004025 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 324602004026 CAP-like domain; other site 324602004027 active site 324602004028 primary dimer interface [polypeptide binding]; other site 324602004029 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 324602004030 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 324602004031 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 324602004032 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 324602004033 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 324602004034 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 324602004035 DNA methylase; Region: N6_N4_Mtase; pfam01555 324602004036 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 324602004037 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 324602004038 catalytic residues [active] 324602004039 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 324602004040 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602004041 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324602004042 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 324602004043 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324602004044 Coenzyme A binding pocket [chemical binding]; other site 324602004045 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 324602004046 GTPase RsgA; Reviewed; Region: PRK00098 324602004047 RNA binding site [nucleotide binding]; other site 324602004048 homodimer interface [polypeptide binding]; other site 324602004049 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 324602004050 GTPase/Zn-binding domain interface [polypeptide binding]; other site 324602004051 GTP/Mg2+ binding site [chemical binding]; other site 324602004052 G4 box; other site 324602004053 G5 box; other site 324602004054 G1 box; other site 324602004055 Switch I region; other site 324602004056 G2 box; other site 324602004057 G3 box; other site 324602004058 Switch II region; other site 324602004059 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 324602004060 tetramer interface [polypeptide binding]; other site 324602004061 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602004062 catalytic residue [active] 324602004063 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324602004064 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 324602004065 active site 324602004066 catalytic tetrad [active] 324602004067 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 324602004068 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 324602004069 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 324602004070 putative RNA binding site [nucleotide binding]; other site 324602004071 Methyltransferase domain; Region: Methyltransf_26; pfam13659 324602004072 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 324602004073 heterotetramer interface [polypeptide binding]; other site 324602004074 active site pocket [active] 324602004075 cleavage site 324602004076 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 324602004077 Protein of unknown function (DUF503); Region: DUF503; pfam04456 324602004078 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 324602004079 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602004080 Walker A motif; other site 324602004081 ATP binding site [chemical binding]; other site 324602004082 Walker B motif; other site 324602004083 arginine finger; other site 324602004084 Uncharacterized conserved protein containing a coiled-coil domain [Function unknown]; Region: COG5493 324602004085 Protein of unknown function (DUF1626); Region: DUF1626; pfam07788 324602004086 MAEBL; Provisional; Region: PTZ00121 324602004087 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 324602004088 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324602004089 catalytic residue [active] 324602004090 CHAT domain; Region: CHAT; cl19248 324602004091 Predicted membrane protein [Function unknown]; Region: COG2261 324602004092 Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Ade5; cd01416 324602004093 ATP binding site [chemical binding]; other site 324602004094 active site 324602004095 substrate binding site [chemical binding]; other site 324602004096 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 324602004097 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 324602004098 dimerization interface [polypeptide binding]; other site 324602004099 putative ATP binding site [chemical binding]; other site 324602004100 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 324602004101 ATP phosphoribosyltransferase; Region: HisG; cl15266 324602004102 HisG, C-terminal domain; Region: HisG_C; cl06867 324602004103 Creatinine amidohydrolase; Region: Creatininase; cl00618 324602004104 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 324602004105 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 324602004106 dimer interface [polypeptide binding]; other site 324602004107 motif 1; other site 324602004108 active site 324602004109 motif 2; other site 324602004110 motif 3; other site 324602004111 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 324602004112 anticodon binding site; other site 324602004113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602004114 active site 324602004115 phosphorylation site [posttranslational modification] 324602004116 intermolecular recognition site; other site 324602004117 dimerization interface [polypeptide binding]; other site 324602004118 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 324602004119 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602004120 dimer interface [polypeptide binding]; other site 324602004121 phosphorylation site [posttranslational modification] 324602004122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602004123 ATP binding site [chemical binding]; other site 324602004124 Mg2+ binding site [ion binding]; other site 324602004125 G-X-G motif; other site 324602004126 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 324602004127 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 324602004128 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 324602004129 metal ion-dependent adhesion site (MIDAS); other site 324602004130 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 324602004131 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 324602004132 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602004133 dimer interface [polypeptide binding]; other site 324602004134 putative PBP binding loops; other site 324602004135 ABC-ATPase subunit interface; other site 324602004136 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324602004137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602004138 dimer interface [polypeptide binding]; other site 324602004139 conserved gate region; other site 324602004140 putative PBP binding loops; other site 324602004141 ABC-ATPase subunit interface; other site 324602004142 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324602004143 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 324602004144 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 324602004145 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 324602004146 RNA/DNA hybrid binding site [nucleotide binding]; other site 324602004147 active site 324602004148 dihydrodipicolinate reductase; Provisional; Region: PRK00048 324602004149 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 324602004150 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 324602004151 DinB superfamily; Region: DinB_2; pfam12867 324602004152 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 324602004153 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 324602004154 ligand binding site [chemical binding]; other site 324602004155 flexible hinge region; other site 324602004156 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 324602004157 putative switch regulator; other site 324602004158 non-specific DNA interactions [nucleotide binding]; other site 324602004159 DNA binding site [nucleotide binding] 324602004160 sequence specific DNA binding site [nucleotide binding]; other site 324602004161 putative cAMP binding site [chemical binding]; other site 324602004162 Thermophilic metalloprotease (M29); Region: Peptidase_M29; cl19596 324602004163 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 324602004164 Collagenase; Region: DUF3656; pfam12392 324602004165 Quinolinate phosphoribosyl transferase, C-terminal domain; Region: QRPTase_C; cl19145 324602004166 Peptidase family U32; Region: Peptidase_U32; cl03113 324602004167 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 324602004168 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 324602004169 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 324602004170 Catalytic site [active] 324602004171 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 324602004172 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602004173 GTPase CgtA; Reviewed; Region: obgE; PRK12297 324602004174 GTP1/OBG; Region: GTP1_OBG; pfam01018 324602004175 Obg GTPase; Region: Obg; cd01898 324602004176 G1 box; other site 324602004177 GTP/Mg2+ binding site [chemical binding]; other site 324602004178 Switch I region; other site 324602004179 G2 box; other site 324602004180 G3 box; other site 324602004181 Switch II region; other site 324602004182 G4 box; other site 324602004183 G5 box; other site 324602004184 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 324602004185 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 324602004186 Putative lysophospholipase; Region: Hydrolase_4; cl19140 324602004187 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324602004188 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 324602004189 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 324602004190 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 324602004191 active site 324602004192 DNA binding site [nucleotide binding] 324602004193 Int/Topo IB signature motif; other site 324602004194 PAS fold; Region: PAS_3; pfam08447 324602004195 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602004196 putative active site [active] 324602004197 heme pocket [chemical binding]; other site 324602004198 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 324602004199 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324602004200 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 324602004201 NAD(P) binding site [chemical binding]; other site 324602004202 active site 324602004203 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 324602004204 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 324602004205 putative ADP-ribose binding site [chemical binding]; other site 324602004206 putative active site [active] 324602004207 PspC domain; Region: PspC; pfam04024 324602004208 Integral membrane protein DUF92; Region: DUF92; pfam01940 324602004209 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 324602004210 hydrophobic ligand binding site; other site 324602004211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602004212 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 324602004213 putative substrate translocation pore; other site 324602004214 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324602004215 Coenzyme A binding pocket [chemical binding]; other site 324602004216 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 324602004217 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 324602004218 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324602004219 FeS/SAM binding site; other site 324602004220 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 324602004221 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 324602004222 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 324602004223 VanW like protein; Region: VanW; pfam04294 324602004224 G5 domain; Region: G5; pfam07501 324602004225 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 324602004226 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324602004227 Sensor protein DegS; Region: DegS; pfam05384 324602004228 Histidine kinase; Region: HisKA_3; pfam07730 324602004229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602004230 ATP binding site [chemical binding]; other site 324602004231 Mg2+ binding site [ion binding]; other site 324602004232 G-X-G motif; other site 324602004233 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 324602004234 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324602004235 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324602004236 dimerization interface [polypeptide binding]; other site 324602004237 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 324602004238 Part of AAA domain; Region: AAA_19; pfam13245 324602004239 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 324602004240 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 324602004241 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 324602004242 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 324602004243 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 324602004244 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 324602004245 prolyl-tRNA synthetase; Provisional; Region: PRK08661 324602004246 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 324602004247 dimer interface [polypeptide binding]; other site 324602004248 motif 1; other site 324602004249 active site 324602004250 motif 2; other site 324602004251 motif 3; other site 324602004252 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 324602004253 anticodon binding site; other site 324602004254 zinc-binding site [ion binding]; other site 324602004255 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 324602004256 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 324602004257 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 324602004258 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 324602004259 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 324602004260 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 324602004261 Ca binding site [ion binding]; other site 324602004262 active site 324602004263 catalytic site [active] 324602004264 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 324602004265 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 324602004266 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 324602004267 putative active site [active] 324602004268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602004269 putative substrate translocation pore; other site 324602004270 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324602004271 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 324602004272 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 324602004273 putative ADP-binding pocket [chemical binding]; other site 324602004274 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 324602004275 Ligand binding site; other site 324602004276 Putative Catalytic site; other site 324602004277 DXD motif; other site 324602004278 DAK2 domain; Region: Dak2; cl03685 324602004279 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 324602004280 active pocket/dimerization site; other site 324602004281 active site 324602004282 phosphorylation site [posttranslational modification] 324602004283 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 324602004284 dimerization domain swap beta strand [polypeptide binding]; other site 324602004285 regulatory protein interface [polypeptide binding]; other site 324602004286 active site 324602004287 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 324602004288 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 324602004289 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 324602004290 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 324602004291 Cupin domain; Region: Cupin_2; pfam07883 324602004292 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324602004293 dimerization interface [polypeptide binding]; other site 324602004294 putative DNA binding site [nucleotide binding]; other site 324602004295 putative Zn2+ binding site [ion binding]; other site 324602004296 Low molecular weight phosphatase family; Region: LMWPc; cd00115 324602004297 active site 324602004298 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 324602004299 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 324602004300 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 324602004301 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 324602004302 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 324602004303 dimerization domain swap beta strand [polypeptide binding]; other site 324602004304 regulatory protein interface [polypeptide binding]; other site 324602004305 active site 324602004306 regulatory phosphorylation site [posttranslational modification]; other site 324602004307 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 324602004308 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130 324602004309 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 324602004310 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 324602004311 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 324602004312 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 324602004313 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 324602004314 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 324602004315 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 324602004316 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 324602004317 Glucitol operon activator protein (GutM); Region: GutM; cl01890 324602004318 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 324602004319 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 324602004320 E3 interaction surface; other site 324602004321 lipoyl attachment site [posttranslational modification]; other site 324602004322 e3 binding domain; Region: E3_binding; pfam02817 324602004323 e3 binding domain; Region: E3_binding; pfam02817 324602004324 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 324602004325 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 324602004326 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 324602004327 alpha subunit interface [polypeptide binding]; other site 324602004328 TPP binding site [chemical binding]; other site 324602004329 heterodimer interface [polypeptide binding]; other site 324602004330 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 324602004331 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 324602004332 tetramer interface [polypeptide binding]; other site 324602004333 TPP-binding site [chemical binding]; other site 324602004334 heterodimer interface [polypeptide binding]; other site 324602004335 phosphorylation loop region [posttranslational modification] 324602004336 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 324602004337 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 324602004338 DNA binding residues [nucleotide binding] 324602004339 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 324602004340 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 324602004341 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 324602004342 Chlor_Arch_YYY domain; Region: Chlor_Arch_YYY; TIGR03662 324602004343 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 324602004344 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 324602004345 Chlor_Arch_YYY domain; Region: Chlor_Arch_YYY; TIGR03662 324602004346 Chlor_Arch_YYY domain; Region: Chlor_Arch_YYY; TIGR03662 324602004347 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602004348 binding surface 324602004349 TPR motif; other site 324602004350 TPR repeat; Region: TPR_11; pfam13414 324602004351 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602004352 TPR motif; other site 324602004353 binding surface 324602004354 TPR repeat; Region: TPR_11; pfam13414 324602004355 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 324602004356 dimer interface [polypeptide binding]; other site 324602004357 [2Fe-2S] cluster binding site [ion binding]; other site 324602004358 cysteine synthase; Region: PLN02565 324602004359 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 324602004360 dimer interface [polypeptide binding]; other site 324602004361 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602004362 catalytic residue [active] 324602004363 Uncharacterized conserved protein [Function unknown]; Region: COG3379 324602004364 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 324602004365 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 324602004366 Sulfatase; Region: Sulfatase; pfam00884 324602004367 enoyl-CoA hydratase; Validated; Region: PRK08139 324602004368 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 324602004369 substrate binding site [chemical binding]; other site 324602004370 oxyanion hole (OAH) forming residues; other site 324602004371 trimer interface [polypeptide binding]; other site 324602004372 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 324602004373 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 324602004374 N-terminal, non-catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_N_like; cd09013 324602004375 tetramer interface [polypeptide binding]; other site 324602004376 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 324602004377 C-terminal, catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_C_like; cd09014 324602004378 tetramer interface [polypeptide binding]; other site 324602004379 active site 324602004380 metal binding site [ion binding]; metal-binding site 324602004381 Transcriptional regulator [Transcription]; Region: IclR; COG1414 324602004382 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 324602004383 Bacterial transcriptional regulator; Region: IclR; pfam01614 324602004384 acetaldehyde dehydrogenase; Validated; Region: PRK08300 324602004385 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 324602004386 Prokaryotic acetaldehyde dehydrogenase, dimerization; Region: AcetDehyd-dimer; pfam09290 324602004387 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 324602004388 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 324602004389 active site 324602004390 catalytic residues [active] 324602004391 metal binding site [ion binding]; metal-binding site 324602004392 DmpG-like communication domain; Region: DmpG_comm; pfam07836 324602004393 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 324602004394 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 324602004395 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 324602004396 Putative lysophospholipase; Region: Hydrolase_4; cl19140 324602004397 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 324602004398 dimer interface [polypeptide binding]; other site 324602004399 hexamer interface [polypeptide binding]; other site 324602004400 active site 2 [active] 324602004401 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 324602004402 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 324602004403 NAD binding site [chemical binding]; other site 324602004404 catalytic residues [active] 324602004405 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 324602004406 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 324602004407 recombinase A; Provisional; Region: recA; PRK09354 324602004408 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 324602004409 hexamer interface [polypeptide binding]; other site 324602004410 Walker A motif; other site 324602004411 ATP binding site [chemical binding]; other site 324602004412 Walker B motif; other site 324602004413 Domain of unknown function (DUF427); Region: DUF427; pfam04248 324602004414 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 324602004415 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 324602004416 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 324602004417 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 324602004418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602004419 dimer interface [polypeptide binding]; other site 324602004420 conserved gate region; other site 324602004421 putative PBP binding loops; other site 324602004422 ABC-ATPase subunit interface; other site 324602004423 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 324602004424 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 324602004425 Walker A/P-loop; other site 324602004426 ATP binding site [chemical binding]; other site 324602004427 Q-loop/lid; other site 324602004428 ABC transporter signature motif; other site 324602004429 Walker B; other site 324602004430 D-loop; other site 324602004431 H-loop/switch region; other site 324602004432 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 324602004433 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 324602004434 Walker A/P-loop; other site 324602004435 ATP binding site [chemical binding]; other site 324602004436 Q-loop/lid; other site 324602004437 ABC transporter signature motif; other site 324602004438 Walker B; other site 324602004439 D-loop; other site 324602004440 H-loop/switch region; other site 324602004441 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 324602004442 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 324602004443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602004444 dimer interface [polypeptide binding]; other site 324602004445 conserved gate region; other site 324602004446 putative PBP binding loops; other site 324602004447 ABC-ATPase subunit interface; other site 324602004448 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 324602004449 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 324602004450 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602004451 Walker A motif; other site 324602004452 ATP binding site [chemical binding]; other site 324602004453 Walker B motif; other site 324602004454 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 324602004455 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 324602004456 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 324602004457 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 324602004458 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602004459 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324602004460 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 324602004461 CARDB; Region: CARDB; pfam07705 324602004462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602004463 S-adenosylmethionine binding site [chemical binding]; other site 324602004464 NAD synthetase; Reviewed; Region: nadE; PRK02628 324602004465 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 324602004466 multimer interface [polypeptide binding]; other site 324602004467 active site 324602004468 catalytic triad [active] 324602004469 protein interface 1 [polypeptide binding]; other site 324602004470 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 324602004471 homodimer interface [polypeptide binding]; other site 324602004472 NAD binding pocket [chemical binding]; other site 324602004473 ATP binding pocket [chemical binding]; other site 324602004474 Mg binding site [ion binding]; other site 324602004475 active-site loop [active] 324602004476 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 324602004477 tetramerization interface [polypeptide binding]; other site 324602004478 NAD(P) binding site [chemical binding]; other site 324602004479 catalytic residues [active] 324602004480 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 324602004481 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 324602004482 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 324602004483 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 324602004484 ATP-grasp domain; Region: ATP-grasp_4; cl17255 324602004485 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 324602004486 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 324602004487 carboxyltransferase (CT) interaction site; other site 324602004488 biotinylation site [posttranslational modification]; other site 324602004489 BtpA family; Region: BtpA; cl00440 324602004490 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 324602004491 substrate binding site [chemical binding]; other site 324602004492 ATP binding site [chemical binding]; other site 324602004493 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602004494 active site 324602004495 phosphorylation site [posttranslational modification] 324602004496 intermolecular recognition site; other site 324602004497 dimerization interface [polypeptide binding]; other site 324602004498 GAF domain; Region: GAF; pfam01590 324602004499 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 324602004500 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602004501 putative active site [active] 324602004502 heme pocket [chemical binding]; other site 324602004503 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602004504 dimer interface [polypeptide binding]; other site 324602004505 phosphorylation site [posttranslational modification] 324602004506 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602004507 ATP binding site [chemical binding]; other site 324602004508 Mg2+ binding site [ion binding]; other site 324602004509 G-X-G motif; other site 324602004510 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602004511 active site 324602004512 phosphorylation site [posttranslational modification] 324602004513 intermolecular recognition site; other site 324602004514 dimerization interface [polypeptide binding]; other site 324602004515 Initiation factor 2 subunit family; Region: IF-2B; cl00348 324602004516 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602004517 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 324602004518 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 324602004519 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 324602004520 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324602004521 dimerization interface [polypeptide binding]; other site 324602004522 PAS domain; Region: PAS; smart00091 324602004523 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602004524 dimer interface [polypeptide binding]; other site 324602004525 phosphorylation site [posttranslational modification] 324602004526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602004527 ATP binding site [chemical binding]; other site 324602004528 Mg2+ binding site [ion binding]; other site 324602004529 G-X-G motif; other site 324602004530 Calx-beta domain; Region: Calx-beta; pfam03160 324602004531 Calx-beta domain; Region: Calx-beta; cl02522 324602004532 Calx-beta domain; Region: Calx-beta; cl02522 324602004533 Calx-beta domain; Region: Calx-beta; cl02522 324602004534 Calx-beta domain; Region: Calx-beta; cl02522 324602004535 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 324602004536 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 324602004537 active site 324602004538 ribulose/triose binding site [chemical binding]; other site 324602004539 phosphate binding site [ion binding]; other site 324602004540 substrate (anthranilate) binding pocket [chemical binding]; other site 324602004541 product (indole) binding pocket [chemical binding]; other site 324602004542 Double zinc ribbon; Region: DZR; pfam12773 324602004543 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 324602004544 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 324602004545 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 324602004546 30S subunit binding site; other site 324602004547 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 324602004548 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 324602004549 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 324602004550 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 324602004551 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324602004552 Histidine kinase; Region: HisKA_3; pfam07730 324602004553 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602004554 ATP binding site [chemical binding]; other site 324602004555 Mg2+ binding site [ion binding]; other site 324602004556 G-X-G motif; other site 324602004557 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324602004558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602004559 active site 324602004560 phosphorylation site [posttranslational modification] 324602004561 intermolecular recognition site; other site 324602004562 dimerization interface [polypeptide binding]; other site 324602004563 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324602004564 DNA binding residues [nucleotide binding] 324602004565 dimerization interface [polypeptide binding]; other site 324602004566 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 324602004567 cyclase homology domain; Region: CHD; cd07302 324602004568 nucleotidyl binding site; other site 324602004569 metal binding site [ion binding]; metal-binding site 324602004570 dimer interface [polypeptide binding]; other site 324602004571 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 324602004572 cyclase homology domain; Region: CHD; cd07302 324602004573 nucleotidyl binding site; other site 324602004574 metal binding site [ion binding]; metal-binding site 324602004575 dimer interface [polypeptide binding]; other site 324602004576 AAA ATPase domain; Region: AAA_16; pfam13191 324602004577 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 324602004578 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602004579 binding surface 324602004580 TPR motif; other site 324602004581 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602004582 binding surface 324602004583 TPR motif; other site 324602004584 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324602004585 Quinolinate synthetase A protein; Region: NadA; pfam02445 324602004586 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 324602004587 L-aspartate oxidase; Provisional; Region: PRK06175 324602004588 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 324602004589 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 324602004590 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 324602004591 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 324602004592 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 324602004593 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 324602004594 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 324602004595 DNA binding site [nucleotide binding] 324602004596 active site 324602004597 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 324602004598 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 324602004599 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 324602004600 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 324602004601 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 324602004602 active site 324602004603 HIGH motif; other site 324602004604 dimer interface [polypeptide binding]; other site 324602004605 KMSKS motif; other site 324602004606 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 324602004607 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602004608 catalytic residue [active] 324602004609 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 324602004610 phytoene desaturase; Region: crtI_fam; TIGR02734 324602004611 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 324602004612 CheW-like domain; Region: CheW; pfam01584 324602004613 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 324602004614 MgtC family; Region: MgtC; pfam02308 324602004615 Predicted membrane protein [Function unknown]; Region: COG3174 324602004616 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 324602004617 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 324602004618 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14604 324602004619 RuvA N terminal domain; Region: RuvA_N; pfam01330 324602004620 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 324602004621 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324602004622 active site 324602004623 Bifunctional nuclease; Region: DNase-RNase; pfam02577 324602004624 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 324602004625 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324602004626 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 324602004627 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324602004628 Bacterial SH3 domain; Region: SH3_4; pfam06347 324602004629 Peptidase family M23; Region: Peptidase_M23; pfam01551 324602004630 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 324602004631 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 324602004632 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 324602004633 P-loop; other site 324602004634 Magnesium ion binding site [ion binding]; other site 324602004635 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 324602004636 ParB-like nuclease domain; Region: ParBc; pfam02195 324602004637 Ribokinase-like subgroup D. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_D; cd01937 324602004638 substrate binding site [chemical binding]; other site 324602004639 ATP binding site [chemical binding]; other site 324602004640 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 324602004641 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 324602004642 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 324602004643 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 324602004644 putative dimer interface [polypeptide binding]; other site 324602004645 putative anticodon binding site; other site 324602004646 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 324602004647 homodimer interface [polypeptide binding]; other site 324602004648 motif 1; other site 324602004649 motif 2; other site 324602004650 active site 324602004651 motif 3; other site 324602004652 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 324602004653 M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896 324602004654 putative metal binding site [ion binding]; other site 324602004655 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 324602004656 active site 324602004657 catalytic site [active] 324602004658 Methyltransferase domain; Region: Methyltransf_31; pfam13847 324602004659 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602004660 S-adenosylmethionine binding site [chemical binding]; other site 324602004661 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 324602004662 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 324602004663 homodimer interface [polypeptide binding]; other site 324602004664 substrate-cofactor binding pocket; other site 324602004665 catalytic residue [active] 324602004666 multidrug resistance protein MdtH; Provisional; Region: PRK11646 324602004667 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602004668 putative substrate translocation pore; other site 324602004669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602004670 S-adenosylmethionine binding site [chemical binding]; other site 324602004671 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 324602004672 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 324602004673 Zn binding site [ion binding]; other site 324602004674 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 324602004675 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 324602004676 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324602004677 Zn2+ binding site [ion binding]; other site 324602004678 Mg2+ binding site [ion binding]; other site 324602004679 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 324602004680 synthetase active site [active] 324602004681 NTP binding site [chemical binding]; other site 324602004682 metal binding site [ion binding]; metal-binding site 324602004683 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 324602004684 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 324602004685 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 324602004686 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 324602004687 minor groove reading motif; other site 324602004688 helix-hairpin-helix signature motif; other site 324602004689 substrate binding pocket [chemical binding]; other site 324602004690 active site 324602004691 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 324602004692 AzlC protein; Region: AzlC; cl00570 324602004693 GAF domain; Region: GAF_2; pfam13185 324602004694 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602004695 dimer interface [polypeptide binding]; other site 324602004696 phosphorylation site [posttranslational modification] 324602004697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602004698 ATP binding site [chemical binding]; other site 324602004699 Mg2+ binding site [ion binding]; other site 324602004700 G-X-G motif; other site 324602004701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602004702 active site 324602004703 phosphorylation site [posttranslational modification] 324602004704 intermolecular recognition site; other site 324602004705 dimerization interface [polypeptide binding]; other site 324602004706 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 324602004707 Aspartase; Region: Aspartase; cd01357 324602004708 active sites [active] 324602004709 tetramer interface [polypeptide binding]; other site 324602004710 Putative lysophospholipase; Region: Hydrolase_4; cl19140 324602004711 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 324602004712 Cupredoxin superfamily; Region: Cupredoxin; cl19115 324602004713 G8 domain; Region: G8; pfam10162 324602004714 Right handed beta helix region; Region: Beta_helix; pfam13229 324602004715 glutamine synthetase, type I; Region: GlnA; TIGR00653 324602004716 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 324602004717 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 324602004718 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 324602004719 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324602004720 catalytic residue [active] 324602004721 CRISPR/Cas system-associated protein Csx15; Region: Csx15_I-U; cd09766 324602004722 META domain; Region: META; pfam03724 324602004723 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 324602004724 active site 324602004725 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 324602004726 FAD binding site [chemical binding]; other site 324602004727 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 324602004728 homodimer interface [polypeptide binding]; other site 324602004729 substrate-cofactor binding pocket; other site 324602004730 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602004731 catalytic residue [active] 324602004732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602004733 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 324602004734 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324602004735 Coenzyme A binding pocket [chemical binding]; other site 324602004736 beta-ketothiolase; Provisional; Region: PRK09051 324602004737 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 324602004738 dimer interface [polypeptide binding]; other site 324602004739 active site 324602004740 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 324602004741 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 324602004742 NAD(P) binding site [chemical binding]; other site 324602004743 homotetramer interface [polypeptide binding]; other site 324602004744 homodimer interface [polypeptide binding]; other site 324602004745 active site 324602004746 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 324602004747 AAA domain; Region: AAA_22; pfam13401 324602004748 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 324602004749 Bacterial transcriptional activator domain; Region: BTAD; smart01043 324602004750 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 324602004751 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 324602004752 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 324602004753 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 324602004754 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 324602004755 active site 324602004756 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602004757 active site 324602004758 phosphorylation site [posttranslational modification] 324602004759 intermolecular recognition site; other site 324602004760 dimerization interface [polypeptide binding]; other site 324602004761 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602004762 ATP binding site [chemical binding]; other site 324602004763 Mg2+ binding site [ion binding]; other site 324602004764 G-X-G motif; other site 324602004765 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 324602004766 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 324602004767 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 324602004768 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 324602004769 anti sigma factor interaction site; other site 324602004770 regulatory phosphorylation site [posttranslational modification]; other site 324602004771 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 324602004772 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 324602004773 active site 324602004774 Substrate binding site; other site 324602004775 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 324602004776 putative trimer interface [polypeptide binding]; other site 324602004777 putative CoA binding site [chemical binding]; other site 324602004778 Bacterial sugar transferase; Region: Bac_transf; cl00939 324602004779 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 324602004780 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 324602004781 anti sigma factor interaction site; other site 324602004782 regulatory phosphorylation site [posttranslational modification]; other site 324602004783 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 324602004784 anti sigma factor interaction site; other site 324602004785 regulatory phosphorylation site [posttranslational modification]; other site 324602004786 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 324602004787 Bacterial sugar transferase; Region: Bac_transf; pfam02397 324602004788 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 324602004789 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 324602004790 trimer interface [polypeptide binding]; other site 324602004791 active site 324602004792 substrate binding site [chemical binding]; other site 324602004793 CoA binding site [chemical binding]; other site 324602004794 Chain length determinant protein; Region: Wzz; pfam02706 324602004795 ZW10 interactor; Region: Zwint; pfam15556 324602004796 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 324602004797 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 324602004798 O-Antigen ligase; Region: Wzy_C; pfam04932 324602004799 DDE superfamily endonuclease; Region: DDE_5; cl17874 324602004800 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 324602004801 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 324602004802 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 324602004803 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 324602004804 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 324602004805 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324602004806 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324602004807 DNA binding residues [nucleotide binding] 324602004808 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 324602004809 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 324602004810 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 324602004811 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 324602004812 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 324602004813 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324602004814 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324602004815 DNA binding residues [nucleotide binding] 324602004816 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 324602004817 Chain length determinant protein; Region: Wzz; pfam02706 324602004818 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 324602004819 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 324602004820 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 324602004821 metal binding triad [ion binding]; metal-binding site 324602004822 HEPN domain; Region: HEPN; pfam05168 324602004823 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 324602004824 CoA binding domain; Region: CoA_binding; cl17356 324602004825 Bacterial sugar transferase; Region: Bac_transf; pfam02397 324602004826 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 324602004827 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 324602004828 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602004829 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324602004830 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602004831 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844 324602004832 putative ADP-binding pocket [chemical binding]; other site 324602004833 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 324602004834 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 324602004835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602004836 S-adenosylmethionine binding site [chemical binding]; other site 324602004837 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 324602004838 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 324602004839 Methyltransferase domain; Region: Methyltransf_31; pfam13847 324602004840 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602004841 S-adenosylmethionine binding site [chemical binding]; other site 324602004842 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602004843 TPR motif; other site 324602004844 TPR repeat; Region: TPR_11; pfam13414 324602004845 binding surface 324602004846 TPR repeat; Region: TPR_11; pfam13414 324602004847 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602004848 binding surface 324602004849 TPR motif; other site 324602004850 Cytochrome P450; Region: p450; pfam00067 324602004851 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 324602004852 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 324602004853 active site 324602004854 substrate binding site [chemical binding]; other site 324602004855 metal binding site [ion binding]; metal-binding site 324602004856 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 324602004857 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 324602004858 metal binding site [ion binding]; metal-binding site 324602004859 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cl00425 324602004860 phosphate binding site [ion binding]; other site 324602004861 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324602004862 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 324602004863 catalytic site [active] 324602004864 Bacterial PH domain; Region: bPH_4; cl19751 324602004865 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602004866 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 324602004867 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 324602004868 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 324602004869 active site 324602004870 Ap6A binding site [chemical binding]; other site 324602004871 nudix motif; other site 324602004872 metal binding site [ion binding]; metal-binding site 324602004873 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 324602004874 trigger factor; Region: tig; TIGR00115 324602004875 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 324602004876 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 324602004877 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 324602004878 oligomer interface [polypeptide binding]; other site 324602004879 active site residues [active] 324602004880 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602004881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602004882 active site 324602004883 phosphorylation site [posttranslational modification] 324602004884 intermolecular recognition site; other site 324602004885 dimerization interface [polypeptide binding]; other site 324602004886 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324602004887 DNA binding site [nucleotide binding] 324602004888 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324602004889 active site 324602004890 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 324602004891 Mg++ binding site [ion binding]; other site 324602004892 putative catalytic motif [active] 324602004893 substrate binding site [chemical binding]; other site 324602004894 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 324602004895 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 324602004896 ligand binding site [chemical binding]; other site 324602004897 flexible hinge region; other site 324602004898 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 324602004899 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 324602004900 ligand binding site [chemical binding]; other site 324602004901 flexible hinge region; other site 324602004902 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 324602004903 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 324602004904 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 324602004905 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 324602004906 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 324602004907 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 324602004908 gamma-glutamyl kinase; Provisional; Region: PRK05429 324602004909 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 324602004910 nucleotide binding site [chemical binding]; other site 324602004911 homotetrameric interface [polypeptide binding]; other site 324602004912 putative phosphate binding site [ion binding]; other site 324602004913 putative allosteric binding site; other site 324602004914 PUA domain; Region: PUA; pfam01472 324602004915 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 324602004916 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 324602004917 active site 324602004918 HIGH motif; other site 324602004919 KMSKS motif; other site 324602004920 maltodextrin glucosidase; Provisional; Region: PRK10785 324602004921 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 324602004922 homodimer interface [polypeptide binding]; other site 324602004923 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 324602004924 active site 324602004925 homodimer interface [polypeptide binding]; other site 324602004926 catalytic site [active] 324602004927 ferredoxin-NADP+ reductase; Region: PLN02852 324602004928 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 324602004929 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602004930 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324602004931 putative acyltransferase; Provisional; Region: PRK05790 324602004932 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 324602004933 dimer interface [polypeptide binding]; other site 324602004934 active site 324602004935 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 324602004936 EamA-like transporter family; Region: EamA; pfam00892 324602004937 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 324602004938 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 324602004939 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 324602004940 Proteins of 100 residues with WXG; Region: WXG100; cl02005 324602004941 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 324602004942 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 324602004943 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324602004944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602004945 Putative zinc-finger; Region: zf-HC2; pfam13490 324602004946 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 324602004947 Transcriptional regulator [Transcription]; Region: LytR; COG1316 324602004948 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 324602004949 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 324602004950 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 324602004951 Ferredoxin [Energy production and conversion]; Region: COG1146 324602004952 4Fe-4S binding domain; Region: Fer4; pfam00037 324602004953 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 324602004954 Domain of unknown function (DUF814); Region: DUF814; pfam05670 324602004955 Guanylate kinase; Region: Guanylate_kin; pfam00625 324602004956 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 324602004957 catalytic site [active] 324602004958 G-X2-G-X-G-K; other site 324602004959 Yqey-like protein; Region: YqeY; cl17540 324602004960 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 324602004961 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 324602004962 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 324602004963 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324602004964 Zn2+ binding site [ion binding]; other site 324602004965 Mg2+ binding site [ion binding]; other site 324602004966 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 324602004967 PAS domain S-box; Region: sensory_box; TIGR00229 324602004968 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602004969 putative active site [active] 324602004970 heme pocket [chemical binding]; other site 324602004971 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602004972 PAS fold; Region: PAS_3; pfam08447 324602004973 putative active site [active] 324602004974 heme pocket [chemical binding]; other site 324602004975 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 324602004976 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 324602004977 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 324602004978 metal binding site [ion binding]; metal-binding site 324602004979 dimer interface [polypeptide binding]; other site 324602004980 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 324602004981 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 324602004982 putative active site [active] 324602004983 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 324602004984 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 324602004985 MoxR-like ATPases [General function prediction only]; Region: COG0714 324602004986 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602004987 Walker A motif; other site 324602004988 ATP binding site [chemical binding]; other site 324602004989 Walker B motif; other site 324602004990 arginine finger; other site 324602004991 enoyl-CoA hydratase; Provisional; Region: PRK05995 324602004992 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 324602004993 substrate binding site [chemical binding]; other site 324602004994 oxyanion hole (OAH) forming residues; other site 324602004995 trimer interface [polypeptide binding]; other site 324602004996 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 324602004997 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324602004998 Coenzyme A binding pocket [chemical binding]; other site 324602004999 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 324602005000 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 324602005001 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 324602005002 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 324602005003 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 324602005004 ligand binding site [chemical binding]; other site 324602005005 flexible hinge region; other site 324602005006 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 324602005007 putative switch regulator; other site 324602005008 non-specific DNA interactions [nucleotide binding]; other site 324602005009 DNA binding site [nucleotide binding] 324602005010 sequence specific DNA binding site [nucleotide binding]; other site 324602005011 putative cAMP binding site [chemical binding]; other site 324602005012 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 324602005013 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 324602005014 Cupredoxin domain 1 of Copper-containing nitrite reductase; Region: CuRO_1_CuNIR; cd11020 324602005015 Type 1 (T1) Cu binding site [ion binding]; other site 324602005016 trimer interface [polypeptide binding]; other site 324602005017 Type II Cu binding site [ion binding]; other site 324602005018 Cupredoxin domain 2 of Copper-containing nitrite reductase; Region: CuRO_2_CuNIR; cd04208 324602005019 trimer interface [polypeptide binding]; other site 324602005020 Cu binding site [ion binding]; other site 324602005021 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 324602005022 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 324602005023 Ligand binding site; other site 324602005024 Putative Catalytic site; other site 324602005025 DXD motif; other site 324602005026 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 324602005027 Protein of unknown function DUF86; Region: DUF86; pfam01934 324602005028 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 324602005029 active site 324602005030 NTP binding site [chemical binding]; other site 324602005031 metal binding triad [ion binding]; metal-binding site 324602005032 antibiotic binding site [chemical binding]; other site 324602005033 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 324602005034 YbbR-like protein; Region: YbbR; pfam07949 324602005035 Uncharacterized conserved protein [Function unknown]; Region: COG1624 324602005036 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 324602005037 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602005038 binding surface 324602005039 TPR motif; other site 324602005040 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 324602005041 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602005042 binding surface 324602005043 TPR motif; other site 324602005044 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602005045 binding surface 324602005046 TPR motif; other site 324602005047 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602005048 binding surface 324602005049 TPR motif; other site 324602005050 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602005051 TPR motif; other site 324602005052 binding surface 324602005053 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602005054 binding surface 324602005055 TPR motif; other site 324602005056 ornithine carbamoyltransferase; Provisional; Region: PRK00779 324602005057 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 324602005058 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 324602005059 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602005060 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 324602005061 Walker A motif; other site 324602005062 ATP binding site [chemical binding]; other site 324602005063 Walker B motif; other site 324602005064 arginine finger; other site 324602005065 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 324602005066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602005067 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324602005068 putative substrate translocation pore; other site 324602005069 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 324602005070 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 324602005071 dimer interface [polypeptide binding]; other site 324602005072 ssDNA binding site [nucleotide binding]; other site 324602005073 tetramer (dimer of dimers) interface [polypeptide binding]; other site 324602005074 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 324602005075 GAF domain; Region: GAF; pfam01590 324602005076 GAF domain; Region: GAF_3; pfam13492 324602005077 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324602005078 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602005079 dimer interface [polypeptide binding]; other site 324602005080 phosphorylation site [posttranslational modification] 324602005081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602005082 ATP binding site [chemical binding]; other site 324602005083 Mg2+ binding site [ion binding]; other site 324602005084 G-X-G motif; other site 324602005085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602005086 active site 324602005087 phosphorylation site [posttranslational modification] 324602005088 intermolecular recognition site; other site 324602005089 dimerization interface [polypeptide binding]; other site 324602005090 Bacterial SH3 domain; Region: SH3_3; pfam08239 324602005091 Bacterial SH3 domain; Region: SH3_3; pfam08239 324602005092 Bacterial SH3 domain; Region: SH3_3; pfam08239 324602005093 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 324602005094 NlpC/P60 family; Region: NLPC_P60; pfam00877 324602005095 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 324602005096 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324602005097 Walker A/P-loop; other site 324602005098 ATP binding site [chemical binding]; other site 324602005099 Q-loop/lid; other site 324602005100 ABC transporter signature motif; other site 324602005101 Walker B; other site 324602005102 D-loop; other site 324602005103 H-loop/switch region; other site 324602005104 Acyltransferase family; Region: Acyl_transf_3; cl19154 324602005105 Acyltransferase family; Region: Acyl_transf_3; cl19154 324602005106 Integral membrane protein DUF95; Region: DUF95; pfam01944 324602005107 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 324602005108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602005109 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324602005110 putative substrate translocation pore; other site 324602005111 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324602005112 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602005113 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324602005114 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 324602005115 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 324602005116 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 324602005117 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 324602005118 active site 324602005119 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 324602005120 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 324602005121 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 324602005122 Peptidase M16C associated; Region: M16C_assoc; pfam08367 324602005123 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951 324602005124 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 324602005125 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 324602005126 active site 324602005127 tetramer interface [polypeptide binding]; other site 324602005128 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324602005129 active site 324602005130 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 324602005131 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 324602005132 Subtilase family; Region: Peptidase_S8; pfam00082 324602005133 active site 324602005134 catalytic triad [active] 324602005135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602005136 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324602005137 putative substrate translocation pore; other site 324602005138 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 324602005139 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 324602005140 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 324602005141 phosphopeptide binding site; other site 324602005142 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 324602005143 FOG: CBS domain [General function prediction only]; Region: COG0517 324602005144 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 324602005145 FOG: CBS domain [General function prediction only]; Region: COG0517 324602005146 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 324602005147 FOG: CBS domain [General function prediction only]; Region: COG0517 324602005148 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 324602005149 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324602005150 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324602005151 NAD(P) binding site [chemical binding]; other site 324602005152 active site 324602005153 PHP domain; Region: PHP; pfam02811 324602005154 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 324602005155 active site 324602005156 Divergent AAA domain; Region: AAA_4; pfam04326 324602005157 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324602005158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602005159 active site 324602005160 phosphorylation site [posttranslational modification] 324602005161 intermolecular recognition site; other site 324602005162 dimerization interface [polypeptide binding]; other site 324602005163 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324602005164 DNA binding residues [nucleotide binding] 324602005165 dimerization interface [polypeptide binding]; other site 324602005166 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 324602005167 Zn binding site [ion binding]; other site 324602005168 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 324602005169 Zn binding site [ion binding]; other site 324602005170 Peptidase family M48; Region: Peptidase_M48; cl12018 324602005171 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 324602005172 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 324602005173 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 324602005174 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 324602005175 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 324602005176 Malic enzyme, N-terminal domain; Region: malic; pfam00390 324602005177 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 324602005178 putative NAD(P) binding site [chemical binding]; other site 324602005179 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 324602005180 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 324602005181 putative catalytic cysteine [active] 324602005182 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 324602005183 catalytic triad [active] 324602005184 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 324602005185 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 324602005186 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602005187 S-adenosylmethionine binding site [chemical binding]; other site 324602005188 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 324602005189 PGAP1-like protein; Region: PGAP1; pfam07819 324602005190 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324602005191 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 324602005192 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 324602005193 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 324602005194 active site 324602005195 catalytic site [active] 324602005196 substrate binding site [chemical binding]; other site 324602005197 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 324602005198 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 324602005199 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324602005200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602005201 active site 324602005202 phosphorylation site [posttranslational modification] 324602005203 intermolecular recognition site; other site 324602005204 dimerization interface [polypeptide binding]; other site 324602005205 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324602005206 DNA binding residues [nucleotide binding] 324602005207 dimerization interface [polypeptide binding]; other site 324602005208 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 324602005209 active site 324602005210 dimer interface [polypeptide binding]; other site 324602005211 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 324602005212 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 324602005213 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 324602005214 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 324602005215 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 324602005216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602005217 dimer interface [polypeptide binding]; other site 324602005218 conserved gate region; other site 324602005219 putative PBP binding loops; other site 324602005220 ABC-ATPase subunit interface; other site 324602005221 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 324602005222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602005223 dimer interface [polypeptide binding]; other site 324602005224 conserved gate region; other site 324602005225 putative PBP binding loops; other site 324602005226 ABC-ATPase subunit interface; other site 324602005227 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 324602005228 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 324602005229 Walker A/P-loop; other site 324602005230 ATP binding site [chemical binding]; other site 324602005231 Q-loop/lid; other site 324602005232 ABC transporter signature motif; other site 324602005233 Walker B; other site 324602005234 D-loop; other site 324602005235 H-loop/switch region; other site 324602005236 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 324602005237 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 324602005238 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 324602005239 Walker A/P-loop; other site 324602005240 ATP binding site [chemical binding]; other site 324602005241 Q-loop/lid; other site 324602005242 ABC transporter signature motif; other site 324602005243 Walker B; other site 324602005244 D-loop; other site 324602005245 H-loop/switch region; other site 324602005246 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 324602005247 exonuclease subunit SbcD; Provisional; Region: PRK10966 324602005248 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 324602005249 active site 324602005250 metal binding site [ion binding]; metal-binding site 324602005251 DNA binding site [nucleotide binding] 324602005252 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324602005253 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324602005254 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324602005255 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 324602005256 inhibitor-cofactor binding pocket; inhibition site 324602005257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602005258 catalytic residue [active] 324602005259 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324602005260 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324602005261 NAD(P) binding site [chemical binding]; other site 324602005262 active site 324602005263 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 324602005264 inhibitor-cofactor binding pocket; inhibition site 324602005265 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602005266 catalytic residue [active] 324602005267 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 324602005268 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 324602005269 active site 324602005270 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 324602005271 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 324602005272 NodB motif; other site 324602005273 active site 324602005274 catalytic site [active] 324602005275 metal binding site [ion binding]; metal-binding site 324602005276 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 324602005277 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 324602005278 active site 324602005279 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 324602005280 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 324602005281 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 324602005282 active site 324602005283 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 324602005284 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 324602005285 active site 324602005286 Sugar-binding cellulase-like; Region: Cellulase-like; cl19200 324602005287 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 324602005288 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 324602005289 trimer interface [polypeptide binding]; other site 324602005290 active site 324602005291 substrate binding site [chemical binding]; other site 324602005292 CoA binding site [chemical binding]; other site 324602005293 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 324602005294 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 324602005295 active site 324602005296 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 324602005297 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 324602005298 trimer interface [polypeptide binding]; other site 324602005299 active site 324602005300 substrate binding site [chemical binding]; other site 324602005301 CoA binding site [chemical binding]; other site 324602005302 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324602005303 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602005304 Sugar-binding cellulase-like; Region: Cellulase-like; cl19200 324602005305 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 324602005306 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324602005307 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602005308 homodimer interface [polypeptide binding]; other site 324602005309 catalytic residue [active] 324602005310 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 324602005311 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 324602005312 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 324602005313 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 324602005314 PAS fold; Region: PAS; pfam00989 324602005315 PAS domain; Region: PAS_8; pfam13188 324602005316 GAF domain; Region: GAF_2; pfam13185 324602005317 GAF domain; Region: GAF_2; pfam13185 324602005318 GAF domain; Region: GAF_2; pfam13185 324602005319 GAF domain; Region: GAF; cl17456 324602005320 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324602005321 metal binding site [ion binding]; metal-binding site 324602005322 active site 324602005323 I-site; other site 324602005324 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 324602005325 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 324602005326 catalytic core [active] 324602005327 conserved hypothetical protein; Region: TIGR03847 324602005328 conserved hypothetical protein; Region: TIGR03843 324602005329 PAS fold; Region: PAS; pfam00989 324602005330 PAS domain; Region: PAS_8; pfam13188 324602005331 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 324602005332 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 324602005333 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 324602005334 Walker A/P-loop; other site 324602005335 ATP binding site [chemical binding]; other site 324602005336 Q-loop/lid; other site 324602005337 ABC transporter signature motif; other site 324602005338 Walker B; other site 324602005339 D-loop; other site 324602005340 H-loop/switch region; other site 324602005341 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 324602005342 Walker A/P-loop; other site 324602005343 ATP binding site [chemical binding]; other site 324602005344 Q-loop/lid; other site 324602005345 ABC transporter signature motif; other site 324602005346 Walker B; other site 324602005347 D-loop; other site 324602005348 H-loop/switch region; other site 324602005349 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 324602005350 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324602005351 catalytic residue [active] 324602005352 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 324602005353 putative active site [active] 324602005354 catalytic residue [active] 324602005355 methionine sulfoxide reductase A; Provisional; Region: PRK14054 324602005356 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 324602005357 active site 324602005358 NAD binding site [chemical binding]; other site 324602005359 metal binding site [ion binding]; metal-binding site 324602005360 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 324602005361 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 324602005362 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 324602005363 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 324602005364 dimer interface [polypeptide binding]; other site 324602005365 putative CheW interface [polypeptide binding]; other site 324602005366 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 324602005367 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 324602005368 putative binding surface; other site 324602005369 active site 324602005370 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 324602005371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602005372 ATP binding site [chemical binding]; other site 324602005373 Mg2+ binding site [ion binding]; other site 324602005374 G-X-G motif; other site 324602005375 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 324602005376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602005377 active site 324602005378 phosphorylation site [posttranslational modification] 324602005379 intermolecular recognition site; other site 324602005380 dimerization interface [polypeptide binding]; other site 324602005381 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602005382 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602005383 active site 324602005384 phosphorylation site [posttranslational modification] 324602005385 intermolecular recognition site; other site 324602005386 dimerization interface [polypeptide binding]; other site 324602005387 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 324602005388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602005389 active site 324602005390 phosphorylation site [posttranslational modification] 324602005391 intermolecular recognition site; other site 324602005392 dimerization interface [polypeptide binding]; other site 324602005393 CheB methylesterase; Region: CheB_methylest; pfam01339 324602005394 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 324602005395 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 324602005396 Tetratricopeptide repeat; Region: TPR_16; pfam13432 324602005397 TPR repeat; Region: TPR_11; pfam13414 324602005398 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602005399 TPR motif; other site 324602005400 binding surface 324602005401 TPR repeat; Region: TPR_11; pfam13414 324602005402 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 324602005403 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 324602005404 TPR repeat; Region: TPR_11; pfam13414 324602005405 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602005406 binding surface 324602005407 TPR motif; other site 324602005408 TPR repeat; Region: TPR_11; pfam13414 324602005409 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602005410 binding surface 324602005411 TPR motif; other site 324602005412 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 324602005413 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602005414 binding surface 324602005415 TPR motif; other site 324602005416 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602005417 binding surface 324602005418 TPR motif; other site 324602005419 TPR repeat; Region: TPR_11; pfam13414 324602005420 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602005421 binding surface 324602005422 Tetratricopeptide repeat; Region: TPR_16; pfam13432 324602005423 TPR motif; other site 324602005424 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 324602005425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602005426 ATP binding site [chemical binding]; other site 324602005427 Mg2+ binding site [ion binding]; other site 324602005428 G-X-G motif; other site 324602005429 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 324602005430 anti sigma factor interaction site; other site 324602005431 regulatory phosphorylation site [posttranslational modification]; other site 324602005432 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 324602005433 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 324602005434 dimer interface [polypeptide binding]; other site 324602005435 NAD binding site [chemical binding]; other site 324602005436 substrate binding site [chemical binding]; other site 324602005437 tetramer (dimer of dimers) interface [polypeptide binding]; other site 324602005438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602005439 active site 324602005440 phosphorylation site [posttranslational modification] 324602005441 intermolecular recognition site; other site 324602005442 dimerization interface [polypeptide binding]; other site 324602005443 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 324602005444 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602005445 active site 324602005446 phosphorylation site [posttranslational modification] 324602005447 intermolecular recognition site; other site 324602005448 dimerization interface [polypeptide binding]; other site 324602005449 GAF domain; Region: GAF_3; pfam13492 324602005450 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324602005451 Zn2+ binding site [ion binding]; other site 324602005452 Mg2+ binding site [ion binding]; other site 324602005453 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 324602005454 Restriction endonuclease; Region: Mrr_cat; pfam04471 324602005455 Bacterial SH3 domain; Region: SH3_3; pfam08239 324602005456 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 324602005457 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 324602005458 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 324602005459 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 324602005460 Walker A/P-loop; other site 324602005461 ATP binding site [chemical binding]; other site 324602005462 Q-loop/lid; other site 324602005463 ABC transporter signature motif; other site 324602005464 Walker B; other site 324602005465 D-loop; other site 324602005466 H-loop/switch region; other site 324602005467 TOBE domain; Region: TOBE_2; pfam08402 324602005468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602005469 dimer interface [polypeptide binding]; other site 324602005470 conserved gate region; other site 324602005471 putative PBP binding loops; other site 324602005472 ABC-ATPase subunit interface; other site 324602005473 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 324602005474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602005475 dimer interface [polypeptide binding]; other site 324602005476 conserved gate region; other site 324602005477 putative PBP binding loops; other site 324602005478 ABC-ATPase subunit interface; other site 324602005479 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 324602005480 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 324602005481 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 324602005482 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324602005483 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324602005484 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 324602005485 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324602005486 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324602005487 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324602005488 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324602005489 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324602005490 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324602005491 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 324602005492 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 324602005493 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 324602005494 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324602005495 Q-loop/lid; other site 324602005496 ABC transporter signature motif; other site 324602005497 Walker B; other site 324602005498 D-loop; other site 324602005499 H-loop/switch region; other site 324602005500 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 324602005501 Domain of unknown function (DUF333); Region: DUF333; pfam03891 324602005502 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 324602005503 Uncharacterized conserved protein [Function unknown]; Region: COG2128 324602005504 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 324602005505 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 324602005506 E3 interaction surface; other site 324602005507 lipoyl attachment site [posttranslational modification]; other site 324602005508 e3 binding domain; Region: E3_binding; pfam02817 324602005509 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 324602005510 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 324602005511 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 324602005512 alpha subunit interface [polypeptide binding]; other site 324602005513 TPP binding site [chemical binding]; other site 324602005514 heterodimer interface [polypeptide binding]; other site 324602005515 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 324602005516 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 324602005517 tetramer interface [polypeptide binding]; other site 324602005518 TPP-binding site [chemical binding]; other site 324602005519 heterodimer interface [polypeptide binding]; other site 324602005520 phosphorylation loop region [posttranslational modification] 324602005521 TPR repeat; Region: TPR_11; pfam13414 324602005522 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 324602005523 Glyco_18 domain; Region: Glyco_18; smart00636 324602005524 active site 324602005525 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 324602005526 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 324602005527 oligomer interface [polypeptide binding]; other site 324602005528 active site 324602005529 metal binding site [ion binding]; metal-binding site 324602005530 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 324602005531 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 324602005532 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 324602005533 NAD(P) binding site [chemical binding]; other site 324602005534 YtxH-like protein; Region: YtxH; cl02079 324602005535 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 324602005536 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 324602005537 ATP-binding site [chemical binding]; other site 324602005538 Sugar specificity; other site 324602005539 Pyrimidine base specificity; other site 324602005540 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 324602005541 Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or...; Region: DSPc; cl00053 324602005542 active site 324602005543 catalytic residues [active] 324602005544 putative acetyltransferase; Provisional; Region: PRK03624 324602005545 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324602005546 Coenzyme A binding pocket [chemical binding]; other site 324602005547 Bacterial SH3 domain; Region: SH3_3; pfam08239 324602005548 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602005549 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 324602005550 Transcriptional regulators [Transcription]; Region: MarR; COG1846 324602005551 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324602005552 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324602005553 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324602005554 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324602005555 Walker A/P-loop; other site 324602005556 ATP binding site [chemical binding]; other site 324602005557 Q-loop/lid; other site 324602005558 ABC transporter signature motif; other site 324602005559 Walker B; other site 324602005560 D-loop; other site 324602005561 H-loop/switch region; other site 324602005562 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324602005563 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324602005564 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324602005565 Walker A/P-loop; other site 324602005566 ATP binding site [chemical binding]; other site 324602005567 Q-loop/lid; other site 324602005568 ABC transporter signature motif; other site 324602005569 Walker B; other site 324602005570 D-loop; other site 324602005571 H-loop/switch region; other site 324602005572 Clostripain family; Region: Peptidase_C11; pfam03415 324602005573 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 324602005574 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 324602005575 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 324602005576 metal binding site 2 [ion binding]; metal-binding site 324602005577 putative DNA binding helix; other site 324602005578 metal binding site 1 [ion binding]; metal-binding site 324602005579 dimer interface [polypeptide binding]; other site 324602005580 structural Zn2+ binding site [ion binding]; other site 324602005581 Uncharacterized nucleotidyltransferase; Region: NTP_transf_5; pfam14907 324602005582 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 324602005583 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 324602005584 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 324602005585 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 324602005586 active site 324602005587 ATP binding site [chemical binding]; other site 324602005588 substrate binding site [chemical binding]; other site 324602005589 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 324602005590 Bacterial SH3 domain; Region: SH3_3; pfam08239 324602005591 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 324602005592 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 324602005593 inhibitor-cofactor binding pocket; inhibition site 324602005594 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602005595 catalytic residue [active] 324602005596 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 324602005597 Peptidase family M50; Region: Peptidase_M50; pfam02163 324602005598 active site 324602005599 putative substrate binding region [chemical binding]; other site 324602005600 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 324602005601 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 324602005602 ligand binding site [chemical binding]; other site 324602005603 flexible hinge region; other site 324602005604 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 324602005605 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 324602005606 ligand binding site [chemical binding]; other site 324602005607 flexible hinge region; other site 324602005608 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 324602005609 substrate binding site [chemical binding]; other site 324602005610 dimer interface [polypeptide binding]; other site 324602005611 ATP binding site [chemical binding]; other site 324602005612 Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041 324602005613 Lysine biosynthesis protein LysW; Region: LysW; cl11748 324602005614 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 324602005615 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 324602005616 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 324602005617 P loop; other site 324602005618 GTP binding site [chemical binding]; other site 324602005619 Putative lysophospholipase; Region: Hydrolase_4; cl19140 324602005620 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324602005621 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 324602005622 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 324602005623 catalytic loop [active] 324602005624 iron binding site [ion binding]; other site 324602005625 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 324602005626 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 324602005627 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 324602005628 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 324602005629 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 324602005630 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 324602005631 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 324602005632 Protein of unknown function (DUF512); Region: DUF512; pfam04459 324602005633 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 324602005634 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 324602005635 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 324602005636 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324602005637 Zn2+ binding site [ion binding]; other site 324602005638 Mg2+ binding site [ion binding]; other site 324602005639 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 324602005640 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 324602005641 glutamine binding [chemical binding]; other site 324602005642 catalytic triad [active] 324602005643 short chain dehydrogenase; Provisional; Region: PRK06172 324602005644 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324602005645 NAD(P) binding site [chemical binding]; other site 324602005646 active site 324602005647 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 324602005648 DNA binding site [nucleotide binding] 324602005649 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 324602005650 active site 324602005651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602005652 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 324602005653 putative substrate translocation pore; other site 324602005654 Putative lysophospholipase; Region: Hydrolase_4; cl19140 324602005655 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324602005656 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 324602005657 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 324602005658 Ubiquitin-like proteins; Region: UBQ; cl00155 324602005659 hydrophobic patch; other site 324602005660 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 324602005661 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 324602005662 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 324602005663 Walker A/P-loop; other site 324602005664 ATP binding site [chemical binding]; other site 324602005665 Q-loop/lid; other site 324602005666 ABC transporter signature motif; other site 324602005667 Walker B; other site 324602005668 D-loop; other site 324602005669 H-loop/switch region; other site 324602005670 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 324602005671 putative carbohydrate binding site [chemical binding]; other site 324602005672 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324602005673 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602005674 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 324602005675 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 324602005676 Probable Catalytic site; other site 324602005677 metal-binding site 324602005678 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 324602005679 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 324602005680 Probable Catalytic site; other site 324602005681 metal-binding site 324602005682 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602005683 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324602005684 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602005685 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324602005686 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 324602005687 FOG: WD40-like repeat [Function unknown]; Region: COG1520 324602005688 active site 324602005689 Trp docking motif [polypeptide binding]; other site 324602005690 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 324602005691 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 324602005692 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324602005693 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324602005694 NAD(P) binding site [chemical binding]; other site 324602005695 active site 324602005696 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602005697 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324602005698 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 324602005699 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324602005700 catalytic residue [active] 324602005701 Putative lysophospholipase; Region: Hydrolase_4; cl19140 324602005702 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324602005703 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 324602005704 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 324602005705 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 324602005706 active site 324602005707 dimer interface [polypeptide binding]; other site 324602005708 effector binding site; other site 324602005709 TSCPD domain; Region: TSCPD; pfam12637 324602005710 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 324602005711 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 324602005712 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 324602005713 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 324602005714 TrkA-N domain; Region: TrkA_N; pfam02254 324602005715 TrkA-N domain; Region: TrkA_N; pfam02254 324602005716 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 324602005717 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 324602005718 active site 324602005719 Membrane transport protein; Region: Mem_trans; cl09117 324602005720 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 324602005721 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 324602005722 Zinc ribbon domain; Region: Zn-ribbon_8; pfam09723 324602005723 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 324602005724 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 324602005725 active site 324602005726 Substrate binding site; other site 324602005727 Mg++ binding site; other site 324602005728 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 324602005729 putative trimer interface [polypeptide binding]; other site 324602005730 putative CoA binding site [chemical binding]; other site 324602005731 Domain of unknown function (DUF3524); Region: DUF3524; pfam12038 324602005732 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602005733 Glycosyl transferases group 1; Region: Glycos_transf_1; cl19138 324602005734 LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cd08368 324602005735 Zn binding site [ion binding]; other site 324602005736 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 324602005737 Predicted esterase [General function prediction only]; Region: COG0400 324602005738 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 324602005739 DEC-1 protein, N-terminal region; Region: DEC-1_N; pfam04625 324602005740 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 324602005741 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324602005742 Transcriptional regulator [Transcription]; Region: LytR; COG1316 324602005743 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 324602005744 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 324602005745 Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like; Region: ALDH_AldH-CAJ73105; cd07131 324602005746 NAD binding site [chemical binding]; other site 324602005747 catalytic residues [active] 324602005748 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 324602005749 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 324602005750 Cache domain; Region: Cache_1; pfam02743 324602005751 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324602005752 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324602005753 dimerization interface [polypeptide binding]; other site 324602005754 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602005755 dimer interface [polypeptide binding]; other site 324602005756 phosphorylation site [posttranslational modification] 324602005757 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602005758 ATP binding site [chemical binding]; other site 324602005759 Mg2+ binding site [ion binding]; other site 324602005760 G-X-G motif; other site 324602005761 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602005762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602005763 active site 324602005764 phosphorylation site [posttranslational modification] 324602005765 intermolecular recognition site; other site 324602005766 dimerization interface [polypeptide binding]; other site 324602005767 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602005768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602005769 active site 324602005770 phosphorylation site [posttranslational modification] 324602005771 intermolecular recognition site; other site 324602005772 dimerization interface [polypeptide binding]; other site 324602005773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602005774 active site 324602005775 phosphorylation site [posttranslational modification] 324602005776 intermolecular recognition site; other site 324602005777 dimerization interface [polypeptide binding]; other site 324602005778 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 324602005779 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 324602005780 ATP-grasp domain; Region: ATP-grasp_4; cl17255 324602005781 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 324602005782 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 324602005783 ATP-grasp domain; Region: ATP-grasp_4; cl17255 324602005784 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 324602005785 IMP binding site; other site 324602005786 dimer interface [polypeptide binding]; other site 324602005787 interdomain contacts; other site 324602005788 partial ornithine binding site; other site 324602005789 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324602005790 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324602005791 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 324602005792 Walker A/P-loop; other site 324602005793 ATP binding site [chemical binding]; other site 324602005794 Q-loop/lid; other site 324602005795 ABC transporter signature motif; other site 324602005796 Walker B; other site 324602005797 D-loop; other site 324602005798 H-loop/switch region; other site 324602005799 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324602005800 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324602005801 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324602005802 Walker A/P-loop; other site 324602005803 ATP binding site [chemical binding]; other site 324602005804 Q-loop/lid; other site 324602005805 ABC transporter signature motif; other site 324602005806 Walker B; other site 324602005807 D-loop; other site 324602005808 H-loop/switch region; other site 324602005809 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 324602005810 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 324602005811 phosphopeptide binding site; other site 324602005812 Clostripain family; Region: Peptidase_C11; pfam03415 324602005813 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602005814 dimer interface [polypeptide binding]; other site 324602005815 phosphorylation site [posttranslational modification] 324602005816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602005817 ATP binding site [chemical binding]; other site 324602005818 Mg2+ binding site [ion binding]; other site 324602005819 G-X-G motif; other site 324602005820 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 324602005821 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651 324602005822 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 324602005823 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324602005824 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324602005825 LysR substrate binding domain; Region: LysR_substrate; pfam03466 324602005826 dimerization interface [polypeptide binding]; other site 324602005827 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 324602005828 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 324602005829 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 324602005830 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 324602005831 putative symporter YagG; Provisional; Region: PRK09669; cl15392 324602005832 Domain of unknown function (DUF897); Region: DUF897; cl01312 324602005833 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 324602005834 phosphate binding site [ion binding]; other site 324602005835 putative substrate binding pocket [chemical binding]; other site 324602005836 dimer interface [polypeptide binding]; other site 324602005837 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 324602005838 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324602005839 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602005840 TPR repeat; Region: TPR_11; pfam13414 324602005841 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602005842 binding surface 324602005843 TPR motif; other site 324602005844 TPR repeat; Region: TPR_11; pfam13414 324602005845 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602005846 binding surface 324602005847 TPR motif; other site 324602005848 TPR repeat; Region: TPR_11; pfam13414 324602005849 TPR repeat; Region: TPR_11; pfam13414 324602005850 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602005851 TPR motif; other site 324602005852 binding surface 324602005853 TPR repeat; Region: TPR_11; pfam13414 324602005854 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602005855 binding surface 324602005856 TPR motif; other site 324602005857 TPR repeat; Region: TPR_11; pfam13414 324602005858 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602005859 binding surface 324602005860 TPR repeat; Region: TPR_11; pfam13414 324602005861 TPR motif; other site 324602005862 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 324602005863 putative MPT binding site; other site 324602005864 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 324602005865 prolyl-tRNA synthetase; Provisional; Region: PRK09194 324602005866 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 324602005867 motif 1; other site 324602005868 dimer interface [polypeptide binding]; other site 324602005869 Mitochondrial fission regulator; Region: Mito_fiss_reg; pfam05308 324602005870 motif 2; other site 324602005871 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 324602005872 putative deacylase active site [active] 324602005873 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 324602005874 anticodon binding site; other site 324602005875 Protein of unknown function DUF72; Region: DUF72; pfam01904 324602005876 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 324602005877 Glutamate binding site [chemical binding]; other site 324602005878 homodimer interface [polypeptide binding]; other site 324602005879 NAD binding site [chemical binding]; other site 324602005880 catalytic residues [active] 324602005881 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 324602005882 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 324602005883 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 324602005884 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 324602005885 alanine racemase; Reviewed; Region: alr; PRK00053 324602005886 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 324602005887 active site 324602005888 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 324602005889 dimer interface [polypeptide binding]; other site 324602005890 substrate binding site [chemical binding]; other site 324602005891 catalytic residues [active] 324602005892 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 324602005893 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 324602005894 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 324602005895 active site 324602005896 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 324602005897 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602005898 active site 324602005899 phosphorylation site [posttranslational modification] 324602005900 intermolecular recognition site; other site 324602005901 dimerization interface [polypeptide binding]; other site 324602005902 ANTAR domain; Region: ANTAR; pfam03861 324602005903 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 324602005904 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 324602005905 active site 324602005906 Substrate binding site; other site 324602005907 Mg++ binding site; other site 324602005908 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 324602005909 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 324602005910 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324602005911 Walker A/P-loop; other site 324602005912 ATP binding site [chemical binding]; other site 324602005913 Q-loop/lid; other site 324602005914 ABC transporter signature motif; other site 324602005915 Walker B; other site 324602005916 D-loop; other site 324602005917 H-loop/switch region; other site 324602005918 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602005919 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324602005920 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 324602005921 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324602005922 catalytic residue [active] 324602005923 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 324602005924 Domain interface; other site 324602005925 C-terminal peptidase (prc); Region: prc; TIGR00225 324602005926 Active site tetrad [active] 324602005927 Peptide binding site; other site 324602005928 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 324602005929 protein binding site [polypeptide binding]; other site 324602005930 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 324602005931 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 324602005932 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 324602005933 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 324602005934 Transcriptional regulators [Transcription]; Region: MarR; COG1846 324602005935 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324602005936 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 324602005937 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 324602005938 active site 324602005939 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 324602005940 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 324602005941 Cysteine-rich domain; Region: CCG; pfam02754 324602005942 Cysteine-rich domain; Region: CCG; pfam02754 324602005943 HsdM N-terminal domain; Region: HsdM_N; pfam12161 324602005944 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 324602005945 Methyltransferase domain; Region: Methyltransf_26; pfam13659 324602005946 Domain of unknown function (DUF955); Region: DUF955; cl01076 324602005947 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 324602005948 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 324602005949 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 324602005950 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 324602005951 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 324602005952 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 324602005953 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324602005954 ATP binding site [chemical binding]; other site 324602005955 putative Mg++ binding site [ion binding]; other site 324602005956 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 324602005957 FOG: CBS domain [General function prediction only]; Region: COG0517 324602005958 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 324602005959 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 324602005960 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 324602005961 putative active site [active] 324602005962 TolA protein; Region: tolA_full; TIGR02794 324602005963 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 324602005964 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 324602005965 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 324602005966 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 324602005967 Uncharacterized conserved protein [Function unknown]; Region: COG2353 324602005968 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 324602005969 catalytic residues [active] 324602005970 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 324602005971 Thioredoxin; Region: Thioredoxin_4; pfam13462 324602005972 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 324602005973 active site 324602005974 ATP binding site [chemical binding]; other site 324602005975 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 324602005976 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 324602005977 TPP-binding site [chemical binding]; other site 324602005978 dimer interface [polypeptide binding]; other site 324602005979 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 324602005980 PYR/PP interface [polypeptide binding]; other site 324602005981 dimer interface [polypeptide binding]; other site 324602005982 TPP binding site [chemical binding]; other site 324602005983 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 324602005984 substrate binding site [chemical binding]; other site 324602005985 glutamase interaction surface [polypeptide binding]; other site 324602005986 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 324602005987 SpaB C-terminal domain; Region: SpaB_C; cl14828 324602005988 GAF domain; Region: GAF_3; pfam13492 324602005989 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 324602005990 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602005991 dimer interface [polypeptide binding]; other site 324602005992 phosphorylation site [posttranslational modification] 324602005993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602005994 ATP binding site [chemical binding]; other site 324602005995 Mg2+ binding site [ion binding]; other site 324602005996 G-X-G motif; other site 324602005997 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602005998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602005999 active site 324602006000 phosphorylation site [posttranslational modification] 324602006001 intermolecular recognition site; other site 324602006002 dimerization interface [polypeptide binding]; other site 324602006003 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324602006004 DNA binding site [nucleotide binding] 324602006005 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 324602006006 Part of AAA domain; Region: AAA_19; pfam13245 324602006007 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 324602006008 Protein kinase domain; Region: Pkinase; pfam00069 324602006009 Catalytic domain of Protein Kinases; Region: PKc; cd00180 324602006010 active site 324602006011 ATP binding site [chemical binding]; other site 324602006012 substrate binding site [chemical binding]; other site 324602006013 activation loop (A-loop); other site 324602006014 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 324602006015 Zn binding sites [ion binding]; other site 324602006016 C-terminal peptidase (prc); Region: prc; TIGR00225 324602006017 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 324602006018 protein binding site [polypeptide binding]; other site 324602006019 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 324602006020 Catalytic dyad [active] 324602006021 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 324602006022 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 324602006023 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057 324602006024 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 324602006025 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 324602006026 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602006027 S-adenosylmethionine binding site [chemical binding]; other site 324602006028 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 324602006029 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 324602006030 active site 324602006031 HIGH motif; other site 324602006032 KMSKS motif; other site 324602006033 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 324602006034 tRNA binding surface [nucleotide binding]; other site 324602006035 anticodon binding site; other site 324602006036 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 324602006037 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 324602006038 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 324602006039 trimer interface [polypeptide binding]; other site 324602006040 active site 324602006041 substrate binding site [chemical binding]; other site 324602006042 CoA binding site [chemical binding]; other site 324602006043 Zinc ribbon domain; Region: Zn-ribbon_8; cl00993 324602006044 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 324602006045 DNA-binding site [nucleotide binding]; DNA binding site 324602006046 RNA-binding motif; other site 324602006047 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 324602006048 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 324602006049 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 324602006050 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 324602006051 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 324602006052 Poxvirus J1 protein; Region: Pox_J1; pfam03338 324602006053 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 324602006054 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 324602006055 active site 324602006056 putative substrate binding pocket [chemical binding]; other site 324602006057 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 324602006058 Mrr N-terminal domain; Region: Mrr_N; pfam14338 324602006059 Predicted transcriptional regulators [Transcription]; Region: COG1695 324602006060 Restriction endonuclease; Region: Mrr_cat; pfam04471 324602006061 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 324602006062 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324602006063 non-specific DNA binding site [nucleotide binding]; other site 324602006064 salt bridge; other site 324602006065 sequence-specific DNA binding site [nucleotide binding]; other site 324602006066 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 324602006067 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 324602006068 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 324602006069 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 324602006070 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324602006071 FeS/SAM binding site; other site 324602006072 Penicillinase repressor; Region: Penicillinase_R; pfam03965 324602006073 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 324602006074 substrate binding pocket [chemical binding]; other site 324602006075 chain length determination region; other site 324602006076 substrate-Mg2+ binding site; other site 324602006077 catalytic residues [active] 324602006078 aspartate-rich region 1; other site 324602006079 active site lid residues [active] 324602006080 aspartate-rich region 2; other site 324602006081 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 324602006082 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 324602006083 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 324602006084 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 324602006085 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 324602006086 putative active site [active] 324602006087 Zn binding site [ion binding]; other site 324602006088 RNA polymerase sigma factor; Provisional; Region: PRK12519 324602006089 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324602006090 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324602006091 DNA binding residues [nucleotide binding] 324602006092 putative anti-sigmaE protein; Provisional; Region: PRK13920 324602006093 Anti-sigma-K factor rskA; Region: RskA; pfam10099 324602006094 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602006095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602006096 active site 324602006097 phosphorylation site [posttranslational modification] 324602006098 intermolecular recognition site; other site 324602006099 dimerization interface [polypeptide binding]; other site 324602006100 GAF domain; Region: GAF; pfam01590 324602006101 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 324602006102 GAF domain; Region: GAF_3; pfam13492 324602006103 PAS domain; Region: PAS_9; pfam13426 324602006104 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 324602006105 cyclase homology domain; Region: CHD; cd07302 324602006106 nucleotidyl binding site; other site 324602006107 metal binding site [ion binding]; metal-binding site 324602006108 dimer interface [polypeptide binding]; other site 324602006109 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 324602006110 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 324602006111 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 324602006112 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 324602006113 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 324602006114 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 324602006115 amidase catalytic site [active] 324602006116 Zn binding residues [ion binding]; other site 324602006117 substrate binding site [chemical binding]; other site 324602006118 MoxR-like ATPases [General function prediction only]; Region: COG0714 324602006119 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602006120 Walker A motif; other site 324602006121 ATP binding site [chemical binding]; other site 324602006122 Walker B motif; other site 324602006123 arginine finger; other site 324602006124 DNA photolyase; Region: DNA_photolyase; pfam00875 324602006125 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 324602006126 classical (c) SDRs; Region: SDR_c; cd05233 324602006127 NAD(P) binding site [chemical binding]; other site 324602006128 active site 324602006129 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 324602006130 MoaE interaction surface [polypeptide binding]; other site 324602006131 MoeB interaction surface [polypeptide binding]; other site 324602006132 thiocarboxylated glycine; other site 324602006133 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 324602006134 MoaE homodimer interface [polypeptide binding]; other site 324602006135 MoaD interaction [polypeptide binding]; other site 324602006136 active site residues [active] 324602006137 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 324602006138 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 324602006139 DNA binding site [nucleotide binding] 324602006140 catalytic residue [active] 324602006141 H2TH interface [polypeptide binding]; other site 324602006142 putative catalytic residues [active] 324602006143 turnover-facilitating residue; other site 324602006144 intercalation triad [nucleotide binding]; other site 324602006145 8OG recognition residue [nucleotide binding]; other site 324602006146 putative reading head residues; other site 324602006147 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 324602006148 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 324602006149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602006150 active site 324602006151 phosphorylation site [posttranslational modification] 324602006152 intermolecular recognition site; other site 324602006153 dimerization interface [polypeptide binding]; other site 324602006154 Predicted ATPase [General function prediction only]; Region: COG4637 324602006155 AAA domain; Region: AAA_23; pfam13476 324602006156 Walker A/P-loop; other site 324602006157 ATP binding site [chemical binding]; other site 324602006158 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 324602006159 ABC transporter signature motif; other site 324602006160 Walker B; other site 324602006161 D-loop; other site 324602006162 H-loop/switch region; other site 324602006163 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324602006164 Zn2+ binding site [ion binding]; other site 324602006165 Mg2+ binding site [ion binding]; other site 324602006166 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 324602006167 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324602006168 catalytic residue [active] 324602006169 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 324602006170 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602006171 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 324602006172 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 324602006173 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 324602006174 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 324602006175 L-aspartate oxidase; Provisional; Region: PRK06175 324602006176 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 324602006177 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 324602006178 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 324602006179 putative Iron-sulfur protein interface [polypeptide binding]; other site 324602006180 proximal heme binding site [chemical binding]; other site 324602006181 distal heme binding site [chemical binding]; other site 324602006182 putative dimer interface [polypeptide binding]; other site 324602006183 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 324602006184 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 324602006185 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 324602006186 Peptidase family M23; Region: Peptidase_M23; pfam01551 324602006187 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602006188 TPR motif; other site 324602006189 TPR repeat; Region: TPR_11; pfam13414 324602006190 binding surface 324602006191 TPR repeat; Region: TPR_11; pfam13414 324602006192 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602006193 binding surface 324602006194 TPR motif; other site 324602006195 acyl-CoA synthetase; Validated; Region: PRK08162 324602006196 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 324602006197 acyl-activating enzyme (AAE) consensus motif; other site 324602006198 putative active site [active] 324602006199 AMP binding site [chemical binding]; other site 324602006200 putative CoA binding site [chemical binding]; other site 324602006201 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 324602006202 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324602006203 active site 324602006204 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 324602006205 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 324602006206 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 324602006207 dihydroorotase; Validated; Region: pyrC; PRK09357 324602006208 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 324602006209 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 324602006210 active site 324602006211 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 324602006212 Pleckstrin homology-like domain; Region: PH-like; cl17171 324602006213 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 324602006214 active site 324602006215 Zn binding site [ion binding]; other site 324602006216 aminotransferase; Validated; Region: PRK07777 324602006217 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324602006218 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602006219 homodimer interface [polypeptide binding]; other site 324602006220 catalytic residue [active] 324602006221 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 324602006222 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 324602006223 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 324602006224 trimer interface [polypeptide binding]; other site 324602006225 active site 324602006226 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 324602006227 catalytic site [active] 324602006228 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl17552 324602006229 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 324602006230 active site 324602006231 NTP binding site [chemical binding]; other site 324602006232 metal binding triad [ion binding]; metal-binding site 324602006233 antibiotic binding site [chemical binding]; other site 324602006234 AAA ATPase domain; Region: AAA_15; pfam13175 324602006235 AAA domain; Region: AAA_23; pfam13476 324602006236 AAA domain; Region: AAA_21; pfam13304 324602006237 Walker A/P-loop; other site 324602006238 ATP binding site [chemical binding]; other site 324602006239 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 324602006240 ABC transporter signature motif; other site 324602006241 Walker B; other site 324602006242 D-loop; other site 324602006243 H-loop/switch region; other site 324602006244 Transglycosylase; Region: Transgly; pfam00912 324602006245 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 324602006246 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 324602006247 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 324602006248 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 324602006249 CoA-binding site [chemical binding]; other site 324602006250 ATP-binding [chemical binding]; other site 324602006251 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 324602006252 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 324602006253 active site 324602006254 putative substrate binding pocket [chemical binding]; other site 324602006255 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 324602006256 putative active site; other site 324602006257 putative metal binding residues [ion binding]; other site 324602006258 signature motif; other site 324602006259 putative triphosphate binding site [ion binding]; other site 324602006260 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 324602006261 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 324602006262 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 324602006263 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 324602006264 hinge; other site 324602006265 active site 324602006266 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 324602006267 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 324602006268 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 324602006269 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 324602006270 catalytic triad [active] 324602006271 putative active site [active] 324602006272 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 324602006273 PA/protease or protease-like domain interface [polypeptide binding]; other site 324602006274 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 324602006275 aspartate aminotransferase; Provisional; Region: PRK05764 324602006276 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324602006277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602006278 homodimer interface [polypeptide binding]; other site 324602006279 catalytic residue [active] 324602006280 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324602006281 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324602006282 DNA binding residues [nucleotide binding] 324602006283 dimerization interface [polypeptide binding]; other site 324602006284 Kelch domain; Region: Kelch; smart00612 324602006285 Kelch domain; Region: Kelch; smart00612 324602006286 Kelch domain; Region: Kelch; smart00612 324602006287 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324602006288 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602006289 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602006290 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 324602006291 Uncharacterized membrane protein, required for N-linked glycosylation [General function prediction only]; Region: COG1287 324602006292 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 324602006293 homoserine dehydrogenase; Provisional; Region: PRK06270 324602006294 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 324602006295 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 324602006296 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 324602006297 AAA ATPase domain; Region: AAA_16; pfam13191 324602006298 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324602006299 DNA binding residues [nucleotide binding] 324602006300 dimerization interface [polypeptide binding]; other site 324602006301 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 324602006302 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 324602006303 putative ligand binding site [chemical binding]; other site 324602006304 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 324602006305 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 324602006306 Walker A/P-loop; other site 324602006307 ATP binding site [chemical binding]; other site 324602006308 Q-loop/lid; other site 324602006309 ABC transporter signature motif; other site 324602006310 Walker B; other site 324602006311 D-loop; other site 324602006312 H-loop/switch region; other site 324602006313 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 324602006314 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 324602006315 TM-ABC transporter signature motif; other site 324602006316 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324602006317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602006318 active site 324602006319 phosphorylation site [posttranslational modification] 324602006320 intermolecular recognition site; other site 324602006321 dimerization interface [polypeptide binding]; other site 324602006322 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324602006323 DNA binding residues [nucleotide binding] 324602006324 dimerization interface [polypeptide binding]; other site 324602006325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602006326 active site 324602006327 phosphorylation site [posttranslational modification] 324602006328 intermolecular recognition site; other site 324602006329 dimerization interface [polypeptide binding]; other site 324602006330 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 324602006331 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324602006332 Walker A/P-loop; other site 324602006333 ATP binding site [chemical binding]; other site 324602006334 Q-loop/lid; other site 324602006335 ABC transporter signature motif; other site 324602006336 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 324602006337 Walker B; other site 324602006338 D-loop; other site 324602006339 H-loop/switch region; other site 324602006340 Histidine kinase; Region: HisKA_3; pfam07730 324602006341 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602006342 ATP binding site [chemical binding]; other site 324602006343 Mg2+ binding site [ion binding]; other site 324602006344 G-X-G motif; other site 324602006345 DEAD-like helicases superfamily; Region: DEXDc; smart00487 324602006346 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324602006347 ATP binding site [chemical binding]; other site 324602006348 putative Mg++ binding site [ion binding]; other site 324602006349 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324602006350 ATP-binding site [chemical binding]; other site 324602006351 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 324602006352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602006353 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 324602006354 Walker A motif; other site 324602006355 ATP binding site [chemical binding]; other site 324602006356 Walker B motif; other site 324602006357 arginine finger; other site 324602006358 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 324602006359 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 324602006360 dimer interface [polypeptide binding]; other site 324602006361 active site 324602006362 histidinol-phosphate aminotransferase; Provisional; Region: PLN03026 324602006363 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324602006364 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602006365 homodimer interface [polypeptide binding]; other site 324602006366 catalytic residue [active] 324602006367 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 324602006368 active site 324602006369 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 324602006370 putative metal binding site [ion binding]; other site 324602006371 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 324602006372 putative active site pocket [active] 324602006373 4-fold oligomerization interface [polypeptide binding]; other site 324602006374 metal binding residues [ion binding]; metal-binding site 324602006375 3-fold/trimer interface [polypeptide binding]; other site 324602006376 Protease prsW family; Region: PrsW-protease; pfam13367 324602006377 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 324602006378 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 324602006379 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 324602006380 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 324602006381 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 324602006382 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 324602006383 inhibitor-cofactor binding pocket; inhibition site 324602006384 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602006385 catalytic residue [active] 324602006386 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 324602006387 GDP-binding site [chemical binding]; other site 324602006388 ACT binding site; other site 324602006389 IMP binding site; other site 324602006390 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 324602006391 active site 324602006392 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 324602006393 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 324602006394 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 324602006395 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 324602006396 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 324602006397 shikimate binding site; other site 324602006398 NAD(P) binding site [chemical binding]; other site 324602006399 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 324602006400 dimerization interface [polypeptide binding]; other site 324602006401 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602006402 binding surface 324602006403 TPR motif; other site 324602006404 TPR repeat; Region: TPR_11; pfam13414 324602006405 threonine synthase; Validated; Region: PRK06260 324602006406 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 324602006407 homodimer interface [polypeptide binding]; other site 324602006408 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602006409 catalytic residue [active] 324602006410 OPT oligopeptide transporter protein; Region: OPT; cl14607 324602006411 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 324602006412 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 324602006413 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602006414 S-adenosylmethionine binding site [chemical binding]; other site 324602006415 Auracyanins A and B and similar proteins; Region: Auracyanin; cd04233 324602006416 Type 1 (T1) Cu binding site [ion binding]; other site 324602006417 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 324602006418 EamA-like transporter family; Region: EamA; pfam00892 324602006419 EamA-like transporter family; Region: EamA; pfam00892 324602006420 Hpt domain; Region: Hpt; pfam01627 324602006421 putative binding surface; other site 324602006422 active site 324602006423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602006424 response regulator PleD; Reviewed; Region: pleD; PRK09581 324602006425 active site 324602006426 phosphorylation site [posttranslational modification] 324602006427 intermolecular recognition site; other site 324602006428 dimerization interface [polypeptide binding]; other site 324602006429 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602006430 active site 324602006431 phosphorylation site [posttranslational modification] 324602006432 intermolecular recognition site; other site 324602006433 dimerization interface [polypeptide binding]; other site 324602006434 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324602006435 metal binding site [ion binding]; metal-binding site 324602006436 active site 324602006437 I-site; other site 324602006438 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 324602006439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602006440 active site 324602006441 phosphorylation site [posttranslational modification] 324602006442 intermolecular recognition site; other site 324602006443 dimerization interface [polypeptide binding]; other site 324602006444 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 324602006445 Bacterial cellulose synthase subunit; Region: BcsB; pfam03170 324602006446 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 324602006447 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 324602006448 DXD motif; other site 324602006449 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 324602006450 anti sigma factor interaction site; other site 324602006451 regulatory phosphorylation site [posttranslational modification]; other site 324602006452 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 324602006453 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 324602006454 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 324602006455 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 324602006456 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 324602006457 putative active site [active] 324602006458 CpXC protein; Region: CpXC; pfam14353 324602006459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602006460 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 324602006461 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 324602006462 NADP binding site [chemical binding]; other site 324602006463 dimer interface [polypeptide binding]; other site 324602006464 aspartate kinase; Provisional; Region: PRK06291 324602006465 AAK_AK-LysC-like: Amino Acid Kinase Superfamily (AAK), AK-LysC-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive AK isoenzyme found in higher plants. The lysine-sensitive AK isoenzyme is a monofunctional...; Region: AAK_AK-LysC-like; cd04244 324602006466 putative catalytic residues [active] 324602006467 putative nucleotide binding site [chemical binding]; other site 324602006468 aspartate binding site [chemical binding]; other site 324602006469 dimer interface [polypeptide binding]; other site 324602006470 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 324602006471 dimer interface [polypeptide binding]; other site 324602006472 putative threonine allosteric regulatory site; other site 324602006473 ACT domains of a monofunctional aspartokinase found mostly in Archaea species (ACT_AK-Arch_2); Region: ACT_AK-Arch_2; cd04924 324602006474 Domain of unknown function (DUF4433); Region: DUF4433; pfam14487 324602006475 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 324602006476 ADP-ribose binding site [chemical binding]; other site 324602006477 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 324602006478 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 324602006479 inhibitor site; inhibition site 324602006480 active site 324602006481 dimer interface [polypeptide binding]; other site 324602006482 catalytic residue [active] 324602006483 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 324602006484 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 324602006485 substrate binding site; other site 324602006486 metal-binding site 324602006487 Oligomer interface; other site 324602006488 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 324602006489 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 324602006490 putative SAM binding site [chemical binding]; other site 324602006491 putative homodimer interface [polypeptide binding]; other site 324602006492 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 324602006493 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 324602006494 NADP-binding site; other site 324602006495 homotetramer interface [polypeptide binding]; other site 324602006496 substrate binding site [chemical binding]; other site 324602006497 homodimer interface [polypeptide binding]; other site 324602006498 active site 324602006499 FOG: CBS domain [General function prediction only]; Region: COG0517 324602006500 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 324602006501 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 324602006502 iron binding site [ion binding]; other site 324602006503 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 324602006504 tetramer interface [polypeptide binding]; other site 324602006505 TPP-binding site [chemical binding]; other site 324602006506 heterodimer interface [polypeptide binding]; other site 324602006507 phosphorylation loop region [posttranslational modification] 324602006508 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 324602006509 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 324602006510 alpha subunit interface [polypeptide binding]; other site 324602006511 TPP binding site [chemical binding]; other site 324602006512 heterodimer interface [polypeptide binding]; other site 324602006513 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 324602006514 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 324602006515 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 324602006516 E3 interaction surface; other site 324602006517 lipoyl attachment site [posttranslational modification]; other site 324602006518 e3 binding domain; Region: E3_binding; pfam02817 324602006519 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 324602006520 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 324602006521 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 324602006522 active site residue [active] 324602006523 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 324602006524 active site residue [active] 324602006525 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 324602006526 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 324602006527 NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; Region: NuoM; COG1008 324602006528 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 324602006529 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 324602006530 NADH-ubiquinone oxidoreductase chain 4, amino terminus; Region: Oxidored_q5_N; pfam01059 324602006531 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 324602006532 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 324602006533 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 324602006534 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 324602006535 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 324602006536 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 324602006537 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 324602006538 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 324602006539 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 324602006540 NADH dehydrogenase subunit D; Validated; Region: PRK06075 324602006541 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 324602006542 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 324602006543 NADH dehydrogenase subunit B; Provisional; Region: PRK14819 324602006544 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 324602006545 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 324602006546 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 324602006547 phosphopeptide binding site; other site 324602006548 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 324602006549 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 324602006550 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 324602006551 phosphopeptide binding site; other site 324602006552 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 324602006553 Glycoprotease family; Region: Peptidase_M22; pfam00814 324602006554 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 324602006555 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 324602006556 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324602006557 intersubunit interface [polypeptide binding]; other site 324602006558 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 324602006559 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 324602006560 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324602006561 ABC-ATPase subunit interface; other site 324602006562 dimer interface [polypeptide binding]; other site 324602006563 putative PBP binding regions; other site 324602006564 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; pfam09587 324602006565 active site 324602006566 metal binding site [ion binding]; metal-binding site 324602006567 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 324602006568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602006569 active site 324602006570 phosphorylation site [posttranslational modification] 324602006571 intermolecular recognition site; other site 324602006572 dimerization interface [polypeptide binding]; other site 324602006573 ANTAR domain; Region: ANTAR; pfam03861 324602006574 TMAO/DMSO reductase; Reviewed; Region: PRK05363 324602006575 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 324602006576 Moco binding site; other site 324602006577 metal coordination site [ion binding]; other site 324602006578 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 324602006579 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602006580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602006581 active site 324602006582 phosphorylation site [posttranslational modification] 324602006583 intermolecular recognition site; other site 324602006584 dimerization interface [polypeptide binding]; other site 324602006585 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324602006586 DNA binding site [nucleotide binding] 324602006587 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 324602006588 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 324602006589 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 324602006590 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 324602006591 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 324602006592 catalytic triad [active] 324602006593 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 324602006594 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 324602006595 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 324602006596 active site 324602006597 substrate binding site [chemical binding]; other site 324602006598 cosubstrate binding site; other site 324602006599 catalytic site [active] 324602006600 oxidative damage protection protein; Provisional; Region: PRK05408 324602006601 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 324602006602 B12 binding domain; Region: B12-binding; pfam02310 324602006603 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324602006604 FeS/SAM binding site; other site 324602006605 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 324602006606 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 324602006607 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 324602006608 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 324602006609 Uncharacterized conserved protein [Function unknown]; Region: COG2308 324602006610 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 324602006611 Di-iron ligands [ion binding]; other site 324602006612 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 324602006613 C-terminal peptidase (prc); Region: prc; TIGR00225 324602006614 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 324602006615 protein binding site [polypeptide binding]; other site 324602006616 Catalytic dyad [active] 324602006617 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 324602006618 oligomer interface [polypeptide binding]; other site 324602006619 active site 324602006620 metal binding site [ion binding]; metal-binding site 324602006621 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 324602006622 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 324602006623 active site 324602006624 NTP binding site [chemical binding]; other site 324602006625 metal binding triad [ion binding]; metal-binding site 324602006626 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 324602006627 Lamin Tail Domain; Region: LTD; pfam00932 324602006628 CAAX protease self-immunity; Region: Abi; pfam02517 324602006629 beta-phosphoglucomutase; Region: bPGM; TIGR01990 324602006630 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 324602006631 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324602006632 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 324602006633 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 324602006634 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 324602006635 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324602006636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602006637 dimer interface [polypeptide binding]; other site 324602006638 conserved gate region; other site 324602006639 putative PBP binding loops; other site 324602006640 ABC-ATPase subunit interface; other site 324602006641 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324602006642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602006643 dimer interface [polypeptide binding]; other site 324602006644 conserved gate region; other site 324602006645 putative PBP binding loops; other site 324602006646 ABC-ATPase subunit interface; other site 324602006647 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324602006648 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324602006649 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324602006650 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324602006651 DNA binding site [nucleotide binding] 324602006652 domain linker motif; other site 324602006653 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 324602006654 ligand binding site [chemical binding]; other site 324602006655 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 324602006656 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 324602006657 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 324602006658 active site 324602006659 HIGH motif; other site 324602006660 KMSK motif region; other site 324602006661 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 324602006662 tRNA binding surface [nucleotide binding]; other site 324602006663 anticodon binding site; other site 324602006664 Protein of unknown function DUF262; Region: DUF262; pfam03235 324602006665 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 324602006666 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 324602006667 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324602006668 active site 324602006669 motif I; other site 324602006670 motif II; other site 324602006671 Fic family protein [Function unknown]; Region: COG3177 324602006672 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 324602006673 Fic/DOC family; Region: Fic; pfam02661 324602006674 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 324602006675 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 324602006676 putative active site [active] 324602006677 putative metal binding site [ion binding]; other site 324602006678 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 324602006679 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 324602006680 GIY-YIG motif/motif A; other site 324602006681 active site 324602006682 catalytic site [active] 324602006683 putative DNA binding site [nucleotide binding]; other site 324602006684 metal binding site [ion binding]; metal-binding site 324602006685 UvrB/uvrC motif; Region: UVR; pfam02151 324602006686 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 324602006687 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 324602006688 DNA binding site [nucleotide binding] 324602006689 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 324602006690 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 324602006691 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 324602006692 Protein of unknown function DUF58; Region: DUF58; pfam01882 324602006693 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 324602006694 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 324602006695 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 324602006696 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324602006697 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 324602006698 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324602006699 DNA binding residues [nucleotide binding] 324602006700 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 324602006701 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 324602006702 Ligand Binding Site [chemical binding]; other site 324602006703 TilS substrate binding domain; Region: TilS; pfam09179 324602006704 TilS substrate C-terminal domain; Region: TilS_C; smart00977 324602006705 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324602006706 active site 324602006707 FtsH Extracellular; Region: FtsH_ext; pfam06480 324602006708 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 324602006709 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602006710 Walker A motif; other site 324602006711 ATP binding site [chemical binding]; other site 324602006712 Walker B motif; other site 324602006713 arginine finger; other site 324602006714 Peptidase family M41; Region: Peptidase_M41; pfam01434 324602006715 Acyltransferase family; Region: Acyl_transf_3; cl19154 324602006716 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 324602006717 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 324602006718 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 324602006719 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 324602006720 ATP-binding site [chemical binding]; other site 324602006721 CoA-binding site [chemical binding]; other site 324602006722 Mg2+-binding site [ion binding]; other site 324602006723 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 324602006724 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 324602006725 acyl-activating enzyme (AAE) consensus motif; other site 324602006726 putative AMP binding site [chemical binding]; other site 324602006727 putative active site [active] 324602006728 putative CoA binding site [chemical binding]; other site 324602006729 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 324602006730 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 324602006731 16S/18S rRNA binding site [nucleotide binding]; other site 324602006732 S13e-L30e interaction site [polypeptide binding]; other site 324602006733 25S rRNA binding site [nucleotide binding]; other site 324602006734 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 324602006735 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 324602006736 RNase E interface [polypeptide binding]; other site 324602006737 trimer interface [polypeptide binding]; other site 324602006738 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 324602006739 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 324602006740 RNase E interface [polypeptide binding]; other site 324602006741 trimer interface [polypeptide binding]; other site 324602006742 active site 324602006743 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 324602006744 putative nucleic acid binding region [nucleotide binding]; other site 324602006745 G-X-X-G motif; other site 324602006746 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 324602006747 RNA binding site [nucleotide binding]; other site 324602006748 domain interface; other site 324602006749 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324602006750 Putative lysophospholipase; Region: Hydrolase_4; cl19140 324602006751 DEAD-like helicases superfamily; Region: DEXDc; smart00487 324602006752 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324602006753 ATP binding site [chemical binding]; other site 324602006754 putative Mg++ binding site [ion binding]; other site 324602006755 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324602006756 nucleotide binding region [chemical binding]; other site 324602006757 ATP-binding site [chemical binding]; other site 324602006758 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 324602006759 signal recognition particle protein; Provisional; Region: PRK10867 324602006760 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 324602006761 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 324602006762 P loop; other site 324602006763 GTP binding site [chemical binding]; other site 324602006764 Signal peptide binding domain; Region: SRP_SPB; pfam02978 324602006765 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 324602006766 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cd02409 324602006767 G-X-X-G motif; other site 324602006768 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 324602006769 RimM N-terminal domain; Region: RimM; pfam01782 324602006770 PRC-barrel domain; Region: PRC; pfam05239 324602006771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602006772 active site 324602006773 phosphorylation site [posttranslational modification] 324602006774 intermolecular recognition site; other site 324602006775 dimerization interface [polypeptide binding]; other site 324602006776 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 324602006777 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 324602006778 PAS domain; Region: PAS; smart00091 324602006779 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602006780 dimer interface [polypeptide binding]; other site 324602006781 phosphorylation site [posttranslational modification] 324602006782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602006783 ATP binding site [chemical binding]; other site 324602006784 Mg2+ binding site [ion binding]; other site 324602006785 G-X-G motif; other site 324602006786 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 324602006787 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 324602006788 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 324602006789 metal binding site [ion binding]; metal-binding site 324602006790 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 324602006791 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 324602006792 purine monophosphate binding site [chemical binding]; other site 324602006793 dimer interface [polypeptide binding]; other site 324602006794 putative catalytic residues [active] 324602006795 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 324602006796 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 324602006797 Transcriptional regulators [Transcription]; Region: MarR; COG1846 324602006798 MarR family; Region: MarR_2; cl17246 324602006799 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 324602006800 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 324602006801 G1 box; other site 324602006802 GTP/Mg2+ binding site [chemical binding]; other site 324602006803 G2 box; other site 324602006804 Switch I region; other site 324602006805 G3 box; other site 324602006806 Switch II region; other site 324602006807 G4 box; other site 324602006808 G5 box; other site 324602006809 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 324602006810 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 324602006811 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 324602006812 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 324602006813 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 324602006814 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602006815 putative active site [active] 324602006816 heme pocket [chemical binding]; other site 324602006817 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602006818 dimer interface [polypeptide binding]; other site 324602006819 phosphorylation site [posttranslational modification] 324602006820 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602006821 ATP binding site [chemical binding]; other site 324602006822 Mg2+ binding site [ion binding]; other site 324602006823 G-X-G motif; other site 324602006824 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 324602006825 Domain of unknown function DUF11; Region: DUF11; cl17728 324602006826 Protein of unknown function DUF58; Region: DUF58; pfam01882 324602006827 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 324602006828 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 324602006829 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324602006830 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 324602006831 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 324602006832 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324602006833 motif II; other site 324602006834 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602006835 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602006836 active site 324602006837 phosphorylation site [posttranslational modification] 324602006838 intermolecular recognition site; other site 324602006839 dimerization interface [polypeptide binding]; other site 324602006840 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 324602006841 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 324602006842 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 324602006843 NAD(P) binding site [chemical binding]; other site 324602006844 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 324602006845 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 324602006846 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324602006847 Coenzyme A binding pocket [chemical binding]; other site 324602006848 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 324602006849 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 324602006850 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 324602006851 chaperone protein DnaJ; Provisional; Region: PRK10767 324602006852 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 324602006853 HSP70 interaction site [polypeptide binding]; other site 324602006854 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 324602006855 substrate binding site [polypeptide binding]; other site 324602006856 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 324602006857 Zn binding sites [ion binding]; other site 324602006858 dimer interface [polypeptide binding]; other site 324602006859 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 324602006860 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 324602006861 nucleotide binding site [chemical binding]; other site 324602006862 NEF interaction site [polypeptide binding]; other site 324602006863 SBD interface [polypeptide binding]; other site 324602006864 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 324602006865 dimer interface [polypeptide binding]; other site 324602006866 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 324602006867 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 324602006868 HrcA protein C terminal domain; Region: HrcA; pfam01628 324602006869 Beta-propeller repeat; Region: SBBP; pfam06739 324602006870 Beta-propeller repeat; Region: SBBP; pfam06739 324602006871 Beta-propeller repeat; Region: SBBP; pfam06739 324602006872 Beta-propeller repeat; Region: SBBP; pfam06739 324602006873 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 324602006874 Beta-propeller repeat; Region: SBBP; pfam06739 324602006875 Beta-propeller repeat; Region: SBBP; pfam06739 324602006876 Beta-propeller repeat; Region: SBBP; pfam06739 324602006877 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 324602006878 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 324602006879 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 324602006880 dimer interface [polypeptide binding]; other site 324602006881 PYR/PP interface [polypeptide binding]; other site 324602006882 TPP binding site [chemical binding]; other site 324602006883 substrate binding site [chemical binding]; other site 324602006884 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 324602006885 Domain of unknown function; Region: EKR; pfam10371 324602006886 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 324602006887 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 324602006888 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 324602006889 TPP-binding site [chemical binding]; other site 324602006890 dimer interface [polypeptide binding]; other site 324602006891 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 324602006892 putative active site [active] 324602006893 putative FMN binding site [chemical binding]; other site 324602006894 putative substrate binding site [chemical binding]; other site 324602006895 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324602006896 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324602006897 MFS/sugar transport protein; Region: MFS_2; pfam13347 324602006898 putative symporter YagG; Provisional; Region: PRK09669; cl15392 324602006899 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 324602006900 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324602006901 catalytic residue [active] 324602006902 short chain dehydrogenase; Provisional; Region: PRK08263 324602006903 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 324602006904 NADP binding site [chemical binding]; other site 324602006905 active site 324602006906 steroid binding site; other site 324602006907 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 324602006908 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 324602006909 PYR/PP interface [polypeptide binding]; other site 324602006910 dimer interface [polypeptide binding]; other site 324602006911 TPP binding site [chemical binding]; other site 324602006912 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 324602006913 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 324602006914 TPP-binding site; other site 324602006915 dimer interface [polypeptide binding]; other site 324602006916 hypothetical protein; Provisional; Region: PRK08201 324602006917 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 324602006918 metal binding site [ion binding]; metal-binding site 324602006919 putative dimer interface [polypeptide binding]; other site 324602006920 geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023 324602006921 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 324602006922 Bacteriochlorophyll/chlorophyll synthetase; Region: PT_UbiA_chlorophyll; cd13958 324602006923 putative active site [active] 324602006924 Cytochrome C subunit of the bacterial photosynthetic reaction center; Region: CytoC_RC; cd09224 324602006925 subunit interface [polypeptide binding]; other site 324602006926 Heme binding sites [chemical binding]; other site 324602006927 Antenna complex alpha/beta subunit; Region: LHC; pfam00556 324602006928 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324602006929 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324602006930 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324602006931 Walker A/P-loop; other site 324602006932 ATP binding site [chemical binding]; other site 324602006933 Q-loop/lid; other site 324602006934 ABC transporter signature motif; other site 324602006935 Walker B; other site 324602006936 D-loop; other site 324602006937 H-loop/switch region; other site 324602006938 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324602006939 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324602006940 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 324602006941 Walker A/P-loop; other site 324602006942 ATP binding site [chemical binding]; other site 324602006943 Q-loop/lid; other site 324602006944 ABC transporter signature motif; other site 324602006945 Walker B; other site 324602006946 D-loop; other site 324602006947 H-loop/switch region; other site 324602006948 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602006949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602006950 active site 324602006951 phosphorylation site [posttranslational modification] 324602006952 intermolecular recognition site; other site 324602006953 dimerization interface [polypeptide binding]; other site 324602006954 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324602006955 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602006956 dimer interface [polypeptide binding]; other site 324602006957 phosphorylation site [posttranslational modification] 324602006958 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602006959 ATP binding site [chemical binding]; other site 324602006960 Mg2+ binding site [ion binding]; other site 324602006961 G-X-G motif; other site 324602006962 Cache domain; Region: Cache_1; pfam02743 324602006963 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 324602006964 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324602006965 dimerization interface [polypeptide binding]; other site 324602006966 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 324602006967 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324602006968 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602006969 dimer interface [polypeptide binding]; other site 324602006970 phosphorylation site [posttranslational modification] 324602006971 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602006972 ATP binding site [chemical binding]; other site 324602006973 Mg2+ binding site [ion binding]; other site 324602006974 G-X-G motif; other site 324602006975 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 324602006976 amidase catalytic site [active] 324602006977 Zn binding residues [ion binding]; other site 324602006978 substrate binding site [chemical binding]; other site 324602006979 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 324602006980 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; cl08459 324602006981 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 324602006982 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 324602006983 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 324602006984 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 324602006985 Protein of unknown function DUF86; Region: DUF86; cl01031 324602006986 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 324602006987 active site 324602006988 NTP binding site [chemical binding]; other site 324602006989 metal binding triad [ion binding]; metal-binding site 324602006990 antibiotic binding site [chemical binding]; other site 324602006991 Protein of unknown function DUF86; Region: DUF86; cl01031 324602006992 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 324602006993 active site 324602006994 NTP binding site [chemical binding]; other site 324602006995 metal binding triad [ion binding]; metal-binding site 324602006996 antibiotic binding site [chemical binding]; other site 324602006997 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 324602006998 active site 324602006999 dimer interface [polypeptide binding]; other site 324602007000 metal binding site [ion binding]; metal-binding site 324602007001 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 324602007002 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 324602007003 dimer interface [polypeptide binding]; other site 324602007004 putative functional site; other site 324602007005 putative MPT binding site; other site 324602007006 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 324602007007 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 324602007008 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 324602007009 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 324602007010 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 324602007011 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 324602007012 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 324602007013 Walker A/P-loop; other site 324602007014 ATP binding site [chemical binding]; other site 324602007015 Q-loop/lid; other site 324602007016 ABC transporter signature motif; other site 324602007017 Walker B; other site 324602007018 D-loop; other site 324602007019 H-loop/switch region; other site 324602007020 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 324602007021 putative carbohydrate binding site [chemical binding]; other site 324602007022 VanZ like family; Region: VanZ; cl01971 324602007023 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 324602007024 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 324602007025 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 324602007026 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 324602007027 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 324602007028 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 324602007029 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 324602007030 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 324602007031 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 324602007032 active site 324602007033 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 324602007034 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 324602007035 NodB motif; other site 324602007036 active site 324602007037 catalytic site [active] 324602007038 metal binding site [ion binding]; metal-binding site 324602007039 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537 324602007040 ATP-sulfurylase; Region: ATPS; cd00517 324602007041 active site 324602007042 HXXH motif; other site 324602007043 flexible loop; other site 324602007044 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 324602007045 ligand-binding site [chemical binding]; other site 324602007046 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 324602007047 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 324602007048 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 324602007049 trimer interface [polypeptide binding]; other site 324602007050 active site 324602007051 substrate binding site [chemical binding]; other site 324602007052 CoA binding site [chemical binding]; other site 324602007053 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 324602007054 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 324602007055 active site 324602007056 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602007057 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 324602007058 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 324602007059 Chain length determinant protein; Region: Wzz; pfam02706 324602007060 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 324602007061 AAA domain; Region: AAA_31; pfam13614 324602007062 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 324602007063 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 324602007064 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 324602007065 HlyD family secretion protein; Region: HlyD_3; pfam13437 324602007066 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324602007067 extended (e) SDRs; Region: SDR_e; cd08946 324602007068 NAD(P) binding site [chemical binding]; other site 324602007069 active site 324602007070 substrate binding site [chemical binding]; other site 324602007071 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 324602007072 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 324602007073 NADP binding site [chemical binding]; other site 324602007074 active site 324602007075 putative substrate binding site [chemical binding]; other site 324602007076 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 324602007077 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 324602007078 metal-binding site 324602007079 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 324602007080 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 324602007081 active site 324602007082 putative glycosyl transferase; Provisional; Region: PRK10063 324602007083 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 324602007084 metal-binding site 324602007085 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324602007086 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602007087 YdjC-like protein; Region: YdjC; pfam04794 324602007088 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 324602007089 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 324602007090 AMP binding site [chemical binding]; other site 324602007091 active site 324602007092 acyl-activating enzyme (AAE) consensus motif; other site 324602007093 CoA binding site [chemical binding]; other site 324602007094 putative glycosyl transferase; Provisional; Region: PRK10307 324602007095 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 324602007096 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602007097 PAS domain; Region: PAS_9; pfam13426 324602007098 putative active site [active] 324602007099 heme pocket [chemical binding]; other site 324602007100 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602007101 PAS fold; Region: PAS_3; pfam08447 324602007102 putative active site [active] 324602007103 heme pocket [chemical binding]; other site 324602007104 GAF domain; Region: GAF_2; pfam13185 324602007105 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602007106 PAS fold; Region: PAS_3; pfam08447 324602007107 putative active site [active] 324602007108 heme pocket [chemical binding]; other site 324602007109 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602007110 dimer interface [polypeptide binding]; other site 324602007111 phosphorylation site [posttranslational modification] 324602007112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602007113 ATP binding site [chemical binding]; other site 324602007114 Mg2+ binding site [ion binding]; other site 324602007115 G-X-G motif; other site 324602007116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602007117 active site 324602007118 phosphorylation site [posttranslational modification] 324602007119 intermolecular recognition site; other site 324602007120 dimerization interface [polypeptide binding]; other site 324602007121 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 324602007122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602007123 S-adenosylmethionine binding site [chemical binding]; other site 324602007124 FAD binding domain; Region: FAD_binding_4; pfam01565 324602007125 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 324602007126 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 324602007127 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 324602007128 FAD binding domain; Region: FAD_binding_4; pfam01565 324602007129 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 324602007130 FAD binding domain; Region: FAD_binding_4; pfam01565 324602007131 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 324602007132 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 324602007133 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 324602007134 FAD binding domain; Region: FAD_binding_4; pfam01565 324602007135 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 324602007136 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 324602007137 Cysteine-rich domain; Region: CCG; pfam02754 324602007138 Cysteine-rich domain; Region: CCG; pfam02754 324602007139 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 324602007140 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 324602007141 molybdopterin cofactor binding site; other site 324602007142 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 324602007143 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 324602007144 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 324602007145 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 324602007146 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 324602007147 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 324602007148 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 324602007149 heme-binding residues [chemical binding]; other site 324602007150 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 324602007151 Cu(I) binding site [ion binding]; other site 324602007152 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 324602007153 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 324602007154 Uncharacterized subfamily with similarity to Heme-copper oxidase subunit II cupredoxin domain; Region: CuRO_HCO_II_like_2; cd13915 324602007155 CuA binuclear center [ion binding]; other site 324602007156 Cytochrome c; Region: Cytochrom_C; cl11414 324602007157 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 324602007158 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 324602007159 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 324602007160 Subunit I/III interface [polypeptide binding]; other site 324602007161 caa(3)-type oxidase, subunit IV; Region: caa3_sub_IV; TIGR02229 324602007162 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 324602007163 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 324602007164 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324602007165 motif II; other site 324602007166 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 324602007167 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324602007168 Coenzyme A binding pocket [chemical binding]; other site 324602007169 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324602007170 Coenzyme A binding pocket [chemical binding]; other site 324602007171 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 324602007172 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324602007173 Coenzyme A binding pocket [chemical binding]; other site 324602007174 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324602007175 Coenzyme A binding pocket [chemical binding]; other site 324602007176 beta subunit of N-acylethanolamine-hydrolyzing acid amidase; Region: NAAA-beta; pfam15508 324602007177 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 324602007178 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 324602007179 active site 324602007180 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 324602007181 active site 324602007182 metal binding site [ion binding]; metal-binding site 324602007183 homotetramer interface [polypeptide binding]; other site 324602007184 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 324602007185 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 324602007186 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324602007187 non-specific DNA binding site [nucleotide binding]; other site 324602007188 salt bridge; other site 324602007189 sequence-specific DNA binding site [nucleotide binding]; other site 324602007190 Cupin domain; Region: Cupin_2; pfam07883 324602007191 AP2 domain; Region: AP2; pfam00847 324602007192 Putative lysophospholipase; Region: Hydrolase_4; cl19140 324602007193 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 324602007194 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 324602007195 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 324602007196 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 324602007197 large tegument protein UL36; Provisional; Region: PHA03247 324602007198 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 324602007199 26S proteasome subunit P45 family; Region: 26Sp45; TIGR01242 324602007200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602007201 Walker A motif; other site 324602007202 ATP binding site [chemical binding]; other site 324602007203 Walker B motif; other site 324602007204 arginine finger; other site 324602007205 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 324602007206 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 324602007207 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 324602007208 Nucleolar protein 12 (25kDa); Region: Nop25; pfam09805 324602007209 Phage-related protein [Function unknown]; Region: COG5412 324602007210 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 324602007211 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 324602007212 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 324602007213 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 324602007214 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 324602007215 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 324602007216 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 324602007217 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 324602007218 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 324602007219 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 324602007220 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 324602007221 active site 324602007222 nucleotide binding site [chemical binding]; other site 324602007223 HIGH motif; other site 324602007224 KMSKS motif; other site 324602007225 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 324602007226 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 324602007227 glucose-6-phosphate isomerase; Provisional; Region: PRK00973 324602007228 active site 324602007229 dimer interface [polypeptide binding]; other site 324602007230 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 324602007231 dimer interface [polypeptide binding]; other site 324602007232 active site 324602007233 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 324602007234 elongation factor Tu; Reviewed; Region: PRK00049 324602007235 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 324602007236 G1 box; other site 324602007237 GEF interaction site [polypeptide binding]; other site 324602007238 GTP/Mg2+ binding site [chemical binding]; other site 324602007239 Switch I region; other site 324602007240 G2 box; other site 324602007241 G3 box; other site 324602007242 Switch II region; other site 324602007243 G4 box; other site 324602007244 G5 box; other site 324602007245 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 324602007246 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 324602007247 Antibiotic Binding Site [chemical binding]; other site 324602007248 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 324602007249 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 324602007250 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 324602007251 putative homodimer interface [polypeptide binding]; other site 324602007252 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 324602007253 heterodimer interface [polypeptide binding]; other site 324602007254 homodimer interface [polypeptide binding]; other site 324602007255 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 324602007256 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 324602007257 23S rRNA interface [nucleotide binding]; other site 324602007258 L7/L12 interface [polypeptide binding]; other site 324602007259 putative thiostrepton binding site; other site 324602007260 L25 interface [polypeptide binding]; other site 324602007261 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 324602007262 mRNA/rRNA interface [nucleotide binding]; other site 324602007263 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 324602007264 23S rRNA interface [nucleotide binding]; other site 324602007265 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 324602007266 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 324602007267 peripheral dimer interface [polypeptide binding]; other site 324602007268 core dimer interface [polypeptide binding]; other site 324602007269 L10 interface [polypeptide binding]; other site 324602007270 L11 interface [polypeptide binding]; other site 324602007271 putative EF-Tu interaction site [polypeptide binding]; other site 324602007272 putative EF-G interaction site [polypeptide binding]; other site 324602007273 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 324602007274 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 324602007275 active site 324602007276 catalytic motif [active] 324602007277 Zn binding site [ion binding]; other site 324602007278 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 324602007279 Domain of unknown function DUF21; Region: DUF21; pfam01595 324602007280 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 324602007281 Transporter associated domain; Region: CorC_HlyC; pfam03471 324602007282 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 324602007283 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 324602007284 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324602007285 active site 324602007286 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 324602007287 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 324602007288 ABC transporter; Region: ABC_tran_2; pfam12848 324602007289 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 324602007290 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 324602007291 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 324602007292 catalytic motif [active] 324602007293 Zn binding site [ion binding]; other site 324602007294 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 324602007295 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 324602007296 Lumazine binding domain; Region: Lum_binding; pfam00677 324602007297 Lumazine binding domain; Region: Lum_binding; pfam00677 324602007298 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 324602007299 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 324602007300 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 324602007301 dimerization interface [polypeptide binding]; other site 324602007302 active site 324602007303 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 324602007304 homopentamer interface [polypeptide binding]; other site 324602007305 active site 324602007306 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 324602007307 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 324602007308 putative NAD(P) binding site [chemical binding]; other site 324602007309 putative active site [active] 324602007310 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 324602007311 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 324602007312 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 324602007313 protein binding site [polypeptide binding]; other site 324602007314 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 324602007315 putative active site [active] 324602007316 putative CoA binding site [chemical binding]; other site 324602007317 nudix motif; other site 324602007318 metal binding site [ion binding]; metal-binding site 324602007319 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 324602007320 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 324602007321 inhibitor-cofactor binding pocket; inhibition site 324602007322 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602007323 catalytic residue [active] 324602007324 Pantoate-beta-alanine ligase; Region: PanC; cd00560 324602007325 active site 324602007326 ATP-binding site [chemical binding]; other site 324602007327 pantoate-binding site; other site 324602007328 HXXH motif; other site 324602007329 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 324602007330 oligomerization interface [polypeptide binding]; other site 324602007331 active site 324602007332 metal binding site [ion binding]; metal-binding site 324602007333 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324602007334 Putative lysophospholipase; Region: Hydrolase_4; cl19140 324602007335 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl19094 324602007336 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 324602007337 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 324602007338 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 324602007339 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 324602007340 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 324602007341 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 324602007342 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 324602007343 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 324602007344 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 324602007345 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 324602007346 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 324602007347 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 324602007348 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 324602007349 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 324602007350 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 324602007351 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 324602007352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602007353 H+ Antiporter protein; Region: 2A0121; TIGR00900 324602007354 putative substrate translocation pore; other site 324602007355 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324602007356 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324602007357 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 324602007358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602007359 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324602007360 putative substrate translocation pore; other site 324602007361 chaperone protein HscA; Provisional; Region: hscA; PRK05183 324602007362 GAF domain; Region: GAF_2; pfam13185 324602007363 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 324602007364 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 324602007365 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 324602007366 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602007367 S-adenosylmethionine binding site [chemical binding]; other site 324602007368 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 324602007369 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602007370 active site 324602007371 phosphorylation site [posttranslational modification] 324602007372 intermolecular recognition site; other site 324602007373 dimerization interface [polypeptide binding]; other site 324602007374 ANTAR domain; Region: ANTAR; pfam03861 324602007375 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 324602007376 homotrimer interaction site [polypeptide binding]; other site 324602007377 active site 324602007378 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 324602007379 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 324602007380 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 324602007381 active site 324602007382 multimer interface [polypeptide binding]; other site 324602007383 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 324602007384 predicted active site [active] 324602007385 catalytic triad [active] 324602007386 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324602007387 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602007388 Walker A motif; other site 324602007389 Walker A/P-loop; other site 324602007390 ATP binding site [chemical binding]; other site 324602007391 ATP binding site [chemical binding]; other site 324602007392 Walker B motif; other site 324602007393 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 324602007394 RxxxH motif; other site 324602007395 thymidylate kinase; Validated; Region: tmk; PRK00698 324602007396 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 324602007397 TMP-binding site; other site 324602007398 ATP-binding site [chemical binding]; other site 324602007399 Protein of unknown function (DUF970); Region: DUF970; cl17525 324602007400 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 324602007401 Double zinc ribbon; Region: DZR; pfam12773 324602007402 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 324602007403 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 324602007404 putative active site pocket [active] 324602007405 cleavage site 324602007406 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 324602007407 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 324602007408 peptide binding site [polypeptide binding]; other site 324602007409 dimer interface [polypeptide binding]; other site 324602007410 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 324602007411 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 324602007412 Hydrogenase expression/synthesis hypA family; Region: HypA; cl19201 324602007413 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 324602007414 Amidase; Region: Amidase; cl11426 324602007415 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 324602007416 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 324602007417 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 324602007418 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 324602007419 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 324602007420 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 324602007421 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 324602007422 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 324602007423 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 324602007424 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 324602007425 putative active site [active] 324602007426 putative metal binding site [ion binding]; other site 324602007427 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 324602007428 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324602007429 Walker A/P-loop; other site 324602007430 ATP binding site [chemical binding]; other site 324602007431 Q-loop/lid; other site 324602007432 Orbivirus non-structural protein NS1, or hydrophobic tubular protein; Region: Orbi_NS1; pfam01718 324602007433 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324602007434 ABC transporter signature motif; other site 324602007435 Walker B; other site 324602007436 D-loop; other site 324602007437 H-loop/switch region; other site 324602007438 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 324602007439 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324602007440 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324602007441 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324602007442 dimerization interface [polypeptide binding]; other site 324602007443 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 324602007444 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 324602007445 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 324602007446 nucleotide binding site [chemical binding]; other site 324602007447 NEF interaction site [polypeptide binding]; other site 324602007448 SBD interface [polypeptide binding]; other site 324602007449 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 324602007450 cyclase homology domain; Region: CHD; cd07302 324602007451 nucleotidyl binding site; other site 324602007452 metal binding site [ion binding]; metal-binding site 324602007453 dimer interface [polypeptide binding]; other site 324602007454 cyclase homology domain; Region: CHD; cd07302 324602007455 nucleotidyl binding site; other site 324602007456 metal binding site [ion binding]; metal-binding site 324602007457 dimer interface [polypeptide binding]; other site 324602007458 Predicted ATPase [General function prediction only]; Region: COG3899 324602007459 AAA ATPase domain; Region: AAA_16; pfam13191 324602007460 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602007461 TPR motif; other site 324602007462 binding surface 324602007463 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 324602007464 putative active site [active] 324602007465 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 324602007466 cyclase homology domain; Region: CHD; cd07302 324602007467 nucleotidyl binding site; other site 324602007468 metal binding site [ion binding]; metal-binding site 324602007469 dimer interface [polypeptide binding]; other site 324602007470 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602007471 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 324602007472 Protein of unknown function (DUF970); Region: DUF970; cl17525 324602007473 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324602007474 active site 324602007475 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 324602007476 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 324602007477 AAA ATPase domain; Region: AAA_16; pfam13191 324602007478 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 324602007479 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602007480 binding surface 324602007481 TPR motif; other site 324602007482 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 324602007483 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 324602007484 Walker A/P-loop; other site 324602007485 ATP binding site [chemical binding]; other site 324602007486 Q-loop/lid; other site 324602007487 ABC transporter signature motif; other site 324602007488 Walker B; other site 324602007489 D-loop; other site 324602007490 H-loop/switch region; other site 324602007491 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 324602007492 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 324602007493 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 324602007494 Walker A/P-loop; other site 324602007495 ATP binding site [chemical binding]; other site 324602007496 Q-loop/lid; other site 324602007497 ABC transporter signature motif; other site 324602007498 Walker B; other site 324602007499 D-loop; other site 324602007500 H-loop/switch region; other site 324602007501 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 324602007502 N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This...; Region: CSHase; cd01015 324602007503 catalytic triad [active] 324602007504 substrate binding site [chemical binding]; other site 324602007505 domain interfaces; other site 324602007506 conserved cis-peptide bond; other site 324602007507 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; cl19816 324602007508 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 324602007509 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 324602007510 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 324602007511 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 324602007512 active site 324602007513 catalytic residues [active] 324602007514 metal binding site [ion binding]; metal-binding site 324602007515 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 324602007516 Transcriptional regulators [Transcription]; Region: GntR; COG1802 324602007517 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324602007518 DNA-binding site [nucleotide binding]; DNA binding site 324602007519 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 324602007520 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 324602007521 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 324602007522 Probable Catalytic site; other site 324602007523 metal-binding site 324602007524 CRISPR/Cas system-associated protein Csx3; Region: Csx3_III-U; cl09837 324602007525 CRISPR/Cas system-associated protein Csx3; Region: Csx3_III-U; cd09740 324602007526 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09741 324602007527 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324602007528 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 324602007529 DNA binding residues [nucleotide binding] 324602007530 Domain of unknown function (DUF1887); Region: DUF1887; pfam09002 324602007531 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 324602007532 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 324602007533 CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cd09700 324602007534 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 324602007535 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 324602007536 CRISPR-associated protein, TIGR03984 family; Region: TIGR03984 324602007537 CRISPR-associated protein; Region: TIGR03986 324602007538 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 324602007539 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 324602007540 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324602007541 non-specific DNA binding site [nucleotide binding]; other site 324602007542 salt bridge; other site 324602007543 sequence-specific DNA binding site [nucleotide binding]; other site 324602007544 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 324602007545 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 324602007546 Double zinc ribbon; Region: DZR; pfam12773 324602007547 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 324602007548 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 324602007549 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 324602007550 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 324602007551 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 324602007552 putative NAD(P) binding site [chemical binding]; other site 324602007553 putative substrate binding site [chemical binding]; other site 324602007554 catalytic Zn binding site [ion binding]; other site 324602007555 structural Zn binding site [ion binding]; other site 324602007556 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 324602007557 N- and C-terminal domain interface [polypeptide binding]; other site 324602007558 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 324602007559 active site 324602007560 putative catalytic site [active] 324602007561 metal binding site [ion binding]; metal-binding site 324602007562 ATP binding site [chemical binding]; other site 324602007563 carbohydrate binding site [chemical binding]; other site 324602007564 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase; Region: RhaD_aldol-ADH; TIGR02632 324602007565 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 324602007566 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324602007567 NAD(P) binding site [chemical binding]; other site 324602007568 active site 324602007569 L-rhamnose isomerase; Provisional; Region: PRK01076 324602007570 Domain of unknown function (DUF718); Region: DUF718; pfam05336 324602007571 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 324602007572 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 324602007573 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 324602007574 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 324602007575 ligand binding site [chemical binding]; other site 324602007576 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 324602007577 TM-ABC transporter signature motif; other site 324602007578 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 324602007579 TM-ABC transporter signature motif; other site 324602007580 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 324602007581 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 324602007582 Walker A/P-loop; other site 324602007583 ATP binding site [chemical binding]; other site 324602007584 Q-loop/lid; other site 324602007585 ABC transporter signature motif; other site 324602007586 Walker B; other site 324602007587 D-loop; other site 324602007588 H-loop/switch region; other site 324602007589 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 324602007590 transcriptional repressor UlaR; Provisional; Region: PRK13509 324602007591 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 324602007592 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 324602007593 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09679 324602007594 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 324602007595 CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cd09700 324602007596 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09683 324602007597 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cl18985 324602007598 CRISPR-associated protein, TIGR03984 family; Region: TIGR03984 324602007599 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 324602007600 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 324602007601 putative active site [active] 324602007602 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09741 324602007603 Domain of unknown function (DUF1887); Region: DUF1887; pfam09002 324602007604 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 324602007605 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 324602007606 active site 324602007607 (T/H)XGH motif; other site 324602007608 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 324602007609 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602007610 S-adenosylmethionine binding site [chemical binding]; other site 324602007611 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 324602007612 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 324602007613 thymidine kinase; Provisional; Region: PRK04296 324602007614 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 324602007615 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 324602007616 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 324602007617 NAD binding site [chemical binding]; other site 324602007618 substrate binding site [chemical binding]; other site 324602007619 homodimer interface [polypeptide binding]; other site 324602007620 active site 324602007621 AIR carboxylase; Region: AIRC; pfam00731 324602007622 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 324602007623 ATP-grasp domain; Region: ATP-grasp; pfam02222 324602007624 Predicted transcriptional regulator [Transcription]; Region: COG2378 324602007625 HTH domain; Region: HTH_11; pfam08279 324602007626 WYL domain; Region: WYL; pfam13280 324602007627 Ribosomal protein L31; Region: Ribosomal_L31; pfam01197 324602007628 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 324602007629 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 324602007630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602007631 active site 324602007632 phosphorylation site [posttranslational modification] 324602007633 intermolecular recognition site; other site 324602007634 dimerization interface [polypeptide binding]; other site 324602007635 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 324602007636 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 324602007637 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 324602007638 dimer interface [polypeptide binding]; other site 324602007639 anticodon binding site; other site 324602007640 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 324602007641 homodimer interface [polypeptide binding]; other site 324602007642 motif 1; other site 324602007643 active site 324602007644 motif 2; other site 324602007645 GAD domain; Region: GAD; pfam02938 324602007646 motif 3; other site 324602007647 Trans-Isoprenyl Diphosphate Synthases; Region: Trans_IPPS; cd00867 324602007648 substrate binding pocket [chemical binding]; other site 324602007649 substrate-Mg2+ binding site; other site 324602007650 aspartate-rich region 1; other site 324602007651 aspartate-rich region 2; other site 324602007652 Penicillin amidase; Region: Penicil_amidase; pfam01804 324602007653 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 324602007654 active site 324602007655 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 324602007656 metal binding triad [ion binding]; metal-binding site 324602007657 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 324602007658 metal binding triad [ion binding]; metal-binding site 324602007659 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 324602007660 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 324602007661 metal binding triad [ion binding]; metal-binding site 324602007662 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 324602007663 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 324602007664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602007665 active site 324602007666 phosphorylation site [posttranslational modification] 324602007667 intermolecular recognition site; other site 324602007668 dimerization interface [polypeptide binding]; other site 324602007669 Predicted permeases [General function prediction only]; Region: COG0679 324602007670 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 324602007671 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 324602007672 DctM-like transporters; Region: DctM; pfam06808 324602007673 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 324602007674 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 324602007675 active site 324602007676 substrate-binding site [chemical binding]; other site 324602007677 metal-binding site [ion binding] 324602007678 GTP binding site [chemical binding]; other site 324602007679 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 324602007680 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 324602007681 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 324602007682 peptide binding site [polypeptide binding]; other site 324602007683 dimer interface [polypeptide binding]; other site 324602007684 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 324602007685 FAD binding pocket [chemical binding]; other site 324602007686 FAD binding motif [chemical binding]; other site 324602007687 phosphate binding motif [ion binding]; other site 324602007688 beta-alpha-beta structure motif; other site 324602007689 NAD binding pocket [chemical binding]; other site 324602007690 Iron coordination center [ion binding]; other site 324602007691 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 324602007692 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 324602007693 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 324602007694 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 324602007695 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 324602007696 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 324602007697 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 324602007698 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 324602007699 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 324602007700 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 324602007701 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 324602007702 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 324602007703 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 324602007704 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 324602007705 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 324602007706 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 324602007707 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 324602007708 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 324602007709 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 324602007710 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 324602007711 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 324602007712 phosphate binding site [ion binding]; other site 324602007713 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 324602007714 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 324602007715 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 324602007716 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 324602007717 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl19151 324602007718 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 324602007719 HEAT repeats; Region: HEAT_2; pfam13646 324602007720 HEAT repeats; Region: HEAT_2; pfam13646 324602007721 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 324602007722 protein binding surface [polypeptide binding]; other site 324602007723 HEAT repeats; Region: HEAT_2; pfam13646 324602007724 large tegument protein UL36; Provisional; Region: PHA03247 324602007725 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 324602007726 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 324602007727 nucleotide binding site [chemical binding]; other site 324602007728 Lamin Tail Domain; Region: LTD; pfam00932 324602007729 Lamin Tail Domain; Region: LTD; pfam00932 324602007730 Lamin Tail Domain; Region: LTD; pfam00932 324602007731 Lamin Tail Domain; Region: LTD; pfam00932 324602007732 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 324602007733 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 324602007734 Active_site [active] 324602007735 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 324602007736 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 324602007737 Moco binding site; other site 324602007738 metal coordination site [ion binding]; other site 324602007739 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 324602007740 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 324602007741 [2Fe-2S] cluster binding site [ion binding]; other site 324602007742 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 324602007743 putative alpha subunit interface [polypeptide binding]; other site 324602007744 putative active site [active] 324602007745 putative substrate binding site [chemical binding]; other site 324602007746 Fe binding site [ion binding]; other site 324602007747 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 324602007748 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 324602007749 homodimer interface [polypeptide binding]; other site 324602007750 active site 324602007751 TDP-binding site; other site 324602007752 acceptor substrate-binding pocket; other site 324602007753 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 324602007754 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 324602007755 active site 324602007756 ATP binding site [chemical binding]; other site 324602007757 substrate binding site [chemical binding]; other site 324602007758 activation loop (A-loop); other site 324602007759 FOG: WD40 repeat [General function prediction only]; Region: COG2319 324602007760 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 324602007761 structural tetrad; other site 324602007762 PQQ-like domain; Region: PQQ_2; pfam13360 324602007763 FOG: WD40 repeat [General function prediction only]; Region: COG2319 324602007764 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 324602007765 structural tetrad; other site 324602007766 phytoene desaturase; Region: phytoene_desat; TIGR02731 324602007767 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 324602007768 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 324602007769 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 324602007770 aspartate aminotransferase; Provisional; Region: PRK05764 324602007771 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324602007772 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602007773 homodimer interface [polypeptide binding]; other site 324602007774 catalytic residue [active] 324602007775 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 324602007776 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 324602007777 putative ribose interaction site [chemical binding]; other site 324602007778 putative ADP binding site [chemical binding]; other site 324602007779 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 324602007780 anti sigma factor interaction site; other site 324602007781 regulatory phosphorylation site [posttranslational modification]; other site 324602007782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602007783 ATP binding site [chemical binding]; other site 324602007784 Mg2+ binding site [ion binding]; other site 324602007785 G-X-G motif; other site 324602007786 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324602007787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602007788 ATP binding site [chemical binding]; other site 324602007789 Mg2+ binding site [ion binding]; other site 324602007790 G-X-G motif; other site 324602007791 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 324602007792 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 324602007793 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 324602007794 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 324602007795 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 324602007796 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 324602007797 S17 interaction site [polypeptide binding]; other site 324602007798 S8 interaction site; other site 324602007799 16S rRNA interaction site [nucleotide binding]; other site 324602007800 streptomycin interaction site [chemical binding]; other site 324602007801 23S rRNA interaction site [nucleotide binding]; other site 324602007802 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 324602007803 30S ribosomal protein S7; Validated; Region: PRK05302 324602007804 elongation factor G; Reviewed; Region: PRK00007 324602007805 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 324602007806 G1 box; other site 324602007807 putative GEF interaction site [polypeptide binding]; other site 324602007808 GTP/Mg2+ binding site [chemical binding]; other site 324602007809 Switch I region; other site 324602007810 G2 box; other site 324602007811 G3 box; other site 324602007812 Switch II region; other site 324602007813 G4 box; other site 324602007814 G5 box; other site 324602007815 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 324602007816 Elongation Factor G, domain II; Region: EFG_II; pfam14492 324602007817 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 324602007818 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 324602007819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602007820 S-adenosylmethionine binding site [chemical binding]; other site 324602007821 elongation factor Tu; Reviewed; Region: PRK00049 324602007822 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 324602007823 G1 box; other site 324602007824 GEF interaction site [polypeptide binding]; other site 324602007825 GTP/Mg2+ binding site [chemical binding]; other site 324602007826 Switch I region; other site 324602007827 G2 box; other site 324602007828 G3 box; other site 324602007829 Switch II region; other site 324602007830 G4 box; other site 324602007831 G5 box; other site 324602007832 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 324602007833 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 324602007834 Antibiotic Binding Site [chemical binding]; other site 324602007835 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 324602007836 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 324602007837 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 324602007838 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 324602007839 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 324602007840 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 324602007841 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 324602007842 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 324602007843 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 324602007844 putative translocon binding site; other site 324602007845 protein-rRNA interface [nucleotide binding]; other site 324602007846 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 324602007847 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 324602007848 G-X-X-G motif; other site 324602007849 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 324602007850 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 324602007851 23S rRNA interface [nucleotide binding]; other site 324602007852 5S rRNA interface [nucleotide binding]; other site 324602007853 putative antibiotic binding site [chemical binding]; other site 324602007854 L25 interface [polypeptide binding]; other site 324602007855 L27 interface [polypeptide binding]; other site 324602007856 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 324602007857 23S rRNA interface [nucleotide binding]; other site 324602007858 putative translocon interaction site; other site 324602007859 signal recognition particle (SRP54) interaction site; other site 324602007860 L23 interface [polypeptide binding]; other site 324602007861 trigger factor interaction site; other site 324602007862 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 324602007863 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 324602007864 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 324602007865 RNA binding site [nucleotide binding]; other site 324602007866 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 324602007867 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 324602007868 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 324602007869 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 324602007870 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 324602007871 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 324602007872 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 324602007873 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 324602007874 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 324602007875 23S rRNA interface [nucleotide binding]; other site 324602007876 L21e interface [polypeptide binding]; other site 324602007877 5S rRNA interface [nucleotide binding]; other site 324602007878 L27 interface [polypeptide binding]; other site 324602007879 L5 interface [polypeptide binding]; other site 324602007880 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 324602007881 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 324602007882 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 324602007883 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 324602007884 23S rRNA binding site [nucleotide binding]; other site 324602007885 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 324602007886 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 324602007887 SecY translocase; Region: SecY; pfam00344 324602007888 adenylate kinase; Reviewed; Region: adk; PRK00279 324602007889 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 324602007890 AMP-binding site [chemical binding]; other site 324602007891 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 324602007892 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 324602007893 rRNA binding site [nucleotide binding]; other site 324602007894 predicted 30S ribosome binding site; other site 324602007895 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 324602007896 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 324602007897 30S ribosomal protein S11; Validated; Region: PRK05309 324602007898 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 324602007899 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 324602007900 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 324602007901 RNA binding surface [nucleotide binding]; other site 324602007902 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 324602007903 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 324602007904 alphaNTD homodimer interface [polypeptide binding]; other site 324602007905 alphaNTD - beta interaction site [polypeptide binding]; other site 324602007906 alphaNTD - beta' interaction site [polypeptide binding]; other site 324602007907 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 324602007908 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 324602007909 tRNA pseudouridine synthase ACD; Provisional; Region: PRK14588 324602007910 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 324602007911 dimerization interface 3.5A [polypeptide binding]; other site 324602007912 active site 324602007913 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 324602007914 23S rRNA interface [nucleotide binding]; other site 324602007915 L3 interface [polypeptide binding]; other site 324602007916 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 324602007917 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602007918 S-adenosylmethionine binding site [chemical binding]; other site 324602007919 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 324602007920 active site 324602007921 (T/H)XGH motif; other site 324602007922 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 324602007923 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 324602007924 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 324602007925 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 324602007926 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 324602007927 dimer interface [polypeptide binding]; other site 324602007928 active site 324602007929 CoA binding pocket [chemical binding]; other site 324602007930 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 324602007931 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 324602007932 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 324602007933 NAD(P) binding site [chemical binding]; other site 324602007934 homotetramer interface [polypeptide binding]; other site 324602007935 homodimer interface [polypeptide binding]; other site 324602007936 active site 324602007937 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 324602007938 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324602007939 NAD(P) binding site [chemical binding]; other site 324602007940 active site 324602007941 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 324602007942 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 324602007943 ATP binding site [chemical binding]; other site 324602007944 Walker A motif; other site 324602007945 hexamer interface [polypeptide binding]; other site 324602007946 Walker B motif; other site 324602007947 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 324602007948 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602007949 RNA helicase; Region: RNA_helicase; pfam00910 324602007950 Walker A motif; other site 324602007951 ATP binding site [chemical binding]; other site 324602007952 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602007953 binding surface 324602007954 TPR motif; other site 324602007955 TPR repeat; Region: TPR_11; pfam13414 324602007956 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14338 324602007957 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 324602007958 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324602007959 FeS/SAM binding site; other site 324602007960 TRAM domain; Region: TRAM; pfam01938 324602007961 Class I aldolases; Region: Aldolase_Class_I; cl17187 324602007962 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 324602007963 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 324602007964 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 324602007965 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912 324602007966 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 324602007967 integral membrane protein MviN; Region: mviN; TIGR01695 324602007968 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 324602007969 phytoene desaturase; Region: crtI_fam; TIGR02734 324602007970 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 324602007971 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 324602007972 Cu(I) binding site [ion binding]; other site 324602007973 C-terminal cupredoxin domain of Ba3-like heme-copper oxidase subunit II; Region: ba3_CcO_II_C; cd13913 324602007974 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 324602007975 Subunit I/II interface [polypeptide binding]; other site 324602007976 CuA binuclear site [ion binding]; other site 324602007977 Subunit II/IIa interface [polypeptide binding]; other site 324602007978 ba3-like heme-copper oxidase subunit I. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660 324602007979 Putative D-pathway homolog; other site 324602007980 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 324602007981 Low-spin heme binding site [chemical binding]; other site 324602007982 Subunit I/II interface [polypeptide binding]; other site 324602007983 Putative Q-pathway; other site 324602007984 Putative alternate electron transfer pathway; other site 324602007985 Putative water exit pathway; other site 324602007986 Binuclear center (active site) [active] 324602007987 Putative K-pathway homolog; other site 324602007988 Putative proton exit pathway; other site 324602007989 Subunit I/IIa interface [polypeptide binding]; other site 324602007990 Electron transfer pathway; other site 324602007991 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 324602007992 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 324602007993 Walker A/P-loop; other site 324602007994 ATP binding site [chemical binding]; other site 324602007995 Q-loop/lid; other site 324602007996 ABC transporter signature motif; other site 324602007997 Walker B; other site 324602007998 D-loop; other site 324602007999 H-loop/switch region; other site 324602008000 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 324602008001 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 324602008002 putative hemin binding site; other site 324602008003 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324602008004 ABC-ATPase subunit interface; other site 324602008005 dimer interface [polypeptide binding]; other site 324602008006 putative PBP binding regions; other site 324602008007 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 324602008008 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 324602008009 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 324602008010 FeoA domain; Region: FeoA; pfam04023 324602008011 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 324602008012 putative active site [active] 324602008013 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324602008014 dimerization interface [polypeptide binding]; other site 324602008015 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602008016 dimer interface [polypeptide binding]; other site 324602008017 phosphorylation site [posttranslational modification] 324602008018 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602008019 ATP binding site [chemical binding]; other site 324602008020 Mg2+ binding site [ion binding]; other site 324602008021 G-X-G motif; other site 324602008022 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602008023 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602008024 active site 324602008025 phosphorylation site [posttranslational modification] 324602008026 intermolecular recognition site; other site 324602008027 dimerization interface [polypeptide binding]; other site 324602008028 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324602008029 DNA binding site [nucleotide binding] 324602008030 Domain of unknown function (DUF305); Region: DUF305; pfam03713 324602008031 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324602008032 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324602008033 dimerization interface [polypeptide binding]; other site 324602008034 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602008035 dimer interface [polypeptide binding]; other site 324602008036 phosphorylation site [posttranslational modification] 324602008037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602008038 ATP binding site [chemical binding]; other site 324602008039 Mg2+ binding site [ion binding]; other site 324602008040 G-X-G motif; other site 324602008041 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602008042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602008043 active site 324602008044 phosphorylation site [posttranslational modification] 324602008045 intermolecular recognition site; other site 324602008046 dimerization interface [polypeptide binding]; other site 324602008047 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324602008048 DNA binding site [nucleotide binding] 324602008049 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324602008050 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324602008051 Walker A/P-loop; other site 324602008052 ATP binding site [chemical binding]; other site 324602008053 Q-loop/lid; other site 324602008054 ABC transporter signature motif; other site 324602008055 Walker B; other site 324602008056 D-loop; other site 324602008057 H-loop/switch region; other site 324602008058 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 324602008059 RibD C-terminal domain; Region: RibD_C; cl17279 324602008060 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 324602008061 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 324602008062 putative dimer interface [polypeptide binding]; other site 324602008063 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 324602008064 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 324602008065 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 324602008066 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 324602008067 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 324602008068 SnoaL-like domain; Region: SnoaL_2; pfam12680 324602008069 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324602008070 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 324602008071 NAD(P) binding site [chemical binding]; other site 324602008072 active site 324602008073 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 324602008074 Serine hydrolase; Region: Ser_hydrolase; cl17834 324602008075 RibD C-terminal domain; Region: RibD_C; cl17279 324602008076 RibD C-terminal domain; Region: RibD_C; pfam01872 324602008077 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 324602008078 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602008079 S-adenosylmethionine binding site [chemical binding]; other site 324602008080 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 324602008081 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 324602008082 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 324602008083 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 324602008084 NADP+ binding site [chemical binding]; other site 324602008085 folate binding site [chemical binding]; other site 324602008086 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 324602008087 Protein of unknown function (DUF1109); Region: DUF1109; cl02071 324602008088 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 324602008089 O-Antigen ligase; Region: Wzy_C; pfam04932 324602008090 TIR domain; Region: TIR_2; pfam13676 324602008091 CHAT domain; Region: CHAT; cl19248 324602008092 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 324602008093 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 324602008094 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 324602008095 putative active site [active] 324602008096 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 324602008097 Methyltransferase domain; Region: Methyltransf_31; pfam13847 324602008098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602008099 S-adenosylmethionine binding site [chemical binding]; other site 324602008100 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 324602008101 Predicted membrane protein [Function unknown]; Region: COG1470 324602008102 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 324602008103 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 324602008104 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 324602008105 Walker A/P-loop; other site 324602008106 ATP binding site [chemical binding]; other site 324602008107 Q-loop/lid; other site 324602008108 ABC transporter signature motif; other site 324602008109 Walker B; other site 324602008110 D-loop; other site 324602008111 H-loop/switch region; other site 324602008112 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 324602008113 camphor resistance protein CrcB; Provisional; Region: PRK14215 324602008114 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 324602008115 FOG: CBS domain [General function prediction only]; Region: COG0517 324602008116 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 324602008117 FOG: CBS domain [General function prediction only]; Region: COG0517 324602008118 FOG: CBS domain [General function prediction only]; Region: COG0517 324602008119 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 324602008120 Clp protease ATP binding subunit; Region: clpC; CHL00095 324602008121 Clp amino terminal domain; Region: Clp_N; pfam02861 324602008122 Clp amino terminal domain; Region: Clp_N; pfam02861 324602008123 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602008124 Walker A motif; other site 324602008125 ATP binding site [chemical binding]; other site 324602008126 Walker B motif; other site 324602008127 arginine finger; other site 324602008128 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602008129 Walker A motif; other site 324602008130 ATP binding site [chemical binding]; other site 324602008131 Walker B motif; other site 324602008132 arginine finger; other site 324602008133 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 324602008134 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 324602008135 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 324602008136 RNA binding site [nucleotide binding]; other site 324602008137 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 324602008138 RNA binding site [nucleotide binding]; other site 324602008139 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 324602008140 RNA binding site [nucleotide binding]; other site 324602008141 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 324602008142 RNA binding site [nucleotide binding]; other site 324602008143 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 324602008144 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 324602008145 active site residue [active] 324602008146 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 324602008147 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 324602008148 active site 324602008149 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 324602008150 nudix motif; other site 324602008151 Domain of unknown function (DUF4491); Region: DUF4491; pfam14898 324602008152 Domain of unknown function (DUF4491); Region: DUF4491; pfam14898 324602008153 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 324602008154 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 324602008155 FMN binding site [chemical binding]; other site 324602008156 substrate binding site [chemical binding]; other site 324602008157 putative catalytic residue [active] 324602008158 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 324602008159 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 324602008160 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 324602008161 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 324602008162 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 324602008163 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 324602008164 active site 324602008165 DNA binding site [nucleotide binding] 324602008166 Int/Topo IB signature motif; other site 324602008167 glycyl-tRNA synthetase; Provisional; Region: PRK14894 324602008168 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 324602008169 dimer interface [polypeptide binding]; other site 324602008170 motif 1; other site 324602008171 active site 324602008172 motif 2; other site 324602008173 motif 3; other site 324602008174 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 324602008175 anticodon binding site; other site 324602008176 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 324602008177 Moco binding site; other site 324602008178 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 324602008179 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 324602008180 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 324602008181 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 324602008182 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 324602008183 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602008184 dimer interface [polypeptide binding]; other site 324602008185 conserved gate region; other site 324602008186 putative PBP binding loops; other site 324602008187 ABC-ATPase subunit interface; other site 324602008188 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 324602008189 haloacid dehalogenase superfamily protein; Provisional; Region: PRK14562 324602008190 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 324602008191 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 324602008192 substrate binding site [chemical binding]; other site 324602008193 activation loop (A-loop); other site 324602008194 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602008195 PAS domain; Region: PAS_9; pfam13426 324602008196 putative active site [active] 324602008197 heme pocket [chemical binding]; other site 324602008198 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 324602008199 Histidine kinase; Region: HisKA_2; pfam07568 324602008200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602008201 ATP binding site [chemical binding]; other site 324602008202 Mg2+ binding site [ion binding]; other site 324602008203 G-X-G motif; other site 324602008204 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 324602008205 tetramer interface [polypeptide binding]; other site 324602008206 dimer interface [polypeptide binding]; other site 324602008207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602008208 active site 324602008209 phosphorylation site [posttranslational modification] 324602008210 intermolecular recognition site; other site 324602008211 dimerization interface [polypeptide binding]; other site 324602008212 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602008213 PAS domain; Region: PAS_9; pfam13426 324602008214 putative active site [active] 324602008215 heme pocket [chemical binding]; other site 324602008216 GAF domain; Region: GAF_3; pfam13492 324602008217 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 324602008218 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 324602008219 catalytic residues [active] 324602008220 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 324602008221 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 324602008222 alphaNTD - beta interaction site [polypeptide binding]; other site 324602008223 alphaNTD homodimer interface [polypeptide binding]; other site 324602008224 alphaNTD - beta' interaction site [polypeptide binding]; other site 324602008225 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 324602008226 transcription termination factor Rho; Provisional; Region: PRK12608 324602008227 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 324602008228 RNA binding site [nucleotide binding]; other site 324602008229 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 324602008230 multimer interface [polypeptide binding]; other site 324602008231 Walker A motif; other site 324602008232 ATP binding site [chemical binding]; other site 324602008233 Walker B motif; other site 324602008234 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 324602008235 GTP binding site; other site 324602008236 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 324602008237 structural tetrad; other site 324602008238 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 324602008239 Methyltransferase domain; Region: Methyltransf_31; pfam13847 324602008240 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602008241 S-adenosylmethionine binding site [chemical binding]; other site 324602008242 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 324602008243 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602008244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602008245 active site 324602008246 phosphorylation site [posttranslational modification] 324602008247 intermolecular recognition site; other site 324602008248 dimerization interface [polypeptide binding]; other site 324602008249 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324602008250 DNA binding site [nucleotide binding] 324602008251 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 324602008252 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 324602008253 Walker A; other site 324602008254 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 324602008255 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 324602008256 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 324602008257 active site 324602008258 substrate binding site [chemical binding]; other site 324602008259 coenzyme B12 binding site [chemical binding]; other site 324602008260 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 324602008261 B12 binding site [chemical binding]; other site 324602008262 cobalt ligand [ion binding]; other site 324602008263 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 324602008264 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 324602008265 heterodimer interface [polypeptide binding]; other site 324602008266 substrate interaction site [chemical binding]; other site 324602008267 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 324602008268 glutamate carboxypeptidase; Reviewed; Region: PRK06133 324602008269 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 324602008270 metal binding site [ion binding]; metal-binding site 324602008271 dimer interface [polypeptide binding]; other site 324602008272 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 324602008273 active site 324602008274 ATP binding site [chemical binding]; other site 324602008275 Phosphotransferase enzyme family; Region: APH; pfam01636 324602008276 antibiotic binding site [chemical binding]; other site 324602008277 fumarylacetoacetase; Region: PLN02856 324602008278 Fumarylacetoacetase N-terminal; Region: FAA_hydrolase_N; pfam09298 324602008279 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 324602008280 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 324602008281 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 324602008282 putative active site [active] 324602008283 CAAX protease self-immunity; Region: Abi; pfam02517 324602008284 Troponin; Region: Troponin; pfam00992 324602008285 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 324602008286 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 324602008287 prephenate dehydrogenase; Validated; Region: PRK08507 324602008288 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 324602008289 Tetramer interface [polypeptide binding]; other site 324602008290 active site 324602008291 FMN-binding site [chemical binding]; other site 324602008292 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324602008293 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602008294 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 324602008295 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 324602008296 putative RNA binding site [nucleotide binding]; other site 324602008297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602008298 S-adenosylmethionine binding site [chemical binding]; other site 324602008299 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 324602008300 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 324602008301 ligand binding site; other site 324602008302 oligomer interface; other site 324602008303 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 324602008304 dimer interface [polypeptide binding]; other site 324602008305 N-terminal domain interface [polypeptide binding]; other site 324602008306 sulfate 1 binding site; other site 324602008307 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 324602008308 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 324602008309 ligand binding site; other site 324602008310 oligomer interface; other site 324602008311 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 324602008312 dimer interface [polypeptide binding]; other site 324602008313 N-terminal domain interface [polypeptide binding]; other site 324602008314 sulfate 1 binding site; other site 324602008315 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 324602008316 Restriction endonuclease NotI; Region: NotI; pfam12183 324602008317 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 324602008318 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 324602008319 Ligand Binding Site [chemical binding]; other site 324602008320 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 324602008321 Ligand Binding Site [chemical binding]; other site 324602008322 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 324602008323 MOSC domain; Region: MOSC; pfam03473 324602008324 Phosphate:Na+ Symporter (PNaS) Family; Region: 2a58; TIGR01013 324602008325 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 324602008326 Ligand Binding Site [chemical binding]; other site 324602008327 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 324602008328 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 324602008329 Domain interface; other site 324602008330 Active site tetrad [active] 324602008331 Peptide binding site; other site 324602008332 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 324602008333 protein binding site [polypeptide binding]; other site 324602008334 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324602008335 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 324602008336 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602008337 homodimer interface [polypeptide binding]; other site 324602008338 catalytic residue [active] 324602008339 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 324602008340 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 324602008341 active site 324602008342 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 324602008343 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 324602008344 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl19058 324602008345 active site 324602008346 dimer interface [polypeptide binding]; other site 324602008347 NMT1/THI5 like; Region: NMT1; pfam09084 324602008348 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 324602008349 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 324602008350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602008351 dimer interface [polypeptide binding]; other site 324602008352 conserved gate region; other site 324602008353 putative PBP binding loops; other site 324602008354 ABC-ATPase subunit interface; other site 324602008355 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 324602008356 trehalose synthase; Region: treS_nterm; TIGR02456 324602008357 active site 324602008358 catalytic site [active] 324602008359 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 324602008360 putative homodimer interface [polypeptide binding]; other site 324602008361 putative homotetramer interface [polypeptide binding]; other site 324602008362 putative allosteric switch controlling residues; other site 324602008363 putative metal binding site [ion binding]; other site 324602008364 putative homodimer-homodimer interface [polypeptide binding]; other site 324602008365 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 324602008366 catalytic residues [active] 324602008367 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 324602008368 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 324602008369 dimer interface [polypeptide binding]; other site 324602008370 active site 324602008371 glycine-pyridoxal phosphate binding site [chemical binding]; other site 324602008372 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 324602008373 folate binding site [chemical binding]; other site 324602008374 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 324602008375 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 324602008376 polyphosphate kinase; Provisional; Region: PRK05443 324602008377 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 324602008378 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 324602008379 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 324602008380 putative domain interface [polypeptide binding]; other site 324602008381 putative active site [active] 324602008382 catalytic site [active] 324602008383 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 324602008384 putative domain interface [polypeptide binding]; other site 324602008385 putative active site [active] 324602008386 catalytic site [active] 324602008387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602008388 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324602008389 putative substrate translocation pore; other site 324602008390 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 324602008391 TIGR03663 family protein; Region: TIGR03663 324602008392 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 324602008393 Uncharacterized conserved protein [Function unknown]; Region: COG3391 324602008394 NHL repeat; Region: NHL; pfam01436 324602008395 SdiA-regulated; Region: SdiA-regulated; cl19046 324602008396 NHL repeat; Region: NHL; pfam01436 324602008397 NHL repeat; Region: NHL; pfam01436 324602008398 Phosphotransferase enzyme family; Region: APH; pfam01636 324602008399 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 324602008400 ATP binding site [chemical binding]; other site 324602008401 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 324602008402 putative active site [active] 324602008403 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 324602008404 putative active site [active] 324602008405 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 324602008406 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 324602008407 P-loop; other site 324602008408 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 324602008409 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 324602008410 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 324602008411 light-independent protochlorophyllide reductase, B subunit; Region: DPOR_BchB; TIGR01278 324602008412 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 324602008413 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 324602008414 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 324602008415 Tetratricopeptide repeat; Region: TPR_16; pfam13432 324602008416 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 324602008417 cobyric acid synthase; Provisional; Region: PRK00784 324602008418 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 324602008419 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 324602008420 catalytic triad [active] 324602008421 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 324602008422 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324602008423 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602008424 homodimer interface [polypeptide binding]; other site 324602008425 catalytic residue [active] 324602008426 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 324602008427 homotrimer interface [polypeptide binding]; other site 324602008428 Walker A motif; other site 324602008429 GTP binding site [chemical binding]; other site 324602008430 Walker B motif; other site 324602008431 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 324602008432 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 324602008433 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 324602008434 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 324602008435 catalytic triad [active] 324602008436 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 324602008437 active site 324602008438 SAM binding site [chemical binding]; other site 324602008439 homodimer interface [polypeptide binding]; other site 324602008440 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 324602008441 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 324602008442 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 324602008443 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 324602008444 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 324602008445 active site 324602008446 SAM binding site [chemical binding]; other site 324602008447 homodimer interface [polypeptide binding]; other site 324602008448 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 324602008449 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 324602008450 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 324602008451 active site 324602008452 SAM binding site [chemical binding]; other site 324602008453 homodimer interface [polypeptide binding]; other site 324602008454 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 324602008455 active site 324602008456 SAM binding site [chemical binding]; other site 324602008457 homodimer interface [polypeptide binding]; other site 324602008458 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 324602008459 active site 324602008460 putative homodimer interface [polypeptide binding]; other site 324602008461 SAM binding site [chemical binding]; other site 324602008462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 324602008463 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602008464 S-adenosylmethionine binding site [chemical binding]; other site 324602008465 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 324602008466 Precorrin-8X methylmutase; Region: CbiC; pfam02570 324602008467 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 324602008468 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 324602008469 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 324602008470 putative active site [active] 324602008471 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 324602008472 putative active site [active] 324602008473 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 324602008474 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 324602008475 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 324602008476 Walker A/P-loop; other site 324602008477 ATP binding site [chemical binding]; other site 324602008478 Q-loop/lid; other site 324602008479 ABC transporter signature motif; other site 324602008480 Walker B; other site 324602008481 D-loop; other site 324602008482 H-loop/switch region; other site 324602008483 Cobalt transport protein; Region: CbiQ; cl00463 324602008484 cobalt transport protein CbiN; Provisional; Region: PRK02898 324602008485 cobalt transport protein CbiM; Validated; Region: PRK08319 324602008486 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 324602008487 putative dimer interface [polypeptide binding]; other site 324602008488 active site pocket [active] 324602008489 putative cataytic base [active] 324602008490 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 324602008491 [2Fe-2S] cluster binding site [ion binding]; other site 324602008492 dimer interface [polypeptide binding]; other site 324602008493 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 324602008494 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 324602008495 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 324602008496 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 324602008497 homodimer interface [polypeptide binding]; other site 324602008498 Walker A motif; other site 324602008499 ATP binding site [chemical binding]; other site 324602008500 hydroxycobalamin binding site [chemical binding]; other site 324602008501 Walker B motif; other site 324602008502 Cupredoxin superfamily; Region: Cupredoxin; cl19115 324602008503 Ubiquitin-like proteins; Region: UBQ; cl00155 324602008504 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 324602008505 VPS10 domain; Region: VPS10; smart00602 324602008506 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 324602008507 threonine dehydratase; Reviewed; Region: PRK09224 324602008508 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 324602008509 tetramer interface [polypeptide binding]; other site 324602008510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602008511 catalytic residue [active] 324602008512 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 324602008513 putative Ile/Val binding site [chemical binding]; other site 324602008514 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 324602008515 putative Ile/Val binding site [chemical binding]; other site 324602008516 GAF domain; Region: GAF_2; pfam13185 324602008517 GAF domain; Region: GAF_3; pfam13492 324602008518 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324602008519 metal binding site [ion binding]; metal-binding site 324602008520 active site 324602008521 I-site; other site 324602008522 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 324602008523 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 324602008524 tetramer interface [polypeptide binding]; other site 324602008525 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602008526 catalytic residue [active] 324602008527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602008528 S-adenosylmethionine binding site [chemical binding]; other site 324602008529 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 324602008530 magnesium-protoporphyrin IX monomethyl ester cyclase; Provisional; Region: PRK13654 324602008531 dinuclear metal binding motif [ion binding]; other site 324602008532 magnesium chelatase subunit H; Provisional; Region: PRK12493 324602008533 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 324602008534 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 324602008535 PUCC protein; Region: PUCC; pfam03209 324602008536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602008537 putative substrate translocation pore; other site 324602008538 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 324602008539 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 324602008540 tRNA; other site 324602008541 putative tRNA binding site [nucleotide binding]; other site 324602008542 putative NADP binding site [chemical binding]; other site 324602008543 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 324602008544 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 324602008545 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 324602008546 domain interfaces; other site 324602008547 active site 324602008548 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 324602008549 active site 324602008550 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 324602008551 dimer interface [polypeptide binding]; other site 324602008552 active site 324602008553 Schiff base residues; other site 324602008554 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 324602008555 substrate binding site [chemical binding]; other site 324602008556 active site 324602008557 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 324602008558 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 324602008559 inhibitor-cofactor binding pocket; inhibition site 324602008560 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602008561 catalytic residue [active] 324602008562 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 324602008563 oligoendopeptidase F; Region: pepF; TIGR00181 324602008564 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 324602008565 active site 324602008566 Zn binding site [ion binding]; other site 324602008567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602008568 putative substrate translocation pore; other site 324602008569 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324602008570 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 324602008571 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 324602008572 active site 324602008573 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 324602008574 Peptidase family M23; Region: Peptidase_M23; pfam01551 324602008575 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 324602008576 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 324602008577 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 324602008578 Flagellar FliJ protein; Region: FliJ; pfam02050 324602008579 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 324602008580 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 324602008581 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 324602008582 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 324602008583 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 324602008584 metal ion-dependent adhesion site (MIDAS); other site 324602008585 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 324602008586 metal ion-dependent adhesion site (MIDAS); other site 324602008587 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 324602008588 FixH; Region: FixH; cl19376 324602008589 GAF domain; Region: GAF_2; pfam13185 324602008590 GAF domain; Region: GAF_2; pfam13185 324602008591 GAF domain; Region: GAF_2; pfam13185 324602008592 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 324602008593 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 324602008594 GAF domain; Region: GAF_2; pfam13185 324602008595 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 324602008596 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 324602008597 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 324602008598 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 324602008599 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 324602008600 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 324602008601 Cytochrome P450; Region: p450; pfam00067 324602008602 short chain dehydrogenase; Provisional; Region: PRK12829 324602008603 classical (c) SDRs; Region: SDR_c; cd05233 324602008604 NAD(P) binding site [chemical binding]; other site 324602008605 active site 324602008606 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 324602008607 classical (c) SDRs; Region: SDR_c; cd05233 324602008608 NAD(P) binding site [chemical binding]; other site 324602008609 active site 324602008610 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 324602008611 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 324602008612 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 324602008613 inhibitor-cofactor binding pocket; inhibition site 324602008614 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602008615 catalytic residue [active] 324602008616 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 324602008617 catalytic residues [active] 324602008618 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 324602008619 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 324602008620 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324602008621 Coenzyme A binding pocket [chemical binding]; other site 324602008622 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 324602008623 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602008624 S-adenosylmethionine binding site [chemical binding]; other site 324602008625 Transcriptional regulators [Transcription]; Region: MarR; COG1846 324602008626 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 324602008627 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 324602008628 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 324602008629 Competence protein; Region: Competence; pfam03772 324602008630 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 324602008631 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 324602008632 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324602008633 Histidine kinase; Region: HisKA_3; pfam07730 324602008634 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602008635 ATP binding site [chemical binding]; other site 324602008636 Mg2+ binding site [ion binding]; other site 324602008637 G-X-G motif; other site 324602008638 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324602008639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602008640 active site 324602008641 phosphorylation site [posttranslational modification] 324602008642 intermolecular recognition site; other site 324602008643 dimerization interface [polypeptide binding]; other site 324602008644 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324602008645 DNA binding residues [nucleotide binding] 324602008646 dimerization interface [polypeptide binding]; other site 324602008647 Methyltransferase domain; Region: Methyltransf_31; pfam13847 324602008648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602008649 S-adenosylmethionine binding site [chemical binding]; other site 324602008650 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 324602008651 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 324602008652 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 324602008653 GAF domain; Region: GAF_3; pfam13492 324602008654 PAS domain; Region: PAS; smart00091 324602008655 PAS domain; Region: PAS_9; pfam13426 324602008656 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 324602008657 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 324602008658 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 324602008659 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 324602008660 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 324602008661 active site 324602008662 dimer interface [polypeptide binding]; other site 324602008663 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 324602008664 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 324602008665 metal binding site [ion binding]; metal-binding site 324602008666 dimer interface [polypeptide binding]; other site 324602008667 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 324602008668 Potassium binding sites [ion binding]; other site 324602008669 Cesium cation binding sites [ion binding]; other site 324602008670 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 324602008671 Subtilase family; Region: Peptidase_S8; pfam00082 324602008672 active site 324602008673 catalytic triad [active] 324602008674 Domain of unknown function (DUF4480); Region: DUF4480; pfam13715 324602008675 translocation protein TolB; Provisional; Region: tolB; PRK02889 324602008676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602008677 active site 324602008678 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324602008679 phosphorylation site [posttranslational modification] 324602008680 intermolecular recognition site; other site 324602008681 dimerization interface [polypeptide binding]; other site 324602008682 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324602008683 DNA binding residues [nucleotide binding] 324602008684 dimerization interface [polypeptide binding]; other site 324602008685 DNA polymerase III subunit beta; Validated; Region: PRK05643 324602008686 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 324602008687 putative DNA binding surface [nucleotide binding]; other site 324602008688 dimer interface [polypeptide binding]; other site 324602008689 beta-clamp/clamp loader binding surface; other site 324602008690 beta-clamp/translesion DNA polymerase binding surface; other site 324602008691 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 324602008692 active site 324602008693 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 324602008694 active site 324602008695 GTP cyclohydrolase I; Region: GTP_cyclohydroI; pfam01227 324602008696 active site 324602008697 short chain dehydrogenase; Provisional; Region: PRK07454 324602008698 classical (c) SDRs; Region: SDR_c; cd05233 324602008699 NAD(P) binding site [chemical binding]; other site 324602008700 active site 324602008701 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 324602008702 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 324602008703 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 324602008704 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 324602008705 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 324602008706 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 324602008707 putative trimer interface [polypeptide binding]; other site 324602008708 putative CoA binding site [chemical binding]; other site 324602008709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602008710 active site 324602008711 phosphorylation site [posttranslational modification] 324602008712 intermolecular recognition site; other site 324602008713 dimerization interface [polypeptide binding]; other site 324602008714 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 324602008715 nucleotidyl binding site; other site 324602008716 metal binding site [ion binding]; metal-binding site 324602008717 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 324602008718 GAF domain; Region: GAF; pfam01590 324602008719 GAF domain; Region: GAF_2; pfam13185 324602008720 GAF domain; Region: GAF_3; pfam13492 324602008721 GAF domain; Region: GAF_2; pfam13185 324602008722 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 324602008723 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 324602008724 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 324602008725 GAF domain; Region: GAF_2; pfam13185 324602008726 GAF domain; Region: GAF; pfam01590 324602008727 GAF domain; Region: GAF; pfam01590 324602008728 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 324602008729 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 324602008730 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602008731 putative active site [active] 324602008732 heme pocket [chemical binding]; other site 324602008733 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602008734 dimer interface [polypeptide binding]; other site 324602008735 phosphorylation site [posttranslational modification] 324602008736 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602008737 ATP binding site [chemical binding]; other site 324602008738 Mg2+ binding site [ion binding]; other site 324602008739 G-X-G motif; other site 324602008740 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324602008741 Putative lysophospholipase; Region: Hydrolase_4; cl19140 324602008742 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 324602008743 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 324602008744 active site 324602008745 HIGH motif; other site 324602008746 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 324602008747 KMSKS motif; other site 324602008748 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 324602008749 tRNA binding surface [nucleotide binding]; other site 324602008750 anticodon binding site; other site 324602008751 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 324602008752 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 324602008753 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 324602008754 Walker A/P-loop; other site 324602008755 ATP binding site [chemical binding]; other site 324602008756 Q-loop/lid; other site 324602008757 ABC transporter signature motif; other site 324602008758 Walker B; other site 324602008759 D-loop; other site 324602008760 H-loop/switch region; other site 324602008761 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 324602008762 Double zinc ribbon; Region: DZR; pfam12773 324602008763 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 324602008764 Bacterial type III secretion protein (HrpB7); Region: HrpB7; cl09720 324602008765 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 324602008766 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 324602008767 phosphopeptide binding site; other site 324602008768 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 324602008769 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 324602008770 metal ion-dependent adhesion site (MIDAS); other site 324602008771 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 324602008772 Double zinc ribbon; Region: DZR; pfam12773 324602008773 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 324602008774 Catalytic domain of Protein Kinases; Region: PKc; cd00180 324602008775 active site 324602008776 ATP binding site [chemical binding]; other site 324602008777 substrate binding site [chemical binding]; other site 324602008778 activation loop (A-loop); other site 324602008779 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 324602008780 Double zinc ribbon; Region: DZR; pfam12773 324602008781 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 324602008782 active site 324602008783 Double zinc ribbon; Region: DZR; pfam12773 324602008784 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 324602008785 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 324602008786 active site 324602008787 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 324602008788 Double zinc ribbon; Region: DZR; pfam12773 324602008789 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 324602008790 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 324602008791 phosphopeptide binding site; other site 324602008792 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 324602008793 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 324602008794 phosphopeptide binding site; other site 324602008795 The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955 324602008796 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324602008797 Walker A/P-loop; other site 324602008798 ATP binding site [chemical binding]; other site 324602008799 Q-loop/lid; other site 324602008800 ABC transporter signature motif; other site 324602008801 Walker B; other site 324602008802 D-loop; other site 324602008803 H-loop/switch region; other site 324602008804 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 324602008805 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 324602008806 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 324602008807 non-specific DNA binding site [nucleotide binding]; other site 324602008808 salt bridge; other site 324602008809 sequence-specific DNA binding site [nucleotide binding]; other site 324602008810 Cupin domain; Region: Cupin_2; pfam07883 324602008811 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 324602008812 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324602008813 Zn2+ binding site [ion binding]; other site 324602008814 Mg2+ binding site [ion binding]; other site 324602008815 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 324602008816 classical (c) SDRs; Region: SDR_c; cd05233 324602008817 NAD(P) binding site [chemical binding]; other site 324602008818 active site 324602008819 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 324602008820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602008821 S-adenosylmethionine binding site [chemical binding]; other site 324602008822 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 324602008823 putative substrate binding site [chemical binding]; other site 324602008824 putative ATP binding site [chemical binding]; other site 324602008825 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 324602008826 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 324602008827 active site 324602008828 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 324602008829 putative active site [active] 324602008830 metal binding site [ion binding]; metal-binding site 324602008831 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324602008832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602008833 ATP binding site [chemical binding]; other site 324602008834 Mg2+ binding site [ion binding]; other site 324602008835 G-X-G motif; other site 324602008836 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 324602008837 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 324602008838 Sulfatase; Region: Sulfatase; cl19157 324602008839 Thioredoxin; Region: Thioredoxin_4; pfam13462 324602008840 Transcriptional regulators [Transcription]; Region: MarR; COG1846 324602008841 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324602008842 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324602008843 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 324602008844 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 324602008845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602008846 dimer interface [polypeptide binding]; other site 324602008847 conserved gate region; other site 324602008848 putative PBP binding loops; other site 324602008849 ABC-ATPase subunit interface; other site 324602008850 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324602008851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602008852 dimer interface [polypeptide binding]; other site 324602008853 conserved gate region; other site 324602008854 putative PBP binding loops; other site 324602008855 ABC-ATPase subunit interface; other site 324602008856 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 324602008857 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 324602008858 dimer interface [polypeptide binding]; other site 324602008859 active site 324602008860 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 324602008861 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 324602008862 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 324602008863 metal ion-dependent adhesion site (MIDAS); other site 324602008864 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 324602008865 Predicted membrane protein (DUF2085); Region: DUF2085; cl01570 324602008866 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 324602008867 active site lid residues [active] 324602008868 substrate binding pocket [chemical binding]; other site 324602008869 catalytic residues [active] 324602008870 substrate-Mg2+ binding site; other site 324602008871 aspartate-rich region 1; other site 324602008872 aspartate-rich region 2; other site 324602008873 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 324602008874 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 324602008875 DNA binding residues [nucleotide binding] 324602008876 B12 binding domain; Region: B12-binding_2; pfam02607 324602008877 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 324602008878 B12 binding site [chemical binding]; other site 324602008879 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 324602008880 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 324602008881 NADP-binding site; other site 324602008882 homotetramer interface [polypeptide binding]; other site 324602008883 substrate binding site [chemical binding]; other site 324602008884 homodimer interface [polypeptide binding]; other site 324602008885 active site 324602008886 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 324602008887 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 324602008888 active site 324602008889 Substrate binding site; other site 324602008890 Mg++ binding site; other site 324602008891 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 324602008892 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 324602008893 putative trimer interface [polypeptide binding]; other site 324602008894 putative CoA binding site [chemical binding]; other site 324602008895 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 324602008896 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 324602008897 Ligand Binding Site [chemical binding]; other site 324602008898 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 324602008899 elongation factor G; Reviewed; Region: PRK12740 324602008900 G1 box; other site 324602008901 putative GEF interaction site [polypeptide binding]; other site 324602008902 GTP/Mg2+ binding site [chemical binding]; other site 324602008903 Switch I region; other site 324602008904 G2 box; other site 324602008905 G3 box; other site 324602008906 Switch II region; other site 324602008907 G4 box; other site 324602008908 G5 box; other site 324602008909 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 324602008910 Elongation Factor G, domain II; Region: EFG_II; pfam14492 324602008911 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 324602008912 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 324602008913 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 324602008914 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 324602008915 active site 324602008916 HIGH motif; other site 324602008917 KMSKS motif; other site 324602008918 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 324602008919 tRNA binding surface [nucleotide binding]; other site 324602008920 anticodon binding site; other site 324602008921 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 324602008922 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 324602008923 protein binding site [polypeptide binding]; other site 324602008924 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 324602008925 histidinol dehydrogenase; Region: hisD; TIGR00069 324602008926 NAD binding site [chemical binding]; other site 324602008927 dimerization interface [polypeptide binding]; other site 324602008928 product binding site; other site 324602008929 substrate binding site [chemical binding]; other site 324602008930 zinc binding site [ion binding]; other site 324602008931 catalytic residues [active] 324602008932 YGGT family; Region: YGGT; pfam02325 324602008933 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602008934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602008935 S-adenosylmethionine binding site [chemical binding]; other site 324602008936 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 324602008937 active site 324602008938 hypothetical protein; Provisional; Region: PRK14678 324602008939 DEAD-like helicases superfamily; Region: DEXDc; smart00487 324602008940 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324602008941 ATP binding site [chemical binding]; other site 324602008942 putative Mg++ binding site [ion binding]; other site 324602008943 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324602008944 nucleotide binding region [chemical binding]; other site 324602008945 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 324602008946 ATP-binding site [chemical binding]; other site 324602008947 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 324602008948 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 324602008949 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 324602008950 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 324602008951 Uncharacterized conserved protein [Function unknown]; Region: COG4938 324602008952 AAA domain; Region: AAA_21; pfam13304 324602008953 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 324602008954 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 324602008955 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 324602008956 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 324602008957 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 324602008958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602008959 catalytic residue [active] 324602008960 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 324602008961 Trm112p-like protein; Region: Trm112p; cl01066 324602008962 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 324602008963 putative active site [active] 324602008964 putative metal binding site [ion binding]; other site 324602008965 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 324602008966 active site 324602008967 Uncharacterized conserved protein [Function unknown]; Region: COG1432 324602008968 LabA_like proteins; Region: LabA_like; cd06167 324602008969 putative metal binding site [ion binding]; other site 324602008970 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 324602008971 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 324602008972 Probable Catalytic site; other site 324602008973 metal-binding site 324602008974 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 324602008975 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 324602008976 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 324602008977 Walker A/P-loop; other site 324602008978 ATP binding site [chemical binding]; other site 324602008979 Q-loop/lid; other site 324602008980 ABC transporter signature motif; other site 324602008981 Walker B; other site 324602008982 D-loop; other site 324602008983 H-loop/switch region; other site 324602008984 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324602008985 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324602008986 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 324602008987 active site 324602008988 dimerization interface [polypeptide binding]; other site 324602008989 Radical SAM superfamily; Region: Radical_SAM; pfam04055 324602008990 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324602008991 FeS/SAM binding site; other site 324602008992 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 324602008993 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324602008994 Coenzyme A binding pocket [chemical binding]; other site 324602008995 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 324602008996 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 324602008997 phosphodiesterase; Provisional; Region: PRK12704 324602008998 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; cl19511 324602008999 KH domain; Region: KH_1; pfam00013 324602009000 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324602009001 Zn2+ binding site [ion binding]; other site 324602009002 Mg2+ binding site [ion binding]; other site 324602009003 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 324602009004 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 324602009005 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 324602009006 ligand binding site [chemical binding]; other site 324602009007 flexible hinge region; other site 324602009008 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 324602009009 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 324602009010 metal binding triad; other site 324602009011 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 324602009012 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 324602009013 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 324602009014 active site 324602009015 catalytic site [active] 324602009016 substrate binding site [chemical binding]; other site 324602009017 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 324602009018 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 324602009019 transmembrane helices; other site 324602009020 TrkA-C domain; Region: TrkA_C; pfam02080 324602009021 TrkA-C domain; Region: TrkA_C; pfam02080 324602009022 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 324602009023 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 324602009024 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 324602009025 substrate binding [chemical binding]; other site 324602009026 active site 324602009027 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 324602009028 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324602009029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602009030 dimer interface [polypeptide binding]; other site 324602009031 conserved gate region; other site 324602009032 putative PBP binding loops; other site 324602009033 ABC-ATPase subunit interface; other site 324602009034 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 324602009035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602009036 conserved gate region; other site 324602009037 dimer interface [polypeptide binding]; other site 324602009038 putative PBP binding loops; other site 324602009039 ABC-ATPase subunit interface; other site 324602009040 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324602009041 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 324602009042 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 324602009043 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324602009044 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324602009045 DNA binding site [nucleotide binding] 324602009046 domain linker motif; other site 324602009047 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 324602009048 putative dimerization interface [polypeptide binding]; other site 324602009049 putative ligand binding site [chemical binding]; other site 324602009050 ParB-like nuclease domain; Region: ParBc; pfam02195 324602009051 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 324602009052 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 324602009053 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324602009054 NAD(P) binding site [chemical binding]; other site 324602009055 active site 324602009056 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 324602009057 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 324602009058 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 324602009059 ring oligomerisation interface [polypeptide binding]; other site 324602009060 ATP/Mg binding site [chemical binding]; other site 324602009061 stacking interactions; other site 324602009062 hinge regions; other site 324602009063 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 324602009064 oligomerisation interface [polypeptide binding]; other site 324602009065 mobile loop; other site 324602009066 roof hairpin; other site 324602009067 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 324602009068 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349; Region: Frankia_peptide; pfam14407 324602009069 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 324602009070 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 324602009071 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 324602009072 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 324602009073 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 324602009074 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 324602009075 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 324602009076 active site 324602009077 substrate binding pocket [chemical binding]; other site 324602009078 dimer interface [polypeptide binding]; other site 324602009079 tellurium resistance terB-like protein; Region: terB_like; cd07177 324602009080 metal binding site [ion binding]; metal-binding site 324602009081 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 324602009082 putative metal binding site [ion binding]; other site 324602009083 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 324602009084 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 324602009085 GAF domain; Region: GAF; cl17456 324602009086 GAF domain; Region: GAF_2; pfam13185 324602009087 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 324602009088 cyclase homology domain; Region: CHD; cd07302 324602009089 nucleotidyl binding site; other site 324602009090 metal binding site [ion binding]; metal-binding site 324602009091 dimer interface [polypeptide binding]; other site 324602009092 GAF domain; Region: GAF; pfam01590 324602009093 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 324602009094 PAS fold; Region: PAS_4; pfam08448 324602009095 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602009096 putative active site [active] 324602009097 heme pocket [chemical binding]; other site 324602009098 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324602009099 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602009100 phosphorylation site [posttranslational modification] 324602009101 dimer interface [polypeptide binding]; other site 324602009102 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602009103 ATP binding site [chemical binding]; other site 324602009104 Mg2+ binding site [ion binding]; other site 324602009105 G-X-G motif; other site 324602009106 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324602009107 dimerization interface [polypeptide binding]; other site 324602009108 GAF domain; Region: GAF; cl17456 324602009109 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 324602009110 PAS domain; Region: PAS; smart00091 324602009111 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602009112 dimer interface [polypeptide binding]; other site 324602009113 phosphorylation site [posttranslational modification] 324602009114 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602009115 ATP binding site [chemical binding]; other site 324602009116 Mg2+ binding site [ion binding]; other site 324602009117 G-X-G motif; other site 324602009118 Calx-beta domain; Region: Calx-beta; cl02522 324602009119 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 324602009120 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 324602009121 HIGH motif; other site 324602009122 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 324602009123 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 324602009124 active site 324602009125 KMSKS motif; other site 324602009126 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 324602009127 tRNA binding surface [nucleotide binding]; other site 324602009128 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 324602009129 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 324602009130 dimerization interface [polypeptide binding]; other site 324602009131 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 324602009132 ATP binding site [chemical binding]; other site 324602009133 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 324602009134 HupF/HypC family; Region: HupF_HypC; pfam01455 324602009135 NifU-like domain; Region: NifU; cl00484 324602009136 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 324602009137 iron-sulfur cluster [ion binding]; other site 324602009138 [2Fe-2S] cluster binding site [ion binding]; other site 324602009139 cysteinyl-tRNA synthetase; Provisional; Region: cysS; PRK14536 324602009140 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324602009141 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 324602009142 nickel binding site [ion binding]; other site 324602009143 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 324602009144 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 324602009145 NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720 324602009146 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 324602009147 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 324602009148 Protein of unknown function (DUF1641); Region: DUF1641; pfam07849 324602009149 Acylphosphatase; Region: Acylphosphatase; pfam00708 324602009150 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 324602009151 HypF finger; Region: zf-HYPF; pfam07503 324602009152 HypF finger; Region: zf-HYPF; pfam07503 324602009153 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 324602009154 PVL ORF-50-like family; Region: PVL_ORF50; pfam07768 324602009155 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 324602009156 Uncharacterized conserved protein [Function unknown]; Region: COG1262 324602009157 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; cl19582 324602009158 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 324602009159 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 324602009160 Lamin Tail Domain; Region: LTD; pfam00932 324602009161 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 324602009162 generic binding surface I; other site 324602009163 generic binding surface II; other site 324602009164 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 324602009165 putative active site [active] 324602009166 putative catalytic site [active] 324602009167 putative Mg binding site IVb [ion binding]; other site 324602009168 putative phosphate binding site [ion binding]; other site 324602009169 putative DNA binding site [nucleotide binding]; other site 324602009170 putative Mg binding site IVa [ion binding]; other site 324602009171 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 324602009172 proposed catalytic triad [active] 324602009173 active site nucleophile [active] 324602009174 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 324602009175 conserved cys residue [active] 324602009176 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 324602009177 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 324602009178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602009179 dimer interface [polypeptide binding]; other site 324602009180 conserved gate region; other site 324602009181 putative PBP binding loops; other site 324602009182 ABC-ATPase subunit interface; other site 324602009183 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 324602009184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602009185 dimer interface [polypeptide binding]; other site 324602009186 conserved gate region; other site 324602009187 putative PBP binding loops; other site 324602009188 ABC-ATPase subunit interface; other site 324602009189 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 324602009190 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 324602009191 peptide binding site [polypeptide binding]; other site 324602009192 dimer interface [polypeptide binding]; other site 324602009193 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 324602009194 proposed catalytic triad [active] 324602009195 active site nucleophile [active] 324602009196 Transcriptional regulators [Transcription]; Region: GntR; COG1802 324602009197 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324602009198 DNA-binding site [nucleotide binding]; DNA binding site 324602009199 FCD domain; Region: FCD; pfam07729 324602009200 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 324602009201 catalytic residues [active] 324602009202 dimer interface [polypeptide binding]; other site 324602009203 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 324602009204 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 324602009205 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 324602009206 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 324602009207 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 324602009208 putative metal binding site [ion binding]; other site 324602009209 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 324602009210 active site 324602009211 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 324602009212 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 324602009213 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 324602009214 DsrE/DsrF-like family; Region: DrsE; pfam02635 324602009215 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 324602009216 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 324602009217 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 324602009218 Predicted permease [General function prediction only]; Region: COG2985 324602009219 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 324602009220 TrkA-C domain; Region: TrkA_C; pfam02080 324602009221 TrkA-C domain; Region: TrkA_C; pfam02080 324602009222 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 324602009223 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 324602009224 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 324602009225 cofactor binding site; other site 324602009226 metal binding site [ion binding]; metal-binding site 324602009227 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 324602009228 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 324602009229 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 324602009230 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324602009231 NAD(P) binding site [chemical binding]; other site 324602009232 active site 324602009233 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 324602009234 active site 324602009235 intersubunit interactions; other site 324602009236 catalytic residue [active] 324602009237 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 324602009238 active site 324602009239 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 324602009240 transketolase; Reviewed; Region: PRK05899 324602009241 TPP-binding site [chemical binding]; other site 324602009242 PYR/PP interface [polypeptide binding]; other site 324602009243 dimer interface [polypeptide binding]; other site 324602009244 TPP binding site [chemical binding]; other site 324602009245 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 324602009246 HAS barrel domain; Region: HAS-barrel; pfam09378 324602009247 Domain of unknown function DUF87; Region: DUF87; pfam01935 324602009248 AAA-like domain; Region: AAA_10; pfam12846 324602009249 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602009250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602009251 active site 324602009252 phosphorylation site [posttranslational modification] 324602009253 intermolecular recognition site; other site 324602009254 dimerization interface [polypeptide binding]; other site 324602009255 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 324602009256 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324602009257 active site 324602009258 motif I; other site 324602009259 motif II; other site 324602009260 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 324602009261 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 324602009262 NAD binding site [chemical binding]; other site 324602009263 substrate binding site [chemical binding]; other site 324602009264 catalytic Zn binding site [ion binding]; other site 324602009265 tetramer interface [polypeptide binding]; other site 324602009266 structural Zn binding site [ion binding]; other site 324602009267 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324602009268 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 324602009269 active site 324602009270 motif I; other site 324602009271 motif II; other site 324602009272 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602009273 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 324602009274 Walker A motif; other site 324602009275 ATP binding site [chemical binding]; other site 324602009276 Walker B motif; other site 324602009277 arginine finger; other site 324602009278 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 324602009279 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 324602009280 metal ion-dependent adhesion site (MIDAS); other site 324602009281 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 324602009282 Cytochrome oxidase subunit II; Region: Cyto_ox_2; cl12219 324602009283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602009284 active site 324602009285 phosphorylation site [posttranslational modification] 324602009286 intermolecular recognition site; other site 324602009287 dimerization interface [polypeptide binding]; other site 324602009288 GAF domain; Region: GAF_2; pfam13185 324602009289 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602009290 dimer interface [polypeptide binding]; other site 324602009291 phosphorylation site [posttranslational modification] 324602009292 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602009293 ATP binding site [chemical binding]; other site 324602009294 Mg2+ binding site [ion binding]; other site 324602009295 G-X-G motif; other site 324602009296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602009297 active site 324602009298 phosphorylation site [posttranslational modification] 324602009299 intermolecular recognition site; other site 324602009300 dimerization interface [polypeptide binding]; other site 324602009301 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602009302 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602009303 active site 324602009304 phosphorylation site [posttranslational modification] 324602009305 intermolecular recognition site; other site 324602009306 dimerization interface [polypeptide binding]; other site 324602009307 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324602009308 metal binding site [ion binding]; metal-binding site 324602009309 active site 324602009310 I-site; other site 324602009311 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 324602009312 oligomer interface [polypeptide binding]; other site 324602009313 active site residues [active] 324602009314 Putative lysophospholipase; Region: Hydrolase_4; cl19140 324602009315 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324602009316 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 324602009317 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 324602009318 trmE is a tRNA modification GTPase; Region: trmE; cd04164 324602009319 G1 box; other site 324602009320 GTP/Mg2+ binding site [chemical binding]; other site 324602009321 Switch I region; other site 324602009322 G2 box; other site 324602009323 Switch II region; other site 324602009324 G3 box; other site 324602009325 G4 box; other site 324602009326 G5 box; other site 324602009327 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 324602009328 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 324602009329 substrate binding site [chemical binding]; other site 324602009330 hinge regions; other site 324602009331 ADP binding site [chemical binding]; other site 324602009332 catalytic site [active] 324602009333 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 324602009334 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 324602009335 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 324602009336 GAF domain; Region: GAF_3; pfam13492 324602009337 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 324602009338 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 324602009339 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602009340 dimer interface [polypeptide binding]; other site 324602009341 phosphorylation site [posttranslational modification] 324602009342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602009343 ATP binding site [chemical binding]; other site 324602009344 Mg2+ binding site [ion binding]; other site 324602009345 G-X-G motif; other site 324602009346 SEC-C motif; Region: SEC-C; pfam02810 324602009347 Uncharacterized conserved protein [Function unknown]; Region: COG1262 324602009348 Sulfatase-modifying factor enzyme 1; Region: FGE-sulfatase; cl19582 324602009349 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 324602009350 TPR repeat; Region: TPR_11; pfam13414 324602009351 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602009352 binding surface 324602009353 TPR motif; other site 324602009354 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602009355 binding surface 324602009356 TPR motif; other site 324602009357 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602009358 binding surface 324602009359 TPR motif; other site 324602009360 TPR repeat; Region: TPR_11; pfam13414 324602009361 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602009362 TPR motif; other site 324602009363 binding surface 324602009364 Tetratricopeptide repeat; Region: TPR_19; pfam14559 324602009365 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 324602009366 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602009367 binding surface 324602009368 TPR motif; other site 324602009369 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 324602009370 active site 324602009371 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 324602009372 metal ion-dependent adhesion site (MIDAS); other site 324602009373 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 324602009374 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 324602009375 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 324602009376 ATP-grasp domain; Region: ATP-grasp_4; cl17255 324602009377 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 324602009378 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 324602009379 carboxyltransferase (CT) interaction site; other site 324602009380 biotinylation site [posttranslational modification]; other site 324602009381 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 324602009382 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl19096 324602009383 Sortase family; Region: Sortase; pfam04203 324602009384 active site 324602009385 catalytic site [active] 324602009386 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 324602009387 Methyltransferase domain; Region: Methyltransf_26; pfam13659 324602009388 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 324602009389 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324602009390 metal binding site [ion binding]; metal-binding site 324602009391 active site 324602009392 lipoyl synthase; Provisional; Region: PRK05481 324602009393 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324602009394 FeS/SAM binding site; other site 324602009395 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 324602009396 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 324602009397 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324602009398 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 324602009399 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 324602009400 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324602009401 catalytic residue [active] 324602009402 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 324602009403 Queuine tRNA-ribosyltransferase; Region: TGT; cl19224 324602009404 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 324602009405 Ribosomal RNA methyltransferase (FmrO); Region: FmrO; pfam07091 324602009406 Low molecular weight phosphatase family; Region: LMWPc; cd00115 324602009407 active site 324602009408 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cl01843 324602009409 Sulfatase; Region: Sulfatase; cl19157 324602009410 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 324602009411 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 324602009412 RNA binding site [nucleotide binding]; other site 324602009413 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 324602009414 RNA binding site [nucleotide binding]; other site 324602009415 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 324602009416 RNA binding site [nucleotide binding]; other site 324602009417 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 324602009418 RNA binding site [nucleotide binding]; other site 324602009419 ornithine cyclodeaminase; Validated; Region: PRK08618 324602009420 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124 324602009421 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 324602009422 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 324602009423 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 324602009424 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 324602009425 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 324602009426 cyanophycin synthetase; Provisional; Region: PRK14016 324602009427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602009428 S-adenosylmethionine binding site [chemical binding]; other site 324602009429 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 324602009430 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 324602009431 Amylo-alpha-1,6-glucosidase; Region: GDE_C; cl19168 324602009432 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 324602009433 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 324602009434 active site 324602009435 metal binding site [ion binding]; metal-binding site 324602009436 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324602009437 Beta-propeller repeat; Region: SBBP; pfam06739 324602009438 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 324602009439 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 324602009440 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 324602009441 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 324602009442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602009443 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324602009444 putative substrate translocation pore; other site 324602009445 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602009446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602009447 active site 324602009448 phosphorylation site [posttranslational modification] 324602009449 intermolecular recognition site; other site 324602009450 dimerization interface [polypeptide binding]; other site 324602009451 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324602009452 DNA binding site [nucleotide binding] 324602009453 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 324602009454 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602009455 putative active site [active] 324602009456 heme pocket [chemical binding]; other site 324602009457 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602009458 dimer interface [polypeptide binding]; other site 324602009459 phosphorylation site [posttranslational modification] 324602009460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602009461 ATP binding site [chemical binding]; other site 324602009462 Mg2+ binding site [ion binding]; other site 324602009463 G-X-G motif; other site 324602009464 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 324602009465 Transcriptional regulators [Transcription]; Region: FadR; COG2186 324602009466 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 324602009467 DNA-binding site [nucleotide binding]; DNA binding site 324602009468 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 324602009469 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 324602009470 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 324602009471 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 324602009472 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 324602009473 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 324602009474 active site 324602009475 NTP binding site [chemical binding]; other site 324602009476 metal binding triad [ion binding]; metal-binding site 324602009477 antibiotic binding site [chemical binding]; other site 324602009478 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 324602009479 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 324602009480 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 324602009481 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 324602009482 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 324602009483 ADP-glucose phosphorylase; Region: PLN02643 324602009484 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 324602009485 nucleotide binding site/active site [active] 324602009486 HIT family signature motif; other site 324602009487 catalytic residue [active] 324602009488 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324602009489 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602009490 ATP binding site [chemical binding]; other site 324602009491 Mg2+ binding site [ion binding]; other site 324602009492 G-X-G motif; other site 324602009493 CHAT domain; Region: CHAT; pfam12770 324602009494 SIR2-like domain; Region: SIR2_2; pfam13289 324602009495 AAA ATPase domain; Region: AAA_16; pfam13191 324602009496 FOG: WD40 repeat [General function prediction only]; Region: COG2319 324602009497 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 324602009498 structural tetrad; other site 324602009499 FOG: WD40 repeat [General function prediction only]; Region: COG2319 324602009500 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 324602009501 structural tetrad; other site 324602009502 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 324602009503 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 324602009504 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 324602009505 Transcriptional regulators [Transcription]; Region: MarR; COG1846 324602009506 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 324602009507 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 324602009508 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 324602009509 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 324602009510 Walker A/P-loop; other site 324602009511 ATP binding site [chemical binding]; other site 324602009512 Q-loop/lid; other site 324602009513 ABC transporter signature motif; other site 324602009514 Walker B; other site 324602009515 D-loop; other site 324602009516 H-loop/switch region; other site 324602009517 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 324602009518 substrate binding site [chemical binding]; other site 324602009519 ATP binding site [chemical binding]; other site 324602009520 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 324602009521 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 324602009522 active site 324602009523 catalytic site [active] 324602009524 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 324602009525 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324602009526 motif II; other site 324602009527 cytoskeletal protein RodZ; Provisional; Region: PRK10856 324602009528 Peptidase S8 family domain, uncharacterized subfamily 3; Region: Peptidases_S8_3; cd04852 324602009529 active site 324602009530 catalytic triad [active] 324602009531 PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from...; Region: PA_subtilisin_like; cd02120 324602009532 PA/protease or protease-like domain interface [polypeptide binding]; other site 324602009533 Predicted membrane protein [Function unknown]; Region: COG2259 324602009534 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 324602009535 oligomerisation interface [polypeptide binding]; other site 324602009536 mobile loop; other site 324602009537 roof hairpin; other site 324602009538 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 324602009539 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 324602009540 ring oligomerisation interface [polypeptide binding]; other site 324602009541 ATP/Mg binding site [chemical binding]; other site 324602009542 stacking interactions; other site 324602009543 hinge regions; other site 324602009544 elongation factor P; Validated; Region: PRK00529 324602009545 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 324602009546 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 324602009547 RNA binding site [nucleotide binding]; other site 324602009548 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 324602009549 RNA binding site [nucleotide binding]; other site 324602009550 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 324602009551 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 324602009552 NAD binding site [chemical binding]; other site 324602009553 ligand binding site [chemical binding]; other site 324602009554 catalytic site [active] 324602009555 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 324602009556 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 324602009557 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602009558 homodimer interface [polypeptide binding]; other site 324602009559 catalytic residue [active] 324602009560 Transposase IS200 like; Region: Y1_Tnp; cl00848 324602009561 DDE superfamily endonuclease; Region: DDE_5; cl17874 324602009562 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 324602009563 FOG: CBS domain [General function prediction only]; Region: COG0517 324602009564 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 324602009565 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 324602009566 NADH dehydrogenase subunit B; Validated; Region: PRK06411 324602009567 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 324602009568 NADH dehydrogenase subunit D; Validated; Region: PRK06075 324602009569 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 324602009570 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 324602009571 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 324602009572 putative dimer interface [polypeptide binding]; other site 324602009573 [2Fe-2S] cluster binding site [ion binding]; other site 324602009574 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 324602009575 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 324602009576 SLBB domain; Region: SLBB; pfam10531 324602009577 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 324602009578 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 324602009579 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 324602009580 catalytic loop [active] 324602009581 iron binding site [ion binding]; other site 324602009582 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 324602009583 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 324602009584 molybdopterin cofactor binding site; other site 324602009585 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 324602009586 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 324602009587 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 324602009588 4Fe-4S binding domain; Region: Fer4; pfam00037 324602009589 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 324602009590 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 324602009591 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 324602009592 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 324602009593 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 324602009594 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 324602009595 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 324602009596 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 324602009597 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 324602009598 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 324602009599 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 324602009600 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 324602009601 NAD binding site [chemical binding]; other site 324602009602 homotetramer interface [polypeptide binding]; other site 324602009603 homodimer interface [polypeptide binding]; other site 324602009604 substrate binding site [chemical binding]; other site 324602009605 active site 324602009606 SurA N-terminal domain; Region: SurA_N_3; cl07813 324602009607 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 324602009608 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 324602009609 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 324602009610 DNA primase; Validated; Region: dnaG; PRK05667 324602009611 CHC2 zinc finger; Region: zf-CHC2; cl17510 324602009612 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 324602009613 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 324602009614 active site 324602009615 metal binding site [ion binding]; metal-binding site 324602009616 interdomain interaction site; other site 324602009617 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 324602009618 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 324602009619 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324602009620 Zn2+ binding site [ion binding]; other site 324602009621 Mg2+ binding site [ion binding]; other site 324602009622 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 324602009623 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 324602009624 active site 324602009625 PQQ-like domain; Region: PQQ_2; pfam13360 324602009626 Trp docking motif [polypeptide binding]; other site 324602009627 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 324602009628 PLD-like domain; Region: PLDc_2; pfam13091 324602009629 putative active site [active] 324602009630 catalytic site [active] 324602009631 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 324602009632 helicase superfamily c-terminal domain; Region: HELICc; smart00490 324602009633 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 324602009634 minor groove reading motif; other site 324602009635 helix-hairpin-helix signature motif; other site 324602009636 substrate binding pocket [chemical binding]; other site 324602009637 active site 324602009638 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 324602009639 cofactor binding site; other site 324602009640 DNA binding site [nucleotide binding] 324602009641 substrate interaction site [chemical binding]; other site 324602009642 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 324602009643 active site 324602009644 nucleotide binding site [chemical binding]; other site 324602009645 HIGH motif; other site 324602009646 KMSKS motif; other site 324602009647 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 324602009648 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 324602009649 Walker A/P-loop; other site 324602009650 ATP binding site [chemical binding]; other site 324602009651 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 324602009652 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 324602009653 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 324602009654 ABC transporter signature motif; other site 324602009655 Walker B; other site 324602009656 D-loop; other site 324602009657 H-loop/switch region; other site 324602009658 Recombination protein O N terminal; Region: RecO_N; pfam11967 324602009659 DNA repair protein RecO; Region: reco; TIGR00613 324602009660 Recombination protein O C terminal; Region: RecO_C; pfam02565 324602009661 Bacterial PH domain; Region: bPH_2; pfam03703 324602009662 Short C-terminal domain; Region: SHOCT; pfam09851 324602009663 purine nucleoside phosphorylase; Provisional; Region: PRK08202 324602009664 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 324602009665 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 324602009666 active site 324602009667 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 324602009668 putative active site [active] 324602009669 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 324602009670 active site 324602009671 Ap6A binding site [chemical binding]; other site 324602009672 nudix motif; other site 324602009673 metal binding site [ion binding]; metal-binding site 324602009674 Fructosamine kinase; Region: Fructosamin_kin; cl17579 324602009675 Phosphotransferase enzyme family; Region: APH; pfam01636 324602009676 PspC domain; Region: PspC; pfam04024 324602009677 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 324602009678 NAD+ binding site [chemical binding]; other site 324602009679 substrate binding site [chemical binding]; other site 324602009680 Zn binding site [ion binding]; other site 324602009681 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 324602009682 catalytic core [active] 324602009683 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 324602009684 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 324602009685 P loop; other site 324602009686 Nucleotide binding site [chemical binding]; other site 324602009687 DTAP/Switch II; other site 324602009688 Switch I; other site 324602009689 Arginase family; Region: Arginase; cd09989 324602009690 active site 324602009691 Mn binding site [ion binding]; other site 324602009692 oligomer interface [polypeptide binding]; other site 324602009693 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 324602009694 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324602009695 FeS/SAM binding site; other site 324602009696 histidyl-tRNA synthetase; Region: hisS; TIGR00442 324602009697 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 324602009698 dimer interface [polypeptide binding]; other site 324602009699 motif 1; other site 324602009700 active site 324602009701 motif 2; other site 324602009702 motif 3; other site 324602009703 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 324602009704 anticodon binding site; other site 324602009705 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 324602009706 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 324602009707 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 324602009708 Predicted transcriptional regulator [Transcription]; Region: COG2378 324602009709 WYL domain; Region: WYL; pfam13280 324602009710 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl18979 324602009711 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 324602009712 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693 324602009713 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 324602009714 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 324602009715 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639 324602009716 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 324602009717 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 324602009718 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 324602009719 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 324602009720 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 324602009721 MutS domain I; Region: MutS_I; pfam01624 324602009722 MutS domain II; Region: MutS_II; pfam05188 324602009723 MutS domain III; Region: MutS_III; pfam05192 324602009724 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 324602009725 Walker A/P-loop; other site 324602009726 ATP binding site [chemical binding]; other site 324602009727 Q-loop/lid; other site 324602009728 ABC transporter signature motif; other site 324602009729 Walker B; other site 324602009730 D-loop; other site 324602009731 H-loop/switch region; other site 324602009732 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 324602009733 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 324602009734 active site 324602009735 Riboflavin kinase; Region: Flavokinase; smart00904 324602009736 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 324602009737 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324602009738 NAD(P) binding site [chemical binding]; other site 324602009739 active site 324602009740 adenylate kinase; Reviewed; Region: adk; PRK00279 324602009741 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 324602009742 AMP-binding site [chemical binding]; other site 324602009743 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 324602009744 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 324602009745 Catalytic domain of Protein Kinases; Region: PKc; cd00180 324602009746 active site 324602009747 ATP binding site [chemical binding]; other site 324602009748 substrate binding site [chemical binding]; other site 324602009749 activation loop (A-loop); other site 324602009750 Spt5 C-terminal nonapeptide repeat binding Spt4; Region: CTD; smart01104 324602009751 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 324602009752 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602009753 binding surface 324602009754 TPR motif; other site 324602009755 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602009756 TPR motif; other site 324602009757 binding surface 324602009758 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 324602009759 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602009760 binding surface 324602009761 TPR motif; other site 324602009762 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602009763 binding surface 324602009764 TPR motif; other site 324602009765 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602009766 binding surface 324602009767 TPR motif; other site 324602009768 Domain of unknown function (DUF4628); Region: DUF4628; pfam15429 324602009769 Lamin Tail Domain; Region: LTD; pfam00932 324602009770 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 324602009771 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 324602009772 active site 324602009773 Substrate binding site; other site 324602009774 Mg++ binding site; other site 324602009775 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 324602009776 putative trimer interface [polypeptide binding]; other site 324602009777 putative CoA binding site [chemical binding]; other site 324602009778 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 324602009779 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 324602009780 HEAT repeats; Region: HEAT_2; pfam13646 324602009781 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 324602009782 RNA binding site [nucleotide binding]; other site 324602009783 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 324602009784 RNA binding site [nucleotide binding]; other site 324602009785 malonyl-CoA synthase; Validated; Region: PRK07514 324602009786 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 324602009787 acyl-activating enzyme (AAE) consensus motif; other site 324602009788 active site 324602009789 AMP binding site [chemical binding]; other site 324602009790 CoA binding site [chemical binding]; other site 324602009791 pyruvate phosphate dikinase; Provisional; Region: PRK09279 324602009792 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 324602009793 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 324602009794 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 324602009795 hydroxyproline-2-epimerase; Provisional; Region: PRK13971; cl19687 324602009796 Proline racemase; Region: Pro_racemase; pfam05544 324602009797 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 324602009798 Putative lysophospholipase; Region: Hydrolase_4; cl19140 324602009799 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324602009800 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 324602009801 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 324602009802 ligand binding site [chemical binding]; other site 324602009803 flexible hinge region; other site 324602009804 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 324602009805 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324602009806 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324602009807 NAD(P) binding site [chemical binding]; other site 324602009808 active site 324602009809 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 324602009810 active site 324602009811 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 324602009812 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 324602009813 GatB domain; Region: GatB_Yqey; smart00845 324602009814 Peroxidase, family 2; Region: Peroxidase_2; pfam01328 324602009815 Bacterial SH3 domain; Region: SH3_3; pfam08239 324602009816 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 324602009817 Double zinc ribbon; Region: DZR; pfam12773 324602009818 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 324602009819 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324602009820 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 324602009821 Ferritin-like domain; Region: Ferritin; pfam00210 324602009822 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 324602009823 dimerization interface [polypeptide binding]; other site 324602009824 DPS ferroxidase diiron center [ion binding]; other site 324602009825 ion pore; other site 324602009826 MoxR-like ATPases [General function prediction only]; Region: COG0714 324602009827 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602009828 Walker A motif; other site 324602009829 ATP binding site [chemical binding]; other site 324602009830 Walker B motif; other site 324602009831 arginine finger; other site 324602009832 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602009833 PAS domain; Region: PAS_9; pfam13426 324602009834 putative active site [active] 324602009835 heme pocket [chemical binding]; other site 324602009836 PAS domain S-box; Region: sensory_box; TIGR00229 324602009837 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602009838 putative active site [active] 324602009839 heme pocket [chemical binding]; other site 324602009840 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 324602009841 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602009842 putative active site [active] 324602009843 heme pocket [chemical binding]; other site 324602009844 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602009845 putative active site [active] 324602009846 heme pocket [chemical binding]; other site 324602009847 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324602009848 metal binding site [ion binding]; metal-binding site 324602009849 active site 324602009850 I-site; other site 324602009851 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 324602009852 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 324602009853 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 324602009854 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 324602009855 active site 324602009856 phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324 324602009857 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324602009858 Walker A/P-loop; other site 324602009859 ATP binding site [chemical binding]; other site 324602009860 Q-loop/lid; other site 324602009861 ABC transporter signature motif; other site 324602009862 Walker B; other site 324602009863 D-loop; other site 324602009864 H-loop/switch region; other site 324602009865 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 324602009866 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 324602009867 Walker A/P-loop; other site 324602009868 ATP binding site [chemical binding]; other site 324602009869 Q-loop/lid; other site 324602009870 ABC transporter signature motif; other site 324602009871 Walker B; other site 324602009872 D-loop; other site 324602009873 H-loop/switch region; other site 324602009874 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 324602009875 Phosphonate metabolizm protein PhnJ; Region: PhnJ; pfam06007 324602009876 Bacterial phosphonate metabolizm protein (PhnI); Region: PhnI; pfam05861 324602009877 phosphonate C-P lyase system protein PhnH; Region: PhnH_redo; TIGR03292 324602009878 phosphonate C-P lyase system protein PhnG; Region: PhnG_redo; TIGR03293 324602009879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602009880 dimer interface [polypeptide binding]; other site 324602009881 conserved gate region; other site 324602009882 ABC-ATPase subunit interface; other site 324602009883 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 324602009884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602009885 dimer interface [polypeptide binding]; other site 324602009886 conserved gate region; other site 324602009887 putative PBP binding loops; other site 324602009888 ABC-ATPase subunit interface; other site 324602009889 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 324602009890 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 324602009891 Walker A/P-loop; other site 324602009892 ATP binding site [chemical binding]; other site 324602009893 Q-loop/lid; other site 324602009894 ABC transporter signature motif; other site 324602009895 Walker B; other site 324602009896 D-loop; other site 324602009897 H-loop/switch region; other site 324602009898 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 324602009899 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 324602009900 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 324602009901 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324602009902 Coenzyme A binding pocket [chemical binding]; other site 324602009903 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 324602009904 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 324602009905 NADP binding site [chemical binding]; other site 324602009906 dimer interface [polypeptide binding]; other site 324602009907 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 324602009908 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 324602009909 hydrophobic ligand binding site; other site 324602009910 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 324602009911 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 324602009912 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 324602009913 active site 324602009914 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 324602009915 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 324602009916 active site 324602009917 PHP-associated; Region: PHP_C; pfam13263 324602009918 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324602009919 dimerization interface [polypeptide binding]; other site 324602009920 putative DNA binding site [nucleotide binding]; other site 324602009921 putative Zn2+ binding site [ion binding]; other site 324602009922 TspO/MBR family; Region: TspO_MBR; cl01379 324602009923 hypothetical protein; Provisional; Region: PRK08201 324602009924 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 324602009925 metal binding site [ion binding]; metal-binding site 324602009926 putative dimer interface [polypeptide binding]; other site 324602009927 DinB superfamily; Region: DinB_2; pfam12867 324602009928 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 324602009929 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 324602009930 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 324602009931 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 324602009932 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 324602009933 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602009934 ATP binding site [chemical binding]; other site 324602009935 Mg2+ binding site [ion binding]; other site 324602009936 G-X-G motif; other site 324602009937 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 324602009938 anchoring element; other site 324602009939 dimer interface [polypeptide binding]; other site 324602009940 ATP binding site [chemical binding]; other site 324602009941 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 324602009942 active site 324602009943 putative metal-binding site [ion binding]; other site 324602009944 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 324602009945 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 324602009946 NusA N-terminal domain; Region: NusA_N; pfam08529 324602009947 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 324602009948 RNA binding site [nucleotide binding]; other site 324602009949 homodimer interface [polypeptide binding]; other site 324602009950 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 324602009951 G-X-X-G motif; other site 324602009952 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 324602009953 G-X-X-G motif; other site 324602009954 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 324602009955 putative RNA binding cleft [nucleotide binding]; other site 324602009956 translation initiation factor IF-2; Validated; Region: infB; PRK05306 324602009957 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 324602009958 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 324602009959 G1 box; other site 324602009960 putative GEF interaction site [polypeptide binding]; other site 324602009961 GTP/Mg2+ binding site [chemical binding]; other site 324602009962 Switch I region; other site 324602009963 G2 box; other site 324602009964 G3 box; other site 324602009965 Switch II region; other site 324602009966 G4 box; other site 324602009967 G5 box; other site 324602009968 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 324602009969 Translation-initiation factor 2; Region: IF-2; pfam11987 324602009970 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 324602009971 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 324602009972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602009973 S-adenosylmethionine binding site [chemical binding]; other site 324602009974 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 324602009975 DHH family; Region: DHH; pfam01368 324602009976 DHHA1 domain; Region: DHHA1; pfam02272 324602009977 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 324602009978 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 324602009979 RNA binding site [nucleotide binding]; other site 324602009980 active site 324602009981 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 324602009982 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 324602009983 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 324602009984 Angiomotin C terminal; Region: Angiomotin_C; pfam12240 324602009985 Uncharacterized conserved protein [Function unknown]; Region: COG1284 324602009986 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 324602009987 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 324602009988 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 324602009989 S-adenosylmethionine synthetase; Validated; Region: PRK05250 324602009990 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 324602009991 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 324602009992 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 324602009993 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 324602009994 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 324602009995 homotetramer interface [polypeptide binding]; other site 324602009996 ligand binding site [chemical binding]; other site 324602009997 catalytic site [active] 324602009998 NAD binding site [chemical binding]; other site 324602009999 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324602010000 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324602010001 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324602010002 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 324602010003 substrate binding site [chemical binding]; other site 324602010004 ATP binding site [chemical binding]; other site 324602010005 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 324602010006 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 324602010007 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 324602010008 Protein export membrane protein; Region: SecD_SecF; pfam02355 324602010009 protein-export membrane protein SecD; Region: secD; TIGR01129 324602010010 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 324602010011 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 324602010012 Thioredoxin; Region: Thioredoxin_4; pfam13462 324602010013 YceI-like domain; Region: YceI; pfam04264 324602010014 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 324602010015 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324602010016 Walker A/P-loop; other site 324602010017 ATP binding site [chemical binding]; other site 324602010018 Q-loop/lid; other site 324602010019 ABC transporter signature motif; other site 324602010020 Walker B; other site 324602010021 D-loop; other site 324602010022 H-loop/switch region; other site 324602010023 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 324602010024 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 324602010025 ABC-2 type transporter; Region: ABC2_membrane; cl17235 324602010026 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 324602010027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602010028 GAF domain; Region: GAF; pfam01590 324602010029 GAF domain; Region: GAF_2; pfam13185 324602010030 PAS domain; Region: PAS_8; pfam13188 324602010031 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 324602010032 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602010033 dimer interface [polypeptide binding]; other site 324602010034 phosphorylation site [posttranslational modification] 324602010035 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602010036 ATP binding site [chemical binding]; other site 324602010037 Mg2+ binding site [ion binding]; other site 324602010038 G-X-G motif; other site 324602010039 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 324602010040 dimer interface [polypeptide binding]; other site 324602010041 substrate binding site [chemical binding]; other site 324602010042 metal binding site [ion binding]; metal-binding site 324602010043 Rubrerythrin [Energy production and conversion]; Region: COG1592 324602010044 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 324602010045 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 324602010046 iron binding site [ion binding]; other site 324602010047 DinB superfamily; Region: DinB_2; pfam12867 324602010048 rod shape-determining protein MreB; Provisional; Region: PRK13930 324602010049 MreB and similar proteins; Region: MreB_like; cd10225 324602010050 nucleotide binding site [chemical binding]; other site 324602010051 Mg binding site [ion binding]; other site 324602010052 putative protofilament interaction site [polypeptide binding]; other site 324602010053 RodZ interaction site [polypeptide binding]; other site 324602010054 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK14735 324602010055 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 324602010056 gamma subunit interface [polypeptide binding]; other site 324602010057 epsilon subunit interface [polypeptide binding]; other site 324602010058 LBP interface [polypeptide binding]; other site 324602010059 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 324602010060 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 324602010061 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 324602010062 alpha subunit interaction interface [polypeptide binding]; other site 324602010063 Walker A motif; other site 324602010064 ATP binding site [chemical binding]; other site 324602010065 Walker B motif; other site 324602010066 inhibitor binding site; inhibition site 324602010067 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 324602010068 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 324602010069 core domain interface [polypeptide binding]; other site 324602010070 delta subunit interface [polypeptide binding]; other site 324602010071 epsilon subunit interface [polypeptide binding]; other site 324602010072 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 324602010073 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 324602010074 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 324602010075 beta subunit interaction interface [polypeptide binding]; other site 324602010076 Walker A motif; other site 324602010077 ATP binding site [chemical binding]; other site 324602010078 Walker B motif; other site 324602010079 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 324602010080 ATP synthase delta (OSCP) subunit; Region: OSCP; cl17210 324602010081 F0F1 ATP synthase subunit B; Provisional; Region: PRK14473 324602010082 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 324602010083 ATP synthase subunit C; Region: ATP-synt_C; cl00466 324602010084 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 324602010085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602010086 active site 324602010087 phosphorylation site [posttranslational modification] 324602010088 intermolecular recognition site; other site 324602010089 dimerization interface [polypeptide binding]; other site 324602010090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 324602010091 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 324602010092 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 324602010093 phosphate binding site [ion binding]; other site 324602010094 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 324602010095 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 324602010096 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 324602010097 carboxyltransferase (CT) interaction site; other site 324602010098 biotinylation site [posttranslational modification]; other site 324602010099 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 324602010100 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 324602010101 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 324602010102 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 324602010103 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602010104 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324602010105 putative substrate translocation pore; other site 324602010106 YhhN-like protein; Region: YhhN; cl01505 324602010107 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 324602010108 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602010109 putative active site [active] 324602010110 heme pocket [chemical binding]; other site 324602010111 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602010112 putative active site [active] 324602010113 heme pocket [chemical binding]; other site 324602010114 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602010115 dimer interface [polypeptide binding]; other site 324602010116 phosphorylation site [posttranslational modification] 324602010117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602010118 ATP binding site [chemical binding]; other site 324602010119 Mg2+ binding site [ion binding]; other site 324602010120 G-X-G motif; other site 324602010121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602010122 active site 324602010123 phosphorylation site [posttranslational modification] 324602010124 intermolecular recognition site; other site 324602010125 dimerization interface [polypeptide binding]; other site 324602010126 response regulator PleD; Reviewed; Region: pleD; PRK09581 324602010127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602010128 active site 324602010129 phosphorylation site [posttranslational modification] 324602010130 intermolecular recognition site; other site 324602010131 dimerization interface [polypeptide binding]; other site 324602010132 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324602010133 metal binding site [ion binding]; metal-binding site 324602010134 active site 324602010135 I-site; other site 324602010136 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 324602010137 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 324602010138 Walker A/P-loop; other site 324602010139 ATP binding site [chemical binding]; other site 324602010140 Q-loop/lid; other site 324602010141 ABC transporter signature motif; other site 324602010142 Walker B; other site 324602010143 D-loop; other site 324602010144 H-loop/switch region; other site 324602010145 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 324602010146 GTP-binding protein LepA; Provisional; Region: PRK05433 324602010147 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 324602010148 G1 box; other site 324602010149 putative GEF interaction site [polypeptide binding]; other site 324602010150 GTP/Mg2+ binding site [chemical binding]; other site 324602010151 Switch I region; other site 324602010152 G2 box; other site 324602010153 G3 box; other site 324602010154 Switch II region; other site 324602010155 G4 box; other site 324602010156 G5 box; other site 324602010157 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 324602010158 Elongation Factor G, domain II; Region: EFG_II; pfam14492 324602010159 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 324602010160 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 324602010161 SurA N-terminal domain; Region: SurA_N; pfam09312 324602010162 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 324602010163 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 324602010164 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 324602010165 homodimer interface [polypeptide binding]; other site 324602010166 metal binding site [ion binding]; metal-binding site 324602010167 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 324602010168 homodimer interface [polypeptide binding]; other site 324602010169 active site 324602010170 putative chemical substrate binding site [chemical binding]; other site 324602010171 metal binding site [ion binding]; metal-binding site 324602010172 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 324602010173 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 324602010174 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 324602010175 active site 324602010176 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 324602010177 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 324602010178 prohibitin homologues; Region: PHB; smart00244 324602010179 Uncharacterized prokaryotic subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_eoslipins_u1; cd08826 324602010180 trimer interface [polypeptide binding]; other site 324602010181 EamA-like transporter family; Region: EamA; pfam00892 324602010182 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 324602010183 EamA-like transporter family; Region: EamA; pfam00892 324602010184 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 324602010185 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 324602010186 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 324602010187 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324602010188 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 324602010189 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324602010190 DNA binding residues [nucleotide binding] 324602010191 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 324602010192 active site 324602010193 catalytic site [active] 324602010194 substrate binding site [chemical binding]; other site 324602010195 WYL domain; Region: WYL; cl14852 324602010196 Bacterial SH3 domain; Region: SH3_3; pfam08239 324602010197 Bacterial SH3 domain; Region: SH3_3; pfam08239 324602010198 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 324602010199 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602010200 Walker A motif; other site 324602010201 ATP binding site [chemical binding]; other site 324602010202 Walker B motif; other site 324602010203 arginine finger; other site 324602010204 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 324602010205 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 324602010206 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 324602010207 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 324602010208 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 324602010209 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324602010210 LysE type translocator; Region: LysE; cl00565 324602010211 Thiamine pyrophosphokinase; Region: TPK; cd07995 324602010212 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 324602010213 active site 324602010214 dimerization interface [polypeptide binding]; other site 324602010215 thiamine binding site [chemical binding]; other site 324602010216 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 324602010217 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 324602010218 active site 324602010219 NTP binding site [chemical binding]; other site 324602010220 metal binding triad [ion binding]; metal-binding site 324602010221 antibiotic binding site [chemical binding]; other site 324602010222 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 324602010223 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 324602010224 active site 324602010225 HIGH motif; other site 324602010226 dimer interface [polypeptide binding]; other site 324602010227 KMSKS motif; other site 324602010228 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 324602010229 RNA binding surface [nucleotide binding]; other site 324602010230 Bacterial transcriptional activator domain; Region: BTAD; smart01043 324602010231 AAA ATPase domain; Region: AAA_16; pfam13191 324602010232 Predicted ATPase [General function prediction only]; Region: COG3899 324602010233 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324602010234 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602010235 binding surface 324602010236 TPR motif; other site 324602010237 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324602010238 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 324602010239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602010240 active site 324602010241 phosphorylation site [posttranslational modification] 324602010242 intermolecular recognition site; other site 324602010243 dimerization interface [polypeptide binding]; other site 324602010244 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324602010245 metal binding site [ion binding]; metal-binding site 324602010246 active site 324602010247 I-site; other site 324602010248 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 324602010249 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 324602010250 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 324602010251 ATP binding site [chemical binding]; other site 324602010252 Mg++ binding site [ion binding]; other site 324602010253 motif III; other site 324602010254 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324602010255 nucleotide binding region [chemical binding]; other site 324602010256 ATP-binding site [chemical binding]; other site 324602010257 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 324602010258 RNA binding site [nucleotide binding]; other site 324602010259 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 324602010260 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602010261 Walker A motif; other site 324602010262 ATP binding site [chemical binding]; other site 324602010263 Walker B motif; other site 324602010264 arginine finger; other site 324602010265 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 324602010266 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 324602010267 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 324602010268 putative metal binding site; other site 324602010269 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 324602010270 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 324602010271 Bacterial SH3 domain; Region: SH3_3; pfam08239 324602010272 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 324602010273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602010274 active site 324602010275 phosphorylation site [posttranslational modification] 324602010276 intermolecular recognition site; other site 324602010277 dimerization interface [polypeptide binding]; other site 324602010278 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324602010279 Zn2+ binding site [ion binding]; other site 324602010280 Mg2+ binding site [ion binding]; other site 324602010281 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 324602010282 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 324602010283 putative NAD(P) binding site [chemical binding]; other site 324602010284 active site 324602010285 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 324602010286 HD domain; Region: HD_4; pfam13328 324602010287 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 324602010288 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 324602010289 active site 324602010290 catalytic residues [active] 324602010291 metal binding site [ion binding]; metal-binding site 324602010292 EamA-like transporter family; Region: EamA; pfam00892 324602010293 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 324602010294 EamA-like transporter family; Region: EamA; pfam00892 324602010295 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 324602010296 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 324602010297 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324602010298 ATP binding site [chemical binding]; other site 324602010299 putative Mg++ binding site [ion binding]; other site 324602010300 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 324602010301 nucleotide binding region [chemical binding]; other site 324602010302 ATP-binding site [chemical binding]; other site 324602010303 TRCF domain; Region: TRCF; pfam03461 324602010304 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 324602010305 Double zinc ribbon; Region: DZR; pfam12773 324602010306 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 324602010307 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324602010308 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602010309 dimer interface [polypeptide binding]; other site 324602010310 phosphorylation site [posttranslational modification] 324602010311 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602010312 ATP binding site [chemical binding]; other site 324602010313 Mg2+ binding site [ion binding]; other site 324602010314 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 324602010315 dimer interface [polypeptide binding]; other site 324602010316 ADP-ribose binding site [chemical binding]; other site 324602010317 active site 324602010318 nudix motif; other site 324602010319 metal binding site [ion binding]; metal-binding site 324602010320 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602010321 S-adenosylmethionine binding site [chemical binding]; other site 324602010322 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 324602010323 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 324602010324 LrgA family; Region: LrgA; pfam03788 324602010325 GTP-binding protein Der; Reviewed; Region: PRK00093 324602010326 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 324602010327 G1 box; other site 324602010328 GTP/Mg2+ binding site [chemical binding]; other site 324602010329 Switch I region; other site 324602010330 G2 box; other site 324602010331 Switch II region; other site 324602010332 G3 box; other site 324602010333 G4 box; other site 324602010334 G5 box; other site 324602010335 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 324602010336 G1 box; other site 324602010337 GTP/Mg2+ binding site [chemical binding]; other site 324602010338 Switch I region; other site 324602010339 G2 box; other site 324602010340 G3 box; other site 324602010341 Switch II region; other site 324602010342 G4 box; other site 324602010343 G5 box; other site 324602010344 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 324602010345 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 324602010346 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 324602010347 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 324602010348 active site 324602010349 catalytic site [active] 324602010350 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602010351 PAS domain; Region: PAS_9; pfam13426 324602010352 putative active site [active] 324602010353 heme pocket [chemical binding]; other site 324602010354 PAS fold; Region: PAS_3; pfam08447 324602010355 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602010356 putative active site [active] 324602010357 heme pocket [chemical binding]; other site 324602010358 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 324602010359 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602010360 dimer interface [polypeptide binding]; other site 324602010361 phosphorylation site [posttranslational modification] 324602010362 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602010363 ATP binding site [chemical binding]; other site 324602010364 Mg2+ binding site [ion binding]; other site 324602010365 G-X-G motif; other site 324602010366 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602010367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602010368 active site 324602010369 phosphorylation site [posttranslational modification] 324602010370 intermolecular recognition site; other site 324602010371 dimerization interface [polypeptide binding]; other site 324602010372 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 324602010373 putative binding surface; other site 324602010374 active site 324602010375 intracellular protease, PfpI family; Region: PfpI; TIGR01382 324602010376 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 324602010377 conserved cys residue [active] 324602010378 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 324602010379 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 324602010380 metal ion-dependent adhesion site (MIDAS); other site 324602010381 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 324602010382 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 324602010383 metal ion-dependent adhesion site (MIDAS); other site 324602010384 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 324602010385 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 324602010386 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 324602010387 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 324602010388 PT repeat; Region: PT; pfam04886 324602010389 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 324602010390 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324602010391 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324602010392 DNA binding residues [nucleotide binding] 324602010393 transcription termination factor Rho; Provisional; Region: PRK12678 324602010394 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 324602010395 ligand binding site [chemical binding]; other site 324602010396 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 324602010397 ligand binding site [chemical binding]; other site 324602010398 prohibitin homologues; Region: PHB; smart00244 324602010399 SPFH domain / Band 7 family; Region: Band_7; pfam01145 324602010400 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 324602010401 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 324602010402 SPFH domain / Band 7 family; Region: Band_7; pfam01145 324602010403 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 324602010404 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 324602010405 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 324602010406 putative dimer interface [polypeptide binding]; other site 324602010407 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 324602010408 tetramer interface [polypeptide binding]; other site 324602010409 TPP-binding site [chemical binding]; other site 324602010410 heterodimer interface [polypeptide binding]; other site 324602010411 phosphorylation loop region [posttranslational modification] 324602010412 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 324602010413 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 324602010414 alpha subunit interface [polypeptide binding]; other site 324602010415 TPP binding site [chemical binding]; other site 324602010416 heterodimer interface [polypeptide binding]; other site 324602010417 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 324602010418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602010419 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324602010420 putative substrate translocation pore; other site 324602010421 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 324602010422 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 324602010423 ADP binding site [chemical binding]; other site 324602010424 magnesium binding site [ion binding]; other site 324602010425 putative shikimate binding site; other site 324602010426 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 324602010427 Clp amino terminal domain; Region: Clp_N; pfam02861 324602010428 Clp amino terminal domain; Region: Clp_N; pfam02861 324602010429 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602010430 Walker A motif; other site 324602010431 ATP binding site [chemical binding]; other site 324602010432 Walker B motif; other site 324602010433 arginine finger; other site 324602010434 AAA domain; Region: AAA_23; pfam13476 324602010435 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602010436 Walker A motif; other site 324602010437 ATP binding site [chemical binding]; other site 324602010438 Walker B motif; other site 324602010439 arginine finger; other site 324602010440 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 324602010441 SLBB domain; Region: SLBB; pfam10531 324602010442 comEA protein; Region: comE; TIGR01259 324602010443 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 324602010444 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 324602010445 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 324602010446 domain interfaces; other site 324602010447 active site 324602010448 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 324602010449 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 324602010450 cobalamin binding residues [chemical binding]; other site 324602010451 putative BtuC binding residues; other site 324602010452 dimer interface [polypeptide binding]; other site 324602010453 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 324602010454 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 324602010455 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 324602010456 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 324602010457 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 324602010458 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 324602010459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602010460 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324602010461 putative substrate translocation pore; other site 324602010462 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 324602010463 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 324602010464 active site 324602010465 nucleophile elbow; other site 324602010466 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 324602010467 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 324602010468 Cupin; Region: Cupin_6; pfam12852 324602010469 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324602010470 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 324602010471 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324602010472 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 324602010473 AAA domain; Region: AAA_22; pfam13401 324602010474 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324602010475 DNA binding residues [nucleotide binding] 324602010476 dimerization interface [polypeptide binding]; other site 324602010477 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 324602010478 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 324602010479 CAAX protease self-immunity; Region: Abi; pfam02517 324602010480 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 324602010481 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 324602010482 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324602010483 Coenzyme A binding pocket [chemical binding]; other site 324602010484 Beta-lactamase; Region: Beta-lactamase; pfam00144 324602010485 aconitate hydratase; Validated; Region: PRK09277 324602010486 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 324602010487 substrate binding site [chemical binding]; other site 324602010488 ligand binding site [chemical binding]; other site 324602010489 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 324602010490 substrate binding site [chemical binding]; other site 324602010491 magnesium chelatase subunit H; Provisional; Region: PRK12493 324602010492 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 324602010493 PT repeat; Region: PT; pfam04886 324602010494 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 324602010495 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 324602010496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602010497 dimer interface [polypeptide binding]; other site 324602010498 putative PBP binding loops; other site 324602010499 ABC-ATPase subunit interface; other site 324602010500 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324602010501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602010502 dimer interface [polypeptide binding]; other site 324602010503 conserved gate region; other site 324602010504 putative PBP binding loops; other site 324602010505 ABC-ATPase subunit interface; other site 324602010506 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 324602010507 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 324602010508 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 324602010509 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 324602010510 Putative esterase; Region: Esterase; pfam00756 324602010511 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 324602010512 FOG: WD40 repeat [General function prediction only]; Region: COG2319 324602010513 structural tetrad; other site 324602010514 Type II restriction endonuclease EcoO109I; Region: RE_EcoO109I; pfam14511 324602010515 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 324602010516 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 324602010517 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 324602010518 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 324602010519 catalytic core [active] 324602010520 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 324602010521 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 324602010522 FAD binding site [chemical binding]; other site 324602010523 homotetramer interface [polypeptide binding]; other site 324602010524 substrate binding pocket [chemical binding]; other site 324602010525 catalytic base [active] 324602010526 Putative lysophospholipase; Region: Hydrolase_4; cl19140 324602010527 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324602010528 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 324602010529 aromatic arch; other site 324602010530 DCoH dimer interaction site [polypeptide binding]; other site 324602010531 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 324602010532 DCoH tetramer interaction site [polypeptide binding]; other site 324602010533 substrate binding site [chemical binding]; other site 324602010534 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 324602010535 Glycine-rich region of argonaut; Region: Gly-rich_Ago1; pfam12764 324602010536 Thioredoxin; Region: Thioredoxin_4; pfam13462 324602010537 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 324602010538 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 324602010539 DNA binding residues [nucleotide binding] 324602010540 Protoglobin; Region: Protoglobin; pfam11563 324602010541 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 324602010542 dimer interface [polypeptide binding]; other site 324602010543 FMN binding site [chemical binding]; other site 324602010544 NADPH bind site [chemical binding]; other site 324602010545 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 324602010546 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602010547 Walker A motif; other site 324602010548 ATP binding site [chemical binding]; other site 324602010549 Walker B motif; other site 324602010550 Peptidase family M41; Region: Peptidase_M41; pfam01434 324602010551 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 324602010552 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 324602010553 substrate binding pocket [chemical binding]; other site 324602010554 membrane-bound complex binding site; other site 324602010555 hinge residues; other site 324602010556 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602010557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602010558 active site 324602010559 phosphorylation site [posttranslational modification] 324602010560 intermolecular recognition site; other site 324602010561 dimerization interface [polypeptide binding]; other site 324602010562 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324602010563 DNA binding site [nucleotide binding] 324602010564 GAF domain; Region: GAF; pfam01590 324602010565 HerA helicase [Replication, recombination, and repair]; Region: COG0433 324602010566 GAF domain; Region: GAF_2; pfam13185 324602010567 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602010568 dimer interface [polypeptide binding]; other site 324602010569 phosphorylation site [posttranslational modification] 324602010570 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602010571 ATP binding site [chemical binding]; other site 324602010572 Mg2+ binding site [ion binding]; other site 324602010573 G-X-G motif; other site 324602010574 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 324602010575 active site 324602010576 Domain of unknown function DUF59; Region: DUF59; pfam01883 324602010577 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 324602010578 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 324602010579 NAD binding site [chemical binding]; other site 324602010580 substrate binding site [chemical binding]; other site 324602010581 catalytic Zn binding site [ion binding]; other site 324602010582 structural Zn binding site [ion binding]; other site 324602010583 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 324602010584 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 324602010585 Cna protein B-type domain; Region: Cna_B; pfam05738 324602010586 CARDB; Region: CARDB; pfam07705 324602010587 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 324602010588 Protein of unknown function DUF58; Region: DUF58; pfam01882 324602010589 4-alpha-glucanotransferase; Provisional; Region: PRK14508 324602010590 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 324602010591 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 324602010592 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324602010593 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 324602010594 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324602010595 DNA binding residues [nucleotide binding] 324602010596 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 324602010597 classical (c) SDRs; Region: SDR_c; cd05233 324602010598 NAD(P) binding site [chemical binding]; other site 324602010599 active site 324602010600 PAS domain; Region: PAS; smart00091 324602010601 PAS fold; Region: PAS_7; pfam12860 324602010602 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 324602010603 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 324602010604 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 324602010605 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 324602010606 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 324602010607 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130 324602010608 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 324602010609 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 324602010610 Protein of unknown function DUF58; Region: DUF58; pfam01882 324602010611 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 324602010612 metal ion-dependent adhesion site (MIDAS); other site 324602010613 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 324602010614 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 324602010615 metal ion-dependent adhesion site (MIDAS); other site 324602010616 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 324602010617 Filamin/ABP280 repeat; Region: Filamin; cl19759 324602010618 Beta-lactamase; Region: Beta-lactamase; pfam00144 324602010619 Protein of unknown function, DUF393; Region: DUF393; pfam04134 324602010620 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 324602010621 nudix motif; other site 324602010622 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 324602010623 Glucokinase; Region: Glucokinase; pfam02685 324602010624 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 324602010625 substrate binding site [chemical binding]; other site 324602010626 hexamer interface [polypeptide binding]; other site 324602010627 metal binding site [ion binding]; metal-binding site 324602010628 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 324602010629 tetramer (dimer of dimers) interface [polypeptide binding]; other site 324602010630 active site 324602010631 dimer interface [polypeptide binding]; other site 324602010632 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 324602010633 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 324602010634 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 324602010635 Zn binding site [ion binding]; other site 324602010636 PDZ domain associated with archaeal and bacterial M61 glycyl-aminopeptidases. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to...; Region: PDZ_glycyl_aminopeptidase; cd00990 324602010637 protein binding site [polypeptide binding]; other site 324602010638 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 324602010639 This CD includes the respiratory arsenate reductase, As(V), catalytic subunit (ArrA) and other related proteins. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_Arsenate-R; cd02757 324602010640 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 324602010641 putative [Fe4-S4] binding site [ion binding]; other site 324602010642 putative molybdopterin cofactor binding site [chemical binding]; other site 324602010643 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 324602010644 putative molybdopterin cofactor binding site; other site 324602010645 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 324602010646 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 324602010647 Polysulphide reductase, NrfD; Region: NrfD; cl19193 324602010648 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 324602010649 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324602010650 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 324602010651 putative dimerization interface [polypeptide binding]; other site 324602010652 Domain of unknown function (DUF427); Region: DUF427; pfam04248 324602010653 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 324602010654 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 324602010655 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 324602010656 nudix motif; other site 324602010657 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 324602010658 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 324602010659 Bacterial self-protective colicin-like immunity; Region: Colicin_immun; pfam09204 324602010660 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 324602010661 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 324602010662 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 324602010663 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 324602010664 dimer interface [polypeptide binding]; other site 324602010665 active site 324602010666 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 324602010667 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 324602010668 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 324602010669 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 324602010670 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 324602010671 substrate binding site [chemical binding]; other site 324602010672 oxyanion hole (OAH) forming residues; other site 324602010673 trimer interface [polypeptide binding]; other site 324602010674 Predicted transcriptional regulator [Transcription]; Region: COG1959 324602010675 Rrf2 family protein; Region: rrf2_super; TIGR00738 324602010676 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 324602010677 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 324602010678 catalytic residues [active] 324602010679 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 324602010680 active site 324602010681 NTP binding site [chemical binding]; other site 324602010682 metal binding triad [ion binding]; metal-binding site 324602010683 antibiotic binding site [chemical binding]; other site 324602010684 HEPN domain; Region: HEPN; pfam05168 324602010685 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 324602010686 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 324602010687 GAF domain; Region: GAF_3; pfam13492 324602010688 GAF domain; Region: GAF_2; pfam13185 324602010689 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 324602010690 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 324602010691 Histidine kinase; Region: HisKA_3; pfam07730 324602010692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602010693 ATP binding site [chemical binding]; other site 324602010694 Mg2+ binding site [ion binding]; other site 324602010695 G-X-G motif; other site 324602010696 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324602010697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602010698 active site 324602010699 phosphorylation site [posttranslational modification] 324602010700 intermolecular recognition site; other site 324602010701 dimerization interface [polypeptide binding]; other site 324602010702 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324602010703 DNA binding residues [nucleotide binding] 324602010704 dimerization interface [polypeptide binding]; other site 324602010705 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 324602010706 Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN [Function unknown]; Region: COG2250 324602010707 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 324602010708 active site 324602010709 NTP binding site [chemical binding]; other site 324602010710 metal binding triad [ion binding]; metal-binding site 324602010711 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 324602010712 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 324602010713 substrate binding pocket [chemical binding]; other site 324602010714 membrane-bound complex binding site; other site 324602010715 hinge residues; other site 324602010716 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 324602010717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 324602010718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602010719 dimer interface [polypeptide binding]; other site 324602010720 conserved gate region; other site 324602010721 putative PBP binding loops; other site 324602010722 ABC-ATPase subunit interface; other site 324602010723 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 324602010724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602010725 dimer interface [polypeptide binding]; other site 324602010726 conserved gate region; other site 324602010727 putative PBP binding loops; other site 324602010728 ABC-ATPase subunit interface; other site 324602010729 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 324602010730 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 324602010731 Walker A/P-loop; other site 324602010732 ATP binding site [chemical binding]; other site 324602010733 Q-loop/lid; other site 324602010734 ABC transporter signature motif; other site 324602010735 Walker B; other site 324602010736 D-loop; other site 324602010737 H-loop/switch region; other site 324602010738 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602010739 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324602010740 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 324602010741 Septum formation initiator; Region: DivIC; pfam04977 324602010742 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 324602010743 cyclase homology domain; Region: CHD; cd07302 324602010744 nucleotidyl binding site; other site 324602010745 metal binding site [ion binding]; metal-binding site 324602010746 dimer interface [polypeptide binding]; other site 324602010747 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 324602010748 cyclase homology domain; Region: CHD; cd07302 324602010749 dimer interface [polypeptide binding]; other site 324602010750 nucleotidyl binding site; other site 324602010751 metal binding site [ion binding]; metal-binding site 324602010752 AAA ATPase domain; Region: AAA_16; pfam13191 324602010753 Predicted ATPase [General function prediction only]; Region: COG3899 324602010754 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 324602010755 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 324602010756 active site 324602010757 Protein of unknown function (DUF3714); Region: DUF3714; cl19909 324602010758 Azurin and similar redox proteins; Region: Azurin_like; cd13843 324602010759 Type 1 (T1) Cu binding site [ion binding]; other site 324602010760 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 324602010761 active site 324602010762 catalytic site [active] 324602010763 Helix-turn-helix domain; Region: HTH_17; pfam12728 324602010764 Trm112p-like protein; Region: Trm112p; pfam03966 324602010765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602010766 S-adenosylmethionine binding site [chemical binding]; other site 324602010767 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 324602010768 active site 324602010769 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602010770 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 324602010771 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 324602010772 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324602010773 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324602010774 NAD(P) binding site [chemical binding]; other site 324602010775 active site 324602010776 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 324602010777 O-antigen ligase like membrane protein; Region: O-antigen_lig; cl04850 324602010778 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 324602010779 Protein of unknown function (DUF3260); Region: DUF3260; cl11881 324602010780 CoA binding domain; Region: CoA_binding; cl17356 324602010781 Bacterial sugar transferase; Region: Bac_transf; pfam02397 324602010782 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 324602010783 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 324602010784 active site 324602010785 dimer interface [polypeptide binding]; other site 324602010786 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 324602010787 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 324602010788 active site 324602010789 FMN binding site [chemical binding]; other site 324602010790 substrate binding site [chemical binding]; other site 324602010791 3Fe-4S cluster binding site [ion binding]; other site 324602010792 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 324602010793 domain interface; other site 324602010794 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 324602010795 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 324602010796 HSP70 interaction site [polypeptide binding]; other site 324602010797 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 324602010798 substrate binding site [polypeptide binding]; other site 324602010799 dimer interface [polypeptide binding]; other site 324602010800 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 324602010801 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 324602010802 active site 324602010803 metal binding site [ion binding]; metal-binding site 324602010804 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 324602010805 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 324602010806 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 324602010807 NAD(P) binding site [chemical binding]; other site 324602010808 homotetramer interface [polypeptide binding]; other site 324602010809 homodimer interface [polypeptide binding]; other site 324602010810 active site 324602010811 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 324602010812 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 324602010813 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 324602010814 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 324602010815 CAAX protease self-immunity; Region: Abi; pfam02517 324602010816 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324602010817 dimerization interface [polypeptide binding]; other site 324602010818 putative DNA binding site [nucleotide binding]; other site 324602010819 putative Zn2+ binding site [ion binding]; other site 324602010820 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 324602010821 Predicted integral membrane protein [Function unknown]; Region: COG5658 324602010822 SdpI/YhfL protein family; Region: SdpI; pfam13630 324602010823 CAAX protease self-immunity; Region: Abi; pfam02517 324602010824 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 324602010825 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 324602010826 active site 324602010827 Zn binding site [ion binding]; other site 324602010828 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 324602010829 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 324602010830 Mechanosensitive ion channel; Region: MS_channel; pfam00924 324602010831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399; cl19827 324602010832 Protein of unknown function (DUF445); Region: DUF445; pfam04286 324602010833 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 324602010834 homodimer interface [polypeptide binding]; other site 324602010835 substrate-cofactor binding pocket; other site 324602010836 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602010837 catalytic residue [active] 324602010838 PAS domain; Region: PAS_9; pfam13426 324602010839 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602010840 putative active site [active] 324602010841 PAS fold; Region: PAS_4; pfam08448 324602010842 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 324602010843 tetramer interface [polypeptide binding]; other site 324602010844 dimer interface [polypeptide binding]; other site 324602010845 circadian clock protein KaiC; Reviewed; Region: PRK09302 324602010846 KaiC; Region: KaiC; pfam06745 324602010847 Walker A motif; other site 324602010848 ATP binding site [chemical binding]; other site 324602010849 Walker B motif; other site 324602010850 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 324602010851 Walker A motif; other site 324602010852 ATP binding site [chemical binding]; other site 324602010853 Walker B motif; other site 324602010854 PAS domain S-box; Region: sensory_box; TIGR00229 324602010855 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602010856 putative active site [active] 324602010857 PAS fold; Region: PAS_4; pfam08448 324602010858 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324602010859 metal binding site [ion binding]; metal-binding site 324602010860 active site 324602010861 I-site; other site 324602010862 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 324602010863 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 324602010864 classical (c) SDRs; Region: SDR_c; cd05233 324602010865 NAD(P) binding site [chemical binding]; other site 324602010866 active site 324602010867 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 324602010868 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 324602010869 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 324602010870 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 324602010871 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 324602010872 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 324602010873 homodimer interface [polypeptide binding]; other site 324602010874 NADP binding site [chemical binding]; other site 324602010875 substrate binding site [chemical binding]; other site 324602010876 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 324602010877 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 324602010878 ATP-grasp domain; Region: ATP-grasp_4; cl17255 324602010879 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 324602010880 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 324602010881 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324602010882 Coenzyme A binding pocket [chemical binding]; other site 324602010883 poly(hydroxyalkanoate) granule-associated protein; Region: PHA_granule_1; TIGR01837 324602010884 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 324602010885 Uncharacterized conserved protein [Function unknown]; Region: COG3937 324602010886 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 324602010887 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 324602010888 nucleophile elbow; other site 324602010889 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602010890 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324602010891 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 324602010892 Catalytic domain of Protein Kinases; Region: PKc; cd00180 324602010893 active site 324602010894 ATP binding site [chemical binding]; other site 324602010895 substrate binding site [chemical binding]; other site 324602010896 activation loop (A-loop); other site 324602010897 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 324602010898 FOG: WD40 repeat [General function prediction only]; Region: COG2319 324602010899 structural tetrad; other site 324602010900 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 324602010901 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 324602010902 Cysteine-rich domain; Region: CCG; pfam02754 324602010903 Cysteine-rich domain; Region: CCG; pfam02754 324602010904 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 324602010905 FAD binding domain; Region: FAD_binding_2; pfam00890 324602010906 glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377 324602010907 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 324602010908 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 324602010909 glycerol kinase; Provisional; Region: glpK; PRK00047 324602010910 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 324602010911 N- and C-terminal domain interface [polypeptide binding]; other site 324602010912 active site 324602010913 MgATP binding site [chemical binding]; other site 324602010914 catalytic site [active] 324602010915 metal binding site [ion binding]; metal-binding site 324602010916 putative homotetramer interface [polypeptide binding]; other site 324602010917 glycerol binding site [chemical binding]; other site 324602010918 homodimer interface [polypeptide binding]; other site 324602010919 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 324602010920 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 324602010921 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 324602010922 amphipathic channel; other site 324602010923 Asn-Pro-Ala signature motifs; other site 324602010924 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 324602010925 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 324602010926 Bacterial Ig-like domain; Region: Big_5; pfam13205 324602010927 Bacterial Ig-like domain; Region: Big_5; pfam13205 324602010928 Bacterial Ig-like domain; Region: Big_5; pfam13205 324602010929 Bacterial Ig-like domain; Region: Big_5; pfam13205 324602010930 MG2 domain; Region: A2M_N; cl19929 324602010931 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 324602010932 Phosphotransferase enzyme family; Region: APH; pfam01636 324602010933 active site 324602010934 substrate binding site [chemical binding]; other site 324602010935 ATP binding site [chemical binding]; other site 324602010936 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 324602010937 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 324602010938 active site 324602010939 catalytic triad [active] 324602010940 oxyanion hole [active] 324602010941 drug efflux system protein MdtG; Provisional; Region: PRK09874 324602010942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602010943 putative substrate translocation pore; other site 324602010944 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 324602010945 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 324602010946 putative active site pocket [active] 324602010947 dimerization interface [polypeptide binding]; other site 324602010948 putative catalytic residue [active] 324602010949 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 324602010950 putative active site; other site 324602010951 catalytic triad [active] 324602010952 putative dimer interface [polypeptide binding]; other site 324602010953 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 324602010954 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 324602010955 Protein of unknown function (DUF1501); Region: DUF1501; cl19855 324602010956 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 324602010957 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 324602010958 NAD(P) binding pocket [chemical binding]; other site 324602010959 Putative lysophospholipase; Region: Hydrolase_4; cl19140 324602010960 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324602010961 Probable pheophorbidase; Region: PLN02965; cl17657 324602010962 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 324602010963 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324602010964 Walker A/P-loop; other site 324602010965 ATP binding site [chemical binding]; other site 324602010966 Q-loop/lid; other site 324602010967 ABC transporter signature motif; other site 324602010968 Walker B; other site 324602010969 D-loop; other site 324602010970 H-loop/switch region; other site 324602010971 ABC-2 type transporter; Region: ABC2_membrane; cl17235 324602010972 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 324602010973 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 324602010974 CoenzymeA binding site [chemical binding]; other site 324602010975 subunit interaction site [polypeptide binding]; other site 324602010976 PHB binding site; other site 324602010977 Methyltransferase domain; Region: Methyltransf_31; pfam13847 324602010978 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602010979 S-adenosylmethionine binding site [chemical binding]; other site 324602010980 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 324602010981 SmpB-tmRNA interface; other site 324602010982 O-antigen ligase like membrane protein; Region: O-antigen_lig; cl04850 324602010983 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 324602010984 putative active site [active] 324602010985 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 324602010986 dimer interface [polypeptide binding]; other site 324602010987 substrate binding site [chemical binding]; other site 324602010988 metal binding sites [ion binding]; metal-binding site 324602010989 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 324602010990 active site 324602010991 Ap6A binding site [chemical binding]; other site 324602010992 nudix motif; other site 324602010993 metal binding site [ion binding]; metal-binding site 324602010994 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 324602010995 proteobacterial sortase system OmpA family protein; Region: pdsO; TIGR03789 324602010996 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 324602010997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602010998 S-adenosylmethionine binding site [chemical binding]; other site 324602010999 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 324602011000 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 324602011001 metal binding site [ion binding]; metal-binding site 324602011002 dimer interface [polypeptide binding]; other site 324602011003 short chain dehydrogenase; Provisional; Region: PRK06181 324602011004 classical (c) SDRs; Region: SDR_c; cd05233 324602011005 NAD(P) binding site [chemical binding]; other site 324602011006 active site 324602011007 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 324602011008 active site 324602011009 diiron metal binding site [ion binding]; other site 324602011010 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 324602011011 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349; Region: Frankia_peptide; pfam14407 324602011012 cyclase homology domain; Region: CHD; cd07302 324602011013 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 324602011014 nucleotidyl binding site; other site 324602011015 metal binding site [ion binding]; metal-binding site 324602011016 dimer interface [polypeptide binding]; other site 324602011017 cyclase homology domain; Region: CHD; cd07302 324602011018 nucleotidyl binding site; other site 324602011019 metal binding site [ion binding]; metal-binding site 324602011020 dimer interface [polypeptide binding]; other site 324602011021 AAA ATPase domain; Region: AAA_16; pfam13191 324602011022 Protein of unknown function (DUF1386); Region: DUF1386; pfam07138 324602011023 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 324602011024 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602011025 TPR motif; other site 324602011026 binding surface 324602011027 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602011028 binding surface 324602011029 TPR motif; other site 324602011030 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324602011031 Radical SAM superfamily; Region: Radical_SAM; pfam04055 324602011032 FeS/SAM binding site; other site 324602011033 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 324602011034 NAD(P) binding site [chemical binding]; other site 324602011035 catalytic residues [active] 324602011036 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 324602011037 active site 324602011038 purine riboside binding site [chemical binding]; other site 324602011039 homoserine dehydrogenase family protein; Region: PLN02700 324602011040 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 324602011041 multifunctional aminopeptidase A; Provisional; Region: PRK00913 324602011042 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 324602011043 interface (dimer of trimers) [polypeptide binding]; other site 324602011044 Substrate-binding/catalytic site; other site 324602011045 Zn-binding sites [ion binding]; other site 324602011046 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602011047 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 324602011048 putative active site [active] 324602011049 heme pocket [chemical binding]; other site 324602011050 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602011051 putative active site [active] 324602011052 heme pocket [chemical binding]; other site 324602011053 GAF domain; Region: GAF_2; pfam13185 324602011054 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602011055 dimer interface [polypeptide binding]; other site 324602011056 phosphorylation site [posttranslational modification] 324602011057 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602011058 ATP binding site [chemical binding]; other site 324602011059 Mg2+ binding site [ion binding]; other site 324602011060 G-X-G motif; other site 324602011061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602011062 active site 324602011063 phosphorylation site [posttranslational modification] 324602011064 intermolecular recognition site; other site 324602011065 dimerization interface [polypeptide binding]; other site 324602011066 OsmC-like protein; Region: OsmC; pfam02566 324602011067 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 324602011068 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 324602011069 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 324602011070 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 324602011071 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 324602011072 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 324602011073 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324602011074 Coenzyme A binding pocket [chemical binding]; other site 324602011075 argininosuccinate lyase; Provisional; Region: PRK00855 324602011076 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 324602011077 active sites [active] 324602011078 tetramer interface [polypeptide binding]; other site 324602011079 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 324602011080 heterotetramer interface [polypeptide binding]; other site 324602011081 active site pocket [active] 324602011082 cleavage site 324602011083 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 324602011084 catalytic core [active] 324602011085 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 324602011086 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 324602011087 AAA domain; Region: AAA_23; pfam13476 324602011088 AAA domain; Region: AAA_21; pfam13304 324602011089 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 324602011090 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 324602011091 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 324602011092 active site 324602011093 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 324602011094 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 324602011095 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 324602011096 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 324602011097 Double zinc ribbon; Region: DZR; pfam12773 324602011098 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 324602011099 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 324602011100 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 324602011101 phosphopeptide binding site; other site 324602011102 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 324602011103 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 324602011104 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324602011105 ASCH domain; Region: ASCH; pfam04266 324602011106 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 324602011107 active site 324602011108 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 324602011109 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 324602011110 inhibitor-cofactor binding pocket; inhibition site 324602011111 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602011112 catalytic residue [active] 324602011113 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324602011114 Coenzyme A binding pocket [chemical binding]; other site 324602011115 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 324602011116 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 324602011117 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 324602011118 dimerization interface [polypeptide binding]; other site 324602011119 ATP binding site [chemical binding]; other site 324602011120 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 324602011121 dimerization interface [polypeptide binding]; other site 324602011122 ATP binding site [chemical binding]; other site 324602011123 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 324602011124 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 324602011125 SpoIIAA-like; Region: SpoIIAA-like; pfam11964 324602011126 magnesium chelatase, H subunit; Region: BchH; TIGR02025 324602011127 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 324602011128 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 324602011129 Transcriptional regulators [Transcription]; Region: MarR; COG1846 324602011130 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 324602011131 putative Zn2+ binding site [ion binding]; other site 324602011132 putative DNA binding site [nucleotide binding]; other site 324602011133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602011134 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324602011135 putative substrate translocation pore; other site 324602011136 WYL domain; Region: WYL; pfam13280 324602011137 Catalytic domain of Protein Kinases; Region: PKc; cd00180 324602011138 active site 324602011139 ATP binding site [chemical binding]; other site 324602011140 substrate binding site [chemical binding]; other site 324602011141 activation loop (A-loop); other site 324602011142 Bacterial PH domain; Region: bPH_2; cl01348 324602011143 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324602011144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602011145 active site 324602011146 phosphorylation site [posttranslational modification] 324602011147 intermolecular recognition site; other site 324602011148 dimerization interface [polypeptide binding]; other site 324602011149 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324602011150 DNA binding residues [nucleotide binding] 324602011151 dimerization interface [polypeptide binding]; other site 324602011152 GAF domain; Region: GAF; pfam01590 324602011153 GAF domain; Region: GAF_2; pfam13185 324602011154 GAF domain; Region: GAF_2; pfam13185 324602011155 GAF domain; Region: GAF_3; pfam13492 324602011156 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 324602011157 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602011158 ATP binding site [chemical binding]; other site 324602011159 Mg2+ binding site [ion binding]; other site 324602011160 G-X-G motif; other site 324602011161 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6_III; cd09760 324602011162 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 324602011163 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09702 324602011164 Predicted transcriptional regulator [Transcription]; Region: COG2378 324602011165 WYL domain; Region: WYL; pfam13280 324602011166 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl19032 324602011167 RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI; Region: RNase_HI_like; cd09279 324602011168 RNA/DNA hybrid binding site [nucleotide binding]; other site 324602011169 active site 324602011170 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 324602011171 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 324602011172 putative active site [active] 324602011173 putative NTP binding site [chemical binding]; other site 324602011174 putative nucleic acid binding site [nucleotide binding]; other site 324602011175 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 324602011176 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 324602011177 WYL domain; Region: WYL; pfam13280 324602011178 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 324602011179 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 324602011180 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 324602011181 HSP70 interaction site [polypeptide binding]; other site 324602011182 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 324602011183 EVE domain; Region: EVE; pfam01878 324602011184 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602011185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602011186 active site 324602011187 phosphorylation site [posttranslational modification] 324602011188 intermolecular recognition site; other site 324602011189 dimerization interface [polypeptide binding]; other site 324602011190 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324602011191 DNA binding site [nucleotide binding] 324602011192 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324602011193 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324602011194 dimerization interface [polypeptide binding]; other site 324602011195 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602011196 dimer interface [polypeptide binding]; other site 324602011197 phosphorylation site [posttranslational modification] 324602011198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602011199 ATP binding site [chemical binding]; other site 324602011200 Mg2+ binding site [ion binding]; other site 324602011201 G-X-G motif; other site 324602011202 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 324602011203 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 324602011204 Na binding site [ion binding]; other site 324602011205 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 324602011206 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 324602011207 acyl-activating enzyme (AAE) consensus motif; other site 324602011208 putative AMP binding site [chemical binding]; other site 324602011209 putative active site [active] 324602011210 putative CoA binding site [chemical binding]; other site 324602011211 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 324602011212 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 324602011213 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 324602011214 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 324602011215 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 324602011216 Subtilase family; Region: Peptidase_S8; pfam00082 324602011217 active site 324602011218 catalytic triad [active] 324602011219 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324602011220 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324602011221 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 324602011222 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 324602011223 HlyD family secretion protein; Region: HlyD_3; pfam13437 324602011224 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 324602011225 MMPL family; Region: MMPL; cl14618 324602011226 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 324602011227 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 324602011228 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 324602011229 nucleotide binding site [chemical binding]; other site 324602011230 N-acetyl-L-glutamate binding site [chemical binding]; other site 324602011231 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 324602011232 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 324602011233 ligand binding site [chemical binding]; other site 324602011234 flexible hinge region; other site 324602011235 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 324602011236 non-specific DNA interactions [nucleotide binding]; other site 324602011237 DNA binding site [nucleotide binding] 324602011238 sequence specific DNA binding site [nucleotide binding]; other site 324602011239 putative cAMP binding site [chemical binding]; other site 324602011240 von Willebrand factor type A domain; Region: VWA_2; pfam13519 324602011241 Protein of unknown function (DUF402); Region: DUF402; pfam04167 324602011242 Protein of unknown function DUF58; Region: DUF58; pfam01882 324602011243 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 324602011244 metal ion-dependent adhesion site (MIDAS); other site 324602011245 MoxR-like ATPases [General function prediction only]; Region: COG0714 324602011246 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602011247 Walker A motif; other site 324602011248 ATP binding site [chemical binding]; other site 324602011249 Walker B motif; other site 324602011250 arginine finger; other site 324602011251 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 324602011252 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 324602011253 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 324602011254 AAA ATPase domain; Region: AAA_16; pfam13191 324602011255 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 324602011256 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324602011257 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324602011258 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602011259 binding surface 324602011260 TPR motif; other site 324602011261 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324602011262 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602011263 binding surface 324602011264 TPR motif; other site 324602011265 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324602011266 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324602011267 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602011268 binding surface 324602011269 TPR motif; other site 324602011270 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324602011271 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324602011272 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602011273 binding surface 324602011274 TPR motif; other site 324602011275 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324602011276 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324602011277 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602011278 binding surface 324602011279 TPR motif; other site 324602011280 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324602011281 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324602011282 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324602011283 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602011284 binding surface 324602011285 TPR motif; other site 324602011286 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324602011287 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324602011288 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602011289 binding surface 324602011290 TPR motif; other site 324602011291 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324602011292 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 324602011293 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 324602011294 sec-independent translocase; Provisional; Region: PRK04654 324602011295 acyl carrier protein; Provisional; Region: acpP; PRK00982 324602011296 transcription antitermination factor NusB; Region: nusB; TIGR01951 324602011297 putative RNA binding site [nucleotide binding]; other site 324602011298 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 324602011299 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 324602011300 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 324602011301 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 324602011302 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 324602011303 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 324602011304 NAD(P) binding site [chemical binding]; other site 324602011305 homotetramer interface [polypeptide binding]; other site 324602011306 homodimer interface [polypeptide binding]; other site 324602011307 active site 324602011308 Restriction endonuclease; Region: Mrr_cat; pfam04471 324602011309 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 324602011310 ATP cone domain; Region: ATP-cone; pfam03477 324602011311 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 324602011312 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483 324602011313 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 324602011314 Zn2+ binding site [ion binding]; other site 324602011315 Mg2+ binding site [ion binding]; other site 324602011316 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 324602011317 putative active site [active] 324602011318 Tocopherol phytyltransferase; Region: PT_UbiA_HPT1; cd13960 324602011319 putative active site [active] 324602011320 FOG: CBS domain [General function prediction only]; Region: COG0517 324602011321 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 324602011322 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324602011323 Histidine kinase; Region: HisKA_3; pfam07730 324602011324 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602011325 ATP binding site [chemical binding]; other site 324602011326 Mg2+ binding site [ion binding]; other site 324602011327 G-X-G motif; other site 324602011328 Predicted membrane protein [Function unknown]; Region: COG2311 324602011329 Protein of unknown function (DUF418); Region: DUF418; pfam04235 324602011330 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 324602011331 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602011332 active site 324602011333 phosphorylation site [posttranslational modification] 324602011334 intermolecular recognition site; other site 324602011335 dimerization interface [polypeptide binding]; other site 324602011336 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 324602011337 DNA binding residues [nucleotide binding] 324602011338 dimerization interface [polypeptide binding]; other site 324602011339 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 324602011340 putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK05641 324602011341 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 324602011342 carboxyltransferase (CT) interaction site; other site 324602011343 biotinylation site [posttranslational modification]; other site 324602011344 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 324602011345 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 324602011346 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 324602011347 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 324602011348 CAAX protease self-immunity; Region: Abi; pfam02517 324602011349 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 324602011350 active site 324602011351 Zn binding site [ion binding]; other site 324602011352 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 324602011353 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 324602011354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602011355 S-adenosylmethionine binding site [chemical binding]; other site 324602011356 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 324602011357 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 324602011358 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 324602011359 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602011360 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324602011361 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602011362 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324602011363 putative cation:proton antiport protein; Provisional; Region: PRK10669 324602011364 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 324602011365 TrkA-N domain; Region: TrkA_N; pfam02254 324602011366 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 324602011367 TrkA-C domain; Region: TrkA_C; pfam02080 324602011368 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 324602011369 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 324602011370 KIAA1161 is an uncharacterized Homo sapiens protein with a glycosyl hydrolase family 31 (GH31) domain that is homologous to the Escherichia coli YihQ glucosidase. Orthologs of KIA1161 are found in eukaryotes and prokaryotes. In bacteria, YihQ (along with...; Region: GH31_glucosidase_KIAA1161; cd06592 324602011371 putative active site [active] 324602011372 putative catalytic site [active] 324602011373 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324602011374 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324602011375 DNA binding site [nucleotide binding] 324602011376 domain linker motif; other site 324602011377 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324602011378 dimerization interface [polypeptide binding]; other site 324602011379 ligand binding site [chemical binding]; other site 324602011380 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 324602011381 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 324602011382 Walker A/P-loop; other site 324602011383 ATP binding site [chemical binding]; other site 324602011384 Q-loop/lid; other site 324602011385 ABC transporter signature motif; other site 324602011386 Walker B; other site 324602011387 D-loop; other site 324602011388 H-loop/switch region; other site 324602011389 TOBE domain; Region: TOBE; pfam03459 324602011390 TOBE domain; Region: TOBE; pfam03459 324602011391 Bpu10I restriction endonuclease; Region: RE_Bpu10I; pfam09549 324602011392 Methyltransferase domain; Region: Methyltransf_26; pfam13659 324602011393 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 324602011394 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 324602011395 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl19935 324602011396 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 324602011397 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324602011398 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602011399 TPR motif; other site 324602011400 binding surface 324602011401 AAA ATPase domain; Region: AAA_16; pfam13191 324602011402 CHAT domain; Region: CHAT; cl19248 324602011403 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 324602011404 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 324602011405 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324602011406 dimerization interface [polypeptide binding]; other site 324602011407 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 324602011408 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 324602011409 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 324602011410 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 324602011411 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 324602011412 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602011413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602011414 active site 324602011415 phosphorylation site [posttranslational modification] 324602011416 intermolecular recognition site; other site 324602011417 dimerization interface [polypeptide binding]; other site 324602011418 Helix-turn-helix domain; Region: HTH_25; pfam13413 324602011419 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 324602011420 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 324602011421 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 324602011422 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 324602011423 active site 324602011424 HIGH motif; other site 324602011425 KMSKS motif; other site 324602011426 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 324602011427 tRNA binding surface [nucleotide binding]; other site 324602011428 anticodon binding site; other site 324602011429 TQO small subunit DoxD; Region: DoxD; pfam04173 324602011430 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 324602011431 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 324602011432 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 324602011433 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 324602011434 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 324602011435 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 324602011436 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 324602011437 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 324602011438 catalytic loop [active] 324602011439 iron binding site [ion binding]; other site 324602011440 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 324602011441 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 324602011442 putative hydrophobic ligand binding site [chemical binding]; other site 324602011443 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 324602011444 homodimer interface [polypeptide binding]; other site 324602011445 substrate-cofactor binding pocket; other site 324602011446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602011447 catalytic residue [active] 324602011448 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 324602011449 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 324602011450 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324602011451 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602011452 dimer interface [polypeptide binding]; other site 324602011453 phosphorylation site [posttranslational modification] 324602011454 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602011455 ATP binding site [chemical binding]; other site 324602011456 Mg2+ binding site [ion binding]; other site 324602011457 G-X-G motif; other site 324602011458 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 324602011459 putative deacylase active site [active] 324602011460 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602011461 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 324602011462 hypothetical protein; Provisional; Region: PRK08317 324602011463 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602011464 S-adenosylmethionine binding site [chemical binding]; other site 324602011465 TPR repeat; Region: TPR_11; pfam13414 324602011466 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602011467 binding surface 324602011468 TPR motif; other site 324602011469 B-box zinc finger; Region: zf-B_box; pfam00643 324602011470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602011471 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 324602011472 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 324602011473 Walker A motif; other site 324602011474 ATP binding site [chemical binding]; other site 324602011475 Walker B motif; other site 324602011476 arginine finger; other site 324602011477 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 324602011478 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 324602011479 Predicted transcriptional regulator [Transcription]; Region: COG2345 324602011480 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 324602011481 putative Zn2+ binding site [ion binding]; other site 324602011482 putative DNA binding site [nucleotide binding]; other site 324602011483 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 324602011484 FeS assembly ATPase SufC; Region: sufC; TIGR01978 324602011485 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 324602011486 Walker A/P-loop; other site 324602011487 ATP binding site [chemical binding]; other site 324602011488 Q-loop/lid; other site 324602011489 ABC transporter signature motif; other site 324602011490 Walker B; other site 324602011491 D-loop; other site 324602011492 H-loop/switch region; other site 324602011493 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 324602011494 FeS assembly protein SufD; Region: sufD; TIGR01981 324602011495 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 324602011496 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 324602011497 catalytic residue [active] 324602011498 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 324602011499 trimerization site [polypeptide binding]; other site 324602011500 active site 324602011501 FeS assembly protein SufB; Region: sufB; TIGR01980 324602011502 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 324602011503 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 324602011504 [2Fe-2S] cluster binding site [ion binding]; other site 324602011505 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 324602011506 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 324602011507 active site residue [active] 324602011508 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 324602011509 active site residue [active] 324602011510 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 324602011511 trimerization site [polypeptide binding]; other site 324602011512 active site 324602011513 cysteine synthase; Region: PLN02565 324602011514 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 324602011515 dimer interface [polypeptide binding]; other site 324602011516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602011517 catalytic residue [active] 324602011518 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 324602011519 MPN+ (JAMM) motif; other site 324602011520 Zinc-binding site [ion binding]; other site 324602011521 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 324602011522 MoaE interaction surface [polypeptide binding]; other site 324602011523 MoeB interaction surface [polypeptide binding]; other site 324602011524 thiocarboxylated glycine; other site 324602011525 hypothetical protein; Validated; Region: PRK07411 324602011526 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 324602011527 ATP binding site [chemical binding]; other site 324602011528 substrate interface [chemical binding]; other site 324602011529 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: PspE; COG0607 324602011530 active site residue [active] 324602011531 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324602011532 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324602011533 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324602011534 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324602011535 dimerization interface [polypeptide binding]; other site 324602011536 putative DNA binding site [nucleotide binding]; other site 324602011537 putative Zn2+ binding site [ion binding]; other site 324602011538 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 324602011539 active site 324602011540 NTP binding site [chemical binding]; other site 324602011541 metal binding triad [ion binding]; metal-binding site 324602011542 antibiotic binding site [chemical binding]; other site 324602011543 CpXC protein; Region: CpXC; pfam14353 324602011544 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 324602011545 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 324602011546 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 324602011547 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 324602011548 lipoyl attachment site [posttranslational modification]; other site 324602011549 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 324602011550 tetramer interface [polypeptide binding]; other site 324602011551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602011552 catalytic residue [active] 324602011553 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 324602011554 active site 324602011555 substrate binding site [chemical binding]; other site 324602011556 Phosphotransferase enzyme family; Region: APH; pfam01636 324602011557 ATP binding site [chemical binding]; other site 324602011558 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 324602011559 tetramer interface [polypeptide binding]; other site 324602011560 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602011561 catalytic residue [active] 324602011562 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 324602011563 putative acyl-acceptor binding pocket; other site 324602011564 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 324602011565 PAS domain S-box; Region: sensory_box; TIGR00229 324602011566 PAS domain; Region: PAS; smart00091 324602011567 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324602011568 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602011569 dimer interface [polypeptide binding]; other site 324602011570 phosphorylation site [posttranslational modification] 324602011571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602011572 ATP binding site [chemical binding]; other site 324602011573 Mg2+ binding site [ion binding]; other site 324602011574 G-X-G motif; other site 324602011575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602011576 active site 324602011577 phosphorylation site [posttranslational modification] 324602011578 intermolecular recognition site; other site 324602011579 dimerization interface [polypeptide binding]; other site 324602011580 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 324602011581 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 324602011582 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 324602011583 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 324602011584 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 324602011585 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 324602011586 DNA photolyase; Region: DNA_photolyase; pfam00875 324602011587 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 324602011588 Aspartyl protease; Region: Asp_protease_2; pfam13650 324602011589 inhibitor binding site; inhibition site 324602011590 catalytic motif [active] 324602011591 Catalytic residue [active] 324602011592 Active site flap [active] 324602011593 Aspartyl protease; Region: Asp_protease_2; pfam13650 324602011594 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 324602011595 CHAT domain; Region: CHAT; cl19248 324602011596 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 324602011597 active site 324602011598 NTP binding site [chemical binding]; other site 324602011599 metal binding triad [ion binding]; metal-binding site 324602011600 antibiotic binding site [chemical binding]; other site 324602011601 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 324602011602 active site 324602011603 NTP binding site [chemical binding]; other site 324602011604 metal binding triad [ion binding]; metal-binding site 324602011605 antibiotic binding site [chemical binding]; other site 324602011606 ASRGL1_like domains, a subfamily of the L-Asparaginase type 2-like enzymes. The wider family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. The proenzymes undergo autoproteolytic cleavage before a threonine to generate alpha...; Region: ASRGL1_like; cd04702 324602011607 catalytic nucleophile [active] 324602011608 benzoate transport; Region: 2A0115; TIGR00895 324602011609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602011610 putative substrate translocation pore; other site 324602011611 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 324602011612 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 324602011613 GAF domain; Region: GAF; pfam01590 324602011614 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324602011615 metal binding site [ion binding]; metal-binding site 324602011616 active site 324602011617 I-site; other site 324602011618 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 324602011619 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 324602011620 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 324602011621 P-loop; other site 324602011622 Magnesium ion binding site [ion binding]; other site 324602011623 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 324602011624 Nucleoporin complex subunit 54; Region: Nup54; pfam13874 324602011625 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 324602011626 Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449 324602011627 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 324602011628 cyclase homology domain; Region: CHD; cd07302 324602011629 nucleotidyl binding site; other site 324602011630 metal binding site [ion binding]; metal-binding site 324602011631 dimer interface [polypeptide binding]; other site 324602011632 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 324602011633 ApbE family; Region: ApbE; pfam02424 324602011634 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 324602011635 Haem-binding domain; Region: Haem_bd; pfam14376 324602011636 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602011637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602011638 active site 324602011639 phosphorylation site [posttranslational modification] 324602011640 intermolecular recognition site; other site 324602011641 dimerization interface [polypeptide binding]; other site 324602011642 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324602011643 DNA binding site [nucleotide binding] 324602011644 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 324602011645 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602011646 dimer interface [polypeptide binding]; other site 324602011647 phosphorylation site [posttranslational modification] 324602011648 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602011649 ATP binding site [chemical binding]; other site 324602011650 Mg2+ binding site [ion binding]; other site 324602011651 G-X-G motif; other site 324602011652 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 324602011653 active site 324602011654 Ca binding site [ion binding]; other site 324602011655 catalytic site [active] 324602011656 Aamy_C domain; Region: Aamy_C; smart00632 324602011657 Alpha-amylase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. This domain is found in several bacterial and fungal alpha-amylases including the maltopentaose-forming amylases (G5-amylases). Most alpha-amylases have, in addition to the...; Region: CBM20_alpha_amylase; cd05808 324602011658 starch-binding site 2 [chemical binding]; other site 324602011659 starch-binding site 1 [chemical binding]; other site 324602011660 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 324602011661 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 324602011662 dimer interface [polypeptide binding]; other site 324602011663 active site 324602011664 CoA binding pocket [chemical binding]; other site 324602011665 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 324602011666 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324602011667 NAD(P) binding site [chemical binding]; other site 324602011668 active site 324602011669 peptide synthase; Provisional; Region: PRK09274 324602011670 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910 324602011671 acyl-activating enzyme (AAE) consensus motif; other site 324602011672 putative AMP binding site [chemical binding]; other site 324602011673 putative active site [active] 324602011674 putative CoA binding site [chemical binding]; other site 324602011675 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 324602011676 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 324602011677 haloalkane dehalogenase; Provisional; Region: PRK03592 324602011678 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 324602011679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602011680 active site 324602011681 phosphorylation site [posttranslational modification] 324602011682 intermolecular recognition site; other site 324602011683 dimerization interface [polypeptide binding]; other site 324602011684 PAS domain S-box; Region: sensory_box; TIGR00229 324602011685 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602011686 putative active site [active] 324602011687 heme pocket [chemical binding]; other site 324602011688 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324602011689 metal binding site [ion binding]; metal-binding site 324602011690 active site 324602011691 I-site; other site 324602011692 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 324602011693 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602011694 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602011695 active site 324602011696 phosphorylation site [posttranslational modification] 324602011697 intermolecular recognition site; other site 324602011698 dimerization interface [polypeptide binding]; other site 324602011699 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 324602011700 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 324602011701 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602011702 putative active site [active] 324602011703 heme pocket [chemical binding]; other site 324602011704 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 324602011705 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602011706 putative active site [active] 324602011707 heme pocket [chemical binding]; other site 324602011708 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602011709 dimer interface [polypeptide binding]; other site 324602011710 phosphorylation site [posttranslational modification] 324602011711 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602011712 ATP binding site [chemical binding]; other site 324602011713 Mg2+ binding site [ion binding]; other site 324602011714 G-X-G motif; other site 324602011715 translocation protein TolB; Provisional; Region: tolB; PRK00178 324602011716 FAD binding domain; Region: FAD_binding_4; cl19922 324602011717 Protein of unknown function (DUF524); Region: DUF524; pfam04411 324602011718 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 324602011719 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 324602011720 oligomer interface [polypeptide binding]; other site 324602011721 metal binding site [ion binding]; metal-binding site 324602011722 metal binding site [ion binding]; metal-binding site 324602011723 putative Cl binding site [ion binding]; other site 324602011724 aspartate ring; other site 324602011725 basic sphincter; other site 324602011726 hydrophobic gate; other site 324602011727 periplasmic entrance; other site 324602011728 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 324602011729 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 324602011730 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 324602011731 active site 324602011732 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 324602011733 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 324602011734 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 324602011735 argininosuccinate synthase; Validated; Region: PRK05370 324602011736 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 324602011737 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 324602011738 Ligand binding site [chemical binding]; other site 324602011739 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 324602011740 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 324602011741 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 324602011742 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; cl19645 324602011743 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 324602011744 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 324602011745 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324602011746 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 324602011747 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 324602011748 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 324602011749 putative active site [active] 324602011750 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 324602011751 Protein of unknown function, DUF488; Region: DUF488; pfam04343 324602011752 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 324602011753 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 324602011754 Probable Catalytic site; other site 324602011755 metal-binding site 324602011756 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 324602011757 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 324602011758 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 324602011759 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 324602011760 acyl-coenzyme A oxidase; Region: PLN02526 324602011761 active site 324602011762 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 324602011763 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 324602011764 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 324602011765 Divergent AAA domain; Region: AAA_4; pfam04326 324602011766 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 324602011767 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 324602011768 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 324602011769 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 324602011770 enterobactin exporter EntS; Provisional; Region: PRK10489 324602011771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602011772 putative substrate translocation pore; other site 324602011773 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 324602011774 dimer interface [polypeptide binding]; other site 324602011775 catalytic triad [active] 324602011776 peroxidatic and resolving cysteines [active] 324602011777 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 324602011778 rRNA interaction site [nucleotide binding]; other site 324602011779 S8 interaction site; other site 324602011780 putative laminin-1 binding site; other site 324602011781 elongation factor Ts; Reviewed; Region: tsf; PRK12332 324602011782 UBA/TS-N domain; Region: UBA; pfam00627 324602011783 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 324602011784 putative nucleotide binding site [chemical binding]; other site 324602011785 uridine monophosphate binding site [chemical binding]; other site 324602011786 homohexameric interface [polypeptide binding]; other site 324602011787 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 324602011788 hinge region; other site 324602011789 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 324602011790 active site 324602011791 dimer interface [polypeptide binding]; other site 324602011792 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 324602011793 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 324602011794 Putative lysophospholipase; Region: Hydrolase_4; cl19140 324602011795 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 324602011796 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 324602011797 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 324602011798 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 324602011799 RIP metalloprotease RseP; Region: TIGR00054 324602011800 active site 324602011801 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 324602011802 protein binding site [polypeptide binding]; other site 324602011803 putative substrate binding region [chemical binding]; other site 324602011804 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 324602011805 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 324602011806 BioY family; Region: BioY; pfam02632 324602011807 Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with rhodanese-like domains found N-terminal of the metallo-beta-lactamase domain; Region: RHOD_Lact_B; cd01523 324602011808 active site residue [active] 324602011809 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 324602011810 carboxylate-amine ligase; Provisional; Region: PRK13515 324602011811 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 324602011812 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 324602011813 FAD binding site [chemical binding]; other site 324602011814 homotetramer interface [polypeptide binding]; other site 324602011815 substrate binding pocket [chemical binding]; other site 324602011816 catalytic base [active] 324602011817 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 324602011818 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 324602011819 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 324602011820 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324602011821 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 324602011822 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324602011823 DNA binding residues [nucleotide binding] 324602011824 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 324602011825 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 324602011826 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 324602011827 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324602011828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602011829 putative substrate translocation pore; other site 324602011830 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 324602011831 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 324602011832 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 324602011833 dimerization interface [polypeptide binding]; other site 324602011834 putative DNA binding site [nucleotide binding]; other site 324602011835 putative Zn2+ binding site [ion binding]; other site 324602011836 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 324602011837 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 324602011838 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 324602011839 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324602011840 dimerization interface [polypeptide binding]; other site 324602011841 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602011842 dimer interface [polypeptide binding]; other site 324602011843 phosphorylation site [posttranslational modification] 324602011844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602011845 ATP binding site [chemical binding]; other site 324602011846 Mg2+ binding site [ion binding]; other site 324602011847 G-X-G motif; other site 324602011848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602011849 active site 324602011850 phosphorylation site [posttranslational modification] 324602011851 intermolecular recognition site; other site 324602011852 dimerization interface [polypeptide binding]; other site 324602011853 Trm112p-like protein; Region: Trm112p; pfam03966 324602011854 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602011855 S-adenosylmethionine binding site [chemical binding]; other site 324602011856 acylphosphatase; Provisional; Region: PRK14444 324602011857 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 324602011858 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 324602011859 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 324602011860 ligand binding site [chemical binding]; other site 324602011861 flexible hinge region; other site 324602011862 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 324602011863 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 324602011864 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 324602011865 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 324602011866 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 324602011867 active site 324602011868 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 324602011869 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 324602011870 AAA ATPase domain; Region: AAA_16; pfam13191 324602011871 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 324602011872 Ligand Binding Site [chemical binding]; other site 324602011873 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 324602011874 Ligand Binding Site [chemical binding]; other site 324602011875 hypothetical protein; Reviewed; Region: PRK00024 324602011876 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 324602011877 MPN+ (JAMM) motif; other site 324602011878 Zinc-binding site [ion binding]; other site 324602011879 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 324602011880 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 324602011881 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324602011882 active site 324602011883 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 324602011884 HIT family signature motif; other site 324602011885 catalytic residue [active] 324602011886 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 324602011887 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 324602011888 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 324602011889 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 324602011890 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 324602011891 Walker A/P-loop; other site 324602011892 ATP binding site [chemical binding]; other site 324602011893 Q-loop/lid; other site 324602011894 ABC transporter signature motif; other site 324602011895 Walker B; other site 324602011896 D-loop; other site 324602011897 H-loop/switch region; other site 324602011898 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 324602011899 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 324602011900 TrkA-N domain; Region: TrkA_N; pfam02254 324602011901 TrkA-C domain; Region: TrkA_C; pfam02080 324602011902 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 324602011903 putative FMN binding site [chemical binding]; other site 324602011904 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 324602011905 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 324602011906 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 324602011907 CAAX protease self-immunity; Region: Abi; pfam02517 324602011908 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 324602011909 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324602011910 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602011911 binding surface 324602011912 TPR motif; other site 324602011913 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324602011914 Bacterial transcriptional activator domain; Region: BTAD; smart01043 324602011915 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602011916 binding surface 324602011917 TPR motif; other site 324602011918 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 324602011919 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 324602011920 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 324602011921 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 324602011922 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 324602011923 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 324602011924 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 324602011925 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 324602011926 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 324602011927 acyl-activating enzyme (AAE) consensus motif; other site 324602011928 putative AMP binding site [chemical binding]; other site 324602011929 putative active site [active] 324602011930 putative CoA binding site [chemical binding]; other site 324602011931 PGAP1-like protein; Region: PGAP1; pfam07819 324602011932 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324602011933 Putative lysophospholipase; Region: Hydrolase_4; cl19140 324602011934 Putative lysophospholipase; Region: Hydrolase_4; cl19140 324602011935 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324602011936 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 324602011937 catalytic site [active] 324602011938 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 324602011939 dimer interaction site [polypeptide binding]; other site 324602011940 substrate-binding tunnel; other site 324602011941 active site 324602011942 catalytic site [active] 324602011943 substrate binding site [chemical binding]; other site 324602011944 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 324602011945 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 324602011946 substrate binding site [chemical binding]; other site 324602011947 oxyanion hole (OAH) forming residues; other site 324602011948 trimer interface [polypeptide binding]; other site 324602011949 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 324602011950 active site 2 [active] 324602011951 active site 1 [active] 324602011952 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 324602011953 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 324602011954 putative ligand binding site [chemical binding]; other site 324602011955 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 324602011956 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 324602011957 Walker A/P-loop; other site 324602011958 ATP binding site [chemical binding]; other site 324602011959 Q-loop/lid; other site 324602011960 ABC transporter signature motif; other site 324602011961 Walker B; other site 324602011962 D-loop; other site 324602011963 H-loop/switch region; other site 324602011964 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 324602011965 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 324602011966 Walker A/P-loop; other site 324602011967 ATP binding site [chemical binding]; other site 324602011968 Q-loop/lid; other site 324602011969 ABC transporter signature motif; other site 324602011970 Walker B; other site 324602011971 D-loop; other site 324602011972 H-loop/switch region; other site 324602011973 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 324602011974 TM-ABC transporter signature motif; other site 324602011975 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 324602011976 TM-ABC transporter signature motif; other site 324602011977 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 324602011978 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 324602011979 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 324602011980 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 324602011981 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602011982 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602011983 intermolecular recognition site; other site 324602011984 active site 324602011985 dimerization interface [polypeptide binding]; other site 324602011986 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 324602011987 DNA binding site [nucleotide binding] 324602011988 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 324602011989 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 324602011990 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602011991 S-adenosylmethionine binding site [chemical binding]; other site 324602011992 Asparaginase; Region: Asparaginase; pfam00710 324602011993 active site 324602011994 homodimer interface [polypeptide binding]; other site 324602011995 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 324602011996 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 324602011997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602011998 S-adenosylmethionine binding site [chemical binding]; other site 324602011999 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 324602012000 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 324602012001 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 324602012002 Ligand binding site; other site 324602012003 Putative Catalytic site; other site 324602012004 DXD motif; other site 324602012005 conserved hypothetical integral membrane protein; Region: TIGR03766 324602012006 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 324602012007 Tetratricopeptide repeat; Region: TPR_19; pfam14559 324602012008 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 324602012009 HEAT repeats; Region: HEAT_2; pfam13646 324602012010 Gaa1-like, GPI transamidase component; Region: Gaa1; pfam04114 324602012011 Bacterial SH3 domain; Region: SH3_3; pfam08239 324602012012 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 324602012013 Flavoprotein; Region: Flavoprotein; cl19190 324602012014 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 324602012015 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 324602012016 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 324602012017 CoA binding domain; Region: CoA_binding; smart00881 324602012018 salicylate biosynthesis isochorismate synthase; Validated; Region: PRK07054 324602012019 chorismate binding enzyme; Region: Chorismate_bind; cl10555 324602012020 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 324602012021 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 324602012022 dimer interface [polypeptide binding]; other site 324602012023 tetramer interface [polypeptide binding]; other site 324602012024 PYR/PP interface [polypeptide binding]; other site 324602012025 TPP binding site [chemical binding]; other site 324602012026 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 324602012027 TPP-binding site; other site 324602012028 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 324602012029 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 324602012030 inhibitor-cofactor binding pocket; inhibition site 324602012031 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602012032 catalytic residue [active] 324602012033 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 324602012034 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 324602012035 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 324602012036 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 324602012037 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 324602012038 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 324602012039 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 324602012040 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 324602012041 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 324602012042 E3 interaction surface; other site 324602012043 lipoyl attachment site [posttranslational modification]; other site 324602012044 e3 binding domain; Region: E3_binding; pfam02817 324602012045 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 324602012046 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 324602012047 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 324602012048 alpha subunit interface [polypeptide binding]; other site 324602012049 TPP binding site [chemical binding]; other site 324602012050 heterodimer interface [polypeptide binding]; other site 324602012051 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 324602012052 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 324602012053 tetramer interface [polypeptide binding]; other site 324602012054 TPP-binding site [chemical binding]; other site 324602012055 heterodimer interface [polypeptide binding]; other site 324602012056 phosphorylation loop region [posttranslational modification] 324602012057 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 324602012058 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 324602012059 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 324602012060 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324602012061 FeS/SAM binding site; other site 324602012062 bacteriochlorophyll 4-vinyl reductase; Region: BchJ; TIGR02019 324602012063 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 324602012064 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 324602012065 RNA binding surface [nucleotide binding]; other site 324602012066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602012067 S-adenosylmethionine binding site [chemical binding]; other site 324602012068 cobalt transport protein CbiM; Provisional; Region: PRK07331 324602012069 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 324602012070 PDGLE domain; Region: PDGLE; pfam13190 324602012071 Cobalt transport protein; Region: CbiQ; cl00463 324602012072 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 324602012073 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 324602012074 Walker A/P-loop; other site 324602012075 ATP binding site [chemical binding]; other site 324602012076 Q-loop/lid; other site 324602012077 ABC transporter signature motif; other site 324602012078 Walker B; other site 324602012079 D-loop; other site 324602012080 H-loop/switch region; other site 324602012081 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 324602012082 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_16; cd04674 324602012083 nudix motif; other site 324602012084 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 324602012085 catalytic residues [active] 324602012086 dimer interface [polypeptide binding]; other site 324602012087 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 324602012088 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 324602012089 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 324602012090 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 324602012091 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 324602012092 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 324602012093 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 324602012094 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 324602012095 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 324602012096 GIY-YIG type nucleases (URI domain); Region: GIYc; smart00465 324602012097 Immunity protein 14; Region: Imm14; pfam15428 324602012098 Immunity protein 14; Region: Imm14; pfam15428 324602012099 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 324602012100 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 324602012101 galactokinase; Provisional; Region: PRK05101 324602012102 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 324602012103 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 324602012104 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 324602012105 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 324602012106 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 324602012107 catalytic site [active] 324602012108 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 324602012109 FAD dependent oxidoreductase; Region: DAO; pfam01266 324602012110 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 324602012111 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 324602012112 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; cl19816 324602012113 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 324602012114 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 324602012115 Walker A/P-loop; other site 324602012116 ATP binding site [chemical binding]; other site 324602012117 Q-loop/lid; other site 324602012118 ABC transporter signature motif; other site 324602012119 Walker B; other site 324602012120 D-loop; other site 324602012121 H-loop/switch region; other site 324602012122 C-terminal AAA-associated domain; Region: AAA_assoc_C; pfam09821 324602012123 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 324602012124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602012125 dimer interface [polypeptide binding]; other site 324602012126 conserved gate region; other site 324602012127 putative PBP binding loops; other site 324602012128 ABC-ATPase subunit interface; other site 324602012129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602012130 dimer interface [polypeptide binding]; other site 324602012131 conserved gate region; other site 324602012132 putative PBP binding loops; other site 324602012133 ABC-ATPase subunit interface; other site 324602012134 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 324602012135 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 324602012136 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 324602012137 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 324602012138 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 324602012139 MgtE intracellular N domain; Region: MgtE_N; pfam03448 324602012140 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 324602012141 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 324602012142 Divalent cation transporter; Region: MgtE; pfam01769 324602012143 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 324602012144 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 324602012145 E3 interaction surface; other site 324602012146 lipoyl attachment site [posttranslational modification]; other site 324602012147 e3 binding domain; Region: E3_binding; pfam02817 324602012148 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 324602012149 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 324602012150 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 324602012151 TPP-binding site [chemical binding]; other site 324602012152 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 324602012153 dimer interface [polypeptide binding]; other site 324602012154 PYR/PP interface [polypeptide binding]; other site 324602012155 TPP binding site [chemical binding]; other site 324602012156 sec-independent translocase; Provisional; Region: PRK00708 324602012157 Speriolin N terminus; Region: Speriolin_N; pfam15058 324602012158 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 324602012159 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 324602012160 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 324602012161 Colicin V production protein; Region: Colicin_V; pfam02674 324602012162 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 324602012163 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 324602012164 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 324602012165 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 324602012166 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 324602012167 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 324602012168 homotrimer interaction site [polypeptide binding]; other site 324602012169 putative active site [active] 324602012170 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 324602012171 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 324602012172 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 324602012173 generic binding surface II; other site 324602012174 generic binding surface I; other site 324602012175 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 324602012176 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 324602012177 carboxyltransferase (CT) interaction site; other site 324602012178 biotinylation site [posttranslational modification]; other site 324602012179 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 324602012180 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 324602012181 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 324602012182 substrate binding pocket [chemical binding]; other site 324602012183 chain length determination region; other site 324602012184 substrate-Mg2+ binding site; other site 324602012185 catalytic residues [active] 324602012186 aspartate-rich region 1; other site 324602012187 active site lid residues [active] 324602012188 aspartate-rich region 2; other site 324602012189 RNA polymerase sigma factor; Provisional; Region: PRK12519 324602012190 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324602012191 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324602012192 DNA binding residues [nucleotide binding] 324602012193 M domain of GW182; Region: M_domain; pfam12938 324602012194 DDE superfamily endonuclease; Region: DDE_5; pfam13546 324602012195 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 324602012196 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 324602012197 Predicted transcriptional regulators [Transcription]; Region: COG1378 324602012198 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 324602012199 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 324602012200 C-terminal domain interface [polypeptide binding]; other site 324602012201 sugar binding site [chemical binding]; other site 324602012202 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 324602012203 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 324602012204 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 324602012205 Penicillin amidase; Region: Penicil_amidase; pfam01804 324602012206 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 324602012207 active site 324602012208 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 324602012209 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 324602012210 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 324602012211 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 324602012212 active site 324602012213 motif I; other site 324602012214 motif II; other site 324602012215 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 324602012216 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 324602012217 HlyD family secretion protein; Region: HlyD_3; pfam13437 324602012218 Proteobacterial lipase chaperone protein; Region: Lipase_chap; pfam03280 324602012219 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 324602012220 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 324602012221 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 324602012222 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 324602012223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 324602012224 S-adenosylmethionine binding site [chemical binding]; other site 324602012225 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 324602012226 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602012227 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324602012228 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 324602012229 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 324602012230 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602012231 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 324602012232 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 324602012233 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 324602012234 Probable Catalytic site; other site 324602012235 metal-binding site 324602012236 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 324602012237 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 324602012238 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324602012239 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 324602012240 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 324602012241 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 324602012242 Probable Catalytic site; other site 324602012243 metal-binding site 324602012244 Protein of unknown function (DUF3239); Region: DUF3239; pfam11580 324602012245 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 324602012246 BNR repeat-like domain; Region: BNR_2; pfam13088 324602012247 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 324602012248 Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250 324602012249 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 324602012250 Putative lysophospholipase; Region: Hydrolase_4; cl19140 324602012251 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 324602012252 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 324602012253 active site 324602012254 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 324602012255 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 324602012256 active site 324602012257 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 324602012258 active site 324602012259 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 324602012260 active site 324602012261 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 324602012262 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 324602012263 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 324602012264 Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077 324602012265 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 324602012266 classical (c) SDRs; Region: SDR_c; cd05233 324602012267 NAD(P) binding site [chemical binding]; other site 324602012268 active site 324602012269 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 324602012270 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 324602012271 acyl-activating enzyme (AAE) consensus motif; other site 324602012272 active site 324602012273 AMP binding site [chemical binding]; other site 324602012274 CoA binding site [chemical binding]; other site 324602012275 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u7; cd10931 324602012276 putative active site [active] 324602012277 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 324602012278 putative trimer interface [polypeptide binding]; other site 324602012279 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 324602012280 putative CoA binding site [chemical binding]; other site 324602012281 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 324602012282 trimer interface [polypeptide binding]; other site 324602012283 active site 324602012284 substrate binding site [chemical binding]; other site 324602012285 CoA binding site [chemical binding]; other site 324602012286 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 324602012287 active site 324602012288 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 324602012289 homodimer interface [polypeptide binding]; other site 324602012290 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 324602012291 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 324602012292 putative trimer interface [polypeptide binding]; other site 324602012293 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 324602012294 trimer interface [polypeptide binding]; other site 324602012295 active site 324602012296 substrate binding site [chemical binding]; other site 324602012297 putative CoA binding site [chemical binding]; other site 324602012298 CoA binding site [chemical binding]; other site 324602012299 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 324602012300 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 324602012301 Ligand binding site; other site 324602012302 Putative Catalytic site; other site 324602012303 DXD motif; other site 324602012304 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 324602012305 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 324602012306 B12 binding site [chemical binding]; other site 324602012307 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 324602012308 FeS/SAM binding site; other site 324602012309 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 324602012310 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 324602012311 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324602012312 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 324602012313 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 324602012314 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 324602012315 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 324602012316 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 324602012317 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 324602012318 Ligand binding site; other site 324602012319 Putative Catalytic site; other site 324602012320 DXD motif; other site 324602012321 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 324602012322 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 324602012323 dimer interface [polypeptide binding]; other site 324602012324 active site 324602012325 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 324602012326 inhibitor-cofactor binding pocket; inhibition site 324602012327 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602012328 catalytic residue [active] 324602012329 hypothetical protein; Provisional; Region: PRK07233 324602012330 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 324602012331 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 324602012332 CoA binding domain; Region: CoA_binding; cl17356 324602012333 Bacterial sugar transferase; Region: Bac_transf; pfam02397 324602012334 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 324602012335 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 324602012336 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 324602012337 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 324602012338 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 324602012339 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 324602012340 acyl-activating enzyme (AAE) consensus motif; other site 324602012341 putative AMP binding site [chemical binding]; other site 324602012342 putative active site [active] 324602012343 putative CoA binding site [chemical binding]; other site 324602012344 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 324602012345 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 324602012346 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 324602012347 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602012348 PAS domain; Region: PAS_9; pfam13426 324602012349 putative active site [active] 324602012350 heme pocket [chemical binding]; other site 324602012351 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602012352 PAS domain; Region: PAS_9; pfam13426 324602012353 putative active site [active] 324602012354 heme pocket [chemical binding]; other site 324602012355 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602012356 PAS domain; Region: PAS_9; pfam13426 324602012357 putative active site [active] 324602012358 heme pocket [chemical binding]; other site 324602012359 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 324602012360 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602012361 dimer interface [polypeptide binding]; other site 324602012362 phosphorylation site [posttranslational modification] 324602012363 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602012364 ATP binding site [chemical binding]; other site 324602012365 Mg2+ binding site [ion binding]; other site 324602012366 G-X-G motif; other site 324602012367 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602012368 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602012369 active site 324602012370 phosphorylation site [posttranslational modification] 324602012371 intermolecular recognition site; other site 324602012372 dimerization interface [polypeptide binding]; other site 324602012373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602012374 active site 324602012375 phosphorylation site [posttranslational modification] 324602012376 intermolecular recognition site; other site 324602012377 dimerization interface [polypeptide binding]; other site 324602012378 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602012379 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602012380 active site 324602012381 phosphorylation site [posttranslational modification] 324602012382 intermolecular recognition site; other site 324602012383 dimerization interface [polypeptide binding]; other site 324602012384 Hpt domain; Region: Hpt; pfam01627 324602012385 putative binding surface; other site 324602012386 active site 324602012387 response regulator PleD; Reviewed; Region: pleD; PRK09581 324602012388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602012389 active site 324602012390 phosphorylation site [posttranslational modification] 324602012391 intermolecular recognition site; other site 324602012392 dimerization interface [polypeptide binding]; other site 324602012393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602012394 active site 324602012395 phosphorylation site [posttranslational modification] 324602012396 intermolecular recognition site; other site 324602012397 dimerization interface [polypeptide binding]; other site 324602012398 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324602012399 metal binding site [ion binding]; metal-binding site 324602012400 active site 324602012401 I-site; other site 324602012402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078 324602012403 active site 324602012404 phosphorylation site [posttranslational modification] 324602012405 intermolecular recognition site; other site 324602012406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602012407 active site 324602012408 phosphorylation site [posttranslational modification] 324602012409 intermolecular recognition site; other site 324602012410 dimerization interface [polypeptide binding]; other site 324602012411 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 324602012412 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 324602012413 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 324602012414 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 324602012415 active site 324602012416 metal binding site [ion binding]; metal-binding site 324602012417 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 324602012418 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 324602012419 inhibitor-cofactor binding pocket; inhibition site 324602012420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602012421 catalytic residue [active] 324602012422 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 324602012423 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 324602012424 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 324602012425 active site 324602012426 DNA binding site [nucleotide binding] 324602012427 Int/Topo IB signature motif; other site 324602012428 Chlide_reductase_Y : Y subunit of chlorophyllide (chlide) reductase (BchY). Chlide reductase participates in photosynthetic pigment synthesis playing a role in the conversion of chlorophylls(Chl) into bacteriochlorophylls (BChl). Chlide reductase...; Region: Chlide_reductase_Y; cd01980 324602012429 Chlide_reductase_Z : Z subunit of chlorophyllide (chlide) reductase (BchZ). Chlide reductase participates in photosynthetic pigment synthesis playing a role in the conversion of chlorophylls(Chl) into bacteriochlorophylls (BChl). Chlide reductase...; Region: Chlide_reductase_Z; cd01982 324602012430 chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014 324602012431 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 324602012432 Survival protein SurE; Region: SurE; pfam01975 324602012433 enolase; Provisional; Region: eno; PRK00077 324602012434 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 324602012435 dimer interface [polypeptide binding]; other site 324602012436 metal binding site [ion binding]; metal-binding site 324602012437 substrate binding pocket [chemical binding]; other site 324602012438 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 324602012439 Chloroflexus aurantiacus (Ca) citrate synthase (CS)_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). This group is...; Region: CaCS_like; cd06116 324602012440 dimer interface [polypeptide binding]; other site 324602012441 active site 324602012442 citrylCoA binding site [chemical binding]; other site 324602012443 oxalacetate/citrate binding site [chemical binding]; other site 324602012444 coenzyme A binding site [chemical binding]; other site 324602012445 catalytic triad [active] 324602012446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602012447 putative substrate translocation pore; other site 324602012448 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324602012449 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 324602012450 putative active site [active] 324602012451 putative metal binding site [ion binding]; other site 324602012452 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 324602012453 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 324602012454 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 324602012455 phosphopeptide binding site; other site 324602012456 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 324602012457 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 324602012458 metal ion-dependent adhesion site (MIDAS); other site 324602012459 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 324602012460 active site 324602012461 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 324602012462 Catalytic domain of Protein Kinases; Region: PKc; cd00180 324602012463 active site 324602012464 ATP binding site [chemical binding]; other site 324602012465 substrate binding site [chemical binding]; other site 324602012466 activation loop (A-loop); other site 324602012467 FOG: WD40-like repeat [Function unknown]; Region: COG1520 324602012468 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 324602012469 active site 324602012470 Trp docking motif [polypeptide binding]; other site 324602012471 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 324602012472 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 324602012473 nucleotide binding site [chemical binding]; other site 324602012474 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 324602012475 Bacterial transcriptional activator domain; Region: BTAD; smart01043 324602012476 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 324602012477 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602012478 TPR motif; other site 324602012479 binding surface 324602012480 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324602012481 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324602012482 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602012483 binding surface 324602012484 TPR motif; other site 324602012485 Tetratricopeptide repeat; Region: TPR_12; pfam13424 324602012486 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602012487 binding surface 324602012488 TPR motif; other site 324602012489 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 324602012490 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 324602012491 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 324602012492 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 324602012493 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 324602012494 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 324602012495 Domain of unknown function DUF21; Region: DUF21; pfam01595 324602012496 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 324602012497 Transporter associated domain; Region: CorC_HlyC; smart01091 324602012498 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 324602012499 substrate binding site [chemical binding]; other site 324602012500 dimer interface [polypeptide binding]; other site 324602012501 catalytic triad [active] 324602012502 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 324602012503 Peptidase family M50; Region: Peptidase_M50; pfam02163 324602012504 active site 324602012505 putative substrate binding region [chemical binding]; other site 324602012506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602012507 Major Facilitator Superfamily; Region: MFS_1; pfam07690 324602012508 putative substrate translocation pore; other site 324602012509 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 324602012510 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 324602012511 siderophore binding site; other site 324602012512 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324602012513 ABC-ATPase subunit interface; other site 324602012514 dimer interface [polypeptide binding]; other site 324602012515 putative PBP binding regions; other site 324602012516 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 324602012517 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 324602012518 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 324602012519 ABC-ATPase subunit interface; other site 324602012520 dimer interface [polypeptide binding]; other site 324602012521 putative PBP binding regions; other site 324602012522 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 324602012523 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 324602012524 Walker A/P-loop; other site 324602012525 ATP binding site [chemical binding]; other site 324602012526 Q-loop/lid; other site 324602012527 ABC transporter signature motif; other site 324602012528 Walker B; other site 324602012529 D-loop; other site 324602012530 H-loop/switch region; other site 324602012531 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 324602012532 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 324602012533 intersubunit interface [polypeptide binding]; other site 324602012534 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 324602012535 photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042 324602012536 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 324602012537 siderophore binding site; other site 324602012538 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 324602012539 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 324602012540 siderophore binding site; other site 324602012541 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 324602012542 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 324602012543 active site 324602012544 catalytic tetrad [active] 324602012545 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; pfam10012 324602012546 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 324602012547 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 324602012548 catalytic Zn binding site [ion binding]; other site 324602012549 NAD(P) binding site [chemical binding]; other site 324602012550 structural Zn binding site [ion binding]; other site 324602012551 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 324602012552 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 324602012553 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 324602012554 primosome assembly protein PriA; Validated; Region: PRK05580 324602012555 Predicted transcriptional regulators [Transcription]; Region: ArsR; COG0640 324602012556 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 324602012557 ATP binding site [chemical binding]; other site 324602012558 putative Mg++ binding site [ion binding]; other site 324602012559 helicase superfamily c-terminal domain; Region: HELICc; smart00490 324602012560 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 324602012561 5S rRNA interface [nucleotide binding]; other site 324602012562 CTC domain interface [polypeptide binding]; other site 324602012563 L16 interface [polypeptide binding]; other site 324602012564 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 324602012565 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 324602012566 active site 324602012567 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 324602012568 acyl-coenzyme A oxidase; Region: PLN02526 324602012569 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 324602012570 active site 324602012571 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 324602012572 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 324602012573 motif 1; other site 324602012574 active site 324602012575 motif 2; other site 324602012576 motif 3; other site 324602012577 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 324602012578 large tegument protein UL36; Provisional; Region: PHA03247 324602012579 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 324602012580 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 324602012581 Coenzyme A binding pocket [chemical binding]; other site 324602012582 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 324602012583 Protein of unknown function (DUF507); Region: DUF507; cl01112 324602012584 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 324602012585 putative metal binding residues [ion binding]; other site 324602012586 signature motif; other site 324602012587 dimer interface [polypeptide binding]; other site 324602012588 active site 324602012589 polyP binding site; other site 324602012590 substrate binding site [chemical binding]; other site 324602012591 acceptor-phosphate pocket; other site 324602012592 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 324602012593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 324602012594 active site 324602012595 phosphorylation site [posttranslational modification] 324602012596 intermolecular recognition site; other site 324602012597 dimerization interface [polypeptide binding]; other site 324602012598 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 324602012599 DNA binding site [nucleotide binding] 324602012600 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324602012601 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324602012602 dimerization interface [polypeptide binding]; other site 324602012603 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602012604 dimer interface [polypeptide binding]; other site 324602012605 phosphorylation site [posttranslational modification] 324602012606 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602012607 ATP binding site [chemical binding]; other site 324602012608 Mg2+ binding site [ion binding]; other site 324602012609 G-X-G motif; other site 324602012610 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 324602012611 Putative carbohydrate binding domain; Region: CBM_X; pfam06204 324602012612 Glycoside hydrolase family 94 N-terminal-like domain of uncharacterized function; Region: GH94N_like_4; cd11751 324602012613 Amylo-alpha-1,6-glucosidase; Region: GDE_C; cl19168 324602012614 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324602012615 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 324602012616 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 324602012617 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 324602012618 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 324602012619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602012620 dimer interface [polypeptide binding]; other site 324602012621 conserved gate region; other site 324602012622 putative PBP binding loops; other site 324602012623 ABC-ATPase subunit interface; other site 324602012624 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324602012625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602012626 dimer interface [polypeptide binding]; other site 324602012627 conserved gate region; other site 324602012628 putative PBP binding loops; other site 324602012629 ABC-ATPase subunit interface; other site 324602012630 NHL repeat; Region: NHL; pfam01436 324602012631 Tetratricopeptide repeat; Region: TPR_16; pfam13432 324602012632 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 324602012633 TPR motif; other site 324602012634 binding surface 324602012635 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 324602012636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602012637 dimer interface [polypeptide binding]; other site 324602012638 conserved gate region; other site 324602012639 ABC-ATPase subunit interface; other site 324602012640 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 324602012641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 324602012642 dimer interface [polypeptide binding]; other site 324602012643 conserved gate region; other site 324602012644 putative PBP binding loops; other site 324602012645 ABC-ATPase subunit interface; other site 324602012646 Putative glucoamylase; Region: Glycoamylase; cl19893 324602012647 Transcriptional regulators [Transcription]; Region: PurR; COG1609 324602012648 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 324602012649 DNA binding site [nucleotide binding] 324602012650 domain linker motif; other site 324602012651 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 324602012652 dimerization interface [polypeptide binding]; other site 324602012653 ligand binding site [chemical binding]; other site 324602012654 Putative glucoamylase; Region: Glycoamylase; pfam10091 324602012655 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 324602012656 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 324602012657 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 324602012658 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 324602012659 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 324602012660 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 324602012661 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 324602012662 TM-ABC transporter signature motif; other site 324602012663 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 324602012664 TM-ABC transporter signature motif; other site 324602012665 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 324602012666 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 324602012667 Walker A/P-loop; other site 324602012668 ATP binding site [chemical binding]; other site 324602012669 Q-loop/lid; other site 324602012670 ABC transporter signature motif; other site 324602012671 Walker B; other site 324602012672 D-loop; other site 324602012673 H-loop/switch region; other site 324602012674 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324602012675 Walker A/P-loop; other site 324602012676 ATP binding site [chemical binding]; other site 324602012677 Q-loop/lid; other site 324602012678 ABC transporter signature motif; other site 324602012679 Walker B; other site 324602012680 D-loop; other site 324602012681 H-loop/switch region; other site 324602012682 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 324602012683 MG2 domain; Region: A2M_N; cl19929 324602012684 4-alpha-glucanotransferase; Provisional; Region: PRK14508 324602012685 recombination protein F; Reviewed; Region: recF; PRK00064 324602012686 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 324602012687 Walker A/P-loop; other site 324602012688 ATP binding site [chemical binding]; other site 324602012689 Q-loop/lid; other site 324602012690 ABC transporter signature motif; other site 324602012691 Walker B; other site 324602012692 D-loop; other site 324602012693 H-loop/switch region; other site 324602012694 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 324602012695 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 324602012696 homotetramer interface [polypeptide binding]; other site 324602012697 FMN binding site [chemical binding]; other site 324602012698 homodimer contacts [polypeptide binding]; other site 324602012699 putative active site [active] 324602012700 putative substrate binding site [chemical binding]; other site 324602012701 PAS domain S-box; Region: sensory_box; TIGR00229 324602012702 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602012703 putative active site [active] 324602012704 heme pocket [chemical binding]; other site 324602012705 PAS domain S-box; Region: sensory_box; TIGR00229 324602012706 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602012707 putative active site [active] 324602012708 heme pocket [chemical binding]; other site 324602012709 PAS fold; Region: PAS_4; pfam08448 324602012710 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 324602012711 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 324602012712 putative active site [active] 324602012713 FAD dependent oxidoreductase; Region: DAO; pfam01266 324602012714 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 324602012715 Beta-lactamase; Region: Beta-lactamase; pfam00144 324602012716 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 324602012717 Winged helix DNA-binding domain; Region: HTH_42; pfam06224 324602012718 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 324602012719 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 324602012720 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 324602012721 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 324602012722 putative active site [active] 324602012723 putative metal binding site [ion binding]; other site 324602012724 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 324602012725 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 324602012726 dimerization interface [polypeptide binding]; other site 324602012727 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 324602012728 dimer interface [polypeptide binding]; other site 324602012729 phosphorylation site [posttranslational modification] 324602012730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 324602012731 ATP binding site [chemical binding]; other site 324602012732 Mg2+ binding site [ion binding]; other site 324602012733 G-X-G motif; other site 324602012734 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 324602012735 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 324602012736 tetramer interface [polypeptide binding]; other site 324602012737 active site 324602012738 Mg2+/Mn2+ binding site [ion binding]; other site 324602012739 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 324602012740 homodimer interface [polypeptide binding]; other site 324602012741 chemical substrate binding site [chemical binding]; other site 324602012742 oligomer interface [polypeptide binding]; other site 324602012743 metal binding site [ion binding]; metal-binding site 324602012744 threonine dehydratase; Provisional; Region: PRK08198 324602012745 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 324602012746 tetramer interface [polypeptide binding]; other site 324602012747 pyridoxal 5'-phosphate binding site [chemical binding]; other site 324602012748 catalytic residue [active] 324602012749 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 324602012750 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 324602012751 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 324602012752 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 324602012753 Protein of unknown function (DUF1641); Region: DUF1641; pfam07849 324602012754 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 324602012755 Rhodanese-like domain; Region: Rhodanese; pfam00581 324602012756 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 324602012757 active site residue [active] 324602012758 Transcriptional regulator [Transcription]; Region: LysR; COG0583 324602012759 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 324602012760 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 324602012761 dimerization interface [polypeptide binding]; other site 324602012762 Putative zinc-finger; Region: zf-HC2; pfam13490 324602012763 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 324602012764 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324602012765 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 324602012766 DNA binding residues [nucleotide binding] 324602012767 Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO)-like family, N-terminal TRX-fold subdomain; composed of proteins with similarity to PfPDO, a redox active thermostable protein believed to be the archaeal counterpart of bacterial DsbA and...; Region: PfPDO_like_N; cd02975 324602012768 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 324602012769 catalytic residues [active] 324602012770 Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973 324602012771 catalytic residues [active] 324602012772 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 324602012773 putative substrate translocation pore; other site 324602012774 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 324602012775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 324602012776 TadE-like protein; Region: TadE; pfam07811 324602012777 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 324602012778 TadE-like protein; Region: TadE; pfam07811 324602012779 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 324602012780 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 324602012781 metal ion-dependent adhesion site (MIDAS); other site 324602012782 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 324602012783 AAA domain; Region: AAA_33; pfam13671 324602012784 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391 324602012785 AAA domain; Region: AAA_17; pfam13207 324602012786 active site 324602012787 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 324602012788 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 324602012789 putative trimer interface [polypeptide binding]; other site 324602012790 putative active site [active] 324602012791 putative substrate binding site [chemical binding]; other site 324602012792 putative CoA binding site [chemical binding]; other site 324602012793 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596 324602012794 active site 324602012795 Zn binding site [ion binding]; other site 324602012796 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 324602012797 Protein of unknown function DUF58; Region: DUF58; pfam01882 324602012798 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 324602012799 PAS domain; Region: PAS_8; pfam13188 324602012800 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 324602012801 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602012802 putative active site [active] 324602012803 heme pocket [chemical binding]; other site 324602012804 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 324602012805 putative active site [active] 324602012806 heme pocket [chemical binding]; other site 324602012807 GAF domain; Region: GAF_3; pfam13492 324602012808 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 324602012809 metal binding site [ion binding]; metal-binding site 324602012810 active site 324602012811 I-site; other site 324602012812 Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212 324602012813 Homocysteine S-methyltransferase; Region: S-methyl_trans; cl14105 324602012814 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 324602012815 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 324602012816 substrate binding pocket [chemical binding]; other site 324602012817 dimer interface [polypeptide binding]; other site 324602012818 inhibitor binding site; inhibition site 324602012819 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 324602012820 B12 binding site [chemical binding]; other site 324602012821 cobalt ligand [ion binding]; other site 324602012822 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 324602012823 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 324602012824 PhoU domain; Region: PhoU; pfam01895 324602012825 PhoU domain; Region: PhoU; pfam01895 324602012826 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 324602012827 catalytic triad [active] 324602012828 conserved cis-peptide bond; other site 324602012829 DNA topoisomerase I; Validated; Region: PRK06599 324602012830 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 324602012831 active site 324602012832 interdomain interaction site; other site 324602012833 putative metal-binding site [ion binding]; other site 324602012834 nucleotide binding site [chemical binding]; other site 324602012835 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 324602012836 domain I; other site 324602012837 DNA binding groove [nucleotide binding] 324602012838 phosphate binding site [ion binding]; other site 324602012839 domain II; other site 324602012840 domain III; other site 324602012841 nucleotide binding site [chemical binding]; other site 324602012842 catalytic site [active] 324602012843 domain IV; other site 324602012844 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 324602012845 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 324602012846 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 324602012847 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 324602012848 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 324602012849 Ferritin-like domain; Region: Ferritin; pfam00210 324602012850 ferroxidase diiron center [ion binding]; other site 324602012851 Protein of unknown function (DUF3623); Region: DUF3623; cl11843 324602012852 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 324602012853 CoA binding domain; Region: CoA_binding_2; pfam13380 324602012854 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 324602012855 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 324602012856 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 324602012857 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 324602012858 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 324602012859 DRTGG domain; Region: DRTGG; pfam07085 324602012860 laccase, plant; Region: laccase; TIGR03389 324602012861 transcription-repair coupling factor (mfd); Region: mfd; TIGR00580 324602012862 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 324602012863 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 324602012864 quinone interaction residues [chemical binding]; other site 324602012865 active site 324602012866 catalytic residues [active] 324602012867 FMN binding site [chemical binding]; other site 324602012868 substrate binding site [chemical binding]; other site 324602012869 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 324602012870 active site 324602012871 dimer interface [polypeptide binding]; other site 324602012872 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 324602012873 active site 324602012874 Yip1 domain; Region: Yip1; pfam04893 324602012875 Yip1 domain; Region: Yip1; pfam04893 324602012876 Protein of unknown function (DUF342); Region: DUF342; cl19219 324602012877 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 324602012878 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 324602012879 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 324602012880 DNA binding residues [nucleotide binding] 324602012881 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 324602012882 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 324602012883 TM-ABC transporter signature motif; other site 324602012884 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079