-- dump date 20140619_041607 -- class Genbank::misc_feature -- table misc_feature_note -- id note 517418000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 517418000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 517418000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 517418000004 Walker A motif; other site 517418000005 ATP binding site [chemical binding]; other site 517418000006 Walker B motif; other site 517418000007 arginine finger; other site 517418000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 517418000009 DnaA box-binding interface [nucleotide binding]; other site 517418000010 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 517418000011 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 517418000012 Walker A motif; other site 517418000013 ATP binding site [chemical binding]; other site 517418000014 Walker B motif; other site 517418000015 arginine finger; other site 517418000016 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 517418000017 DNA gyrase subunit A; Validated; Region: PRK05560 517418000018 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 517418000019 CAP-like domain; other site 517418000020 active site 517418000021 primary dimer interface [polypeptide binding]; other site 517418000022 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 517418000023 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 517418000024 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 517418000025 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 517418000026 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 517418000027 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 517418000028 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 517418000029 Walker A/P-loop; other site 517418000030 ATP binding site [chemical binding]; other site 517418000031 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 517418000032 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 517418000033 ABC transporter signature motif; other site 517418000034 Walker B; other site 517418000035 D-loop; other site 517418000036 H-loop/switch region; other site 517418000037 beta-D-glucuronidase; Provisional; Region: PRK10150 517418000038 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 517418000039 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 517418000040 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 517418000041 Yip1 domain; Region: Yip1; pfam04893 517418000042 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 517418000043 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 517418000044 CAAX protease self-immunity; Region: Abi; pfam02517 517418000045 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 517418000046 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 517418000047 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 517418000048 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 517418000049 active site 517418000050 phosphorylation site [posttranslational modification] 517418000051 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 517418000052 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 517418000053 dimer interface [polypeptide binding]; other site 517418000054 motif 1; other site 517418000055 active site 517418000056 motif 2; other site 517418000057 motif 3; other site 517418000058 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 517418000059 anticodon binding site; other site 517418000060 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 517418000061 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 517418000062 ligand binding site [chemical binding]; other site 517418000063 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 517418000064 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 517418000065 Walker A/P-loop; other site 517418000066 ATP binding site [chemical binding]; other site 517418000067 Q-loop/lid; other site 517418000068 ABC transporter signature motif; other site 517418000069 Walker B; other site 517418000070 D-loop; other site 517418000071 H-loop/switch region; other site 517418000072 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 517418000073 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 517418000074 HlyD family secretion protein; Region: HlyD_3; pfam13437 517418000075 Outer membrane efflux protein; Region: OEP; pfam02321 517418000076 Outer membrane efflux protein; Region: OEP; pfam02321 517418000077 Response regulator receiver domain; Region: Response_reg; pfam00072 517418000078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418000079 active site 517418000080 phosphorylation site [posttranslational modification] 517418000081 intermolecular recognition site; other site 517418000082 dimerization interface [polypeptide binding]; other site 517418000083 PAS domain; Region: PAS_9; pfam13426 517418000084 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418000085 putative active site [active] 517418000086 heme pocket [chemical binding]; other site 517418000087 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 517418000088 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 517418000089 dimer interface [polypeptide binding]; other site 517418000090 phosphorylation site [posttranslational modification] 517418000091 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418000092 ATP binding site [chemical binding]; other site 517418000093 Mg2+ binding site [ion binding]; other site 517418000094 G-X-G motif; other site 517418000095 Response regulator receiver domain; Region: Response_reg; pfam00072 517418000096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418000097 active site 517418000098 phosphorylation site [posttranslational modification] 517418000099 intermolecular recognition site; other site 517418000100 dimerization interface [polypeptide binding]; other site 517418000101 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 517418000102 putative binding surface; other site 517418000103 active site 517418000104 Response regulator receiver domain; Region: Response_reg; pfam00072 517418000105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418000106 active site 517418000107 phosphorylation site [posttranslational modification] 517418000108 intermolecular recognition site; other site 517418000109 dimerization interface [polypeptide binding]; other site 517418000110 PAS fold; Region: PAS_3; pfam08447 517418000111 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 517418000112 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 517418000113 PAS fold; Region: PAS; pfam00989 517418000114 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418000115 putative active site [active] 517418000116 heme pocket [chemical binding]; other site 517418000117 PAS fold; Region: PAS_3; pfam08447 517418000118 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418000119 putative active site [active] 517418000120 heme pocket [chemical binding]; other site 517418000121 PAS fold; Region: PAS_3; pfam08447 517418000122 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 517418000123 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418000124 putative active site [active] 517418000125 heme pocket [chemical binding]; other site 517418000126 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 517418000127 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418000128 putative active site [active] 517418000129 heme pocket [chemical binding]; other site 517418000130 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 517418000131 dimer interface [polypeptide binding]; other site 517418000132 phosphorylation site [posttranslational modification] 517418000133 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418000134 ATP binding site [chemical binding]; other site 517418000135 Mg2+ binding site [ion binding]; other site 517418000136 G-X-G motif; other site 517418000137 KWG Leptospira; Region: KWG; pfam07656 517418000138 KWG Leptospira; Region: KWG; pfam07656 517418000139 KWG Leptospira; Region: KWG; pfam07656 517418000140 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 517418000141 active site 517418000142 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 517418000143 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 517418000144 inhibitor-cofactor binding pocket; inhibition site 517418000145 pyridoxal 5'-phosphate binding site [chemical binding]; other site 517418000146 catalytic residue [active] 517418000147 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418000148 binding surface 517418000149 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418000150 TPR motif; other site 517418000151 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418000152 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418000153 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418000154 binding surface 517418000155 TPR motif; other site 517418000156 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418000157 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418000158 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 517418000159 metal binding site [ion binding]; metal-binding site 517418000160 active site 517418000161 I-site; other site 517418000162 membrane protein; Provisional; Region: PRK14410 517418000163 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 517418000164 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 517418000165 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 517418000166 hypothetical protein; Validated; Region: PRK07883 517418000167 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 517418000168 active site 517418000169 catalytic site [active] 517418000170 substrate binding site [chemical binding]; other site 517418000171 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 517418000172 GIY-YIG motif/motif A; other site 517418000173 active site 517418000174 catalytic site [active] 517418000175 putative DNA binding site [nucleotide binding]; other site 517418000176 metal binding site [ion binding]; metal-binding site 517418000177 Predicted methyltransferases [General function prediction only]; Region: COG0313 517418000178 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 517418000179 putative SAM binding site [chemical binding]; other site 517418000180 putative homodimer interface [polypeptide binding]; other site 517418000181 Pantoate-beta-alanine ligase; Region: PanC; cd00560 517418000182 pantoate--beta-alanine ligase; Region: panC; TIGR00018 517418000183 active site 517418000184 ATP-binding site [chemical binding]; other site 517418000185 pantoate-binding site; other site 517418000186 HXXH motif; other site 517418000187 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 517418000188 intersubunit interface [polypeptide binding]; other site 517418000189 active site 517418000190 Zn2+ binding site [ion binding]; other site 517418000191 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 517418000192 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 517418000193 Predicted integral membrane protein [Function unknown]; Region: COG5617 517418000194 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 517418000195 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 517418000196 active site 517418000197 DNA binding site [nucleotide binding] 517418000198 Int/Topo IB signature motif; other site 517418000199 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 517418000200 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 517418000201 catalytic residues [active] 517418000202 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 517418000203 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 517418000204 phosphoserine phosphatase SerB; Region: serB; TIGR00338 517418000205 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 517418000206 motif II; other site 517418000207 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 517418000208 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 517418000209 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 517418000210 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 517418000211 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 517418000212 putative Zn2+ binding site [ion binding]; other site 517418000213 putative DNA binding site [nucleotide binding]; other site 517418000214 AsnC family; Region: AsnC_trans_reg; pfam01037 517418000215 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 517418000216 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 517418000217 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 517418000218 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 517418000219 NAD binding site [chemical binding]; other site 517418000220 homodimer interface [polypeptide binding]; other site 517418000221 active site 517418000222 substrate binding site [chemical binding]; other site 517418000223 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 517418000224 MPN+ (JAMM) motif; other site 517418000225 Zinc-binding site [ion binding]; other site 517418000226 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 517418000227 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 517418000228 dimer interface [polypeptide binding]; other site 517418000229 pyridoxal 5'-phosphate binding site [chemical binding]; other site 517418000230 catalytic residue [active] 517418000231 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 517418000232 MPN+ (JAMM) motif; other site 517418000233 Zinc-binding site [ion binding]; other site 517418000234 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 517418000235 recombinase A; Provisional; Region: recA; PRK09354 517418000236 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 517418000237 hexamer interface [polypeptide binding]; other site 517418000238 Walker A motif; other site 517418000239 ATP binding site [chemical binding]; other site 517418000240 Walker B motif; other site 517418000241 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 517418000242 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 517418000243 putative catalytic residue [active] 517418000244 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 517418000245 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 517418000246 putative NADP binding site [chemical binding]; other site 517418000247 putative substrate binding site [chemical binding]; other site 517418000248 active site 517418000249 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 517418000250 carboxyltransferase (CT) interaction site; other site 517418000251 biotinylation site [posttranslational modification]; other site 517418000252 DnaJ domain; Region: DnaJ; pfam00226 517418000253 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 517418000254 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 517418000255 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 517418000256 chaperone protein DnaJ; Provisional; Region: PRK14299 517418000257 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 517418000258 HSP70 interaction site [polypeptide binding]; other site 517418000259 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 517418000260 substrate binding site [polypeptide binding]; other site 517418000261 dimer interface [polypeptide binding]; other site 517418000262 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 517418000263 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 517418000264 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 517418000265 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 517418000266 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 517418000267 ATP binding site [chemical binding]; other site 517418000268 putative Mg++ binding site [ion binding]; other site 517418000269 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 517418000270 nucleotide binding region [chemical binding]; other site 517418000271 ATP-binding site [chemical binding]; other site 517418000272 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 517418000273 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 517418000274 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 517418000275 Glycoprotease family; Region: Peptidase_M22; pfam00814 517418000276 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 517418000277 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 517418000278 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 517418000279 active site 517418000280 metal binding site [ion binding]; metal-binding site 517418000281 Radical SAM superfamily; Region: Radical_SAM; pfam04055 517418000282 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 517418000283 FeS/SAM binding site; other site 517418000284 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 517418000285 substrate binding site [chemical binding]; other site 517418000286 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 517418000287 FMN binding site [chemical binding]; other site 517418000288 dimer interface [polypeptide binding]; other site 517418000289 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 517418000290 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 517418000291 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 517418000292 motif II; other site 517418000293 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 517418000294 tetramer interface [polypeptide binding]; other site 517418000295 dimer interface [polypeptide binding]; other site 517418000296 circadian clock protein KaiC; Reviewed; Region: PRK09302 517418000297 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 517418000298 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 517418000299 Walker A motif; other site 517418000300 Walker A motif; other site 517418000301 ATP binding site [chemical binding]; other site 517418000302 Walker B motif; other site 517418000303 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 517418000304 Walker A motif; other site 517418000305 ATP binding site [chemical binding]; other site 517418000306 Walker B motif; other site 517418000307 Lamin Tail Domain; Region: LTD; pfam00932 517418000308 Lamin Tail Domain; Region: LTD; pfam00932 517418000309 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 517418000310 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 517418000311 RNA methyltransferase, RsmE family; Region: TIGR00046 517418000312 hypothetical protein; Provisional; Region: PRK04164 517418000313 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 517418000314 Coenzyme A binding pocket [chemical binding]; other site 517418000315 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 517418000316 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 517418000317 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 517418000318 FtsX-like permease family; Region: FtsX; pfam02687 517418000319 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 517418000320 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 517418000321 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 517418000322 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 517418000323 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 517418000324 S-adenosylmethionine binding site [chemical binding]; other site 517418000325 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 517418000326 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 517418000327 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 517418000328 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 517418000329 CAAX protease self-immunity; Region: Abi; pfam02517 517418000330 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 517418000331 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 517418000332 nucleotide binding pocket [chemical binding]; other site 517418000333 K-X-D-G motif; other site 517418000334 catalytic site [active] 517418000335 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 517418000336 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 517418000337 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 517418000338 Dimer interface [polypeptide binding]; other site 517418000339 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 517418000340 Competence protein; Region: Competence; pfam03772 517418000341 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 517418000342 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 517418000343 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 517418000344 putative active site [active] 517418000345 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 517418000346 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 517418000347 MutS domain I; Region: MutS_I; pfam01624 517418000348 MutS domain II; Region: MutS_II; pfam05188 517418000349 MutS domain III; Region: MutS_III; pfam05192 517418000350 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 517418000351 Walker A/P-loop; other site 517418000352 ATP binding site [chemical binding]; other site 517418000353 Q-loop/lid; other site 517418000354 ABC transporter signature motif; other site 517418000355 Walker B; other site 517418000356 D-loop; other site 517418000357 H-loop/switch region; other site 517418000358 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 517418000359 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 517418000360 malate dehydrogenase; Reviewed; Region: PRK06223 517418000361 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 517418000362 NAD(P) binding site [chemical binding]; other site 517418000363 dimer interface [polypeptide binding]; other site 517418000364 tetramer (dimer of dimers) interface [polypeptide binding]; other site 517418000365 substrate binding site [chemical binding]; other site 517418000366 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 517418000367 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 517418000368 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 517418000369 protein binding site [polypeptide binding]; other site 517418000370 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 517418000371 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 517418000372 substrate binding site [chemical binding]; other site 517418000373 glutamase interaction surface [polypeptide binding]; other site 517418000374 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 517418000375 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 517418000376 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 517418000377 Radical SAM superfamily; Region: Radical_SAM; pfam04055 517418000378 FeS/SAM binding site; other site 517418000379 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 517418000380 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cl00238 517418000381 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 517418000382 Zn binding site [ion binding]; other site 517418000383 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 517418000384 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 517418000385 putative dimer interface [polypeptide binding]; other site 517418000386 active site pocket [active] 517418000387 putative cataytic base [active] 517418000388 cobalamin synthase; Reviewed; Region: cobS; PRK00235 517418000389 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 517418000390 catalytic core [active] 517418000391 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 517418000392 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 517418000393 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 517418000394 FeS/SAM binding site; other site 517418000395 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 517418000396 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 517418000397 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 517418000398 cytidylate kinase; Provisional; Region: cmk; PRK00023 517418000399 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 517418000400 CMP-binding site; other site 517418000401 The sites determining sugar specificity; other site 517418000402 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 517418000403 LytB protein; Region: LYTB; cl00507 517418000404 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 517418000405 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 517418000406 RNA binding site [nucleotide binding]; other site 517418000407 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 517418000408 RNA binding site [nucleotide binding]; other site 517418000409 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 517418000410 RNA binding site [nucleotide binding]; other site 517418000411 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 517418000412 RNA binding site [nucleotide binding]; other site 517418000413 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 517418000414 RNA binding site [nucleotide binding]; other site 517418000415 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 517418000416 RNA binding site [nucleotide binding]; other site 517418000417 GTPase Era; Reviewed; Region: era; PRK00089 517418000418 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 517418000419 G1 box; other site 517418000420 GTP/Mg2+ binding site [chemical binding]; other site 517418000421 Switch I region; other site 517418000422 G2 box; other site 517418000423 Switch II region; other site 517418000424 G3 box; other site 517418000425 G4 box; other site 517418000426 G5 box; other site 517418000427 KH domain; Region: KH_2; pfam07650 517418000428 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 517418000429 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 517418000430 EamA-like transporter family; Region: EamA; pfam00892 517418000431 EamA-like transporter family; Region: EamA; pfam00892 517418000432 Domain of unknown function (DUF202); Region: DUF202; pfam02656 517418000433 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 517418000434 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 517418000435 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 517418000436 molybdopterin cofactor binding site; other site 517418000437 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 517418000438 putative molybdopterin cofactor binding site; other site 517418000439 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 517418000440 4Fe-4S binding domain; Region: Fer4; pfam00037 517418000441 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 517418000442 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 517418000443 FeS/SAM binding site; other site 517418000444 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 517418000445 Biotin synthase-related enzyme [General function prediction only]; Region: COG2516 517418000446 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 517418000447 FeS/SAM binding site; other site 517418000448 Uncharacterized homolog of biotin synthetase [Function unknown]; Region: COG1856 517418000449 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 517418000450 FeS/SAM binding site; other site 517418000451 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 517418000452 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 517418000453 lipoyl attachment site [posttranslational modification]; other site 517418000454 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 517418000455 Cysteine-rich domain; Region: CCG; pfam02754 517418000456 Cysteine-rich domain; Region: CCG; pfam02754 517418000457 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 517418000458 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 517418000459 Ligand binding site [chemical binding]; other site 517418000460 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 517418000461 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 517418000462 Ligand Binding Site [chemical binding]; other site 517418000463 Electron transfer flavoprotein domain; Region: ETF; pfam01012 517418000464 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 517418000465 Cysteine-rich domain; Region: CCG; pfam02754 517418000466 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 517418000467 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 517418000468 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 517418000469 Cysteine-rich domain; Region: CCG; pfam02754 517418000470 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 517418000471 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 517418000472 catalytic residues [active] 517418000473 glycine cleavage system protein H; Provisional; Region: PRK13380 517418000474 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 517418000475 lipoyl attachment site [posttranslational modification]; other site 517418000476 Predicted peroxiredoxins [General function prediction only]; Region: COG2044 517418000477 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14955 517418000478 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 517418000479 Walker A motif; other site 517418000480 ATP binding site [chemical binding]; other site 517418000481 Walker B motif; other site 517418000482 arginine finger; other site 517418000483 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 517418000484 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14954 517418000485 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 517418000486 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 517418000487 Cl binding site [ion binding]; other site 517418000488 oligomer interface [polypeptide binding]; other site 517418000489 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418000490 PAS fold; Region: PAS_3; pfam08447 517418000491 putative active site [active] 517418000492 heme pocket [chemical binding]; other site 517418000493 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418000494 PAS domain; Region: PAS_9; pfam13426 517418000495 putative active site [active] 517418000496 heme pocket [chemical binding]; other site 517418000497 PAS domain S-box; Region: sensory_box; TIGR00229 517418000498 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418000499 putative active site [active] 517418000500 heme pocket [chemical binding]; other site 517418000501 PAS domain S-box; Region: sensory_box; TIGR00229 517418000502 PAS domain; Region: PAS_8; pfam13188 517418000503 PAS domain S-box; Region: sensory_box; TIGR00229 517418000504 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418000505 putative active site [active] 517418000506 heme pocket [chemical binding]; other site 517418000507 PAS fold; Region: PAS_4; pfam08448 517418000508 PAS domain S-box; Region: sensory_box; TIGR00229 517418000509 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418000510 putative active site [active] 517418000511 heme pocket [chemical binding]; other site 517418000512 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 517418000513 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418000514 putative active site [active] 517418000515 heme pocket [chemical binding]; other site 517418000516 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418000517 putative active site [active] 517418000518 heme pocket [chemical binding]; other site 517418000519 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 517418000520 Histidine kinase; Region: HisKA_2; pfam07568 517418000521 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418000522 ATP binding site [chemical binding]; other site 517418000523 Mg2+ binding site [ion binding]; other site 517418000524 G-X-G motif; other site 517418000525 Response regulator receiver domain; Region: Response_reg; pfam00072 517418000526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418000527 active site 517418000528 phosphorylation site [posttranslational modification] 517418000529 intermolecular recognition site; other site 517418000530 dimerization interface [polypeptide binding]; other site 517418000531 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 517418000532 cyclase homology domain; Region: CHD; cd07302 517418000533 nucleotidyl binding site; other site 517418000534 metal binding site [ion binding]; metal-binding site 517418000535 dimer interface [polypeptide binding]; other site 517418000536 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 517418000537 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 517418000538 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 517418000539 MarR family; Region: MarR_2; pfam12802 517418000540 Uncharacterized conserved protein [Function unknown]; Region: COG2353 517418000541 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 517418000542 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 517418000543 active site 517418000544 ADP/pyrophosphate binding site [chemical binding]; other site 517418000545 dimerization interface [polypeptide binding]; other site 517418000546 allosteric effector site; other site 517418000547 fructose-1,6-bisphosphate binding site; other site 517418000548 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 517418000549 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 517418000550 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 517418000551 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 517418000552 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 517418000553 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 517418000554 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 517418000555 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 517418000556 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 517418000557 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 517418000558 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 517418000559 pyridoxal 5'-phosphate binding site [chemical binding]; other site 517418000560 homodimer interface [polypeptide binding]; other site 517418000561 catalytic residue [active] 517418000562 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 517418000563 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 517418000564 Ferritin-like domain; Region: Ferritin; pfam00210 517418000565 binuclear metal center [ion binding]; other site 517418000566 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 517418000567 iron binding site [ion binding]; other site 517418000568 Rubredoxin [Energy production and conversion]; Region: COG1773 517418000569 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 517418000570 iron binding site [ion binding]; other site 517418000571 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 517418000572 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 517418000573 active site 517418000574 FMN binding site [chemical binding]; other site 517418000575 substrate binding site [chemical binding]; other site 517418000576 3Fe-4S cluster binding site [ion binding]; other site 517418000577 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 517418000578 Cysteine-rich domain; Region: CCG; pfam02754 517418000579 Cysteine-rich domain; Region: CCG; pfam02754 517418000580 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 517418000581 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 517418000582 catalytic loop [active] 517418000583 iron binding site [ion binding]; other site 517418000584 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 517418000585 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 517418000586 catalytic loop [active] 517418000587 iron binding site [ion binding]; other site 517418000588 L-aspartate oxidase; Provisional; Region: PRK06175 517418000589 succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812 517418000590 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 517418000591 FOG: CBS domain [General function prediction only]; Region: COG0517 517418000592 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 517418000593 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 517418000594 Helix-hairpin-helix motif; Region: HHH; pfam00633 517418000595 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 517418000596 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 517418000597 active site 517418000598 dimer interface [polypeptide binding]; other site 517418000599 metal binding site [ion binding]; metal-binding site 517418000600 shikimate kinase; Reviewed; Region: aroK; PRK00131 517418000601 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 517418000602 ADP binding site [chemical binding]; other site 517418000603 magnesium binding site [ion binding]; other site 517418000604 putative shikimate binding site; other site 517418000605 OsmC-like protein; Region: OsmC; pfam02566 517418000606 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 517418000607 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 517418000608 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 517418000609 G1 box; other site 517418000610 GTP/Mg2+ binding site [chemical binding]; other site 517418000611 Switch I region; other site 517418000612 G2 box; other site 517418000613 G3 box; other site 517418000614 Switch II region; other site 517418000615 G4 box; other site 517418000616 G5 box; other site 517418000617 Nucleoside recognition; Region: Gate; pfam07670 517418000618 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 517418000619 Nucleoside recognition; Region: Gate; pfam07670 517418000620 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 517418000621 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 517418000622 TPP-binding site; other site 517418000623 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 517418000624 PYR/PP interface [polypeptide binding]; other site 517418000625 dimer interface [polypeptide binding]; other site 517418000626 TPP binding site [chemical binding]; other site 517418000627 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 517418000628 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 517418000629 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 517418000630 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 517418000631 carboxyltransferase (CT) interaction site; other site 517418000632 biotinylation site [posttranslational modification]; other site 517418000633 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 517418000634 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 517418000635 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 517418000636 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307 517418000637 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 517418000638 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 517418000639 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 517418000640 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 517418000641 DNA binding site [nucleotide binding] 517418000642 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 517418000643 active site 517418000644 HslU subunit interaction site [polypeptide binding]; other site 517418000645 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 517418000646 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 517418000647 Walker A motif; other site 517418000648 ATP binding site [chemical binding]; other site 517418000649 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 517418000650 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 517418000651 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 517418000652 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 517418000653 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 517418000654 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 517418000655 active site 517418000656 Dehydroquinase class II; Region: DHquinase_II; pfam01220 517418000657 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 517418000658 trimer interface [polypeptide binding]; other site 517418000659 active site 517418000660 dimer interface [polypeptide binding]; other site 517418000661 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 517418000662 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 517418000663 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 517418000664 active site 517418000665 metal binding site [ion binding]; metal-binding site 517418000666 DNA binding site [nucleotide binding] 517418000667 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 517418000668 Predicted amidohydrolase [General function prediction only]; Region: COG0388 517418000669 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 517418000670 putative active site [active] 517418000671 catalytic triad [active] 517418000672 putative dimer interface [polypeptide binding]; other site 517418000673 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 517418000674 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 517418000675 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 517418000676 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 517418000677 putative active site [active] 517418000678 putative metal binding site [ion binding]; other site 517418000679 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 517418000680 probable metal-binding protein; Region: matur_matur; TIGR03853 517418000681 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 517418000682 diaminopimelate decarboxylase; Region: lysA; TIGR01048 517418000683 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 517418000684 active site 517418000685 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 517418000686 substrate binding site [chemical binding]; other site 517418000687 catalytic residues [active] 517418000688 dimer interface [polypeptide binding]; other site 517418000689 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 517418000690 chlorophyllide reductase subunit Y; Region: BchY; TIGR02015 517418000691 Sporulation related domain; Region: SPOR; pfam05036 517418000692 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 517418000693 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 517418000694 TPR repeat; Region: TPR_11; pfam13414 517418000695 TPR repeat; Region: TPR_11; pfam13414 517418000696 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418000697 binding surface 517418000698 TPR motif; other site 517418000699 TPR repeat; Region: TPR_11; pfam13414 517418000700 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418000701 binding surface 517418000702 Tetratricopeptide repeat; Region: TPR_16; pfam13432 517418000703 TPR motif; other site 517418000704 TPR repeat; Region: TPR_11; pfam13414 517418000705 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418000706 binding surface 517418000707 TPR motif; other site 517418000708 TPR repeat; Region: TPR_11; pfam13414 517418000709 Tetratricopeptide repeat; Region: TPR_16; pfam13432 517418000710 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 517418000711 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 517418000712 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 517418000713 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 517418000714 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 517418000715 oligomerization interface [polypeptide binding]; other site 517418000716 active site 517418000717 metal binding site [ion binding]; metal-binding site 517418000718 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 517418000719 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 517418000720 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 517418000721 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 517418000722 ligand binding site [chemical binding]; other site 517418000723 FecR protein; Region: FecR; pfam04773 517418000724 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 517418000725 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 517418000726 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 517418000727 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 517418000728 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 517418000729 putative active site [active] 517418000730 catalytic triad [active] 517418000731 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 517418000732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 517418000733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 517418000734 putative substrate translocation pore; other site 517418000735 L-aspartate oxidase; Provisional; Region: PRK09077 517418000736 L-aspartate oxidase; Provisional; Region: PRK06175 517418000737 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 517418000738 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 517418000739 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 517418000740 G1 box; other site 517418000741 putative GEF interaction site [polypeptide binding]; other site 517418000742 GTP/Mg2+ binding site [chemical binding]; other site 517418000743 Switch I region; other site 517418000744 G2 box; other site 517418000745 G3 box; other site 517418000746 Switch II region; other site 517418000747 G4 box; other site 517418000748 G5 box; other site 517418000749 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 517418000750 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 517418000751 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 517418000752 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 517418000753 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 517418000754 Integral membrane protein DUF92; Region: DUF92; pfam01940 517418000755 Predicted dehydrogenase [General function prediction only]; Region: COG0579 517418000756 hydroxyglutarate oxidase; Provisional; Region: PRK11728 517418000757 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 517418000758 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 517418000759 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 517418000760 catalytic residue [active] 517418000761 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 517418000762 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 517418000763 NAD(P) binding site [chemical binding]; other site 517418000764 active site 517418000765 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 517418000766 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 517418000767 ligand binding site [chemical binding]; other site 517418000768 NAD binding site [chemical binding]; other site 517418000769 dimerization interface [polypeptide binding]; other site 517418000770 catalytic site [active] 517418000771 ACT_3PGDH-like CD includes the C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-like; cd04879 517418000772 L-serine binding site [chemical binding]; other site 517418000773 Protein of unknown function (DUF971); Region: DUF971; pfam06155 517418000774 GAF domain; Region: GAF_2; pfam13185 517418000775 GAF domain; Region: GAF_3; pfam13492 517418000776 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 517418000777 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 517418000778 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 517418000779 anti sigma factor interaction site; other site 517418000780 regulatory phosphorylation site [posttranslational modification]; other site 517418000781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 517418000782 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 517418000783 GAF domain; Region: GAF_3; pfam13492 517418000784 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 517418000785 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 517418000786 flavodoxin; Provisional; Region: PRK06242 517418000787 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 517418000788 acetyl-CoA synthetase; Provisional; Region: PRK00174 517418000789 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 517418000790 active site 517418000791 CoA binding site [chemical binding]; other site 517418000792 acyl-activating enzyme (AAE) consensus motif; other site 517418000793 AMP binding site [chemical binding]; other site 517418000794 acetate binding site [chemical binding]; other site 517418000795 Family description; Region: VCBS; pfam13517 517418000796 Family description; Region: VCBS; pfam13517 517418000797 Family description; Region: VCBS; pfam13517 517418000798 Family description; Region: VCBS; pfam13517 517418000799 Family description; Region: VCBS; pfam13517 517418000800 Family description; Region: VCBS; pfam13517 517418000801 Family description; Region: VCBS; pfam13517 517418000802 Family description; Region: VCBS; pfam13517 517418000803 Family description; Region: VCBS; pfam13517 517418000804 Family description; Region: VCBS; pfam13517 517418000805 Family description; Region: VCBS; pfam13517 517418000806 Family description; Region: VCBS; pfam13517 517418000807 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 517418000808 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 517418000809 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 517418000810 histidinol dehydrogenase; Region: hisD; TIGR00069 517418000811 NAD binding site [chemical binding]; other site 517418000812 dimerization interface [polypeptide binding]; other site 517418000813 product binding site; other site 517418000814 substrate binding site [chemical binding]; other site 517418000815 zinc binding site [ion binding]; other site 517418000816 catalytic residues [active] 517418000817 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 517418000818 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 517418000819 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 517418000820 DsbD alpha interface [polypeptide binding]; other site 517418000821 catalytic residues [active] 517418000822 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 517418000823 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 517418000824 putative catalytic residue [active] 517418000825 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 517418000826 active site 517418000827 catalytic residues [active] 517418000828 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 517418000829 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 517418000830 dimer interface [polypeptide binding]; other site 517418000831 putative tRNA-binding site [nucleotide binding]; other site 517418000832 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 517418000833 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 517418000834 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 517418000835 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 517418000836 HflX GTPase family; Region: HflX; cd01878 517418000837 G1 box; other site 517418000838 GTP/Mg2+ binding site [chemical binding]; other site 517418000839 Switch I region; other site 517418000840 G2 box; other site 517418000841 G3 box; other site 517418000842 Switch II region; other site 517418000843 G4 box; other site 517418000844 G5 box; other site 517418000845 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 517418000846 active site lid residues [active] 517418000847 substrate binding pocket [chemical binding]; other site 517418000848 catalytic residues [active] 517418000849 substrate-Mg2+ binding site; other site 517418000850 aspartate-rich region 1; other site 517418000851 aspartate-rich region 2; other site 517418000852 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 517418000853 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 517418000854 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 517418000855 dimer interface [polypeptide binding]; other site 517418000856 putative anticodon binding site; other site 517418000857 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 517418000858 motif 1; other site 517418000859 active site 517418000860 motif 2; other site 517418000861 motif 3; other site 517418000862 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 517418000863 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 517418000864 Ligand Binding Site [chemical binding]; other site 517418000865 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 517418000866 Ligand Binding Site [chemical binding]; other site 517418000867 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 517418000868 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 517418000869 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 517418000870 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 517418000871 dimer interface [polypeptide binding]; other site 517418000872 substrate binding site [chemical binding]; other site 517418000873 metal binding sites [ion binding]; metal-binding site 517418000874 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 517418000875 active site 517418000876 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 517418000877 anti sigma factor interaction site; other site 517418000878 regulatory phosphorylation site [posttranslational modification]; other site 517418000879 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 517418000880 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 517418000881 Protein export membrane protein; Region: SecD_SecF; pfam02355 517418000882 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 517418000883 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 517418000884 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 517418000885 purine nucleoside phosphorylase; Provisional; Region: PRK08202 517418000886 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 517418000887 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 517418000888 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 517418000889 dimerization interface [polypeptide binding]; other site 517418000890 active site 517418000891 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 517418000892 dihydroneopterin aldolase; Region: folB; TIGR00525 517418000893 active site 517418000894 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 517418000895 catalytic center binding site [active] 517418000896 ATP binding site [chemical binding]; other site 517418000897 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 517418000898 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 517418000899 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 517418000900 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 517418000901 Phage P2 GpU; Region: Phage_P2_GpU; cl01391 517418000902 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 517418000903 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 517418000904 Baseplate J-like protein; Region: Baseplate_J; cl01294 517418000905 Phage tail tube protein FII; Region: Phage_tube; cl01390 517418000906 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 517418000907 Gp37 protein; Region: Gp37; pfam09646 517418000908 Protein of unknown function (DUF3154); Region: DUF3154; pfam11351 517418000909 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 517418000910 Mor transcription activator family; Region: Mor; cl02360 517418000911 Protein of unknown function (DUF1018); Region: DUF1018; cl01815 517418000912 AAA domain; Region: AAA_22; pfam13401 517418000913 AAA ATPase domain; Region: AAA_16; pfam13191 517418000914 Mu DNA binding, I gamma subdomain; Region: HTH_Tnp_Mu_2; pfam09039 517418000915 Integrase core domain; Region: rve; pfam00665 517418000916 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 517418000917 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 517418000918 non-specific DNA binding site [nucleotide binding]; other site 517418000919 salt bridge; other site 517418000920 sequence-specific DNA binding site [nucleotide binding]; other site 517418000921 LexA repressor; Provisional; Region: PRK12423 517418000922 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 517418000923 Catalytic site [active] 517418000924 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 517418000925 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 517418000926 P loop; other site 517418000927 Nucleotide binding site [chemical binding]; other site 517418000928 DTAP/Switch II; other site 517418000929 Switch I; other site 517418000930 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 517418000931 Bacteriochlorophyll C binding protein; Region: Bac_chlorC; pfam02043 517418000932 Chlorosome envelope protein C; Region: Chlorosome_CsmC; pfam11098 517418000933 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 517418000934 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 517418000935 P loop; other site 517418000936 Nucleotide binding site [chemical binding]; other site 517418000937 DTAP/Switch II; other site 517418000938 Switch I; other site 517418000939 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 517418000940 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 517418000941 N-acetyl-D-glucosamine binding site [chemical binding]; other site 517418000942 catalytic residue [active] 517418000943 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 517418000944 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 517418000945 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 517418000946 binding surface 517418000947 TPR motif; other site 517418000948 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 517418000949 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 517418000950 FAD binding pocket [chemical binding]; other site 517418000951 FAD binding motif [chemical binding]; other site 517418000952 phosphate binding motif [ion binding]; other site 517418000953 beta-alpha-beta structure motif; other site 517418000954 NAD binding pocket [chemical binding]; other site 517418000955 Iron coordination center [ion binding]; other site 517418000956 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 517418000957 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 517418000958 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 517418000959 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 517418000960 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 517418000961 Clp amino terminal domain; Region: Clp_N; pfam02861 517418000962 Clp amino terminal domain; Region: Clp_N; pfam02861 517418000963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 517418000964 Walker A motif; other site 517418000965 ATP binding site [chemical binding]; other site 517418000966 Walker B motif; other site 517418000967 arginine finger; other site 517418000968 UvrB/uvrC motif; Region: UVR; pfam02151 517418000969 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 517418000970 Walker A motif; other site 517418000971 ATP binding site [chemical binding]; other site 517418000972 Walker B motif; other site 517418000973 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 517418000974 PSP1 C-terminal conserved region; Region: PSP1; cl00770 517418000975 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 517418000976 putative hydrophobic ligand binding site [chemical binding]; other site 517418000977 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 517418000978 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 517418000979 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 517418000980 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 517418000981 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 517418000982 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 517418000983 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 517418000984 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 517418000985 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 517418000986 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 517418000987 DEAD-like helicases superfamily; Region: DEXDc; smart00487 517418000988 ATP binding site [chemical binding]; other site 517418000989 Mg++ binding site [ion binding]; other site 517418000990 motif III; other site 517418000991 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 517418000992 nucleotide binding region [chemical binding]; other site 517418000993 ATP-binding site [chemical binding]; other site 517418000994 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 517418000995 SurA N-terminal domain; Region: SurA_N_3; cl07813 517418000996 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 517418000997 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 517418000998 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 517418000999 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 517418001000 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 517418001001 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 517418001002 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 517418001003 Walker A/P-loop; other site 517418001004 ATP binding site [chemical binding]; other site 517418001005 Q-loop/lid; other site 517418001006 ABC transporter signature motif; other site 517418001007 Walker B; other site 517418001008 D-loop; other site 517418001009 H-loop/switch region; other site 517418001010 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 517418001011 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 517418001012 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 517418001013 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 517418001014 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 517418001015 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 517418001016 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 517418001017 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 517418001018 Walker A/P-loop; other site 517418001019 ATP binding site [chemical binding]; other site 517418001020 Q-loop/lid; other site 517418001021 ABC transporter signature motif; other site 517418001022 Walker B; other site 517418001023 D-loop; other site 517418001024 H-loop/switch region; other site 517418001025 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 517418001026 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 517418001027 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 517418001028 NAD(P) binding site [chemical binding]; other site 517418001029 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 517418001030 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 517418001031 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 517418001032 substrate binding pocket [chemical binding]; other site 517418001033 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 517418001034 B12 binding site [chemical binding]; other site 517418001035 cobalt ligand [ion binding]; other site 517418001036 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 517418001037 Transcription elongation factor Elf1 like; Region: Elf1; cl02038 517418001038 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 517418001039 DctM-like transporters; Region: DctM; pfam06808 517418001040 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 517418001041 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 517418001042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 517418001043 S-adenosylmethionine binding site [chemical binding]; other site 517418001044 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 517418001045 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 517418001046 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 517418001047 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 517418001048 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 517418001049 Walker A motif; other site 517418001050 ATP binding site [chemical binding]; other site 517418001051 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 517418001052 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 517418001053 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 517418001054 homodimer interface [polypeptide binding]; other site 517418001055 substrate-cofactor binding pocket; other site 517418001056 catalytic residue [active] 517418001057 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 517418001058 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 517418001059 putative acyl-acceptor binding pocket; other site 517418001060 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 517418001061 active site residue [active] 517418001062 Low molecular weight phosphatase family; Region: LMWPc; cl00105 517418001063 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 517418001064 active site 517418001065 Predicted membrane protein [Function unknown]; Region: COG1238 517418001066 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 517418001067 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 517418001068 S-adenosylmethionine binding site [chemical binding]; other site 517418001069 EDD domain protein, DegV family; Region: DegV; TIGR00762 517418001070 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 517418001071 Protein of unknown function (DUF525); Region: DUF525; cl01119 517418001072 Protein of unknown function (DUF3808); Region: DUF3808; pfam10300 517418001073 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418001074 binding surface 517418001075 TPR motif; other site 517418001076 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 517418001077 TPR motif; other site 517418001078 binding surface 517418001079 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 517418001080 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 517418001081 putative active site [active] 517418001082 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 517418001083 Synechococcus sp. strain PCC 7942 PhoA and related proteins, N-terminal metallophosphatase domain; Region: MPP_PhoA_N; cd08162 517418001084 putative active site [active] 517418001085 putative metal binding site [ion binding]; other site 517418001086 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 517418001087 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 517418001088 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 517418001089 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 517418001090 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 517418001091 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 517418001092 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 517418001093 FAD binding pocket [chemical binding]; other site 517418001094 FAD binding motif [chemical binding]; other site 517418001095 phosphate binding motif [ion binding]; other site 517418001096 beta-alpha-beta structure motif; other site 517418001097 NAD binding pocket [chemical binding]; other site 517418001098 Iron coordination center [ion binding]; other site 517418001099 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 517418001100 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 517418001101 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 517418001102 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 517418001103 protein binding site [polypeptide binding]; other site 517418001104 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 517418001105 protein binding site [polypeptide binding]; other site 517418001106 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 517418001107 Recombination protein O N terminal; Region: RecO_N; pfam11967 517418001108 Recombination protein O C terminal; Region: RecO_C; pfam02565 517418001109 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 517418001110 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 517418001111 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 517418001112 NAD(P) binding site [chemical binding]; other site 517418001113 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 517418001114 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 517418001115 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 517418001116 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 517418001117 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 517418001118 Probable Catalytic site; other site 517418001119 Surface antigen; Region: Bac_surface_Ag; pfam01103 517418001120 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 517418001121 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 517418001122 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 517418001123 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 517418001124 Ligand binding site; other site 517418001125 Putative Catalytic site; other site 517418001126 DXD motif; other site 517418001127 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 517418001128 adenosine deaminase; Provisional; Region: PRK09358 517418001129 active site 517418001130 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418001131 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418001132 TPR motif; other site 517418001133 binding surface 517418001134 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418001135 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418001136 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418001137 binding surface 517418001138 TPR motif; other site 517418001139 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 517418001140 metal binding site [ion binding]; metal-binding site 517418001141 active site 517418001142 I-site; other site 517418001143 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 517418001144 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 517418001145 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 517418001146 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 517418001147 active site 517418001148 dimer interface [polypeptide binding]; other site 517418001149 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 517418001150 Ligand Binding Site [chemical binding]; other site 517418001151 Molecular Tunnel; other site 517418001152 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 517418001153 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 517418001154 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG1817 517418001155 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 517418001156 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 517418001157 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 517418001158 Bacterial sugar transferase; Region: Bac_transf; pfam02397 517418001159 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 517418001160 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 517418001161 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 517418001162 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 517418001163 putative trimer interface [polypeptide binding]; other site 517418001164 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 517418001165 putative trimer interface [polypeptide binding]; other site 517418001166 putative CoA binding site [chemical binding]; other site 517418001167 Phosphopantetheine attachment site; Region: PP-binding; cl09936 517418001168 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 517418001169 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 517418001170 acyl-activating enzyme (AAE) consensus motif; other site 517418001171 AMP binding site [chemical binding]; other site 517418001172 active site 517418001173 CoA binding site [chemical binding]; other site 517418001174 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 517418001175 classical (c) SDRs; Region: SDR_c; cd05233 517418001176 NAD(P) binding site [chemical binding]; other site 517418001177 active site 517418001178 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418001179 binding surface 517418001180 TPR motif; other site 517418001181 TPR repeat; Region: TPR_11; pfam13414 517418001182 TPR repeat; Region: TPR_11; pfam13414 517418001183 TPR repeat; Region: TPR_11; pfam13414 517418001184 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418001185 binding surface 517418001186 TPR motif; other site 517418001187 TPR repeat; Region: TPR_11; pfam13414 517418001188 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418001189 binding surface 517418001190 TPR motif; other site 517418001191 TPR repeat; Region: TPR_11; pfam13414 517418001192 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 517418001193 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 517418001194 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 517418001195 structural tetrad; other site 517418001196 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 517418001197 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 517418001198 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 517418001199 protein binding site [polypeptide binding]; other site 517418001200 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 517418001201 Domain interface; other site 517418001202 Peptide binding site; other site 517418001203 Active site tetrad [active] 517418001204 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 517418001205 HD domain; Region: HD_4; pfam13328 517418001206 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 517418001207 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 517418001208 substrate binding pocket [chemical binding]; other site 517418001209 membrane-bound complex binding site; other site 517418001210 hinge residues; other site 517418001211 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 517418001212 N-acetyl-D-glucosamine binding site [chemical binding]; other site 517418001213 catalytic residue [active] 517418001214 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 517418001215 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 517418001216 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 517418001217 DXD motif; other site 517418001218 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 517418001219 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 517418001220 Probable Catalytic site; other site 517418001221 metal-binding site 517418001222 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 517418001223 CHAT domain; Region: CHAT; pfam12770 517418001224 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418001225 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418001226 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418001227 binding surface 517418001228 TPR motif; other site 517418001229 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418001230 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418001231 binding surface 517418001232 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418001233 TPR motif; other site 517418001234 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418001235 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 517418001236 trimer interface [polypeptide binding]; other site 517418001237 active site 517418001238 substrate binding site [chemical binding]; other site 517418001239 CoA binding site [chemical binding]; other site 517418001240 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 517418001241 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 517418001242 putative homodimer interface [polypeptide binding]; other site 517418001243 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 517418001244 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 517418001245 active site 517418001246 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 517418001247 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 517418001248 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 517418001249 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 517418001250 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 517418001251 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 517418001252 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 517418001253 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 517418001254 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 517418001255 DXD motif; other site 517418001256 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 517418001257 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 517418001258 Outer membrane efflux protein; Region: OEP; pfam02321 517418001259 Response regulator receiver domain; Region: Response_reg; pfam00072 517418001260 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 517418001261 active site 517418001262 phosphorylation site [posttranslational modification] 517418001263 intermolecular recognition site; other site 517418001264 dimerization interface [polypeptide binding]; other site 517418001265 Bacterial sugar transferase; Region: Bac_transf; pfam02397 517418001266 Response regulator receiver domain; Region: Response_reg; pfam00072 517418001267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418001268 active site 517418001269 phosphorylation site [posttranslational modification] 517418001270 intermolecular recognition site; other site 517418001271 dimerization interface [polypeptide binding]; other site 517418001272 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cd00352 517418001273 active site 517418001274 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 517418001275 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 517418001276 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 517418001277 putative active site [active] 517418001278 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 517418001279 heme-binding site [chemical binding]; other site 517418001280 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 517418001281 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 517418001282 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 517418001283 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 517418001284 G1 box; other site 517418001285 GTP/Mg2+ binding site [chemical binding]; other site 517418001286 G2 box; other site 517418001287 Switch I region; other site 517418001288 G3 box; other site 517418001289 Switch II region; other site 517418001290 G4 box; other site 517418001291 G5 box; other site 517418001292 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 517418001293 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 517418001294 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 517418001295 FtsX-like permease family; Region: FtsX; pfam02687 517418001296 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 517418001297 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 517418001298 homotetramer interface [polypeptide binding]; other site 517418001299 FMN binding site [chemical binding]; other site 517418001300 homodimer contacts [polypeptide binding]; other site 517418001301 putative active site [active] 517418001302 putative substrate binding site [chemical binding]; other site 517418001303 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 517418001304 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 517418001305 substrate binding pocket [chemical binding]; other site 517418001306 chain length determination region; other site 517418001307 substrate-Mg2+ binding site; other site 517418001308 catalytic residues [active] 517418001309 aspartate-rich region 1; other site 517418001310 active site lid residues [active] 517418001311 aspartate-rich region 2; other site 517418001312 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 517418001313 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 517418001314 Nitrogen regulatory protein P-II; Region: P-II; smart00938 517418001315 ammonium transporter; Region: amt; TIGR00836 517418001316 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 517418001317 HEAT repeats; Region: HEAT_2; pfam13646 517418001318 HEAT repeats; Region: HEAT_2; pfam13646 517418001319 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 517418001320 active site 517418001321 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 517418001322 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 517418001323 dimer interface [polypeptide binding]; other site 517418001324 phosphorylation site [posttranslational modification] 517418001325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418001326 ATP binding site [chemical binding]; other site 517418001327 Mg2+ binding site [ion binding]; other site 517418001328 G-X-G motif; other site 517418001329 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 517418001330 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 517418001331 metal ion-dependent adhesion site (MIDAS); other site 517418001332 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 517418001333 HlyD family secretion protein; Region: HlyD_2; pfam12700 517418001334 HlyD family secretion protein; Region: HlyD_3; pfam13437 517418001335 Outer membrane efflux protein; Region: OEP; pfam02321 517418001336 Outer membrane efflux protein; Region: OEP; pfam02321 517418001337 HerA helicase [Replication, recombination, and repair]; Region: COG0433 517418001338 Domain of unknown function DUF87; Region: DUF87; pfam01935 517418001339 Membrane protein of unknown function; Region: DUF360; pfam04020 517418001340 Uncharacterized conserved protein [Function unknown]; Region: COG5316 517418001341 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 517418001342 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 517418001343 glutamate racemase; Provisional; Region: PRK00865 517418001344 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 517418001345 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 517418001346 Walker A motif; other site 517418001347 ATP binding site [chemical binding]; other site 517418001348 Walker B motif; other site 517418001349 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 517418001350 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 517418001351 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 517418001352 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 517418001353 tetramer interface [polypeptide binding]; other site 517418001354 TPP-binding site [chemical binding]; other site 517418001355 heterodimer interface [polypeptide binding]; other site 517418001356 phosphorylation loop region [posttranslational modification] 517418001357 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 517418001358 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 517418001359 alpha subunit interface [polypeptide binding]; other site 517418001360 TPP binding site [chemical binding]; other site 517418001361 heterodimer interface [polypeptide binding]; other site 517418001362 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 517418001363 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 517418001364 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 517418001365 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 517418001366 putative active site [active] 517418001367 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 517418001368 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 517418001369 DNA topoisomerase I; Validated; Region: PRK06599 517418001370 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 517418001371 active site 517418001372 interdomain interaction site; other site 517418001373 putative metal-binding site [ion binding]; other site 517418001374 nucleotide binding site [chemical binding]; other site 517418001375 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 517418001376 domain I; other site 517418001377 DNA binding groove [nucleotide binding] 517418001378 phosphate binding site [ion binding]; other site 517418001379 domain II; other site 517418001380 domain III; other site 517418001381 nucleotide binding site [chemical binding]; other site 517418001382 catalytic site [active] 517418001383 domain IV; other site 517418001384 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 517418001385 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 517418001386 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 517418001387 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 517418001388 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 517418001389 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 517418001390 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 517418001391 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 517418001392 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 517418001393 Walker A/P-loop; other site 517418001394 ATP binding site [chemical binding]; other site 517418001395 Q-loop/lid; other site 517418001396 ABC transporter signature motif; other site 517418001397 Walker B; other site 517418001398 D-loop; other site 517418001399 H-loop/switch region; other site 517418001400 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 517418001401 Walker A/P-loop; other site 517418001402 ATP binding site [chemical binding]; other site 517418001403 Q-loop/lid; other site 517418001404 ABC transporter signature motif; other site 517418001405 Walker B; other site 517418001406 D-loop; other site 517418001407 H-loop/switch region; other site 517418001408 AAA domain; Region: AAA_22; pfam13401 517418001409 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 517418001410 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 517418001411 Walker A motif; other site 517418001412 ATP binding site [chemical binding]; other site 517418001413 Walker B motif; other site 517418001414 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418001415 TPR motif; other site 517418001416 binding surface 517418001417 TPR repeat; Region: TPR_11; pfam13414 517418001418 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418001419 binding surface 517418001420 TPR motif; other site 517418001421 TPR repeat; Region: TPR_11; pfam13414 517418001422 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418001423 binding surface 517418001424 TPR motif; other site 517418001425 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 517418001426 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418001427 binding surface 517418001428 TPR motif; other site 517418001429 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418001430 binding surface 517418001431 TPR motif; other site 517418001432 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 517418001433 S-adenosylmethionine binding site [chemical binding]; other site 517418001434 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 517418001435 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 517418001436 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 517418001437 N-terminal plug; other site 517418001438 ligand-binding site [chemical binding]; other site 517418001439 Peptidase family M48; Region: Peptidase_M48; pfam01435 517418001440 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 517418001441 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 517418001442 dimerization interface 3.5A [polypeptide binding]; other site 517418001443 active site 517418001444 Alpha amylase catalytic domain found in maltosyltransferase; Region: AmyAc_MTase_N; cd11335 517418001445 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 517418001446 homodimer interface [polypeptide binding]; other site 517418001447 active site 517418001448 catalytic site [active] 517418001449 maltose binding site 2 [chemical binding]; other site 517418001450 Ribokinase-like subgroup C. Found only in bacteria, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_C; cd01946 517418001451 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 517418001452 substrate binding site [chemical binding]; other site 517418001453 ATP binding site [chemical binding]; other site 517418001454 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 517418001455 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 517418001456 NAD binding site [chemical binding]; other site 517418001457 putative substrate binding site 2 [chemical binding]; other site 517418001458 putative substrate binding site 1 [chemical binding]; other site 517418001459 active site 517418001460 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14174 517418001461 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 517418001462 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 517418001463 homodimer interface [polypeptide binding]; other site 517418001464 NADP binding site [chemical binding]; other site 517418001465 substrate binding site [chemical binding]; other site 517418001466 4Fe-4S binding domain; Region: Fer4; cl02805 517418001467 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 517418001468 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 517418001469 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 517418001470 DNA binding residues [nucleotide binding] 517418001471 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 517418001472 DNA polymerase III, delta subunit; Region: holA; TIGR01128 517418001473 CHAD domain; Region: CHAD; cl10506 517418001474 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 517418001475 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 517418001476 Coenzyme A binding pocket [chemical binding]; other site 517418001477 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 517418001478 L-aspartate oxidase; Provisional; Region: PRK06175 517418001479 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 517418001480 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 517418001481 putative Iron-sulfur protein interface [polypeptide binding]; other site 517418001482 putative proximal heme binding site [chemical binding]; other site 517418001483 putative SdhC-like subunit interface [polypeptide binding]; other site 517418001484 putative distal heme binding site [chemical binding]; other site 517418001485 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 517418001486 putative Iron-sulfur protein interface [polypeptide binding]; other site 517418001487 putative proximal heme binding site [chemical binding]; other site 517418001488 putative SdhD-like interface [polypeptide binding]; other site 517418001489 putative distal heme binding site [chemical binding]; other site 517418001490 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418001491 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418001492 binding surface 517418001493 TPR motif; other site 517418001494 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418001495 Tetratricopeptide repeat; Region: TPR_10; pfam13374 517418001496 acetyl-CoA synthetase; Provisional; Region: PRK00174 517418001497 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 517418001498 acyl-activating enzyme (AAE) consensus motif; other site 517418001499 active site 517418001500 AMP binding site [chemical binding]; other site 517418001501 CoA binding site [chemical binding]; other site 517418001502 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 517418001503 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 517418001504 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 517418001505 Substrate-binding site [chemical binding]; other site 517418001506 Substrate specificity [chemical binding]; other site 517418001507 ribosome maturation protein RimP; Reviewed; Region: PRK00092 517418001508 Sm and related proteins; Region: Sm_like; cl00259 517418001509 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 517418001510 putative oligomer interface [polypeptide binding]; other site 517418001511 putative RNA binding site [nucleotide binding]; other site 517418001512 NusA N-terminal domain; Region: NusA_N; pfam08529 517418001513 transcription termination factor NusA; Region: NusA; TIGR01953 517418001514 NusA-like KH domain; Region: KH_5; pfam13184 517418001515 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 517418001516 G-X-X-G motif; other site 517418001517 translation initiation factor IF-2; Region: IF-2; TIGR00487 517418001518 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 517418001519 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 517418001520 G1 box; other site 517418001521 putative GEF interaction site [polypeptide binding]; other site 517418001522 GTP/Mg2+ binding site [chemical binding]; other site 517418001523 Switch I region; other site 517418001524 G2 box; other site 517418001525 G3 box; other site 517418001526 Switch II region; other site 517418001527 G4 box; other site 517418001528 G5 box; other site 517418001529 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 517418001530 Translation-initiation factor 2; Region: IF-2; pfam11987 517418001531 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 517418001532 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 517418001533 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 517418001534 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 517418001535 metal ion-dependent adhesion site (MIDAS); other site 517418001536 OPT oligopeptide transporter protein; Region: OPT; pfam03169 517418001537 oligopeptide transporter, OPT superfamily; Region: OPT_sfam; TIGR00728 517418001538 Response regulator receiver domain; Region: Response_reg; pfam00072 517418001539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418001540 active site 517418001541 phosphorylation site [posttranslational modification] 517418001542 intermolecular recognition site; other site 517418001543 dimerization interface [polypeptide binding]; other site 517418001544 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 517418001545 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 517418001546 Ferredoxin [Energy production and conversion]; Region: COG1146 517418001547 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 517418001548 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 517418001549 intrachain domain interface; other site 517418001550 interchain domain interface [polypeptide binding]; other site 517418001551 heme bH binding site [chemical binding]; other site 517418001552 Qi binding site; other site 517418001553 heme bL binding site [chemical binding]; other site 517418001554 Qo binding site; other site 517418001555 interchain domain interface [polypeptide binding]; other site 517418001556 intrachain domain interface; other site 517418001557 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 517418001558 Qi binding site; other site 517418001559 Qo binding site; other site 517418001560 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 517418001561 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 517418001562 iron-sulfur cluster [ion binding]; other site 517418001563 [2Fe-2S] cluster binding site [ion binding]; other site 517418001564 DinB superfamily; Region: DinB_2; pfam12867 517418001565 exopolyphosphatase; Region: exo_poly_only; TIGR03706 517418001566 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 517418001567 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 517418001568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418001569 active site 517418001570 phosphorylation site [posttranslational modification] 517418001571 intermolecular recognition site; other site 517418001572 dimerization interface [polypeptide binding]; other site 517418001573 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 517418001574 DNA binding site [nucleotide binding] 517418001575 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 517418001576 dimer interface [polypeptide binding]; other site 517418001577 catalytic triad [active] 517418001578 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 517418001579 gamma subunit interface [polypeptide binding]; other site 517418001580 LBP interface [polypeptide binding]; other site 517418001581 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 517418001582 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 517418001583 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 517418001584 alpha subunit interaction interface [polypeptide binding]; other site 517418001585 Walker A motif; other site 517418001586 ATP binding site [chemical binding]; other site 517418001587 Walker B motif; other site 517418001588 inhibitor binding site; inhibition site 517418001589 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 517418001590 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 517418001591 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 517418001592 FeS/SAM binding site; other site 517418001593 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 517418001594 putative ligand binding pocket/active site [active] 517418001595 putative metal binding site [ion binding]; other site 517418001596 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 517418001597 structural tetrad; other site 517418001598 FOG: WD40 repeat [General function prediction only]; Region: COG2319 517418001599 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 517418001600 active site 517418001601 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 517418001602 GTP cyclohydrolase I; Provisional; Region: PLN03044 517418001603 active site 517418001604 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 517418001605 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 517418001606 putative active site [active] 517418001607 putative metal binding site [ion binding]; other site 517418001608 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 517418001609 Domain of unknown function DUF20; Region: UPF0118; pfam01594 517418001610 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 517418001611 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418001612 heme pocket [chemical binding]; other site 517418001613 putative active site [active] 517418001614 histidine kinase; Provisional; Region: PRK13557 517418001615 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418001616 putative active site [active] 517418001617 heme pocket [chemical binding]; other site 517418001618 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 517418001619 dimer interface [polypeptide binding]; other site 517418001620 phosphorylation site [posttranslational modification] 517418001621 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418001622 ATP binding site [chemical binding]; other site 517418001623 Mg2+ binding site [ion binding]; other site 517418001624 G-X-G motif; other site 517418001625 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418001626 active site 517418001627 phosphorylation site [posttranslational modification] 517418001628 intermolecular recognition site; other site 517418001629 dimerization interface [polypeptide binding]; other site 517418001630 PAS fold; Region: PAS_4; pfam08448 517418001631 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418001632 PAS fold; Region: PAS_3; pfam08447 517418001633 putative active site [active] 517418001634 heme pocket [chemical binding]; other site 517418001635 PAS domain S-box; Region: sensory_box; TIGR00229 517418001636 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418001637 putative active site [active] 517418001638 heme pocket [chemical binding]; other site 517418001639 PAS domain S-box; Region: sensory_box; TIGR00229 517418001640 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418001641 putative active site [active] 517418001642 heme pocket [chemical binding]; other site 517418001643 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 517418001644 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 517418001645 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_e; cd04192 517418001646 SurA N-terminal domain; Region: SurA_N_3; cl07813 517418001647 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 517418001648 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 517418001649 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 517418001650 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 517418001651 active site 517418001652 dimerization interface [polypeptide binding]; other site 517418001653 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 517418001654 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 517418001655 ligand binding site [chemical binding]; other site 517418001656 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 517418001657 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 517418001658 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 517418001659 active site 517418001660 catalytic site [active] 517418001661 substrate binding site [chemical binding]; other site 517418001662 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 517418001663 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 517418001664 CHASE2 domain; Region: CHASE2; pfam05226 517418001665 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 517418001666 cyclase homology domain; Region: CHD; cd07302 517418001667 nucleotidyl binding site; other site 517418001668 metal binding site [ion binding]; metal-binding site 517418001669 dimer interface [polypeptide binding]; other site 517418001670 methionine sulfoxide reductase B; Provisional; Region: PRK00222 517418001671 SelR domain; Region: SelR; pfam01641 517418001672 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 517418001673 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 517418001674 FtsX-like permease family; Region: FtsX; pfam02687 517418001675 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 517418001676 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 517418001677 Walker A/P-loop; other site 517418001678 ATP binding site [chemical binding]; other site 517418001679 Q-loop/lid; other site 517418001680 ABC transporter signature motif; other site 517418001681 Walker B; other site 517418001682 D-loop; other site 517418001683 H-loop/switch region; other site 517418001684 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 517418001685 HlyD family secretion protein; Region: HlyD_3; pfam13437 517418001686 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 517418001687 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 517418001688 Zn2+ binding site [ion binding]; other site 517418001689 Mg2+ binding site [ion binding]; other site 517418001690 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 517418001691 synthetase active site [active] 517418001692 NTP binding site [chemical binding]; other site 517418001693 metal binding site [ion binding]; metal-binding site 517418001694 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 517418001695 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 517418001696 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 517418001697 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 517418001698 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 517418001699 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 517418001700 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 517418001701 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 517418001702 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 517418001703 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 517418001704 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 517418001705 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 517418001706 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 517418001707 propionate/acetate kinase; Provisional; Region: PRK12379 517418001708 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 517418001709 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 517418001710 active site 517418001711 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 517418001712 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 517418001713 active site 517418001714 catalytic site [active] 517418001715 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 517418001716 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 517418001717 Lipopolysaccharide-assembly; Region: LptE; pfam04390 517418001718 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 517418001719 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 517418001720 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 517418001721 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 517418001722 active site 517418001723 HIGH motif; other site 517418001724 dimer interface [polypeptide binding]; other site 517418001725 KMSKS motif; other site 517418001726 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 517418001727 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 517418001728 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 517418001729 motif II; other site 517418001730 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 517418001731 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 517418001732 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 517418001733 active site 517418001734 HIGH motif; other site 517418001735 KMSK motif region; other site 517418001736 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 517418001737 tRNA binding surface [nucleotide binding]; other site 517418001738 anticodon binding site; other site 517418001739 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 517418001740 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 517418001741 Zn2+ binding site [ion binding]; other site 517418001742 Mg2+ binding site [ion binding]; other site 517418001743 YtxH-like protein; Region: YtxH; pfam12732 517418001744 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 517418001745 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 517418001746 classical (c) SDRs; Region: SDR_c; cd05233 517418001747 NAD(P) binding site [chemical binding]; other site 517418001748 active site 517418001749 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 517418001750 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 517418001751 active site 517418001752 Substrate binding site; other site 517418001753 Mg++ binding site; other site 517418001754 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 517418001755 putative trimer interface [polypeptide binding]; other site 517418001756 putative CoA binding site [chemical binding]; other site 517418001757 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 517418001758 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 517418001759 active site 517418001760 substrate binding site [chemical binding]; other site 517418001761 metal binding site [ion binding]; metal-binding site 517418001762 recombination regulator RecX; Reviewed; Region: recX; PRK00117 517418001763 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 517418001764 putative nucleotide binding site [chemical binding]; other site 517418001765 uridine monophosphate binding site [chemical binding]; other site 517418001766 homohexameric interface [polypeptide binding]; other site 517418001767 elongation factor Ts; Provisional; Region: tsf; PRK09377 517418001768 UBA/TS-N domain; Region: UBA; pfam00627 517418001769 Elongation factor TS; Region: EF_TS; pfam00889 517418001770 Elongation factor TS; Region: EF_TS; pfam00889 517418001771 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 517418001772 rRNA interaction site [nucleotide binding]; other site 517418001773 S8 interaction site; other site 517418001774 putative laminin-1 binding site; other site 517418001775 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 517418001776 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 517418001777 23S rRNA interface [nucleotide binding]; other site 517418001778 L3 interface [polypeptide binding]; other site 517418001779 rod shape-determining protein MreB; Provisional; Region: PRK13930 517418001780 MreB and similar proteins; Region: MreB_like; cd10225 517418001781 nucleotide binding site [chemical binding]; other site 517418001782 Mg binding site [ion binding]; other site 517418001783 putative protofilament interaction site [polypeptide binding]; other site 517418001784 RodZ interaction site [polypeptide binding]; other site 517418001785 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 517418001786 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 517418001787 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 517418001788 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 517418001789 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 517418001790 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 517418001791 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 517418001792 triosephosphate isomerase; Provisional; Region: PRK14567 517418001793 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 517418001794 substrate binding site [chemical binding]; other site 517418001795 dimer interface [polypeptide binding]; other site 517418001796 catalytic triad [active] 517418001797 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 517418001798 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 517418001799 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 517418001800 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 517418001801 substrate binding site [chemical binding]; other site 517418001802 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 517418001803 FAD binding site [chemical binding]; other site 517418001804 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347 517418001805 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 517418001806 active site 517418001807 catalytic site [active] 517418001808 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 517418001809 active site 517418001810 dimer interface [polypeptide binding]; other site 517418001811 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 517418001812 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 517418001813 glutaminase active site [active] 517418001814 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 517418001815 dimer interface [polypeptide binding]; other site 517418001816 active site 517418001817 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 517418001818 dimer interface [polypeptide binding]; other site 517418001819 active site 517418001820 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 517418001821 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 517418001822 active site 517418001823 Response regulator receiver domain; Region: Response_reg; pfam00072 517418001824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418001825 active site 517418001826 phosphorylation site [posttranslational modification] 517418001827 intermolecular recognition site; other site 517418001828 dimerization interface [polypeptide binding]; other site 517418001829 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 517418001830 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 517418001831 G1 box; other site 517418001832 GTP/Mg2+ binding site [chemical binding]; other site 517418001833 G2 box; other site 517418001834 Switch I region; other site 517418001835 G3 box; other site 517418001836 Switch II region; other site 517418001837 G4 box; other site 517418001838 G5 box; other site 517418001839 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 517418001840 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 517418001841 metal-binding site [ion binding] 517418001842 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 517418001843 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 517418001844 metal-binding site [ion binding] 517418001845 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 517418001846 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 517418001847 motif II; other site 517418001848 camphor resistance protein CrcB; Provisional; Region: PRK14202 517418001849 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 517418001850 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 517418001851 putative RNA binding site [nucleotide binding]; other site 517418001852 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 517418001853 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 517418001854 active site 517418001855 metal binding site [ion binding]; metal-binding site 517418001856 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 517418001857 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 517418001858 minor groove reading motif; other site 517418001859 helix-hairpin-helix signature motif; other site 517418001860 substrate binding pocket [chemical binding]; other site 517418001861 active site 517418001862 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 517418001863 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 517418001864 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 517418001865 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 517418001866 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 517418001867 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 517418001868 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 517418001869 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 517418001870 homodimer interface [polypeptide binding]; other site 517418001871 metal binding site [ion binding]; metal-binding site 517418001872 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 517418001873 homodimer interface [polypeptide binding]; other site 517418001874 active site 517418001875 putative chemical substrate binding site [chemical binding]; other site 517418001876 metal binding site [ion binding]; metal-binding site 517418001877 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 517418001878 putative active site [active] 517418001879 seryl-tRNA synthetase; Provisional; Region: PRK05431 517418001880 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 517418001881 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 517418001882 dimer interface [polypeptide binding]; other site 517418001883 active site 517418001884 motif 1; other site 517418001885 motif 2; other site 517418001886 motif 3; other site 517418001887 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 517418001888 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 517418001889 Yqey-like protein; Region: YqeY; cl17540 517418001890 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 517418001891 homotrimer interaction site [polypeptide binding]; other site 517418001892 zinc binding site [ion binding]; other site 517418001893 CDP-binding sites; other site 517418001894 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 517418001895 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 517418001896 Walker A/P-loop; other site 517418001897 ATP binding site [chemical binding]; other site 517418001898 Q-loop/lid; other site 517418001899 ABC transporter signature motif; other site 517418001900 Walker B; other site 517418001901 D-loop; other site 517418001902 H-loop/switch region; other site 517418001903 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 517418001904 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 517418001905 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 517418001906 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 517418001907 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 517418001908 inhibitor-cofactor binding pocket; inhibition site 517418001909 pyridoxal 5'-phosphate binding site [chemical binding]; other site 517418001910 catalytic residue [active] 517418001911 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 517418001912 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 517418001913 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 517418001914 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 517418001915 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 517418001916 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 517418001917 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 517418001918 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 517418001919 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 517418001920 active site 517418001921 catalytic site [active] 517418001922 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 517418001923 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 517418001924 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 517418001925 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 517418001926 active site 517418001927 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 517418001928 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 517418001929 P loop; other site 517418001930 Nucleotide binding site [chemical binding]; other site 517418001931 DTAP/Switch II; other site 517418001932 Switch I; other site 517418001933 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 517418001934 MPT binding site; other site 517418001935 trimer interface [polypeptide binding]; other site 517418001936 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 517418001937 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 517418001938 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 517418001939 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 517418001940 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 517418001941 putative active site [active] 517418001942 putative metal binding site [ion binding]; other site 517418001943 bacteriochlorophyll c synthase; Provisional; Region: PRK12392 517418001944 UbiA prenyltransferase family; Region: UbiA; pfam01040 517418001945 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 517418001946 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 517418001947 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 517418001948 FeS/SAM binding site; other site 517418001949 TRAM domain; Region: TRAM; pfam01938 517418001950 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 517418001951 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 517418001952 FtsX-like permease family; Region: FtsX; pfam02687 517418001953 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 517418001954 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 517418001955 FtsX-like permease family; Region: FtsX; pfam02687 517418001956 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 517418001957 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 517418001958 Walker A/P-loop; other site 517418001959 ATP binding site [chemical binding]; other site 517418001960 Q-loop/lid; other site 517418001961 ABC transporter signature motif; other site 517418001962 Walker B; other site 517418001963 D-loop; other site 517418001964 H-loop/switch region; other site 517418001965 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 517418001966 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 517418001967 active site 517418001968 substrate binding site [chemical binding]; other site 517418001969 metal binding site [ion binding]; metal-binding site 517418001970 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 517418001971 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 517418001972 Ligand binding site; other site 517418001973 Putative Catalytic site; other site 517418001974 DXD motif; other site 517418001975 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 517418001976 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 517418001977 dimer interface [polypeptide binding]; other site 517418001978 substrate binding site [chemical binding]; other site 517418001979 metal binding site [ion binding]; metal-binding site 517418001980 transcription termination factor Rho; Provisional; Region: rho; PRK09376 517418001981 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 517418001982 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 517418001983 RNA binding site [nucleotide binding]; other site 517418001984 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 517418001985 multimer interface [polypeptide binding]; other site 517418001986 Walker A motif; other site 517418001987 ATP binding site [chemical binding]; other site 517418001988 Walker B motif; other site 517418001989 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 517418001990 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 517418001991 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 517418001992 RuvA N terminal domain; Region: RuvA_N; pfam01330 517418001993 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 517418001994 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 517418001995 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 517418001996 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 517418001997 motif 1; other site 517418001998 active site 517418001999 motif 2; other site 517418002000 motif 3; other site 517418002001 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 517418002002 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418002003 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418002004 binding surface 517418002005 TPR motif; other site 517418002006 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418002007 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418002008 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418002009 binding surface 517418002010 TPR motif; other site 517418002011 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418002012 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418002013 binding surface 517418002014 TPR motif; other site 517418002015 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418002016 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418002017 Tetratricopeptide repeat; Region: TPR_10; cl17452 517418002018 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 517418002019 Walker A motif; other site 517418002020 ATP binding site [chemical binding]; other site 517418002021 Walker B motif; other site 517418002022 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 517418002023 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 517418002024 active site 517418002025 HIGH motif; other site 517418002026 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 517418002027 KMSKS motif; other site 517418002028 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 517418002029 tRNA binding surface [nucleotide binding]; other site 517418002030 anticodon binding site; other site 517418002031 Protein of unknown function (DUF429); Region: DUF429; pfam04250 517418002032 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 517418002033 Hemerythrin; Region: Hemerythrin; cd12107 517418002034 Fe binding site [ion binding]; other site 517418002035 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 517418002036 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 517418002037 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418002038 putative active site [active] 517418002039 heme pocket [chemical binding]; other site 517418002040 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 517418002041 dimer interface [polypeptide binding]; other site 517418002042 phosphorylation site [posttranslational modification] 517418002043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418002044 ATP binding site [chemical binding]; other site 517418002045 Mg2+ binding site [ion binding]; other site 517418002046 G-X-G motif; other site 517418002047 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418002048 Response regulator receiver domain; Region: Response_reg; pfam00072 517418002049 active site 517418002050 phosphorylation site [posttranslational modification] 517418002051 intermolecular recognition site; other site 517418002052 dimerization interface [polypeptide binding]; other site 517418002053 Response regulator receiver domain; Region: Response_reg; pfam00072 517418002054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418002055 active site 517418002056 phosphorylation site [posttranslational modification] 517418002057 intermolecular recognition site; other site 517418002058 dimerization interface [polypeptide binding]; other site 517418002059 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 517418002060 putative binding surface; other site 517418002061 active site 517418002062 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 517418002063 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 517418002064 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 517418002065 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 517418002066 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 517418002067 protein binding site [polypeptide binding]; other site 517418002068 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 517418002069 Catalytic dyad [active] 517418002070 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 517418002071 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 517418002072 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 517418002073 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418002074 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418002075 binding surface 517418002076 TPR motif; other site 517418002077 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418002078 binding surface 517418002079 TPR motif; other site 517418002080 TPR repeat; Region: TPR_11; pfam13414 517418002081 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418002082 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418002083 binding surface 517418002084 TPR motif; other site 517418002085 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418002086 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418002087 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 517418002088 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 517418002089 dimer interface [polypeptide binding]; other site 517418002090 phosphorylation site [posttranslational modification] 517418002091 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418002092 ATP binding site [chemical binding]; other site 517418002093 Mg2+ binding site [ion binding]; other site 517418002094 G-X-G motif; other site 517418002095 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 517418002096 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 517418002097 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 517418002098 NAD(P) binding site [chemical binding]; other site 517418002099 putative active site [active] 517418002100 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 517418002101 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 517418002102 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 517418002103 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 517418002104 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 517418002105 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 517418002106 dimer interface [polypeptide binding]; other site 517418002107 active site 517418002108 citrylCoA binding site [chemical binding]; other site 517418002109 NADH binding [chemical binding]; other site 517418002110 cationic pore residues; other site 517418002111 oxalacetate/citrate binding site [chemical binding]; other site 517418002112 coenzyme A binding site [chemical binding]; other site 517418002113 catalytic triad [active] 517418002114 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 517418002115 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 517418002116 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 517418002117 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 517418002118 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 517418002119 CcmE; Region: CcmE; cl00994 517418002120 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 517418002121 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 517418002122 DNA protecting protein DprA; Region: dprA; TIGR00732 517418002123 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 517418002124 active site residue [active] 517418002125 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 517418002126 nudix motif; other site 517418002127 Predicted permeases [General function prediction only]; Region: COG0795 517418002128 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 517418002129 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 517418002130 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 517418002131 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 517418002132 dimer interface [polypeptide binding]; other site 517418002133 ADP-ribose binding site [chemical binding]; other site 517418002134 active site 517418002135 nudix motif; other site 517418002136 metal binding site [ion binding]; metal-binding site 517418002137 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 517418002138 putative active site [active] 517418002139 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 517418002140 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 517418002141 catalytic triad [active] 517418002142 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 517418002143 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 517418002144 V4R domain; Region: V4R; cl15268 517418002145 PUCC protein; Region: PUCC; pfam03209 517418002146 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 517418002147 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 517418002148 pantothenate kinase; Reviewed; Region: PRK13320 517418002149 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 517418002150 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 517418002151 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 517418002152 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 517418002153 NAD binding site [chemical binding]; other site 517418002154 homotetramer interface [polypeptide binding]; other site 517418002155 homodimer interface [polypeptide binding]; other site 517418002156 substrate binding site [chemical binding]; other site 517418002157 active site 517418002158 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 517418002159 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 517418002160 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 517418002161 DTAP/Switch II; other site 517418002162 Switch I; other site 517418002163 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 517418002164 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 517418002165 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 517418002166 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 517418002167 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 517418002168 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 517418002169 Outer membrane efflux protein; Region: OEP; pfam02321 517418002170 Outer membrane efflux protein; Region: OEP; pfam02321 517418002171 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 517418002172 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 517418002173 HlyD family secretion protein; Region: HlyD_3; pfam13437 517418002174 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 517418002175 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 517418002176 Cytochrome c; Region: Cytochrom_C; cl11414 517418002177 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 517418002178 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 517418002179 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 517418002180 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 517418002181 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 517418002182 DsrC like protein; Region: DsrC; pfam04358 517418002183 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 517418002184 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 517418002185 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 517418002186 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 517418002187 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 517418002188 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 517418002189 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 517418002190 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 517418002191 dimer interface [polypeptide binding]; other site 517418002192 ssDNA binding site [nucleotide binding]; other site 517418002193 tetramer (dimer of dimers) interface [polypeptide binding]; other site 517418002194 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 517418002195 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 517418002196 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 517418002197 Walker A/P-loop; other site 517418002198 ATP binding site [chemical binding]; other site 517418002199 Q-loop/lid; other site 517418002200 ABC transporter signature motif; other site 517418002201 Walker B; other site 517418002202 D-loop; other site 517418002203 H-loop/switch region; other site 517418002204 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 517418002205 OPT oligopeptide transporter protein; Region: OPT; cl14607 517418002206 TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329 517418002207 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 517418002208 dimer interface [polypeptide binding]; other site 517418002209 phosphorylation site [posttranslational modification] 517418002210 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418002211 ATP binding site [chemical binding]; other site 517418002212 Mg2+ binding site [ion binding]; other site 517418002213 G-X-G motif; other site 517418002214 Response regulator receiver domain; Region: Response_reg; pfam00072 517418002215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418002216 active site 517418002217 phosphorylation site [posttranslational modification] 517418002218 intermolecular recognition site; other site 517418002219 dimerization interface [polypeptide binding]; other site 517418002220 purine nucleoside phosphorylase; Provisional; Region: PRK08202 517418002221 alanine aminotransferase; Validated; Region: PRK08363 517418002222 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 517418002223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 517418002224 homodimer interface [polypeptide binding]; other site 517418002225 catalytic residue [active] 517418002226 DivIVA protein; Region: DivIVA; pfam05103 517418002227 DivIVA domain; Region: DivI1A_domain; TIGR03544 517418002228 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 517418002229 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 517418002230 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 517418002231 active site 517418002232 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 517418002233 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 517418002234 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 517418002235 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 517418002236 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 517418002237 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 517418002238 PA/protease or protease-like domain interface [polypeptide binding]; other site 517418002239 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 517418002240 Peptidase family M28; Region: Peptidase_M28; pfam04389 517418002241 metal binding site [ion binding]; metal-binding site 517418002242 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 517418002243 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 517418002244 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 517418002245 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 517418002246 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 517418002247 NAD(P) binding site [chemical binding]; other site 517418002248 homotetramer interface [polypeptide binding]; other site 517418002249 homodimer interface [polypeptide binding]; other site 517418002250 active site 517418002251 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 517418002252 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 517418002253 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 517418002254 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 517418002255 dimer interface [polypeptide binding]; other site 517418002256 active site 517418002257 CoA binding pocket [chemical binding]; other site 517418002258 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 517418002259 G1 box; other site 517418002260 GTP/Mg2+ binding site [chemical binding]; other site 517418002261 G2 box; other site 517418002262 Switch I region; other site 517418002263 G3 box; other site 517418002264 Switch II region; other site 517418002265 G4 box; other site 517418002266 G5 box; other site 517418002267 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 517418002268 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 517418002269 Predicted membrane protein (DUF2214); Region: DUF2214; cl01427 517418002270 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 517418002271 dimerization domain swap beta strand [polypeptide binding]; other site 517418002272 regulatory protein interface [polypeptide binding]; other site 517418002273 active site 517418002274 regulatory phosphorylation site [posttranslational modification]; other site 517418002275 GTPase CgtA; Reviewed; Region: obgE; PRK12299 517418002276 GTP1/OBG; Region: GTP1_OBG; pfam01018 517418002277 Obg GTPase; Region: Obg; cd01898 517418002278 G1 box; other site 517418002279 GTP/Mg2+ binding site [chemical binding]; other site 517418002280 Switch I region; other site 517418002281 G2 box; other site 517418002282 G3 box; other site 517418002283 Switch II region; other site 517418002284 G4 box; other site 517418002285 G5 box; other site 517418002286 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 517418002287 ATP cone domain; Region: ATP-cone; pfam03477 517418002288 Class III ribonucleotide reductase; Region: RNR_III; cd01675 517418002289 effector binding site; other site 517418002290 active site 517418002291 Zn binding site [ion binding]; other site 517418002292 glycine loop; other site 517418002293 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 517418002294 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 517418002295 FeS/SAM binding site; other site 517418002296 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 517418002297 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 517418002298 dimer interface [polypeptide binding]; other site 517418002299 active site 517418002300 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 517418002301 GAF domain; Region: GAF; pfam01590 517418002302 PAS domain S-box; Region: sensory_box; TIGR00229 517418002303 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418002304 putative active site [active] 517418002305 heme pocket [chemical binding]; other site 517418002306 PAS fold; Region: PAS_4; pfam08448 517418002307 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418002308 PAS fold; Region: PAS_3; pfam08447 517418002309 putative active site [active] 517418002310 heme pocket [chemical binding]; other site 517418002311 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 517418002312 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 517418002313 histidine kinase; Provisional; Region: PRK13557 517418002314 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418002315 putative active site [active] 517418002316 heme pocket [chemical binding]; other site 517418002317 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 517418002318 dimer interface [polypeptide binding]; other site 517418002319 phosphorylation site [posttranslational modification] 517418002320 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418002321 ATP binding site [chemical binding]; other site 517418002322 Mg2+ binding site [ion binding]; other site 517418002323 G-X-G motif; other site 517418002324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418002325 active site 517418002326 phosphorylation site [posttranslational modification] 517418002327 intermolecular recognition site; other site 517418002328 dimerization interface [polypeptide binding]; other site 517418002329 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 517418002330 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 517418002331 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 517418002332 putative active site [active] 517418002333 catalytic residue [active] 517418002334 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 517418002335 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 517418002336 G1 box; other site 517418002337 GTP/Mg2+ binding site [chemical binding]; other site 517418002338 G2 box; other site 517418002339 Switch I region; other site 517418002340 G3 box; other site 517418002341 Switch II region; other site 517418002342 G4 box; other site 517418002343 G5 box; other site 517418002344 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 517418002345 MoxR-like ATPases [General function prediction only]; Region: COG0714 517418002346 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 517418002347 Walker A motif; other site 517418002348 ATP binding site [chemical binding]; other site 517418002349 Walker B motif; other site 517418002350 arginine finger; other site 517418002351 AP2 domain; Region: AP2; pfam00847 517418002352 pyruvate phosphate dikinase; Provisional; Region: PRK09279 517418002353 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 517418002354 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 517418002355 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 517418002356 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 517418002357 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 517418002358 TM-ABC transporter signature motif; other site 517418002359 Clp protease; Region: CLP_protease; pfam00574 517418002360 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 517418002361 oligomer interface [polypeptide binding]; other site 517418002362 active site residues [active] 517418002363 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418002364 PAS fold; Region: PAS_3; pfam08447 517418002365 putative active site [active] 517418002366 heme pocket [chemical binding]; other site 517418002367 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 517418002368 dimer interface [polypeptide binding]; other site 517418002369 phosphorylation site [posttranslational modification] 517418002370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418002371 ATP binding site [chemical binding]; other site 517418002372 G-X-G motif; other site 517418002373 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 517418002374 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 517418002375 IHF - DNA interface [nucleotide binding]; other site 517418002376 IHF dimer interface [polypeptide binding]; other site 517418002377 elongation factor P; Validated; Region: PRK00529 517418002378 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 517418002379 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 517418002380 RNA binding site [nucleotide binding]; other site 517418002381 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 517418002382 RNA binding site [nucleotide binding]; other site 517418002383 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 517418002384 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 517418002385 carboxyltransferase (CT) interaction site; other site 517418002386 biotinylation site [posttranslational modification]; other site 517418002387 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 517418002388 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 517418002389 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 517418002390 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 517418002391 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 517418002392 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 517418002393 dimer interface [polypeptide binding]; other site 517418002394 anticodon binding site; other site 517418002395 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 517418002396 homodimer interface [polypeptide binding]; other site 517418002397 motif 1; other site 517418002398 active site 517418002399 motif 2; other site 517418002400 GAD domain; Region: GAD; pfam02938 517418002401 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 517418002402 active site 517418002403 motif 3; other site 517418002404 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 517418002405 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 517418002406 putative active site [active] 517418002407 catalytic triad [active] 517418002408 putative dimer interface [polypeptide binding]; other site 517418002409 Bacteriochlorophyll A protein; Region: BChl_A; pfam02327 517418002410 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 517418002411 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 517418002412 active site 517418002413 dimer interface [polypeptide binding]; other site 517418002414 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 517418002415 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 517418002416 active site 517418002417 FMN binding site [chemical binding]; other site 517418002418 substrate binding site [chemical binding]; other site 517418002419 3Fe-4S cluster binding site [ion binding]; other site 517418002420 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 517418002421 domain_subunit interface; other site 517418002422 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 517418002423 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 517418002424 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 517418002425 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 517418002426 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 517418002427 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 517418002428 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 517418002429 trimer interface [polypeptide binding]; other site 517418002430 active site 517418002431 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 517418002432 DNA-binding site [nucleotide binding]; DNA binding site 517418002433 RNA-binding motif; other site 517418002434 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 517418002435 EamA-like transporter family; Region: EamA; pfam00892 517418002436 Molybdopterin converting factor, small subunit [Coenzyme metabolism]; Region: MoaD; COG1977 517418002437 charged pocket; other site 517418002438 hydrophobic patch; other site 517418002439 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 517418002440 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 517418002441 ATP binding site [chemical binding]; other site 517418002442 substrate interface [chemical binding]; other site 517418002443 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 517418002444 active site residue [active] 517418002445 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 517418002446 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 517418002447 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 517418002448 active site 517418002449 Int/Topo IB signature motif; other site 517418002450 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 517418002451 30S subunit binding site; other site 517418002452 Predicted membrane protein [Function unknown]; Region: COG2119 517418002453 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 517418002454 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14616 517418002455 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 517418002456 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 517418002457 geranylgeranylglyceryl phosphate synthase-like protein; Reviewed; Region: PRK04169 517418002458 PcrB family; Region: PcrB; pfam01884 517418002459 phosphate binding site [ion binding]; other site 517418002460 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 517418002461 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 517418002462 Dynamin family; Region: Dynamin_N; pfam00350 517418002463 G1 box; other site 517418002464 Walker A/P-loop; other site 517418002465 GTP/Mg2+ binding site [chemical binding]; other site 517418002466 ATP binding site [chemical binding]; other site 517418002467 G2 box; other site 517418002468 Switch I region; other site 517418002469 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 517418002470 G3 box; other site 517418002471 Switch II region; other site 517418002472 G4 box; other site 517418002473 Uncharacterized conserved protein [Function unknown]; Region: COG4198 517418002474 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 517418002475 ScpA/B protein; Region: ScpA_ScpB; cl00598 517418002476 Response regulator receiver domain; Region: Response_reg; pfam00072 517418002477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418002478 active site 517418002479 phosphorylation site [posttranslational modification] 517418002480 intermolecular recognition site; other site 517418002481 dimerization interface [polypeptide binding]; other site 517418002482 Response regulator receiver domain; Region: Response_reg; pfam00072 517418002483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418002484 active site 517418002485 phosphorylation site [posttranslational modification] 517418002486 intermolecular recognition site; other site 517418002487 dimerization interface [polypeptide binding]; other site 517418002488 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 517418002489 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 517418002490 dimer interface [polypeptide binding]; other site 517418002491 phosphorylation site [posttranslational modification] 517418002492 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418002493 ATP binding site [chemical binding]; other site 517418002494 Mg2+ binding site [ion binding]; other site 517418002495 G-X-G motif; other site 517418002496 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 517418002497 TIGR01777 family protein; Region: yfcH 517418002498 putative NAD(P) binding site [chemical binding]; other site 517418002499 putative active site [active] 517418002500 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 517418002501 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418002502 ATP binding site [chemical binding]; other site 517418002503 Mg2+ binding site [ion binding]; other site 517418002504 G-X-G motif; other site 517418002505 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 517418002506 ATP binding site [chemical binding]; other site 517418002507 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 517418002508 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 517418002509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418002510 active site 517418002511 phosphorylation site [posttranslational modification] 517418002512 intermolecular recognition site; other site 517418002513 dimerization interface [polypeptide binding]; other site 517418002514 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 517418002515 Walker A motif; other site 517418002516 ATP binding site [chemical binding]; other site 517418002517 Walker B motif; other site 517418002518 arginine finger; other site 517418002519 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 517418002520 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 517418002521 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 517418002522 DNA binding site [nucleotide binding] 517418002523 active site 517418002524 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 517418002525 classical (c) SDRs; Region: SDR_c; cd05233 517418002526 NAD(P) binding site [chemical binding]; other site 517418002527 active site 517418002528 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 517418002529 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 517418002530 heterodimer interface [polypeptide binding]; other site 517418002531 active site 517418002532 FMN binding site [chemical binding]; other site 517418002533 homodimer interface [polypeptide binding]; other site 517418002534 substrate binding site [chemical binding]; other site 517418002535 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 517418002536 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 517418002537 catalytic residues [active] 517418002538 NurA domain; Region: NurA; pfam09376 517418002539 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 517418002540 universal stress protein UspE; Provisional; Region: PRK11175 517418002541 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 517418002542 Ligand Binding Site [chemical binding]; other site 517418002543 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 517418002544 Ligand Binding Site [chemical binding]; other site 517418002545 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 517418002546 Haem-binding domain; Region: Haem_bd; pfam14376 517418002547 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 517418002548 Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739 517418002549 putative active site [active] 517418002550 putative FMN binding site [chemical binding]; other site 517418002551 putative substrate binding site [chemical binding]; other site 517418002552 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 517418002553 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 517418002554 dimer interface [polypeptide binding]; other site 517418002555 PYR/PP interface [polypeptide binding]; other site 517418002556 TPP binding site [chemical binding]; other site 517418002557 substrate binding site [chemical binding]; other site 517418002558 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 517418002559 Domain of unknown function; Region: EKR; pfam10371 517418002560 4Fe-4S binding domain; Region: Fer4_6; pfam12837 517418002561 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 517418002562 TPP-binding site [chemical binding]; other site 517418002563 dimer interface [polypeptide binding]; other site 517418002564 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418002565 PAS domain; Region: PAS_9; pfam13426 517418002566 putative active site [active] 517418002567 heme pocket [chemical binding]; other site 517418002568 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 517418002569 FeS/SAM binding site; other site 517418002570 Radical SAM superfamily; Region: Radical_SAM; pfam04055 517418002571 Divergent AAA domain; Region: AAA_4; pfam04326 517418002572 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 517418002573 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 517418002574 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 517418002575 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 517418002576 Peptidase family M50; Region: Peptidase_M50; pfam02163 517418002577 active site 517418002578 putative substrate binding region [chemical binding]; other site 517418002579 TPR repeat; Region: TPR_11; pfam13414 517418002580 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418002581 TPR motif; other site 517418002582 binding surface 517418002583 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 517418002584 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 517418002585 active site 517418002586 HIGH motif; other site 517418002587 nucleotide binding site [chemical binding]; other site 517418002588 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 517418002589 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 517418002590 active site 517418002591 KMSKS motif; other site 517418002592 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 517418002593 tRNA binding surface [nucleotide binding]; other site 517418002594 anticodon binding site; other site 517418002595 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 517418002596 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 517418002597 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 517418002598 active site 517418002599 tetramer interface [polypeptide binding]; other site 517418002600 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 517418002601 active site 517418002602 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 517418002603 Domain of unknown function DUF21; Region: DUF21; pfam01595 517418002604 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 517418002605 Transporter associated domain; Region: CorC_HlyC; smart01091 517418002606 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 517418002607 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 517418002608 FecR protein; Region: FecR; pfam04773 517418002609 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 517418002610 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 517418002611 CTP synthetase; Validated; Region: pyrG; PRK05380 517418002612 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 517418002613 Catalytic site [active] 517418002614 active site 517418002615 UTP binding site [chemical binding]; other site 517418002616 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 517418002617 active site 517418002618 putative oxyanion hole; other site 517418002619 catalytic triad [active] 517418002620 DnaJ domain; Region: DnaJ; pfam00226 517418002621 FOG: WD40 repeat [General function prediction only]; Region: COG2319 517418002622 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 517418002623 structural tetrad; other site 517418002624 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 517418002625 putative hydrolase; Provisional; Region: PRK02113 517418002626 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 517418002627 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 517418002628 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 517418002629 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 517418002630 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 517418002631 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 517418002632 starch-binding site 2 [chemical binding]; other site 517418002633 starch-binding site 1 [chemical binding]; other site 517418002634 Protein of unknown function (DUF456); Region: DUF456; pfam04306 517418002635 GTPase RsgA; Reviewed; Region: PRK01889 517418002636 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 517418002637 RNA binding site [nucleotide binding]; other site 517418002638 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 517418002639 GTPase/Zn-binding domain interface [polypeptide binding]; other site 517418002640 GTP/Mg2+ binding site [chemical binding]; other site 517418002641 G4 box; other site 517418002642 G5 box; other site 517418002643 G1 box; other site 517418002644 Switch I region; other site 517418002645 G2 box; other site 517418002646 G3 box; other site 517418002647 Switch II region; other site 517418002648 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 517418002649 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 517418002650 FeS/SAM binding site; other site 517418002651 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 517418002652 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 517418002653 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 517418002654 active site 517418002655 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 517418002656 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 517418002657 nucleotide binding site [chemical binding]; other site 517418002658 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 517418002659 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 517418002660 S-adenosylmethionine binding site [chemical binding]; other site 517418002661 Helix-turn-helix domain; Region: HTH_18; pfam12833 517418002662 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 517418002663 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 517418002664 clavulanic acid dehydrogenase (CAD), classical (c) SDR; Region: CAD_SDR_c; cd08934 517418002665 NADP binding site [chemical binding]; other site 517418002666 homotetramer interface [polypeptide binding]; other site 517418002667 homodimer interface [polypeptide binding]; other site 517418002668 active site 517418002669 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 517418002670 Phosphoglycerate kinase; Region: PGK; pfam00162 517418002671 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 517418002672 substrate binding site [chemical binding]; other site 517418002673 hinge regions; other site 517418002674 ADP binding site [chemical binding]; other site 517418002675 catalytic site [active] 517418002676 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418002677 PAS domain; Region: PAS_9; pfam13426 517418002678 putative active site [active] 517418002679 heme pocket [chemical binding]; other site 517418002680 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 517418002681 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418002682 putative active site [active] 517418002683 heme pocket [chemical binding]; other site 517418002684 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418002685 putative active site [active] 517418002686 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 517418002687 heme pocket [chemical binding]; other site 517418002688 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418002689 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 517418002690 putative active site [active] 517418002691 heme pocket [chemical binding]; other site 517418002692 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418002693 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 517418002694 putative active site [active] 517418002695 heme pocket [chemical binding]; other site 517418002696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418002697 ATP binding site [chemical binding]; other site 517418002698 Mg2+ binding site [ion binding]; other site 517418002699 G-X-G motif; other site 517418002700 Response regulator receiver domain; Region: Response_reg; pfam00072 517418002701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418002702 active site 517418002703 phosphorylation site [posttranslational modification] 517418002704 intermolecular recognition site; other site 517418002705 dimerization interface [polypeptide binding]; other site 517418002706 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 517418002707 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 517418002708 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 517418002709 dimer interface [polypeptide binding]; other site 517418002710 active site 517418002711 metal binding site [ion binding]; metal-binding site 517418002712 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 517418002713 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 517418002714 active site 517418002715 catalytic tetrad [active] 517418002716 Helix-turn-helix domain; Region: HTH_18; pfam12833 517418002717 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 517418002718 OstA-like protein; Region: OstA_2; pfam13100 517418002719 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 517418002720 active site 517418002721 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 517418002722 homodimer interface [polypeptide binding]; other site 517418002723 PEGA domain; Region: PEGA; pfam08308 517418002724 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 517418002725 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 517418002726 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 517418002727 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 517418002728 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 517418002729 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 517418002730 catalytic triad [active] 517418002731 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 517418002732 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 517418002733 FMN binding site [chemical binding]; other site 517418002734 active site 517418002735 catalytic residues [active] 517418002736 substrate binding site [chemical binding]; other site 517418002737 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 517418002738 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 517418002739 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418002740 TPR repeat; Region: TPR_11; pfam13414 517418002741 binding surface 517418002742 TPR motif; other site 517418002743 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 517418002744 nucleotide binding site/active site [active] 517418002745 HIT family signature motif; other site 517418002746 catalytic residue [active] 517418002747 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 517418002748 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 517418002749 metal binding site [ion binding]; metal-binding site 517418002750 active site 517418002751 I-site; other site 517418002752 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 517418002753 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 517418002754 substrate binding site [chemical binding]; other site 517418002755 hexamer interface [polypeptide binding]; other site 517418002756 metal binding site [ion binding]; metal-binding site 517418002757 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 517418002758 Fic family protein [Function unknown]; Region: COG3177 517418002759 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 517418002760 Fic/DOC family; Region: Fic; pfam02661 517418002761 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 517418002762 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 517418002763 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 517418002764 trmE is a tRNA modification GTPase; Region: trmE; cd04164 517418002765 G1 box; other site 517418002766 GTP/Mg2+ binding site [chemical binding]; other site 517418002767 Switch I region; other site 517418002768 G2 box; other site 517418002769 Switch II region; other site 517418002770 G3 box; other site 517418002771 G4 box; other site 517418002772 G5 box; other site 517418002773 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 517418002774 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 517418002775 homopentamer interface [polypeptide binding]; other site 517418002776 active site 517418002777 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 517418002778 dimer interface [polypeptide binding]; other site 517418002779 active site 517418002780 PIF1-like helicase; Region: PIF1; pfam05970 517418002781 AAA domain; Region: AAA_30; pfam13604 517418002782 Family description; Region: UvrD_C_2; pfam13538 517418002783 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 517418002784 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 517418002785 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 517418002786 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 517418002787 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 517418002788 FeS/SAM binding site; other site 517418002789 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 517418002790 FOG: WD40 repeat [General function prediction only]; Region: COG2319 517418002791 structural tetrad; other site 517418002792 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 517418002793 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 517418002794 putative active site [active] 517418002795 metal binding site [ion binding]; metal-binding site 517418002796 homodimer binding site [polypeptide binding]; other site 517418002797 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 517418002798 chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014 517418002799 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 517418002800 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 517418002801 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 517418002802 Walker A/P-loop; other site 517418002803 ATP binding site [chemical binding]; other site 517418002804 Q-loop/lid; other site 517418002805 ABC transporter signature motif; other site 517418002806 Walker B; other site 517418002807 D-loop; other site 517418002808 H-loop/switch region; other site 517418002809 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 517418002810 YceG-like family; Region: YceG; pfam02618 517418002811 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 517418002812 dimerization interface [polypeptide binding]; other site 517418002813 Chorismate mutase type II; Region: CM_2; smart00830 517418002814 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 517418002815 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 517418002816 YacP-like NYN domain; Region: NYN_YacP; cl01491 517418002817 MraW methylase family; Region: Methyltransf_5; cl17771 517418002818 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 517418002819 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 517418002820 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 517418002821 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 517418002822 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 517418002823 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 517418002824 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 517418002825 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 517418002826 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 517418002827 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 517418002828 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 517418002829 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 517418002830 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 517418002831 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 517418002832 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 517418002833 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 517418002834 Mg++ binding site [ion binding]; other site 517418002835 putative catalytic motif [active] 517418002836 putative substrate binding site [chemical binding]; other site 517418002837 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 517418002838 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 517418002839 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 517418002840 cell division protein FtsW; Region: ftsW; TIGR02614 517418002841 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 517418002842 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 517418002843 active site 517418002844 homodimer interface [polypeptide binding]; other site 517418002845 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 517418002846 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 517418002847 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 517418002848 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 517418002849 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 517418002850 catalytic motif [active] 517418002851 Catalytic residue [active] 517418002852 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 517418002853 FAD binding domain; Region: FAD_binding_4; pfam01565 517418002854 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 517418002855 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 517418002856 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 517418002857 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 517418002858 nucleotide binding site [chemical binding]; other site 517418002859 Cell division protein FtsA; Region: FtsA; pfam14450 517418002860 cell division protein FtsZ; Validated; Region: PRK09330 517418002861 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 517418002862 nucleotide binding site [chemical binding]; other site 517418002863 SulA interaction site; other site 517418002864 H+ Antiporter protein; Region: 2A0121; TIGR00900 517418002865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 517418002866 putative substrate translocation pore; other site 517418002867 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 517418002868 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 517418002869 ligand binding site [chemical binding]; other site 517418002870 flexible hinge region; other site 517418002871 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 517418002872 DNA polymerase III subunit beta; Provisional; Region: PRK14941 517418002873 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 517418002874 putative DNA binding surface [nucleotide binding]; other site 517418002875 dimer interface [polypeptide binding]; other site 517418002876 beta-clamp/clamp loader binding surface; other site 517418002877 beta-clamp/translesion DNA polymerase binding surface; other site 517418002878 recombination protein F; Reviewed; Region: recF; PRK00064 517418002879 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 517418002880 Walker A/P-loop; other site 517418002881 ATP binding site [chemical binding]; other site 517418002882 Q-loop/lid; other site 517418002883 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 517418002884 ABC transporter signature motif; other site 517418002885 Walker B; other site 517418002886 D-loop; other site 517418002887 H-loop/switch region; other site 517418002888 Protein of unknown function (DUF721); Region: DUF721; pfam05258 517418002889 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 517418002890 Predicted transcriptional regulator [Transcription]; Region: COG2944 517418002891 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 517418002892 non-specific DNA binding site [nucleotide binding]; other site 517418002893 salt bridge; other site 517418002894 sequence-specific DNA binding site [nucleotide binding]; other site 517418002895 Protein of unknown function (DUF1044); Region: DUF1044; pfam06296 517418002896 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 517418002897 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 517418002898 active site 517418002899 substrate binding site [chemical binding]; other site 517418002900 coenzyme B12 binding site [chemical binding]; other site 517418002901 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 517418002902 B12 binding site [chemical binding]; other site 517418002903 cobalt ligand [ion binding]; other site 517418002904 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 517418002905 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 517418002906 heterodimer interface [polypeptide binding]; other site 517418002907 substrate interaction site [chemical binding]; other site 517418002908 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 517418002909 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 517418002910 tetramer interfaces [polypeptide binding]; other site 517418002911 binuclear metal-binding site [ion binding]; other site 517418002912 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 517418002913 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 517418002914 MutS domain III; Region: MutS_III; pfam05192 517418002915 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 517418002916 Walker A/P-loop; other site 517418002917 ATP binding site [chemical binding]; other site 517418002918 Q-loop/lid; other site 517418002919 ABC transporter signature motif; other site 517418002920 Walker B; other site 517418002921 D-loop; other site 517418002922 H-loop/switch region; other site 517418002923 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 517418002924 Smr domain; Region: Smr; pfam01713 517418002925 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 517418002926 Ligand Binding Site [chemical binding]; other site 517418002927 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 517418002928 Ligand Binding Site [chemical binding]; other site 517418002929 DEAD-like helicases superfamily; Region: DEXDc; smart00487 517418002930 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 517418002931 ATP binding site [chemical binding]; other site 517418002932 putative Mg++ binding site [ion binding]; other site 517418002933 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 517418002934 nucleotide binding region [chemical binding]; other site 517418002935 ATP-binding site [chemical binding]; other site 517418002936 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 517418002937 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 517418002938 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 517418002939 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 517418002940 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like2_exo; cd05785 517418002941 DNA polymerase type-B family; Region: POLBc; smart00486 517418002942 active site 517418002943 catalytic site [active] 517418002944 substrate binding site [chemical binding]; other site 517418002945 DNA polymerase family B; Region: DNA_pol_B; pfam00136 517418002946 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 517418002947 active site 517418002948 metal-binding site 517418002949 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 517418002950 bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604 517418002951 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 517418002952 trimer interface [polypeptide binding]; other site 517418002953 dimer interface [polypeptide binding]; other site 517418002954 putative active site [active] 517418002955 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 517418002956 MPT binding site; other site 517418002957 trimer interface [polypeptide binding]; other site 517418002958 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 517418002959 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 517418002960 dimer interface [polypeptide binding]; other site 517418002961 putative functional site; other site 517418002962 putative MPT binding site; other site 517418002963 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 517418002964 Mechanosensitive ion channel; Region: MS_channel; pfam00924 517418002965 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 517418002966 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 517418002967 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 517418002968 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 517418002969 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 517418002970 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 517418002971 pyridoxal 5'-phosphate binding site [chemical binding]; other site 517418002972 catalytic residue [active] 517418002973 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 517418002974 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 517418002975 dimer interface [polypeptide binding]; other site 517418002976 phosphorylation site [posttranslational modification] 517418002977 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418002978 ATP binding site [chemical binding]; other site 517418002979 Mg2+ binding site [ion binding]; other site 517418002980 G-X-G motif; other site 517418002981 TPR repeat; Region: TPR_11; pfam13414 517418002982 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418002983 binding surface 517418002984 TPR motif; other site 517418002985 homoserine kinase; Provisional; Region: PRK01212 517418002986 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 517418002987 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 517418002988 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 517418002989 beta subunit interaction interface [polypeptide binding]; other site 517418002990 Walker A motif; other site 517418002991 ATP binding site [chemical binding]; other site 517418002992 Walker B motif; other site 517418002993 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 517418002994 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 517418002995 core domain interface [polypeptide binding]; other site 517418002996 delta subunit interface [polypeptide binding]; other site 517418002997 epsilon subunit interface [polypeptide binding]; other site 517418002998 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 517418002999 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 517418003000 FeS/SAM binding site; other site 517418003001 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 517418003002 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 517418003003 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 517418003004 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 517418003005 Substrate binding site; other site 517418003006 metal-binding site 517418003007 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 517418003008 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 517418003009 glycogen synthase; Provisional; Region: glgA; PRK00654 517418003010 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 517418003011 ADP-binding pocket [chemical binding]; other site 517418003012 homodimer interface [polypeptide binding]; other site 517418003013 flavoprotein, HI0933 family; Region: TIGR00275 517418003014 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 517418003015 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 517418003016 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 517418003017 FeS/SAM binding site; other site 517418003018 HemN C-terminal domain; Region: HemN_C; pfam06969 517418003019 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 517418003020 chaperone protein HscA; Provisional; Region: hscA; PRK05183 517418003021 nucleotide binding site [chemical binding]; other site 517418003022 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 517418003023 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 517418003024 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 517418003025 active site 517418003026 DNA binding site [nucleotide binding] 517418003027 Int/Topo IB signature motif; other site 517418003028 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 517418003029 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 517418003030 pyridoxal 5'-phosphate binding site [chemical binding]; other site 517418003031 catalytic residue [active] 517418003032 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 517418003033 active site residue [active] 517418003034 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 517418003035 sequence-specific DNA binding site [nucleotide binding]; other site 517418003036 salt bridge; other site 517418003037 LexA repressor; Provisional; Region: PRK12423 517418003038 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 517418003039 Catalytic site [active] 517418003040 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 517418003041 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 517418003042 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 517418003043 dimer interface [polypeptide binding]; other site 517418003044 phosphorylation site [posttranslational modification] 517418003045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418003046 ATP binding site [chemical binding]; other site 517418003047 Mg2+ binding site [ion binding]; other site 517418003048 G-X-G motif; other site 517418003049 Response regulator receiver domain; Region: Response_reg; pfam00072 517418003050 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418003051 active site 517418003052 phosphorylation site [posttranslational modification] 517418003053 intermolecular recognition site; other site 517418003054 dimerization interface [polypeptide binding]; other site 517418003055 Response regulator receiver domain; Region: Response_reg; pfam00072 517418003056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418003057 active site 517418003058 phosphorylation site [posttranslational modification] 517418003059 intermolecular recognition site; other site 517418003060 dimerization interface [polypeptide binding]; other site 517418003061 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 517418003062 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 517418003063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 517418003064 putative substrate translocation pore; other site 517418003065 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 517418003066 Domain of unknown function (DUF4071); Region: DUF4071; pfam13281 517418003067 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 517418003068 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 517418003069 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 517418003070 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 517418003071 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 517418003072 putative NAD(P) binding site [chemical binding]; other site 517418003073 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 517418003074 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 517418003075 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 517418003076 N-terminal catalytic domain of 4-alpha-glucanotransferase; glycoside hydrolase family 57 (GH57); Region: GH57N_TLGT_like; cd10793 517418003077 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 517418003078 active site 517418003079 catalytic site [active] 517418003080 homodimer interface [polypeptide binding]; other site 517418003081 Lid 1; other site 517418003082 Domain of unknown function (DUF1925); Region: DUF1925; pfam09094 517418003083 Domain of unknown function (DUF1926); Region: DUF1926; pfam09095 517418003084 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 517418003085 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 517418003086 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 517418003087 IHF dimer interface [polypeptide binding]; other site 517418003088 IHF - DNA interface [nucleotide binding]; other site 517418003089 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 517418003090 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 517418003091 active site 517418003092 metal binding site [ion binding]; metal-binding site 517418003093 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 517418003094 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 517418003095 catalytic site [active] 517418003096 G-X2-G-X-G-K; other site 517418003097 hypothetical protein; Provisional; Region: PRK11820 517418003098 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 517418003099 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 517418003100 PBP superfamily domain; Region: PBP_like_2; cl17296 517418003101 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 517418003102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 517418003103 dimer interface [polypeptide binding]; other site 517418003104 conserved gate region; other site 517418003105 putative PBP binding loops; other site 517418003106 ABC-ATPase subunit interface; other site 517418003107 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 517418003108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 517418003109 dimer interface [polypeptide binding]; other site 517418003110 conserved gate region; other site 517418003111 putative PBP binding loops; other site 517418003112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 517418003113 ABC-ATPase subunit interface; other site 517418003114 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 517418003115 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 517418003116 Walker A/P-loop; other site 517418003117 ATP binding site [chemical binding]; other site 517418003118 Q-loop/lid; other site 517418003119 ABC transporter signature motif; other site 517418003120 Walker B; other site 517418003121 D-loop; other site 517418003122 H-loop/switch region; other site 517418003123 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 517418003124 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 517418003125 Walker A/P-loop; other site 517418003126 ATP binding site [chemical binding]; other site 517418003127 Q-loop/lid; other site 517418003128 ABC transporter signature motif; other site 517418003129 Walker B; other site 517418003130 D-loop; other site 517418003131 H-loop/switch region; other site 517418003132 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 517418003133 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 517418003134 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 517418003135 substrate binding site [chemical binding]; other site 517418003136 active site 517418003137 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 517418003138 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 517418003139 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 517418003140 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 517418003141 catalytic loop [active] 517418003142 iron binding site [ion binding]; other site 517418003143 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 517418003144 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 517418003145 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 517418003146 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 517418003147 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 517418003148 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 517418003149 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418003150 binding surface 517418003151 TPR motif; other site 517418003152 flavodoxin FldA; Validated; Region: PRK09267 517418003153 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 517418003154 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 517418003155 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 517418003156 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 517418003157 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 517418003158 FeoA domain; Region: FeoA; pfam04023 517418003159 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 517418003160 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 517418003161 Ligand binding site; other site 517418003162 Putative Catalytic site; other site 517418003163 DXD motif; other site 517418003164 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 517418003165 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 517418003166 active site 517418003167 catalytic site [active] 517418003168 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 517418003169 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 517418003170 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 517418003171 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749 517418003172 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 517418003173 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl01634 517418003174 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 517418003175 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 517418003176 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 517418003177 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 517418003178 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 517418003179 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 517418003180 putative active site; other site 517418003181 catalytic triad [active] 517418003182 putative dimer interface [polypeptide binding]; other site 517418003183 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 517418003184 UbiA prenyltransferase family; Region: UbiA; pfam01040 517418003185 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 517418003186 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 517418003187 active site 517418003188 SAM binding site [chemical binding]; other site 517418003189 homodimer interface [polypeptide binding]; other site 517418003190 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 517418003191 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 517418003192 N-terminal plug; other site 517418003193 ligand-binding site [chemical binding]; other site 517418003194 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 517418003195 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 517418003196 putative PBP binding regions; other site 517418003197 ABC-ATPase subunit interface; other site 517418003198 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 517418003199 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 517418003200 Walker A/P-loop; other site 517418003201 ATP binding site [chemical binding]; other site 517418003202 Q-loop/lid; other site 517418003203 ABC transporter signature motif; other site 517418003204 Walker B; other site 517418003205 D-loop; other site 517418003206 H-loop/switch region; other site 517418003207 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 517418003208 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 517418003209 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 517418003210 putative ligand binding residues [chemical binding]; other site 517418003211 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 517418003212 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 517418003213 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 517418003214 Walker A/P-loop; other site 517418003215 ATP binding site [chemical binding]; other site 517418003216 ABC transporter; Region: ABC_tran; pfam00005 517418003217 Q-loop/lid; other site 517418003218 ABC transporter signature motif; other site 517418003219 Walker B; other site 517418003220 D-loop; other site 517418003221 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 517418003222 hydroxyglutarate oxidase; Provisional; Region: PRK11728 517418003223 glycyl-tRNA synthetase; Provisional; Region: PRK04173 517418003224 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 517418003225 motif 1; other site 517418003226 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 517418003227 active site 517418003228 motif 2; other site 517418003229 motif 3; other site 517418003230 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 517418003231 anticodon binding site; other site 517418003232 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 517418003233 Permease; Region: Permease; pfam02405 517418003234 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 517418003235 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 517418003236 active site 517418003237 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 517418003238 glycyl-tRNA synthetase; Region: PLN02734 517418003239 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 517418003240 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 517418003241 hydrophobic ligand binding site; other site 517418003242 short chain dehydrogenase; Provisional; Region: PRK07326 517418003243 classical (c) SDRs; Region: SDR_c; cd05233 517418003244 NAD(P) binding site [chemical binding]; other site 517418003245 active site 517418003246 BioY family; Region: BioY; pfam02632 517418003247 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 517418003248 phytoene desaturase; Region: crtI_fam; TIGR02734 517418003249 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 517418003250 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 517418003251 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 517418003252 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 517418003253 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 517418003254 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 517418003255 active site 517418003256 catalytic tetrad [active] 517418003257 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 517418003258 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 517418003259 Walker A motif; other site 517418003260 ATP binding site [chemical binding]; other site 517418003261 Walker B motif; other site 517418003262 arginine finger; other site 517418003263 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 517418003264 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 517418003265 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 517418003266 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 517418003267 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 517418003268 Coenzyme A binding pocket [chemical binding]; other site 517418003269 NlpC/P60 family; Region: NLPC_P60; pfam00877 517418003270 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 517418003271 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 517418003272 N-terminal plug; other site 517418003273 ligand-binding site [chemical binding]; other site 517418003274 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 517418003275 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 517418003276 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 517418003277 N-terminal plug; other site 517418003278 ligand-binding site [chemical binding]; other site 517418003279 Domain of unknown function (DUF4374); Region: DUF4374; pfam14298 517418003280 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 517418003281 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 517418003282 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 517418003283 N-terminal plug; other site 517418003284 ligand-binding site [chemical binding]; other site 517418003285 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 517418003286 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 517418003287 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 517418003288 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 517418003289 Cna protein B-type domain; Region: Cna_B_2; pfam13715 517418003290 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 517418003291 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 517418003292 N-terminal plug; other site 517418003293 ligand-binding site [chemical binding]; other site 517418003294 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 517418003295 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 517418003296 EamA-like transporter family; Region: EamA; pfam00892 517418003297 EamA-like transporter family; Region: EamA; pfam00892 517418003298 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 517418003299 S-adenosylmethionine binding site [chemical binding]; other site 517418003300 Methyltransferase domain; Region: Methyltransf_18; pfam12847 517418003301 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 517418003302 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 517418003303 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 517418003304 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 517418003305 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 517418003306 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 517418003307 Walker A/P-loop; other site 517418003308 ATP binding site [chemical binding]; other site 517418003309 Q-loop/lid; other site 517418003310 ABC transporter signature motif; other site 517418003311 Walker B; other site 517418003312 D-loop; other site 517418003313 H-loop/switch region; other site 517418003314 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 517418003315 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 517418003316 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 517418003317 Walker A/P-loop; other site 517418003318 ATP binding site [chemical binding]; other site 517418003319 Q-loop/lid; other site 517418003320 ABC transporter signature motif; other site 517418003321 Walker B; other site 517418003322 D-loop; other site 517418003323 H-loop/switch region; other site 517418003324 Domain of unknown function (DUF4374); Region: DUF4374; pfam14298 517418003325 Cna protein B-type domain; Region: Cna_B_2; pfam13715 517418003326 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 517418003327 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 517418003328 N-terminal plug; other site 517418003329 ligand-binding site [chemical binding]; other site 517418003330 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 517418003331 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 517418003332 Cna protein B-type domain; Region: Cna_B_2; pfam13715 517418003333 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 517418003334 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 517418003335 N-terminal plug; other site 517418003336 ligand-binding site [chemical binding]; other site 517418003337 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 517418003338 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 517418003339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 517418003340 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 517418003341 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 517418003342 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 517418003343 putative active site [active] 517418003344 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 517418003345 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 517418003346 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 517418003347 N-terminal plug; other site 517418003348 ligand-binding site [chemical binding]; other site 517418003349 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 517418003350 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 517418003351 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 517418003352 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 517418003353 Coenzyme A binding pocket [chemical binding]; other site 517418003354 Protein of unknown function DUF262; Region: DUF262; pfam03235 517418003355 Uncharacterized conserved protein [Function unknown]; Region: COG1479 517418003356 Uncharacterized conserved protein [Function unknown]; Region: COG3472 517418003357 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 517418003358 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 517418003359 putative active site [active] 517418003360 metal binding site [ion binding]; metal-binding site 517418003361 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 517418003362 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 517418003363 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 517418003364 toxin interface [polypeptide binding]; other site 517418003365 Zn binding site [ion binding]; other site 517418003366 integron integrase; Region: integrase_gron; TIGR02249 517418003367 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 517418003368 Int/Topo IB signature motif; other site 517418003369 YfjP GTPase; Region: YfjP; cd11383 517418003370 GTP/Mg2+ binding site [chemical binding]; other site 517418003371 Switch I region; other site 517418003372 G2 box; other site 517418003373 Switch II region; other site 517418003374 G3 box; other site 517418003375 G4 box; other site 517418003376 G5 box; other site 517418003377 YfjP GTPase; Region: YfjP; cd11383 517418003378 G1 box; other site 517418003379 GTP/Mg2+ binding site [chemical binding]; other site 517418003380 Switch I region; other site 517418003381 G2 box; other site 517418003382 Switch II region; other site 517418003383 G3 box; other site 517418003384 G4 box; other site 517418003385 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 517418003386 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 517418003387 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 517418003388 putative active site [active] 517418003389 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 517418003390 dimer interface [polypeptide binding]; other site 517418003391 [2Fe-2S] cluster binding site [ion binding]; other site 517418003392 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 517418003393 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 517418003394 FeS/SAM binding site; other site 517418003395 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 517418003396 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 517418003397 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 517418003398 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 517418003399 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 517418003400 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 517418003401 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 517418003402 MoFe protein beta/alpha subunit interactions; other site 517418003403 Beta subunit P cluster binding residues; other site 517418003404 MoFe protein beta subunit/Fe protein contacts; other site 517418003405 MoFe protein dimer/ dimer interactions; other site 517418003406 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 517418003407 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 517418003408 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 517418003409 Nitrogen regulatory protein P-II; Region: P-II; smart00938 517418003410 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 517418003411 Nitrogen regulatory protein P-II; Region: P-II; smart00938 517418003412 nitrogenase reductase; Reviewed; Region: nifH; PRK13235 517418003413 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 517418003414 Nucleotide-binding sites [chemical binding]; other site 517418003415 Walker A motif; other site 517418003416 Switch I region of nucleotide binding site; other site 517418003417 Fe4S4 binding sites [ion binding]; other site 517418003418 Switch II region of nucleotide binding site; other site 517418003419 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 517418003420 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 517418003421 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 517418003422 trimer interface [polypeptide binding]; other site 517418003423 putative metal binding site [ion binding]; other site 517418003424 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 517418003425 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 517418003426 Walker A/P-loop; other site 517418003427 ATP binding site [chemical binding]; other site 517418003428 Q-loop/lid; other site 517418003429 ABC transporter signature motif; other site 517418003430 Walker B; other site 517418003431 D-loop; other site 517418003432 H-loop/switch region; other site 517418003433 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 517418003434 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 517418003435 active site 517418003436 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 517418003437 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 517418003438 active site 517418003439 RIP metalloprotease RseP; Region: TIGR00054 517418003440 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 517418003441 active site 517418003442 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 517418003443 protein binding site [polypeptide binding]; other site 517418003444 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 517418003445 protein binding site [polypeptide binding]; other site 517418003446 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 517418003447 putative substrate binding region [chemical binding]; other site 517418003448 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 517418003449 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 517418003450 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 517418003451 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 517418003452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 517418003453 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 517418003454 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 517418003455 amidase catalytic site [active] 517418003456 Zn binding residues [ion binding]; other site 517418003457 substrate binding site [chemical binding]; other site 517418003458 Bacterial SH3 domain; Region: SH3_3; pfam08239 517418003459 Protein of unknown function (DUF3154); Region: DUF3154; pfam11351 517418003460 enolase; Provisional; Region: eno; PRK00077 517418003461 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 517418003462 dimer interface [polypeptide binding]; other site 517418003463 metal binding site [ion binding]; metal-binding site 517418003464 substrate binding pocket [chemical binding]; other site 517418003465 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 517418003466 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 517418003467 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 517418003468 acyl-activating enzyme (AAE) consensus motif; other site 517418003469 AMP binding site [chemical binding]; other site 517418003470 active site 517418003471 CoA binding site [chemical binding]; other site 517418003472 enoyl-CoA hydratase; Provisional; Region: PRK07658 517418003473 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 517418003474 substrate binding site [chemical binding]; other site 517418003475 oxyanion hole (OAH) forming residues; other site 517418003476 trimer interface [polypeptide binding]; other site 517418003477 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 517418003478 NAD(P) binding site [chemical binding]; other site 517418003479 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 517418003480 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 517418003481 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 517418003482 ligand binding site [chemical binding]; other site 517418003483 flexible hinge region; other site 517418003484 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 517418003485 putative switch regulator; other site 517418003486 non-specific DNA interactions [nucleotide binding]; other site 517418003487 DNA binding site [nucleotide binding] 517418003488 sequence specific DNA binding site [nucleotide binding]; other site 517418003489 putative cAMP binding site [chemical binding]; other site 517418003490 trigger factor; Region: tig; TIGR00115 517418003491 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 517418003492 Helix-turn-helix domain; Region: HTH_17; pfam12728 517418003493 DNA methylase; Region: N6_N4_Mtase; pfam01555 517418003494 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 517418003495 Peptidase family M48; Region: Peptidase_M48; pfam01435 517418003496 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 517418003497 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 517418003498 hybrid cluster protein; Provisional; Region: PRK05290 517418003499 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 517418003500 ACS interaction site; other site 517418003501 CODH interaction site; other site 517418003502 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 517418003503 hybrid metal cluster; other site 517418003504 Membrane protein of unknown function (DUF340); Region: DUF340; cl01028 517418003505 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 517418003506 putative catalytic cysteine [active] 517418003507 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 517418003508 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 517418003509 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 517418003510 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 517418003511 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 517418003512 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 517418003513 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 517418003514 protein-splicing catalytic site; other site 517418003515 thioester formation/cholesterol transfer; other site 517418003516 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 517418003517 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 517418003518 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 517418003519 protein-splicing catalytic site; other site 517418003520 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 517418003521 protein-splicing catalytic site; other site 517418003522 thioester formation/cholesterol transfer; other site 517418003523 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 517418003524 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 517418003525 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 517418003526 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 517418003527 TSCPD domain; Region: TSCPD; pfam12637 517418003528 Sporulation related domain; Region: SPOR; cl10051 517418003529 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 517418003530 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 517418003531 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 517418003532 TrkA-N domain; Region: TrkA_N; pfam02254 517418003533 Hemerythrin; Region: Hemerythrin; cd12107 517418003534 Methyltransferase domain; Region: Methyltransf_26; pfam13659 517418003535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 517418003536 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 517418003537 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 517418003538 putative acyl-acceptor binding pocket; other site 517418003539 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 517418003540 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 517418003541 motif II; other site 517418003542 HPr kinase/phosphorylase; Provisional; Region: PRK05428 517418003543 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 517418003544 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 517418003545 Hpr binding site; other site 517418003546 active site 517418003547 homohexamer subunit interaction site [polypeptide binding]; other site 517418003548 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 517418003549 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 517418003550 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 517418003551 RNA binding surface [nucleotide binding]; other site 517418003552 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 517418003553 active site 517418003554 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418003555 binding surface 517418003556 TPR repeat; Region: TPR_11; pfam13414 517418003557 TPR motif; other site 517418003558 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418003559 binding surface 517418003560 TPR repeat; Region: TPR_11; pfam13414 517418003561 TPR motif; other site 517418003562 Tetratricopeptide repeat; Region: TPR_16; pfam13432 517418003563 TPR repeat; Region: TPR_11; pfam13414 517418003564 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 517418003565 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 517418003566 S-adenosylmethionine binding site [chemical binding]; other site 517418003567 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 517418003568 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 517418003569 RNase E interface [polypeptide binding]; other site 517418003570 trimer interface [polypeptide binding]; other site 517418003571 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 517418003572 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 517418003573 RNase E interface [polypeptide binding]; other site 517418003574 trimer interface [polypeptide binding]; other site 517418003575 active site 517418003576 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 517418003577 putative nucleic acid binding region [nucleotide binding]; other site 517418003578 G-X-X-G motif; other site 517418003579 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 517418003580 RNA binding site [nucleotide binding]; other site 517418003581 domain interface; other site 517418003582 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 517418003583 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 517418003584 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 517418003585 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 517418003586 Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; cl11574 517418003587 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 517418003588 Domain of unknown function DUF21; Region: DUF21; pfam01595 517418003589 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 517418003590 Transporter associated domain; Region: CorC_HlyC; smart01091 517418003591 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 517418003592 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 517418003593 dimer interface [polypeptide binding]; other site 517418003594 ssDNA binding site [nucleotide binding]; other site 517418003595 tetramer (dimer of dimers) interface [polypeptide binding]; other site 517418003596 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 517418003597 S17 interaction site [polypeptide binding]; other site 517418003598 S8 interaction site; other site 517418003599 16S rRNA interaction site [nucleotide binding]; other site 517418003600 streptomycin interaction site [chemical binding]; other site 517418003601 23S rRNA interaction site [nucleotide binding]; other site 517418003602 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 517418003603 30S ribosomal protein S7; Validated; Region: PRK05302 517418003604 elongation factor G; Reviewed; Region: PRK00007 517418003605 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 517418003606 G1 box; other site 517418003607 putative GEF interaction site [polypeptide binding]; other site 517418003608 GTP/Mg2+ binding site [chemical binding]; other site 517418003609 Switch I region; other site 517418003610 G2 box; other site 517418003611 G3 box; other site 517418003612 Switch II region; other site 517418003613 G4 box; other site 517418003614 G5 box; other site 517418003615 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 517418003616 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 517418003617 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 517418003618 elongation factor Tu; Reviewed; Region: PRK00049 517418003619 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 517418003620 G1 box; other site 517418003621 GEF interaction site [polypeptide binding]; other site 517418003622 GTP/Mg2+ binding site [chemical binding]; other site 517418003623 Switch I region; other site 517418003624 G2 box; other site 517418003625 G3 box; other site 517418003626 Switch II region; other site 517418003627 G4 box; other site 517418003628 G5 box; other site 517418003629 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 517418003630 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 517418003631 Antibiotic Binding Site [chemical binding]; other site 517418003632 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 517418003633 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 517418003634 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 517418003635 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 517418003636 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 517418003637 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 517418003638 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 517418003639 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 517418003640 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 517418003641 putative translocon binding site; other site 517418003642 protein-rRNA interface [nucleotide binding]; other site 517418003643 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 517418003644 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 517418003645 G-X-X-G motif; other site 517418003646 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 517418003647 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 517418003648 23S rRNA interface [nucleotide binding]; other site 517418003649 5S rRNA interface [nucleotide binding]; other site 517418003650 putative antibiotic binding site [chemical binding]; other site 517418003651 L25 interface [polypeptide binding]; other site 517418003652 L27 interface [polypeptide binding]; other site 517418003653 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 517418003654 putative translocon interaction site; other site 517418003655 23S rRNA interface [nucleotide binding]; other site 517418003656 signal recognition particle (SRP54) interaction site; other site 517418003657 L23 interface [polypeptide binding]; other site 517418003658 trigger factor interaction site; other site 517418003659 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 517418003660 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 517418003661 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 517418003662 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 517418003663 RNA binding site [nucleotide binding]; other site 517418003664 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 517418003665 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 517418003666 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 517418003667 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 517418003668 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 517418003669 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 517418003670 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 517418003671 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 517418003672 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 517418003673 5S rRNA interface [nucleotide binding]; other site 517418003674 L27 interface [polypeptide binding]; other site 517418003675 23S rRNA interface [nucleotide binding]; other site 517418003676 L5 interface [polypeptide binding]; other site 517418003677 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 517418003678 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 517418003679 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 517418003680 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 517418003681 23S rRNA binding site [nucleotide binding]; other site 517418003682 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 517418003683 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 517418003684 SecY translocase; Region: SecY; pfam00344 517418003685 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 517418003686 rRNA binding site [nucleotide binding]; other site 517418003687 predicted 30S ribosome binding site; other site 517418003688 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 517418003689 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 517418003690 30S ribosomal protein S13; Region: bact_S13; TIGR03631 517418003691 30S ribosomal protein S11; Validated; Region: PRK05309 517418003692 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 517418003693 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 517418003694 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 517418003695 RNA binding surface [nucleotide binding]; other site 517418003696 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 517418003697 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 517418003698 alphaNTD homodimer interface [polypeptide binding]; other site 517418003699 alphaNTD - beta interaction site [polypeptide binding]; other site 517418003700 alphaNTD - beta' interaction site [polypeptide binding]; other site 517418003701 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 517418003702 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 517418003703 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 517418003704 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 517418003705 phosphorylation site [posttranslational modification] 517418003706 dimer interface [polypeptide binding]; other site 517418003707 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418003708 ATP binding site [chemical binding]; other site 517418003709 Mg2+ binding site [ion binding]; other site 517418003710 G-X-G motif; other site 517418003711 GMP synthase; Reviewed; Region: guaA; PRK00074 517418003712 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 517418003713 AMP/PPi binding site [chemical binding]; other site 517418003714 candidate oxyanion hole; other site 517418003715 catalytic triad [active] 517418003716 potential glutamine specificity residues [chemical binding]; other site 517418003717 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 517418003718 ATP Binding subdomain [chemical binding]; other site 517418003719 Ligand Binding sites [chemical binding]; other site 517418003720 Dimerization subdomain; other site 517418003721 Transglycosylase; Region: Transgly; pfam00912 517418003722 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 517418003723 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 517418003724 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 517418003725 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 517418003726 nucleophilic elbow; other site 517418003727 catalytic triad; other site 517418003728 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 517418003729 Methyltransferase domain; Region: Methyltransf_23; pfam13489 517418003730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 517418003731 S-adenosylmethionine binding site [chemical binding]; other site 517418003732 D-alanyl-alanine synthetase A; Provisional; Region: PRK14571 517418003733 ATP-grasp domain; Region: ATP-grasp_4; cl17255 517418003734 Protein of unknown function, DUF486; Region: DUF486; pfam04342 517418003735 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 517418003736 Family description; Region: UvrD_C_2; pfam13538 517418003737 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 517418003738 active site 517418003739 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 517418003740 prephenate dehydrogenase; Validated; Region: PRK08507 517418003741 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 517418003742 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 517418003743 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 517418003744 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 517418003745 NADP binding site [chemical binding]; other site 517418003746 dimer interface [polypeptide binding]; other site 517418003747 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 517418003748 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 517418003749 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 517418003750 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 517418003751 stationary phase survival protein SurE; Provisional; Region: PRK13932 517418003752 UGMP family protein; Validated; Region: PRK09604 517418003753 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 517418003754 Preprotein translocase subunit; Region: YajC; pfam02699 517418003755 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 517418003756 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 517418003757 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 517418003758 catalytic site [active] 517418003759 subunit interface [polypeptide binding]; other site 517418003760 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 517418003761 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 517418003762 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 517418003763 peptide chain release factor 1; Validated; Region: prfA; PRK00591 517418003764 PCRF domain; Region: PCRF; pfam03462 517418003765 RF-1 domain; Region: RF-1; pfam00472 517418003766 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 517418003767 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 517418003768 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 517418003769 Acylphosphatase; Region: Acylphosphatase; pfam00708 517418003770 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 517418003771 HypF finger; Region: zf-HYPF; pfam07503 517418003772 HypF finger; Region: zf-HYPF; pfam07503 517418003773 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 517418003774 MjaII restriction endonuclease; Region: RE_MjaII; pfam09520 517418003775 DNA methylase; Region: N6_N4_Mtase; cl17433 517418003776 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 517418003777 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 517418003778 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 517418003779 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 517418003780 PYR/PP interface [polypeptide binding]; other site 517418003781 dimer interface [polypeptide binding]; other site 517418003782 TPP binding site [chemical binding]; other site 517418003783 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 517418003784 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 517418003785 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 517418003786 active site 517418003787 substrate binding site [chemical binding]; other site 517418003788 metal binding site [ion binding]; metal-binding site 517418003789 hypothetical protein; Provisional; Region: PRK14621 517418003790 recombination protein RecR; Reviewed; Region: recR; PRK00076 517418003791 RecR protein; Region: RecR; pfam02132 517418003792 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 517418003793 putative active site [active] 517418003794 putative metal-binding site [ion binding]; other site 517418003795 tetramer interface [polypeptide binding]; other site 517418003796 phytoene desaturase; Region: phytoene_desat; TIGR02731 517418003797 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 517418003798 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 517418003799 Peptidase family U32; Region: Peptidase_U32; pfam01136 517418003800 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 517418003801 dimer interface [polypeptide binding]; other site 517418003802 [2Fe-2S] cluster binding site [ion binding]; other site 517418003803 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 517418003804 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 517418003805 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 517418003806 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 517418003807 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 517418003808 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 517418003809 HlyD family secretion protein; Region: HlyD_3; pfam13437 517418003810 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 517418003811 MarR family; Region: MarR_2; pfam12802 517418003812 MarR family; Region: MarR_2; cl17246 517418003813 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 517418003814 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 517418003815 Predicted ATPase [General function prediction only]; Region: COG3903 517418003816 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418003817 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418003818 binding surface 517418003819 TPR motif; other site 517418003820 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418003821 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418003822 Bacterial transcriptional activator domain; Region: BTAD; smart01043 517418003823 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 517418003824 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 517418003825 NAD(P) binding site [chemical binding]; other site 517418003826 active site 517418003827 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 517418003828 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 517418003829 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 517418003830 putative homodimer interface [polypeptide binding]; other site 517418003831 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 517418003832 heterodimer interface [polypeptide binding]; other site 517418003833 homodimer interface [polypeptide binding]; other site 517418003834 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 517418003835 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 517418003836 23S rRNA interface [nucleotide binding]; other site 517418003837 L7/L12 interface [polypeptide binding]; other site 517418003838 putative thiostrepton binding site; other site 517418003839 L25 interface [polypeptide binding]; other site 517418003840 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 517418003841 mRNA/rRNA interface [nucleotide binding]; other site 517418003842 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 517418003843 23S rRNA interface [nucleotide binding]; other site 517418003844 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 517418003845 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 517418003846 core dimer interface [polypeptide binding]; other site 517418003847 peripheral dimer interface [polypeptide binding]; other site 517418003848 L10 interface [polypeptide binding]; other site 517418003849 L11 interface [polypeptide binding]; other site 517418003850 putative EF-Tu interaction site [polypeptide binding]; other site 517418003851 putative EF-G interaction site [polypeptide binding]; other site 517418003852 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 517418003853 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 517418003854 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 517418003855 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 517418003856 RPB12 interaction site [polypeptide binding]; other site 517418003857 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 517418003858 RPB11 interaction site [polypeptide binding]; other site 517418003859 RPB12 interaction site [polypeptide binding]; other site 517418003860 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 517418003861 RPB12 interaction site [polypeptide binding]; other site 517418003862 RPB3 interaction site [polypeptide binding]; other site 517418003863 RPB1 interaction site [polypeptide binding]; other site 517418003864 RPB11 interaction site [polypeptide binding]; other site 517418003865 RPB10 interaction site [polypeptide binding]; other site 517418003866 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 517418003867 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 517418003868 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 517418003869 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 517418003870 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 517418003871 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 517418003872 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 517418003873 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 517418003874 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 517418003875 DNA binding site [nucleotide binding] 517418003876 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 517418003877 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 517418003878 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 517418003879 Zn binding site [ion binding]; other site 517418003880 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 517418003881 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 517418003882 spermidine synthase; Provisional; Region: PRK03612 517418003883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 517418003884 Predicted membrane protein [Function unknown]; Region: COG3766 517418003885 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 517418003886 Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; pfam02943 517418003887 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 517418003888 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 517418003889 Low molecular weight phosphatase family; Region: LMWPc; cd00115 517418003890 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 517418003891 active site 517418003892 Predicted permeases [General function prediction only]; Region: COG0701 517418003893 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 517418003894 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 517418003895 dimerization interface [polypeptide binding]; other site 517418003896 putative DNA binding site [nucleotide binding]; other site 517418003897 putative Zn2+ binding site [ion binding]; other site 517418003898 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 517418003899 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 517418003900 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 517418003901 DNA binding residues [nucleotide binding] 517418003902 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 517418003903 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 517418003904 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 517418003905 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 517418003906 active site 517418003907 aspartate aminotransferase; Provisional; Region: PRK05764 517418003908 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 517418003909 pyridoxal 5'-phosphate binding site [chemical binding]; other site 517418003910 homodimer interface [polypeptide binding]; other site 517418003911 catalytic residue [active] 517418003912 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 517418003913 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 517418003914 active site 517418003915 (T/H)XGH motif; other site 517418003916 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 517418003917 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 517418003918 S-adenosylmethionine binding site [chemical binding]; other site 517418003919 transketolase; Reviewed; Region: PRK05899 517418003920 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 517418003921 TPP-binding site [chemical binding]; other site 517418003922 dimer interface [polypeptide binding]; other site 517418003923 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 517418003924 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 517418003925 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 517418003926 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 517418003927 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 517418003928 ATP binding site [chemical binding]; other site 517418003929 active site 517418003930 substrate binding site [chemical binding]; other site 517418003931 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 517418003932 homodimer interface [polypeptide binding]; other site 517418003933 pyridoxal 5'-phosphate binding site [chemical binding]; other site 517418003934 catalytic residue [active] 517418003935 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 517418003936 nudix motif; other site 517418003937 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 517418003938 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 517418003939 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 517418003940 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 517418003941 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 517418003942 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 517418003943 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 517418003944 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 517418003945 14-3-3 domain; Region: 14-3-3; cl02098 517418003946 HlyD family secretion protein; Region: HlyD_3; pfam13437 517418003947 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 517418003948 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 517418003949 WHG domain; Region: WHG; pfam13305 517418003950 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 517418003951 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 517418003952 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 517418003953 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 517418003954 pyridoxal 5'-phosphate binding site [chemical binding]; other site 517418003955 catalytic residue [active] 517418003956 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 517418003957 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 517418003958 GTP binding site; other site 517418003959 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 517418003960 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 517418003961 Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654 517418003962 putative YPXnL-motif binding site; other site 517418003963 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 517418003964 MjaI restriction endonuclease; Region: RE_MjaI; pfam09568 517418003965 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 517418003966 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 517418003967 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 517418003968 active site 517418003969 (T/H)XGH motif; other site 517418003970 SdiA-regulated; Region: SdiA-regulated; cd09971 517418003971 putative active site [active] 517418003972 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 517418003973 thiamine monophosphate kinase; Provisional; Region: PRK05731 517418003974 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 517418003975 ATP binding site [chemical binding]; other site 517418003976 dimerization interface [polypeptide binding]; other site 517418003977 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 517418003978 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 517418003979 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 517418003980 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 517418003981 intersubunit interface [polypeptide binding]; other site 517418003982 active site 517418003983 catalytic residue [active] 517418003984 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 517418003985 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 517418003986 Walker A/P-loop; other site 517418003987 ATP binding site [chemical binding]; other site 517418003988 Q-loop/lid; other site 517418003989 ABC transporter signature motif; other site 517418003990 Walker B; other site 517418003991 D-loop; other site 517418003992 H-loop/switch region; other site 517418003993 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 517418003994 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 517418003995 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 517418003996 RNA binding site [nucleotide binding]; other site 517418003997 active site 517418003998 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 517418003999 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 517418004000 active site 517418004001 Riboflavin kinase; Region: Flavokinase; pfam01687 517418004002 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 517418004003 16S/18S rRNA binding site [nucleotide binding]; other site 517418004004 S13e-L30e interaction site [polypeptide binding]; other site 517418004005 25S rRNA binding site [nucleotide binding]; other site 517418004006 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 517418004007 excinuclease ABC subunit B; Provisional; Region: PRK05298 517418004008 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 517418004009 ATP binding site [chemical binding]; other site 517418004010 N-terminal domain conserved in slingshot (SSH) phosphatases; Region: SSH-N; cd11652 517418004011 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 517418004012 nucleotide binding region [chemical binding]; other site 517418004013 ATP-binding site [chemical binding]; other site 517418004014 Ultra-violet resistance protein B; Region: UvrB; pfam12344 517418004015 UvrB/uvrC motif; Region: UVR; pfam02151 517418004016 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 517418004017 Peptidase family M23; Region: Peptidase_M23; pfam01551 517418004018 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 517418004019 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 517418004020 Surface antigen; Region: Bac_surface_Ag; pfam01103 517418004021 Oxygen tolerance; Region: BatD; pfam13584 517418004022 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 517418004023 Radical SAM superfamily; Region: Radical_SAM; pfam04055 517418004024 FeS/SAM binding site; other site 517418004025 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 517418004026 LPP20 lipoprotein; Region: LPP20; pfam02169 517418004027 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 517418004028 Protein of unknown function (DUF3897); Region: DUF3897; pfam13036 517418004029 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 517418004030 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 517418004031 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 517418004032 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 517418004033 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 517418004034 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 517418004035 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 517418004036 active site 517418004037 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 517418004038 DinB superfamily; Region: DinB_2; pfam12867 517418004039 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 517418004040 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 517418004041 catalytic loop [active] 517418004042 iron binding site [ion binding]; other site 517418004043 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 517418004044 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 517418004045 catalytic loop [active] 517418004046 iron binding site [ion binding]; other site 517418004047 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 517418004048 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 517418004049 catalytic loop [active] 517418004050 iron binding site [ion binding]; other site 517418004051 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 517418004052 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 517418004053 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 517418004054 hexamer interface [polypeptide binding]; other site 517418004055 ligand binding site [chemical binding]; other site 517418004056 putative active site [active] 517418004057 NAD(P) binding site [chemical binding]; other site 517418004058 carotene isomerase; Region: carot_isom; TIGR02730 517418004059 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 517418004060 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 517418004061 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 517418004062 DNA binding residues [nucleotide binding] 517418004063 Putative zinc-finger; Region: zf-HC2; pfam13490 517418004064 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 517418004065 dimerization interface [polypeptide binding]; other site 517418004066 putative DNA binding site [nucleotide binding]; other site 517418004067 putative Zn2+ binding site [ion binding]; other site 517418004068 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 517418004069 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 517418004070 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 517418004071 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 517418004072 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 517418004073 putative dimer interface [polypeptide binding]; other site 517418004074 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 517418004075 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 517418004076 nucleotide binding site [chemical binding]; other site 517418004077 NEF interaction site [polypeptide binding]; other site 517418004078 SBD interface [polypeptide binding]; other site 517418004079 Photosystem P840 reaction centre protein PscD; Region: RC-P840_PscD; pfam10657 517418004080 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 517418004081 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 517418004082 NADP binding site [chemical binding]; other site 517418004083 active site 517418004084 putative substrate binding site [chemical binding]; other site 517418004085 geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023 517418004086 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 517418004087 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 517418004088 putative substrate-binding site; other site 517418004089 nickel binding site [ion binding]; other site 517418004090 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 517418004091 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 517418004092 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 517418004093 pyridoxal 5'-phosphate binding site [chemical binding]; other site 517418004094 homodimer interface [polypeptide binding]; other site 517418004095 catalytic residue [active] 517418004096 Cupin domain; Region: Cupin_2; pfam07883 517418004097 cobyric acid synthase; Provisional; Region: PRK00784 517418004098 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 517418004099 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 517418004100 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 517418004101 catalytic triad [active] 517418004102 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 517418004103 Predicted ATPase [General function prediction only]; Region: COG4637 517418004104 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 517418004105 Walker A/P-loop; other site 517418004106 ATP binding site [chemical binding]; other site 517418004107 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 517418004108 Walker B; other site 517418004109 D-loop; other site 517418004110 H-loop/switch region; other site 517418004111 16S rRNA methyltransferase B; Provisional; Region: PRK14904 517418004112 NusB family; Region: NusB; pfam01029 517418004113 putative RNA binding site [nucleotide binding]; other site 517418004114 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 517418004115 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 517418004116 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 517418004117 homodimer interface [polypeptide binding]; other site 517418004118 substrate-cofactor binding pocket; other site 517418004119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 517418004120 catalytic residue [active] 517418004121 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 517418004122 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 517418004123 Phytase; Region: Phytase; cl17685 517418004124 Cna protein B-type domain; Region: Cna_B_2; pfam13715 517418004125 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 517418004126 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 517418004127 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 517418004128 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 517418004129 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 517418004130 S-adenosylmethionine binding site [chemical binding]; other site 517418004131 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 517418004132 magnesium chelatase subunit H; Provisional; Region: PRK12493 517418004133 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 517418004134 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 517418004135 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 517418004136 magnesium chelatase, H subunit; Region: BchH; TIGR02025 517418004137 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 517418004138 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 517418004139 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 517418004140 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 517418004141 Cna protein B-type domain; Region: Cna_B_2; pfam13715 517418004142 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 517418004143 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 517418004144 N-terminal plug; other site 517418004145 ligand-binding site [chemical binding]; other site 517418004146 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 517418004147 B12 binding site [chemical binding]; other site 517418004148 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 517418004149 Exonuclease III [DNA replication, recombination, and repair]; Region: XthA; COG0708 517418004150 putative catalytic site [active] 517418004151 putative metal binding site [ion binding]; other site 517418004152 putative phosphate binding site [ion binding]; other site 517418004153 FOG: WD40 repeat [General function prediction only]; Region: COG2319 517418004154 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 517418004155 structural tetrad; other site 517418004156 FOG: WD40 repeat [General function prediction only]; Region: COG2319 517418004157 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 517418004158 structural tetrad; other site 517418004159 AAA domain; Region: AAA_28; pfam13521 517418004160 Predicted ATPase [General function prediction only]; Region: COG3911 517418004161 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 517418004162 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 517418004163 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 517418004164 Ion channel; Region: Ion_trans_2; pfam07885 517418004165 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 517418004166 TrkA-N domain; Region: TrkA_N; pfam02254 517418004167 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 517418004168 ligand binding site [chemical binding]; other site 517418004169 flexible hinge region; other site 517418004170 dihydroorotase; Validated; Region: pyrC; PRK09357 517418004171 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 517418004172 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 517418004173 active site 517418004174 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 517418004175 metal binding site 2 [ion binding]; metal-binding site 517418004176 putative DNA binding helix; other site 517418004177 metal binding site 1 [ion binding]; metal-binding site 517418004178 dimer interface [polypeptide binding]; other site 517418004179 structural Zn2+ binding site [ion binding]; other site 517418004180 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 517418004181 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 517418004182 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 517418004183 dimerization interface [polypeptide binding]; other site 517418004184 active site 517418004185 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 517418004186 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 517418004187 active site 517418004188 NTP binding site [chemical binding]; other site 517418004189 metal binding triad [ion binding]; metal-binding site 517418004190 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 517418004191 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 517418004192 Zn2+ binding site [ion binding]; other site 517418004193 Mg2+ binding site [ion binding]; other site 517418004194 ribonuclease E; Reviewed; Region: rne; PRK10811 517418004195 Predicted membrane protein [Function unknown]; Region: COG2510 517418004196 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 517418004197 putative catalytic site [active] 517418004198 putative metal binding site [ion binding]; other site 517418004199 putative phosphate binding site [ion binding]; other site 517418004200 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 517418004201 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 517418004202 homodimer interface [polypeptide binding]; other site 517418004203 active site pocket [active] 517418004204 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 517418004205 TIR domain; Region: TIR_2; pfam13676 517418004206 NB-ARC domain; Region: NB-ARC; pfam00931 517418004207 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418004208 binding surface 517418004209 TPR motif; other site 517418004210 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418004211 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418004212 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418004213 TPR motif; other site 517418004214 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418004215 binding surface 517418004216 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 517418004217 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 517418004218 ABC-2 type transporter; Region: ABC2_membrane; cl17235 517418004219 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 517418004220 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 517418004221 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 517418004222 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 517418004223 Walker A/P-loop; other site 517418004224 ATP binding site [chemical binding]; other site 517418004225 Q-loop/lid; other site 517418004226 ABC transporter signature motif; other site 517418004227 Walker B; other site 517418004228 D-loop; other site 517418004229 H-loop/switch region; other site 517418004230 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 517418004231 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 517418004232 Walker A/P-loop; other site 517418004233 ATP binding site [chemical binding]; other site 517418004234 Q-loop/lid; other site 517418004235 ABC transporter signature motif; other site 517418004236 Walker B; other site 517418004237 D-loop; other site 517418004238 H-loop/switch region; other site 517418004239 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 517418004240 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 517418004241 HlyD family secretion protein; Region: HlyD_3; pfam13437 517418004242 Outer membrane efflux protein; Region: OEP; pfam02321 517418004243 Outer membrane efflux protein; Region: OEP; pfam02321 517418004244 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 517418004245 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 517418004246 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 517418004247 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 517418004248 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 517418004249 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 517418004250 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 517418004251 RNA/DNA hybrid binding site [nucleotide binding]; other site 517418004252 active site 517418004253 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 517418004254 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 517418004255 catalytic triad [active] 517418004256 GTP-binding protein Der; Reviewed; Region: PRK00093 517418004257 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 517418004258 G1 box; other site 517418004259 GTP/Mg2+ binding site [chemical binding]; other site 517418004260 Switch I region; other site 517418004261 G2 box; other site 517418004262 Switch II region; other site 517418004263 G3 box; other site 517418004264 G4 box; other site 517418004265 G5 box; other site 517418004266 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 517418004267 G1 box; other site 517418004268 GTP/Mg2+ binding site [chemical binding]; other site 517418004269 Switch I region; other site 517418004270 G2 box; other site 517418004271 G3 box; other site 517418004272 Switch II region; other site 517418004273 G4 box; other site 517418004274 G5 box; other site 517418004275 antiporter inner membrane protein; Provisional; Region: PRK11670 517418004276 Domain of unknown function DUF59; Region: DUF59; pfam01883 517418004277 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 517418004278 Walker A motif; other site 517418004279 NifU-like domain; Region: NifU; pfam01106 517418004280 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 517418004281 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 517418004282 dimer interface [polypeptide binding]; other site 517418004283 conserved gate region; other site 517418004284 putative PBP binding loops; other site 517418004285 ABC-ATPase subunit interface; other site 517418004286 membrane ATPase/protein kinase; Provisional; Region: PRK09435 517418004287 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 517418004288 GTP/Mg2+ binding site [chemical binding]; other site 517418004289 G5 box; other site 517418004290 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 517418004291 Walker A; other site 517418004292 G1 box; other site 517418004293 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 517418004294 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 517418004295 HSP70 interaction site [polypeptide binding]; other site 517418004296 peptide chain release factor 2; Validated; Region: prfB; PRK00578 517418004297 PCRF domain; Region: PCRF; pfam03462 517418004298 RF-1 domain; Region: RF-1; pfam00472 517418004299 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 517418004300 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 517418004301 minor groove reading motif; other site 517418004302 helix-hairpin-helix signature motif; other site 517418004303 substrate binding pocket [chemical binding]; other site 517418004304 active site 517418004305 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 517418004306 Uncharacterized conserved protein [Function unknown]; Region: COG2135 517418004307 Homo sapiens Nbla03831 and related proteins, metallophosphatase domain; Region: MPP_Nbla03831; cd07396 517418004308 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 517418004309 active site 517418004310 metal binding site [ion binding]; metal-binding site 517418004311 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 517418004312 dihydropteroate synthase; Region: DHPS; TIGR01496 517418004313 substrate binding pocket [chemical binding]; other site 517418004314 dimer interface [polypeptide binding]; other site 517418004315 inhibitor binding site; inhibition site 517418004316 Uncharacterized conserved protein [Function unknown]; Region: COG1624 517418004317 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 517418004318 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 517418004319 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 517418004320 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 517418004321 ABC transporter; Region: ABC_tran_2; pfam12848 517418004322 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 517418004323 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 517418004324 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 517418004325 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 517418004326 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 517418004327 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 517418004328 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 517418004329 aspartate kinase III; Validated; Region: PRK09084 517418004330 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 517418004331 putative catalytic residues [active] 517418004332 nucleotide binding site [chemical binding]; other site 517418004333 aspartate binding site [chemical binding]; other site 517418004334 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912 517418004335 dimer interface [polypeptide binding]; other site 517418004336 allosteric regulatory binding pocket; other site 517418004337 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 517418004338 Response regulator receiver domain; Region: Response_reg; pfam00072 517418004339 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418004340 active site 517418004341 phosphorylation site [posttranslational modification] 517418004342 intermolecular recognition site; other site 517418004343 dimerization interface [polypeptide binding]; other site 517418004344 PglZ domain; Region: PglZ; pfam08665 517418004345 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 517418004346 KWG Leptospira; Region: KWG; pfam07656 517418004347 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 517418004348 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 517418004349 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 517418004350 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 517418004351 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 517418004352 trimer interface [polypeptide binding]; other site 517418004353 active site 517418004354 substrate binding site [chemical binding]; other site 517418004355 CoA binding site [chemical binding]; other site 517418004356 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 517418004357 MoaE interaction surface [polypeptide binding]; other site 517418004358 MoeB interaction surface [polypeptide binding]; other site 517418004359 thiocarboxylated glycine; other site 517418004360 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 517418004361 MoaE homodimer interface [polypeptide binding]; other site 517418004362 MoaD interaction [polypeptide binding]; other site 517418004363 active site residues [active] 517418004364 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 517418004365 putative active site pocket [active] 517418004366 dimerization interface [polypeptide binding]; other site 517418004367 putative catalytic residue [active] 517418004368 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 517418004369 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 517418004370 hinge; other site 517418004371 active site 517418004372 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 517418004373 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 517418004374 active site clefts [active] 517418004375 zinc binding site [ion binding]; other site 517418004376 dimer interface [polypeptide binding]; other site 517418004377 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 517418004378 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 517418004379 putative catalytic residues [active] 517418004380 putative nucleotide binding site [chemical binding]; other site 517418004381 putative aspartate binding site [chemical binding]; other site 517418004382 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 517418004383 dimer interface [polypeptide binding]; other site 517418004384 putative threonine allosteric regulatory site; other site 517418004385 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 517418004386 putative threonine allosteric regulatory site; other site 517418004387 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 517418004388 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 517418004389 YtxH-like protein; Region: YtxH; pfam12732 517418004390 Acylphosphatase; Region: Acylphosphatase; pfam00708 517418004391 FtsH Extracellular; Region: FtsH_ext; pfam06480 517418004392 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 517418004393 hypothetical protein; Provisional; Region: PHA03029 517418004394 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 517418004395 Walker B motif; other site 517418004396 arginine finger; other site 517418004397 Peptidase family M41; Region: Peptidase_M41; pfam01434 517418004398 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 517418004399 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 517418004400 active site 517418004401 ribulose/triose binding site [chemical binding]; other site 517418004402 phosphate binding site [ion binding]; other site 517418004403 substrate (anthranilate) binding pocket [chemical binding]; other site 517418004404 product (indole) binding pocket [chemical binding]; other site 517418004405 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418004406 binding surface 517418004407 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418004408 TPR motif; other site 517418004409 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418004410 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418004411 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418004412 binding surface 517418004413 TPR motif; other site 517418004414 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418004415 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418004416 binding surface 517418004417 TPR motif; other site 517418004418 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418004419 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418004420 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418004421 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418004422 binding surface 517418004423 TPR motif; other site 517418004424 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418004425 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418004426 SnoaL-like domain; Region: SnoaL_2; pfam12680 517418004427 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 517418004428 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 517418004429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 517418004430 dimer interface [polypeptide binding]; other site 517418004431 conserved gate region; other site 517418004432 putative PBP binding loops; other site 517418004433 ABC-ATPase subunit interface; other site 517418004434 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 517418004435 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 517418004436 P-loop; other site 517418004437 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 517418004438 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 517418004439 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 517418004440 light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842 517418004441 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 517418004442 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 517418004443 Peptidase family M23; Region: Peptidase_M23; pfam01551 517418004444 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 517418004445 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 517418004446 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 517418004447 F0F1 ATP synthase subunit A; Provisional; Region: PRK13419 517418004448 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 517418004449 F0F1 ATP synthase subunit B; Provisional; Region: PRK14472 517418004450 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 517418004451 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 517418004452 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 517418004453 hypothetical protein; Reviewed; Region: PRK12497 517418004454 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 517418004455 RNA/DNA hybrid binding site [nucleotide binding]; other site 517418004456 active site 517418004457 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 517418004458 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 517418004459 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202 517418004460 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 517418004461 putative NAD(P) binding site [chemical binding]; other site 517418004462 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 517418004463 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 517418004464 Walker A/P-loop; other site 517418004465 ATP binding site [chemical binding]; other site 517418004466 Q-loop/lid; other site 517418004467 ABC transporter signature motif; other site 517418004468 Walker B; other site 517418004469 D-loop; other site 517418004470 H-loop/switch region; other site 517418004471 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 517418004472 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418004473 binding surface 517418004474 TPR motif; other site 517418004475 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418004476 binding surface 517418004477 TPR motif; other site 517418004478 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418004479 binding surface 517418004480 TPR motif; other site 517418004481 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 517418004482 TPR motif; other site 517418004483 binding surface 517418004484 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 517418004485 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 517418004486 ligand binding site [chemical binding]; other site 517418004487 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 517418004488 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 517418004489 active site 517418004490 ADP/pyrophosphate binding site [chemical binding]; other site 517418004491 dimerization interface [polypeptide binding]; other site 517418004492 allosteric effector site; other site 517418004493 fructose-1,6-bisphosphate binding site; other site 517418004494 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 517418004495 active site 517418004496 substrate-binding site [chemical binding]; other site 517418004497 metal-binding site [ion binding] 517418004498 GTP binding site [chemical binding]; other site 517418004499 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 517418004500 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418004501 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418004502 binding surface 517418004503 TPR motif; other site 517418004504 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418004505 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418004506 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418004507 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418004508 binding surface 517418004509 TPR motif; other site 517418004510 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418004511 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418004512 binding surface 517418004513 TPR motif; other site 517418004514 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418004515 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 517418004516 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 517418004517 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 517418004518 DNA binding residues [nucleotide binding] 517418004519 DPS-like protein, ferritin-like diiron-binding domain; Region: DPSL; cd01052 517418004520 Ferritin-like domain; Region: Ferritin; pfam00210 517418004521 diiron binding motif [ion binding]; other site 517418004522 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 517418004523 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 517418004524 FAD binding pocket [chemical binding]; other site 517418004525 FAD binding motif [chemical binding]; other site 517418004526 phosphate binding motif [ion binding]; other site 517418004527 beta-alpha-beta structure motif; other site 517418004528 NAD binding pocket [chemical binding]; other site 517418004529 Iron coordination center [ion binding]; other site 517418004530 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 517418004531 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 517418004532 catalytic residues [active] 517418004533 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 517418004534 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 517418004535 putative active site [active] 517418004536 oxyanion strand; other site 517418004537 catalytic triad [active] 517418004538 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 517418004539 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 517418004540 catalytic residues [active] 517418004541 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 517418004542 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 517418004543 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 517418004544 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 517418004545 ATP-grasp domain; Region: ATP-grasp_4; cl17255 517418004546 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 517418004547 IMP binding site; other site 517418004548 dimer interface [polypeptide binding]; other site 517418004549 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 517418004550 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 517418004551 Walker A/P-loop; other site 517418004552 ATP binding site [chemical binding]; other site 517418004553 Q-loop/lid; other site 517418004554 ABC transporter signature motif; other site 517418004555 Walker B; other site 517418004556 D-loop; other site 517418004557 H-loop/switch region; other site 517418004558 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 517418004559 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 517418004560 FtsX-like permease family; Region: FtsX; pfam02687 517418004561 Motility related/secretion protein; Region: SprA_N; pfam14349 517418004562 Motility related/secretion protein; Region: SprA_N; pfam14349 517418004563 Motility related/secretion protein; Region: SprA_N; pfam14349 517418004564 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14671 517418004565 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 517418004566 GIY-YIG motif/motif A; other site 517418004567 active site 517418004568 catalytic site [active] 517418004569 putative DNA binding site [nucleotide binding]; other site 517418004570 metal binding site [ion binding]; metal-binding site 517418004571 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 517418004572 Predicted amidohydrolase [General function prediction only]; Region: COG0388 517418004573 Pyrococcus horikoshii Ph0642 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Ph0642_like; cd07577 517418004574 putative active site [active] 517418004575 catalytic triad [active] 517418004576 dimer interface [polypeptide binding]; other site 517418004577 putative tetramer interface [polypeptide binding]; other site 517418004578 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 517418004579 elongation factor G; Reviewed; Region: PRK12740 517418004580 G1 box; other site 517418004581 putative GEF interaction site [polypeptide binding]; other site 517418004582 GTP/Mg2+ binding site [chemical binding]; other site 517418004583 Switch I region; other site 517418004584 G2 box; other site 517418004585 G3 box; other site 517418004586 Switch II region; other site 517418004587 G4 box; other site 517418004588 G5 box; other site 517418004589 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 517418004590 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 517418004591 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 517418004592 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 517418004593 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 517418004594 Ligand binding site; other site 517418004595 Putative Catalytic site; other site 517418004596 DXD motif; other site 517418004597 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 517418004598 Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224 517418004599 Helix-turn-helix domain; Region: HTH_17; pfam12728 517418004600 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 517418004601 B12 binding domain; Region: B12-binding_2; pfam02607 517418004602 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 517418004603 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 517418004604 active site 517418004605 intersubunit interactions; other site 517418004606 catalytic residue [active] 517418004607 deoxyhypusine synthase-like protein; Provisional; Region: PRK02492 517418004608 deoxyhypusine synthase; Region: dhys; TIGR00321 517418004609 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 517418004610 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 517418004611 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 517418004612 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 517418004613 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 517418004614 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 517418004615 TM-ABC transporter signature motif; other site 517418004616 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 517418004617 Phage Tail Collar Domain; Region: Collar; pfam07484 517418004618 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 517418004619 Interdomain contacts; other site 517418004620 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 517418004621 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 517418004622 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 517418004623 Ligand Binding Site [chemical binding]; other site 517418004624 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 517418004625 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 517418004626 nucleophile elbow; other site 517418004627 Surface antigen; Region: Bac_surface_Ag; pfam01103 517418004628 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 517418004629 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 517418004630 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 517418004631 TPR repeat; Region: TPR_11; pfam13414 517418004632 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418004633 TPR motif; other site 517418004634 binding surface 517418004635 Tetratricopeptide repeat; Region: TPR_16; pfam13432 517418004636 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418004637 binding surface 517418004638 TPR motif; other site 517418004639 Tetratricopeptide repeat; Region: TPR_16; pfam13432 517418004640 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418004641 binding surface 517418004642 TPR repeat; Region: TPR_11; pfam13414 517418004643 TPR motif; other site 517418004644 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418004645 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418004646 binding surface 517418004647 TPR repeat; Region: TPR_11; pfam13414 517418004648 TPR motif; other site 517418004649 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418004650 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418004651 TPR motif; other site 517418004652 Gram-negative bacterial tonB protein; Region: TonB; cl10048 517418004653 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 517418004654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 517418004655 dimer interface [polypeptide binding]; other site 517418004656 conserved gate region; other site 517418004657 putative PBP binding loops; other site 517418004658 ABC-ATPase subunit interface; other site 517418004659 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 517418004660 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 517418004661 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 517418004662 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 517418004663 HIGH motif; other site 517418004664 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 517418004665 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 517418004666 active site 517418004667 KMSKS motif; other site 517418004668 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 517418004669 tRNA binding surface [nucleotide binding]; other site 517418004670 YcfA-like protein; Region: YcfA; pfam07927 517418004671 Methyltransferase domain; Region: Methyltransf_23; pfam13489 517418004672 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 517418004673 S-adenosylmethionine binding site [chemical binding]; other site 517418004674 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 517418004675 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 517418004676 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 517418004677 inhibitor-cofactor binding pocket; inhibition site 517418004678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 517418004679 catalytic residue [active] 517418004680 Uncharacterized conserved protein [Function unknown]; Region: COG0062 517418004681 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 517418004682 putative substrate binding site [chemical binding]; other site 517418004683 putative ATP binding site [chemical binding]; other site 517418004684 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 517418004685 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 517418004686 active site 517418004687 multimer interface [polypeptide binding]; other site 517418004688 gamma-glutamyl kinase; Provisional; Region: PRK05429 517418004689 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 517418004690 nucleotide binding site [chemical binding]; other site 517418004691 homotetrameric interface [polypeptide binding]; other site 517418004692 putative phosphate binding site [ion binding]; other site 517418004693 putative allosteric binding site; other site 517418004694 PUA domain; Region: PUA; pfam01472 517418004695 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 517418004696 aspartate racemase; Region: asp_race; TIGR00035 517418004697 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 517418004698 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 517418004699 Transposase [DNA replication, recombination, and repair]; Region: COG5433 517418004700 Transposase [DNA replication, recombination, and repair]; Region: COG5433 517418004701 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 517418004702 Protein export membrane protein; Region: SecD_SecF; cl14618 517418004703 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 517418004704 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 517418004705 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 517418004706 putative catalytic cysteine [active] 517418004707 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 517418004708 Zn2+ binding site [ion binding]; other site 517418004709 Mg2+ binding site [ion binding]; other site 517418004710 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 517418004711 Zn2+ binding site [ion binding]; other site 517418004712 Mg2+ binding site [ion binding]; other site 517418004713 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 517418004714 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 517418004715 nudix motif; other site 517418004716 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 517418004717 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 517418004718 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 517418004719 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 517418004720 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 517418004721 active site 517418004722 Mu-like prophage protein [General function prediction only]; Region: COG3941 517418004723 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 517418004724 Double zinc ribbon; Region: DZR; pfam12773 517418004725 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 517418004726 TPR repeat; Region: TPR_11; pfam13414 517418004727 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418004728 binding surface 517418004729 TPR repeat; Region: TPR_11; pfam13414 517418004730 TPR motif; other site 517418004731 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 517418004732 IHF dimer interface [polypeptide binding]; other site 517418004733 IHF - DNA interface [nucleotide binding]; other site 517418004734 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 517418004735 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 517418004736 Walker B motif; other site 517418004737 arginine finger; other site 517418004738 Peptidase family M41; Region: Peptidase_M41; pfam01434 517418004739 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 517418004740 active site 517418004741 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 517418004742 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 517418004743 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 517418004744 Walker A/P-loop; other site 517418004745 ATP binding site [chemical binding]; other site 517418004746 Q-loop/lid; other site 517418004747 ABC transporter signature motif; other site 517418004748 Walker B; other site 517418004749 D-loop; other site 517418004750 H-loop/switch region; other site 517418004751 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 517418004752 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 517418004753 Surface antigen; Region: Bac_surface_Ag; pfam01103 517418004754 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 517418004755 spermidine synthase; Provisional; Region: PRK00811 517418004756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 517418004757 S-adenosylmethionine binding site [chemical binding]; other site 517418004758 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 517418004759 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 517418004760 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 517418004761 catalytic triad [active] 517418004762 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 517418004763 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 517418004764 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 517418004765 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 517418004766 Walker A/P-loop; other site 517418004767 ATP binding site [chemical binding]; other site 517418004768 Q-loop/lid; other site 517418004769 ABC transporter signature motif; other site 517418004770 Walker B; other site 517418004771 D-loop; other site 517418004772 H-loop/switch region; other site 517418004773 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 517418004774 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 517418004775 mce related protein; Region: MCE; pfam02470 517418004776 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 517418004777 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 517418004778 active site 517418004779 Int/Topo IB signature motif; other site 517418004780 Motility related/secretion protein; Region: SprA_N; pfam14349 517418004781 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 517418004782 dimerization interface [polypeptide binding]; other site 517418004783 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 517418004784 cyclase homology domain; Region: CHD; cd07302 517418004785 nucleotidyl binding site; other site 517418004786 metal binding site [ion binding]; metal-binding site 517418004787 dimer interface [polypeptide binding]; other site 517418004788 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 517418004789 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 517418004790 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 517418004791 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 517418004792 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418004793 putative active site [active] 517418004794 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 517418004795 heme pocket [chemical binding]; other site 517418004796 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 517418004797 dimer interface [polypeptide binding]; other site 517418004798 phosphorylation site [posttranslational modification] 517418004799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418004800 ATP binding site [chemical binding]; other site 517418004801 Mg2+ binding site [ion binding]; other site 517418004802 G-X-G motif; other site 517418004803 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 517418004804 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 517418004805 oligomerisation interface [polypeptide binding]; other site 517418004806 mobile loop; other site 517418004807 roof hairpin; other site 517418004808 quinolinate synthetase; Provisional; Region: PRK09375 517418004809 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 517418004810 putative active site pocket [active] 517418004811 dimerization interface [polypeptide binding]; other site 517418004812 putative catalytic residue [active] 517418004813 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 517418004814 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 517418004815 Domain of unknown function (DUF368); Region: DUF368; pfam04018 517418004816 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 517418004817 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 517418004818 TPP-binding site [chemical binding]; other site 517418004819 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 517418004820 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 517418004821 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 517418004822 dimer interface [polypeptide binding]; other site 517418004823 PYR/PP interface [polypeptide binding]; other site 517418004824 TPP binding site [chemical binding]; other site 517418004825 substrate binding site [chemical binding]; other site 517418004826 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 517418004827 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 517418004828 P loop; other site 517418004829 Nucleotide binding site [chemical binding]; other site 517418004830 DTAP/Switch II; other site 517418004831 Switch I; other site 517418004832 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 517418004833 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 517418004834 Ligand Binding Site [chemical binding]; other site 517418004835 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 517418004836 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 517418004837 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 517418004838 active site 517418004839 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 517418004840 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 517418004841 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 517418004842 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 517418004843 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 517418004844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 517418004845 S-adenosylmethionine binding site [chemical binding]; other site 517418004846 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 517418004847 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 517418004848 acetylornithine aminotransferase; Provisional; Region: PRK02627 517418004849 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 517418004850 inhibitor-cofactor binding pocket; inhibition site 517418004851 pyridoxal 5'-phosphate binding site [chemical binding]; other site 517418004852 catalytic residue [active] 517418004853 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 517418004854 Mechanosensitive ion channel; Region: MS_channel; pfam00924 517418004855 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 517418004856 A new structural DNA glycosylase; Region: AlkD_like; cd06561 517418004857 active site 517418004858 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 517418004859 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 517418004860 dimer interface [polypeptide binding]; other site 517418004861 pyridoxal 5'-phosphate binding site [chemical binding]; other site 517418004862 catalytic residue [active] 517418004863 Family description; Region: VCBS; pfam13517 517418004864 Family description; Region: VCBS; pfam13517 517418004865 Family description; Region: VCBS; pfam13517 517418004866 Family description; Region: VCBS; pfam13517 517418004867 Family description; Region: VCBS; pfam13517 517418004868 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 517418004869 active site 517418004870 catalytic residues [active] 517418004871 metal binding site [ion binding]; metal-binding site 517418004872 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 517418004873 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 517418004874 putative active site [active] 517418004875 substrate binding site [chemical binding]; other site 517418004876 putative cosubstrate binding site; other site 517418004877 catalytic site [active] 517418004878 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 517418004879 substrate binding site [chemical binding]; other site 517418004880 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 517418004881 Mechanosensitive ion channel; Region: MS_channel; pfam00924 517418004882 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 517418004883 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 517418004884 catalytic residues [active] 517418004885 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 517418004886 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 517418004887 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 517418004888 putative tRNA-binding site [nucleotide binding]; other site 517418004889 B3/4 domain; Region: B3_4; pfam03483 517418004890 tRNA synthetase B5 domain; Region: B5; smart00874 517418004891 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 517418004892 dimer interface [polypeptide binding]; other site 517418004893 motif 1; other site 517418004894 motif 3; other site 517418004895 motif 2; other site 517418004896 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 517418004897 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 517418004898 Cell division protein ZapA; Region: ZapA; pfam05164 517418004899 phosphodiesterase; Provisional; Region: PRK12704 517418004900 KH domain; Region: KH_1; pfam00013 517418004901 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 517418004902 Zn2+ binding site [ion binding]; other site 517418004903 Mg2+ binding site [ion binding]; other site 517418004904 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 517418004905 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 517418004906 GDP-binding site [chemical binding]; other site 517418004907 ACT binding site; other site 517418004908 IMP binding site; other site 517418004909 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 517418004910 G1 box; other site 517418004911 GTP/Mg2+ binding site [chemical binding]; other site 517418004912 Switch I region; other site 517418004913 G2 box; other site 517418004914 G3 box; other site 517418004915 Switch II region; other site 517418004916 G4 box; other site 517418004917 G5 box; other site 517418004918 Domain of unknown function (DUF309); Region: DUF309; pfam03745 517418004919 Septum formation initiator; Region: DivIC; pfam04977 517418004920 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 517418004921 GcpE protein; Region: GcpE; pfam04551 517418004922 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 517418004923 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 517418004924 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 517418004925 putative acyl-acceptor binding pocket; other site 517418004926 YceI-like domain; Region: YceI; smart00867 517418004927 adenylate kinase; Reviewed; Region: adk; PRK00279 517418004928 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 517418004929 AMP-binding site [chemical binding]; other site 517418004930 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 517418004931 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 517418004932 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 517418004933 FeS/SAM binding site; other site 517418004934 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 517418004935 active site 517418004936 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 517418004937 HAMP domain; Region: HAMP; pfam00672 517418004938 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 517418004939 dimer interface [polypeptide binding]; other site 517418004940 phosphorylation site [posttranslational modification] 517418004941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418004942 ATP binding site [chemical binding]; other site 517418004943 Mg2+ binding site [ion binding]; other site 517418004944 G-X-G motif; other site 517418004945 FecR protein; Region: FecR; pfam04773 517418004946 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 517418004947 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 517418004948 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 517418004949 FOG: PKD repeat [General function prediction only]; Region: COG3291 517418004950 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 517418004951 FOG: PKD repeat [General function prediction only]; Region: COG3291 517418004952 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 517418004953 16S rRNA methyltransferase B; Provisional; Region: PRK14901 517418004954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 517418004955 S-adenosylmethionine binding site [chemical binding]; other site 517418004956 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 517418004957 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 517418004958 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 517418004959 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 517418004960 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 517418004961 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 517418004962 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 517418004963 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 517418004964 Walker A/P-loop; other site 517418004965 ATP binding site [chemical binding]; other site 517418004966 Q-loop/lid; other site 517418004967 ABC transporter signature motif; other site 517418004968 Walker B; other site 517418004969 D-loop; other site 517418004970 H-loop/switch region; other site 517418004971 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 517418004972 Hexamer/Pentamer interface [polypeptide binding]; other site 517418004973 central pore; other site 517418004974 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 517418004975 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 517418004976 GTPase RsgA; Reviewed; Region: PRK00098 517418004977 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 517418004978 RNA binding site [nucleotide binding]; other site 517418004979 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 517418004980 GTPase/Zn-binding domain interface [polypeptide binding]; other site 517418004981 GTP/Mg2+ binding site [chemical binding]; other site 517418004982 G4 box; other site 517418004983 G5 box; other site 517418004984 G1 box; other site 517418004985 Switch I region; other site 517418004986 G2 box; other site 517418004987 G3 box; other site 517418004988 Switch II region; other site 517418004989 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 517418004990 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 517418004991 generic binding surface II; other site 517418004992 ssDNA binding site; other site 517418004993 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 517418004994 ATP binding site [chemical binding]; other site 517418004995 putative Mg++ binding site [ion binding]; other site 517418004996 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 517418004997 nucleotide binding region [chemical binding]; other site 517418004998 ATP-binding site [chemical binding]; other site 517418004999 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 517418005000 ribosome recycling factor; Reviewed; Region: frr; PRK00083 517418005001 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 517418005002 hinge region; other site 517418005003 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418005004 PAS domain; Region: PAS_9; pfam13426 517418005005 putative active site [active] 517418005006 PAS domain; Region: PAS_9; pfam13426 517418005007 PAS domain S-box; Region: sensory_box; TIGR00229 517418005008 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418005009 putative active site [active] 517418005010 heme pocket [chemical binding]; other site 517418005011 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418005012 PAS domain; Region: PAS_9; pfam13426 517418005013 putative active site [active] 517418005014 heme pocket [chemical binding]; other site 517418005015 GAF domain; Region: GAF_2; pfam13185 517418005016 histidine kinase; Provisional; Region: PRK13557 517418005017 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418005018 putative active site [active] 517418005019 heme pocket [chemical binding]; other site 517418005020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418005021 ATP binding site [chemical binding]; other site 517418005022 Mg2+ binding site [ion binding]; other site 517418005023 G-X-G motif; other site 517418005024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418005025 active site 517418005026 phosphorylation site [posttranslational modification] 517418005027 intermolecular recognition site; other site 517418005028 dimerization interface [polypeptide binding]; other site 517418005029 adenylosuccinate lyase; Provisional; Region: PRK07492 517418005030 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 517418005031 tetramer interface [polypeptide binding]; other site 517418005032 active site 517418005033 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 517418005034 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 517418005035 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 517418005036 purine monophosphate binding site [chemical binding]; other site 517418005037 dimer interface [polypeptide binding]; other site 517418005038 putative catalytic residues [active] 517418005039 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 517418005040 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 517418005041 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 517418005042 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 517418005043 active site 517418005044 substrate binding site [chemical binding]; other site 517418005045 cosubstrate binding site; other site 517418005046 catalytic site [active] 517418005047 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 517418005048 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 517418005049 FeS/SAM binding site; other site 517418005050 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 517418005051 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 517418005052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418005053 ATP binding site [chemical binding]; other site 517418005054 Mg2+ binding site [ion binding]; other site 517418005055 G-X-G motif; other site 517418005056 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 517418005057 anchoring element; other site 517418005058 dimer interface [polypeptide binding]; other site 517418005059 ATP binding site [chemical binding]; other site 517418005060 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 517418005061 active site 517418005062 putative metal-binding site [ion binding]; other site 517418005063 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 517418005064 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 517418005065 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 517418005066 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 517418005067 active site 517418005068 Dodecin; Region: Dodecin; pfam07311 517418005069 Ion channel; Region: Ion_trans_2; pfam07885 517418005070 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 517418005071 TrkA-N domain; Region: TrkA_N; pfam02254 517418005072 TrkA-C domain; Region: TrkA_C; pfam02080 517418005073 SnoaL-like domain; Region: SnoaL_3; pfam13474 517418005074 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 517418005075 Isochorismatase family; Region: Isochorismatase; pfam00857 517418005076 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 517418005077 catalytic triad [active] 517418005078 dimer interface [polypeptide binding]; other site 517418005079 conserved cis-peptide bond; other site 517418005080 acyl carrier protein; Provisional; Region: acpP; PRK00982 517418005081 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 517418005082 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 517418005083 dimer interface [polypeptide binding]; other site 517418005084 active site 517418005085 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 517418005086 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 517418005087 dimerization interface [polypeptide binding]; other site 517418005088 active site 517418005089 metal binding site [ion binding]; metal-binding site 517418005090 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 517418005091 dsRNA binding site [nucleotide binding]; other site 517418005092 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 517418005093 tetramer interface [polypeptide binding]; other site 517418005094 pyridoxal 5'-phosphate binding site [chemical binding]; other site 517418005095 catalytic residue [active] 517418005096 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 517418005097 Domain of unknown function DUF21; Region: DUF21; pfam01595 517418005098 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 517418005099 Transporter associated domain; Region: CorC_HlyC; smart01091 517418005100 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 517418005101 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 517418005102 Walker A/P-loop; other site 517418005103 ATP binding site [chemical binding]; other site 517418005104 Q-loop/lid; other site 517418005105 ABC transporter signature motif; other site 517418005106 Walker B; other site 517418005107 D-loop; other site 517418005108 H-loop/switch region; other site 517418005109 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 517418005110 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 517418005111 tandem repeat interface [polypeptide binding]; other site 517418005112 oligomer interface [polypeptide binding]; other site 517418005113 active site residues [active] 517418005114 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 517418005115 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 517418005116 tandem repeat interface [polypeptide binding]; other site 517418005117 oligomer interface [polypeptide binding]; other site 517418005118 active site residues [active] 517418005119 Helix-turn-helix domain; Region: HTH_25; pfam13413 517418005120 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 517418005121 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 517418005122 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 517418005123 active site 517418005124 HIGH motif; other site 517418005125 nucleotide binding site [chemical binding]; other site 517418005126 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 517418005127 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 517418005128 active site 517418005129 KMSKS motif; other site 517418005130 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 517418005131 tRNA binding surface [nucleotide binding]; other site 517418005132 anticodon binding site; other site 517418005133 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 517418005134 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 517418005135 Domain of unknown function (DUF955); Region: DUF955; cl01076 517418005136 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 517418005137 Permease; Region: Permease; pfam02405 517418005138 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 517418005139 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 517418005140 Walker A/P-loop; other site 517418005141 ATP binding site [chemical binding]; other site 517418005142 Q-loop/lid; other site 517418005143 ABC transporter signature motif; other site 517418005144 Walker B; other site 517418005145 D-loop; other site 517418005146 H-loop/switch region; other site 517418005147 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 517418005148 mce related protein; Region: MCE; pfam02470 517418005149 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 517418005150 putative active site [active] 517418005151 putative metal binding residues [ion binding]; other site 517418005152 signature motif; other site 517418005153 putative triphosphate binding site [ion binding]; other site 517418005154 dimer interface [polypeptide binding]; other site 517418005155 DNA methylase; Region: N6_N4_Mtase; cl17433 517418005156 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 517418005157 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 517418005158 S-adenosylmethionine binding site [chemical binding]; other site 517418005159 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 517418005160 Beta-lactamase; Region: Beta-lactamase; pfam00144 517418005161 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418005162 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418005163 binding surface 517418005164 TPR motif; other site 517418005165 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 517418005166 MoxR-like ATPases [General function prediction only]; Region: COG0714 517418005167 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 517418005168 Walker A motif; other site 517418005169 ATP binding site [chemical binding]; other site 517418005170 Walker B motif; other site 517418005171 arginine finger; other site 517418005172 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 517418005173 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 517418005174 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 517418005175 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 517418005176 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 517418005177 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 517418005178 Response regulator receiver domain; Region: Response_reg; pfam00072 517418005179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418005180 active site 517418005181 phosphorylation site [posttranslational modification] 517418005182 intermolecular recognition site; other site 517418005183 dimerization interface [polypeptide binding]; other site 517418005184 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 517418005185 dimer interface [polypeptide binding]; other site 517418005186 phosphorylation site [posttranslational modification] 517418005187 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 517418005188 Found in ATP-dependent protease La (LON); Region: LON; smart00464 517418005189 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 517418005190 Walker A motif; other site 517418005191 ATP binding site [chemical binding]; other site 517418005192 Walker B motif; other site 517418005193 arginine finger; other site 517418005194 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 517418005195 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 517418005196 putative acyl-acceptor binding pocket; other site 517418005197 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 517418005198 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 517418005199 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 517418005200 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 517418005201 active site 517418005202 metal binding site [ion binding]; metal-binding site 517418005203 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 517418005204 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 517418005205 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 517418005206 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 517418005207 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 517418005208 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 517418005209 classical (c) SDRs; Region: SDR_c; cd05233 517418005210 NAD(P) binding site [chemical binding]; other site 517418005211 active site 517418005212 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 517418005213 FAD binding domain; Region: FAD_binding_4; pfam01565 517418005214 Divergent PAP2 family; Region: DUF212; pfam02681 517418005215 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 517418005216 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 517418005217 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 517418005218 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 517418005219 active site 517418005220 substrate binding site [chemical binding]; other site 517418005221 metal binding site [ion binding]; metal-binding site 517418005222 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 517418005223 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 517418005224 proline dehydrogenase; Region: PLN02681 517418005225 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 517418005226 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 517418005227 Walker A motif; other site 517418005228 ATP binding site [chemical binding]; other site 517418005229 Walker B motif; other site 517418005230 arginine finger; other site 517418005231 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 517418005232 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 517418005233 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 517418005234 active site 517418005235 lipoprotein signal peptidase; Provisional; Region: PRK14787 517418005236 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 517418005237 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 517418005238 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 517418005239 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 517418005240 shikimate binding site; other site 517418005241 NAD(P) binding site [chemical binding]; other site 517418005242 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418005243 binding surface 517418005244 TPR motif; other site 517418005245 TPR repeat; Region: TPR_11; pfam13414 517418005246 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418005247 binding surface 517418005248 TPR motif; other site 517418005249 Tetratricopeptide repeat; Region: TPR_16; pfam13432 517418005250 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418005251 binding surface 517418005252 TPR motif; other site 517418005253 TPR repeat; Region: TPR_11; pfam13414 517418005254 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 517418005255 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418005256 TPR repeat; Region: TPR_11; pfam13414 517418005257 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418005258 binding surface 517418005259 TPR motif; other site 517418005260 TPR repeat; Region: TPR_11; pfam13414 517418005261 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 517418005262 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 517418005263 active site 517418005264 dimer interface [polypeptide binding]; other site 517418005265 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 517418005266 dimer interface [polypeptide binding]; other site 517418005267 active site 517418005268 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 517418005269 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 517418005270 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418005271 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 517418005272 putative active site [active] 517418005273 heme pocket [chemical binding]; other site 517418005274 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 517418005275 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418005276 putative active site [active] 517418005277 heme pocket [chemical binding]; other site 517418005278 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 517418005279 dimer interface [polypeptide binding]; other site 517418005280 phosphorylation site [posttranslational modification] 517418005281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418005282 ATP binding site [chemical binding]; other site 517418005283 Mg2+ binding site [ion binding]; other site 517418005284 G-X-G motif; other site 517418005285 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 517418005286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418005287 active site 517418005288 phosphorylation site [posttranslational modification] 517418005289 intermolecular recognition site; other site 517418005290 dimerization interface [polypeptide binding]; other site 517418005291 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 517418005292 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 517418005293 oligomerisation interface [polypeptide binding]; other site 517418005294 mobile loop; other site 517418005295 roof hairpin; other site 517418005296 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 517418005297 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 517418005298 ring oligomerisation interface [polypeptide binding]; other site 517418005299 ATP/Mg binding site [chemical binding]; other site 517418005300 stacking interactions; other site 517418005301 hinge regions; other site 517418005302 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 517418005303 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 517418005304 RNA binding surface [nucleotide binding]; other site 517418005305 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 517418005306 active site 517418005307 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 517418005308 homotrimer interaction site [polypeptide binding]; other site 517418005309 putative active site [active] 517418005310 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 517418005311 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 517418005312 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 517418005313 EamA-like transporter family; Region: EamA; pfam00892 517418005314 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 517418005315 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 517418005316 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 517418005317 active site 517418005318 catalytic residues [active] 517418005319 metal binding site [ion binding]; metal-binding site 517418005320 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 517418005321 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 517418005322 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 517418005323 substrate binding site [chemical binding]; other site 517418005324 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 517418005325 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 517418005326 substrate binding site [chemical binding]; other site 517418005327 ligand binding site [chemical binding]; other site 517418005328 2-isopropylmalate synthase; Validated; Region: PRK00915 517418005329 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 517418005330 active site 517418005331 catalytic residues [active] 517418005332 metal binding site [ion binding]; metal-binding site 517418005333 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 517418005334 tartrate dehydrogenase; Region: TTC; TIGR02089 517418005335 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 517418005336 ketol-acid reductoisomerase; Provisional; Region: PRK05479 517418005337 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 517418005338 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 517418005339 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 517418005340 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 517418005341 putative valine binding site [chemical binding]; other site 517418005342 dimer interface [polypeptide binding]; other site 517418005343 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 517418005344 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 517418005345 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 517418005346 PYR/PP interface [polypeptide binding]; other site 517418005347 dimer interface [polypeptide binding]; other site 517418005348 TPP binding site [chemical binding]; other site 517418005349 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 517418005350 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 517418005351 TPP-binding site [chemical binding]; other site 517418005352 dimer interface [polypeptide binding]; other site 517418005353 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 517418005354 Response regulator receiver domain; Region: Response_reg; pfam00072 517418005355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418005356 active site 517418005357 phosphorylation site [posttranslational modification] 517418005358 intermolecular recognition site; other site 517418005359 dimerization interface [polypeptide binding]; other site 517418005360 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 517418005361 DsrC like protein; Region: DsrC; pfam04358 517418005362 Hemerythrin; Region: Hemerythrin; cd12107 517418005363 Fe binding site [ion binding]; other site 517418005364 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 517418005365 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 517418005366 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 517418005367 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 517418005368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 517418005369 dimer interface [polypeptide binding]; other site 517418005370 conserved gate region; other site 517418005371 putative PBP binding loops; other site 517418005372 ABC-ATPase subunit interface; other site 517418005373 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 517418005374 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 517418005375 peptide binding site [polypeptide binding]; other site 517418005376 Uncharacterized ACR, YagE family COG1723; Region: DUF155; pfam02582 517418005377 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 517418005378 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 517418005379 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 517418005380 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 517418005381 motif II; other site 517418005382 Predicted amidohydrolase [General function prediction only]; Region: COG0388 517418005383 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_8; cd07586 517418005384 putative active site [active] 517418005385 catalytic triad [active] 517418005386 putative dimer interface [polypeptide binding]; other site 517418005387 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 517418005388 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 517418005389 motif II; other site 517418005390 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 517418005391 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 517418005392 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 517418005393 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 517418005394 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 517418005395 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 517418005396 Gram-negative bacterial tonB protein; Region: TonB; cl10048 517418005397 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 517418005398 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 517418005399 dimer interface [polypeptide binding]; other site 517418005400 phosphorylation site [posttranslational modification] 517418005401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418005402 ATP binding site [chemical binding]; other site 517418005403 Mg2+ binding site [ion binding]; other site 517418005404 G-X-G motif; other site 517418005405 Response regulator receiver domain; Region: Response_reg; pfam00072 517418005406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418005407 active site 517418005408 phosphorylation site [posttranslational modification] 517418005409 intermolecular recognition site; other site 517418005410 dimerization interface [polypeptide binding]; other site 517418005411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418005412 Response regulator receiver domain; Region: Response_reg; pfam00072 517418005413 active site 517418005414 phosphorylation site [posttranslational modification] 517418005415 intermolecular recognition site; other site 517418005416 dimerization interface [polypeptide binding]; other site 517418005417 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 517418005418 CheB methylesterase; Region: CheB_methylest; pfam01339 517418005419 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 517418005420 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 517418005421 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 517418005422 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 517418005423 PAS domain; Region: PAS_10; pfam13596 517418005424 PAS fold; Region: PAS_3; pfam08447 517418005425 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 517418005426 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418005427 PAS fold; Region: PAS_3; pfam08447 517418005428 putative active site [active] 517418005429 heme pocket [chemical binding]; other site 517418005430 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 517418005431 dimer interface [polypeptide binding]; other site 517418005432 phosphorylation site [posttranslational modification] 517418005433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418005434 ATP binding site [chemical binding]; other site 517418005435 Mg2+ binding site [ion binding]; other site 517418005436 G-X-G motif; other site 517418005437 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 517418005438 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 517418005439 active site 517418005440 catalytic residues [active] 517418005441 metal binding site [ion binding]; metal-binding site 517418005442 Nif-specific regulatory protein; Region: nifA; TIGR01817 517418005443 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 517418005444 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 517418005445 Walker A motif; other site 517418005446 ATP binding site [chemical binding]; other site 517418005447 Walker B motif; other site 517418005448 arginine finger; other site 517418005449 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 517418005450 peroxiredoxin; Provisional; Region: PRK13189 517418005451 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 517418005452 dimer interface [polypeptide binding]; other site 517418005453 decamer (pentamer of dimers) interface [polypeptide binding]; other site 517418005454 catalytic triad [active] 517418005455 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 517418005456 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 517418005457 catalytic residue [active] 517418005458 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 517418005459 active site 517418005460 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 517418005461 active site 517418005462 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 517418005463 binding surface 517418005464 TPR motif; other site 517418005465 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418005466 PspC domain; Region: PspC; pfam04024 517418005467 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 517418005468 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 517418005469 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 517418005470 FeS/SAM binding site; other site 517418005471 TRAM domain; Region: TRAM; cl01282 517418005472 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 517418005473 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 517418005474 Cation efflux family; Region: Cation_efflux; cl00316 517418005475 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 517418005476 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 517418005477 anti sigma factor interaction site; other site 517418005478 regulatory phosphorylation site [posttranslational modification]; other site 517418005479 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 517418005480 Bacterial Ig-like domain; Region: Big_5; pfam13205 517418005481 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 517418005482 glycogen synthase; Provisional; Region: glgA; PRK00654 517418005483 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 517418005484 ADP-binding pocket [chemical binding]; other site 517418005485 homodimer interface [polypeptide binding]; other site 517418005486 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 517418005487 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 517418005488 active site 517418005489 motif I; other site 517418005490 motif II; other site 517418005491 TGF-beta propeptide; Region: TGFb_propeptide; pfam00688 517418005492 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 517418005493 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 517418005494 generic binding surface II; other site 517418005495 generic binding surface I; other site 517418005496 DNA repair protein RadA; Provisional; Region: PRK11823 517418005497 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 517418005498 Walker A motif/ATP binding site; other site 517418005499 ATP binding site [chemical binding]; other site 517418005500 Walker B motif; other site 517418005501 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 517418005502 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 517418005503 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 517418005504 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 517418005505 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 517418005506 HlyD family secretion protein; Region: HlyD_3; pfam13437 517418005507 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 517418005508 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 517418005509 WHG domain; Region: WHG; pfam13305 517418005510 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 517418005511 ligand binding site [chemical binding]; other site 517418005512 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 517418005513 substrate binding site [chemical binding]; other site 517418005514 multimerization interface [polypeptide binding]; other site 517418005515 ATP binding site [chemical binding]; other site 517418005516 GTP-binding protein YchF; Reviewed; Region: PRK09601 517418005517 YchF GTPase; Region: YchF; cd01900 517418005518 G1 box; other site 517418005519 GTP/Mg2+ binding site [chemical binding]; other site 517418005520 Switch I region; other site 517418005521 G2 box; other site 517418005522 Switch II region; other site 517418005523 G3 box; other site 517418005524 G4 box; other site 517418005525 G5 box; other site 517418005526 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 517418005527 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 517418005528 putative metal binding site [ion binding]; other site 517418005529 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 517418005530 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 517418005531 metal binding site [ion binding]; metal-binding site 517418005532 dimer interface [polypeptide binding]; other site 517418005533 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 517418005534 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 517418005535 hexamer interface [polypeptide binding]; other site 517418005536 ligand binding site [chemical binding]; other site 517418005537 putative active site [active] 517418005538 NAD(P) binding site [chemical binding]; other site 517418005539 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 517418005540 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 517418005541 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 517418005542 primosomal protein N' Region: priA; TIGR00595 517418005543 ATP binding site [chemical binding]; other site 517418005544 putative Mg++ binding site [ion binding]; other site 517418005545 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 517418005546 ATP-binding site [chemical binding]; other site 517418005547 phytoene desaturase; Region: phytoene_desat; TIGR02731 517418005548 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 517418005549 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 517418005550 magnesium chelatase, H subunit; Region: BchH; TIGR02025 517418005551 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 517418005552 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 517418005553 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 517418005554 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 517418005555 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 517418005556 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 517418005557 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 517418005558 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 517418005559 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 517418005560 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 517418005561 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 517418005562 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 517418005563 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 517418005564 Walker A/P-loop; other site 517418005565 ATP binding site [chemical binding]; other site 517418005566 Q-loop/lid; other site 517418005567 ABC transporter signature motif; other site 517418005568 Walker B; other site 517418005569 D-loop; other site 517418005570 H-loop/switch region; other site 517418005571 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418005572 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418005573 binding surface 517418005574 TPR motif; other site 517418005575 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418005576 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 517418005577 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 517418005578 dimer interface [polypeptide binding]; other site 517418005579 phosphorylation site [posttranslational modification] 517418005580 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418005581 ATP binding site [chemical binding]; other site 517418005582 Mg2+ binding site [ion binding]; other site 517418005583 G-X-G motif; other site 517418005584 Response regulator receiver domain; Region: Response_reg; pfam00072 517418005585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418005586 active site 517418005587 phosphorylation site [posttranslational modification] 517418005588 intermolecular recognition site; other site 517418005589 dimerization interface [polypeptide binding]; other site 517418005590 Response regulator receiver domain; Region: Response_reg; pfam00072 517418005591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418005592 active site 517418005593 phosphorylation site [posttranslational modification] 517418005594 intermolecular recognition site; other site 517418005595 dimerization interface [polypeptide binding]; other site 517418005596 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 517418005597 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 517418005598 active site 517418005599 catalytic site [active] 517418005600 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 517418005601 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 517418005602 dimer interface [polypeptide binding]; other site 517418005603 catalytic residue [active] 517418005604 metal binding site [ion binding]; metal-binding site 517418005605 Uncharacterized conserved protein [Function unknown]; Region: COG0432 517418005606 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 517418005607 TrkA-N domain; Region: TrkA_N; pfam02254 517418005608 TrkA-C domain; Region: TrkA_C; pfam02080 517418005609 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 517418005610 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 517418005611 Predicted permeases [General function prediction only]; Region: COG0795 517418005612 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 517418005613 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 517418005614 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_1; cd03400 517418005615 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 517418005616 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 517418005617 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 517418005618 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 517418005619 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 517418005620 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 517418005621 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 517418005622 Walker A/P-loop; other site 517418005623 ATP binding site [chemical binding]; other site 517418005624 Q-loop/lid; other site 517418005625 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 517418005626 ABC transporter signature motif; other site 517418005627 Walker B; other site 517418005628 D-loop; other site 517418005629 H-loop/switch region; other site 517418005630 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 517418005631 Radical SAM superfamily; Region: Radical_SAM; pfam04055 517418005632 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 517418005633 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 517418005634 TPR motif; other site 517418005635 binding surface 517418005636 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418005637 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418005638 binding surface 517418005639 TPR motif; other site 517418005640 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418005641 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 517418005642 active site 517418005643 catalytic triad [active] 517418005644 Family description; Region: VCBS; pfam13517 517418005645 Fibronectin type 3 domain; Region: FN3; smart00060 517418005646 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 517418005647 Domain of unknown function (DUF386); Region: DUF386; cl01047 517418005648 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418005649 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418005650 TPR motif; other site 517418005651 binding surface 517418005652 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418005653 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418005654 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418005655 binding surface 517418005656 TPR motif; other site 517418005657 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418005658 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418005659 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 517418005660 binding surface 517418005661 TPR motif; other site 517418005662 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 517418005663 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 517418005664 metal binding site [ion binding]; metal-binding site 517418005665 active site 517418005666 I-site; other site 517418005667 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 517418005668 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 517418005669 active site 517418005670 HIGH motif; other site 517418005671 KMSKS motif; other site 517418005672 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 517418005673 tRNA binding surface [nucleotide binding]; other site 517418005674 anticodon binding site; other site 517418005675 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 517418005676 dimer interface [polypeptide binding]; other site 517418005677 putative tRNA-binding site [nucleotide binding]; other site 517418005678 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 517418005679 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 517418005680 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 517418005681 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 517418005682 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 517418005683 Predicted transcriptional regulator [Transcription]; Region: COG2378 517418005684 WYL domain; Region: WYL; pfam13280 517418005685 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 517418005686 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 517418005687 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 517418005688 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 517418005689 Cna protein B-type domain; Region: Cna_B_2; pfam13715 517418005690 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 517418005691 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 517418005692 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 517418005693 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 517418005694 AIR carboxylase; Region: AIRC; pfam00731 517418005695 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 517418005696 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 517418005697 NAD binding site [chemical binding]; other site 517418005698 ATP-grasp domain; Region: ATP-grasp; pfam02222 517418005699 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 517418005700 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 517418005701 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 517418005702 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 517418005703 ligand binding site [chemical binding]; other site 517418005704 IncA protein; Region: IncA; pfam04156 517418005705 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 517418005706 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 517418005707 putative NADP binding site [chemical binding]; other site 517418005708 putative substrate binding site [chemical binding]; other site 517418005709 active site 517418005710 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 517418005711 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 517418005712 ligand binding site [chemical binding]; other site 517418005713 flexible hinge region; other site 517418005714 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 517418005715 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 517418005716 metal binding triad; other site 517418005717 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 517418005718 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 517418005719 active site 517418005720 catalytic site [active] 517418005721 substrate binding site [chemical binding]; other site 517418005722 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 517418005723 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 517418005724 SLBB domain; Region: SLBB; pfam10531 517418005725 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 517418005726 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 517418005727 FMN-binding domain; Region: FMN_bind; cl01081 517418005728 electron transport complex RsxE subunit; Provisional; Region: PRK12405 517418005729 electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943 517418005730 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 517418005731 ApbE family; Region: ApbE; pfam02424 517418005732 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 517418005733 ferredoxin; Validated; Region: PRK07118 517418005734 Putative Fe-S cluster; Region: FeS; cl17515 517418005735 4Fe-4S binding domain; Region: Fer4; pfam00037 517418005736 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 517418005737 recombination factor protein RarA; Reviewed; Region: PRK13342 517418005738 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 517418005739 Walker A motif; other site 517418005740 ATP binding site [chemical binding]; other site 517418005741 Walker B motif; other site 517418005742 arginine finger; other site 517418005743 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 517418005744 NAD synthetase; Provisional; Region: PRK13980 517418005745 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 517418005746 homodimer interface [polypeptide binding]; other site 517418005747 NAD binding pocket [chemical binding]; other site 517418005748 ATP binding pocket [chemical binding]; other site 517418005749 Mg binding site [ion binding]; other site 517418005750 active-site loop [active] 517418005751 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 517418005752 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 517418005753 putative ribose interaction site [chemical binding]; other site 517418005754 putative ADP binding site [chemical binding]; other site 517418005755 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 517418005756 active site 517418005757 catalytic triad [active] 517418005758 oxyanion hole [active] 517418005759 switch loop; other site 517418005760 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 517418005761 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 517418005762 Walker A/P-loop; other site 517418005763 ATP binding site [chemical binding]; other site 517418005764 Q-loop/lid; other site 517418005765 ABC transporter signature motif; other site 517418005766 Walker B; other site 517418005767 D-loop; other site 517418005768 H-loop/switch region; other site 517418005769 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 517418005770 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 517418005771 FtsX-like permease family; Region: FtsX; pfam02687 517418005772 competence damage-inducible protein A; Provisional; Region: PRK00549 517418005773 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 517418005774 putative MPT binding site; other site 517418005775 Competence-damaged protein; Region: CinA; pfam02464 517418005776 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 517418005777 GAF domain; Region: GAF; pfam01590 517418005778 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 517418005779 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 517418005780 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 517418005781 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 517418005782 Zn2+ binding site [ion binding]; other site 517418005783 Mg2+ binding site [ion binding]; other site 517418005784 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 517418005785 alanine racemase; Reviewed; Region: alr; PRK00053 517418005786 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 517418005787 active site 517418005788 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 517418005789 dimer interface [polypeptide binding]; other site 517418005790 substrate binding site [chemical binding]; other site 517418005791 catalytic residues [active] 517418005792 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 517418005793 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 517418005794 Predicted ATPase [General function prediction only]; Region: COG4637 517418005795 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 517418005796 Walker A/P-loop; other site 517418005797 ATP binding site [chemical binding]; other site 517418005798 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 517418005799 Walker B; other site 517418005800 D-loop; other site 517418005801 H-loop/switch region; other site 517418005802 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418005803 binding surface 517418005804 TPR repeat; Region: TPR_11; pfam13414 517418005805 TPR motif; other site 517418005806 TPR repeat; Region: TPR_11; pfam13414 517418005807 TPR repeat; Region: TPR_11; pfam13414 517418005808 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418005809 binding surface 517418005810 TPR motif; other site 517418005811 TPR repeat; Region: TPR_11; pfam13414 517418005812 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418005813 TPR motif; other site 517418005814 binding surface 517418005815 TPR repeat; Region: TPR_11; pfam13414 517418005816 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 517418005817 putative dimer interface [polypeptide binding]; other site 517418005818 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 517418005819 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 517418005820 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 517418005821 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 517418005822 metal ion-dependent adhesion site (MIDAS); other site 517418005823 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 517418005824 CHAT domain; Region: CHAT; cl17868 517418005825 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 517418005826 Prephenate dehydratase; Region: PDT; pfam00800 517418005827 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 517418005828 putative L-Phe binding site [chemical binding]; other site 517418005829 hypothetical protein; Validated; Region: PRK00110 517418005830 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 517418005831 active site 517418005832 putative DNA-binding cleft [nucleotide binding]; other site 517418005833 dimer interface [polypeptide binding]; other site 517418005834 TspO/MBR family; Region: TspO_MBR; cl01379 517418005835 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 517418005836 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 517418005837 NAD binding site [chemical binding]; other site 517418005838 substrate binding site [chemical binding]; other site 517418005839 homodimer interface [polypeptide binding]; other site 517418005840 active site 517418005841 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 517418005842 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 517418005843 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 517418005844 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 517418005845 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 517418005846 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 517418005847 Substrate binding site; other site 517418005848 Mg++ binding site; other site 517418005849 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 517418005850 tetramerization interface [polypeptide binding]; other site 517418005851 active site 517418005852 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 517418005853 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 517418005854 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 517418005855 periplasmic chaperone; Provisional; Region: PRK10780 517418005856 Bifunctional nuclease; Region: DNase-RNase; pfam02577 517418005857 UvrB/uvrC motif; Region: UVR; pfam02151 517418005858 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 517418005859 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 517418005860 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 517418005861 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 517418005862 Ligand binding site [chemical binding]; other site 517418005863 Electron transfer flavoprotein domain; Region: ETF; pfam01012 517418005864 Ion transport protein; Region: Ion_trans; pfam00520 517418005865 Ion channel; Region: Ion_trans_2; pfam07885 517418005866 Double zinc ribbon; Region: DZR; pfam12773 517418005867 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 517418005868 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 517418005869 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 517418005870 Walker A/P-loop; other site 517418005871 ATP binding site [chemical binding]; other site 517418005872 Q-loop/lid; other site 517418005873 ABC transporter signature motif; other site 517418005874 Walker B; other site 517418005875 D-loop; other site 517418005876 H-loop/switch region; other site 517418005877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 517418005878 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 517418005879 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 517418005880 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 517418005881 Ligand binding site; other site 517418005882 Putative Catalytic site; other site 517418005883 DXD motif; other site 517418005884 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 517418005885 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 517418005886 active site 517418005887 substrate binding site [chemical binding]; other site 517418005888 Mg2+ binding site [ion binding]; other site 517418005889 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 517418005890 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 517418005891 GatB domain; Region: GatB_Yqey; smart00845 517418005892 Clp amino terminal domain; Region: Clp_N; pfam02861 517418005893 Clp amino terminal domain; Region: Clp_N; pfam02861 517418005894 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 517418005895 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 517418005896 Walker A motif; other site 517418005897 ATP binding site [chemical binding]; other site 517418005898 Walker B motif; other site 517418005899 arginine finger; other site 517418005900 DoxX-like family; Region: DoxX_3; pfam13781 517418005901 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 517418005902 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 517418005903 Substrate binding site; other site 517418005904 Cupin domain; Region: Cupin_2; cl17218 517418005905 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418005906 Tetratricopeptide repeat; Region: TPR_16; pfam13432 517418005907 TPR motif; other site 517418005908 binding surface 517418005909 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418005910 TPR motif; other site 517418005911 TPR repeat; Region: TPR_11; pfam13414 517418005912 binding surface 517418005913 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418005914 binding surface 517418005915 TPR motif; other site 517418005916 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 517418005917 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 517418005918 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 517418005919 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 517418005920 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 517418005921 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 517418005922 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 517418005923 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 517418005924 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 517418005925 ligand binding site [chemical binding]; other site 517418005926 flexible hinge region; other site 517418005927 pteridine reductase; Provisional; Region: PRK09135 517418005928 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 517418005929 NAD(P) binding site [chemical binding]; other site 517418005930 active site 517418005931 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 517418005932 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 517418005933 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 517418005934 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 517418005935 GrpE; Region: GrpE; pfam01025 517418005936 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 517418005937 dimer interface [polypeptide binding]; other site 517418005938 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 517418005939 chaperone protein DnaJ; Provisional; Region: PRK14281 517418005940 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 517418005941 HSP70 interaction site [polypeptide binding]; other site 517418005942 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 517418005943 Zn binding sites [ion binding]; other site 517418005944 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 517418005945 dimer interface [polypeptide binding]; other site 517418005946 HupF/HypC family; Region: HupF_HypC; pfam01455 517418005947 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 517418005948 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 517418005949 Predicted membrane protein [Function unknown]; Region: COG2855 517418005950 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 517418005951 nitrogenase iron protein; Region: nifH; TIGR01287 517418005952 Nucleotide-binding sites [chemical binding]; other site 517418005953 Walker A motif; other site 517418005954 Switch I region of nucleotide binding site; other site 517418005955 Fe4S4 binding sites [ion binding]; other site 517418005956 Switch II region of nucleotide binding site; other site 517418005957 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 517418005958 Nitrogen regulatory protein P-II; Region: P-II; smart00938 517418005959 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 517418005960 Nitrogen regulatory protein P-II; Region: P-II; smart00938 517418005961 nitrogenase iron-iron protein, alpha chain; Region: ANFD; TIGR01861 517418005962 Nitrogenase_VFe_alpha -like: Nitrogenase VFe protein, alpha subunit like. This group contains proteins similar to the alpha subunits of, the VFe protein of the vanadium-dependent (V-) nitrogenase and the FeFe protein of the iron only (Fe-) nitrogenase...; Region: Nitrogenase_VFe_alpha; cd01977 517418005963 Vanadium/alternative nitrogenase delta subunit; Region: AnfG_VnfG; pfam03139 517418005964 Nitrogenase_VFe_beta -like: Nitrogenase VFe protein, beta subunit like. This group contains proteins similar to the beta subunits of the VFe protein of the vanadium-dependent (V-) nitrogenase. Nitrogenase catalyzes the ATP-dependent reduction of...; Region: Nitrogenase_VFe_beta_like; cd01973 517418005965 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 517418005966 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 517418005967 Iron only nitrogenase protein AnfO (AnfO_nitrog); Region: AnfO_nitrog; cl17112 517418005968 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 517418005969 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 517418005970 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 517418005971 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 517418005972 Walker A motif; other site 517418005973 ATP binding site [chemical binding]; other site 517418005974 Walker B motif; other site 517418005975 arginine finger; other site 517418005976 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 517418005977 Transcriptional regulator [Transcription]; Region: LysR; COG0583 517418005978 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 517418005979 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 517418005980 putative dimerization interface [polypeptide binding]; other site 517418005981 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 517418005982 dimerization interface [polypeptide binding]; other site 517418005983 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 517418005984 ATP binding site [chemical binding]; other site 517418005985 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 517418005986 active site 517418005987 dimerization interface [polypeptide binding]; other site 517418005988 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 517418005989 active site 517418005990 hydrophilic channel; other site 517418005991 dimerization interface [polypeptide binding]; other site 517418005992 catalytic residues [active] 517418005993 active site lid [active] 517418005994 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 517418005995 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 517418005996 putative phosphate acyltransferase; Provisional; Region: PRK05331 517418005997 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 517418005998 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 517418005999 4Fe-4S binding domain; Region: Fer4; pfam00037 517418006000 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 517418006001 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 517418006002 molybdopterin cofactor binding site; other site 517418006003 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 517418006004 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 517418006005 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 517418006006 putative molybdopterin cofactor binding site; other site 517418006007 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 517418006008 putative active site [active] 517418006009 dimerization interface [polypeptide binding]; other site 517418006010 putative tRNAtyr binding site [nucleotide binding]; other site 517418006011 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 517418006012 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 517418006013 Ligand binding site; other site 517418006014 oligomer interface; other site 517418006015 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 517418006016 homotrimer interaction site [polypeptide binding]; other site 517418006017 putative active site [active] 517418006018 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 517418006019 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 517418006020 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 517418006021 Methyltransferase domain; Region: Methyltransf_31; pfam13847 517418006022 S-adenosylmethionine binding site [chemical binding]; other site 517418006023 fumarate hydratase; Reviewed; Region: fumC; PRK00485 517418006024 Class II fumarases; Region: Fumarase_classII; cd01362 517418006025 active site 517418006026 tetramer interface [polypeptide binding]; other site 517418006027 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 517418006028 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 517418006029 Walker A/P-loop; other site 517418006030 ATP binding site [chemical binding]; other site 517418006031 Q-loop/lid; other site 517418006032 ABC transporter signature motif; other site 517418006033 Walker B; other site 517418006034 D-loop; other site 517418006035 H-loop/switch region; other site 517418006036 ABC transporter; Region: ABC_tran_2; pfam12848 517418006037 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 517418006038 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 517418006039 Zn2+ binding site [ion binding]; other site 517418006040 Mg2+ binding site [ion binding]; other site 517418006041 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 517418006042 catalytic core [active] 517418006043 polyphosphate kinase; Provisional; Region: PRK05443 517418006044 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 517418006045 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 517418006046 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 517418006047 domain interface [polypeptide binding]; other site 517418006048 active site 517418006049 catalytic site [active] 517418006050 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 517418006051 domain interface [polypeptide binding]; other site 517418006052 active site 517418006053 catalytic site [active] 517418006054 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 517418006055 Ferritin-like domain; Region: Ferritin; pfam00210 517418006056 ferroxidase diiron center [ion binding]; other site 517418006057 Preprotein translocase SecG subunit; Region: SecG; pfam03840 517418006058 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 517418006059 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 517418006060 putative active site pocket [active] 517418006061 4-fold oligomerization interface [polypeptide binding]; other site 517418006062 metal binding residues [ion binding]; metal-binding site 517418006063 3-fold/trimer interface [polypeptide binding]; other site 517418006064 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 517418006065 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 517418006066 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 517418006067 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 517418006068 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 517418006069 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 517418006070 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 517418006071 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 517418006072 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 517418006073 ligand binding site [chemical binding]; other site 517418006074 NHL repeat; Region: NHL; pfam01436 517418006075 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 517418006076 N-acetyl-D-glucosamine binding site [chemical binding]; other site 517418006077 catalytic residue [active] 517418006078 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 517418006079 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 517418006080 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 517418006081 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 517418006082 glutamine binding [chemical binding]; other site 517418006083 catalytic triad [active] 517418006084 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 517418006085 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 517418006086 Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635 517418006087 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 517418006088 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 517418006089 Photosystem P840 reaction-centre cytochrome c-551; Region: Cytochrome-c551; pfam10643 517418006090 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 517418006091 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 517418006092 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 517418006093 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 517418006094 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 517418006095 Hexamer interface [polypeptide binding]; other site 517418006096 Hexagonal pore residue; other site 517418006097 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 517418006098 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 517418006099 Hexamer interface [polypeptide binding]; other site 517418006100 Putative hexagonal pore residue; other site 517418006101 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 517418006102 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 517418006103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 517418006104 S-adenosylmethionine binding site [chemical binding]; other site 517418006105 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 517418006106 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 517418006107 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 517418006108 active site 517418006109 metal binding site [ion binding]; metal-binding site 517418006110 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 517418006111 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 517418006112 HlyD family secretion protein; Region: HlyD_3; pfam13437 517418006113 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 517418006114 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 517418006115 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 517418006116 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 517418006117 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 517418006118 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 517418006119 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 517418006120 Two component regulator propeller; Region: Reg_prop; pfam07494 517418006121 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 517418006122 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 517418006123 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 517418006124 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 517418006125 dimer interface [polypeptide binding]; other site 517418006126 phosphorylation site [posttranslational modification] 517418006127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418006128 ATP binding site [chemical binding]; other site 517418006129 Mg2+ binding site [ion binding]; other site 517418006130 G-X-G motif; other site 517418006131 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 517418006132 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 517418006133 Na binding site [ion binding]; other site 517418006134 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 517418006135 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 517418006136 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 517418006137 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 517418006138 Zn2+ binding site [ion binding]; other site 517418006139 Mg2+ binding site [ion binding]; other site 517418006140 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 517418006141 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 517418006142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 517418006143 Walker A/P-loop; other site 517418006144 ATP binding site [chemical binding]; other site 517418006145 Q-loop/lid; other site 517418006146 ABC transporter signature motif; other site 517418006147 Walker B; other site 517418006148 D-loop; other site 517418006149 H-loop/switch region; other site 517418006150 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 517418006151 Helix-turn-helix domain; Region: HTH_18; pfam12833 517418006152 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 517418006153 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 517418006154 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 517418006155 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 517418006156 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 517418006157 diaminopimelate decarboxylase; Region: lysA; TIGR01048 517418006158 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme MccE; Region: PLPDE_III_MccE_like; cd06841 517418006159 dimer interface [polypeptide binding]; other site 517418006160 active site 517418006161 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 517418006162 catalytic residues [active] 517418006163 substrate binding site [chemical binding]; other site 517418006164 Urea transporter; Region: UT; pfam03253 517418006165 Peptidase family M23; Region: Peptidase_M23; pfam01551 517418006166 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 517418006167 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418006168 binding surface 517418006169 TPR motif; other site 517418006170 TPR repeat; Region: TPR_11; pfam13414 517418006171 Tetratricopeptide repeat; Region: TPR_16; pfam13432 517418006172 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 517418006173 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 517418006174 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 517418006175 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 517418006176 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 517418006177 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 517418006178 Surface antigen; Region: Bac_surface_Ag; pfam01103 517418006179 Uncharacterized conserved protein [Function unknown]; Region: COG5276 517418006180 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 517418006181 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 517418006182 S-adenosylmethionine synthetase; Validated; Region: PRK05250 517418006183 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 517418006184 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 517418006185 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 517418006186 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 517418006187 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 517418006188 homotetramer interface [polypeptide binding]; other site 517418006189 ligand binding site [chemical binding]; other site 517418006190 catalytic site [active] 517418006191 NAD binding site [chemical binding]; other site 517418006192 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 517418006193 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 517418006194 active site 517418006195 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 517418006196 generic binding surface II; other site 517418006197 generic binding surface I; other site 517418006198 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 517418006199 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 517418006200 catalytic residues [active] 517418006201 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 517418006202 catalytic residues [active] 517418006203 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 517418006204 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 517418006205 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 517418006206 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 517418006207 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 517418006208 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 517418006209 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 517418006210 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 517418006211 tol-pal system protein YbgF; Provisional; Region: PRK10803 517418006212 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 517418006213 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493 517418006214 Na binding site [ion binding]; other site 517418006215 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 517418006216 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 517418006217 anti sigma factor interaction site; other site 517418006218 regulatory phosphorylation site [posttranslational modification]; other site 517418006219 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 517418006220 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 517418006221 Transposase [DNA replication, recombination, and repair]; Region: COG5433 517418006222 Transposase [DNA replication, recombination, and repair]; Region: COG5433 517418006223 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 517418006224 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 517418006225 ligand binding site [chemical binding]; other site 517418006226 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 517418006227 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 517418006228 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 517418006229 catalytic core [active] 517418006230 Maf-like protein; Reviewed; Region: PRK00078 517418006231 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 517418006232 active site 517418006233 dimer interface [polypeptide binding]; other site 517418006234 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 517418006235 Na binding site [ion binding]; other site 517418006236 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 517418006237 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 517418006238 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 517418006239 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 517418006240 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 517418006241 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 517418006242 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 517418006243 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 517418006244 Leucine rich repeat; Region: LRR_8; pfam13855 517418006245 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 517418006246 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 517418006247 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 517418006248 putative acyl-acceptor binding pocket; other site 517418006249 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 517418006250 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 517418006251 active site 517418006252 HIGH motif; other site 517418006253 nucleotide binding site [chemical binding]; other site 517418006254 Family of unknown function (DUF490); Region: DUF490; pfam04357 517418006255 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 517418006256 Flavoprotein; Region: Flavoprotein; pfam02441 517418006257 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 517418006258 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 517418006259 Fe-S cluster binding site [ion binding]; other site 517418006260 active site 517418006261 replicative DNA helicase; Region: DnaB; TIGR00665 517418006262 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 517418006263 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 517418006264 Walker A motif; other site 517418006265 ATP binding site [chemical binding]; other site 517418006266 Walker B motif; other site 517418006267 DNA binding loops [nucleotide binding] 517418006268 SusE outer membrane protein; Region: SusE; pfam14292 517418006269 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 517418006270 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418006271 active site 517418006272 phosphorylation site [posttranslational modification] 517418006273 intermolecular recognition site; other site 517418006274 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 517418006275 Walker A motif; other site 517418006276 ATP binding site [chemical binding]; other site 517418006277 Walker B motif; other site 517418006278 arginine finger; other site 517418006279 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 517418006280 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 517418006281 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 517418006282 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 517418006283 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 517418006284 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 517418006285 putative active site [active] 517418006286 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 517418006287 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 517418006288 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 517418006289 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 517418006290 putative catalytic residue [active] 517418006291 fructokinase; Reviewed; Region: PRK09557 517418006292 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 517418006293 nucleotide binding site [chemical binding]; other site 517418006294 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 517418006295 Protein of unknown function; Region: DUF3971; pfam13116 517418006296 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 517418006297 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 517418006298 proline aminopeptidase P II; Provisional; Region: PRK10879 517418006299 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 517418006300 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 517418006301 active site 517418006302 TRAM domain; Region: TRAM; cl01282 517418006303 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 517418006304 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 517418006305 S-adenosylmethionine binding site [chemical binding]; other site 517418006306 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 517418006307 UbiA prenyltransferase family; Region: UbiA; pfam01040 517418006308 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 517418006309 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 517418006310 dimer interface [polypeptide binding]; other site 517418006311 active site 517418006312 glycine-pyridoxal phosphate binding site [chemical binding]; other site 517418006313 folate binding site [chemical binding]; other site 517418006314 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 517418006315 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 517418006316 domain interfaces; other site 517418006317 active site 517418006318 YibE/F-like protein; Region: YibE_F; pfam07907 517418006319 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 517418006320 active site 517418006321 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 517418006322 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 517418006323 putative NAD(P) binding site [chemical binding]; other site 517418006324 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 517418006325 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 517418006326 AAA domain; Region: AAA_18; pfam13238 517418006327 homotrimer interface [polypeptide binding]; other site 517418006328 Walker A motif; other site 517418006329 GTP binding site [chemical binding]; other site 517418006330 Walker B motif; other site 517418006331 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 517418006332 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 517418006333 putative dimer interface [polypeptide binding]; other site 517418006334 [2Fe-2S] cluster binding site [ion binding]; other site 517418006335 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 517418006336 NADH dehydrogenase subunit D; Validated; Region: PRK06075 517418006337 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 517418006338 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 517418006339 NADH dehydrogenase subunit B; Validated; Region: PRK06411 517418006340 Methyltransferase domain; Region: Methyltransf_23; pfam13489 517418006341 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 517418006342 S-adenosylmethionine binding site [chemical binding]; other site 517418006343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 517418006344 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 517418006345 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 517418006346 nucleotide binding site/active site [active] 517418006347 HIT family signature motif; other site 517418006348 catalytic residue [active] 517418006349 GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441 517418006350 GIY-YIG motif/motif A; other site 517418006351 putative active site [active] 517418006352 putative metal binding site [ion binding]; other site 517418006353 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 517418006354 hypothetical protein; Reviewed; Region: PRK09588 517418006355 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 517418006356 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 517418006357 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 517418006358 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 517418006359 protein binding site [polypeptide binding]; other site 517418006360 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 517418006361 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 517418006362 Walker A/P-loop; other site 517418006363 ATP binding site [chemical binding]; other site 517418006364 Q-loop/lid; other site 517418006365 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 517418006366 ABC transporter signature motif; other site 517418006367 Walker B; other site 517418006368 D-loop; other site 517418006369 H-loop/switch region; other site 517418006370 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 517418006371 dihydrodipicolinate synthase; Region: dapA; TIGR00674 517418006372 dimer interface [polypeptide binding]; other site 517418006373 active site 517418006374 catalytic residue [active] 517418006375 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 517418006376 Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers; Region: iodotyrosine_dehalogenase; cd02144 517418006377 putative FMN binding site [chemical binding]; other site 517418006378 putative dimer interface [polypeptide binding]; other site 517418006379 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 517418006380 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 517418006381 tetramer interface [polypeptide binding]; other site 517418006382 pyridoxal 5'-phosphate binding site [chemical binding]; other site 517418006383 catalytic residue [active] 517418006384 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 517418006385 lipoyl attachment site [posttranslational modification]; other site 517418006386 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 517418006387 O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923 517418006388 acyl-activating enzyme (AAE) consensus motif; other site 517418006389 putative AMP binding site [chemical binding]; other site 517418006390 putative active site [active] 517418006391 putative CoA binding site [chemical binding]; other site 517418006392 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 517418006393 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 517418006394 active site 517418006395 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 517418006396 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 517418006397 substrate binding site [chemical binding]; other site 517418006398 oxyanion hole (OAH) forming residues; other site 517418006399 trimer interface [polypeptide binding]; other site 517418006400 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 517418006401 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 517418006402 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 517418006403 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 517418006404 dimer interface [polypeptide binding]; other site 517418006405 tetramer interface [polypeptide binding]; other site 517418006406 PYR/PP interface [polypeptide binding]; other site 517418006407 TPP binding site [chemical binding]; other site 517418006408 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 517418006409 TPP-binding site; other site 517418006410 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 517418006411 chorismate binding enzyme; Region: Chorismate_bind; cl10555 517418006412 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 517418006413 Interdomain contacts; other site 517418006414 Cytokine receptor motif; other site 517418006415 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 517418006416 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 517418006417 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 517418006418 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 517418006419 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 517418006420 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 517418006421 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 517418006422 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 517418006423 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 517418006424 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 517418006425 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 517418006426 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 517418006427 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 517418006428 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 517418006429 active site 517418006430 dimer interface [polypeptide binding]; other site 517418006431 motif 1; other site 517418006432 motif 2; other site 517418006433 motif 3; other site 517418006434 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 517418006435 anticodon binding site; other site 517418006436 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 517418006437 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 517418006438 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 517418006439 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 517418006440 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 517418006441 23S rRNA binding site [nucleotide binding]; other site 517418006442 L21 binding site [polypeptide binding]; other site 517418006443 L13 binding site [polypeptide binding]; other site 517418006444 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 517418006445 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 517418006446 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 517418006447 dimer interface [polypeptide binding]; other site 517418006448 motif 1; other site 517418006449 active site 517418006450 motif 2; other site 517418006451 motif 3; other site 517418006452 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 517418006453 active site 517418006454 catalytic triad [active] 517418006455 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 517418006456 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 517418006457 DNA methylase; Region: N6_N4_Mtase; cl17433 517418006458 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 517418006459 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 517418006460 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 517418006461 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 517418006462 Coenzyme A binding pocket [chemical binding]; other site 517418006463 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 517418006464 SLBB domain; Region: SLBB; pfam10531 517418006465 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 517418006466 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 517418006467 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 517418006468 catalytic loop [active] 517418006469 iron binding site [ion binding]; other site 517418006470 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 517418006471 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 517418006472 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 517418006473 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 517418006474 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418006475 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 517418006476 putative active site [active] 517418006477 heme pocket [chemical binding]; other site 517418006478 PAS domain; Region: PAS_8; pfam13188 517418006479 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 517418006480 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418006481 putative active site [active] 517418006482 heme pocket [chemical binding]; other site 517418006483 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 517418006484 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418006485 putative active site [active] 517418006486 heme pocket [chemical binding]; other site 517418006487 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 517418006488 dimer interface [polypeptide binding]; other site 517418006489 phosphorylation site [posttranslational modification] 517418006490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418006491 ATP binding site [chemical binding]; other site 517418006492 Mg2+ binding site [ion binding]; other site 517418006493 G-X-G motif; other site 517418006494 Response regulator receiver domain; Region: Response_reg; pfam00072 517418006495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418006496 active site 517418006497 phosphorylation site [posttranslational modification] 517418006498 intermolecular recognition site; other site 517418006499 dimerization interface [polypeptide binding]; other site 517418006500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 517418006501 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 517418006502 dimer interface [polypeptide binding]; other site 517418006503 conserved gate region; other site 517418006504 putative PBP binding loops; other site 517418006505 ABC-ATPase subunit interface; other site 517418006506 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 517418006507 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 517418006508 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 517418006509 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 517418006510 Walker A/P-loop; other site 517418006511 ATP binding site [chemical binding]; other site 517418006512 Q-loop/lid; other site 517418006513 ABC transporter signature motif; other site 517418006514 Walker B; other site 517418006515 D-loop; other site 517418006516 H-loop/switch region; other site 517418006517 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 517418006518 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 517418006519 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 517418006520 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 517418006521 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 517418006522 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 517418006523 Methyltransferase domain; Region: Methyltransf_23; pfam13489 517418006524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 517418006525 S-adenosylmethionine binding site [chemical binding]; other site 517418006526 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 517418006527 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 517418006528 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 517418006529 active site 517418006530 dimer interface [polypeptide binding]; other site 517418006531 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 517418006532 Ligand Binding Site [chemical binding]; other site 517418006533 Molecular Tunnel; other site 517418006534 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 517418006535 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 517418006536 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 517418006537 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 517418006538 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 517418006539 RNA binding site [nucleotide binding]; other site 517418006540 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 517418006541 Mechanosensitive ion channel; Region: MS_channel; pfam00924 517418006542 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 517418006543 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 517418006544 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 517418006545 ferric uptake regulator; Provisional; Region: fur; PRK09462 517418006546 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 517418006547 metal binding site 2 [ion binding]; metal-binding site 517418006548 putative DNA binding helix; other site 517418006549 metal binding site 1 [ion binding]; metal-binding site 517418006550 dimer interface [polypeptide binding]; other site 517418006551 structural Zn2+ binding site [ion binding]; other site 517418006552 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 517418006553 Peptidase family M48; Region: Peptidase_M48; cl12018 517418006554 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 517418006555 stage V sporulation protein T; Region: spore_V_T; TIGR02851 517418006556 bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566 517418006557 UbiA prenyltransferase family; Region: UbiA; pfam01040 517418006558 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 517418006559 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 517418006560 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 517418006561 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 517418006562 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 517418006563 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 517418006564 catalytic residue [active] 517418006565 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 517418006566 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 517418006567 MgtE intracellular N domain; Region: MgtE_N; smart00924 517418006568 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 517418006569 Divalent cation transporter; Region: MgtE; pfam01769 517418006570 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 517418006571 TPR motif; other site 517418006572 binding surface 517418006573 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 517418006574 TPR motif; other site 517418006575 binding surface 517418006576 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 517418006577 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 517418006578 dimer interface [polypeptide binding]; other site 517418006579 substrate binding site [chemical binding]; other site 517418006580 ATP binding site [chemical binding]; other site 517418006581 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 517418006582 thiamine phosphate binding site [chemical binding]; other site 517418006583 active site 517418006584 pyrophosphate binding site [ion binding]; other site 517418006585 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 517418006586 thiamine phosphate binding site [chemical binding]; other site 517418006587 active site 517418006588 pyrophosphate binding site [ion binding]; other site 517418006589 PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855 517418006590 putative active site [active] 517418006591 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 517418006592 ThiS interaction site; other site 517418006593 putative active site [active] 517418006594 tetramer interface [polypeptide binding]; other site 517418006595 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 517418006596 thiS-thiF/thiG interaction site; other site 517418006597 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 517418006598 hydroxyglutarate oxidase; Provisional; Region: PRK11728 517418006599 tryptophan 5-monooxygenase, tetrameric; Region: Trp_5_monoox; TIGR01270 517418006600 Cna protein B-type domain; Region: Cna_B_2; pfam13715 517418006601 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 517418006602 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 517418006603 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 517418006604 GIY-YIG motif/motif A; other site 517418006605 putative active site [active] 517418006606 putative metal binding site [ion binding]; other site 517418006607 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 517418006608 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 517418006609 catalytic triad [active] 517418006610 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 517418006611 catalytic triad [active] 517418006612 putative active site [active] 517418006613 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 517418006614 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 517418006615 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 517418006616 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 517418006617 Zn2+ binding site [ion binding]; other site 517418006618 Mg2+ binding site [ion binding]; other site 517418006619 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 517418006620 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 517418006621 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 517418006622 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 517418006623 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 517418006624 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 517418006625 protein binding site [polypeptide binding]; other site 517418006626 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 517418006627 protein binding site [polypeptide binding]; other site 517418006628 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418006629 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418006630 TPR motif; other site 517418006631 binding surface 517418006632 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418006633 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418006634 binding surface 517418006635 TPR motif; other site 517418006636 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418006637 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 517418006638 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 517418006639 metal binding site [ion binding]; metal-binding site 517418006640 active site 517418006641 I-site; other site 517418006642 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 517418006643 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 517418006644 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 517418006645 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 517418006646 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 517418006647 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 517418006648 SLBB domain; Region: SLBB; pfam10531 517418006649 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 517418006650 SLBB domain; Region: SLBB; pfam10531 517418006651 Chain length determinant protein; Region: Wzz; pfam02706 517418006652 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 517418006653 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912 517418006654 Mg++ binding site [ion binding]; other site 517418006655 putative catalytic motif [active] 517418006656 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 517418006657 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 517418006658 substrate binding site; other site 517418006659 tetramer interface; other site 517418006660 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 517418006661 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 517418006662 NADP-binding site; other site 517418006663 homotetramer interface [polypeptide binding]; other site 517418006664 substrate binding site [chemical binding]; other site 517418006665 homodimer interface [polypeptide binding]; other site 517418006666 active site 517418006667 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 517418006668 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 517418006669 NADP binding site [chemical binding]; other site 517418006670 active site 517418006671 putative substrate binding site [chemical binding]; other site 517418006672 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 517418006673 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 517418006674 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 517418006675 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 517418006676 active site 517418006677 Protein of unknown function (DUF616); Region: DUF616; pfam04765 517418006678 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 517418006679 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 517418006680 Ligand binding site; other site 517418006681 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 517418006682 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 517418006683 Probable Catalytic site; other site 517418006684 metal-binding site 517418006685 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 517418006686 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 517418006687 Walker A motif; other site 517418006688 ATP binding site [chemical binding]; other site 517418006689 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 517418006690 magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031 517418006691 Walker A motif; other site 517418006692 ATP binding site [chemical binding]; other site 517418006693 Walker B motif; other site 517418006694 arginine finger; other site 517418006695 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 517418006696 metal ion-dependent adhesion site (MIDAS); other site 517418006697 The GLUG motif; Region: Glug; pfam07581 517418006698 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 517418006699 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 517418006700 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 517418006701 Lumazine binding domain; Region: Lum_binding; pfam00677 517418006702 Lumazine binding domain; Region: Lum_binding; pfam00677 517418006703 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 517418006704 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 517418006705 catalytic motif [active] 517418006706 Zn binding site [ion binding]; other site 517418006707 RibD C-terminal domain; Region: RibD_C; cl17279 517418006708 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 517418006709 catalytic motif [active] 517418006710 Zn binding site [ion binding]; other site 517418006711 Protein of unknown function, DUF547; Region: DUF547; pfam04784 517418006712 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 517418006713 Domain of unknown function (DUF814); Region: DUF814; pfam05670 517418006714 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 517418006715 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 517418006716 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 517418006717 acyl-activating enzyme (AAE) consensus motif; other site 517418006718 putative AMP binding site [chemical binding]; other site 517418006719 putative active site [active] 517418006720 putative CoA binding site [chemical binding]; other site 517418006721 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 517418006722 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 517418006723 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 517418006724 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 517418006725 ligand binding site; other site 517418006726 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 517418006727 TPP-binding site [chemical binding]; other site 517418006728 dimer interface [polypeptide binding]; other site 517418006729 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 517418006730 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 517418006731 PYR/PP interface [polypeptide binding]; other site 517418006732 dimer interface [polypeptide binding]; other site 517418006733 TPP binding site [chemical binding]; other site 517418006734 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 517418006735 glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209 517418006736 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 517418006737 inhibitor-cofactor binding pocket; inhibition site 517418006738 pyridoxal 5'-phosphate binding site [chemical binding]; other site 517418006739 catalytic residue [active] 517418006740 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 517418006741 active site 517418006742 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 517418006743 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 517418006744 DHH family; Region: DHH; pfam01368 517418006745 DHHA1 domain; Region: DHHA1; pfam02272 517418006746 multifunctional aminopeptidase A; Provisional; Region: PRK00913 517418006747 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 517418006748 interface (dimer of trimers) [polypeptide binding]; other site 517418006749 Substrate-binding/catalytic site; other site 517418006750 Zn-binding sites [ion binding]; other site 517418006751 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 517418006752 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 517418006753 PGAP1-like protein; Region: PGAP1; pfam07819 517418006754 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 517418006755 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 517418006756 putative NAD(P) binding site [chemical binding]; other site 517418006757 active site 517418006758 phosphodiesterase; Provisional; Region: PRK12704 517418006759 Uncharacterized conserved protein [Function unknown]; Region: COG3586 517418006760 ribosomal protein L33; Region: rpl33; CHL00104 517418006761 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 517418006762 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 517418006763 active site 517418006764 catalytic residues [active] 517418006765 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 517418006766 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 517418006767 Zn binding site [ion binding]; other site 517418006768 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 517418006769 ApbE family; Region: ApbE; pfam02424 517418006770 NGN-insert domain found between N-terminal domain (D1) and C-terminal KOW domain (DIII) repeats of some N-Utilization Substance G (NusG) N-terminal (NGN); Region: NGN-insert_like; cd09910 517418006771 Protein of unknown function (DUF3570); Region: DUF3570; pfam12094 517418006772 Domain of unknown function (DUF4266); Region: DUF4266; pfam14086 517418006773 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 517418006774 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 517418006775 catalytic residues [active] 517418006776 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 517418006777 Putative zinc ribbon domain; Region: DUF164; pfam02591 517418006778 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 517418006779 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 517418006780 Walker A/P-loop; other site 517418006781 ATP binding site [chemical binding]; other site 517418006782 Q-loop/lid; other site 517418006783 ABC transporter signature motif; other site 517418006784 Walker B; other site 517418006785 D-loop; other site 517418006786 H-loop/switch region; other site 517418006787 FOG: WD40 repeat [General function prediction only]; Region: COG2319 517418006788 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 517418006789 structural tetrad; other site 517418006790 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 517418006791 B12 binding site [chemical binding]; other site 517418006792 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 517418006793 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 517418006794 FeS/SAM binding site; other site 517418006795 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 517418006796 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 517418006797 TM-ABC transporter signature motif; other site 517418006798 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 517418006799 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 517418006800 Uncharacterized conserved protein [Function unknown]; Region: COG3391 517418006801 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276 517418006802 Surface antigen; Region: Bac_surface_Ag; pfam01103 517418006803 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 517418006804 nucleoside/Zn binding site; other site 517418006805 dimer interface [polypeptide binding]; other site 517418006806 catalytic motif [active] 517418006807 Domain of unknown function (DUF955); Region: DUF955; pfam06114 517418006808 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 517418006809 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 517418006810 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 517418006811 DNA binding residues [nucleotide binding] 517418006812 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 517418006813 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 517418006814 active site 517418006815 metal binding site [ion binding]; metal-binding site 517418006816 Bacterial sugar transferase; Region: Bac_transf; cl00939 517418006817 chain length determinant protein EpsF; Region: EpsF; TIGR03017 517418006818 Chain length determinant protein; Region: Wzz; cl15801 517418006819 6-carboxyhexanoate--CoA ligase; Region: BioW; cl00625 517418006820 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 517418006821 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 517418006822 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 517418006823 P loop; other site 517418006824 Nucleotide binding site [chemical binding]; other site 517418006825 DTAP/Switch II; other site 517418006826 Switch I; other site 517418006827 colanic acid exporter; Provisional; Region: PRK10459 517418006828 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 517418006829 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 517418006830 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 517418006831 inhibitor-cofactor binding pocket; inhibition site 517418006832 pyridoxal 5'-phosphate binding site [chemical binding]; other site 517418006833 catalytic residue [active] 517418006834 ATP-grasp domain; Region: ATP-grasp_4; cl17255 517418006835 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 517418006836 extended (e) SDRs; Region: SDR_e; cd08946 517418006837 NAD(P) binding site [chemical binding]; other site 517418006838 substrate binding site [chemical binding]; other site 517418006839 active site 517418006840 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 517418006841 Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354 517418006842 Methyltransferase domain; Region: Methyltransf_23; pfam13489 517418006843 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 517418006844 S-adenosylmethionine binding site [chemical binding]; other site 517418006845 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 517418006846 4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944 517418006847 active site 517418006848 catalytic residues [active] 517418006849 metal binding site [ion binding]; metal-binding site 517418006850 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 517418006851 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 517418006852 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 517418006853 Ligand binding site; other site 517418006854 oligomer interface; other site 517418006855 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 517418006856 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 517418006857 motif II; other site 517418006858 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 517418006859 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 517418006860 active site 517418006861 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 517418006862 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 517418006863 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 517418006864 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 517418006865 putative NAD(P) binding site [chemical binding]; other site 517418006866 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 517418006867 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 517418006868 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 517418006869 putative glycosyl transferase; Provisional; Region: PRK10307 517418006870 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 517418006871 Bacterial sugar transferase; Region: Bac_transf; pfam02397 517418006872 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_4; cd08651 517418006873 putative active site [active] 517418006874 putative substrate binding site [chemical binding]; other site 517418006875 putative cosubstrate binding site; other site 517418006876 catalytic site [active] 517418006877 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 517418006878 active site 517418006879 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 517418006880 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 517418006881 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 517418006882 putative trimer interface [polypeptide binding]; other site 517418006883 putative CoA binding site [chemical binding]; other site 517418006884 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 517418006885 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 517418006886 inhibitor-cofactor binding pocket; inhibition site 517418006887 pyridoxal 5'-phosphate binding site [chemical binding]; other site 517418006888 catalytic residue [active] 517418006889 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 517418006890 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 517418006891 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 517418006892 NAD(P) binding site [chemical binding]; other site 517418006893 homodimer interface [polypeptide binding]; other site 517418006894 substrate binding site [chemical binding]; other site 517418006895 active site 517418006896 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 517418006897 acetyl-CoA synthetase; Provisional; Region: PRK00174 517418006898 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 517418006899 acyl-activating enzyme (AAE) consensus motif; other site 517418006900 AMP binding site [chemical binding]; other site 517418006901 active site 517418006902 CoA binding site [chemical binding]; other site 517418006903 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 517418006904 FMN binding site [chemical binding]; other site 517418006905 substrate binding site [chemical binding]; other site 517418006906 putative catalytic residue [active] 517418006907 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 517418006908 catalytic core [active] 517418006909 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 517418006910 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 517418006911 substrate binding pocket [chemical binding]; other site 517418006912 Ion channel; Region: Ion_trans_2; pfam07885 517418006913 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 517418006914 membrane-bound complex binding site; other site 517418006915 hinge residues; other site 517418006916 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 517418006917 tartrate dehydrogenase; Region: TTC; TIGR02089 517418006918 PBP superfamily domain; Region: PBP_like_2; cl17296 517418006919 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258 517418006920 active site 517418006921 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 517418006922 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 517418006923 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 517418006924 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 517418006925 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 517418006926 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 517418006927 active site 517418006928 dimer interface [polypeptide binding]; other site 517418006929 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 517418006930 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 517418006931 active site 517418006932 FMN binding site [chemical binding]; other site 517418006933 substrate binding site [chemical binding]; other site 517418006934 3Fe-4S cluster binding site [ion binding]; other site 517418006935 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 517418006936 domain interface; other site 517418006937 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 517418006938 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 517418006939 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 517418006940 Transglycosylase; Region: Transgly; pfam00912 517418006941 Permease; Region: Permease; pfam02405 517418006942 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 517418006943 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 517418006944 Walker A/P-loop; other site 517418006945 ATP binding site [chemical binding]; other site 517418006946 Q-loop/lid; other site 517418006947 ABC transporter signature motif; other site 517418006948 Walker B; other site 517418006949 D-loop; other site 517418006950 H-loop/switch region; other site 517418006951 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 517418006952 mce related protein; Region: MCE; pfam02470 517418006953 Tetratricopeptide repeat; Region: TPR_12; pfam13424 517418006954 PBP superfamily domain; Region: PBP_like_2; pfam12849 517418006955 PBP superfamily domain; Region: PBP_like_2; pfam12849 517418006956 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 517418006957 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 517418006958 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 517418006959 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 517418006960 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 517418006961 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 517418006962 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 517418006963 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 517418006964 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 517418006965 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 517418006966 PAS domain S-box; Region: sensory_box; TIGR00229 517418006967 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418006968 putative active site [active] 517418006969 heme pocket [chemical binding]; other site 517418006970 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 517418006971 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418006972 putative active site [active] 517418006973 heme pocket [chemical binding]; other site 517418006974 PAS domain S-box; Region: sensory_box; TIGR00229 517418006975 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418006976 putative active site [active] 517418006977 heme pocket [chemical binding]; other site 517418006978 PAS domain S-box; Region: sensory_box; TIGR00229 517418006979 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418006980 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 517418006981 putative active site [active] 517418006982 heme pocket [chemical binding]; other site 517418006983 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418006984 putative active site [active] 517418006985 heme pocket [chemical binding]; other site 517418006986 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 517418006987 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418006988 putative active site [active] 517418006989 heme pocket [chemical binding]; other site 517418006990 PAS domain S-box; Region: sensory_box; TIGR00229 517418006991 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418006992 putative active site [active] 517418006993 heme pocket [chemical binding]; other site 517418006994 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 517418006995 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418006996 putative active site [active] 517418006997 heme pocket [chemical binding]; other site 517418006998 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418006999 putative active site [active] 517418007000 heme pocket [chemical binding]; other site 517418007001 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 517418007002 dimer interface [polypeptide binding]; other site 517418007003 phosphorylation site [posttranslational modification] 517418007004 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418007005 ATP binding site [chemical binding]; other site 517418007006 Mg2+ binding site [ion binding]; other site 517418007007 G-X-G motif; other site 517418007008 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 517418007009 BCCT family transporter; Region: BCCT; pfam02028 517418007010 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 517418007011 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 517418007012 S-adenosylmethionine binding site [chemical binding]; other site 517418007013 Methyltransferase domain; Region: Methyltransf_31; pfam13847 517418007014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 517418007015 S-adenosylmethionine binding site [chemical binding]; other site 517418007016 HAMP domain; Region: HAMP; pfam00672 517418007017 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 517418007018 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 517418007019 metal binding site [ion binding]; metal-binding site 517418007020 active site 517418007021 I-site; other site 517418007022 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 517418007023 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 517418007024 FtsX-like permease family; Region: FtsX; pfam02687 517418007025 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 517418007026 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 517418007027 FtsX-like permease family; Region: FtsX; pfam02687 517418007028 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 517418007029 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 517418007030 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 517418007031 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 517418007032 ligand binding site [chemical binding]; other site 517418007033 flexible hinge region; other site 517418007034 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 517418007035 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 517418007036 catalytic loop [active] 517418007037 iron binding site [ion binding]; other site 517418007038 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 517418007039 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 517418007040 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 517418007041 helix-hairpin-helix signature motif; other site 517418007042 substrate binding pocket [chemical binding]; other site 517418007043 active site 517418007044 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 517418007045 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 517418007046 minor groove reading motif; other site 517418007047 helix-hairpin-helix signature motif; other site 517418007048 substrate binding pocket [chemical binding]; other site 517418007049 active site 517418007050 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 517418007051 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 517418007052 active site 517418007053 8-oxo-dGMP binding site [chemical binding]; other site 517418007054 nudix motif; other site 517418007055 metal binding site [ion binding]; metal-binding site 517418007056 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 517418007057 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 517418007058 motif II; other site 517418007059 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 517418007060 NADH(P)-binding; Region: NAD_binding_10; pfam13460 517418007061 NAD(P) binding site [chemical binding]; other site 517418007062 putative active site [active] 517418007063 lipoyl synthase; Provisional; Region: PRK05481 517418007064 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 517418007065 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 517418007066 E3 interaction surface; other site 517418007067 lipoyl attachment site [posttranslational modification]; other site 517418007068 e3 binding domain; Region: E3_binding; pfam02817 517418007069 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 517418007070 Protein of unknown function (DUF419); Region: DUF419; pfam04237 517418007071 Domain of unknown function (DUF4404); Region: DUF4404; pfam14357 517418007072 Methyltransferase domain; Region: Methyltransf_23; pfam13489 517418007073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 517418007074 S-adenosylmethionine binding site [chemical binding]; other site 517418007075 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 517418007076 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 517418007077 catalytic residues [active] 517418007078 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 517418007079 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 517418007080 active site 517418007081 DNA binding site [nucleotide binding] 517418007082 Int/Topo IB signature motif; other site 517418007083 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 517418007084 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 517418007085 N-terminal plug; other site 517418007086 ligand-binding site [chemical binding]; other site 517418007087 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 517418007088 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 517418007089 FG-GAP repeat; Region: FG-GAP_2; pfam14312 517418007090 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 517418007091 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 517418007092 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 517418007093 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 517418007094 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 517418007095 active site 517418007096 SAM binding site [chemical binding]; other site 517418007097 homodimer interface [polypeptide binding]; other site 517418007098 TIR domain; Region: TIR_2; pfam13676 517418007099 FOG: WD40 repeat [General function prediction only]; Region: COG2319 517418007100 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 517418007101 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 517418007102 structural tetrad; other site 517418007103 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 517418007104 active site 517418007105 putative homodimer interface [polypeptide binding]; other site 517418007106 SAM binding site [chemical binding]; other site 517418007107 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 517418007108 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 517418007109 S-adenosylmethionine binding site [chemical binding]; other site 517418007110 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 517418007111 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 517418007112 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 517418007113 active site 517418007114 SAM binding site [chemical binding]; other site 517418007115 homodimer interface [polypeptide binding]; other site 517418007116 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 517418007117 Precorrin-8X methylmutase; Region: CbiC; pfam02570 517418007118 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 517418007119 active site 517418007120 SAM binding site [chemical binding]; other site 517418007121 homodimer interface [polypeptide binding]; other site 517418007122 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 517418007123 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 517418007124 putative active site [active] 517418007125 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 517418007126 putative active site [active] 517418007127 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 517418007128 active site 517418007129 SAM binding site [chemical binding]; other site 517418007130 homodimer interface [polypeptide binding]; other site 517418007131 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 517418007132 putative FMN binding site [chemical binding]; other site 517418007133 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 517418007134 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 517418007135 NAD(P) binding site [chemical binding]; other site 517418007136 active site 517418007137 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13636 517418007138 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 517418007139 Walker A/P-loop; other site 517418007140 ATP binding site [chemical binding]; other site 517418007141 Q-loop/lid; other site 517418007142 ABC transporter signature motif; other site 517418007143 Walker B; other site 517418007144 D-loop; other site 517418007145 H-loop/switch region; other site 517418007146 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 517418007147 cobalt transport protein CbiN; Provisional; Region: PRK02898 517418007148 cobalt transport protein CbiM; Validated; Region: PRK08319 517418007149 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 517418007150 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 517418007151 Predicted amidohydrolase [General function prediction only]; Region: COG0388 517418007152 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 517418007153 active site 517418007154 catalytic triad [active] 517418007155 dimer interface [polypeptide binding]; other site 517418007156 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 517418007157 dimer interface [polypeptide binding]; other site 517418007158 active site 517418007159 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 517418007160 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 517418007161 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 517418007162 putative ligand binding site [chemical binding]; other site 517418007163 Sensory domain found in PocR; Region: PocR; pfam10114 517418007164 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 517418007165 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418007166 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 517418007167 putative active site [active] 517418007168 heme pocket [chemical binding]; other site 517418007169 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418007170 putative active site [active] 517418007171 heme pocket [chemical binding]; other site 517418007172 PAS fold; Region: PAS_4; pfam08448 517418007173 PAS domain S-box; Region: sensory_box; TIGR00229 517418007174 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418007175 putative active site [active] 517418007176 heme pocket [chemical binding]; other site 517418007177 PAS domain S-box; Region: sensory_box; TIGR00229 517418007178 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418007179 putative active site [active] 517418007180 heme pocket [chemical binding]; other site 517418007181 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 517418007182 dimer interface [polypeptide binding]; other site 517418007183 phosphorylation site [posttranslational modification] 517418007184 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418007185 ATP binding site [chemical binding]; other site 517418007186 Mg2+ binding site [ion binding]; other site 517418007187 G-X-G motif; other site 517418007188 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 517418007189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418007190 active site 517418007191 phosphorylation site [posttranslational modification] 517418007192 intermolecular recognition site; other site 517418007193 dimerization interface [polypeptide binding]; other site 517418007194 DNA primase; Validated; Region: dnaG; PRK05667 517418007195 CHC2 zinc finger; Region: zf-CHC2; pfam01807 517418007196 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 517418007197 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 517418007198 active site 517418007199 metal binding site [ion binding]; metal-binding site 517418007200 interdomain interaction site; other site 517418007201 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 517418007202 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 517418007203 Peptidase family M23; Region: Peptidase_M23; pfam01551 517418007204 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 517418007205 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 517418007206 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 517418007207 Double zinc ribbon; Region: DZR; pfam12773 517418007208 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 517418007209 DNA methylase; Region: N6_N4_Mtase; pfam01555 517418007210 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 517418007211 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 517418007212 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418007213 active site 517418007214 phosphorylation site [posttranslational modification] 517418007215 intermolecular recognition site; other site 517418007216 dimerization interface [polypeptide binding]; other site 517418007217 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 517418007218 DNA binding site [nucleotide binding] 517418007219 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 517418007220 dimerization interface [polypeptide binding]; other site 517418007221 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 517418007222 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 517418007223 dimer interface [polypeptide binding]; other site 517418007224 phosphorylation site [posttranslational modification] 517418007225 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418007226 ATP binding site [chemical binding]; other site 517418007227 Mg2+ binding site [ion binding]; other site 517418007228 G-X-G motif; other site 517418007229 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 517418007230 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 517418007231 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 517418007232 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 517418007233 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 517418007234 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 517418007235 active site residue [active] 517418007236 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 517418007237 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 517418007238 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 517418007239 putative active site [active] 517418007240 putative metal binding site [ion binding]; other site 517418007241 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 517418007242 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 517418007243 Cl- selectivity filter; other site 517418007244 Cl- binding residues [ion binding]; other site 517418007245 pore gating glutamate residue; other site 517418007246 dimer interface [polypeptide binding]; other site 517418007247 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 517418007248 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 517418007249 CoenzymeA binding site [chemical binding]; other site 517418007250 subunit interaction site [polypeptide binding]; other site 517418007251 PHB binding site; other site 517418007252 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 517418007253 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 517418007254 acyl-activating enzyme (AAE) consensus motif; other site 517418007255 putative AMP binding site [chemical binding]; other site 517418007256 putative active site [active] 517418007257 putative CoA binding site [chemical binding]; other site 517418007258 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 517418007259 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 517418007260 N-terminal plug; other site 517418007261 ligand-binding site [chemical binding]; other site 517418007262 Cytochrome c; Region: Cytochrom_C; pfam00034 517418007263 Surface antigen; Region: Bac_surface_Ag; pfam01103 517418007264 von Willebrand factor type A domain; Region: VWA_2; pfam13519 517418007265 metal ion-dependent adhesion site (MIDAS); other site 517418007266 Lamin Tail Domain; Region: LTD; pfam00932 517418007267 Lamin Tail Domain; Region: LTD; pfam00932 517418007268 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 517418007269 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 517418007270 GAF domain; Region: GAF_2; pfam13185 517418007271 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 517418007272 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 517418007273 dimer interface [polypeptide binding]; other site 517418007274 decamer (pentamer of dimers) interface [polypeptide binding]; other site 517418007275 catalytic triad [active] 517418007276 peroxidatic and resolving cysteines [active] 517418007277 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 517418007278 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 517418007279 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 517418007280 DHH family; Region: DHH; pfam01368 517418007281 DHHA1 domain; Region: DHHA1; pfam02272 517418007282 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 517418007283 AMP binding site [chemical binding]; other site 517418007284 metal binding site [ion binding]; metal-binding site 517418007285 active site 517418007286 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 517418007287 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 517418007288 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 517418007289 CoA-ligase; Region: Ligase_CoA; pfam00549 517418007290 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 517418007291 carboxy-terminal protease; Provisional; Region: PRK11186 517418007292 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 517418007293 protein binding site [polypeptide binding]; other site 517418007294 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 517418007295 Catalytic dyad [active] 517418007296 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 517418007297 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 517418007298 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 517418007299 ligand binding site [chemical binding]; other site 517418007300 flexible hinge region; other site 517418007301 LPP20 lipoprotein; Region: LPP20; pfam02169 517418007302 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 517418007303 PEGA domain; Region: PEGA; pfam08308 517418007304 PEGA domain; Region: PEGA; pfam08308 517418007305 PEGA domain; Region: PEGA; pfam08308 517418007306 PEGA domain; Region: PEGA; pfam08308 517418007307 NifZ domain; Region: NifZ; pfam04319 517418007308 NifZ domain; Region: NifZ; pfam04319 517418007309 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 517418007310 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 517418007311 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 517418007312 heterotetramer interface [polypeptide binding]; other site 517418007313 active site pocket [active] 517418007314 cleavage site 517418007315 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 517418007316 feedback inhibition sensing region; other site 517418007317 homohexameric interface [polypeptide binding]; other site 517418007318 nucleotide binding site [chemical binding]; other site 517418007319 N-acetyl-L-glutamate binding site [chemical binding]; other site 517418007320 ornithine carbamoyltransferase; Provisional; Region: PRK00779 517418007321 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 517418007322 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 517418007323 Arginine repressor [Transcription]; Region: ArgR; COG1438 517418007324 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 517418007325 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 517418007326 argininosuccinate synthase; Provisional; Region: PRK13820 517418007327 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 517418007328 ANP binding site [chemical binding]; other site 517418007329 Substrate Binding Site II [chemical binding]; other site 517418007330 Substrate Binding Site I [chemical binding]; other site 517418007331 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 517418007332 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 517418007333 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 517418007334 trimer interface [polypeptide binding]; other site 517418007335 active site 517418007336 UDP-GlcNAc binding site [chemical binding]; other site 517418007337 lipid binding site [chemical binding]; lipid-binding site 517418007338 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 517418007339 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 517418007340 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 517418007341 active site 517418007342 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 517418007343 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 517418007344 5S rRNA interface [nucleotide binding]; other site 517418007345 CTC domain interface [polypeptide binding]; other site 517418007346 L16 interface [polypeptide binding]; other site 517418007347 Response regulator receiver domain; Region: Response_reg; pfam00072 517418007348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418007349 active site 517418007350 phosphorylation site [posttranslational modification] 517418007351 intermolecular recognition site; other site 517418007352 dimerization interface [polypeptide binding]; other site 517418007353 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 517418007354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 517418007355 dimer interface [polypeptide binding]; other site 517418007356 conserved gate region; other site 517418007357 putative PBP binding loops; other site 517418007358 ABC-ATPase subunit interface; other site 517418007359 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 517418007360 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 517418007361 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 517418007362 tRNA; other site 517418007363 putative tRNA binding site [nucleotide binding]; other site 517418007364 putative NADP binding site [chemical binding]; other site 517418007365 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 517418007366 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 517418007367 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 517418007368 domain interfaces; other site 517418007369 active site 517418007370 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 517418007371 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 517418007372 active site 517418007373 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 517418007374 active site 517418007375 nucleophile elbow; other site 517418007376 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 517418007377 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 517418007378 Transposase [DNA replication, recombination, and repair]; Region: COG5433 517418007379 Transposase [DNA replication, recombination, and repair]; Region: COG5433 517418007380 Methyltransferase domain; Region: Methyltransf_31; pfam13847 517418007381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 517418007382 S-adenosylmethionine binding site [chemical binding]; other site 517418007383 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 517418007384 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 517418007385 active site 517418007386 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 517418007387 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 517418007388 tetramer interface [polypeptide binding]; other site 517418007389 TPP-binding site [chemical binding]; other site 517418007390 heterodimer interface [polypeptide binding]; other site 517418007391 phosphorylation loop region [posttranslational modification] 517418007392 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 517418007393 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 517418007394 PYR/PP interface [polypeptide binding]; other site 517418007395 dimer interface [polypeptide binding]; other site 517418007396 TPP binding site [chemical binding]; other site 517418007397 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 517418007398 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 517418007399 dimer interface [polypeptide binding]; other site 517418007400 allosteric magnesium binding site [ion binding]; other site 517418007401 active site 517418007402 aspartate-rich active site metal binding site; other site 517418007403 Schiff base residues; other site 517418007404 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 517418007405 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 517418007406 Tetramer interface [polypeptide binding]; other site 517418007407 active site 517418007408 FMN-binding site [chemical binding]; other site 517418007409 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 517418007410 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 517418007411 SmpB-tmRNA interface; other site 517418007412 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 517418007413 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 517418007414 active site 517418007415 HIGH motif; other site 517418007416 dimer interface [polypeptide binding]; other site 517418007417 KMSKS motif; other site 517418007418 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 517418007419 RNA binding surface [nucleotide binding]; other site 517418007420 pyruvoyl-dependent arginine decarboxylase; Reviewed; Region: PRK01285 517418007421 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 517418007422 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 517418007423 B12 binding site [chemical binding]; other site 517418007424 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 517418007425 FeS/SAM binding site; other site 517418007426 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 517418007427 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 517418007428 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 517418007429 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 517418007430 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 517418007431 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 517418007432 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 517418007433 Walker A motif; other site 517418007434 ATP binding site [chemical binding]; other site 517418007435 Walker B motif; other site 517418007436 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 517418007437 PAS domain S-box; Region: sensory_box; TIGR00229 517418007438 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418007439 putative active site [active] 517418007440 heme pocket [chemical binding]; other site 517418007441 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418007442 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 517418007443 putative active site [active] 517418007444 heme pocket [chemical binding]; other site 517418007445 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418007446 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 517418007447 putative active site [active] 517418007448 heme pocket [chemical binding]; other site 517418007449 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418007450 PAS domain; Region: PAS_9; pfam13426 517418007451 putative active site [active] 517418007452 heme pocket [chemical binding]; other site 517418007453 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418007454 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 517418007455 putative active site [active] 517418007456 heme pocket [chemical binding]; other site 517418007457 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418007458 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 517418007459 putative active site [active] 517418007460 heme pocket [chemical binding]; other site 517418007461 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418007462 putative active site [active] 517418007463 heme pocket [chemical binding]; other site 517418007464 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 517418007465 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418007466 putative active site [active] 517418007467 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 517418007468 dimer interface [polypeptide binding]; other site 517418007469 phosphorylation site [posttranslational modification] 517418007470 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418007471 ATP binding site [chemical binding]; other site 517418007472 Mg2+ binding site [ion binding]; other site 517418007473 G-X-G motif; other site 517418007474 Response regulator receiver domain; Region: Response_reg; pfam00072 517418007475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418007476 active site 517418007477 phosphorylation site [posttranslational modification] 517418007478 intermolecular recognition site; other site 517418007479 dimerization interface [polypeptide binding]; other site 517418007480 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418007481 binding surface 517418007482 TPR motif; other site 517418007483 TPR repeat; Region: TPR_11; pfam13414 517418007484 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418007485 binding surface 517418007486 TPR motif; other site 517418007487 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418007488 binding surface 517418007489 TPR repeat; Region: TPR_11; pfam13414 517418007490 TPR motif; other site 517418007491 TPR repeat; Region: TPR_11; pfam13414 517418007492 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418007493 binding surface 517418007494 TPR motif; other site 517418007495 TPR repeat; Region: TPR_11; pfam13414 517418007496 Tetratricopeptide repeat; Region: TPR_16; pfam13432 517418007497 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 517418007498 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 517418007499 putative ligand binding site [chemical binding]; other site 517418007500 putative NAD binding site [chemical binding]; other site 517418007501 catalytic site [active] 517418007502 thymidine kinase; Provisional; Region: PRK04296 517418007503 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 517418007504 active site 517418007505 catalytic motif [active] 517418007506 Zn binding site [ion binding]; other site 517418007507 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 517418007508 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 517418007509 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 517418007510 active site 517418007511 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 517418007512 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 517418007513 NAD(P) binding site [chemical binding]; other site 517418007514 catalytic residues [active] 517418007515 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 517418007516 Low molecular weight phosphatase family; Region: LMWPc; cd00115 517418007517 active site 517418007518 Fructosamine kinase; Region: Fructosamin_kin; cl17579 517418007519 Phosphotransferase enzyme family; Region: APH; pfam01636 517418007520 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 517418007521 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 517418007522 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 517418007523 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 517418007524 Cu(I) binding site [ion binding]; other site 517418007525 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 517418007526 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 517418007527 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 517418007528 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 517418007529 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 517418007530 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 517418007531 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 517418007532 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 517418007533 Ferrochelatase; Region: Ferrochelatase; pfam00762 517418007534 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 517418007535 active site 517418007536 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 517418007537 active site 517418007538 N-terminal domain interface [polypeptide binding]; other site 517418007539 PEGA domain; Region: PEGA; pfam08308 517418007540 PEGA domain; Region: PEGA; pfam08308 517418007541 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 517418007542 Uncharacterized conserved protein [Function unknown]; Region: COG1262 517418007543 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 517418007544 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 517418007545 The C-terminal domain of uncharacterized bacterial proteins; Region: Bvu_2165_C_like; cd12843 517418007546 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 517418007547 nucleotide binding site [chemical binding]; other site 517418007548 Uncharacterized conserved protein [Function unknown]; Region: COG1262 517418007549 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 517418007550 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 517418007551 GTP/Mg2+ binding site [chemical binding]; other site 517418007552 G5 box; other site 517418007553 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 517418007554 G1 box; other site 517418007555 G1 box; other site 517418007556 GTP/Mg2+ binding site [chemical binding]; other site 517418007557 G2 box; other site 517418007558 Switch I region; other site 517418007559 G3 box; other site 517418007560 Switch II region; other site 517418007561 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 517418007562 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 517418007563 nucleotide binding site [chemical binding]; other site 517418007564 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 517418007565 Dynamin family; Region: Dynamin_N; pfam00350 517418007566 G1 box; other site 517418007567 GTP/Mg2+ binding site [chemical binding]; other site 517418007568 G2 box; other site 517418007569 Switch I region; other site 517418007570 G3 box; other site 517418007571 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 517418007572 G3 box; other site 517418007573 Switch II region; other site 517418007574 GTP/Mg2+ binding site [chemical binding]; other site 517418007575 G4 box; other site 517418007576 G5 box; other site 517418007577 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 517418007578 putative active site [active] 517418007579 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 517418007580 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 517418007581 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 517418007582 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 517418007583 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 517418007584 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 517418007585 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 517418007586 protein binding site [polypeptide binding]; other site 517418007587 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 517418007588 Catalytic dyad [active] 517418007589 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 517418007590 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 517418007591 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 517418007592 dimerization interface [polypeptide binding]; other site 517418007593 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 517418007594 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 517418007595 dimer interface [polypeptide binding]; other site 517418007596 putative CheW interface [polypeptide binding]; other site 517418007597 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 517418007598 putative binding surface; other site 517418007599 active site 517418007600 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 517418007601 putative binding surface; other site 517418007602 active site 517418007603 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 517418007604 putative binding surface; other site 517418007605 active site 517418007606 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 517418007607 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 517418007608 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418007609 ATP binding site [chemical binding]; other site 517418007610 Mg2+ binding site [ion binding]; other site 517418007611 G-X-G motif; other site 517418007612 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 517418007613 Response regulator receiver domain; Region: Response_reg; pfam00072 517418007614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418007615 active site 517418007616 phosphorylation site [posttranslational modification] 517418007617 intermolecular recognition site; other site 517418007618 dimerization interface [polypeptide binding]; other site 517418007619 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 517418007620 CheW-like domain; Region: CheW; pfam01584 517418007621 Response regulator receiver domain; Region: Response_reg; pfam00072 517418007622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418007623 active site 517418007624 phosphorylation site [posttranslational modification] 517418007625 intermolecular recognition site; other site 517418007626 dimerization interface [polypeptide binding]; other site 517418007627 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 517418007628 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 517418007629 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 517418007630 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 517418007631 G1 box; other site 517418007632 GTP/Mg2+ binding site [chemical binding]; other site 517418007633 G2 box; other site 517418007634 Switch I region; other site 517418007635 G3 box; other site 517418007636 Switch II region; other site 517418007637 G4 box; other site 517418007638 G5 box; other site 517418007639 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 517418007640 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 517418007641 putative active site; other site 517418007642 catalytic residue [active] 517418007643 Sensors of blue-light using FAD; Region: BLUF; pfam04940 517418007644 circadian clock protein KaiC; Reviewed; Region: PRK09302 517418007645 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 517418007646 Walker A motif; other site 517418007647 ATP binding site [chemical binding]; other site 517418007648 Walker B motif; other site 517418007649 recA bacterial DNA recombination protein; Region: RecA; cl17211 517418007650 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 517418007651 Walker A motif; other site 517418007652 ATP binding site [chemical binding]; other site 517418007653 Walker B motif; other site 517418007654 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 517418007655 tetramer interface [polypeptide binding]; other site 517418007656 dimer interface [polypeptide binding]; other site 517418007657 GAF domain; Region: GAF_2; pfam13185 517418007658 GAF domain; Region: GAF; pfam01590 517418007659 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 517418007660 PEGA domain; Region: PEGA; pfam08308 517418007661 Haemolysin-III related; Region: HlyIII; cl03831 517418007662 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 517418007663 Lamin Tail Domain; Region: LTD; pfam00932 517418007664 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 517418007665 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 517418007666 dephospho-CoA kinase; Provisional; Region: coaE; PRK14731 517418007667 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 517418007668 CoA-binding site [chemical binding]; other site 517418007669 ATP-binding [chemical binding]; other site 517418007670 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 517418007671 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 517418007672 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 517418007673 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 517418007674 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 517418007675 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 517418007676 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 517418007677 putative RNA binding site [nucleotide binding]; other site 517418007678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 517418007679 S-adenosylmethionine binding site [chemical binding]; other site 517418007680 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 517418007681 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 517418007682 dimer interface [polypeptide binding]; other site 517418007683 NAD binding site [chemical binding]; other site 517418007684 substrate binding site [chemical binding]; other site 517418007685 tetramer (dimer of dimers) interface [polypeptide binding]; other site 517418007686 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 517418007687 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 517418007688 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 517418007689 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 517418007690 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 517418007691 LytTr DNA-binding domain; Region: LytTR; smart00850 517418007692 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 517418007693 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 517418007694 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 517418007695 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 517418007696 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 517418007697 active site 517418007698 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 517418007699 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 517418007700 Uncharacterized conserved protein [Function unknown]; Region: COG2308 517418007701 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 517418007702 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 517418007703 substrate binding pocket [chemical binding]; other site 517418007704 chain length determination region; other site 517418007705 substrate-Mg2+ binding site; other site 517418007706 catalytic residues [active] 517418007707 aspartate-rich region 1; other site 517418007708 active site lid residues [active] 517418007709 aspartate-rich region 2; other site 517418007710 Putative molybdenum carrier; Region: MoCo_carrier; pfam12694 517418007711 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 517418007712 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 517418007713 FeS/SAM binding site; other site 517418007714 Response regulator receiver domain; Region: Response_reg; pfam00072 517418007715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418007716 active site 517418007717 phosphorylation site [posttranslational modification] 517418007718 intermolecular recognition site; other site 517418007719 dimerization interface [polypeptide binding]; other site 517418007720 ZIP Zinc transporter; Region: Zip; pfam02535 517418007721 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 517418007722 LPP20 lipoprotein; Region: LPP20; pfam02169 517418007723 LPP20 lipoprotein; Region: LPP20; cl15824 517418007724 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 517418007725 ThiC-associated domain; Region: ThiC-associated; pfam13667 517418007726 ThiC family; Region: ThiC; pfam01964 517418007727 PUCC protein; Region: PUCC; pfam03209 517418007728 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 517418007729 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 517418007730 [2Fe-2S] cluster binding site [ion binding]; other site 517418007731 iron-sulfur cluster [ion binding]; other site 517418007732 Polymerase and Histidinol Phosphatase domain of Thermotoga like; Region: PHP_HisPPase_Thermotoga_like; cd12111 517418007733 PHP domain; Region: PHP; pfam02811 517418007734 active site 517418007735 dimer interface [polypeptide binding]; other site 517418007736 Predicted esterase [General function prediction only]; Region: COG0400 517418007737 putative hydrolase; Provisional; Region: PRK11460 517418007738 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 517418007739 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 517418007740 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 517418007741 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 517418007742 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 517418007743 4Fe-4S single cluster domain; Region: Fer4_14; pfam13394 517418007744 FeS/SAM binding site; other site 517418007745 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 517418007746 Protein of unknown function (DUF3299); Region: DUF3299; cl01387 517418007747 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 517418007748 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 517418007749 FtsX-like permease family; Region: FtsX; pfam02687 517418007750 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 517418007751 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 517418007752 Walker A/P-loop; other site 517418007753 ATP binding site [chemical binding]; other site 517418007754 Q-loop/lid; other site 517418007755 ABC transporter signature motif; other site 517418007756 Walker B; other site 517418007757 D-loop; other site 517418007758 H-loop/switch region; other site 517418007759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 517418007760 S-adenosylmethionine binding site [chemical binding]; other site 517418007761 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 517418007762 DNA photolyase; Region: DNA_photolyase; pfam00875 517418007763 Response regulator receiver domain; Region: Response_reg; pfam00072 517418007764 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418007765 active site 517418007766 phosphorylation site [posttranslational modification] 517418007767 intermolecular recognition site; other site 517418007768 dimerization interface [polypeptide binding]; other site 517418007769 PAS domain S-box; Region: sensory_box; TIGR00229 517418007770 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418007771 putative active site [active] 517418007772 heme pocket [chemical binding]; other site 517418007773 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 517418007774 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418007775 ATP binding site [chemical binding]; other site 517418007776 Mg2+ binding site [ion binding]; other site 517418007777 G-X-G motif; other site 517418007778 Response regulator receiver domain; Region: Response_reg; pfam00072 517418007779 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418007780 active site 517418007781 phosphorylation site [posttranslational modification] 517418007782 intermolecular recognition site; other site 517418007783 dimerization interface [polypeptide binding]; other site 517418007784 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 517418007785 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 517418007786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 517418007787 dimer interface [polypeptide binding]; other site 517418007788 conserved gate region; other site 517418007789 putative PBP binding loops; other site 517418007790 ABC-ATPase subunit interface; other site 517418007791 rod shape-determining protein MreC; Provisional; Region: PRK13922 517418007792 rod shape-determining protein MreC; Region: MreC; pfam04085 517418007793 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 517418007794 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 517418007795 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 517418007796 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 517418007797 FAD binding domain; Region: FAD_binding_4; pfam01565 517418007798 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 517418007799 Alpha amylase catalytic domain found in archaeal, bacterial, and plant Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_plant_AmyA; cd11314 517418007800 active site 517418007801 Ca binding site [ion binding]; other site 517418007802 catalytic site [active] 517418007803 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 517418007804 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 517418007805 ligand binding site [chemical binding]; other site 517418007806 flexible hinge region; other site 517418007807 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 517418007808 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 517418007809 NAD(P) binding site [chemical binding]; other site 517418007810 putative active site [active] 517418007811 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 517418007812 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 517418007813 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 517418007814 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 517418007815 protein binding site [polypeptide binding]; other site 517418007816 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 517418007817 active site 517418007818 Predicted integral membrane protein [Function unknown]; Region: COG5652 517418007819 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 517418007820 Peptidase family M23; Region: Peptidase_M23; pfam01551 517418007821 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 517418007822 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 517418007823 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 517418007824 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 517418007825 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 517418007826 hinge; other site 517418007827 active site 517418007828 Cna protein B-type domain; Region: Cna_B; pfam05738 517418007829 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 517418007830 Protein of unknown function DUF58; Region: DUF58; pfam01882 517418007831 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 517418007832 metal ion-dependent adhesion site (MIDAS); other site 517418007833 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 517418007834 metal binding site 2 [ion binding]; metal-binding site 517418007835 putative DNA binding helix; other site 517418007836 metal binding site 1 [ion binding]; metal-binding site 517418007837 dimer interface [polypeptide binding]; other site 517418007838 structural Zn2+ binding site [ion binding]; other site 517418007839 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 517418007840 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 517418007841 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 517418007842 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 517418007843 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 517418007844 Walker A motif; other site 517418007845 ATP binding site [chemical binding]; other site 517418007846 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 517418007847 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 517418007848 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 517418007849 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 517418007850 metal ion-dependent adhesion site (MIDAS); other site 517418007851 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 517418007852 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 517418007853 N-terminal plug; other site 517418007854 ligand-binding site [chemical binding]; other site 517418007855 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 517418007856 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 517418007857 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 517418007858 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 517418007859 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 517418007860 FeS/SAM binding site; other site 517418007861 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 517418007862 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 517418007863 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 517418007864 intersubunit interface [polypeptide binding]; other site 517418007865 Cna protein B-type domain; Region: Cna_B_2; pfam13715 517418007866 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 517418007867 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 517418007868 N-terminal plug; other site 517418007869 ligand-binding site [chemical binding]; other site 517418007870 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 517418007871 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 517418007872 Walker A/P-loop; other site 517418007873 ATP binding site [chemical binding]; other site 517418007874 Q-loop/lid; other site 517418007875 ABC transporter signature motif; other site 517418007876 Walker B; other site 517418007877 D-loop; other site 517418007878 H-loop/switch region; other site 517418007879 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 517418007880 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 517418007881 ABC-ATPase subunit interface; other site 517418007882 dimer interface [polypeptide binding]; other site 517418007883 putative PBP binding regions; other site 517418007884 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 517418007885 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 517418007886 putative ligand binding site [chemical binding]; other site 517418007887 argininosuccinate lyase; Provisional; Region: PRK00855 517418007888 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 517418007889 active sites [active] 517418007890 tetramer interface [polypeptide binding]; other site 517418007891 aconitate hydratase, mitochondrial; Region: aconitase_mito; TIGR01340 517418007892 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Mitochondrial; cd01584 517418007893 substrate binding site [chemical binding]; other site 517418007894 ligand binding site [chemical binding]; other site 517418007895 Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes...; Region: AcnA_Mitochon_Swivel; cd01578 517418007896 substrate binding site [chemical binding]; other site 517418007897 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 517418007898 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 517418007899 dimerization interface [polypeptide binding]; other site 517418007900 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 517418007901 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 517418007902 dimer interface [polypeptide binding]; other site 517418007903 putative CheW interface [polypeptide binding]; other site 517418007904 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 517418007905 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 517418007906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418007907 active site 517418007908 phosphorylation site [posttranslational modification] 517418007909 intermolecular recognition site; other site 517418007910 dimerization interface [polypeptide binding]; other site 517418007911 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 517418007912 Response regulator receiver domain; Region: Response_reg; pfam00072 517418007913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418007914 active site 517418007915 phosphorylation site [posttranslational modification] 517418007916 intermolecular recognition site; other site 517418007917 dimerization interface [polypeptide binding]; other site 517418007918 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 517418007919 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 517418007920 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 517418007921 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 517418007922 RimM N-terminal domain; Region: RimM; pfam01782 517418007923 PRC-barrel domain; Region: PRC; pfam05239 517418007924 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 517418007925 signal recognition particle protein; Provisional; Region: PRK10867 517418007926 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 517418007927 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 517418007928 P loop; other site 517418007929 GTP binding site [chemical binding]; other site 517418007930 Signal peptide binding domain; Region: SRP_SPB; pfam02978 517418007931 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 517418007932 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 517418007933 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 517418007934 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 517418007935 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 517418007936 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 517418007937 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 517418007938 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 517418007939 Walker A/P-loop; other site 517418007940 ATP binding site [chemical binding]; other site 517418007941 Q-loop/lid; other site 517418007942 ABC transporter signature motif; other site 517418007943 Walker B; other site 517418007944 D-loop; other site 517418007945 H-loop/switch region; other site 517418007946 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 517418007947 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 517418007948 metal binding site [ion binding]; metal-binding site 517418007949 active site 517418007950 I-site; other site 517418007951 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 517418007952 Coenzyme A binding pocket [chemical binding]; other site 517418007953 YoaP-like; Region: YoaP; pfam14268 517418007954 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 517418007955 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_1; cd05017 517418007956 dimer interface [polypeptide binding]; other site 517418007957 active site 517418007958 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 517418007959 dimer interface [polypeptide binding]; other site 517418007960 active site 517418007961 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 517418007962 substrate binding site; other site 517418007963 dimer interface; other site 517418007964 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 517418007965 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 517418007966 TPR repeat; Region: TPR_11; pfam13414 517418007967 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418007968 binding surface 517418007969 TPR motif; other site 517418007970 TPR repeat; Region: TPR_11; pfam13414 517418007971 TPR repeat; Region: TPR_11; pfam13414 517418007972 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418007973 binding surface 517418007974 TPR motif; other site 517418007975 thymidylate kinase; Validated; Region: tmk; PRK00698 517418007976 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 517418007977 TMP-binding site; other site 517418007978 ATP-binding site [chemical binding]; other site 517418007979 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 517418007980 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 517418007981 putative ADP-binding pocket [chemical binding]; other site 517418007982 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 517418007983 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 517418007984 putative ADP-binding pocket [chemical binding]; other site 517418007985 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 517418007986 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 517418007987 putative active site [active] 517418007988 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 517418007989 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 517418007990 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 517418007991 Walker A/P-loop; other site 517418007992 ATP binding site [chemical binding]; other site 517418007993 Q-loop/lid; other site 517418007994 ABC transporter signature motif; other site 517418007995 Walker B; other site 517418007996 D-loop; other site 517418007997 H-loop/switch region; other site 517418007998 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 517418007999 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 517418008000 NAD(P) binding site [chemical binding]; other site 517418008001 active site 517418008002 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 517418008003 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 517418008004 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 517418008005 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 517418008006 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 517418008007 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 517418008008 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 517418008009 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418008010 putative active site [active] 517418008011 heme pocket [chemical binding]; other site 517418008012 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 517418008013 dimer interface [polypeptide binding]; other site 517418008014 phosphorylation site [posttranslational modification] 517418008015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418008016 ATP binding site [chemical binding]; other site 517418008017 Mg2+ binding site [ion binding]; other site 517418008018 G-X-G motif; other site 517418008019 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 517418008020 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 517418008021 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 517418008022 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 517418008023 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 517418008024 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 517418008025 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 517418008026 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 517418008027 zinc binding site [ion binding]; other site 517418008028 putative ligand binding site [chemical binding]; other site 517418008029 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 517418008030 FOG: WD40 repeat [General function prediction only]; Region: COG2319 517418008031 structural tetrad; other site 517418008032 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 517418008033 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 517418008034 dimerization interface [polypeptide binding]; other site 517418008035 putative ATP binding site [chemical binding]; other site 517418008036 putative methyltransferase; Provisional; Region: PRK11524 517418008037 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 517418008038 putative molybdenum utilization protein ModD; Region: modD; TIGR01334 517418008039 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 517418008040 dimerization interface [polypeptide binding]; other site 517418008041 active site 517418008042 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 517418008043 Catalytic site [active] 517418008044 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 517418008045 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 517418008046 GTP-binding protein LepA; Provisional; Region: PRK05433 517418008047 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 517418008048 G1 box; other site 517418008049 putative GEF interaction site [polypeptide binding]; other site 517418008050 GTP/Mg2+ binding site [chemical binding]; other site 517418008051 Switch I region; other site 517418008052 G2 box; other site 517418008053 G3 box; other site 517418008054 Switch II region; other site 517418008055 G4 box; other site 517418008056 G5 box; other site 517418008057 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 517418008058 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 517418008059 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 517418008060 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 517418008061 MarR family; Region: MarR; pfam01047 517418008062 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 517418008063 metal ion-dependent adhesion site (MIDAS); other site 517418008064 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 517418008065 Protein of unknown function (DUF489); Region: DUF489; cl01097 517418008066 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 517418008067 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 517418008068 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 517418008069 putative binding surface; other site 517418008070 active site 517418008071 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 517418008072 Ligand Binding Site [chemical binding]; other site 517418008073 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 517418008074 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 517418008075 catalytic residues [active] 517418008076 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 517418008077 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 517418008078 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 517418008079 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 517418008080 metal-binding site 517418008081 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 517418008082 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 517418008083 metal-binding site 517418008084 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 517418008085 active site 517418008086 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 517418008087 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 517418008088 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 517418008089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 517418008090 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 517418008091 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 517418008092 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 517418008093 Walker A/P-loop; other site 517418008094 ATP binding site [chemical binding]; other site 517418008095 Q-loop/lid; other site 517418008096 ABC transporter signature motif; other site 517418008097 Walker B; other site 517418008098 D-loop; other site 517418008099 H-loop/switch region; other site 517418008100 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 517418008101 putative carbohydrate binding site [chemical binding]; other site 517418008102 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 517418008103 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 517418008104 Right handed beta helix region; Region: Beta_helix; pfam13229 517418008105 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 517418008106 Chain length determinant protein; Region: Wzz; pfam02706 517418008107 Chain length determinant protein; Region: Wzz; cl15801 517418008108 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 517418008109 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 517418008110 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 517418008111 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 517418008112 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 517418008113 Probable Catalytic site; other site 517418008114 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 517418008115 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 517418008116 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 517418008117 substrate binding site [chemical binding]; other site 517418008118 active site 517418008119 catalytic residues [active] 517418008120 heterodimer interface [polypeptide binding]; other site 517418008121 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 517418008122 UbiA prenyltransferase family; Region: UbiA; pfam01040 517418008123 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 517418008124 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 517418008125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418008126 active site 517418008127 phosphorylation site [posttranslational modification] 517418008128 intermolecular recognition site; other site 517418008129 dimerization interface [polypeptide binding]; other site 517418008130 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 517418008131 Zn2+ binding site [ion binding]; other site 517418008132 Mg2+ binding site [ion binding]; other site 517418008133 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 517418008134 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 517418008135 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 517418008136 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 517418008137 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 517418008138 ligand binding site [chemical binding]; other site 517418008139 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 517418008140 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 517418008141 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 517418008142 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 517418008143 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 517418008144 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12900 517418008145 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 517418008146 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 517418008147 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 517418008148 nucleotide binding region [chemical binding]; other site 517418008149 ATP-binding site [chemical binding]; other site 517418008150 SEC-C motif; Region: SEC-C; pfam02810 517418008151 Peptidase family C25; Region: Peptidase_C25; pfam01364 517418008152 active site 517418008153 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 517418008154 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 517418008155 TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329 517418008156 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 517418008157 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 517418008158 dimerization interface [polypeptide binding]; other site 517418008159 ATP binding site [chemical binding]; other site 517418008160 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 517418008161 dimerization interface [polypeptide binding]; other site 517418008162 ATP binding site [chemical binding]; other site 517418008163 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 517418008164 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 517418008165 DNA binding residues [nucleotide binding] 517418008166 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 517418008167 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 517418008168 NADP binding site [chemical binding]; other site 517418008169 homopentamer interface [polypeptide binding]; other site 517418008170 substrate binding site [chemical binding]; other site 517418008171 active site 517418008172 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 517418008173 PhoH-like protein; Region: PhoH; pfam02562 517418008174 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 517418008175 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 517418008176 iron-sulfur cluster [ion binding]; other site 517418008177 [2Fe-2S] cluster binding site [ion binding]; other site 517418008178 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 517418008179 aminodeoxychorismate synthase; Provisional; Region: PRK07508 517418008180 chorismate binding enzyme; Region: Chorismate_bind; cl10555 517418008181 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 517418008182 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 517418008183 homodimer interface [polypeptide binding]; other site 517418008184 substrate-cofactor binding pocket; other site 517418008185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 517418008186 catalytic residue [active] 517418008187 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 517418008188 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 517418008189 dimer interface [polypeptide binding]; other site 517418008190 catalytic triad [active] 517418008191 peroxidatic and resolving cysteines [active] 517418008192 ATP citrate (pro-S)-lyase; Region: PLN02522 517418008193 CoA binding domain; Region: CoA_binding; smart00881 517418008194 CoA-ligase; Region: Ligase_CoA; pfam00549 517418008195 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 517418008196 active site 517418008197 oxalacetate binding site [chemical binding]; other site 517418008198 citrylCoA binding site [chemical binding]; other site 517418008199 coenzyme A binding site [chemical binding]; other site 517418008200 catalytic triad [active] 517418008201 Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045 517418008202 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 517418008203 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 517418008204 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 517418008205 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 517418008206 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 517418008207 hydrogenase 4 subunit D; Validated; Region: PRK06525 517418008208 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 517418008209 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 517418008210 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 517418008211 NADH dehydrogenase subunit 6; Region: ndhG; CHL00016 517418008212 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 517418008213 4Fe-4S binding domain; Region: Fer4; pfam00037 517418008214 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 517418008215 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 517418008216 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 517418008217 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 517418008218 NADH dehydrogenase subunit D; Validated; Region: PRK06075 517418008219 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 517418008220 NADH dehydrogenase subunit B; Provisional; Region: PRK14813 517418008221 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 517418008222 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 517418008223 aromatic arch; other site 517418008224 DCoH dimer interaction site [polypeptide binding]; other site 517418008225 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 517418008226 DCoH tetramer interaction site [polypeptide binding]; other site 517418008227 substrate binding site [chemical binding]; other site 517418008228 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418008229 binding surface 517418008230 TPR motif; other site 517418008231 TPR repeat; Region: TPR_11; pfam13414 517418008232 TPR repeat; Region: TPR_11; pfam13414 517418008233 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418008234 binding surface 517418008235 TPR motif; other site 517418008236 TPR repeat; Region: TPR_11; pfam13414 517418008237 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418008238 binding surface 517418008239 TPR motif; other site 517418008240 TPR repeat; Region: TPR_11; pfam13414 517418008241 TPR repeat; Region: TPR_11; pfam13414 517418008242 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418008243 binding surface 517418008244 TPR motif; other site 517418008245 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 517418008246 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 517418008247 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 517418008248 TPP-binding site [chemical binding]; other site 517418008249 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 517418008250 Ferrochelatase; Region: Ferrochelatase; pfam00762 517418008251 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 517418008252 active site 517418008253 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 517418008254 active site 517418008255 N-terminal domain interface [polypeptide binding]; other site 517418008256 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 517418008257 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 517418008258 active site 517418008259 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 517418008260 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 517418008261 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 517418008262 NeuB family; Region: NeuB; pfam03102 517418008263 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 517418008264 active site 517418008265 motif I; other site 517418008266 motif II; other site 517418008267 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 517418008268 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 517418008269 NAD(P) binding site [chemical binding]; other site 517418008270 active site 517418008271 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 517418008272 putative catalytic site [active] 517418008273 putative metal binding site [ion binding]; other site 517418008274 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 517418008275 putative catalytic site [active] 517418008276 putative phosphate binding site [ion binding]; other site 517418008277 putative phosphate binding site [ion binding]; other site 517418008278 putative metal binding site [ion binding]; other site 517418008279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 517418008280 Major Facilitator Superfamily; Region: MFS_1; pfam07690 517418008281 putative substrate translocation pore; other site 517418008282 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 517418008283 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 517418008284 putative acyl-acceptor binding pocket; other site 517418008285 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 517418008286 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 517418008287 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 517418008288 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 517418008289 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 517418008290 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 517418008291 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 517418008292 active site 517418008293 dimer interface [polypeptide binding]; other site 517418008294 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 517418008295 Ligand Binding Site [chemical binding]; other site 517418008296 Molecular Tunnel; other site 517418008297 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 517418008298 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 517418008299 Coenzyme A binding pocket [chemical binding]; other site 517418008300 ATP-grasp domain; Region: ATP-grasp_4; cl17255 517418008301 Peptidase S8 family domain, uncharacterized subfamily 15; Region: Peptidases_S8_15; cd07498 517418008302 active site 517418008303 catalytic triad [active] 517418008304 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 517418008305 Interdomain contacts; other site 517418008306 Cytokine receptor motif; other site 517418008307 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 517418008308 Interdomain contacts; other site 517418008309 Cytokine receptor motif; other site 517418008310 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 517418008311 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 517418008312 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 517418008313 putative oligomer interface [polypeptide binding]; other site 517418008314 putative active site [active] 517418008315 metal binding site [ion binding]; metal-binding site 517418008316 Membrane protein of unknown function; Region: DUF360; pfam04020 517418008317 heat shock protein 90; Provisional; Region: PRK05218 517418008318 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418008319 ATP binding site [chemical binding]; other site 517418008320 Mg2+ binding site [ion binding]; other site 517418008321 G-X-G motif; other site 517418008322 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 517418008323 Tir chaperone protein (CesT) family; Region: CesT; cl08444 517418008324 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 517418008325 HSP70 interaction site [polypeptide binding]; other site 517418008326 TPR repeat; Region: TPR_11; pfam13414 517418008327 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418008328 binding surface 517418008329 TPR motif; other site 517418008330 Bacterial SH3 domain homologues; Region: SH3b; smart00287 517418008331 Oxygen tolerance; Region: BatD; pfam13584 517418008332 pyrroline-5-carboxylate reductase; Region: PLN02688 517418008333 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 517418008334 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 517418008335 TPR motif; other site 517418008336 binding surface 517418008337 von Willebrand factor type A domain; Region: VWA_2; pfam13519 517418008338 metal ion-dependent adhesion site (MIDAS); other site 517418008339 Protein of unknown function DUF45; Region: DUF45; pfam01863 517418008340 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 517418008341 MarR family; Region: MarR_2; pfam12802 517418008342 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 517418008343 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 517418008344 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 517418008345 polyphosphate kinase; Provisional; Region: PRK05443 517418008346 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 517418008347 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 517418008348 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 517418008349 putative domain interface [polypeptide binding]; other site 517418008350 putative active site [active] 517418008351 catalytic site [active] 517418008352 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 517418008353 putative domain interface [polypeptide binding]; other site 517418008354 putative active site [active] 517418008355 catalytic site [active] 517418008356 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 517418008357 FOG: CBS domain [General function prediction only]; Region: COG0517 517418008358 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 517418008359 Protein of unknown function (DUF3623); Region: DUF3623; cl11843 517418008360 bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566 517418008361 UbiA prenyltransferase family; Region: UbiA; pfam01040 517418008362 CAAX protease self-immunity; Region: Abi; pfam02517 517418008363 Response regulator receiver domain; Region: Response_reg; pfam00072 517418008364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418008365 active site 517418008366 phosphorylation site [posttranslational modification] 517418008367 intermolecular recognition site; other site 517418008368 dimerization interface [polypeptide binding]; other site 517418008369 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 517418008370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418008371 active site 517418008372 phosphorylation site [posttranslational modification] 517418008373 intermolecular recognition site; other site 517418008374 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 517418008375 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418008376 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 517418008377 putative active site [active] 517418008378 heme pocket [chemical binding]; other site 517418008379 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418008380 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 517418008381 putative active site [active] 517418008382 heme pocket [chemical binding]; other site 517418008383 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 517418008384 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 517418008385 dimer interface [polypeptide binding]; other site 517418008386 phosphorylation site [posttranslational modification] 517418008387 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418008388 ATP binding site [chemical binding]; other site 517418008389 Mg2+ binding site [ion binding]; other site 517418008390 G-X-G motif; other site 517418008391 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 517418008392 putative catalytic residues [active] 517418008393 serine acetyltransferase; Provisional; Region: cysE; PRK11132 517418008394 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 517418008395 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 517418008396 trimer interface [polypeptide binding]; other site 517418008397 active site 517418008398 substrate binding site [chemical binding]; other site 517418008399 CoA binding site [chemical binding]; other site 517418008400 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 517418008401 active site 517418008402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 517418008403 Methyltransferase domain; Region: Methyltransf_23; pfam13489 517418008404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 517418008405 S-adenosylmethionine binding site [chemical binding]; other site 517418008406 GAF domain; Region: GAF; pfam01590 517418008407 GAF domain; Region: GAF_2; pfam13185 517418008408 Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module; Region: Serine_rich_CAS; cl07433 517418008409 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 517418008410 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 517418008411 metal binding site [ion binding]; metal-binding site 517418008412 active site 517418008413 I-site; other site 517418008414 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 517418008415 Hexamer/Pentamer interface [polypeptide binding]; other site 517418008416 central pore; other site 517418008417 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 517418008418 Hexamer/Pentamer interface [polypeptide binding]; other site 517418008419 central pore; other site 517418008420 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 517418008421 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 517418008422 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 517418008423 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 517418008424 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 517418008425 DNA binding residues [nucleotide binding] 517418008426 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 517418008427 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 517418008428 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 517418008429 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 517418008430 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 517418008431 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 517418008432 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 517418008433 Walker A/P-loop; other site 517418008434 ATP binding site [chemical binding]; other site 517418008435 Q-loop/lid; other site 517418008436 ABC transporter signature motif; other site 517418008437 Walker B; other site 517418008438 D-loop; other site 517418008439 H-loop/switch region; other site 517418008440 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 517418008441 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 517418008442 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 517418008443 Response regulator receiver domain; Region: Response_reg; pfam00072 517418008444 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418008445 active site 517418008446 phosphorylation site [posttranslational modification] 517418008447 intermolecular recognition site; other site 517418008448 dimerization interface [polypeptide binding]; other site 517418008449 Response regulator receiver domain; Region: Response_reg; pfam00072 517418008450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418008451 active site 517418008452 phosphorylation site [posttranslational modification] 517418008453 intermolecular recognition site; other site 517418008454 dimerization interface [polypeptide binding]; other site 517418008455 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 517418008456 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 517418008457 Walker A/P-loop; other site 517418008458 ATP binding site [chemical binding]; other site 517418008459 Q-loop/lid; other site 517418008460 ABC transporter signature motif; other site 517418008461 Walker B; other site 517418008462 D-loop; other site 517418008463 H-loop/switch region; other site 517418008464 ribonuclease R; Region: RNase_R; TIGR02063 517418008465 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 517418008466 RNB domain; Region: RNB; pfam00773 517418008467 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 517418008468 RNA binding site [nucleotide binding]; other site 517418008469 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 517418008470 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 517418008471 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 517418008472 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 517418008473 Surface antigen; Region: Bac_surface_Ag; pfam01103 517418008474 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 517418008475 Cna protein B-type domain; Region: Cna_B_2; pfam13715 517418008476 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 517418008477 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 517418008478 Putative methyltransferase; Region: Methyltransf_16; pfam10294 517418008479 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 517418008480 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 517418008481 Photosystem P840 reaction-centre cytochrome c-551; Region: Cytochrome-c551; pfam10643 517418008482 Photosystem P840 reaction-centre cytochrome c-551; Region: Cytochrome-c551; pfam10643 517418008483 DNA polymerase I; Provisional; Region: PRK05755 517418008484 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 517418008485 active site 517418008486 metal binding site 1 [ion binding]; metal-binding site 517418008487 putative 5' ssDNA interaction site; other site 517418008488 metal binding site 3; metal-binding site 517418008489 metal binding site 2 [ion binding]; metal-binding site 517418008490 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 517418008491 putative DNA binding site [nucleotide binding]; other site 517418008492 putative metal binding site [ion binding]; other site 517418008493 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 517418008494 active site 517418008495 catalytic site [active] 517418008496 substrate binding site [chemical binding]; other site 517418008497 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 517418008498 active site 517418008499 DNA binding site [nucleotide binding] 517418008500 catalytic site [active] 517418008501 oxaloacetate decarboxylase alpha subunit; Region: oadA; TIGR01108 517418008502 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 517418008503 active site 517418008504 catalytic residues [active] 517418008505 metal binding site [ion binding]; metal-binding site 517418008506 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 517418008507 carboxyltransferase (CT) interaction site; other site 517418008508 biotinylation site [posttranslational modification]; other site 517418008509 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 517418008510 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 517418008511 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 517418008512 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 517418008513 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 517418008514 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 517418008515 Uncharacterized conserved protein [Function unknown]; Region: COG0432 517418008516 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 517418008517 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 517418008518 Ligand Binding Site [chemical binding]; other site 517418008519 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 517418008520 classical (c) SDRs; Region: SDR_c; cd05233 517418008521 NAD(P) binding site [chemical binding]; other site 517418008522 active site 517418008523 hypothetical protein; Provisional; Region: PRK09256 517418008524 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 517418008525 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 517418008526 Coenzyme A binding pocket [chemical binding]; other site 517418008527 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 517418008528 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 517418008529 Mechanosensitive ion channel; Region: MS_channel; pfam00924 517418008530 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 517418008531 active site 517418008532 DNA binding site [nucleotide binding] 517418008533 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 517418008534 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 517418008535 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 517418008536 Magnesium ion binding site [ion binding]; other site 517418008537 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 517418008538 ParB-like nuclease domain; Region: ParB; smart00470 517418008539 dihydrodipicolinate reductase; Provisional; Region: PRK00048 517418008540 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 517418008541 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 517418008542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 517418008543 putative substrate translocation pore; other site 517418008544 PUCC protein; Region: PUCC; pfam03209 517418008545 TRL-like protein family; Region: TRL; pfam13146 517418008546 cyclase homology domain; Region: CHD; cd07302 517418008547 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 517418008548 nucleotidyl binding site; other site 517418008549 metal binding site [ion binding]; metal-binding site 517418008550 dimer interface [polypeptide binding]; other site 517418008551 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 517418008552 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 517418008553 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 517418008554 active site 517418008555 catalytic site [active] 517418008556 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 517418008557 Malic enzyme, N-terminal domain; Region: malic; pfam00390 517418008558 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 517418008559 putative NAD(P) binding site [chemical binding]; other site 517418008560 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 517418008561 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 517418008562 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 517418008563 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 517418008564 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 517418008565 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 517418008566 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 517418008567 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 517418008568 prolyl-tRNA synthetase; Provisional; Region: PRK08661 517418008569 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 517418008570 dimer interface [polypeptide binding]; other site 517418008571 motif 1; other site 517418008572 active site 517418008573 motif 2; other site 517418008574 motif 3; other site 517418008575 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 517418008576 anticodon binding site; other site 517418008577 zinc-binding site [ion binding]; other site 517418008578 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 517418008579 active site 517418008580 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 517418008581 putative catalytic site [active] 517418008582 putative metal binding site [ion binding]; other site 517418008583 putative phosphate binding site [ion binding]; other site 517418008584 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 517418008585 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 517418008586 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 517418008587 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 517418008588 motif II; other site 517418008589 methionine sulfoxide reductase A; Provisional; Region: PRK14054 517418008590 Alg9-like mannosyltransferase family; Region: Glyco_transf_22; cl17751 517418008591 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 517418008592 Cna protein B-type domain; Region: Cna_B_2; pfam13715 517418008593 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 517418008594 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 517418008595 N-terminal plug; other site 517418008596 ligand-binding site [chemical binding]; other site 517418008597 RES domain; Region: RES; pfam08808 517418008598 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 517418008599 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 517418008600 CoA binding domain; Region: CoA_binding; smart00881 517418008601 CoA-ligase; Region: Ligase_CoA; pfam00549 517418008602 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 517418008603 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 517418008604 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 517418008605 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 517418008606 catalytic residue [active] 517418008607 putative FPP diphosphate binding site; other site 517418008608 putative FPP binding hydrophobic cleft; other site 517418008609 dimer interface [polypeptide binding]; other site 517418008610 putative IPP diphosphate binding site; other site 517418008611 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 517418008612 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 517418008613 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 517418008614 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 517418008615 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 517418008616 Surface antigen; Region: Bac_surface_Ag; pfam01103 517418008617 NAD-dependent deacetylase; Provisional; Region: PRK00481 517418008618 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 517418008619 NAD+ binding site [chemical binding]; other site 517418008620 substrate binding site [chemical binding]; other site 517418008621 Zn binding site [ion binding]; other site 517418008622 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 517418008623 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 517418008624 active site 517418008625 HIGH motif; other site 517418008626 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 517418008627 active site 517418008628 KMSKS motif; other site 517418008629 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 517418008630 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 517418008631 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 517418008632 trimerization site [polypeptide binding]; other site 517418008633 active site 517418008634 cysteine desulfurase; Provisional; Region: PRK14012 517418008635 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 517418008636 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 517418008637 catalytic residue [active] 517418008638 Rrf2 family protein; Region: rrf2_super; TIGR00738 517418008639 Transcriptional regulator; Region: Rrf2; pfam02082 517418008640 hydrolase, alpha/beta fold family protein; Region: PLN02824 517418008641 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 517418008642 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 517418008643 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 517418008644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418008645 active site 517418008646 phosphorylation site [posttranslational modification] 517418008647 intermolecular recognition site; other site 517418008648 dimerization interface [polypeptide binding]; other site 517418008649 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 517418008650 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 517418008651 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 517418008652 DNA binding residues [nucleotide binding] 517418008653 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 517418008654 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 517418008655 NADP binding site [chemical binding]; other site 517418008656 active site 517418008657 putative substrate binding site [chemical binding]; other site 517418008658 FOG: WD40 repeat [General function prediction only]; Region: COG2319 517418008659 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 517418008660 structural tetrad; other site 517418008661 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 517418008662 Part of AAA domain; Region: AAA_19; pfam13245 517418008663 Family description; Region: UvrD_C_2; pfam13538 517418008664 Response regulator receiver domain; Region: Response_reg; pfam00072 517418008665 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418008666 active site 517418008667 phosphorylation site [posttranslational modification] 517418008668 dimerization interface [polypeptide binding]; other site 517418008669 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418008670 PAS fold; Region: PAS_3; pfam08447 517418008671 putative active site [active] 517418008672 heme pocket [chemical binding]; other site 517418008673 PAS domain S-box; Region: sensory_box; TIGR00229 517418008674 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418008675 putative active site [active] 517418008676 heme pocket [chemical binding]; other site 517418008677 PAS domain S-box; Region: sensory_box; TIGR00229 517418008678 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418008679 putative active site [active] 517418008680 heme pocket [chemical binding]; other site 517418008681 PAS domain S-box; Region: sensory_box; TIGR00229 517418008682 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418008683 putative active site [active] 517418008684 heme pocket [chemical binding]; other site 517418008685 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 517418008686 GAF domain; Region: GAF; pfam01590 517418008687 PAS fold; Region: PAS_4; pfam08448 517418008688 PAS domain S-box; Region: sensory_box; TIGR00229 517418008689 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418008690 putative active site [active] 517418008691 heme pocket [chemical binding]; other site 517418008692 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418008693 PAS domain; Region: PAS_9; pfam13426 517418008694 putative active site [active] 517418008695 heme pocket [chemical binding]; other site 517418008696 PAS fold; Region: PAS_4; pfam08448 517418008697 PAS domain S-box; Region: sensory_box; TIGR00229 517418008698 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418008699 putative active site [active] 517418008700 heme pocket [chemical binding]; other site 517418008701 hypothetical protein; Provisional; Region: PRK13560 517418008702 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418008703 putative active site [active] 517418008704 heme pocket [chemical binding]; other site 517418008705 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418008706 putative active site [active] 517418008707 heme pocket [chemical binding]; other site 517418008708 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418008709 putative active site [active] 517418008710 heme pocket [chemical binding]; other site 517418008711 Histidine kinase; Region: HisKA_2; pfam07568 517418008712 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418008713 ATP binding site [chemical binding]; other site 517418008714 Mg2+ binding site [ion binding]; other site 517418008715 G-X-G motif; other site 517418008716 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 517418008717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418008718 active site 517418008719 phosphorylation site [posttranslational modification] 517418008720 intermolecular recognition site; other site 517418008721 dimerization interface [polypeptide binding]; other site 517418008722 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 517418008723 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418008724 putative active site [active] 517418008725 heme pocket [chemical binding]; other site 517418008726 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 517418008727 dimer interface [polypeptide binding]; other site 517418008728 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418008729 ATP binding site [chemical binding]; other site 517418008730 G-X-G motif; other site 517418008731 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 517418008732 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920 517418008733 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920 517418008734 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 517418008735 Protein export membrane protein; Region: SecD_SecF; cl14618 517418008736 Protein export membrane protein; Region: SecD_SecF; cl14618 517418008737 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 517418008738 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 517418008739 HlyD family secretion protein; Region: HlyD_3; pfam13437 517418008740 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 517418008741 Domain of unknown function DUF302; Region: DUF302; pfam03625 517418008742 Domain of unknown function DUF302; Region: DUF302; pfam03625 517418008743 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 517418008744 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 517418008745 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 517418008746 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 517418008747 active site 517418008748 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 517418008749 binding surface 517418008750 TPR repeat; Region: TPR_11; pfam13414 517418008751 TPR motif; other site 517418008752 Methyltransferase domain; Region: Methyltransf_31; pfam13847 517418008753 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 517418008754 S-adenosylmethionine binding site [chemical binding]; other site 517418008755 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 517418008756 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 517418008757 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 517418008758 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 517418008759 peptide binding site [polypeptide binding]; other site 517418008760 2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284 517418008761 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202 517418008762 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 517418008763 putative NAD(P) binding site [chemical binding]; other site 517418008764 chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016 517418008765 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 517418008766 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 517418008767 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 517418008768 DNA binding residues [nucleotide binding] 517418008769 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 517418008770 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 517418008771 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 517418008772 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 517418008773 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 517418008774 carboxyltransferase (CT) interaction site; other site 517418008775 biotinylation site [posttranslational modification]; other site 517418008776 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 517418008777 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 517418008778 Cna protein B-type domain; Region: Cna_B_2; pfam13715 517418008779 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 517418008780 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 517418008781 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418008782 PAS domain; Region: PAS_9; pfam13426 517418008783 putative active site [active] 517418008784 heme pocket [chemical binding]; other site 517418008785 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 517418008786 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 517418008787 putative active site [active] 517418008788 heme pocket [chemical binding]; other site 517418008789 PAS fold; Region: PAS_4; pfam08448 517418008790 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 517418008791 dimer interface [polypeptide binding]; other site 517418008792 phosphorylation site [posttranslational modification] 517418008793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 517418008794 ATP binding site [chemical binding]; other site 517418008795 Mg2+ binding site [ion binding]; other site 517418008796 G-X-G motif; other site 517418008797 Response regulator receiver domain; Region: Response_reg; pfam00072 517418008798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 517418008799 active site 517418008800 phosphorylation site [posttranslational modification] 517418008801 intermolecular recognition site; other site 517418008802 dimerization interface [polypeptide binding]; other site 517418008803 Domain of unknown function DUF77; Region: DUF77; pfam01910 517418008804 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 517418008805 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 517418008806 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 517418008807 PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395 517418008808 active site 517418008809 membrane protein insertase; Provisional; Region: PRK01318 517418008810 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 517418008811 Haemolytic domain; Region: Haemolytic; pfam01809 517418008812 ribonuclease P; Reviewed; Region: rnpA; PRK01903 517418008813 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399