-- dump date   	20140619_041648
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
243365000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
243365000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
243365000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243365000004	Walker A motif; other site
243365000005	ATP binding site [chemical binding]; other site
243365000006	Walker B motif; other site
243365000007	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
243365000008	arginine finger; other site
243365000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
243365000010	DnaA box-binding interface [nucleotide binding]; other site
243365000011	DNA polymerase III subunit beta; Validated; Region: PRK05643
243365000012	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
243365000013	putative DNA binding surface [nucleotide binding]; other site
243365000014	dimer interface [polypeptide binding]; other site
243365000015	beta-clamp/clamp loader binding surface; other site
243365000016	beta-clamp/translesion DNA polymerase binding surface; other site
243365000017	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
243365000018	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365000019	Mg2+ binding site [ion binding]; other site
243365000020	G-X-G motif; other site
243365000021	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
243365000022	anchoring element; other site
243365000023	dimer interface [polypeptide binding]; other site
243365000024	ATP binding site [chemical binding]; other site
243365000025	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
243365000026	active site
243365000027	putative metal-binding site [ion binding]; other site
243365000028	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
243365000029	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
243365000030	HTH-like domain; Region: HTH_21; pfam13276
243365000031	Integrase core domain; Region: rve; pfam00665
243365000032	Integrase core domain; Region: rve_3; pfam13683
243365000033	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
243365000034	DNA methylase; Region: N6_N4_Mtase; pfam01555
243365000035	GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401
243365000036	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
243365000037	active site
243365000038	Domain of unknown function (DUF2357); Region: DUF2357; pfam09823
243365000039	Protein of unknown function (DUF524); Region: DUF524; pfam04411
243365000040	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
243365000041	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
243365000042	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
243365000043	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
243365000044	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
243365000045	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
243365000046	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
243365000047	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
243365000048	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
243365000049	ATP-grasp domain; Region: ATP-grasp_4; cl17255
243365000050	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
243365000051	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
243365000052	carboxyltransferase (CT) interaction site; other site
243365000053	biotinylation site [posttranslational modification]; other site
243365000054	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
243365000055	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
243365000056	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365000057	putative substrate translocation pore; other site
243365000058	hypothetical protein; Provisional; Region: PRK07505
243365000059	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
243365000060	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
243365000061	catalytic residue [active]
243365000062	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
243365000063	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
243365000064	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
243365000065	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
243365000066	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
243365000067	Peptidase family M23; Region: Peptidase_M23; pfam01551
243365000068	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
243365000069	catalytic residue [active]
243365000070	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
243365000071	Cache domain; Region: Cache_1; pfam02743
243365000072	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243365000073	dimerization interface [polypeptide binding]; other site
243365000074	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365000075	dimer interface [polypeptide binding]; other site
243365000076	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
243365000077	putative CheW interface [polypeptide binding]; other site
243365000078	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
243365000079	nudix motif; other site
243365000080	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
243365000081	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
243365000082	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
243365000083	active site
243365000084	putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198
243365000085	pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569
243365000086	active site
243365000087	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
243365000088	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
243365000089	RES domain; Region: RES; pfam08808
243365000090	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
243365000091	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
243365000092	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365000093	homodimer interface [polypeptide binding]; other site
243365000094	catalytic residue [active]
243365000095	frataxin-like protein; Provisional; Region: cyaY; PRK00446
243365000096	putative iron binding site [ion binding]; other site
243365000097	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
243365000098	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
243365000099	Sel1 repeat; Region: Sel1; cl02723
243365000100	Sel1-like repeats; Region: SEL1; smart00671
243365000101	Sel1-like repeats; Region: SEL1; smart00671
243365000102	serine acetyltransferase; Provisional; Region: cysE; PRK11132
243365000103	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
243365000104	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
243365000105	trimer interface [polypeptide binding]; other site
243365000106	active site
243365000107	substrate binding site [chemical binding]; other site
243365000108	CoA binding site [chemical binding]; other site
243365000109	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
243365000110	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
243365000111	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
243365000112	MASE1; Region: MASE1; pfam05231
243365000113	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365000114	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365000115	metal binding site [ion binding]; metal-binding site
243365000116	active site
243365000117	I-site; other site
243365000118	Transcriptional regulators [Transcription]; Region: MarR; COG1846
243365000119	MarR family; Region: MarR; pfam01047
243365000120	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365000121	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
243365000122	putative substrate translocation pore; other site
243365000123	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
243365000124	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365000125	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
243365000126	dimerization interface [polypeptide binding]; other site
243365000127	substrate binding pocket [chemical binding]; other site
243365000128	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
243365000129	HemY protein N-terminus; Region: HemY_N; pfam07219
243365000130	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
243365000131	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
243365000132	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
243365000133	active site
243365000134	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
243365000135	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
243365000136	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
243365000137	domain interfaces; other site
243365000138	active site
243365000139	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
243365000140	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
243365000141	M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879
243365000142	Peptidase family M28; Region: Peptidase_M28; pfam04389
243365000143	active site
243365000144	metal binding site [ion binding]; metal-binding site
243365000145	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
243365000146	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
243365000147	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
243365000148	active site
243365000149	Zn binding site [ion binding]; other site
243365000150	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
243365000151	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
243365000152	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
243365000153	S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010
243365000154	active site
243365000155	Zn binding site [ion binding]; other site
243365000156	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365000157	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365000158	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
243365000159	putative dimerization interface [polypeptide binding]; other site
243365000160	Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916
243365000161	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
243365000162	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
243365000163	ATP binding site [chemical binding]; other site
243365000164	putative Mg++ binding site [ion binding]; other site
243365000165	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243365000166	nucleotide binding region [chemical binding]; other site
243365000167	ATP-binding site [chemical binding]; other site
243365000168	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
243365000169	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
243365000170	inhibitor-cofactor binding pocket; inhibition site
243365000171	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365000172	catalytic residue [active]
243365000173	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
243365000174	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419
243365000175	putative active site [active]
243365000176	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
243365000177	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
243365000178	Walker A/P-loop; other site
243365000179	ATP binding site [chemical binding]; other site
243365000180	Q-loop/lid; other site
243365000181	ABC transporter signature motif; other site
243365000182	Walker B; other site
243365000183	D-loop; other site
243365000184	H-loop/switch region; other site
243365000185	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
243365000186	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
243365000187	HlyD family secretion protein; Region: HlyD_3; pfam13437
243365000188	putative geopeptide radical SAM maturase; Region: geopep_mat_rSAM; TIGR04280
243365000189	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243365000190	FeS/SAM binding site; other site
243365000191	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
243365000192	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
243365000193	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365000194	active site
243365000195	phosphorylation site [posttranslational modification]
243365000196	intermolecular recognition site; other site
243365000197	dimerization interface [polypeptide binding]; other site
243365000198	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243365000199	Walker A motif; other site
243365000200	ATP binding site [chemical binding]; other site
243365000201	Walker B motif; other site
243365000202	arginine finger; other site
243365000203	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
243365000204	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243365000205	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243365000206	dimer interface [polypeptide binding]; other site
243365000207	phosphorylation site [posttranslational modification]
243365000208	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365000209	ATP binding site [chemical binding]; other site
243365000210	Mg2+ binding site [ion binding]; other site
243365000211	G-X-G motif; other site
243365000212	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
243365000213	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
243365000214	CAP-like domain; other site
243365000215	active site
243365000216	primary dimer interface [polypeptide binding]; other site
243365000217	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365000218	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
243365000219	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
243365000220	Coenzyme A binding pocket [chemical binding]; other site
243365000221	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
243365000222	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
243365000223	N-terminal plug; other site
243365000224	ligand-binding site [chemical binding]; other site
243365000225	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
243365000226	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
243365000227	tRNA; other site
243365000228	putative tRNA binding site [nucleotide binding]; other site
243365000229	putative NADP binding site [chemical binding]; other site
243365000230	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
243365000231	peptide chain release factor 1; Validated; Region: prfA; PRK00591
243365000232	This domain is found in peptide chain release factors; Region: PCRF; smart00937
243365000233	RF-1 domain; Region: RF-1; pfam00472
243365000234	Cytochrome c; Region: Cytochrom_C; cl11414
243365000235	Cytochrome c; Region: Cytochrom_C; pfam00034
243365000236	Predicted transporter component [General function prediction only]; Region: COG2391
243365000237	Sulphur transport; Region: Sulf_transp; pfam04143
243365000238	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
243365000239	Predicted transporter component [General function prediction only]; Region: COG2391
243365000240	Sulphur transport; Region: Sulf_transp; pfam04143
243365000241	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
243365000242	dimerization interface [polypeptide binding]; other site
243365000243	putative DNA binding site [nucleotide binding]; other site
243365000244	putative Zn2+ binding site [ion binding]; other site
243365000245	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
243365000246	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
243365000247	B12 binding site [chemical binding]; other site
243365000248	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243365000249	Radical SAM superfamily; Region: Radical_SAM; pfam04055
243365000250	FeS/SAM binding site; other site
243365000251	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
243365000252	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
243365000253	DNA binding site [nucleotide binding]
243365000254	active site
243365000255	hypothetical protein; Provisional; Region: PRK11528
243365000256	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
243365000257	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365000258	active site
243365000259	phosphorylation site [posttranslational modification]
243365000260	intermolecular recognition site; other site
243365000261	dimerization interface [polypeptide binding]; other site
243365000262	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365000263	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365000264	metal binding site [ion binding]; metal-binding site
243365000265	active site
243365000266	I-site; other site
243365000267	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
243365000268	RNB domain; Region: RNB; pfam00773
243365000269	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
243365000270	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
243365000271	acyl-activating enzyme (AAE) consensus motif; other site
243365000272	putative AMP binding site [chemical binding]; other site
243365000273	putative active site [active]
243365000274	putative CoA binding site [chemical binding]; other site
243365000275	HDOD domain; Region: HDOD; pfam08668
243365000276	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
243365000277	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
243365000278	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
243365000279	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365000280	dimer interface [polypeptide binding]; other site
243365000281	putative CheW interface [polypeptide binding]; other site
243365000282	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413
243365000283	active site
243365000284	catalytic residues [active]
243365000285	Methyltransferase domain; Region: Methyltransf_32; pfam13679
243365000286	Methyltransferase domain; Region: Methyltransf_31; pfam13847
243365000287	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
243365000288	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
243365000289	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
243365000290	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
243365000291	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
243365000292	ligand binding site [chemical binding]; other site
243365000293	homodimer interface [polypeptide binding]; other site
243365000294	NAD(P) binding site [chemical binding]; other site
243365000295	trimer interface B [polypeptide binding]; other site
243365000296	trimer interface A [polypeptide binding]; other site
243365000297	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243365000298	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243365000299	substrate binding pocket [chemical binding]; other site
243365000300	membrane-bound complex binding site; other site
243365000301	hinge residues; other site
243365000302	Histidine kinase; Region: His_kinase; pfam06580
243365000303	Predicted integral membrane protein [Function unknown]; Region: COG3548
243365000304	Protein of unknown function (DUF3460); Region: DUF3460; pfam11943
243365000305	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
243365000306	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365000307	S-adenosylmethionine binding site [chemical binding]; other site
243365000308	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
243365000309	TolR protein; Region: tolR; TIGR02801
243365000310	TolA protein; Region: tolA_full; TIGR02794
243365000311	TonB C terminal; Region: TonB_2; pfam13103
243365000312	translocation protein TolB; Provisional; Region: tolB; PRK02889
243365000313	TolB amino-terminal domain; Region: TolB_N; pfam04052
243365000314	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
243365000315	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
243365000316	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
243365000317	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
243365000318	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
243365000319	ligand binding site [chemical binding]; other site
243365000320	Protein of unknown function (DUF2730); Region: DUF2730; pfam10805
243365000321	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
243365000322	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243365000323	TPR motif; other site
243365000324	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
243365000325	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
243365000326	putative DNA binding site [nucleotide binding]; other site
243365000327	putative Zn2+ binding site [ion binding]; other site
243365000328	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
243365000329	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
243365000330	aspartate racemase; Region: asp_race; TIGR00035
243365000331	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
243365000332	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243365000333	argininosuccinate lyase; Provisional; Region: PRK00855
243365000334	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
243365000335	active sites [active]
243365000336	tetramer interface [polypeptide binding]; other site
243365000337	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243365000338	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243365000339	substrate binding pocket [chemical binding]; other site
243365000340	membrane-bound complex binding site; other site
243365000341	hinge residues; other site
243365000342	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
243365000343	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
243365000344	Walker A/P-loop; other site
243365000345	ATP binding site [chemical binding]; other site
243365000346	Q-loop/lid; other site
243365000347	ABC transporter signature motif; other site
243365000348	Walker B; other site
243365000349	D-loop; other site
243365000350	H-loop/switch region; other site
243365000351	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
243365000352	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365000353	dimer interface [polypeptide binding]; other site
243365000354	conserved gate region; other site
243365000355	putative PBP binding loops; other site
243365000356	ABC-ATPase subunit interface; other site
243365000357	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
243365000358	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365000359	dimer interface [polypeptide binding]; other site
243365000360	conserved gate region; other site
243365000361	putative PBP binding loops; other site
243365000362	ABC-ATPase subunit interface; other site
243365000363	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243365000364	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243365000365	substrate binding pocket [chemical binding]; other site
243365000366	membrane-bound complex binding site; other site
243365000367	hinge residues; other site
243365000368	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
243365000369	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365000370	S-adenosylmethionine binding site [chemical binding]; other site
243365000371	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365000372	multidrug efflux system protein MdtL; Provisional; Region: PRK10473
243365000373	putative substrate translocation pore; other site
243365000374	Maf-like protein; Region: Maf; pfam02545
243365000375	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
243365000376	active site
243365000377	dimer interface [polypeptide binding]; other site
243365000378	ribonuclease G; Provisional; Region: PRK11712
243365000379	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
243365000380	homodimer interface [polypeptide binding]; other site
243365000381	oligonucleotide binding site [chemical binding]; other site
243365000382	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
243365000383	Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes.  All members...; Region: cytidine_deaminase-like; cl00269
243365000384	active site
243365000385	Zn binding site [ion binding]; other site
243365000386	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
243365000387	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
243365000388	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
243365000389	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
243365000390	active site
243365000391	Benzoate membrane transport protein; Region: BenE; pfam03594
243365000392	benzoate transporter; Region: benE; TIGR00843
243365000393	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
243365000394	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
243365000395	DNA-binding site [nucleotide binding]; DNA binding site
243365000396	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
243365000397	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365000398	homodimer interface [polypeptide binding]; other site
243365000399	catalytic residue [active]
243365000400	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365000401	Coenzyme A binding pocket [chemical binding]; other site
243365000402	hydroxyglutarate oxidase; Provisional; Region: PRK11728
243365000403	Predicted dehydrogenase [General function prediction only]; Region: COG0579
243365000404	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
243365000405	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
243365000406	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
243365000407	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243365000408	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
243365000409	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365000410	putative substrate translocation pore; other site
243365000411	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365000412	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365000413	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476
243365000414	putative effector binding pocket; other site
243365000415	putative dimerization interface [polypeptide binding]; other site
243365000416	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
243365000417	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
243365000418	active site
243365000419	intersubunit interface [polypeptide binding]; other site
243365000420	catalytic residue [active]
243365000421	phosphogluconate dehydratase; Validated; Region: PRK09054
243365000422	6-phosphogluconate dehydratase; Region: edd; TIGR01196
243365000423	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
243365000424	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
243365000425	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
243365000426	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
243365000427	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
243365000428	putative active site [active]
243365000429	glucokinase; Provisional; Region: glk; PRK00292
243365000430	glucokinase, proteobacterial type; Region: glk; TIGR00749
243365000431	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
243365000432	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
243365000433	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
243365000434	putative active site [active]
243365000435	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
243365000436	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
243365000437	active site
243365000438	dimer interface [polypeptide binding]; other site
243365000439	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
243365000440	dimer interface [polypeptide binding]; other site
243365000441	active site
243365000442	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
243365000443	active site
243365000444	pyrophosphate binding site [ion binding]; other site
243365000445	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
243365000446	substrate binding site [chemical binding]; other site
243365000447	dimer interface [polypeptide binding]; other site
243365000448	ATP binding site [chemical binding]; other site
243365000449	Rubredoxin [Energy production and conversion]; Region: COG1773
243365000450	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
243365000451	iron binding site [ion binding]; other site
243365000452	Peptidase family M48; Region: Peptidase_M48; pfam01435
243365000453	Protein of unknown function (DUF419); Region: DUF419; cl15265
243365000454	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
243365000455	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
243365000456	putative active site [active]
243365000457	putative metal binding residues [ion binding]; other site
243365000458	signature motif; other site
243365000459	putative dimer interface [polypeptide binding]; other site
243365000460	putative phosphate binding site [ion binding]; other site
243365000461	sulfite:cytochrome c oxidoreductase subunit A (SorA), molybdopterin binding domain. SorA is involved in oxidation of sulfur compounds during chemolithothrophic growth. Together with SorB, a small c-type heme containing subunit, it forms a hetrodimer. It; Region: bact_SorA_Moco; cd02114
243365000462	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
243365000463	Moco binding site; other site
243365000464	metal coordination site [ion binding]; other site
243365000465	putative dimerization interface [polypeptide binding]; other site
243365000466	CAAX protease self-immunity; Region: Abi; pfam02517
243365000467	AIR carboxylase; Region: AIRC; pfam00731
243365000468	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
243365000469	XdhC Rossmann domain; Region: XdhC_C; pfam13478
243365000470	ATP-grasp domain; Region: ATP-grasp; pfam02222
243365000471	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
243365000472	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
243365000473	active site
243365000474	metal binding site [ion binding]; metal-binding site
243365000475	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
243365000476	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
243365000477	active site
243365000478	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
243365000479	ATP binding site [chemical binding]; other site
243365000480	active site
243365000481	substrate binding site [chemical binding]; other site
243365000482	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
243365000483	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
243365000484	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
243365000485	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
243365000486	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
243365000487	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
243365000488	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
243365000489	active site
243365000490	FMN binding site [chemical binding]; other site
243365000491	2,4-decadienoyl-CoA binding site; other site
243365000492	catalytic residue [active]
243365000493	4Fe-4S cluster binding site [ion binding]; other site
243365000494	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
243365000495	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365000496	S-adenosylmethionine binding site [chemical binding]; other site
243365000497	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
243365000498	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
243365000499	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
243365000500	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
243365000501	Cytochrome c; Region: Cytochrom_C; cl11414
243365000502	YGGT family; Region: YGGT; pfam02325
243365000503	YGGT family; Region: YGGT; pfam02325
243365000504	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
243365000505	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
243365000506	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
243365000507	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
243365000508	catalytic residue [active]
243365000509	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
243365000510	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
243365000511	Walker A motif; other site
243365000512	ATP binding site [chemical binding]; other site
243365000513	Walker B motif; other site
243365000514	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
243365000515	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
243365000516	Walker A motif; other site
243365000517	ATP binding site [chemical binding]; other site
243365000518	Walker B motif; other site
243365000519	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365000520	Response regulator receiver domain; Region: Response_reg; pfam00072
243365000521	active site
243365000522	phosphorylation site [posttranslational modification]
243365000523	intermolecular recognition site; other site
243365000524	dimerization interface [polypeptide binding]; other site
243365000525	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243365000526	TPR motif; other site
243365000527	binding surface
243365000528	TPR repeat; Region: TPR_11; pfam13414
243365000529	Response regulator receiver domain; Region: Response_reg; pfam00072
243365000530	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365000531	active site
243365000532	phosphorylation site [posttranslational modification]
243365000533	intermolecular recognition site; other site
243365000534	dimerization interface [polypeptide binding]; other site
243365000535	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
243365000536	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243365000537	TPR motif; other site
243365000538	binding surface
243365000539	TPR repeat; Region: TPR_11; pfam13414
243365000540	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
243365000541	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
243365000542	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
243365000543	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
243365000544	MoaE homodimer interface [polypeptide binding]; other site
243365000545	MoaD interaction [polypeptide binding]; other site
243365000546	active site residues [active]
243365000547	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
243365000548	MoaE interaction surface [polypeptide binding]; other site
243365000549	MoeB interaction surface [polypeptide binding]; other site
243365000550	thiocarboxylated glycine; other site
243365000551	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
243365000552	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
243365000553	intersubunit interface [polypeptide binding]; other site
243365000554	active site
243365000555	zinc binding site [ion binding]; other site
243365000556	Na+ binding site [ion binding]; other site
243365000557	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
243365000558	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
243365000559	Phosphoglycerate kinase; Region: PGK; pfam00162
243365000560	substrate binding site [chemical binding]; other site
243365000561	hinge regions; other site
243365000562	ADP binding site [chemical binding]; other site
243365000563	catalytic site [active]
243365000564	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
243365000565	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
243365000566	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
243365000567	transketolase; Reviewed; Region: PRK12753
243365000568	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
243365000569	TPP-binding site [chemical binding]; other site
243365000570	dimer interface [polypeptide binding]; other site
243365000571	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
243365000572	PYR/PP interface [polypeptide binding]; other site
243365000573	dimer interface [polypeptide binding]; other site
243365000574	TPP binding site [chemical binding]; other site
243365000575	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
243365000576	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
243365000577	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
243365000578	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
243365000579	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
243365000580	putative C-terminal domain interface [polypeptide binding]; other site
243365000581	putative GSH binding site (G-site) [chemical binding]; other site
243365000582	putative dimer interface [polypeptide binding]; other site
243365000583	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
243365000584	putative N-terminal domain interface [polypeptide binding]; other site
243365000585	putative dimer interface [polypeptide binding]; other site
243365000586	putative substrate binding pocket (H-site) [chemical binding]; other site
243365000587	Predicted transcriptional regulator [Transcription]; Region: COG2378
243365000588	HTH domain; Region: HTH_11; pfam08279
243365000589	WYL domain; Region: WYL; pfam13280
243365000590	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
243365000591	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
243365000592	active site
243365000593	Predicted membrane protein [Function unknown]; Region: COG3174
243365000594	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
243365000595	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
243365000596	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
243365000597	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
243365000598	substrate binding pocket [chemical binding]; other site
243365000599	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
243365000600	B12 binding site [chemical binding]; other site
243365000601	cobalt ligand [ion binding]; other site
243365000602	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
243365000603	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243365000604	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243365000605	substrate binding pocket [chemical binding]; other site
243365000606	membrane-bound complex binding site; other site
243365000607	hinge residues; other site
243365000608	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
243365000609	Part of AAA domain; Region: AAA_19; pfam13245
243365000610	Family description; Region: UvrD_C_2; pfam13538
243365000611	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
243365000612	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365000613	active site
243365000614	phosphorylation site [posttranslational modification]
243365000615	intermolecular recognition site; other site
243365000616	dimerization interface [polypeptide binding]; other site
243365000617	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
243365000618	TPR motif; other site
243365000619	binding surface
243365000620	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
243365000621	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365000622	active site
243365000623	phosphorylation site [posttranslational modification]
243365000624	intermolecular recognition site; other site
243365000625	dimerization interface [polypeptide binding]; other site
243365000626	LytTr DNA-binding domain; Region: LytTR; pfam04397
243365000627	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365000628	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365000629	metal binding site [ion binding]; metal-binding site
243365000630	active site
243365000631	I-site; other site
243365000632	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
243365000633	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
243365000634	MarR family; Region: MarR; pfam01047
243365000635	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
243365000636	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
243365000637	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
243365000638	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
243365000639	NADP binding site [chemical binding]; other site
243365000640	dimer interface [polypeptide binding]; other site
243365000641	osmolarity response regulator; Provisional; Region: ompR; PRK09468
243365000642	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365000643	active site
243365000644	phosphorylation site [posttranslational modification]
243365000645	intermolecular recognition site; other site
243365000646	dimerization interface [polypeptide binding]; other site
243365000647	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
243365000648	DNA binding site [nucleotide binding]
243365000649	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243365000650	dimerization interface [polypeptide binding]; other site
243365000651	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
243365000652	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365000653	ATP binding site [chemical binding]; other site
243365000654	G-X-G motif; other site
243365000655	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365000656	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365000657	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
243365000658	dimerization interface [polypeptide binding]; other site
243365000659	EamA-like transporter family; Region: EamA; pfam00892
243365000660	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
243365000661	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
243365000662	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
243365000663	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
243365000664	DNA binding site [nucleotide binding]
243365000665	active site
243365000666	Protein of unknown function (DUF1203); Region: DUF1203; pfam06718
243365000667	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_27; cd04640
243365000668	Chorismate lyase; Region: Chor_lyase; cl01230
243365000669	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243365000670	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243365000671	substrate binding pocket [chemical binding]; other site
243365000672	membrane-bound complex binding site; other site
243365000673	hinge residues; other site
243365000674	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
243365000675	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
243365000676	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
243365000677	Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075
243365000678	putative active site [active]
243365000679	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
243365000680	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
243365000681	putative metal binding site; other site
243365000682	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
243365000683	putative dimer interface [polypeptide binding]; other site
243365000684	catalytic triad [active]
243365000685	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365000686	Coenzyme A binding pocket [chemical binding]; other site
243365000687	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
243365000688	Domain of unknown function DUF21; Region: DUF21; pfam01595
243365000689	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
243365000690	Transporter associated domain; Region: CorC_HlyC; smart01091
243365000691	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
243365000692	ligand binding site [chemical binding]; other site
243365000693	active site
243365000694	UGI interface [polypeptide binding]; other site
243365000695	catalytic site [active]
243365000696	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
243365000697	active site residue [active]
243365000698	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
243365000699	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365000700	S-adenosylmethionine binding site [chemical binding]; other site
243365000701	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
243365000702	ThiC-associated domain; Region: ThiC-associated; pfam13667
243365000703	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
243365000704	Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326
243365000705	SpoOM protein; Region: Spo0M; pfam07070
243365000706	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
243365000707	Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide,  which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068
243365000708	heme-binding site [chemical binding]; other site
243365000709	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365000710	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365000711	metal binding site [ion binding]; metal-binding site
243365000712	active site
243365000713	I-site; other site
243365000714	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365000715	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365000716	metal binding site [ion binding]; metal-binding site
243365000717	active site
243365000718	I-site; other site
243365000719	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
243365000720	active site
243365000721	phosphorylation site [posttranslational modification]
243365000722	EthD domain; Region: EthD; cl17553
243365000723	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
243365000724	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
243365000725	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
243365000726	dimer interface [polypeptide binding]; other site
243365000727	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
243365000728	metal binding site [ion binding]; metal-binding site
243365000729	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
243365000730	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243365000731	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243365000732	substrate binding pocket [chemical binding]; other site
243365000733	membrane-bound complex binding site; other site
243365000734	hinge residues; other site
243365000735	pyruvate kinase; Provisional; Region: PRK06247
243365000736	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
243365000737	domain interfaces; other site
243365000738	active site
243365000739	glycerol kinase; Provisional; Region: glpK; PRK00047
243365000740	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
243365000741	N- and C-terminal domain interface [polypeptide binding]; other site
243365000742	active site
243365000743	MgATP binding site [chemical binding]; other site
243365000744	catalytic site [active]
243365000745	metal binding site [ion binding]; metal-binding site
243365000746	glycerol binding site [chemical binding]; other site
243365000747	homotetramer interface [polypeptide binding]; other site
243365000748	homodimer interface [polypeptide binding]; other site
243365000749	FBP binding site [chemical binding]; other site
243365000750	protein IIAGlc interface [polypeptide binding]; other site
243365000751	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
243365000752	amphipathic channel; other site
243365000753	Asn-Pro-Ala signature motifs; other site
243365000754	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
243365000755	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365000756	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365000757	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
243365000758	Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; pfam03543
243365000759	B3/4 domain; Region: B3_4; smart00873
243365000760	B3/4 domain; Region: B3_4; pfam03483
243365000761	HAMP domain; Region: HAMP; pfam00672
243365000762	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243365000763	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365000764	dimer interface [polypeptide binding]; other site
243365000765	putative CheW interface [polypeptide binding]; other site
243365000766	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
243365000767	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
243365000768	Walker A/P-loop; other site
243365000769	ATP binding site [chemical binding]; other site
243365000770	Q-loop/lid; other site
243365000771	ABC transporter signature motif; other site
243365000772	Walker B; other site
243365000773	D-loop; other site
243365000774	H-loop/switch region; other site
243365000775	TOBE domain; Region: TOBE_2; pfam08402
243365000776	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
243365000777	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
243365000778	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
243365000779	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365000780	dimer interface [polypeptide binding]; other site
243365000781	conserved gate region; other site
243365000782	putative PBP binding loops; other site
243365000783	ABC-ATPase subunit interface; other site
243365000784	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365000785	putative PBP binding loops; other site
243365000786	dimer interface [polypeptide binding]; other site
243365000787	ABC-ATPase subunit interface; other site
243365000788	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
243365000789	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
243365000790	outer membrane porin, OprD family; Region: OprD; pfam03573
243365000791	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
243365000792	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
243365000793	HAMP domain; Region: HAMP; pfam00672
243365000794	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365000795	dimer interface [polypeptide binding]; other site
243365000796	putative CheW interface [polypeptide binding]; other site
243365000797	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
243365000798	Peptidase family U32; Region: Peptidase_U32; pfam01136
243365000799	Collagenase; Region: DUF3656; pfam12392
243365000800	MAPEG family; Region: MAPEG; cl09190
243365000801	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365000802	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365000803	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
243365000804	putative substrate binding pocket [chemical binding]; other site
243365000805	putative dimerization interface [polypeptide binding]; other site
243365000806	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
243365000807	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
243365000808	Helix-turn-helix domain; Region: HTH_18; pfam12833
243365000809	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
243365000810	homotrimer interaction site [polypeptide binding]; other site
243365000811	putative active site [active]
243365000812	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
243365000813	SnoaL-like domain; Region: SnoaL_2; pfam12680
243365000814	topology modulation protein; Reviewed; Region: PRK08118
243365000815	AAA domain; Region: AAA_17; pfam13207
243365000816	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
243365000817	Protein of unknown function, DUF606; Region: DUF606; pfam04657
243365000818	Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436
243365000819	LTXXQ motif family protein; Region: LTXXQ; pfam07813
243365000820	Protein of unknown function (DUF3141); Region: DUF3141; pfam11339
243365000821	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
243365000822	Domain of unknown function (DUF4337); Region: DUF4337; pfam14235
243365000823	glutathionine S-transferase; Provisional; Region: PRK10542
243365000824	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
243365000825	C-terminal domain interface [polypeptide binding]; other site
243365000826	GSH binding site (G-site) [chemical binding]; other site
243365000827	dimer interface [polypeptide binding]; other site
243365000828	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
243365000829	dimer interface [polypeptide binding]; other site
243365000830	N-terminal domain interface [polypeptide binding]; other site
243365000831	substrate binding pocket (H-site) [chemical binding]; other site
243365000832	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
243365000833	Predicted transcriptional regulators [Transcription]; Region: COG1733
243365000834	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
243365000835	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
243365000836	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
243365000837	active site
243365000838	metal binding site [ion binding]; metal-binding site
243365000839	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
243365000840	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
243365000841	homodimer interface [polypeptide binding]; other site
243365000842	chemical substrate binding site [chemical binding]; other site
243365000843	oligomer interface [polypeptide binding]; other site
243365000844	metal binding site [ion binding]; metal-binding site
243365000845	NAD-dependent deacetylase; Provisional; Region: PRK00481
243365000846	SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413
243365000847	NAD+ binding site [chemical binding]; other site
243365000848	substrate binding site [chemical binding]; other site
243365000849	Zn binding site [ion binding]; other site
243365000850	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
243365000851	Mechanosensitive ion channel; Region: MS_channel; pfam00924
243365000852	SopE GEF domain; Region: SopE_GEF; pfam07487
243365000853	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
243365000854	putative NAD(P) binding site [chemical binding]; other site
243365000855	homodimer interface [polypeptide binding]; other site
243365000856	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365000857	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365000858	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
243365000859	dimerization interface [polypeptide binding]; other site
243365000860	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
243365000861	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365000862	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
243365000863	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
243365000864	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
243365000865	dimer interface [polypeptide binding]; other site
243365000866	PYR/PP interface [polypeptide binding]; other site
243365000867	TPP binding site [chemical binding]; other site
243365000868	substrate binding site [chemical binding]; other site
243365000869	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
243365000870	TPP-binding site [chemical binding]; other site
243365000871	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
243365000872	Predicted permeases [General function prediction only]; Region: RarD; COG2962
243365000873	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
243365000874	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
243365000875	DNA binding residues [nucleotide binding]
243365000876	dimerization interface [polypeptide binding]; other site
243365000877	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
243365000878	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
243365000879	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
243365000880	HlyD family secretion protein; Region: HlyD_3; pfam13437
243365000881	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421
243365000882	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
243365000883	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
243365000884	ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245
243365000885	Walker A/P-loop; other site
243365000886	ATP binding site [chemical binding]; other site
243365000887	Q-loop/lid; other site
243365000888	ABC transporter signature motif; other site
243365000889	Walker B; other site
243365000890	D-loop; other site
243365000891	H-loop/switch region; other site
243365000892	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
243365000893	Predicted transglutaminase-like cysteine proteinase [General    function prediction only]; Region: COG3672
243365000894	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365000895	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365000896	metal binding site [ion binding]; metal-binding site
243365000897	active site
243365000898	I-site; other site
243365000899	EAL domain; Region: EAL; pfam00563
243365000900	VCBS repeat; Region: VCBS_repeat; TIGR01965
243365000901	VCBS repeat; Region: VCBS_repeat; TIGR01965
243365000902	VCBS repeat; Region: VCBS_repeat; TIGR01965
243365000903	VCBS repeat; Region: VCBS_repeat; TIGR01965
243365000904	VCBS repeat; Region: VCBS_repeat; TIGR01965
243365000905	VCBS repeat; Region: VCBS_repeat; TIGR01965
243365000906	VCBS repeat; Region: VCBS_repeat; TIGR01965
243365000907	VCBS repeat; Region: VCBS_repeat; TIGR01965
243365000908	VCBS repeat; Region: VCBS_repeat; TIGR01965
243365000909	VCBS repeat; Region: VCBS_repeat; TIGR01965
243365000910	VCBS repeat; Region: VCBS_repeat; TIGR01965
243365000911	VCBS repeat; Region: VCBS_repeat; TIGR01965
243365000912	VCBS repeat; Region: VCBS_repeat; TIGR01965
243365000913	VCBS repeat; Region: VCBS_repeat; TIGR01965
243365000914	VCBS repeat; Region: VCBS_repeat; TIGR01965
243365000915	VCBS repeat; Region: VCBS_repeat; TIGR01965
243365000916	VCBS repeat; Region: VCBS_repeat; TIGR01965
243365000917	VCBS repeat; Region: VCBS_repeat; TIGR01965
243365000918	VCBS repeat; Region: VCBS_repeat; TIGR01965
243365000919	VCBS repeat; Region: VCBS_repeat; TIGR01965
243365000920	VCBS repeat; Region: VCBS_repeat; TIGR01965
243365000921	VCBS repeat; Region: VCBS_repeat; TIGR01965
243365000922	VCBS repeat; Region: VCBS_repeat; TIGR01965
243365000923	VCBS repeat; Region: VCBS_repeat; TIGR01965
243365000924	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
243365000925	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
243365000926	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
243365000927	Peptidase M3-like family, a zincin metallopeptidase, includes M3 and M32 families; Region: M3_like; cd06258
243365000928	active site
243365000929	Zn binding site [ion binding]; other site
243365000930	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
243365000931	N-terminal domain interface [polypeptide binding]; other site
243365000932	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
243365000933	active site
243365000934	phosphate binding residues; other site
243365000935	catalytic residues [active]
243365000936	Protein of unknown function (DUF962); Region: DUF962; cl01879
243365000937	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
243365000938	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
243365000939	DNA-binding site [nucleotide binding]; DNA binding site
243365000940	UTRA domain; Region: UTRA; pfam07702
243365000941	imidazolonepropionase; Validated; Region: PRK09356
243365000942	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
243365000943	active site
243365000944	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
243365000945	putative active site [active]
243365000946	putative metal binding site [ion binding]; other site
243365000947	urocanate hydratase; Provisional; Region: PRK05414
243365000948	Lipocalin-like domain; Region: Lipocalin_5; pfam13924
243365000949	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
243365000950	active sites [active]
243365000951	tetramer interface [polypeptide binding]; other site
243365000952	Uncharacterized conserved protein [Function unknown]; Region: COG1262
243365000953	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
243365000954	Transposase IS200 like; Region: Y1_Tnp; cl00848
243365000955	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365000956	Coenzyme A binding pocket [chemical binding]; other site
243365000957	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
243365000958	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
243365000959	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365000960	homodimer interface [polypeptide binding]; other site
243365000961	catalytic residue [active]
243365000962	Superinfection immunity protein; Region: Imm_superinfect; pfam14373
243365000963	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365000964	Coenzyme A binding pocket [chemical binding]; other site
243365000965	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365000966	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
243365000967	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
243365000968	EamA-like transporter family; Region: EamA; pfam00892
243365000969	Phage Tail Collar Domain; Region: Collar; pfam07484
243365000970	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
243365000971	Phage Tail Collar Domain; Region: Collar; pfam07484
243365000972	Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076
243365000973	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
243365000974	Phage protein GP46; Region: GP46; cl01814
243365000975	Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410
243365000976	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
243365000977	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
243365000978	Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228
243365000979	DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157
243365000980	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
243365000981	N-acetyl-D-glucosamine binding site [chemical binding]; other site
243365000982	catalytic residue [active]
243365000983	Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386
243365000984	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
243365000985	Phage tail sheath protein; Region: Phage_sheath_1; pfam04984
243365000986	Domain of unknown function (DUF1834); Region: DUF1834; pfam08873
243365000987	phage/conjugal plasmid C-4 type zinc finger protein, TraR family; Region: C4_traR_proteo; TIGR02419
243365000988	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
243365000989	Mor transcription activator family; Region: Mor; cl02360
243365000990	Predicted transcriptional regulator [Transcription]; Region: COG2932
243365000991	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
243365000992	Catalytic site [active]
243365000993	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
243365000994	active site
243365000995	dimer interface [polypeptide binding]; other site
243365000996	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
243365000997	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
243365000998	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
243365000999	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
243365001000	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243365001001	Zn2+ binding site [ion binding]; other site
243365001002	Mg2+ binding site [ion binding]; other site
243365001003	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
243365001004	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
243365001005	active site
243365001006	catalytic triad [active]
243365001007	oxyanion hole [active]
243365001008	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
243365001009	S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672
243365001010	putative RNA binding site [nucleotide binding]; other site
243365001011	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
243365001012	active site
243365001013	catalytic triad [active]
243365001014	oxyanion hole [active]
243365001015	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
243365001016	Restriction alleviation protein Lar; Region: Lar_restr_allev; cl08047
243365001017	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
243365001018	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
243365001019	transmembrane helices; other site
243365001020	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
243365001021	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
243365001022	active site
243365001023	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
243365001024	RNA methyltransferase, RsmE family; Region: TIGR00046
243365001025	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
243365001026	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
243365001027	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243365001028	Zn2+ binding site [ion binding]; other site
243365001029	Mg2+ binding site [ion binding]; other site
243365001030	Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540
243365001031	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
243365001032	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
243365001033	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
243365001034	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
243365001035	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
243365001036	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
243365001037	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365001038	Coenzyme A binding pocket [chemical binding]; other site
243365001039	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
243365001040	putative metal binding site [ion binding]; other site
243365001041	Uncharacterized conserved protein [Function unknown]; Region: COG1432
243365001042	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
243365001043	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
243365001044	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
243365001045	substrate binding pocket [chemical binding]; other site
243365001046	membrane-bound complex binding site; other site
243365001047	hinge residues; other site
243365001048	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
243365001049	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
243365001050	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
243365001051	putative ligand binding site [chemical binding]; other site
243365001052	Serine hydrolase; Region: Ser_hydrolase; pfam06821
243365001053	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
243365001054	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
243365001055	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
243365001056	YaeQ protein; Region: YaeQ; pfam07152
243365001057	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
243365001058	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
243365001059	helicase 45; Provisional; Region: PTZ00424
243365001060	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
243365001061	ATP binding site [chemical binding]; other site
243365001062	Mg++ binding site [ion binding]; other site
243365001063	motif III; other site
243365001064	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243365001065	nucleotide binding region [chemical binding]; other site
243365001066	ATP-binding site [chemical binding]; other site
243365001067	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243365001068	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243365001069	substrate binding pocket [chemical binding]; other site
243365001070	membrane-bound complex binding site; other site
243365001071	hinge residues; other site
243365001072	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243365001073	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
243365001074	PAS domain; Region: PAS; smart00091
243365001075	PAS domain; Region: PAS_9; pfam13426
243365001076	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365001077	putative active site [active]
243365001078	heme pocket [chemical binding]; other site
243365001079	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365001080	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365001081	metal binding site [ion binding]; metal-binding site
243365001082	active site
243365001083	I-site; other site
243365001084	PAS domain S-box; Region: sensory_box; TIGR00229
243365001085	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365001086	putative active site [active]
243365001087	heme pocket [chemical binding]; other site
243365001088	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365001089	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365001090	metal binding site [ion binding]; metal-binding site
243365001091	active site
243365001092	I-site; other site
243365001093	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
243365001094	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
243365001095	RNA binding surface [nucleotide binding]; other site
243365001096	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
243365001097	active site
243365001098	uracil binding [chemical binding]; other site
243365001099	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
243365001100	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
243365001101	tetramer interface [polypeptide binding]; other site
243365001102	active site
243365001103	Mg2+/Mn2+ binding site [ion binding]; other site
243365001104	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
243365001105	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
243365001106	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
243365001107	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
243365001108	DNA binding site [nucleotide binding]
243365001109	active site
243365001110	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
243365001111	GAF domain; Region: GAF; pfam01590
243365001112	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243365001113	Walker A motif; other site
243365001114	ATP binding site [chemical binding]; other site
243365001115	Walker B motif; other site
243365001116	arginine finger; other site
243365001117	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
243365001118	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
243365001119	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
243365001120	NAD(P) binding site [chemical binding]; other site
243365001121	catalytic residues [active]
243365001122	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365001123	S-adenosylmethionine binding site [chemical binding]; other site
243365001124	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365001125	dimer interface [polypeptide binding]; other site
243365001126	putative CheW interface [polypeptide binding]; other site
243365001127	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365001128	PAS domain; Region: PAS_9; pfam13426
243365001129	putative active site [active]
243365001130	heme pocket [chemical binding]; other site
243365001131	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
243365001132	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
243365001133	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
243365001134	Transglutaminase/protease-like homologues; Region: TGc; smart00460
243365001135	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
243365001136	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
243365001137	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
243365001138	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
243365001139	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
243365001140	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
243365001141	active site
243365001142	HslU subunit interaction site [polypeptide binding]; other site
243365001143	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
243365001144	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243365001145	Walker A motif; other site
243365001146	ATP binding site [chemical binding]; other site
243365001147	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
243365001148	Walker B motif; other site
243365001149	arginine finger; other site
243365001150	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
243365001151	H+ Antiporter protein; Region: 2A0121; TIGR00900
243365001152	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365001153	putative substrate translocation pore; other site
243365001154	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
243365001155	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
243365001156	dimerization interface [polypeptide binding]; other site
243365001157	ligand binding site [chemical binding]; other site
243365001158	Mor transcription activator family; Region: Mor; pfam08765
243365001159	Gp37 protein; Region: Gp37; pfam09646
243365001160	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
243365001161	Phage tail tube protein FII; Region: Phage_tube; cl01390
243365001162	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
243365001163	Phage P2 GpU; Region: Phage_P2_GpU; pfam06995
243365001164	Phage Tail Protein X; Region: Phage_tail_X; cl02088
243365001165	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
243365001166	Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812
243365001167	Phage-related tail fibre protein [General function prediction only]; Region: COG5301
243365001168	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
243365001169	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
243365001170	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
243365001171	Baseplate J-like protein; Region: Baseplate_J; cl01294
243365001172	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684
243365001173	Phage-related tail fibre protein [General function prediction only]; Region: COG5301
243365001174	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
243365001175	Phage-related tail fibre protein [General function prediction only]; Region: COG5301
243365001176	Phage-related tail fibre protein [General function prediction only]; Region: COG5301
243365001177	Phage-related tail fibre protein [General function prediction only]; Region: COG5301
243365001178	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
243365001179	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
243365001180	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
243365001181	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
243365001182	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
243365001183	HlyD family secretion protein; Region: HlyD_3; pfam13437
243365001184	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243365001185	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
243365001186	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
243365001187	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
243365001188	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
243365001189	Walker A/P-loop; other site
243365001190	ATP binding site [chemical binding]; other site
243365001191	Q-loop/lid; other site
243365001192	ABC transporter signature motif; other site
243365001193	Walker B; other site
243365001194	D-loop; other site
243365001195	H-loop/switch region; other site
243365001196	ABC-2 type transporter; Region: ABC2_membrane; cl17235
243365001197	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
243365001198	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
243365001199	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
243365001200	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
243365001201	hinge; other site
243365001202	active site
243365001203	Patatin-like phospholipase; Region: Pat17_PNPLA8_PNPLA9_like1; cd07213
243365001204	active site
243365001205	nucleophile elbow; other site
243365001206	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
243365001207	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
243365001208	PhnA protein; Region: PhnA; pfam03831
243365001209	VacJ like lipoprotein; Region: VacJ; cl01073
243365001210	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
243365001211	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
243365001212	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
243365001213	mce related protein; Region: MCE; pfam02470
243365001214	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
243365001215	Permease; Region: Permease; pfam02405
243365001216	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
243365001217	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
243365001218	Walker A/P-loop; other site
243365001219	ATP binding site [chemical binding]; other site
243365001220	Q-loop/lid; other site
243365001221	ABC transporter signature motif; other site
243365001222	Walker B; other site
243365001223	D-loop; other site
243365001224	H-loop/switch region; other site
243365001225	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
243365001226	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
243365001227	trimer interface [polypeptide binding]; other site
243365001228	active site
243365001229	substrate binding site [chemical binding]; other site
243365001230	CoA binding site [chemical binding]; other site
243365001231	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
243365001232	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
243365001233	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365001234	homodimer interface [polypeptide binding]; other site
243365001235	catalytic residue [active]
243365001236	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
243365001237	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
243365001238	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365001239	Coenzyme A binding pocket [chemical binding]; other site
243365001240	hypothetical protein; Provisional; Region: PRK04325
243365001241	Predicted permease [General function prediction only]; Region: COG2056
243365001242	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
243365001243	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
243365001244	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
243365001245	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
243365001246	dimerization interface [polypeptide binding]; other site
243365001247	putative DNA binding site [nucleotide binding]; other site
243365001248	putative Zn2+ binding site [ion binding]; other site
243365001249	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
243365001250	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
243365001251	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365001252	S-adenosylmethionine binding site [chemical binding]; other site
243365001253	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
243365001254	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
243365001255	Outer membrane efflux protein; Region: OEP; pfam02321
243365001256	Outer membrane efflux protein; Region: OEP; pfam02321
243365001257	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
243365001258	HlyD family secretion protein; Region: HlyD_3; pfam13437
243365001259	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
243365001260	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365001261	Coenzyme A binding pocket [chemical binding]; other site
243365001262	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
243365001263	Phage Tail Collar Domain; Region: Collar; pfam07484
243365001264	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
243365001265	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
243365001266	Competence protein; Region: Competence; pfam03772
243365001267	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
243365001268	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
243365001269	Response regulator receiver domain; Region: Response_reg; pfam00072
243365001270	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365001271	active site
243365001272	phosphorylation site [posttranslational modification]
243365001273	intermolecular recognition site; other site
243365001274	dimerization interface [polypeptide binding]; other site
243365001275	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
243365001276	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
243365001277	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243365001278	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243365001279	dimer interface [polypeptide binding]; other site
243365001280	phosphorylation site [posttranslational modification]
243365001281	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365001282	ATP binding site [chemical binding]; other site
243365001283	Mg2+ binding site [ion binding]; other site
243365001284	G-X-G motif; other site
243365001285	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
243365001286	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
243365001287	P-loop; other site
243365001288	Magnesium ion binding site [ion binding]; other site
243365001289	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
243365001290	Magnesium ion binding site [ion binding]; other site
243365001291	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
243365001292	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
243365001293	ATP binding site [chemical binding]; other site
243365001294	putative Mg++ binding site [ion binding]; other site
243365001295	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243365001296	nucleotide binding region [chemical binding]; other site
243365001297	ATP-binding site [chemical binding]; other site
243365001298	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
243365001299	HRDC domain; Region: HRDC; pfam00570
243365001300	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
243365001301	heterotetramer interface [polypeptide binding]; other site
243365001302	active site pocket [active]
243365001303	cleavage site
243365001304	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
243365001305	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
243365001306	Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726
243365001307	PilX N-terminal; Region: PilX_N; pfam14341
243365001308	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
243365001309	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
243365001310	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
243365001311	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
243365001312	Type II transport protein GspH; Region: GspH; pfam12019
243365001313	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
243365001314	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
243365001315	active site
243365001316	nucleotide binding site [chemical binding]; other site
243365001317	HIGH motif; other site
243365001318	KMSKS motif; other site
243365001319	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
243365001320	Biotin operon repressor [Transcription]; Region: BirA; COG1654
243365001321	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
243365001322	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
243365001323	Type III pantothenate kinase; Region: Pan_kinase; cl17198
243365001324	Sporulation related domain; Region: SPOR; pfam05036
243365001325	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
243365001326	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
243365001327	agmatinase; Region: agmatinase; TIGR01230
243365001328	oligomer interface [polypeptide binding]; other site
243365001329	putative active site [active]
243365001330	Mn binding site [ion binding]; other site
243365001331	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
243365001332	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
243365001333	catalytic core [active]
243365001334	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
243365001335	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
243365001336	putative dimer interface [polypeptide binding]; other site
243365001337	active site pocket [active]
243365001338	putative cataytic base [active]
243365001339	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
243365001340	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
243365001341	N-terminal plug; other site
243365001342	ligand-binding site [chemical binding]; other site
243365001343	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
243365001344	homotrimer interface [polypeptide binding]; other site
243365001345	Walker A motif; other site
243365001346	GTP binding site [chemical binding]; other site
243365001347	Walker B motif; other site
243365001348	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
243365001349	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
243365001350	cobalamin binding residues [chemical binding]; other site
243365001351	putative BtuC binding residues; other site
243365001352	dimer interface [polypeptide binding]; other site
243365001353	Cell division protein ZapA; Region: ZapA; pfam05164
243365001354	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
243365001355	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
243365001356	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
243365001357	EVE domain; Region: EVE; cl00728
243365001358	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
243365001359	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
243365001360	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
243365001361	HIGH motif; other site
243365001362	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
243365001363	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
243365001364	active site
243365001365	KMSKS motif; other site
243365001366	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
243365001367	tRNA binding surface [nucleotide binding]; other site
243365001368	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
243365001369	Lipopolysaccharide-assembly; Region: LptE; cl01125
243365001370	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
243365001371	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
243365001372	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
243365001373	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
243365001374	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365001375	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365001376	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476
243365001377	putative effector binding pocket; other site
243365001378	putative dimerization interface [polypeptide binding]; other site
243365001379	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
243365001380	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365001381	Major Facilitator Superfamily; Region: MFS_1; pfam07690
243365001382	putative substrate translocation pore; other site
243365001383	A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases.  Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417
243365001384	type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846
243365001385	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
243365001386	ATP-binding cassette domain of hemolysin B, subfamily C; Region: ABCC_Hemolysin; cd03252
243365001387	Walker A/P-loop; other site
243365001388	ATP binding site [chemical binding]; other site
243365001389	Q-loop/lid; other site
243365001390	ABC transporter signature motif; other site
243365001391	Walker B; other site
243365001392	D-loop; other site
243365001393	H-loop/switch region; other site
243365001394	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
243365001395	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
243365001396	HlyD family secretion protein; Region: HlyD_3; pfam13437
243365001397	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
243365001398	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
243365001399	putative ADP-binding pocket [chemical binding]; other site
243365001400	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
243365001401	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
243365001402	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
243365001403	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
243365001404	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
243365001405	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
243365001406	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
243365001407	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
243365001408	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
243365001409	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
243365001410	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
243365001411	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
243365001412	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
243365001413	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
243365001414	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
243365001415	active site
243365001416	(T/H)XGH motif; other site
243365001417	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
243365001418	active site clefts [active]
243365001419	zinc binding site [ion binding]; other site
243365001420	dimer interface [polypeptide binding]; other site
243365001421	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
243365001422	Protein of unknown function (DUF2804); Region: DUF2804; pfam10974
243365001423	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
243365001424	Peptidase family M48; Region: Peptidase_M48; cl12018
243365001425	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
243365001426	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
243365001427	dimer interface [polypeptide binding]; other site
243365001428	TPP-binding site [chemical binding]; other site
243365001429	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
243365001430	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
243365001431	E3 interaction surface; other site
243365001432	lipoyl attachment site [posttranslational modification]; other site
243365001433	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
243365001434	E3 interaction surface; other site
243365001435	lipoyl attachment site [posttranslational modification]; other site
243365001436	e3 binding domain; Region: E3_binding; pfam02817
243365001437	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
243365001438	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
243365001439	E3 interaction surface; other site
243365001440	lipoyl attachment site [posttranslational modification]; other site
243365001441	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
243365001442	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
243365001443	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
243365001444	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
243365001445	Predicted flavoprotein [General function prediction only]; Region: COG0431
243365001446	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
243365001447	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365001448	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365001449	metal binding site [ion binding]; metal-binding site
243365001450	active site
243365001451	I-site; other site
243365001452	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
243365001453	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365001454	Coenzyme A binding pocket [chemical binding]; other site
243365001455	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
243365001456	Surface antigen; Region: Bac_surface_Ag; pfam01103
243365001457	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
243365001458	Family of unknown function (DUF490); Region: DUF490; pfam04357
243365001459	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
243365001460	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243365001461	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243365001462	dimer interface [polypeptide binding]; other site
243365001463	phosphorylation site [posttranslational modification]
243365001464	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365001465	ATP binding site [chemical binding]; other site
243365001466	Mg2+ binding site [ion binding]; other site
243365001467	G-X-G motif; other site
243365001468	BetR domain; Region: BetR; pfam08667
243365001469	Response regulator receiver domain; Region: Response_reg; pfam00072
243365001470	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365001471	active site
243365001472	phosphorylation site [posttranslational modification]
243365001473	intermolecular recognition site; other site
243365001474	MarR family; Region: MarR; pfam01047
243365001475	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
243365001476	Isochorismatase family; Region: Isochorismatase; pfam00857
243365001477	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
243365001478	catalytic triad [active]
243365001479	conserved cis-peptide bond; other site
243365001480	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365001481	PAS domain; Region: PAS_9; pfam13426
243365001482	putative active site [active]
243365001483	heme pocket [chemical binding]; other site
243365001484	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365001485	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365001486	metal binding site [ion binding]; metal-binding site
243365001487	active site
243365001488	I-site; other site
243365001489	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243365001490	tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415
243365001491	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
243365001492	FMN binding site [chemical binding]; other site
243365001493	active site
243365001494	catalytic residues [active]
243365001495	substrate binding site [chemical binding]; other site
243365001496	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
243365001497	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
243365001498	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
243365001499	purine monophosphate binding site [chemical binding]; other site
243365001500	dimer interface [polypeptide binding]; other site
243365001501	putative catalytic residues [active]
243365001502	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
243365001503	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
243365001504	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
243365001505	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
243365001506	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
243365001507	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
243365001508	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
243365001509	TolQ protein; Region: tolQ; TIGR02796
243365001510	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
243365001511	EamA-like transporter family; Region: EamA; pfam00892
243365001512	EamA-like transporter family; Region: EamA; pfam00892
243365001513	Chitin binding domain; Region: Chitin_bind_3; pfam03067
243365001514	Chitin binding domain; Region: Chitin_bind_3; pfam03067
243365001515	chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214
243365001516	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
243365001517	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
243365001518	DNA-binding site [nucleotide binding]; DNA binding site
243365001519	UTRA domain; Region: UTRA; pfam07702
243365001520	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
243365001521	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
243365001522	active site
243365001523	dimer interface [polypeptide binding]; other site
243365001524	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
243365001525	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
243365001526	dimer interface [polypeptide binding]; other site
243365001527	active site
243365001528	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
243365001529	dimer interface [polypeptide binding]; other site
243365001530	active site
243365001531	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
243365001532	HPr interaction site; other site
243365001533	glycerol kinase (GK) interaction site [polypeptide binding]; other site
243365001534	active site
243365001535	phosphorylation site [posttranslational modification]
243365001536	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
243365001537	dimerization domain swap beta strand [polypeptide binding]; other site
243365001538	regulatory protein interface [polypeptide binding]; other site
243365001539	active site
243365001540	regulatory phosphorylation site [posttranslational modification]; other site
243365001541	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
243365001542	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
243365001543	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
243365001544	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
243365001545	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
243365001546	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
243365001547	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
243365001548	active site turn [active]
243365001549	phosphorylation site [posttranslational modification]
243365001550	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
243365001551	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
243365001552	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
243365001553	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
243365001554	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
243365001555	putative DNA binding site [nucleotide binding]; other site
243365001556	putative Zn2+ binding site [ion binding]; other site
243365001557	AsnC family; Region: AsnC_trans_reg; pfam01037
243365001558	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
243365001559	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365001560	active site
243365001561	phosphorylation site [posttranslational modification]
243365001562	intermolecular recognition site; other site
243365001563	dimerization interface [polypeptide binding]; other site
243365001564	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
243365001565	DNA binding site [nucleotide binding]
243365001566	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
243365001567	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
243365001568	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365001569	putative active site [active]
243365001570	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243365001571	dimer interface [polypeptide binding]; other site
243365001572	phosphorylation site [posttranslational modification]
243365001573	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365001574	ATP binding site [chemical binding]; other site
243365001575	Mg2+ binding site [ion binding]; other site
243365001576	G-X-G motif; other site
243365001577	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
243365001578	putative active site [active]
243365001579	transaldolase; Provisional; Region: PRK03903
243365001580	catalytic residue [active]
243365001581	Hemerythrin-like domain; Region: Hr-like; cd12108
243365001582	Fe binding site [ion binding]; other site
243365001583	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
243365001584	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
243365001585	amidase catalytic site [active]
243365001586	Zn binding residues [ion binding]; other site
243365001587	substrate binding site [chemical binding]; other site
243365001588	aminodeoxychorismate synthase; Provisional; Region: PRK07508
243365001589	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
243365001590	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
243365001591	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
243365001592	salt bridge; other site
243365001593	sequence-specific DNA binding site [nucleotide binding]; other site
243365001594	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
243365001595	potassium uptake protein; Region: kup; TIGR00794
243365001596	prolyl-tRNA synthetase; Provisional; Region: PRK09194
243365001597	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
243365001598	dimer interface [polypeptide binding]; other site
243365001599	motif 1; other site
243365001600	active site
243365001601	motif 2; other site
243365001602	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
243365001603	putative deacylase active site [active]
243365001604	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
243365001605	active site
243365001606	motif 3; other site
243365001607	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
243365001608	anticodon binding site; other site
243365001609	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
243365001610	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
243365001611	N-acetyl-D-glucosamine binding site [chemical binding]; other site
243365001612	catalytic residue [active]
243365001613	manganese transport protein MntH; Reviewed; Region: PRK00701
243365001614	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
243365001615	MarR family; Region: MarR_2; cl17246
243365001616	guanine deaminase; Provisional; Region: PRK09228
243365001617	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
243365001618	active site
243365001619	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
243365001620	Uncharacterized conserved protein [Function unknown]; Region: COG2128
243365001621	Protein of unknown function (DUF2798); Region: DUF2798; pfam11391
243365001622	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365001623	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365001624	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
243365001625	putative effector binding pocket; other site
243365001626	dimerization interface [polypeptide binding]; other site
243365001627	RDD family; Region: RDD; pfam06271
243365001628	Protein of unknown function (DUF3106); Region: DUF3106; pfam11304
243365001629	RNA polymerase factor sigma-70; Validated; Region: PRK09047
243365001630	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
243365001631	DNA binding residues [nucleotide binding]
243365001632	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965
243365001633	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
243365001634	PYR/PP interface [polypeptide binding]; other site
243365001635	dimer interface [polypeptide binding]; other site
243365001636	TPP binding site [chemical binding]; other site
243365001637	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
243365001638	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
243365001639	TPP-binding site [chemical binding]; other site
243365001640	dimer interface [polypeptide binding]; other site
243365001641	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
243365001642	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
243365001643	putative valine binding site [chemical binding]; other site
243365001644	dimer interface [polypeptide binding]; other site
243365001645	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
243365001646	ketol-acid reductoisomerase; Provisional; Region: PRK05479
243365001647	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
243365001648	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
243365001649	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
243365001650	Protein of unknown function (DUF2860); Region: DUF2860; pfam11059
243365001651	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
243365001652	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
243365001653	DNA binding site [nucleotide binding]
243365001654	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243365001655	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365001656	ATP binding site [chemical binding]; other site
243365001657	Mg2+ binding site [ion binding]; other site
243365001658	G-X-G motif; other site
243365001659	2-isopropylmalate synthase; Validated; Region: PRK00915
243365001660	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
243365001661	active site
243365001662	catalytic residues [active]
243365001663	metal binding site [ion binding]; metal-binding site
243365001664	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
243365001665	cardiolipin synthetase; Reviewed; Region: PRK12452
243365001666	AAA domain; Region: AAA_26; pfam13500
243365001667	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
243365001668	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140
243365001669	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
243365001670	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
243365001671	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
243365001672	Cytochrome c; Region: Cytochrom_C; pfam00034
243365001673	cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007
243365001674	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
243365001675	Subunit I/III interface [polypeptide binding]; other site
243365001676	D-pathway; other site
243365001677	Subunit I/VIIc interface [polypeptide binding]; other site
243365001678	Subunit I/IV interface [polypeptide binding]; other site
243365001679	Subunit I/II interface [polypeptide binding]; other site
243365001680	Low-spin heme (heme a) binding site [chemical binding]; other site
243365001681	Subunit I/VIIa interface [polypeptide binding]; other site
243365001682	Subunit I/VIa interface [polypeptide binding]; other site
243365001683	Dimer interface; other site
243365001684	Putative water exit pathway; other site
243365001685	Binuclear center (heme a3/CuB) [ion binding]; other site
243365001686	K-pathway; other site
243365001687	Subunit I/Vb interface [polypeptide binding]; other site
243365001688	Putative proton exit pathway; other site
243365001689	Subunit I/VIb interface; other site
243365001690	Subunit I/VIc interface [polypeptide binding]; other site
243365001691	Electron transfer pathway; other site
243365001692	Subunit I/VIIIb interface [polypeptide binding]; other site
243365001693	Subunit I/VIIb interface [polypeptide binding]; other site
243365001694	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
243365001695	Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
243365001696	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
243365001697	Subunit III/VIIa interface [polypeptide binding]; other site
243365001698	Phospholipid binding site [chemical binding]; other site
243365001699	Subunit I/III interface [polypeptide binding]; other site
243365001700	Subunit III/VIb interface [polypeptide binding]; other site
243365001701	Subunit III/VIa interface; other site
243365001702	Subunit III/Vb interface [polypeptide binding]; other site
243365001703	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cl01321
243365001704	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
243365001705	active site
243365001706	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
243365001707	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
243365001708	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
243365001709	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
243365001710	Cu(I) binding site [ion binding]; other site
243365001711	Flagellar regulator YcgR; Region: YcgR; pfam07317
243365001712	PilZ domain; Region: PilZ; pfam07238
243365001713	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
243365001714	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
243365001715	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
243365001716	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
243365001717	NAD binding site [chemical binding]; other site
243365001718	dimerization interface [polypeptide binding]; other site
243365001719	product binding site; other site
243365001720	substrate binding site [chemical binding]; other site
243365001721	zinc binding site [ion binding]; other site
243365001722	catalytic residues [active]
243365001723	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
243365001724	intersubunit interface [polypeptide binding]; other site
243365001725	histidinol-phosphate aminotransferase; Provisional; Region: PRK04870
243365001726	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
243365001727	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365001728	homodimer interface [polypeptide binding]; other site
243365001729	catalytic residue [active]
243365001730	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
243365001731	putative active site pocket [active]
243365001732	4-fold oligomerization interface [polypeptide binding]; other site
243365001733	metal binding residues [ion binding]; metal-binding site
243365001734	3-fold/trimer interface [polypeptide binding]; other site
243365001735	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
243365001736	putative dimer interface [polypeptide binding]; other site
243365001737	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
243365001738	ligand binding site [chemical binding]; other site
243365001739	Zn binding site [ion binding]; other site
243365001740	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
243365001741	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
243365001742	putative active site [active]
243365001743	oxyanion strand; other site
243365001744	catalytic triad [active]
243365001745	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
243365001746	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
243365001747	catalytic residues [active]
243365001748	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
243365001749	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
243365001750	substrate binding site [chemical binding]; other site
243365001751	glutamase interaction surface [polypeptide binding]; other site
243365001752	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
243365001753	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
243365001754	metal binding site [ion binding]; metal-binding site
243365001755	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
243365001756	nucleotide binding site/active site [active]
243365001757	HIT family signature motif; other site
243365001758	catalytic residue [active]
243365001759	twin arginine translocase protein A; Provisional; Region: tatA; PRK02958
243365001760	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
243365001761	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
243365001762	Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842
243365001763	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
243365001764	HAMP domain; Region: HAMP; pfam00672
243365001765	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365001766	dimer interface [polypeptide binding]; other site
243365001767	putative CheW interface [polypeptide binding]; other site
243365001768	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
243365001769	active site
243365001770	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
243365001771	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
243365001772	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243365001773	Walker A/P-loop; other site
243365001774	ATP binding site [chemical binding]; other site
243365001775	Q-loop/lid; other site
243365001776	ABC transporter signature motif; other site
243365001777	Walker B; other site
243365001778	D-loop; other site
243365001779	H-loop/switch region; other site
243365001780	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
243365001781	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
243365001782	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243365001783	Walker A/P-loop; other site
243365001784	ATP binding site [chemical binding]; other site
243365001785	Q-loop/lid; other site
243365001786	ABC transporter signature motif; other site
243365001787	Walker B; other site
243365001788	D-loop; other site
243365001789	H-loop/switch region; other site
243365001790	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
243365001791	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
243365001792	PAS fold; Region: PAS_4; pfam08448
243365001793	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
243365001794	DNA binding residues [nucleotide binding]
243365001795	dimerization interface [polypeptide binding]; other site
243365001796	AAA domain; Region: AAA_23; pfam13476
243365001797	AAA domain; Region: AAA_21; pfam13304
243365001798	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243365001799	Walker B; other site
243365001800	D-loop; other site
243365001801	H-loop/switch region; other site
243365001802	DNA primase domain-containing protein; Region: PHA02415
243365001803	CHC2 zinc finger; Region: zf-CHC2; cl17510
243365001804	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188
243365001805	active site
243365001806	metal binding site [ion binding]; metal-binding site
243365001807	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
243365001808	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
243365001809	Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947
243365001810	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
243365001811	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930
243365001812	HNH endonuclease; Region: HNH_5; pfam14279
243365001813	integrase; Provisional; Region: PRK09692
243365001814	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
243365001815	active site
243365001816	Int/Topo IB signature motif; other site
243365001817	Predicted methyltransferases [General function prediction only]; Region: COG0313
243365001818	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
243365001819	putative SAM binding site [chemical binding]; other site
243365001820	putative homodimer interface [polypeptide binding]; other site
243365001821	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
243365001822	putative ligand binding site [chemical binding]; other site
243365001823	hypothetical protein; Reviewed; Region: PRK12497
243365001824	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
243365001825	dimer interface [polypeptide binding]; other site
243365001826	active site
243365001827	BON domain; Region: BON; pfam04972
243365001828	BON domain; Region: BON; pfam04972
243365001829	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243365001830	Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978
243365001831	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
243365001832	homodimer interaction site [polypeptide binding]; other site
243365001833	cofactor binding site; other site
243365001834	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
243365001835	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
243365001836	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
243365001837	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
243365001838	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
243365001839	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365001840	S-adenosylmethionine binding site [chemical binding]; other site
243365001841	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
243365001842	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
243365001843	P-loop; other site
243365001844	Magnesium ion binding site [ion binding]; other site
243365001845	transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345
243365001846	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
243365001847	Magnesium ion binding site [ion binding]; other site
243365001848	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
243365001849	ParB-like nuclease domain; Region: ParBc; pfam02195
243365001850	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
243365001851	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
243365001852	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
243365001853	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
243365001854	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
243365001855	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
243365001856	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
243365001857	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
243365001858	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
243365001859	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
243365001860	beta subunit interaction interface [polypeptide binding]; other site
243365001861	Walker A motif; other site
243365001862	ATP binding site [chemical binding]; other site
243365001863	Walker B motif; other site
243365001864	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
243365001865	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
243365001866	core domain interface [polypeptide binding]; other site
243365001867	delta subunit interface [polypeptide binding]; other site
243365001868	epsilon subunit interface [polypeptide binding]; other site
243365001869	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
243365001870	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
243365001871	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
243365001872	alpha subunit interaction interface [polypeptide binding]; other site
243365001873	Walker A motif; other site
243365001874	ATP binding site [chemical binding]; other site
243365001875	Walker B motif; other site
243365001876	inhibitor binding site; inhibition site
243365001877	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
243365001878	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
243365001879	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
243365001880	gamma subunit interface [polypeptide binding]; other site
243365001881	epsilon subunit interface [polypeptide binding]; other site
243365001882	LBP interface [polypeptide binding]; other site
243365001883	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
243365001884	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
243365001885	Substrate binding site; other site
243365001886	Mg++ binding site; other site
243365001887	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
243365001888	active site
243365001889	substrate binding site [chemical binding]; other site
243365001890	CoA binding site [chemical binding]; other site
243365001891	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994
243365001892	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
243365001893	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
243365001894	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
243365001895	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
243365001896	glutaminase active site [active]
243365001897	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
243365001898	dimer interface [polypeptide binding]; other site
243365001899	active site
243365001900	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
243365001901	dimer interface [polypeptide binding]; other site
243365001902	active site
243365001903	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
243365001904	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
243365001905	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
243365001906	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423
243365001907	putative active site [active]
243365001908	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
243365001909	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243365001910	Walker A motif; other site
243365001911	ATP binding site [chemical binding]; other site
243365001912	Walker B motif; other site
243365001913	arginine finger; other site
243365001914	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
243365001915	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
243365001916	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
243365001917	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
243365001918	putative NADP binding site [chemical binding]; other site
243365001919	putative substrate binding site [chemical binding]; other site
243365001920	active site
243365001921	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
243365001922	DNA binding residues [nucleotide binding]
243365001923	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
243365001924	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365001925	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365001926	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
243365001927	putative substrate binding pocket [chemical binding]; other site
243365001928	putative dimerization interface [polypeptide binding]; other site
243365001929	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
243365001930	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
243365001931	Patatin phospholipase; Region: DUF3734; pfam12536
243365001932	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394
243365001933	classical (c) SDRs; Region: SDR_c; cd05233
243365001934	NAD(P) binding site [chemical binding]; other site
243365001935	active site
243365001936	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
243365001937	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365001938	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
243365001939	dimerization interface [polypeptide binding]; other site
243365001940	substrate binding pocket [chemical binding]; other site
243365001941	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
243365001942	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
243365001943	GDP-binding site [chemical binding]; other site
243365001944	ACT binding site; other site
243365001945	IMP binding site; other site
243365001946	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
243365001947	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243365001948	substrate binding pocket [chemical binding]; other site
243365001949	membrane-bound complex binding site; other site
243365001950	hinge residues; other site
243365001951	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365001952	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365001953	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478
243365001954	putative effector binding pocket; other site
243365001955	dimerization interface [polypeptide binding]; other site
243365001956	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
243365001957	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365001958	putative substrate translocation pore; other site
243365001959	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
243365001960	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
243365001961	active site
243365001962	catalytic tetrad [active]
243365001963	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
243365001964	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
243365001965	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
243365001966	AzlC protein; Region: AzlC; cl00570
243365001967	Predicted membrane protein [Function unknown]; Region: COG4392
243365001968	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
243365001969	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
243365001970	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365001971	putative substrate translocation pore; other site
243365001972	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
243365001973	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
243365001974	HlyD family secretion protein; Region: HlyD_3; pfam13437
243365001975	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
243365001976	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243365001977	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
243365001978	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
243365001979	DinB family; Region: DinB; cl17821
243365001980	DinB superfamily; Region: DinB_2; pfam12867
243365001981	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243365001982	dimerization interface [polypeptide binding]; other site
243365001983	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243365001984	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365001985	dimer interface [polypeptide binding]; other site
243365001986	putative CheW interface [polypeptide binding]; other site
243365001987	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
243365001988	NADH(P)-binding; Region: NAD_binding_10; pfam13460
243365001989	NAD binding site [chemical binding]; other site
243365001990	substrate binding site [chemical binding]; other site
243365001991	putative active site [active]
243365001992	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365001993	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365001994	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
243365001995	putative effector binding pocket; other site
243365001996	dimerization interface [polypeptide binding]; other site
243365001997	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365001998	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365001999	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
243365002000	putative effector binding pocket; other site
243365002001	dimerization interface [polypeptide binding]; other site
243365002002	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
243365002003	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365002004	putative substrate translocation pore; other site
243365002005	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365002006	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365002007	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
243365002008	putative effector binding pocket; other site
243365002009	dimerization interface [polypeptide binding]; other site
243365002010	Killing trait; Region: RebB; pfam11747
243365002011	Killing trait; Region: RebB; pfam11747
243365002012	Killing trait; Region: RebB; pfam11747
243365002013	Killing trait; Region: RebB; pfam11747
243365002014	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
243365002015	catalytic residues [active]
243365002016	Esterase PHB depolymerase; Region: Esterase_phd; pfam10503
243365002017	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
243365002018	active site
243365002019	nucleophile elbow; other site
243365002020	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
243365002021	Killing trait; Region: RebB; pfam11747
243365002022	Protein of unknown function (DUF4239); Region: DUF4239; pfam14023
243365002023	Protein of unknown function (DUF2589); Region: DUF2589; pfam11655
243365002024	Protein of unknown function (DUF2589); Region: DUF2589; pfam11655
243365002025	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
243365002026	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
243365002027	DNA binding residues [nucleotide binding]
243365002028	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
243365002029	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
243365002030	ligand binding site [chemical binding]; other site
243365002031	flexible hinge region; other site
243365002032	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
243365002033	S-formylglutathione hydrolase; Region: PLN02442
243365002034	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
243365002035	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
243365002036	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
243365002037	substrate binding site [chemical binding]; other site
243365002038	catalytic Zn binding site [ion binding]; other site
243365002039	NAD binding site [chemical binding]; other site
243365002040	structural Zn binding site [ion binding]; other site
243365002041	dimer interface [polypeptide binding]; other site
243365002042	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365002043	LysR family transcriptional regulator; Provisional; Region: PRK14997
243365002044	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470
243365002045	putative effector binding pocket; other site
243365002046	putative dimerization interface [polypeptide binding]; other site
243365002047	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
243365002048	Protein of unknown function (DUF805); Region: DUF805; pfam05656
243365002049	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
243365002050	Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939
243365002051	putative active site [active]
243365002052	putative catalytic site [active]
243365002053	putative Zn binding site [ion binding]; other site
243365002054	LabA_like proteins; Region: LabA_like; cd06167
243365002055	putative metal binding site [ion binding]; other site
243365002056	Uncharacterized conserved protein [Function unknown]; Region: COG1432
243365002057	NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908
243365002058	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
243365002059	NAD binding site [chemical binding]; other site
243365002060	substrate binding site [chemical binding]; other site
243365002061	active site
243365002062	putative formyltransferase; Provisional; Region: PRK06988
243365002063	ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644
243365002064	substrate binding site [chemical binding]; other site
243365002065	cosubstrate binding site; other site
243365002066	catalytic site [active]
243365002067	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
243365002068	active site
243365002069	hexamer interface [polypeptide binding]; other site
243365002070	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
243365002071	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
243365002072	Ligand binding site; other site
243365002073	Putative Catalytic site; other site
243365002074	DXD motif; other site
243365002075	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
243365002076	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
243365002077	inhibitor-cofactor binding pocket; inhibition site
243365002078	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365002079	catalytic residue [active]
243365002080	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
243365002081	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
243365002082	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
243365002083	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
243365002084	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
243365002085	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
243365002086	Esterase/lipase [General function prediction only]; Region: COG1647
243365002087	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
243365002088	sensor protein RstB; Provisional; Region: PRK10604
243365002089	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243365002090	dimer interface [polypeptide binding]; other site
243365002091	phosphorylation site [posttranslational modification]
243365002092	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365002093	ATP binding site [chemical binding]; other site
243365002094	Mg2+ binding site [ion binding]; other site
243365002095	G-X-G motif; other site
243365002096	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
243365002097	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365002098	active site
243365002099	phosphorylation site [posttranslational modification]
243365002100	intermolecular recognition site; other site
243365002101	dimerization interface [polypeptide binding]; other site
243365002102	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
243365002103	DNA binding site [nucleotide binding]
243365002104	carbon starvation protein A; Provisional; Region: PRK15015
243365002105	Carbon starvation protein CstA; Region: CstA; pfam02554
243365002106	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
243365002107	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
243365002108	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
243365002109	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365002110	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
243365002111	putative dimerization interface [polypeptide binding]; other site
243365002112	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365002113	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
243365002114	putative substrate translocation pore; other site
243365002115	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365002116	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
243365002117	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
243365002118	HlyD family secretion protein; Region: HlyD_3; pfam13437
243365002119	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
243365002120	MarR family; Region: MarR_2; cl17246
243365002121	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
243365002122	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
243365002123	ArsC family; Region: ArsC; pfam03960
243365002124	catalytic residues [active]
243365002125	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
243365002126	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365002127	putative substrate translocation pore; other site
243365002128	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
243365002129	Chain length determinant protein; Region: Wzz; pfam02706
243365002130	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
243365002131	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
243365002132	SLBB domain; Region: SLBB; pfam10531
243365002133	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
243365002134	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
243365002135	active site
243365002136	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
243365002137	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
243365002138	putative active site [active]
243365002139	putative substrate binding site [chemical binding]; other site
243365002140	ATP binding site [chemical binding]; other site
243365002141	Protein of unknown function (DUF2782); Region: DUF2782; pfam11191
243365002142	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
243365002143	DNA polymerase I; Provisional; Region: PRK05755
243365002144	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
243365002145	active site
243365002146	metal binding site 1 [ion binding]; metal-binding site
243365002147	putative 5' ssDNA interaction site; other site
243365002148	metal binding site 3; metal-binding site
243365002149	metal binding site 2 [ion binding]; metal-binding site
243365002150	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
243365002151	putative DNA binding site [nucleotide binding]; other site
243365002152	putative metal binding site [ion binding]; other site
243365002153	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
243365002154	active site
243365002155	catalytic site [active]
243365002156	substrate binding site [chemical binding]; other site
243365002157	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
243365002158	active site
243365002159	DNA binding site [nucleotide binding]
243365002160	catalytic site [active]
243365002161	Type II transport protein GspH; Region: GspH; pfam12019
243365002162	Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726
243365002163	muropeptide transporter; Reviewed; Region: ampG; PRK11902
243365002164	AmpG-like permease; Region: 2A0125; TIGR00901
243365002165	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365002166	S-adenosylmethionine binding site [chemical binding]; other site
243365002167	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
243365002168	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
243365002169	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
243365002170	TMAO/DMSO reductase; Reviewed; Region: PRK05363
243365002171	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
243365002172	Moco binding site; other site
243365002173	metal coordination site [ion binding]; other site
243365002174	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
243365002175	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
243365002176	putative deacylase active site [active]
243365002177	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243365002178	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243365002179	substrate binding pocket [chemical binding]; other site
243365002180	membrane-bound complex binding site; other site
243365002181	hinge residues; other site
243365002182	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
243365002183	4Fe-4S binding domain; Region: Fer4_5; pfam12801
243365002184	Iron permease FTR1 family; Region: FTR1; cl00475
243365002185	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
243365002186	Fe2+ transport protein; Region: Iron_transport; pfam10634
243365002187	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
243365002188	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
243365002189	active site
243365002190	dimer interface [polypeptide binding]; other site
243365002191	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
243365002192	Ligand Binding Site [chemical binding]; other site
243365002193	Molecular Tunnel; other site
243365002194	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365002195	Major Facilitator Superfamily; Region: MFS_1; pfam07690
243365002196	putative substrate translocation pore; other site
243365002197	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
243365002198	Helix-turn-helix domain; Region: HTH_18; pfam12833
243365002199	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
243365002200	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
243365002201	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
243365002202	peptide binding site [polypeptide binding]; other site
243365002203	H+ Antiporter protein; Region: 2A0121; TIGR00900
243365002204	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
243365002205	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
243365002206	substrate-cofactor binding pocket; other site
243365002207	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365002208	catalytic residue [active]
243365002209	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
243365002210	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
243365002211	active site
243365002212	iron coordination sites [ion binding]; other site
243365002213	substrate binding pocket [chemical binding]; other site
243365002214	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
243365002215	dimer interface [polypeptide binding]; other site
243365002216	active site
243365002217	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
243365002218	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
243365002219	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
243365002220	AMP binding site [chemical binding]; other site
243365002221	active site
243365002222	acyl-activating enzyme (AAE) consensus motif; other site
243365002223	CoA binding site [chemical binding]; other site
243365002224	Prostaglandin dehydrogenases; Region: PGDH; cd05288
243365002225	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
243365002226	NAD(P) binding site [chemical binding]; other site
243365002227	substrate binding site [chemical binding]; other site
243365002228	dimer interface [polypeptide binding]; other site
243365002229	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
243365002230	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
243365002231	ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214
243365002232	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
243365002233	Protein of unknown function (DUF3025); Region: DUF3025; pfam11227
243365002234	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
243365002235	GAF domain; Region: GAF; pfam01590
243365002236	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365002237	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365002238	metal binding site [ion binding]; metal-binding site
243365002239	active site
243365002240	I-site; other site
243365002241	siroheme synthase; Provisional; Region: cysG; PRK10637
243365002242	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
243365002243	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
243365002244	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
243365002245	active site
243365002246	SAM binding site [chemical binding]; other site
243365002247	homodimer interface [polypeptide binding]; other site
243365002248	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
243365002249	active pocket/dimerization site; other site
243365002250	active site
243365002251	phosphorylation site [posttranslational modification]
243365002252	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
243365002253	dimerization domain swap beta strand [polypeptide binding]; other site
243365002254	regulatory protein interface [polypeptide binding]; other site
243365002255	active site
243365002256	regulatory phosphorylation site [posttranslational modification]; other site
243365002257	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
243365002258	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
243365002259	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
243365002260	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
243365002261	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
243365002262	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
243365002263	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
243365002264	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
243365002265	active site
243365002266	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
243365002267	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
243365002268	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
243365002269	putative NAD(P) binding site [chemical binding]; other site
243365002270	active site
243365002271	putative substrate binding site [chemical binding]; other site
243365002272	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
243365002273	O-Antigen ligase; Region: Wzy_C; pfam04932
243365002274	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
243365002275	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
243365002276	putative ADP-binding pocket [chemical binding]; other site
243365002277	lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422
243365002278	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
243365002279	putative active site [active]
243365002280	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
243365002281	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
243365002282	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
243365002283	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
243365002284	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
243365002285	Walker A/P-loop; other site
243365002286	ATP binding site [chemical binding]; other site
243365002287	Q-loop/lid; other site
243365002288	ABC transporter signature motif; other site
243365002289	Walker B; other site
243365002290	D-loop; other site
243365002291	H-loop/switch region; other site
243365002292	Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170
243365002293	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
243365002294	active site
243365002295	dimer interface [polypeptide binding]; other site
243365002296	metal binding site [ion binding]; metal-binding site
243365002297	shikimate kinase; Reviewed; Region: aroK; PRK00131
243365002298	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
243365002299	ADP binding site [chemical binding]; other site
243365002300	magnesium binding site [ion binding]; other site
243365002301	putative shikimate binding site; other site
243365002302	AMIN domain; Region: AMIN; pfam11741
243365002303	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
243365002304	Secretin and TonB N terminus short domain; Region: STN; smart00965
243365002305	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
243365002306	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
243365002307	Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168
243365002308	Pilus assembly protein, PilP; Region: PilP; pfam04351
243365002309	Pilus assembly protein, PilO; Region: PilO; pfam04350
243365002310	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
243365002311	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
243365002312	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
243365002313	Competence protein A; Region: Competence_A; pfam11104
243365002314	nucleotide binding site [chemical binding]; other site
243365002315	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
243365002316	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
243365002317	Transglycosylase; Region: Transgly; pfam00912
243365002318	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
243365002319	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
243365002320	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
243365002321	active site
243365002322	metal binding site [ion binding]; metal-binding site
243365002323	hexamer interface [polypeptide binding]; other site
243365002324	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
243365002325	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
243365002326	Autotransporter beta-domain; Region: Autotransporter; pfam03797
243365002327	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365002328	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365002329	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
243365002330	putative dimerization interface [polypeptide binding]; other site
243365002331	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365002332	PAS domain; Region: PAS_9; pfam13426
243365002333	putative active site [active]
243365002334	heme pocket [chemical binding]; other site
243365002335	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365002336	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365002337	metal binding site [ion binding]; metal-binding site
243365002338	active site
243365002339	I-site; other site
243365002340	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243365002341	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
243365002342	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
243365002343	substrate binding pocket [chemical binding]; other site
243365002344	chain length determination region; other site
243365002345	substrate-Mg2+ binding site; other site
243365002346	catalytic residues [active]
243365002347	aspartate-rich region 1; other site
243365002348	active site lid residues [active]
243365002349	aspartate-rich region 2; other site
243365002350	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
243365002351	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
243365002352	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
243365002353	GTPase CgtA; Reviewed; Region: obgE; PRK12299
243365002354	GTP1/OBG; Region: GTP1_OBG; pfam01018
243365002355	Obg GTPase; Region: Obg; cd01898
243365002356	G1 box; other site
243365002357	GTP/Mg2+ binding site [chemical binding]; other site
243365002358	Switch I region; other site
243365002359	G2 box; other site
243365002360	G3 box; other site
243365002361	Switch II region; other site
243365002362	G4 box; other site
243365002363	G5 box; other site
243365002364	ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010
243365002365	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243365002366	substrate binding pocket [chemical binding]; other site
243365002367	membrane-bound complex binding site; other site
243365002368	hinge residues; other site
243365002369	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
243365002370	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365002371	dimer interface [polypeptide binding]; other site
243365002372	conserved gate region; other site
243365002373	putative PBP binding loops; other site
243365002374	ABC-ATPase subunit interface; other site
243365002375	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
243365002376	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365002377	dimer interface [polypeptide binding]; other site
243365002378	conserved gate region; other site
243365002379	putative PBP binding loops; other site
243365002380	ABC-ATPase subunit interface; other site
243365002381	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
243365002382	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
243365002383	Walker A/P-loop; other site
243365002384	ATP binding site [chemical binding]; other site
243365002385	Q-loop/lid; other site
243365002386	ABC transporter signature motif; other site
243365002387	Walker B; other site
243365002388	D-loop; other site
243365002389	H-loop/switch region; other site
243365002390	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
243365002391	Domain of unknown function (DUF333); Region: DUF333; pfam03891
243365002392	Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816
243365002393	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250
243365002394	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
243365002395	active site
243365002396	Zn binding site [ion binding]; other site
243365002397	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
243365002398	AAA domain; Region: AAA_23; pfam13476
243365002399	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243365002400	AAA domain; Region: AAA_21; pfam13304
243365002401	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243365002402	ABC transporter signature motif; other site
243365002403	Walker B; other site
243365002404	D-loop; other site
243365002405	H-loop/switch region; other site
243365002406	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
243365002407	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
243365002408	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
243365002409	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
243365002410	Alpha/beta hydrolase of unknown function (DUF1100); Region: DUF1100; pfam06500
243365002411	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
243365002412	MarR family; Region: MarR_2; pfam12802
243365002413	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
243365002414	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
243365002415	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
243365002416	Domain of unknown function (DUF1842); Region: DUF1842; pfam08896
243365002417	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
243365002418	dimer interface [polypeptide binding]; other site
243365002419	catalytic triad [active]
243365002420	peroxidatic and resolving cysteines [active]
243365002421	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
243365002422	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
243365002423	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365002424	putative CheW interface [polypeptide binding]; other site
243365002425	RDD family; Region: RDD; pfam06271
243365002426	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
243365002427	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
243365002428	trimer interface [polypeptide binding]; other site
243365002429	putative metal binding site [ion binding]; other site
243365002430	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
243365002431	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
243365002432	active site
243365002433	Zn binding site [ion binding]; other site
243365002434	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
243365002435	putative catalytic site [active]
243365002436	putative phosphate binding site [ion binding]; other site
243365002437	active site
243365002438	metal binding site A [ion binding]; metal-binding site
243365002439	DNA binding site [nucleotide binding]
243365002440	putative AP binding site [nucleotide binding]; other site
243365002441	putative metal binding site B [ion binding]; other site
243365002442	Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide,  which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068
243365002443	heme-binding site [chemical binding]; other site
243365002444	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
243365002445	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
243365002446	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
243365002447	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
243365002448	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243365002449	dimer interface [polypeptide binding]; other site
243365002450	phosphorylation site [posttranslational modification]
243365002451	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365002452	ATP binding site [chemical binding]; other site
243365002453	Mg2+ binding site [ion binding]; other site
243365002454	G-X-G motif; other site
243365002455	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365002456	Response regulator receiver domain; Region: Response_reg; pfam00072
243365002457	active site
243365002458	phosphorylation site [posttranslational modification]
243365002459	intermolecular recognition site; other site
243365002460	dimerization interface [polypeptide binding]; other site
243365002461	Response regulator receiver domain; Region: Response_reg; pfam00072
243365002462	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365002463	active site
243365002464	phosphorylation site [posttranslational modification]
243365002465	intermolecular recognition site; other site
243365002466	dimerization interface [polypeptide binding]; other site
243365002467	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365002468	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
243365002469	active site
243365002470	phosphorylation site [posttranslational modification]
243365002471	intermolecular recognition site; other site
243365002472	dimerization interface [polypeptide binding]; other site
243365002473	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243365002474	Zn2+ binding site [ion binding]; other site
243365002475	Mg2+ binding site [ion binding]; other site
243365002476	Methyltransferase domain; Region: Methyltransf_31; pfam13847
243365002477	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
243365002478	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
243365002479	FAD binding pocket [chemical binding]; other site
243365002480	FAD binding motif [chemical binding]; other site
243365002481	phosphate binding motif [ion binding]; other site
243365002482	beta-alpha-beta structure motif; other site
243365002483	NAD binding pocket [chemical binding]; other site
243365002484	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
243365002485	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
243365002486	DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336
243365002487	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365002488	active site
243365002489	phosphorylation site [posttranslational modification]
243365002490	intermolecular recognition site; other site
243365002491	dimerization interface [polypeptide binding]; other site
243365002492	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
243365002493	DNA binding site [nucleotide binding]
243365002494	sensor protein QseC; Provisional; Region: PRK10337
243365002495	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243365002496	dimer interface [polypeptide binding]; other site
243365002497	phosphorylation site [posttranslational modification]
243365002498	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365002499	ATP binding site [chemical binding]; other site
243365002500	Mg2+ binding site [ion binding]; other site
243365002501	G-X-G motif; other site
243365002502	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
243365002503	putative substrate binding pocket [chemical binding]; other site
243365002504	trimer interface [polypeptide binding]; other site
243365002505	lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983
243365002506	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
243365002507	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
243365002508	N-terminal plug; other site
243365002509	ligand-binding site [chemical binding]; other site
243365002510	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243365002511	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
243365002512	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
243365002513	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365002514	active site
243365002515	phosphorylation site [posttranslational modification]
243365002516	intermolecular recognition site; other site
243365002517	dimerization interface [polypeptide binding]; other site
243365002518	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
243365002519	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
243365002520	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
243365002521	dimer interface [polypeptide binding]; other site
243365002522	acyl-activating enzyme (AAE) consensus motif; other site
243365002523	putative active site [active]
243365002524	AMP binding site [chemical binding]; other site
243365002525	putative CoA binding site [chemical binding]; other site
243365002526	Cache domain; Region: Cache_1; pfam02743
243365002527	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243365002528	dimerization interface [polypeptide binding]; other site
243365002529	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243365002530	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365002531	dimer interface [polypeptide binding]; other site
243365002532	putative CheW interface [polypeptide binding]; other site
243365002533	TPR repeat; Region: TPR_11; pfam13414
243365002534	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243365002535	binding surface
243365002536	TPR motif; other site
243365002537	Tetratricopeptide repeat; Region: TPR_12; pfam13424
243365002538	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243365002539	binding surface
243365002540	TPR motif; other site
243365002541	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
243365002542	TPR motif; other site
243365002543	binding surface
243365002544	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
243365002545	FAD binding domain; Region: FAD_binding_4; pfam01565
243365002546	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
243365002547	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837
243365002548	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
243365002549	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
243365002550	putative C-terminal domain interface [polypeptide binding]; other site
243365002551	putative GSH binding site (G-site) [chemical binding]; other site
243365002552	putative dimer interface [polypeptide binding]; other site
243365002553	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
243365002554	N-terminal domain interface [polypeptide binding]; other site
243365002555	dimer interface [polypeptide binding]; other site
243365002556	substrate binding pocket (H-site) [chemical binding]; other site
243365002557	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
243365002558	Na binding site [ion binding]; other site
243365002559	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
243365002560	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365002561	Coenzyme A binding pocket [chemical binding]; other site
243365002562	phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396
243365002563	Phosphoesterase family; Region: Phosphoesterase; pfam04185
243365002564	Domain of unknown function (DUF756); Region: DUF756; pfam05506
243365002565	Domain of unknown function (DUF756); Region: DUF756; pfam05506
243365002566	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
243365002567	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
243365002568	non-specific DNA binding site [nucleotide binding]; other site
243365002569	salt bridge; other site
243365002570	sequence-specific DNA binding site [nucleotide binding]; other site
243365002571	2TM domain; Region: 2TM; pfam13239
243365002572	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
243365002573	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
243365002574	putative active site [active]
243365002575	putative PHP Thumb interface [polypeptide binding]; other site
243365002576	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
243365002577	generic binding surface II; other site
243365002578	generic binding surface I; other site
243365002579	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
243365002580	Protein of unknown function (DUF535); Region: DUF535; pfam04393
243365002581	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
243365002582	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
243365002583	Malic enzyme, N-terminal domain; Region: malic; pfam00390
243365002584	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
243365002585	putative NAD(P) binding site [chemical binding]; other site
243365002586	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
243365002587	TRAP transporter, DctM subunit; Region: dctM; TIGR00786
243365002588	DctM-like transporters; Region: DctM; pfam06808
243365002589	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
243365002590	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
243365002591	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
243365002592	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365002593	PAS domain; Region: PAS_9; pfam13426
243365002594	putative active site [active]
243365002595	heme pocket [chemical binding]; other site
243365002596	PAS domain; Region: PAS_8; pfam13188
243365002597	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243365002598	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243365002599	dimer interface [polypeptide binding]; other site
243365002600	phosphorylation site [posttranslational modification]
243365002601	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365002602	ATP binding site [chemical binding]; other site
243365002603	Mg2+ binding site [ion binding]; other site
243365002604	G-X-G motif; other site
243365002605	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
243365002606	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
243365002607	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
243365002608	Chromate transporter; Region: Chromate_transp; pfam02417
243365002609	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
243365002610	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
243365002611	FMN binding site [chemical binding]; other site
243365002612	active site
243365002613	catalytic residues [active]
243365002614	substrate binding site [chemical binding]; other site
243365002615	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
243365002616	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
243365002617	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
243365002618	active site
243365002619	dimerization interface [polypeptide binding]; other site
243365002620	coproporphyrinogen III oxidase; Provisional; Region: PRK08898
243365002621	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243365002622	FeS/SAM binding site; other site
243365002623	HemN C-terminal domain; Region: HemN_C; pfam06969
243365002624	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
243365002625	homotrimer interaction site [polypeptide binding]; other site
243365002626	putative active site [active]
243365002627	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
243365002628	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
243365002629	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
243365002630	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
243365002631	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
243365002632	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
243365002633	ssDNA binding site; other site
243365002634	generic binding surface II; other site
243365002635	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
243365002636	ATP binding site [chemical binding]; other site
243365002637	putative Mg++ binding site [ion binding]; other site
243365002638	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243365002639	nucleotide binding region [chemical binding]; other site
243365002640	ATP-binding site [chemical binding]; other site
243365002641	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
243365002642	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
243365002643	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
243365002644	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
243365002645	Walker A/P-loop; other site
243365002646	ATP binding site [chemical binding]; other site
243365002647	Q-loop/lid; other site
243365002648	ABC transporter signature motif; other site
243365002649	Walker B; other site
243365002650	D-loop; other site
243365002651	H-loop/switch region; other site
243365002652	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
243365002653	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365002654	dimer interface [polypeptide binding]; other site
243365002655	conserved gate region; other site
243365002656	putative PBP binding loops; other site
243365002657	ABC-ATPase subunit interface; other site
243365002658	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
243365002659	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365002660	dimer interface [polypeptide binding]; other site
243365002661	conserved gate region; other site
243365002662	putative PBP binding loops; other site
243365002663	ABC-ATPase subunit interface; other site
243365002664	PBP superfamily domain; Region: PBP_like_2; cl17296
243365002665	triosephosphate isomerase; Provisional; Region: PRK14567
243365002666	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
243365002667	substrate binding site [chemical binding]; other site
243365002668	dimer interface [polypeptide binding]; other site
243365002669	catalytic triad [active]
243365002670	Preprotein translocase SecG subunit; Region: SecG; pfam03840
243365002671	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
243365002672	NADH dehydrogenase subunit B; Validated; Region: PRK06411
243365002673	NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; COG0852
243365002674	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
243365002675	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
243365002676	NADH dehydrogenase subunit D; Validated; Region: PRK06075
243365002677	NADH dehydrogenase subunit E; Validated; Region: PRK07539
243365002678	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
243365002679	putative dimer interface [polypeptide binding]; other site
243365002680	[2Fe-2S] cluster binding site [ion binding]; other site
243365002681	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
243365002682	SLBB domain; Region: SLBB; pfam10531
243365002683	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
243365002684	NADH dehydrogenase subunit G; Validated; Region: PRK09129
243365002685	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
243365002686	catalytic loop [active]
243365002687	iron binding site [ion binding]; other site
243365002688	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
243365002689	MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772
243365002690	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
243365002691	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
243365002692	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
243365002693	4Fe-4S binding domain; Region: Fer4; cl02805
243365002694	4Fe-4S binding domain; Region: Fer4; pfam00037
243365002695	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
243365002696	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
243365002697	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
243365002698	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
243365002699	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
243365002700	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
243365002701	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
243365002702	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
243365002703	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
243365002704	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
243365002705	Protein of unknown function (DUF2818); Region: DUF2818; pfam10993
243365002706	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
243365002707	B1 nucleotide binding pocket [chemical binding]; other site
243365002708	B2 nucleotide binding pocket [chemical binding]; other site
243365002709	CAS motifs; other site
243365002710	active site
243365002711	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
243365002712	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
243365002713	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
243365002714	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
243365002715	B1 nucleotide binding pocket [chemical binding]; other site
243365002716	B2 nucleotide binding pocket [chemical binding]; other site
243365002717	CAS motifs; other site
243365002718	active site
243365002719	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
243365002720	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
243365002721	putative acyl-acceptor binding pocket; other site
243365002722	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
243365002723	putative acyl-acceptor binding pocket; other site
243365002724	S-adenosylmethionine synthetase; Validated; Region: PRK05250
243365002725	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
243365002726	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
243365002727	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
243365002728	PAS fold; Region: PAS_4; pfam08448
243365002729	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365002730	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365002731	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365002732	metal binding site [ion binding]; metal-binding site
243365002733	active site
243365002734	I-site; other site
243365002735	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
243365002736	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
243365002737	homotetramer interface [polypeptide binding]; other site
243365002738	ligand binding site [chemical binding]; other site
243365002739	catalytic site [active]
243365002740	NAD binding site [chemical binding]; other site
243365002741	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
243365002742	FAD binding site [chemical binding]; other site
243365002743	hypothetical protein; Provisional; Region: PRK05208
243365002744	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
243365002745	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
243365002746	putative DNA binding site [nucleotide binding]; other site
243365002747	putative Zn2+ binding site [ion binding]; other site
243365002748	AsnC family; Region: AsnC_trans_reg; pfam01037
243365002749	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
243365002750	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
243365002751	dimer interface [polypeptide binding]; other site
243365002752	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
243365002753	active site
243365002754	Fe binding site [ion binding]; other site
243365002755	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
243365002756	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
243365002757	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
243365002758	maleylacetoacetate isomerase; Region: maiA; TIGR01262
243365002759	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
243365002760	C-terminal domain interface [polypeptide binding]; other site
243365002761	GSH binding site (G-site) [chemical binding]; other site
243365002762	putative dimer interface [polypeptide binding]; other site
243365002763	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
243365002764	dimer interface [polypeptide binding]; other site
243365002765	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
243365002766	N-terminal domain interface [polypeptide binding]; other site
243365002767	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
243365002768	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365002769	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
243365002770	Protein-tyrosine phosphatase; Region: Y_phosphatase; pfam00102
243365002771	active site
243365002772	Tir chaperone protein (CesT) family; Region: CesT; pfam05932
243365002773	bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507
243365002774	putative hydrolase; Provisional; Region: PRK10976
243365002775	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243365002776	active site
243365002777	motif I; other site
243365002778	motif II; other site
243365002779	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
243365002780	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
243365002781	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365002782	S-adenosylmethionine binding site [chemical binding]; other site
243365002783	PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089
243365002784	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
243365002785	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
243365002786	active site turn [active]
243365002787	phosphorylation site [posttranslational modification]
243365002788	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
243365002789	HPr interaction site; other site
243365002790	glycerol kinase (GK) interaction site [polypeptide binding]; other site
243365002791	active site
243365002792	phosphorylation site [posttranslational modification]
243365002793	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
243365002794	dimerization domain swap beta strand [polypeptide binding]; other site
243365002795	regulatory protein interface [polypeptide binding]; other site
243365002796	active site
243365002797	regulatory phosphorylation site [posttranslational modification]; other site
243365002798	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
243365002799	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
243365002800	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
243365002801	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
243365002802	DoxX; Region: DoxX; pfam07681
243365002803	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365002804	LysR family transcriptional regulator; Provisional; Region: PRK14997
243365002805	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
243365002806	putative effector binding pocket; other site
243365002807	dimerization interface [polypeptide binding]; other site
243365002808	MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098
243365002809	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
243365002810	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
243365002811	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365002812	S-adenosylmethionine binding site [chemical binding]; other site
243365002813	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
243365002814	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
243365002815	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
243365002816	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
243365002817	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
243365002818	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
243365002819	carboxyltransferase (CT) interaction site; other site
243365002820	biotinylation site [posttranslational modification]; other site
243365002821	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
243365002822	Dehydroquinase class II; Region: DHquinase_II; pfam01220
243365002823	trimer interface [polypeptide binding]; other site
243365002824	active site
243365002825	dimer interface [polypeptide binding]; other site
243365002826	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
243365002827	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
243365002828	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
243365002829	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365002830	S-adenosylmethionine binding site [chemical binding]; other site
243365002831	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
243365002832	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
243365002833	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
243365002834	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
243365002835	benzoate transport; Region: 2A0115; TIGR00895
243365002836	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365002837	putative substrate translocation pore; other site
243365002838	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365002839	Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560
243365002840	aminotransferase AlaT; Validated; Region: PRK09265
243365002841	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
243365002842	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365002843	homodimer interface [polypeptide binding]; other site
243365002844	catalytic residue [active]
243365002845	homoserine dehydrogenase; Provisional; Region: PRK06349
243365002846	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
243365002847	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
243365002848	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
243365002849	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
243365002850	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
243365002851	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365002852	catalytic residue [active]
243365002853	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
243365002854	Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847
243365002855	active site
243365002856	oxyanion hole [active]
243365002857	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
243365002858	catalytic triad [active]
243365002859	Autotransporter beta-domain; Region: Autotransporter; cl17461
243365002860	SAF-like; Region: SAF_2; pfam13144
243365002861	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
243365002862	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
243365002863	FlgN protein; Region: FlgN; pfam05130
243365002864	CobD/CbiB family protein; Provisional; Region: PRK07630
243365002865	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
243365002866	DEAD-like helicases superfamily; Region: DEXDc; smart00487
243365002867	ATP binding site [chemical binding]; other site
243365002868	Mg++ binding site [ion binding]; other site
243365002869	motif III; other site
243365002870	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243365002871	nucleotide binding region [chemical binding]; other site
243365002872	ATP-binding site [chemical binding]; other site
243365002873	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
243365002874	Cation efflux family; Region: Cation_efflux; pfam01545
243365002875	serine/threonine protein kinase; Provisional; Region: PRK11768
243365002876	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
243365002877	Response regulator receiver domain; Region: Response_reg; pfam00072
243365002878	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365002879	active site
243365002880	phosphorylation site [posttranslational modification]
243365002881	intermolecular recognition site; other site
243365002882	dimerization interface [polypeptide binding]; other site
243365002883	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243365002884	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
243365002885	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365002886	active site
243365002887	phosphorylation site [posttranslational modification]
243365002888	intermolecular recognition site; other site
243365002889	dimerization interface [polypeptide binding]; other site
243365002890	CheB methylesterase; Region: CheB_methylest; pfam01339
243365002891	CheD chemotactic sensory transduction; Region: CheD; cl00810
243365002892	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243365002893	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365002894	dimer interface [polypeptide binding]; other site
243365002895	putative CheW interface [polypeptide binding]; other site
243365002896	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
243365002897	putative CheA interaction surface; other site
243365002898	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243365002899	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365002900	dimer interface [polypeptide binding]; other site
243365002901	putative CheW interface [polypeptide binding]; other site
243365002902	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
243365002903	putative binding surface; other site
243365002904	active site
243365002905	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
243365002906	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
243365002907	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365002908	ATP binding site [chemical binding]; other site
243365002909	Mg2+ binding site [ion binding]; other site
243365002910	G-X-G motif; other site
243365002911	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
243365002912	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
243365002913	anti sigma factor interaction site; other site
243365002914	regulatory phosphorylation site [posttranslational modification]; other site
243365002915	Response regulator receiver domain; Region: Response_reg; pfam00072
243365002916	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365002917	active site
243365002918	phosphorylation site [posttranslational modification]
243365002919	intermolecular recognition site; other site
243365002920	dimerization interface [polypeptide binding]; other site
243365002921	aspartate kinase; Reviewed; Region: PRK06635
243365002922	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
243365002923	putative nucleotide binding site [chemical binding]; other site
243365002924	putative catalytic residues [active]
243365002925	putative Mg ion binding site [ion binding]; other site
243365002926	putative aspartate binding site [chemical binding]; other site
243365002927	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
243365002928	putative allosteric regulatory site; other site
243365002929	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
243365002930	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
243365002931	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
243365002932	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
243365002933	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
243365002934	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
243365002935	active site
243365002936	catalytic site [active]
243365002937	substrate binding site [chemical binding]; other site
243365002938	nucleotide excision repair endonuclease; Provisional; Region: PRK10545
243365002939	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
243365002940	GIY-YIG motif/motif A; other site
243365002941	active site
243365002942	catalytic site [active]
243365002943	putative DNA binding site [nucleotide binding]; other site
243365002944	metal binding site [ion binding]; metal-binding site
243365002945	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
243365002946	flagellar motor protein; Reviewed; Region: motC; PRK09109
243365002947	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
243365002948	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
243365002949	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
243365002950	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
243365002951	DNA binding residues [nucleotide binding]
243365002952	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
243365002953	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK06995
243365002954	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
243365002955	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
243365002956	FHIPEP family; Region: FHIPEP; pfam00771
243365002957	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
243365002958	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
243365002959	thymidylate synthase; Reviewed; Region: thyA; PRK01827
243365002960	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
243365002961	dimerization interface [polypeptide binding]; other site
243365002962	active site
243365002963	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
243365002964	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
243365002965	folate binding site [chemical binding]; other site
243365002966	NADP+ binding site [chemical binding]; other site
243365002967	Transcriptional regulators [Transcription]; Region: GntR; COG1802
243365002968	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
243365002969	DNA-binding site [nucleotide binding]; DNA binding site
243365002970	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
243365002971	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365002972	S-adenosylmethionine binding site [chemical binding]; other site
243365002973	N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045
243365002974	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
243365002975	active site
243365002976	putative substrate binding pocket [chemical binding]; other site
243365002977	PAS domain S-box; Region: sensory_box; TIGR00229
243365002978	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365002979	putative active site [active]
243365002980	heme pocket [chemical binding]; other site
243365002981	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365002982	PAS domain; Region: PAS_9; pfam13426
243365002983	putative active site [active]
243365002984	heme pocket [chemical binding]; other site
243365002985	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365002986	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365002987	metal binding site [ion binding]; metal-binding site
243365002988	active site
243365002989	I-site; other site
243365002990	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243365002991	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
243365002992	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365002993	putative active site [active]
243365002994	heme pocket [chemical binding]; other site
243365002995	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365002996	putative active site [active]
243365002997	heme pocket [chemical binding]; other site
243365002998	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
243365002999	GAF domain; Region: GAF; pfam01590
243365003000	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
243365003001	GAF domain; Region: GAF; pfam01590
243365003002	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365003003	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365003004	metal binding site [ion binding]; metal-binding site
243365003005	active site
243365003006	I-site; other site
243365003007	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243365003008	Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650
243365003009	Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956
243365003010	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243365003011	Walker A motif; other site
243365003012	ATP binding site [chemical binding]; other site
243365003013	Walker B motif; other site
243365003014	arginine finger; other site
243365003015	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
243365003016	hypothetical protein; Reviewed; Region: PRK09588
243365003017	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
243365003018	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
243365003019	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
243365003020	FAD binding domain; Region: FAD_binding_4; pfam01565
243365003021	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
243365003022	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
243365003023	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 3; Region: PLPDE_III_DSD_D-TA_like_3; cd06814
243365003024	dimer interface [polypeptide binding]; other site
243365003025	active site
243365003026	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
243365003027	substrate binding site [chemical binding]; other site
243365003028	catalytic residue [active]
243365003029	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
243365003030	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
243365003031	short chain dehydrogenase; Provisional; Region: PRK07478
243365003032	classical (c) SDRs; Region: SDR_c; cd05233
243365003033	NAD(P) binding site [chemical binding]; other site
243365003034	active site
243365003035	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365003036	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
243365003037	Coenzyme A binding pocket [chemical binding]; other site
243365003038	Uncharacterized conserved protein [Function unknown]; Region: COG3791
243365003039	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
243365003040	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
243365003041	non-specific DNA binding site [nucleotide binding]; other site
243365003042	salt bridge; other site
243365003043	sequence-specific DNA binding site [nucleotide binding]; other site
243365003044	Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406
243365003045	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
243365003046	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
243365003047	dimer interface [polypeptide binding]; other site
243365003048	putative anticodon binding site; other site
243365003049	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
243365003050	motif 1; other site
243365003051	active site
243365003052	motif 2; other site
243365003053	motif 3; other site
243365003054	peptide chain release factor 2; Provisional; Region: PRK08787
243365003055	This domain is found in peptide chain release factors; Region: PCRF; smart00937
243365003056	RF-1 domain; Region: RF-1; pfam00472
243365003057	malate dehydrogenase; Provisional; Region: PRK05442
243365003058	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
243365003059	NAD(P) binding site [chemical binding]; other site
243365003060	dimer interface [polypeptide binding]; other site
243365003061	malate binding site [chemical binding]; other site
243365003062	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
243365003063	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
243365003064	DNA-binding site [nucleotide binding]; DNA binding site
243365003065	UTRA domain; Region: UTRA; pfam07702
243365003066	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
243365003067	Iron-sulfur protein interface; other site
243365003068	proximal quinone binding site [chemical binding]; other site
243365003069	SdhD (CybS) interface [polypeptide binding]; other site
243365003070	proximal heme binding site [chemical binding]; other site
243365003071	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
243365003072	SdhC subunit interface [polypeptide binding]; other site
243365003073	proximal heme binding site [chemical binding]; other site
243365003074	cardiolipin binding site; other site
243365003075	Iron-sulfur protein interface; other site
243365003076	proximal quinone binding site [chemical binding]; other site
243365003077	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057
243365003078	L-aspartate oxidase; Provisional; Region: PRK06175
243365003079	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
243365003080	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
243365003081	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
243365003082	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
243365003083	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
243365003084	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
243365003085	dimer interface [polypeptide binding]; other site
243365003086	active site
243365003087	citrylCoA binding site [chemical binding]; other site
243365003088	NADH binding [chemical binding]; other site
243365003089	cationic pore residues; other site
243365003090	oxalacetate/citrate binding site [chemical binding]; other site
243365003091	coenzyme A binding site [chemical binding]; other site
243365003092	catalytic triad [active]
243365003093	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
243365003094	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
243365003095	TPP-binding site [chemical binding]; other site
243365003096	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
243365003097	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
243365003098	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
243365003099	E3 interaction surface; other site
243365003100	lipoyl attachment site [posttranslational modification]; other site
243365003101	e3 binding domain; Region: E3_binding; pfam02817
243365003102	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
243365003103	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
243365003104	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
243365003105	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
243365003106	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
243365003107	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
243365003108	CoA-ligase; Region: Ligase_CoA; pfam00549
243365003109	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
243365003110	CoA binding domain; Region: CoA_binding; smart00881
243365003111	CoA-ligase; Region: Ligase_CoA; pfam00549
243365003112	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243365003113	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
243365003114	Bacterial transcriptional repressor; Region: TetR; pfam13972
243365003115	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
243365003116	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365003117	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
243365003118	Cache domain; Region: Cache_1; pfam02743
243365003119	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243365003120	dimerization interface [polypeptide binding]; other site
243365003121	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243365003122	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365003123	dimer interface [polypeptide binding]; other site
243365003124	putative CheW interface [polypeptide binding]; other site
243365003125	Cache domain; Region: Cache_1; pfam02743
243365003126	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243365003127	dimerization interface [polypeptide binding]; other site
243365003128	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243365003129	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365003130	dimer interface [polypeptide binding]; other site
243365003131	putative CheW interface [polypeptide binding]; other site
243365003132	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
243365003133	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
243365003134	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
243365003135	ATP-binding site [chemical binding]; other site
243365003136	Sugar specificity; other site
243365003137	Pyrimidine base specificity; other site
243365003138	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
243365003139	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
243365003140	putative C-terminal domain interface [polypeptide binding]; other site
243365003141	putative GSH binding site (G-site) [chemical binding]; other site
243365003142	putative dimer interface [polypeptide binding]; other site
243365003143	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
243365003144	putative N-terminal domain interface [polypeptide binding]; other site
243365003145	putative dimer interface [polypeptide binding]; other site
243365003146	putative substrate binding pocket (H-site) [chemical binding]; other site
243365003147	FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412
243365003148	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
243365003149	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
243365003150	catalytic loop [active]
243365003151	iron binding site [ion binding]; other site
243365003152	chaperone protein HscA; Provisional; Region: hscA; PRK05183
243365003153	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
243365003154	nucleotide binding site [chemical binding]; other site
243365003155	putative NEF/HSP70 interaction site [polypeptide binding]; other site
243365003156	SBD interface [polypeptide binding]; other site
243365003157	co-chaperone HscB; Provisional; Region: hscB; PRK03578
243365003158	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
243365003159	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
243365003160	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
243365003161	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
243365003162	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
243365003163	trimerization site [polypeptide binding]; other site
243365003164	active site
243365003165	cysteine desulfurase; Provisional; Region: PRK14012
243365003166	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
243365003167	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
243365003168	catalytic residue [active]
243365003169	iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010
243365003170	Rrf2 family protein; Region: rrf2_super; TIGR00738
243365003171	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515
243365003172	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
243365003173	dimer interface [polypeptide binding]; other site
243365003174	active site
243365003175	CoA binding pocket [chemical binding]; other site
243365003176	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
243365003177	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
243365003178	peptide binding site [polypeptide binding]; other site
243365003179	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
243365003180	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365003181	dimer interface [polypeptide binding]; other site
243365003182	conserved gate region; other site
243365003183	putative PBP binding loops; other site
243365003184	ABC-ATPase subunit interface; other site
243365003185	dipeptide transporter; Provisional; Region: PRK10913
243365003186	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
243365003187	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365003188	dimer interface [polypeptide binding]; other site
243365003189	conserved gate region; other site
243365003190	putative PBP binding loops; other site
243365003191	ABC-ATPase subunit interface; other site
243365003192	dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022
243365003193	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
243365003194	Walker A/P-loop; other site
243365003195	ATP binding site [chemical binding]; other site
243365003196	Q-loop/lid; other site
243365003197	ABC transporter signature motif; other site
243365003198	Walker B; other site
243365003199	D-loop; other site
243365003200	H-loop/switch region; other site
243365003201	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
243365003202	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
243365003203	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
243365003204	Walker A/P-loop; other site
243365003205	ATP binding site [chemical binding]; other site
243365003206	Q-loop/lid; other site
243365003207	ABC transporter signature motif; other site
243365003208	Walker B; other site
243365003209	D-loop; other site
243365003210	H-loop/switch region; other site
243365003211	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
243365003212	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
243365003213	dimer interface [polypeptide binding]; other site
243365003214	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
243365003215	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
243365003216	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
243365003217	active site
243365003218	(T/H)XGH motif; other site
243365003219	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365003220	S-adenosylmethionine binding site [chemical binding]; other site
243365003221	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
243365003222	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
243365003223	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
243365003224	catalytic residues [active]
243365003225	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
243365003226	catalytic residues [active]
243365003227	dimer interface [polypeptide binding]; other site
243365003228	Inward rectifier potassium channel; Region: IRK; pfam01007
243365003229	GAF domain; Region: GAF; cl17456
243365003230	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365003231	PAS fold; Region: PAS_3; pfam08447
243365003232	putative active site [active]
243365003233	heme pocket [chemical binding]; other site
243365003234	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243365003235	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
243365003236	dimer interface [polypeptide binding]; other site
243365003237	phosphorylation site [posttranslational modification]
243365003238	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365003239	ATP binding site [chemical binding]; other site
243365003240	Mg2+ binding site [ion binding]; other site
243365003241	G-X-G motif; other site
243365003242	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
243365003243	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
243365003244	domain interface [polypeptide binding]; other site
243365003245	putative active site [active]
243365003246	catalytic site [active]
243365003247	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
243365003248	domain interface [polypeptide binding]; other site
243365003249	putative active site [active]
243365003250	catalytic site [active]
243365003251	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
243365003252	putative active site [active]
243365003253	Ap4A binding site [chemical binding]; other site
243365003254	nudix motif; other site
243365003255	putative metal binding site [ion binding]; other site
243365003256	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
243365003257	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365003258	ATP binding site [chemical binding]; other site
243365003259	Mg2+ binding site [ion binding]; other site
243365003260	G-X-G motif; other site
243365003261	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
243365003262	anchoring element; other site
243365003263	dimer interface [polypeptide binding]; other site
243365003264	ATP binding site [chemical binding]; other site
243365003265	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
243365003266	active site
243365003267	metal binding site [ion binding]; metal-binding site
243365003268	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
243365003269	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243365003270	substrate binding pocket [chemical binding]; other site
243365003271	membrane-bound complex binding site; other site
243365003272	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
243365003273	putative NAD(P) binding site [chemical binding]; other site
243365003274	homodimer interface [polypeptide binding]; other site
243365003275	transcriptional regulator; Provisional; Region: PRK10632
243365003276	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365003277	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477
243365003278	putative effector binding pocket; other site
243365003279	putative dimerization interface [polypeptide binding]; other site
243365003280	Chromate transporter; Region: Chromate_transp; pfam02417
243365003281	Chromate transporter; Region: Chromate_transp; pfam02417
243365003282	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
243365003283	membrane-bound complex binding site; other site
243365003284	hinge residues; other site
243365003285	fumarate hydratase; Reviewed; Region: fumC; PRK00485
243365003286	Class II fumarases; Region: Fumarase_classII; cd01362
243365003287	active site
243365003288	tetramer interface [polypeptide binding]; other site
243365003289	aconitate hydratase; Validated; Region: PRK09277
243365003290	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
243365003291	substrate binding site [chemical binding]; other site
243365003292	ligand binding site [chemical binding]; other site
243365003293	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
243365003294	substrate binding site [chemical binding]; other site
243365003295	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
243365003296	substrate binding site [chemical binding]; other site
243365003297	active site
243365003298	primosome assembly protein PriA; Validated; Region: PRK05580
243365003299	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
243365003300	ATP binding site [chemical binding]; other site
243365003301	putative Mg++ binding site [ion binding]; other site
243365003302	helicase superfamily c-terminal domain; Region: HELICc; smart00490
243365003303	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
243365003304	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
243365003305	GSH binding site [chemical binding]; other site
243365003306	catalytic residues [active]
243365003307	preprotein translocase subunit SecB; Validated; Region: PRK05751
243365003308	SecA binding site; other site
243365003309	Preprotein binding site; other site
243365003310	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807
243365003311	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
243365003312	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
243365003313	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
243365003314	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
243365003315	GTP cyclohydrolase I; Provisional; Region: PLN03044
243365003316	active site
243365003317	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
243365003318	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
243365003319	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365003320	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365003321	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
243365003322	putative effector binding pocket; other site
243365003323	dimerization interface [polypeptide binding]; other site
243365003324	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
243365003325	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
243365003326	EamA-like transporter family; Region: EamA; pfam00892
243365003327	EamA-like transporter family; Region: EamA; pfam00892
243365003328	active site clefts [active]
243365003329	Carbonic anhydrase; Region: Pro_CA; pfam00484
243365003330	zinc binding site [ion binding]; other site
243365003331	dimer interface [polypeptide binding]; other site
243365003332	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
243365003333	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
243365003334	putative catalytic cysteine [active]
243365003335	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
243365003336	putative active site [active]
243365003337	metal binding site [ion binding]; metal-binding site
243365003338	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
243365003339	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365003340	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365003341	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
243365003342	putative effector binding pocket; other site
243365003343	putative dimerization interface [polypeptide binding]; other site
243365003344	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
243365003345	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
243365003346	active site
243365003347	catalytic tetrad [active]
243365003348	Cation efflux family; Region: Cation_efflux; cl00316
243365003349	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365003350	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365003351	metal binding site [ion binding]; metal-binding site
243365003352	active site
243365003353	I-site; other site
243365003354	DinB family; Region: DinB; cl17821
243365003355	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
243365003356	oligomer interface [polypeptide binding]; other site
243365003357	active site residues [active]
243365003358	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
243365003359	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
243365003360	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
243365003361	ATP binding site [chemical binding]; other site
243365003362	putative Mg++ binding site [ion binding]; other site
243365003363	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243365003364	nucleotide binding region [chemical binding]; other site
243365003365	ATP-binding site [chemical binding]; other site
243365003366	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
243365003367	PAS fold; Region: PAS_4; pfam08448
243365003368	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365003369	putative active site [active]
243365003370	heme pocket [chemical binding]; other site
243365003371	PAS domain S-box; Region: sensory_box; TIGR00229
243365003372	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365003373	putative active site [active]
243365003374	heme pocket [chemical binding]; other site
243365003375	PAS domain S-box; Region: sensory_box; TIGR00229
243365003376	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365003377	putative active site [active]
243365003378	heme pocket [chemical binding]; other site
243365003379	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365003380	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365003381	metal binding site [ion binding]; metal-binding site
243365003382	active site
243365003383	I-site; other site
243365003384	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243365003385	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
243365003386	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
243365003387	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
243365003388	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365003389	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365003390	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
243365003391	putative dimerization interface [polypeptide binding]; other site
243365003392	LrgA family; Region: LrgA; pfam03788
243365003393	LrgB-like family; Region: LrgB; pfam04172
243365003394	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
243365003395	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
243365003396	DNA binding residues [nucleotide binding]
243365003397	dimer interface [polypeptide binding]; other site
243365003398	putative metal binding site [ion binding]; other site
243365003399	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
243365003400	Heavy-metal-associated domain; Region: HMA; pfam00403
243365003401	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
243365003402	Soluble P-type ATPase [General function prediction only]; Region: COG4087
243365003403	SprA-related family; Region: SprA-related; pfam12118
243365003404	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
243365003405	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
243365003406	active site
243365003407	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807
243365003408	putative active site [active]
243365003409	YdjC motif; other site
243365003410	Mg binding site [ion binding]; other site
243365003411	putative homodimer interface [polypeptide binding]; other site
243365003412	GtrA-like protein; Region: GtrA; pfam04138
243365003413	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
243365003414	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
243365003415	Ligand binding site; other site
243365003416	Putative Catalytic site; other site
243365003417	DXD motif; other site
243365003418	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
243365003419	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
243365003420	Major Facilitator Superfamily; Region: MFS_1; pfam07690
243365003421	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365003422	putative substrate translocation pore; other site
243365003423	tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238
243365003424	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
243365003425	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
243365003426	catalytic residue [active]
243365003427	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
243365003428	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
243365003429	putative C-terminal domain interface [polypeptide binding]; other site
243365003430	putative GSH binding site (G-site) [chemical binding]; other site
243365003431	putative dimer interface [polypeptide binding]; other site
243365003432	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
243365003433	dimer interface [polypeptide binding]; other site
243365003434	N-terminal domain interface [polypeptide binding]; other site
243365003435	putative substrate binding pocket (H-site) [chemical binding]; other site
243365003436	YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function.  The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336
243365003437	putative deacylase active site [active]
243365003438	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
243365003439	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
243365003440	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
243365003441	H+ Antiporter protein; Region: 2A0121; TIGR00900
243365003442	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198
243365003443	FixH; Region: FixH; pfam05751
243365003444	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
243365003445	4Fe-4S binding domain; Region: Fer4_5; pfam12801
243365003446	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
243365003447	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
243365003448	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
243365003449	Cytochrome c; Region: Cytochrom_C; pfam00034
243365003450	Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545
243365003451	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
243365003452	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
243365003453	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
243365003454	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
243365003455	Low-spin heme binding site [chemical binding]; other site
243365003456	Putative water exit pathway; other site
243365003457	Binuclear center (active site) [active]
243365003458	Putative proton exit pathway; other site
243365003459	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
243365003460	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
243365003461	aminopeptidase N; Provisional; Region: pepN; PRK14015
243365003462	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
243365003463	active site
243365003464	Zn binding site [ion binding]; other site
243365003465	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
243365003466	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
243365003467	putative dimer interface [polypeptide binding]; other site
243365003468	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
243365003469	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
243365003470	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
243365003471	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365003472	putative substrate translocation pore; other site
243365003473	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
243365003474	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
243365003475	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
243365003476	homotrimer interaction site [polypeptide binding]; other site
243365003477	putative active site [active]
243365003478	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
243365003479	homotrimer interaction site [polypeptide binding]; other site
243365003480	putative active site [active]
243365003481	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
243365003482	homotrimer interaction site [polypeptide binding]; other site
243365003483	putative active site [active]
243365003484	Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751
243365003485	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
243365003486	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
243365003487	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
243365003488	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
243365003489	ethanolamine permease; Region: 2A0305; TIGR00908
243365003490	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
243365003491	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
243365003492	Tetramer interface [polypeptide binding]; other site
243365003493	active site
243365003494	FMN-binding site [chemical binding]; other site
243365003495	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
243365003496	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
243365003497	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365003498	active site
243365003499	phosphorylation site [posttranslational modification]
243365003500	intermolecular recognition site; other site
243365003501	dimerization interface [polypeptide binding]; other site
243365003502	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243365003503	Zn2+ binding site [ion binding]; other site
243365003504	Mg2+ binding site [ion binding]; other site
243365003505	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365003506	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
243365003507	putative active site [active]
243365003508	heme pocket [chemical binding]; other site
243365003509	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365003510	putative active site [active]
243365003511	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243365003512	heme pocket [chemical binding]; other site
243365003513	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243365003514	dimer interface [polypeptide binding]; other site
243365003515	phosphorylation site [posttranslational modification]
243365003516	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365003517	ATP binding site [chemical binding]; other site
243365003518	Mg2+ binding site [ion binding]; other site
243365003519	G-X-G motif; other site
243365003520	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
243365003521	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365003522	active site
243365003523	phosphorylation site [posttranslational modification]
243365003524	intermolecular recognition site; other site
243365003525	dimerization interface [polypeptide binding]; other site
243365003526	Response regulator receiver domain; Region: Response_reg; pfam00072
243365003527	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365003528	active site
243365003529	phosphorylation site [posttranslational modification]
243365003530	intermolecular recognition site; other site
243365003531	dimerization interface [polypeptide binding]; other site
243365003532	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
243365003533	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365003534	dimer interface [polypeptide binding]; other site
243365003535	conserved gate region; other site
243365003536	putative PBP binding loops; other site
243365003537	ABC-ATPase subunit interface; other site
243365003538	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
243365003539	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365003540	dimer interface [polypeptide binding]; other site
243365003541	conserved gate region; other site
243365003542	ABC-ATPase subunit interface; other site
243365003543	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
243365003544	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
243365003545	Walker A/P-loop; other site
243365003546	ATP binding site [chemical binding]; other site
243365003547	Q-loop/lid; other site
243365003548	ABC transporter signature motif; other site
243365003549	Walker B; other site
243365003550	D-loop; other site
243365003551	H-loop/switch region; other site
243365003552	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc; cd04582
243365003553	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
243365003554	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
243365003555	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048
243365003556	RNAase interaction site [polypeptide binding]; other site
243365003557	microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th,  Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212
243365003558	active site
243365003559	glutamate racemase; Provisional; Region: PRK00865
243365003560	antiporter inner membrane protein; Provisional; Region: PRK11670
243365003561	Domain of unknown function DUF59; Region: DUF59; pfam01883
243365003562	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
243365003563	Walker A motif; other site
243365003564	multidrug efflux system translocase MdfA; Provisional; Region: PRK15402
243365003565	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365003566	putative substrate translocation pore; other site
243365003567	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
243365003568	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
243365003569	active site
243365003570	HIGH motif; other site
243365003571	KMSKS motif; other site
243365003572	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
243365003573	tRNA binding surface [nucleotide binding]; other site
243365003574	anticodon binding site; other site
243365003575	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
243365003576	dimer interface [polypeptide binding]; other site
243365003577	putative tRNA-binding site [nucleotide binding]; other site
243365003578	Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009
243365003579	YfjP GTPase; Region: YfjP; cd11383
243365003580	G1 box; other site
243365003581	GTP/Mg2+ binding site [chemical binding]; other site
243365003582	Switch I region; other site
243365003583	G2 box; other site
243365003584	Switch II region; other site
243365003585	G3 box; other site
243365003586	G4 box; other site
243365003587	G5 box; other site
243365003588	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
243365003589	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
243365003590	non-specific DNA binding site [nucleotide binding]; other site
243365003591	salt bridge; other site
243365003592	sequence-specific DNA binding site [nucleotide binding]; other site
243365003593	Protein of unknown function (DUF3768); Region: DUF3768; pfam12599
243365003594	phage/plasmid-like protein TIGR03299; Region: LGT_TIGR03299
243365003595	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
243365003596	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365003597	putative substrate translocation pore; other site
243365003598	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
243365003599	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
243365003600	DNA binding residues [nucleotide binding]
243365003601	dimerization interface [polypeptide binding]; other site
243365003602	Methyltransferase domain; Region: Methyltransf_23; pfam13489
243365003603	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365003604	S-adenosylmethionine binding site [chemical binding]; other site
243365003605	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
243365003606	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
243365003607	NAD(P) binding site [chemical binding]; other site
243365003608	catalytic residues [active]
243365003609	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
243365003610	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
243365003611	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
243365003612	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
243365003613	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752
243365003614	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757
243365003615	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689
243365003616	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637
243365003617	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721
243365003618	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
243365003619	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
243365003620	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
243365003621	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
243365003622	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
243365003623	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
243365003624	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
243365003625	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
243365003626	putative active site [active]
243365003627	putative active site [active]
243365003628	catalytic site [active]
243365003629	catalytic site [active]
243365003630	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
243365003631	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
243365003632	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
243365003633	putative active site [active]
243365003634	catalytic site [active]
243365003635	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
243365003636	Sel1-like repeats; Region: SEL1; smart00671
243365003637	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
243365003638	RHS Repeat; Region: RHS_repeat; pfam05593
243365003639	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
243365003640	RHS Repeat; Region: RHS_repeat; pfam05593
243365003641	RHS Repeat; Region: RHS_repeat; pfam05593
243365003642	RHS Repeat; Region: RHS_repeat; pfam05593
243365003643	RHS Repeat; Region: RHS_repeat; pfam05593
243365003644	RHS Repeat; Region: RHS_repeat; pfam05593
243365003645	RHS Repeat; Region: RHS_repeat; cl11982
243365003646	RHS Repeat; Region: RHS_repeat; pfam05593
243365003647	RHS protein; Region: RHS; pfam03527
243365003648	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
243365003649	H-NS histone family; Region: Histone_HNS; pfam00816
243365003650	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
243365003651	Protein of unknown function (DUF3296); Region: DUF3296; pfam11726
243365003652	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
243365003653	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
243365003654	HTH-like domain; Region: HTH_21; pfam13276
243365003655	Integrase core domain; Region: rve; pfam00665
243365003656	Integrase core domain; Region: rve_3; pfam13683
243365003657	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
243365003658	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365003659	Coenzyme A binding pocket [chemical binding]; other site
243365003660	hypothetical protein; Validated; Region: PRK02101
243365003661	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
243365003662	putative active site [active]
243365003663	dimerization interface [polypeptide binding]; other site
243365003664	putative tRNAtyr binding site [nucleotide binding]; other site
243365003665	Predicted membrane protein [Function unknown]; Region: COG1289
243365003666	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
243365003667	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
243365003668	N-acetyl-D-glucosamine binding site [chemical binding]; other site
243365003669	catalytic residue [active]
243365003670	LysM domain; Region: LysM; pfam01476
243365003671	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
243365003672	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
243365003673	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
243365003674	Methyltransferase domain; Region: Methyltransf_11; pfam08241
243365003675	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
243365003676	RNA/DNA hybrid binding site [nucleotide binding]; other site
243365003677	active site
243365003678	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
243365003679	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
243365003680	active site
243365003681	catalytic site [active]
243365003682	substrate binding site [chemical binding]; other site
243365003683	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
243365003684	substrate binding site; other site
243365003685	dimer interface; other site
243365003686	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
243365003687	homotrimer interaction site [polypeptide binding]; other site
243365003688	zinc binding site [ion binding]; other site
243365003689	CDP-binding sites; other site
243365003690	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
243365003691	tetramer (dimer of dimers) interface [polypeptide binding]; other site
243365003692	active site
243365003693	dimer interface [polypeptide binding]; other site
243365003694	transcriptional regulator PhoU; Provisional; Region: PRK11115
243365003695	PhoU domain; Region: PhoU; pfam01895
243365003696	PhoU domain; Region: PhoU; pfam01895
243365003697	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
243365003698	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
243365003699	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
243365003700	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
243365003701	oligomer interface [polypeptide binding]; other site
243365003702	metal binding site [ion binding]; metal-binding site
243365003703	metal binding site [ion binding]; metal-binding site
243365003704	Cl binding site [ion binding]; other site
243365003705	aspartate ring; other site
243365003706	basic sphincter; other site
243365003707	putative hydrophobic gate; other site
243365003708	periplasmic entrance; other site
243365003709	Isochorismatase family; Region: Isochorismatase; pfam00857
243365003710	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
243365003711	catalytic triad [active]
243365003712	metal binding site [ion binding]; metal-binding site
243365003713	conserved cis-peptide bond; other site
243365003714	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
243365003715	metal-binding site [ion binding]
243365003716	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
243365003717	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
243365003718	metal-binding site [ion binding]
243365003719	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
243365003720	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
243365003721	metal-binding site [ion binding]
243365003722	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
243365003723	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241
243365003724	putative active site [active]
243365003725	Zn binding site [ion binding]; other site
243365003726	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
243365003727	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
243365003728	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
243365003729	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
243365003730	Chromate transporter; Region: Chromate_transp; pfam02417
243365003731	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
243365003732	beta-galactosidase; Region: BGL; TIGR03356
243365003733	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365003734	dimer interface [polypeptide binding]; other site
243365003735	conserved gate region; other site
243365003736	putative PBP binding loops; other site
243365003737	ABC-ATPase subunit interface; other site
243365003738	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365003739	dimer interface [polypeptide binding]; other site
243365003740	conserved gate region; other site
243365003741	putative PBP binding loops; other site
243365003742	ABC-ATPase subunit interface; other site
243365003743	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243365003744	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243365003745	substrate binding pocket [chemical binding]; other site
243365003746	membrane-bound complex binding site; other site
243365003747	hinge residues; other site
243365003748	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
243365003749	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
243365003750	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
243365003751	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
243365003752	Predicted ATPase [General function prediction only]; Region: COG4637
243365003753	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243365003754	Walker A/P-loop; other site
243365003755	ATP binding site [chemical binding]; other site
243365003756	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243365003757	ABC transporter signature motif; other site
243365003758	Walker B; other site
243365003759	D-loop; other site
243365003760	H-loop/switch region; other site
243365003761	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365003762	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365003763	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
243365003764	putative effector binding pocket; other site
243365003765	dimerization interface [polypeptide binding]; other site
243365003766	Pirin-related protein [General function prediction only]; Region: COG1741
243365003767	Pirin; Region: Pirin; pfam02678
243365003768	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
243365003769	catalytic triad [active]
243365003770	dimer interface [polypeptide binding]; other site
243365003771	Isochorismatase family; Region: Isochorismatase; pfam00857
243365003772	conserved cis-peptide bond; other site
243365003773	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
243365003774	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
243365003775	active site
243365003776	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
243365003777	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
243365003778	dimer interface [polypeptide binding]; other site
243365003779	active site
243365003780	glycine-pyridoxal phosphate binding site [chemical binding]; other site
243365003781	folate binding site [chemical binding]; other site
243365003782	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
243365003783	ATP cone domain; Region: ATP-cone; pfam03477
243365003784	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
243365003785	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
243365003786	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
243365003787	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
243365003788	Coenzyme A binding pocket [chemical binding]; other site
243365003789	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
243365003790	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
243365003791	catalytic motif [active]
243365003792	Zn binding site [ion binding]; other site
243365003793	RibD C-terminal domain; Region: RibD_C; cl17279
243365003794	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
243365003795	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
243365003796	active site
243365003797	Zn binding site [ion binding]; other site
243365003798	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
243365003799	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
243365003800	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
243365003801	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
243365003802	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
243365003803	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
243365003804	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
243365003805	PapC N-terminal domain; Region: PapC_N; pfam13954
243365003806	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
243365003807	PapC C-terminal domain; Region: PapC_C; pfam13953
243365003808	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
243365003809	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365003810	putative substrate translocation pore; other site
243365003811	choline dehydrogenase; Validated; Region: PRK02106
243365003812	lycopene cyclase; Region: lycopene_cycl; TIGR01789
243365003813	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
243365003814	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365003815	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365003816	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
243365003817	dimerization interface [polypeptide binding]; other site
243365003818	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
243365003819	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
243365003820	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
243365003821	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
243365003822	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
243365003823	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
243365003824	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
243365003825	active site
243365003826	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
243365003827	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
243365003828	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
243365003829	GIY-YIG motif/motif A; other site
243365003830	active site
243365003831	catalytic site [active]
243365003832	putative DNA binding site [nucleotide binding]; other site
243365003833	metal binding site [ion binding]; metal-binding site
243365003834	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
243365003835	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
243365003836	Salmonella virulence-associated 28kDa protein; Region: VRP3; pfam03536
243365003837	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
243365003838	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
243365003839	amidase catalytic site [active]
243365003840	Zn binding residues [ion binding]; other site
243365003841	substrate binding site [chemical binding]; other site
243365003842	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
243365003843	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
243365003844	beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289
243365003845	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
243365003846	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
243365003847	conserved cys residue [active]
243365003848	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
243365003849	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
243365003850	conserved cys residue [active]
243365003851	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
243365003852	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
243365003853	Protein of unknown function (DUF3380); Region: DUF3380; pfam11860
243365003854	FinO bacterial conjugation repressor domain;  the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270
243365003855	heat shock protein 90; Provisional; Region: PRK05218
243365003856	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365003857	ATP binding site [chemical binding]; other site
243365003858	Mg2+ binding site [ion binding]; other site
243365003859	G-X-G motif; other site
243365003860	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355
243365003861	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
243365003862	Isochorismatase family; Region: Isochorismatase; pfam00857
243365003863	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
243365003864	catalytic triad [active]
243365003865	conserved cis-peptide bond; other site
243365003866	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
243365003867	Predicted amidohydrolase [General function prediction only]; Region: COG0388
243365003868	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
243365003869	active site
243365003870	catalytic triad [active]
243365003871	dimer interface [polypeptide binding]; other site
243365003872	OsmC-like protein; Region: OsmC; cl00767
243365003873	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
243365003874	catalytic residues [active]
243365003875	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Sulfolobus solfataricus (Ss) and its homologs from archaea and bacteria; Region: NTP-PPase_SsMazG; cd11535
243365003876	metal binding site [ion binding]; metal-binding site
243365003877	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
243365003878	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
243365003879	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243365003880	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365003881	dimer interface [polypeptide binding]; other site
243365003882	putative CheW interface [polypeptide binding]; other site
243365003883	exonuclease I; Provisional; Region: sbcB; PRK11779
243365003884	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
243365003885	active site
243365003886	catalytic site [active]
243365003887	substrate binding site [chemical binding]; other site
243365003888	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
243365003889	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
243365003890	enoyl-CoA hydratase; Provisional; Region: PRK05995
243365003891	substrate binding site [chemical binding]; other site
243365003892	oxyanion hole (OAH) forming residues; other site
243365003893	trimer interface [polypeptide binding]; other site
243365003894	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
243365003895	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243365003896	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598
243365003897	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365003898	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365003899	metal binding site [ion binding]; metal-binding site
243365003900	active site
243365003901	I-site; other site
243365003902	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
243365003903	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243365003904	Walker A/P-loop; other site
243365003905	ATP binding site [chemical binding]; other site
243365003906	Q-loop/lid; other site
243365003907	ABC transporter signature motif; other site
243365003908	Walker B; other site
243365003909	D-loop; other site
243365003910	H-loop/switch region; other site
243365003911	TOBE domain; Region: TOBE_2; pfam08402
243365003912	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
243365003913	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
243365003914	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
243365003915	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243365003916	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
243365003917	active site
243365003918	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
243365003919	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
243365003920	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365003921	ATP binding site [chemical binding]; other site
243365003922	Mg2+ binding site [ion binding]; other site
243365003923	G-X-G motif; other site
243365003924	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
243365003925	ATP binding site [chemical binding]; other site
243365003926	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
243365003927	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
243365003928	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
243365003929	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
243365003930	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
243365003931	Protein export membrane protein; Region: SecD_SecF; pfam02355
243365003932	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
243365003933	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
243365003934	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
243365003935	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
243365003936	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
243365003937	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
243365003938	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
243365003939	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
243365003940	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
243365003941	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
243365003942	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
243365003943	active site
243365003944	dimer interface [polypeptide binding]; other site
243365003945	motif 1; other site
243365003946	motif 2; other site
243365003947	motif 3; other site
243365003948	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
243365003949	anticodon binding site; other site
243365003950	translation initiation factor IF-3; Region: infC; TIGR00168
243365003951	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
243365003952	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
243365003953	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
243365003954	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
243365003955	23S rRNA binding site [nucleotide binding]; other site
243365003956	L21 binding site [polypeptide binding]; other site
243365003957	L13 binding site [polypeptide binding]; other site
243365003958	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
243365003959	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
243365003960	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
243365003961	dimer interface [polypeptide binding]; other site
243365003962	motif 1; other site
243365003963	active site
243365003964	motif 2; other site
243365003965	motif 3; other site
243365003966	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
243365003967	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
243365003968	putative tRNA-binding site [nucleotide binding]; other site
243365003969	B3/4 domain; Region: B3_4; pfam03483
243365003970	tRNA synthetase B5 domain; Region: B5; smart00874
243365003971	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
243365003972	dimer interface [polypeptide binding]; other site
243365003973	motif 1; other site
243365003974	motif 3; other site
243365003975	motif 2; other site
243365003976	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
243365003977	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
243365003978	IHF - DNA interface [nucleotide binding]; other site
243365003979	IHF dimer interface [polypeptide binding]; other site
243365003980	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
243365003981	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
243365003982	DNA binding residues [nucleotide binding]
243365003983	S-adenosylmethionine binding site [chemical binding]; other site
243365003984	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
243365003985	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
243365003986	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243365003987	dimerization interface [polypeptide binding]; other site
243365003988	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365003989	dimer interface [polypeptide binding]; other site
243365003990	putative CheW interface [polypeptide binding]; other site
243365003991	Predicted membrane protein [Function unknown]; Region: COG2119
243365003992	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
243365003993	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
243365003994	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
243365003995	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
243365003996	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
243365003997	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
243365003998	H-NS histone family; Region: Histone_HNS; pfam00816
243365003999	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
243365004000	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
243365004001	Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234
243365004002	putative active site [active]
243365004003	Zn binding site [ion binding]; other site
243365004004	Phasin protein; Region: Phasin_2; pfam09361
243365004005	polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848
243365004006	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
243365004007	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
243365004008	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
243365004009	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243365004010	TPR motif; other site
243365004011	binding surface
243365004012	TPR repeat; Region: TPR_11; pfam13414
243365004013	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243365004014	binding surface
243365004015	TPR motif; other site
243365004016	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365004017	S-adenosylmethionine binding site [chemical binding]; other site
243365004018	Domain of unknown function (DUF3472); Region: DUF3472; pfam11958
243365004019	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
243365004020	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
243365004021	putative sugar binding sites [chemical binding]; other site
243365004022	Q-X-W motif; other site
243365004023	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
243365004024	Domain of unknown function (DUF3472); Region: DUF3472; pfam11958
243365004025	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
243365004026	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
243365004027	Q-X-W motif; other site
243365004028	putative sugar binding sites [chemical binding]; other site
243365004029	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
243365004030	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
243365004031	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243365004032	FeS/SAM binding site; other site
243365004033	TRAM domain; Region: TRAM; cl01282
243365004034	FOG: CBS domain [General function prediction only]; Region: COG0517
243365004035	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
243365004036	FOG: CBS domain [General function prediction only]; Region: COG0517
243365004037	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
243365004038	FOG: CBS domain [General function prediction only]; Region: COG0517
243365004039	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365004040	PAS domain; Region: PAS_9; pfam13426
243365004041	putative active site [active]
243365004042	heme pocket [chemical binding]; other site
243365004043	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365004044	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365004045	metal binding site [ion binding]; metal-binding site
243365004046	active site
243365004047	I-site; other site
243365004048	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243365004049	seryl-tRNA synthetase; Provisional; Region: PRK05431
243365004050	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
243365004051	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
243365004052	dimer interface [polypeptide binding]; other site
243365004053	active site
243365004054	motif 1; other site
243365004055	motif 2; other site
243365004056	motif 3; other site
243365004057	recombination factor protein RarA; Reviewed; Region: PRK13342
243365004058	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243365004059	Walker A motif; other site
243365004060	ATP binding site [chemical binding]; other site
243365004061	Walker B motif; other site
243365004062	arginine finger; other site
243365004063	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
243365004064	elongation factor P; Validated; Region: PRK00529
243365004065	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
243365004066	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
243365004067	RNA binding site [nucleotide binding]; other site
243365004068	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
243365004069	RNA binding site [nucleotide binding]; other site
243365004070	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394
243365004071	Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093
243365004072	Domain of unknown function (DUF3404); Region: DUF3404; pfam11884
243365004073	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243365004074	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365004075	ATP binding site [chemical binding]; other site
243365004076	Mg2+ binding site [ion binding]; other site
243365004077	G-X-G motif; other site
243365004078	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
243365004079	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365004080	active site
243365004081	phosphorylation site [posttranslational modification]
243365004082	intermolecular recognition site; other site
243365004083	dimerization interface [polypeptide binding]; other site
243365004084	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
243365004085	DNA binding site [nucleotide binding]
243365004086	Protein of unknown function (DUF2861); Region: DUF2861; pfam11060
243365004087	Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308
243365004088	MASE1; Region: MASE1; pfam05231
243365004089	Esterase/lipase [General function prediction only]; Region: COG1647
243365004090	Acyl CoA binding protein; Region: ACBP; pfam00887
243365004091	acyl-CoA binding pocket [chemical binding]; other site
243365004092	CoA binding site [chemical binding]; other site
243365004093	Killing trait; Region: RebB; pfam11747
243365004094	Domain of unknown function (DUF1992); Region: DUF1992; pfam09350
243365004095	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365004096	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365004097	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
243365004098	putative effector binding pocket; other site
243365004099	dimerization interface [polypeptide binding]; other site
243365004100	Protein of unknown function (DUF2000); Region: DUF2000; pfam09391
243365004101	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
243365004102	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
243365004103	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243365004104	motif II; other site
243365004105	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
243365004106	active site
243365004107	catalytic residues [active]
243365004108	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
243365004109	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
243365004110	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
243365004111	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243365004112	motif II; other site
243365004113	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365004114	Major Facilitator Superfamily; Region: MFS_1; pfam07690
243365004115	putative substrate translocation pore; other site
243365004116	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
243365004117	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
243365004118	dimer interface [polypeptide binding]; other site
243365004119	ADP-ribose binding site [chemical binding]; other site
243365004120	active site
243365004121	nudix motif; other site
243365004122	metal binding site [ion binding]; metal-binding site
243365004123	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
243365004124	Fatty acid desaturase; Region: FA_desaturase; pfam00487
243365004125	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cd01060
243365004126	putative di-iron ligands [ion binding]; other site
243365004127	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
243365004128	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
243365004129	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243365004130	motif II; other site
243365004131	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
243365004132	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
243365004133	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
243365004134	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
243365004135	catalytic residue [active]
243365004136	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
243365004137	nudix motif; other site
243365004138	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
243365004139	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
243365004140	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
243365004141	catalytic residue [active]
243365004142	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
243365004143	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
243365004144	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
243365004145	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
243365004146	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
243365004147	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
243365004148	serine transporter; Region: stp; TIGR00814
243365004149	formate transporter FocA; Region: formate_focA; TIGR04060
243365004150	Pyruvate formate lyase 1; Region: PFL1; cd01678
243365004151	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
243365004152	coenzyme A binding site [chemical binding]; other site
243365004153	active site
243365004154	catalytic residues [active]
243365004155	glycine loop; other site
243365004156	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
243365004157	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243365004158	FeS/SAM binding site; other site
243365004159	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
243365004160	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
243365004161	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
243365004162	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
243365004163	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
243365004164	dimerization interface [polypeptide binding]; other site
243365004165	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365004166	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243365004167	dimer interface [polypeptide binding]; other site
243365004168	putative CheW interface [polypeptide binding]; other site
243365004169	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
243365004170	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365004171	active site
243365004172	phosphorylation site [posttranslational modification]
243365004173	intermolecular recognition site; other site
243365004174	dimerization interface [polypeptide binding]; other site
243365004175	LytTr DNA-binding domain; Region: LytTR; pfam04397
243365004176	Histidine kinase; Region: His_kinase; pfam06580
243365004177	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365004178	ATP binding site [chemical binding]; other site
243365004179	Mg2+ binding site [ion binding]; other site
243365004180	G-X-G motif; other site
243365004181	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
243365004182	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
243365004183	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
243365004184	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
243365004185	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
243365004186	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
243365004187	DNA binding site [nucleotide binding]
243365004188	active site
243365004189	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
243365004190	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
243365004191	putative substrate binding site [chemical binding]; other site
243365004192	putative ATP binding site [chemical binding]; other site
243365004193	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
243365004194	hypothetical protein; Reviewed; Region: PRK09588
243365004195	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
243365004196	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
243365004197	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
243365004198	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
243365004199	RHS Repeat; Region: RHS_repeat; cl11982
243365004200	RHS protein; Region: RHS; pfam03527
243365004201	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
243365004202	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
243365004203	RHS Repeat; Region: RHS_repeat; pfam05593
243365004204	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
243365004205	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
243365004206	RHS Repeat; Region: RHS_repeat; pfam05593
243365004207	RHS Repeat; Region: RHS_repeat; pfam05593
243365004208	RHS Repeat; Region: RHS_repeat; pfam05593
243365004209	RHS Repeat; Region: RHS_repeat; pfam05593
243365004210	RHS Repeat; Region: RHS_repeat; pfam05593
243365004211	RHS Repeat; Region: RHS_repeat; cl11982
243365004212	RHS protein; Region: RHS; pfam03527
243365004213	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
243365004214	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
243365004215	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
243365004216	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
243365004217	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
243365004218	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
243365004219	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
243365004220	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365004221	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365004222	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
243365004223	dimerization interface [polypeptide binding]; other site
243365004224	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
243365004225	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
243365004226	inhibitor-cofactor binding pocket; inhibition site
243365004227	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365004228	catalytic residue [active]
243365004229	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
243365004230	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
243365004231	tetrameric interface [polypeptide binding]; other site
243365004232	NAD binding site [chemical binding]; other site
243365004233	catalytic residues [active]
243365004234	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365004235	Coenzyme A binding pocket [chemical binding]; other site
243365004236	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895
243365004237	putative hydrophobic ligand binding site [chemical binding]; other site
243365004238	PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain.  Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543
243365004239	active site
243365004240	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
243365004241	aromatic chitin/cellulose binding site residues [chemical binding]; other site
243365004242	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
243365004243	aromatic chitin/cellulose binding site residues [chemical binding]; other site
243365004244	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
243365004245	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
243365004246	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
243365004247	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
243365004248	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
243365004249	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
243365004250	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
243365004251	active site
243365004252	dimer interface [polypeptide binding]; other site
243365004253	effector binding site; other site
243365004254	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
243365004255	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
243365004256	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
243365004257	ligand binding site [chemical binding]; other site
243365004258	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
243365004259	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
243365004260	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
243365004261	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
243365004262	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
243365004263	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
243365004264	DNA-binding site [nucleotide binding]; DNA binding site
243365004265	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
243365004266	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365004267	homodimer interface [polypeptide binding]; other site
243365004268	catalytic residue [active]
243365004269	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
243365004270	4Fe-4S binding domain; Region: Fer4_5; pfam12801
243365004271	4Fe-4S binding domain; Region: Fer4; pfam00037
243365004272	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
243365004273	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
243365004274	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365004275	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
243365004276	putative active site [active]
243365004277	heme pocket [chemical binding]; other site
243365004278	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365004279	putative active site [active]
243365004280	heme pocket [chemical binding]; other site
243365004281	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365004282	dimer interface [polypeptide binding]; other site
243365004283	putative CheW interface [polypeptide binding]; other site
243365004284	MarC family integral membrane protein; Region: MarC; cl00919
243365004285	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
243365004286	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
243365004287	metal binding site [ion binding]; metal-binding site
243365004288	dimer interface [polypeptide binding]; other site
243365004289	ArsC family; Region: ArsC; pfam03960
243365004290	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
243365004291	putative catalytic residues [active]
243365004292	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
243365004293	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
243365004294	Walker A motif; other site
243365004295	ATP binding site [chemical binding]; other site
243365004296	Walker B motif; other site
243365004297	Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059
243365004298	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
243365004299	acyl-activating enzyme (AAE) consensus motif; other site
243365004300	putative AMP binding site [chemical binding]; other site
243365004301	putative active site [active]
243365004302	putative CoA binding site [chemical binding]; other site
243365004303	ribosome maturation protein RimP; Reviewed; Region: PRK00092
243365004304	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
243365004305	putative oligomer interface [polypeptide binding]; other site
243365004306	putative RNA binding site [nucleotide binding]; other site
243365004307	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
243365004308	NusA N-terminal domain; Region: NusA_N; pfam08529
243365004309	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
243365004310	RNA binding site [nucleotide binding]; other site
243365004311	homodimer interface [polypeptide binding]; other site
243365004312	NusA-like KH domain; Region: KH_5; pfam13184
243365004313	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
243365004314	G-X-X-G motif; other site
243365004315	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
243365004316	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
243365004317	translation initiation factor IF-2; Region: IF-2; TIGR00487
243365004318	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
243365004319	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
243365004320	G1 box; other site
243365004321	putative GEF interaction site [polypeptide binding]; other site
243365004322	GTP/Mg2+ binding site [chemical binding]; other site
243365004323	Switch I region; other site
243365004324	G2 box; other site
243365004325	G3 box; other site
243365004326	Switch II region; other site
243365004327	G4 box; other site
243365004328	G5 box; other site
243365004329	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
243365004330	Translation-initiation factor 2; Region: IF-2; pfam11987
243365004331	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
243365004332	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
243365004333	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
243365004334	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
243365004335	RNA binding site [nucleotide binding]; other site
243365004336	active site
243365004337	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
243365004338	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
243365004339	16S/18S rRNA binding site [nucleotide binding]; other site
243365004340	S13e-L30e interaction site [polypeptide binding]; other site
243365004341	25S rRNA binding site [nucleotide binding]; other site
243365004342	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
243365004343	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
243365004344	RNase E interface [polypeptide binding]; other site
243365004345	trimer interface [polypeptide binding]; other site
243365004346	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
243365004347	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
243365004348	RNase E interface [polypeptide binding]; other site
243365004349	trimer interface [polypeptide binding]; other site
243365004350	active site
243365004351	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
243365004352	putative nucleic acid binding region [nucleotide binding]; other site
243365004353	G-X-X-G motif; other site
243365004354	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
243365004355	RNA binding site [nucleotide binding]; other site
243365004356	domain interface; other site
243365004357	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
243365004358	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
243365004359	Surface antigen; Region: Bac_surface_Ag; pfam01103
243365004360	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
243365004361	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
243365004362	M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342
243365004363	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
243365004364	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
243365004365	Mor transcription activator family; Region: Mor; cl02360
243365004366	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
243365004367	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
243365004368	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
243365004369	2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331
243365004370	putative NAD(P) binding site [chemical binding]; other site
243365004371	active site
243365004372	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
243365004373	hydrophobic substrate binding pocket; other site
243365004374	Isochorismatase family; Region: Isochorismatase; pfam00857
243365004375	active site
243365004376	conserved cis-peptide bond; other site
243365004377	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
243365004378	enterobactin synthase subunit E; Provisional; Region: entE; PRK10946
243365004379	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
243365004380	acyl-activating enzyme (AAE) consensus motif; other site
243365004381	active site
243365004382	AMP binding site [chemical binding]; other site
243365004383	substrate binding site [chemical binding]; other site
243365004384	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
243365004385	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
243365004386	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
243365004387	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
243365004388	acyl-activating enzyme (AAE) consensus motif; other site
243365004389	AMP binding site [chemical binding]; other site
243365004390	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
243365004391	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
243365004392	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
243365004393	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
243365004394	Walker A/P-loop; other site
243365004395	ATP binding site [chemical binding]; other site
243365004396	Q-loop/lid; other site
243365004397	ABC transporter signature motif; other site
243365004398	Walker B; other site
243365004399	D-loop; other site
243365004400	H-loop/switch region; other site
243365004401	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
243365004402	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
243365004403	ABC-ATPase subunit  interface; other site
243365004404	dimer interface [polypeptide binding]; other site
243365004405	putative PBP binding regions; other site
243365004406	Periplasmic binding protein TroA_f.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139
243365004407	putative ligand binding residues [chemical binding]; other site
243365004408	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981
243365004409	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
243365004410	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
243365004411	N-terminal plug; other site
243365004412	ligand-binding site [chemical binding]; other site
243365004413	Putative carbohydrate binding domain; Region: CHB_HEX; smart01081
243365004414	N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525
243365004415	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569
243365004416	active site
243365004417	C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847
243365004418	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
243365004419	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365004420	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365004421	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
243365004422	dimerization interface [polypeptide binding]; other site
243365004423	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
243365004424	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
243365004425	inhibitor-cofactor binding pocket; inhibition site
243365004426	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365004427	catalytic residue [active]
243365004428	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
243365004429	arginine/ornithine succinyltransferase, alpha subunit; Region: arg_AOST_alph; TIGR03245
243365004430	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
243365004431	arginine N-succinyltransferase; Region: arg_catab_AstA; TIGR03244
243365004432	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
243365004433	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
243365004434	NAD(P) binding site [chemical binding]; other site
243365004435	catalytic residues [active]
243365004436	succinylarginine dihydrolase; Provisional; Region: PRK13281
243365004437	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
243365004438	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
243365004439	TM-ABC transporter signature motif; other site
243365004440	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
243365004441	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
243365004442	TM-ABC transporter signature motif; other site
243365004443	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
243365004444	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
243365004445	Walker A/P-loop; other site
243365004446	ATP binding site [chemical binding]; other site
243365004447	Q-loop/lid; other site
243365004448	ABC transporter signature motif; other site
243365004449	Walker B; other site
243365004450	D-loop; other site
243365004451	H-loop/switch region; other site
243365004452	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
243365004453	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
243365004454	Walker A/P-loop; other site
243365004455	ATP binding site [chemical binding]; other site
243365004456	Q-loop/lid; other site
243365004457	ABC transporter signature motif; other site
243365004458	Walker B; other site
243365004459	D-loop; other site
243365004460	H-loop/switch region; other site
243365004461	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243365004462	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243365004463	substrate binding pocket [chemical binding]; other site
243365004464	membrane-bound complex binding site; other site
243365004465	hinge residues; other site
243365004466	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
243365004467	Uncharacterized conserved protein [Function unknown]; Region: COG1434
243365004468	putative active site [active]
243365004469	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
243365004470	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365004471	putative substrate translocation pore; other site
243365004472	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
243365004473	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
243365004474	Alkaline phosphatase homologues; Region: alkPPc; smart00098
243365004475	active site
243365004476	dimer interface [polypeptide binding]; other site
243365004477	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
243365004478	Alkaline phosphatase homologues; Region: alkPPc; smart00098
243365004479	active site
243365004480	dimer interface [polypeptide binding]; other site
243365004481	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
243365004482	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243365004483	Zn2+ binding site [ion binding]; other site
243365004484	Mg2+ binding site [ion binding]; other site
243365004485	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
243365004486	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
243365004487	ATP binding site [chemical binding]; other site
243365004488	putative Mg++ binding site [ion binding]; other site
243365004489	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243365004490	nucleotide binding region [chemical binding]; other site
243365004491	Helicase associated domain (HA2); Region: HA2; pfam04408
243365004492	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
243365004493	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
243365004494	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
243365004495	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
243365004496	DNA-binding site [nucleotide binding]; DNA binding site
243365004497	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
243365004498	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365004499	homodimer interface [polypeptide binding]; other site
243365004500	catalytic residue [active]
243365004501	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
243365004502	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
243365004503	tetramer interface [polypeptide binding]; other site
243365004504	active site
243365004505	Mg2+/Mn2+ binding site [ion binding]; other site
243365004506	Uncharacterized conserved protein [Function unknown]; Region: COG2128
243365004507	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
243365004508	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365004509	ATP binding site [chemical binding]; other site
243365004510	Mg2+ binding site [ion binding]; other site
243365004511	G-X-G motif; other site
243365004512	Histidine kinase; Region: HisKA_3; pfam07730
243365004513	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
243365004514	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365004515	active site
243365004516	phosphorylation site [posttranslational modification]
243365004517	intermolecular recognition site; other site
243365004518	dimerization interface [polypeptide binding]; other site
243365004519	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
243365004520	DNA binding residues [nucleotide binding]
243365004521	dimerization interface [polypeptide binding]; other site
243365004522	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243365004523	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365004524	dimer interface [polypeptide binding]; other site
243365004525	putative CheW interface [polypeptide binding]; other site
243365004526	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
243365004527	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
243365004528	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
243365004529	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
243365004530	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243365004531	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
243365004532	Predicted membrane protein [Function unknown]; Region: COG3766
243365004533	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
243365004534	phosphate acetyltransferase; Reviewed; Region: PRK05632
243365004535	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
243365004536	DRTGG domain; Region: DRTGG; pfam07085
243365004537	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
243365004538	propionate/acetate kinase; Provisional; Region: PRK12379
243365004539	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
243365004540	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
243365004541	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
243365004542	[2Fe-2S] cluster binding site [ion binding]; other site
243365004543	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
243365004544	alpha subunit interface [polypeptide binding]; other site
243365004545	active site
243365004546	substrate binding site [chemical binding]; other site
243365004547	Fe binding site [ion binding]; other site
243365004548	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
243365004549	EamA-like transporter family; Region: EamA; pfam00892
243365004550	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
243365004551	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
243365004552	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
243365004553	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
243365004554	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
243365004555	RNA binding site [nucleotide binding]; other site
243365004556	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
243365004557	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
243365004558	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
243365004559	Glutamate binding site [chemical binding]; other site
243365004560	NAD binding site [chemical binding]; other site
243365004561	catalytic residues [active]
243365004562	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
243365004563	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
243365004564	dimerization interface [polypeptide binding]; other site
243365004565	ligand binding site [chemical binding]; other site
243365004566	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
243365004567	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
243365004568	dimer interface [polypeptide binding]; other site
243365004569	active site
243365004570	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
243365004571	active site
243365004572	catalytic site [active]
243365004573	Phosphopantetheine attachment site; Region: PP-binding; cl09936
243365004574	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
243365004575	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
243365004576	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
243365004577	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
243365004578	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243365004579	NAD(P) binding site [chemical binding]; other site
243365004580	active site
243365004581	Ferredoxin [Energy production and conversion]; Region: COG1146
243365004582	4Fe-4S binding domain; Region: Fer4; pfam00037
243365004583	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
243365004584	Protein of unknown function (DUF3995); Region: DUF3995; pfam13160
243365004585	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
243365004586	Domain of unknown function (DUF4180); Region: DUF4180; pfam13788
243365004587	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
243365004588	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
243365004589	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
243365004590	substrate binding site [chemical binding]; other site
243365004591	oxyanion hole (OAH) forming residues; other site
243365004592	trimer interface [polypeptide binding]; other site
243365004593	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
243365004594	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
243365004595	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
243365004596	putative FMN binding site [chemical binding]; other site
243365004597	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
243365004598	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
243365004599	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
243365004600	catalytic triad [active]
243365004601	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
243365004602	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
243365004603	Walker A motif; other site
243365004604	homodimer interface [polypeptide binding]; other site
243365004605	ATP binding site [chemical binding]; other site
243365004606	hydroxycobalamin binding site [chemical binding]; other site
243365004607	Walker B motif; other site
243365004608	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
243365004609	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
243365004610	ABC-ATPase subunit  interface; other site
243365004611	dimer interface [polypeptide binding]; other site
243365004612	putative PBP binding regions; other site
243365004613	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
243365004614	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
243365004615	putative ligand binding residues [chemical binding]; other site
243365004616	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
243365004617	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243365004618	Walker A/P-loop; other site
243365004619	ATP binding site [chemical binding]; other site
243365004620	Q-loop/lid; other site
243365004621	ABC transporter signature motif; other site
243365004622	Walker B; other site
243365004623	H-loop/switch region; other site
243365004624	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
243365004625	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
243365004626	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
243365004627	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
243365004628	active site
243365004629	SAM binding site [chemical binding]; other site
243365004630	homodimer interface [polypeptide binding]; other site
243365004631	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922
243365004632	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
243365004633	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
243365004634	cobalamin biosynthesis protein CbiG; Provisional; Region: PRK07027
243365004635	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
243365004636	active site
243365004637	SAM binding site [chemical binding]; other site
243365004638	homodimer interface [polypeptide binding]; other site
243365004639	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
243365004640	active site
243365004641	SAM binding site [chemical binding]; other site
243365004642	homodimer interface [polypeptide binding]; other site
243365004643	Cobalamin biosynthesis protein CbiD [Coenzyme metabolism]; Region: CbiD; COG1903
243365004644	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
243365004645	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
243365004646	putative active site [active]
243365004647	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
243365004648	putative active site [active]
243365004649	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
243365004650	Precorrin-8X methylmutase; Region: CbiC; pfam02570
243365004651	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
243365004652	active site
243365004653	putative homodimer interface [polypeptide binding]; other site
243365004654	SAM binding site [chemical binding]; other site
243365004655	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
243365004656	active site
243365004657	SAM binding site [chemical binding]; other site
243365004658	homodimer interface [polypeptide binding]; other site
243365004659	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
243365004660	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
243365004661	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
243365004662	metal ion-dependent adhesion site (MIDAS); other site
243365004663	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
243365004664	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
243365004665	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
243365004666	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
243365004667	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
243365004668	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
243365004669	dimer interface [polypeptide binding]; other site
243365004670	[2Fe-2S] cluster binding site [ion binding]; other site
243365004671	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
243365004672	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
243365004673	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
243365004674	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365004675	homodimer interface [polypeptide binding]; other site
243365004676	catalytic residue [active]
243365004677	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
243365004678	cobyric acid synthase; Provisional; Region: PRK00784
243365004679	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
243365004680	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
243365004681	catalytic triad [active]
243365004682	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
243365004683	active site
243365004684	Response regulator receiver domain; Region: Response_reg; pfam00072
243365004685	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365004686	active site
243365004687	phosphorylation site [posttranslational modification]
243365004688	intermolecular recognition site; other site
243365004689	dimerization interface [polypeptide binding]; other site
243365004690	PAS domain S-box; Region: sensory_box; TIGR00229
243365004691	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365004692	putative active site [active]
243365004693	heme pocket [chemical binding]; other site
243365004694	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365004695	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365004696	metal binding site [ion binding]; metal-binding site
243365004697	active site
243365004698	I-site; other site
243365004699	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243365004700	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
243365004701	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
243365004702	GAF domain; Region: GAF_3; pfam13492
243365004703	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243365004704	dimer interface [polypeptide binding]; other site
243365004705	phosphorylation site [posttranslational modification]
243365004706	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365004707	ATP binding site [chemical binding]; other site
243365004708	Mg2+ binding site [ion binding]; other site
243365004709	G-X-G motif; other site
243365004710	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365004711	active site
243365004712	phosphorylation site [posttranslational modification]
243365004713	intermolecular recognition site; other site
243365004714	dimerization interface [polypeptide binding]; other site
243365004715	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365004716	Response regulator receiver domain; Region: Response_reg; pfam00072
243365004717	active site
243365004718	phosphorylation site [posttranslational modification]
243365004719	intermolecular recognition site; other site
243365004720	dimerization interface [polypeptide binding]; other site
243365004721	CheB methylesterase; Region: CheB_methylest; pfam01339
243365004722	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
243365004723	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
243365004724	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
243365004725	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243365004726	dimer interface [polypeptide binding]; other site
243365004727	phosphorylation site [posttranslational modification]
243365004728	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365004729	ATP binding site [chemical binding]; other site
243365004730	Mg2+ binding site [ion binding]; other site
243365004731	G-X-G motif; other site
243365004732	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
243365004733	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365004734	active site
243365004735	phosphorylation site [posttranslational modification]
243365004736	intermolecular recognition site; other site
243365004737	dimerization interface [polypeptide binding]; other site
243365004738	Response regulator receiver domain; Region: Response_reg; pfam00072
243365004739	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365004740	active site
243365004741	phosphorylation site [posttranslational modification]
243365004742	intermolecular recognition site; other site
243365004743	dimerization interface [polypeptide binding]; other site
243365004744	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
243365004745	putative binding surface; other site
243365004746	active site
243365004747	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365004748	PAS fold; Region: PAS_3; pfam08447
243365004749	putative active site [active]
243365004750	heme pocket [chemical binding]; other site
243365004751	PAS domain; Region: PAS_9; pfam13426
243365004752	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365004753	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365004754	metal binding site [ion binding]; metal-binding site
243365004755	active site
243365004756	I-site; other site
243365004757	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08690
243365004758	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
243365004759	NAD binding site [chemical binding]; other site
243365004760	homotetramer interface [polypeptide binding]; other site
243365004761	homodimer interface [polypeptide binding]; other site
243365004762	substrate binding site [chemical binding]; other site
243365004763	active site
243365004764	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
243365004765	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
243365004766	catalytic residues [active]
243365004767	transcription termination factor Rho; Provisional; Region: rho; PRK09376
243365004768	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
243365004769	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
243365004770	RNA binding site [nucleotide binding]; other site
243365004771	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
243365004772	multimer interface [polypeptide binding]; other site
243365004773	Walker A motif; other site
243365004774	ATP binding site [chemical binding]; other site
243365004775	Walker B motif; other site
243365004776	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
243365004777	putative active site [active]
243365004778	putative CoA binding site [chemical binding]; other site
243365004779	nudix motif; other site
243365004780	metal binding site [ion binding]; metal-binding site
243365004781	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365004782	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365004783	metal binding site [ion binding]; metal-binding site
243365004784	active site
243365004785	I-site; other site
243365004786	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978
243365004787	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
243365004788	dimerization interface [polypeptide binding]; other site
243365004789	active site
243365004790	Predicted membrane protein [Function unknown]; Region: COG3235
243365004791	MAPEG family; Region: MAPEG; cl09190
243365004792	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
243365004793	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243365004794	motif II; other site
243365004795	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
243365004796	FAD binding domain; Region: FAD_binding_4; pfam01565
243365004797	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
243365004798	multidrug efflux protein; Reviewed; Region: PRK01766
243365004799	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
243365004800	cation binding site [ion binding]; other site
243365004801	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
243365004802	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365004803	active site
243365004804	phosphorylation site [posttranslational modification]
243365004805	intermolecular recognition site; other site
243365004806	dimerization interface [polypeptide binding]; other site
243365004807	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
243365004808	DNA binding site [nucleotide binding]
243365004809	sensor protein KdpD; Provisional; Region: PRK10490
243365004810	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
243365004811	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
243365004812	Ligand Binding Site [chemical binding]; other site
243365004813	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
243365004814	GAF domain; Region: GAF_3; pfam13492
243365004815	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243365004816	dimer interface [polypeptide binding]; other site
243365004817	phosphorylation site [posttranslational modification]
243365004818	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365004819	ATP binding site [chemical binding]; other site
243365004820	Mg2+ binding site [ion binding]; other site
243365004821	G-X-G motif; other site
243365004822	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
243365004823	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
243365004824	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
243365004825	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
243365004826	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
243365004827	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243365004828	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
243365004829	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365004830	Coenzyme A binding pocket [chemical binding]; other site
243365004831	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
243365004832	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
243365004833	motif 1; other site
243365004834	active site
243365004835	motif 2; other site
243365004836	motif 3; other site
243365004837	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
243365004838	DHHA1 domain; Region: DHHA1; pfam02272
243365004839	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822
243365004840	putative hydrophobic ligand binding site [chemical binding]; other site
243365004841	recombination regulator RecX; Reviewed; Region: recX; PRK00117
243365004842	recombinase A; Provisional; Region: recA; PRK09354
243365004843	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
243365004844	hexamer interface [polypeptide binding]; other site
243365004845	Walker A motif; other site
243365004846	ATP binding site [chemical binding]; other site
243365004847	Walker B motif; other site
243365004848	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
243365004849	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
243365004850	Transglycosylase SLT domain; Region: SLT_2; pfam13406
243365004851	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
243365004852	N-acetyl-D-glucosamine binding site [chemical binding]; other site
243365004853	catalytic residue [active]
243365004854	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
243365004855	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243365004856	Walker A motif; other site
243365004857	ATP binding site [chemical binding]; other site
243365004858	Walker B motif; other site
243365004859	arginine finger; other site
243365004860	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
243365004861	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
243365004862	hypothetical protein; Validated; Region: PRK00153
243365004863	recombination protein RecR; Reviewed; Region: recR; PRK00076
243365004864	RecR protein; Region: RecR; pfam02132
243365004865	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
243365004866	putative active site [active]
243365004867	putative metal-binding site [ion binding]; other site
243365004868	tetramer interface [polypeptide binding]; other site
243365004869	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365004870	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
243365004871	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
243365004872	NAD synthetase; Provisional; Region: PRK13981
243365004873	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
243365004874	multimer interface [polypeptide binding]; other site
243365004875	active site
243365004876	catalytic triad [active]
243365004877	protein interface 1 [polypeptide binding]; other site
243365004878	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
243365004879	homodimer interface [polypeptide binding]; other site
243365004880	NAD binding pocket [chemical binding]; other site
243365004881	ATP binding pocket [chemical binding]; other site
243365004882	Mg binding site [ion binding]; other site
243365004883	active-site loop [active]
243365004884	Protein of unknown function, DUF482; Region: DUF482; pfam04339
243365004885	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
243365004886	Common central domain of tyrosinase; Region: Tyrosinase; pfam00264
243365004887	Response regulator receiver domain; Region: Response_reg; pfam00072
243365004888	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365004889	active site
243365004890	phosphorylation site [posttranslational modification]
243365004891	intermolecular recognition site; other site
243365004892	dimerization interface [polypeptide binding]; other site
243365004893	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
243365004894	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365004895	putative active site [active]
243365004896	heme pocket [chemical binding]; other site
243365004897	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365004898	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365004899	metal binding site [ion binding]; metal-binding site
243365004900	active site
243365004901	I-site; other site
243365004902	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243365004903	CHASE domain; Region: CHASE; pfam03924
243365004904	PAS domain S-box; Region: sensory_box; TIGR00229
243365004905	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365004906	putative active site [active]
243365004907	heme pocket [chemical binding]; other site
243365004908	PAS fold; Region: PAS_4; pfam08448
243365004909	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365004910	PAS domain; Region: PAS_9; pfam13426
243365004911	putative active site [active]
243365004912	heme pocket [chemical binding]; other site
243365004913	PAS domain S-box; Region: sensory_box; TIGR00229
243365004914	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365004915	putative active site [active]
243365004916	heme pocket [chemical binding]; other site
243365004917	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365004918	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243365004919	putative active site [active]
243365004920	heme pocket [chemical binding]; other site
243365004921	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243365004922	dimer interface [polypeptide binding]; other site
243365004923	phosphorylation site [posttranslational modification]
243365004924	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365004925	ATP binding site [chemical binding]; other site
243365004926	Mg2+ binding site [ion binding]; other site
243365004927	G-X-G motif; other site
243365004928	Response regulator receiver domain; Region: Response_reg; pfam00072
243365004929	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365004930	active site
243365004931	phosphorylation site [posttranslational modification]
243365004932	intermolecular recognition site; other site
243365004933	dimerization interface [polypeptide binding]; other site
243365004934	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
243365004935	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365004936	active site
243365004937	phosphorylation site [posttranslational modification]
243365004938	intermolecular recognition site; other site
243365004939	dimerization interface [polypeptide binding]; other site
243365004940	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
243365004941	putative binding surface; other site
243365004942	active site
243365004943	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
243365004944	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
243365004945	putative molybdopterin cofactor binding site [chemical binding]; other site
243365004946	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
243365004947	putative molybdopterin cofactor binding site; other site
243365004948	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
243365004949	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
243365004950	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
243365004951	GTP binding site; other site
243365004952	multidrug efflux protein; Reviewed; Region: PRK09579
243365004953	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
243365004954	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
243365004955	HlyD family secretion protein; Region: HlyD_3; pfam13437
243365004956	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
243365004957	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
243365004958	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
243365004959	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
243365004960	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
243365004961	putative NAD(P) binding site [chemical binding]; other site
243365004962	dimer interface [polypeptide binding]; other site
243365004963	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365004964	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365004965	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
243365004966	putative effector binding pocket; other site
243365004967	dimerization interface [polypeptide binding]; other site
243365004968	poly(A) polymerase; Region: pcnB; TIGR01942
243365004969	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
243365004970	active site
243365004971	NTP binding site [chemical binding]; other site
243365004972	metal binding triad [ion binding]; metal-binding site
243365004973	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
243365004974	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
243365004975	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
243365004976	catalytic center binding site [active]
243365004977	ATP binding site [chemical binding]; other site
243365004978	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
243365004979	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
243365004980	Substrate-binding site [chemical binding]; other site
243365004981	Substrate specificity [chemical binding]; other site
243365004982	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
243365004983	oligomerization interface [polypeptide binding]; other site
243365004984	active site
243365004985	metal binding site [ion binding]; metal-binding site
243365004986	pantoate--beta-alanine ligase; Region: panC; TIGR00018
243365004987	Pantoate-beta-alanine ligase; Region: PanC; cd00560
243365004988	active site
243365004989	ATP-binding site [chemical binding]; other site
243365004990	pantoate-binding site; other site
243365004991	HXXH motif; other site
243365004992	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
243365004993	tetramerization interface [polypeptide binding]; other site
243365004994	active site
243365004995	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243365004996	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243365004997	substrate binding pocket [chemical binding]; other site
243365004998	membrane-bound complex binding site; other site
243365004999	hinge residues; other site
243365005000	Uncharacterized conserved protein [Function unknown]; Region: COG3791
243365005001	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
243365005002	isocitrate lyase; Provisional; Region: PRK15063
243365005003	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
243365005004	tetramer interface [polypeptide binding]; other site
243365005005	active site
243365005006	Mg2+/Mn2+ binding site [ion binding]; other site
243365005007	heat shock protein GrpE; Provisional; Region: PRK14140
243365005008	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
243365005009	dimer interface [polypeptide binding]; other site
243365005010	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
243365005011	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
243365005012	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
243365005013	nucleotide binding site [chemical binding]; other site
243365005014	NEF interaction site [polypeptide binding]; other site
243365005015	SBD interface [polypeptide binding]; other site
243365005016	Fatty acid desaturase; Region: FA_desaturase; pfam00487
243365005017	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
243365005018	putative di-iron ligands [ion binding]; other site
243365005019	chaperone protein DnaJ; Provisional; Region: PRK10767
243365005020	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
243365005021	HSP70 interaction site [polypeptide binding]; other site
243365005022	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
243365005023	substrate binding site [polypeptide binding]; other site
243365005024	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
243365005025	Zn binding sites [ion binding]; other site
243365005026	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
243365005027	dimer interface [polypeptide binding]; other site
243365005028	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
243365005029	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
243365005030	trimer interface [polypeptide binding]; other site
243365005031	eyelet of channel; other site
243365005032	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
243365005033	dimer interface [polypeptide binding]; other site
243365005034	allosteric magnesium binding site [ion binding]; other site
243365005035	active site
243365005036	aspartate-rich active site metal binding site; other site
243365005037	Schiff base residues; other site
243365005038	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
243365005039	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
243365005040	substrate-cofactor binding pocket; other site
243365005041	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365005042	catalytic residue [active]
243365005043	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
243365005044	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
243365005045	NAD(P) binding site [chemical binding]; other site
243365005046	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365005047	dimer interface [polypeptide binding]; other site
243365005048	putative CheW interface [polypeptide binding]; other site
243365005049	Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232
243365005050	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
243365005051	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
243365005052	dimer interface [polypeptide binding]; other site
243365005053	motif 1; other site
243365005054	active site
243365005055	motif 2; other site
243365005056	motif 3; other site
243365005057	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
243365005058	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
243365005059	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
243365005060	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243365005061	active site
243365005062	motif I; other site
243365005063	motif II; other site
243365005064	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
243365005065	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
243365005066	putative acyl-acceptor binding pocket; other site
243365005067	Protein of unknown function DUF45; Region: DUF45; pfam01863
243365005068	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
243365005069	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
243365005070	dimer interface [polypeptide binding]; other site
243365005071	active site
243365005072	metal binding site [ion binding]; metal-binding site
243365005073	glutathione binding site [chemical binding]; other site
243365005074	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
243365005075	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
243365005076	transmembrane helices; other site
243365005077	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
243365005078	Carbon starvation protein CstA; Region: CstA; pfam02554
243365005079	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
243365005080	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
243365005081	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365005082	active site
243365005083	phosphorylation site [posttranslational modification]
243365005084	intermolecular recognition site; other site
243365005085	dimerization interface [polypeptide binding]; other site
243365005086	LytTr DNA-binding domain; Region: LytTR; smart00850
243365005087	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
243365005088	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
243365005089	GAF domain; Region: GAF; pfam01590
243365005090	Histidine kinase; Region: His_kinase; pfam06580
243365005091	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365005092	ATP binding site [chemical binding]; other site
243365005093	Mg2+ binding site [ion binding]; other site
243365005094	G-X-G motif; other site
243365005095	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
243365005096	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
243365005097	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
243365005098	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
243365005099	PAS domain; Region: PAS_9; pfam13426
243365005100	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
243365005101	putative active site [active]
243365005102	heme pocket [chemical binding]; other site
243365005103	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365005104	metal binding site [ion binding]; metal-binding site
243365005105	active site
243365005106	I-site; other site
243365005107	Protein of unknown function (DUF3465); Region: DUF3465; pfam11948
243365005108	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
243365005109	Na2 binding site [ion binding]; other site
243365005110	putative substrate binding site 1 [chemical binding]; other site
243365005111	Na binding site 1 [ion binding]; other site
243365005112	putative substrate binding site 2 [chemical binding]; other site
243365005113	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243365005114	substrate binding pocket [chemical binding]; other site
243365005115	membrane-bound complex binding site; other site
243365005116	hinge residues; other site
243365005117	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
243365005118	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
243365005119	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
243365005120	catalytic loop [active]
243365005121	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
243365005122	iron binding site [ion binding]; other site
243365005123	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
243365005124	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
243365005125	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
243365005126	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
243365005127	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
243365005128	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
243365005129	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
243365005130	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
243365005131	XdhC Rossmann domain; Region: XdhC_C; pfam13478
243365005132	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
243365005133	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365005134	dimer interface [polypeptide binding]; other site
243365005135	putative CheW interface [polypeptide binding]; other site
243365005136	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
243365005137	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243365005138	Walker A/P-loop; other site
243365005139	ATP binding site [chemical binding]; other site
243365005140	Q-loop/lid; other site
243365005141	ABC transporter signature motif; other site
243365005142	Walker B; other site
243365005143	D-loop; other site
243365005144	H-loop/switch region; other site
243365005145	TOBE domain; Region: TOBE_2; pfam08402
243365005146	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
243365005147	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365005148	dimer interface [polypeptide binding]; other site
243365005149	conserved gate region; other site
243365005150	putative PBP binding loops; other site
243365005151	ABC-ATPase subunit interface; other site
243365005152	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4132
243365005153	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
243365005154	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
243365005155	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
243365005156	hydroxyglutarate oxidase; Provisional; Region: PRK11728
243365005157	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
243365005158	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
243365005159	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
243365005160	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
243365005161	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
243365005162	active site
243365005163	homodimer interface [polypeptide binding]; other site
243365005164	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
243365005165	AAA domain; Region: AAA_28; pfam13521
243365005166	S4 domain; Region: S4_2; pfam13275
243365005167	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
243365005168	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
243365005169	active site
243365005170	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
243365005171	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
243365005172	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
243365005173	active site
243365005174	putative substrate binding region [chemical binding]; other site
243365005175	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
243365005176	Peptidase family M50; Region: Peptidase_M50; pfam02163
243365005177	active site
243365005178	putative substrate binding region [chemical binding]; other site
243365005179	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
243365005180	active site
243365005181	HIGH motif; other site
243365005182	dimer interface [polypeptide binding]; other site
243365005183	KMSKS motif; other site
243365005184	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365005185	PAS domain; Region: PAS_9; pfam13426
243365005186	putative active site [active]
243365005187	heme pocket [chemical binding]; other site
243365005188	PAS domain; Region: PAS_9; pfam13426
243365005189	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365005190	putative active site [active]
243365005191	heme pocket [chemical binding]; other site
243365005192	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365005193	dimer interface [polypeptide binding]; other site
243365005194	putative CheW interface [polypeptide binding]; other site
243365005195	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
243365005196	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
243365005197	N-terminal plug; other site
243365005198	ligand-binding site [chemical binding]; other site
243365005199	SAF-like; Region: SAF_2; pfam13144
243365005200	flagella basal body P-ring formation protein FlgA; Region: flgA_cterm; TIGR03170
243365005201	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
243365005202	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK12685
243365005203	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK06802
243365005204	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
243365005205	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
243365005206	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
243365005207	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
243365005208	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
243365005209	flagellar hook protein FlgE; Validated; Region: flgE; PRK06803
243365005210	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
243365005211	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
243365005212	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
243365005213	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
243365005214	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
243365005215	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
243365005216	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12694
243365005217	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
243365005218	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
243365005219	Flagellar L-ring protein; Region: FlgH; pfam02107
243365005220	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
243365005221	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
243365005222	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191
243365005223	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
243365005224	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192
243365005225	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
243365005226	Putative catalytic domain, repeat 1, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_1; cd09106
243365005227	PLD-like domain; Region: PLDc_2; pfam13091
243365005228	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
243365005229	putative active site [active]
243365005230	putative active site [active]
243365005231	catalytic site [active]
243365005232	putative catalytic site [active]
243365005233	Putative catalytic domain, repeat 2, of vertebrate phospholipases, PLD3, PLD4 and PLD5, viral envelope proteins K4 and p37, and similar proteins; Region: PLDc_vPLD3_4_5_like_2; cd09107
243365005234	PLD-like domain; Region: PLDc_2; pfam13091
243365005235	putative active site [active]
243365005236	putative catalytic site [active]
243365005237	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
243365005238	active site
243365005239	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
243365005240	dimer interface [polypeptide binding]; other site
243365005241	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
243365005242	Ligand Binding Site [chemical binding]; other site
243365005243	Molecular Tunnel; other site
243365005244	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
243365005245	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
243365005246	putative DNA binding site [nucleotide binding]; other site
243365005247	putative Zn2+ binding site [ion binding]; other site
243365005248	AsnC family; Region: AsnC_trans_reg; pfam01037
243365005249	Cache domain; Region: Cache_1; pfam02743
243365005250	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243365005251	dimerization interface [polypeptide binding]; other site
243365005252	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365005253	dimer interface [polypeptide binding]; other site
243365005254	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
243365005255	putative CheW interface [polypeptide binding]; other site
243365005256	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243365005257	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243365005258	dimer interface [polypeptide binding]; other site
243365005259	phosphorylation site [posttranslational modification]
243365005260	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365005261	ATP binding site [chemical binding]; other site
243365005262	Mg2+ binding site [ion binding]; other site
243365005263	G-X-G motif; other site
243365005264	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365005265	Response regulator receiver domain; Region: Response_reg; pfam00072
243365005266	active site
243365005267	phosphorylation site [posttranslational modification]
243365005268	intermolecular recognition site; other site
243365005269	dimerization interface [polypeptide binding]; other site
243365005270	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
243365005271	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
243365005272	putative transporter; Provisional; Region: PRK11660
243365005273	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
243365005274	Sulfate transporter family; Region: Sulfate_transp; pfam00916
243365005275	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
243365005276	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
243365005277	bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469
243365005278	putative ligand binding site [chemical binding]; other site
243365005279	NAD binding site [chemical binding]; other site
243365005280	dimerization interface [polypeptide binding]; other site
243365005281	catalytic site [active]
243365005282	Uncharacterized protein conserved in archaea [Function unknown]; Region: COG4030
243365005283	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
243365005284	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
243365005285	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
243365005286	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243365005287	active site
243365005288	motif I; other site
243365005289	motif II; other site
243365005290	HD domain; Region: HD_5; pfam13487
243365005291	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
243365005292	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243365005293	Zn2+ binding site [ion binding]; other site
243365005294	Mg2+ binding site [ion binding]; other site
243365005295	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
243365005296	Uncharacterized conserved protein [Function unknown]; Region: COG0397
243365005297	hypothetical protein; Validated; Region: PRK00029
243365005298	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
243365005299	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
243365005300	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
243365005301	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243365005302	Walker A/P-loop; other site
243365005303	ATP binding site [chemical binding]; other site
243365005304	Q-loop/lid; other site
243365005305	ABC transporter signature motif; other site
243365005306	Walker B; other site
243365005307	D-loop; other site
243365005308	H-loop/switch region; other site
243365005309	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
243365005310	Peptidase family M23; Region: Peptidase_M23; pfam01551
243365005311	HlyD family secretion protein; Region: HlyD_3; pfam13437
243365005312	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
243365005313	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
243365005314	hypothetical protein; Provisional; Region: PRK01254
243365005315	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
243365005316	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
243365005317	3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004
243365005318	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
243365005319	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
243365005320	Methyltransferase domain; Region: Methyltransf_23; pfam13489
243365005321	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365005322	S-adenosylmethionine binding site [chemical binding]; other site
243365005323	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
243365005324	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
243365005325	active site
243365005326	HIGH motif; other site
243365005327	nucleotide binding site [chemical binding]; other site
243365005328	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
243365005329	active site
243365005330	KMSKS motif; other site
243365005331	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
243365005332	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
243365005333	Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405
243365005334	active site
243365005335	metal binding site [ion binding]; metal-binding site
243365005336	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
243365005337	Fucose-binding lectin II (PA-IIL); Region: PA-IIL; pfam07472
243365005338	6-phosphofructokinase; Provisional; Region: PRK14072
243365005339	active site
243365005340	ADP/pyrophosphate binding site [chemical binding]; other site
243365005341	fructose-1,6-bisphosphate binding site; other site
243365005342	dimerization interface [polypeptide binding]; other site
243365005343	allosteric effector site; other site
243365005344	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
243365005345	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
243365005346	active site
243365005347	HIGH motif; other site
243365005348	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
243365005349	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
243365005350	KMSKS motif; other site
243365005351	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
243365005352	tRNA binding surface [nucleotide binding]; other site
243365005353	anticodon binding site; other site
243365005354	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
243365005355	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
243365005356	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
243365005357	CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09674
243365005358	CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737
243365005359	CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09676
243365005360	CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cd09675
243365005361	CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673
243365005362	CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562
243365005363	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
243365005364	HDOD domain; Region: HDOD; pfam08668
243365005365	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
243365005366	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
243365005367	acyl-activating enzyme (AAE) consensus motif; other site
243365005368	putative AMP binding site [chemical binding]; other site
243365005369	putative active site [active]
243365005370	putative CoA binding site [chemical binding]; other site
243365005371	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
243365005372	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
243365005373	active site
243365005374	catalytic residues [active]
243365005375	metal binding site [ion binding]; metal-binding site
243365005376	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
243365005377	TPR repeat; Region: TPR_11; pfam13414
243365005378	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243365005379	binding surface
243365005380	TPR motif; other site
243365005381	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
243365005382	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
243365005383	ATP-grasp domain; Region: ATP-grasp_4; cl17255
243365005384	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
243365005385	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
243365005386	carboxyltransferase (CT) interaction site; other site
243365005387	biotinylation site [posttranslational modification]; other site
243365005388	enoyl-CoA hydratase; Provisional; Region: PRK05995
243365005389	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
243365005390	substrate binding site [chemical binding]; other site
243365005391	oxyanion hole (OAH) forming residues; other site
243365005392	trimer interface [polypeptide binding]; other site
243365005393	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
243365005394	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
243365005395	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
243365005396	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
243365005397	isovaleryl-CoA dehydrogenase; Region: PLN02519
243365005398	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
243365005399	substrate binding site [chemical binding]; other site
243365005400	FAD binding site [chemical binding]; other site
243365005401	catalytic base [active]
243365005402	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
243365005403	nudix motif; other site
243365005404	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
243365005405	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
243365005406	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365005407	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
243365005408	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365005409	active site
243365005410	phosphorylation site [posttranslational modification]
243365005411	intermolecular recognition site; other site
243365005412	dimerization interface [polypeptide binding]; other site
243365005413	LytTr DNA-binding domain; Region: LytTR; pfam04397
243365005414	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
243365005415	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
243365005416	GAF domain; Region: GAF_3; pfam13492
243365005417	Histidine kinase; Region: His_kinase; pfam06580
243365005418	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365005419	ATP binding site [chemical binding]; other site
243365005420	Mg2+ binding site [ion binding]; other site
243365005421	G-X-G motif; other site
243365005422	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
243365005423	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
243365005424	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365005425	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365005426	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
243365005427	putative effector binding pocket; other site
243365005428	putative dimerization interface [polypeptide binding]; other site
243365005429	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
243365005430	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
243365005431	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
243365005432	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
243365005433	FAD binding pocket [chemical binding]; other site
243365005434	FAD binding motif [chemical binding]; other site
243365005435	phosphate binding motif [ion binding]; other site
243365005436	beta-alpha-beta structure motif; other site
243365005437	NAD binding pocket [chemical binding]; other site
243365005438	Heme binding  pocket [chemical binding]; other site
243365005439	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
243365005440	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
243365005441	catalytic loop [active]
243365005442	iron binding site [ion binding]; other site
243365005443	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
243365005444	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
243365005445	putative C-terminal domain interface [polypeptide binding]; other site
243365005446	putative GSH binding site (G-site) [chemical binding]; other site
243365005447	putative dimer interface [polypeptide binding]; other site
243365005448	C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206
243365005449	putative N-terminal domain interface [polypeptide binding]; other site
243365005450	putative dimer interface [polypeptide binding]; other site
243365005451	putative substrate binding pocket (H-site) [chemical binding]; other site
243365005452	MarR family; Region: MarR_2; cl17246
243365005453	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
243365005454	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
243365005455	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365005456	Coenzyme A binding pocket [chemical binding]; other site
243365005457	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
243365005458	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
243365005459	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
243365005460	DNA binding residues [nucleotide binding]
243365005461	putative dimer interface [polypeptide binding]; other site
243365005462	AMP-binding domain protein; Validated; Region: PRK08315
243365005463	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
243365005464	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
243365005465	acyl-activating enzyme (AAE) consensus motif; other site
243365005466	putative AMP binding site [chemical binding]; other site
243365005467	putative active site [active]
243365005468	putative CoA binding site [chemical binding]; other site
243365005469	Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173
243365005470	Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318
243365005471	SEC-C motif; Region: SEC-C; pfam02810
243365005472	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
243365005473	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
243365005474	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
243365005475	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
243365005476	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
243365005477	active site
243365005478	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
243365005479	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
243365005480	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
243365005481	dimer interface [polypeptide binding]; other site
243365005482	ADP-ribose binding site [chemical binding]; other site
243365005483	active site
243365005484	nudix motif; other site
243365005485	metal binding site [ion binding]; metal-binding site
243365005486	PilZ domain; Region: PilZ; pfam07238
243365005487	PrkA family serine protein kinase; Provisional; Region: PRK15455
243365005488	AAA ATPase domain; Region: AAA_16; pfam13191
243365005489	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
243365005490	hypothetical protein; Provisional; Region: PRK05325
243365005491	SpoVR family protein; Provisional; Region: PRK11767
243365005492	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
243365005493	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
243365005494	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
243365005495	Walker A/P-loop; other site
243365005496	ATP binding site [chemical binding]; other site
243365005497	Q-loop/lid; other site
243365005498	ABC transporter signature motif; other site
243365005499	Walker B; other site
243365005500	D-loop; other site
243365005501	H-loop/switch region; other site
243365005502	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
243365005503	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
243365005504	putative PBP binding regions; other site
243365005505	ABC-ATPase subunit  interface; other site
243365005506	dihydrodipicolinate reductase; Provisional; Region: PRK00048
243365005507	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
243365005508	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
243365005509	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
243365005510	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
243365005511	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
243365005512	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
243365005513	metal binding site 2 [ion binding]; metal-binding site
243365005514	putative DNA binding helix; other site
243365005515	metal binding site 1 [ion binding]; metal-binding site
243365005516	dimer interface [polypeptide binding]; other site
243365005517	structural Zn2+ binding site [ion binding]; other site
243365005518	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
243365005519	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
243365005520	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
243365005521	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
243365005522	Major Facilitator Superfamily; Region: MFS_1; pfam07690
243365005523	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365005524	putative substrate translocation pore; other site
243365005525	EthD domain; Region: EthD; pfam07110
243365005526	2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13029
243365005527	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
243365005528	dimer interface [polypeptide binding]; other site
243365005529	PYR/PP interface [polypeptide binding]; other site
243365005530	TPP binding site [chemical binding]; other site
243365005531	substrate binding site [chemical binding]; other site
243365005532	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
243365005533	TPP-binding site [chemical binding]; other site
243365005534	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
243365005535	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
243365005536	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
243365005537	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
243365005538	Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205
243365005539	homodimer interface [polypeptide binding]; other site
243365005540	substrate binding pocket [chemical binding]; other site
243365005541	catalytic residues [active]
243365005542	NADH/NADPH cofactor binding site [chemical binding]; other site
243365005543	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
243365005544	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
243365005545	ATP-grasp domain; Region: ATP-grasp_4; cl17255
243365005546	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
243365005547	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
243365005548	carboxyltransferase (CT) interaction site; other site
243365005549	biotinylation site [posttranslational modification]; other site
243365005550	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
243365005551	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
243365005552	MarR family; Region: MarR_2; pfam12802
243365005553	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
243365005554	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
243365005555	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
243365005556	quinone interaction residues [chemical binding]; other site
243365005557	active site
243365005558	catalytic residues [active]
243365005559	FMN binding site [chemical binding]; other site
243365005560	substrate binding site [chemical binding]; other site
243365005561	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
243365005562	putative FMN binding site [chemical binding]; other site
243365005563	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
243365005564	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
243365005565	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
243365005566	ligand binding site [chemical binding]; other site
243365005567	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
243365005568	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
243365005569	tandem repeat interface [polypeptide binding]; other site
243365005570	oligomer interface [polypeptide binding]; other site
243365005571	active site residues [active]
243365005572	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
243365005573	iron-sulfur cluster [ion binding]; other site
243365005574	[2Fe-2S] cluster binding site [ion binding]; other site
243365005575	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
243365005576	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243365005577	motif II; other site
243365005578	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
243365005579	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
243365005580	RNA binding surface [nucleotide binding]; other site
243365005581	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
243365005582	active site
243365005583	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
243365005584	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
243365005585	homodimer interface [polypeptide binding]; other site
243365005586	oligonucleotide binding site [chemical binding]; other site
243365005587	Ferritin-like; Region: Ferritin-like; pfam12902
243365005588	PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385
243365005589	active site
243365005590	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365005591	Major Facilitator Superfamily; Region: MFS_1; pfam07690
243365005592	putative substrate translocation pore; other site
243365005593	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
243365005594	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
243365005595	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
243365005596	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
243365005597	hypothetical protein; Provisional; Region: PRK07236
243365005598	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683
243365005599	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
243365005600	dimerization interface [polypeptide binding]; other site
243365005601	putative Zn2+ binding site [ion binding]; other site
243365005602	putative DNA binding site [nucleotide binding]; other site
243365005603	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
243365005604	substrate binding site [chemical binding]; other site
243365005605	dimerization interface [polypeptide binding]; other site
243365005606	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
243365005607	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
243365005608	Walker A/P-loop; other site
243365005609	ATP binding site [chemical binding]; other site
243365005610	Q-loop/lid; other site
243365005611	ABC transporter signature motif; other site
243365005612	Walker B; other site
243365005613	D-loop; other site
243365005614	H-loop/switch region; other site
243365005615	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
243365005616	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365005617	dimer interface [polypeptide binding]; other site
243365005618	conserved gate region; other site
243365005619	putative PBP binding loops; other site
243365005620	ABC-ATPase subunit interface; other site
243365005621	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
243365005622	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365005623	dimer interface [polypeptide binding]; other site
243365005624	conserved gate region; other site
243365005625	putative PBP binding loops; other site
243365005626	ABC-ATPase subunit interface; other site
243365005627	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
243365005628	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243365005629	substrate binding pocket [chemical binding]; other site
243365005630	membrane-bound complex binding site; other site
243365005631	hinge residues; other site
243365005632	EAL domain; Region: EAL; pfam00563
243365005633	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365005634	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
243365005635	Coenzyme A binding pocket [chemical binding]; other site
243365005636	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243365005637	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
243365005638	phosphonate degradation operons associated HDIG domain protein; Region: Phn-HD; TIGR03276
243365005639	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
243365005640	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
243365005641	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
243365005642	active site
243365005643	phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324
243365005644	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243365005645	Walker A/P-loop; other site
243365005646	ATP binding site [chemical binding]; other site
243365005647	Q-loop/lid; other site
243365005648	ABC transporter signature motif; other site
243365005649	Walker B; other site
243365005650	D-loop; other site
243365005651	H-loop/switch region; other site
243365005652	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
243365005653	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
243365005654	Walker A/P-loop; other site
243365005655	ATP binding site [chemical binding]; other site
243365005656	Q-loop/lid; other site
243365005657	ABC transporter signature motif; other site
243365005658	Walker B; other site
243365005659	D-loop; other site
243365005660	H-loop/switch region; other site
243365005661	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
243365005662	Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007
243365005663	Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861
243365005664	Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845
243365005665	phosphonate C-P lyase system protein PhnG; Region: PhnG_redo; TIGR03293
243365005666	phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325
243365005667	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
243365005668	DNA-binding site [nucleotide binding]; DNA binding site
243365005669	UTRA domain; Region: UTRA; pfam07702
243365005670	putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223
243365005671	phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN; Region: phosphon_PhnN; TIGR02322
243365005672	AAA domain; Region: AAA_18; pfam13238
243365005673	active site
243365005674	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243365005675	dimerization interface [polypeptide binding]; other site
243365005676	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243365005677	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365005678	dimer interface [polypeptide binding]; other site
243365005679	putative CheW interface [polypeptide binding]; other site
243365005680	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243365005681	dimerization interface [polypeptide binding]; other site
243365005682	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365005683	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365005684	metal binding site [ion binding]; metal-binding site
243365005685	active site
243365005686	I-site; other site
243365005687	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243365005688	dimer interface [polypeptide binding]; other site
243365005689	phosphorylation site [posttranslational modification]
243365005690	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365005691	ATP binding site [chemical binding]; other site
243365005692	Mg2+ binding site [ion binding]; other site
243365005693	G-X-G motif; other site
243365005694	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365005695	active site
243365005696	phosphorylation site [posttranslational modification]
243365005697	intermolecular recognition site; other site
243365005698	dimerization interface [polypeptide binding]; other site
243365005699	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
243365005700	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
243365005701	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
243365005702	putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265
243365005703	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243365005704	Walker A/P-loop; other site
243365005705	ATP binding site [chemical binding]; other site
243365005706	Q-loop/lid; other site
243365005707	ABC transporter signature motif; other site
243365005708	Walker B; other site
243365005709	D-loop; other site
243365005710	H-loop/switch region; other site
243365005711	TOBE domain; Region: TOBE_2; pfam08402
243365005712	putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262
243365005713	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
243365005714	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365005715	dimer interface [polypeptide binding]; other site
243365005716	conserved gate region; other site
243365005717	putative PBP binding loops; other site
243365005718	ABC-ATPase subunit interface; other site
243365005719	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
243365005720	Transglycosylase; Region: Transgly; cl17702
243365005721	major facilitator superfamily transporter; Provisional; Region: PRK05122
243365005722	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365005723	D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK; cd07803
243365005724	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
243365005725	N- and C-terminal domain interface [polypeptide binding]; other site
243365005726	active site
243365005727	MgATP binding site [chemical binding]; other site
243365005728	catalytic site [active]
243365005729	metal binding site [ion binding]; metal-binding site
243365005730	xylulose binding site [chemical binding]; other site
243365005731	homodimer interface [polypeptide binding]; other site
243365005732	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
243365005733	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
243365005734	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
243365005735	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
243365005736	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365005737	active site
243365005738	phosphorylation site [posttranslational modification]
243365005739	intermolecular recognition site; other site
243365005740	dimerization interface [polypeptide binding]; other site
243365005741	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
243365005742	DNA binding residues [nucleotide binding]
243365005743	dimerization interface [polypeptide binding]; other site
243365005744	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
243365005745	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243365005746	substrate binding pocket [chemical binding]; other site
243365005747	membrane-bound complex binding site; other site
243365005748	hinge residues; other site
243365005749	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243365005750	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243365005751	dimer interface [polypeptide binding]; other site
243365005752	phosphorylation site [posttranslational modification]
243365005753	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365005754	ATP binding site [chemical binding]; other site
243365005755	Mg2+ binding site [ion binding]; other site
243365005756	G-X-G motif; other site
243365005757	Response regulator receiver domain; Region: Response_reg; pfam00072
243365005758	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365005759	active site
243365005760	phosphorylation site [posttranslational modification]
243365005761	intermolecular recognition site; other site
243365005762	dimerization interface [polypeptide binding]; other site
243365005763	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
243365005764	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343
243365005765	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
243365005766	Autotransporter beta-domain; Region: Autotransporter; pfam03797
243365005767	Cupin domain; Region: Cupin_2; cl17218
243365005768	cyanate hydratase; Validated; Region: PRK02866
243365005769	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
243365005770	oligomer interface [polypeptide binding]; other site
243365005771	active site
243365005772	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
243365005773	active site clefts [active]
243365005774	zinc binding site [ion binding]; other site
243365005775	dimer interface [polypeptide binding]; other site
243365005776	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
243365005777	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365005778	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425
243365005779	dimerization interface [polypeptide binding]; other site
243365005780	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365005781	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365005782	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
243365005783	dimerization interface [polypeptide binding]; other site
243365005784	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
243365005785	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
243365005786	metal binding site [ion binding]; metal-binding site
243365005787	putative dimer interface [polypeptide binding]; other site
243365005788	Protein of unknown function (DUF3100); Region: DUF3100; pfam11299
243365005789	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
243365005790	RHS Repeat; Region: RHS_repeat; pfam05593
243365005791	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
243365005792	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
243365005793	dimer interface [polypeptide binding]; other site
243365005794	ssDNA binding site [nucleotide binding]; other site
243365005795	tetramer (dimer of dimers) interface [polypeptide binding]; other site
243365005796	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
243365005797	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
243365005798	ligand binding site [chemical binding]; other site
243365005799	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365005800	Major Facilitator Superfamily; Region: MFS_1; pfam07690
243365005801	putative substrate translocation pore; other site
243365005802	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
243365005803	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
243365005804	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
243365005805	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
243365005806	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
243365005807	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
243365005808	active site
243365005809	metal binding site [ion binding]; metal-binding site
243365005810	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
243365005811	catalytic residues [active]
243365005812	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
243365005813	aromatic chitin/cellulose binding site residues [chemical binding]; other site
243365005814	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
243365005815	Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325
243365005816	putative sugar binding site [chemical binding]; other site
243365005817	catalytic residues [active]
243365005818	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
243365005819	rRNA binding site [nucleotide binding]; other site
243365005820	predicted 30S ribosome binding site; other site
243365005821	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
243365005822	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
243365005823	DNA-binding site [nucleotide binding]; DNA binding site
243365005824	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
243365005825	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365005826	homodimer interface [polypeptide binding]; other site
243365005827	catalytic residue [active]
243365005828	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
243365005829	Isochorismatase family; Region: Isochorismatase; pfam00857
243365005830	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
243365005831	catalytic triad [active]
243365005832	conserved cis-peptide bond; other site
243365005833	Domain of unknown function (DUF1737); Region: DUF1737; pfam08410
243365005834	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
243365005835	EamA-like transporter family; Region: EamA; pfam00892
243365005836	EamA-like transporter family; Region: EamA; pfam00892
243365005837	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
243365005838	conserved cys residue [active]
243365005839	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
243365005840	LPP20 lipoprotein; Region: LPP20; pfam02169
243365005841	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
243365005842	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
243365005843	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
243365005844	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365005845	dimer interface [polypeptide binding]; other site
243365005846	conserved gate region; other site
243365005847	putative PBP binding loops; other site
243365005848	ABC-ATPase subunit interface; other site
243365005849	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
243365005850	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243365005851	Walker A/P-loop; other site
243365005852	ATP binding site [chemical binding]; other site
243365005853	Q-loop/lid; other site
243365005854	ABC transporter signature motif; other site
243365005855	Walker B; other site
243365005856	D-loop; other site
243365005857	H-loop/switch region; other site
243365005858	TOBE domain; Region: TOBE_2; pfam08402
243365005859	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
243365005860	putative deacylase active site [active]
243365005861	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243365005862	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365005863	dimer interface [polypeptide binding]; other site
243365005864	putative CheW interface [polypeptide binding]; other site
243365005865	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
243365005866	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
243365005867	dimerization interface [polypeptide binding]; other site
243365005868	putative DNA binding site [nucleotide binding]; other site
243365005869	putative Zn2+ binding site [ion binding]; other site
243365005870	AsnC family; Region: AsnC_trans_reg; pfam01037
243365005871	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
243365005872	hydroxyglutarate oxidase; Provisional; Region: PRK11728
243365005873	alanine racemase; Reviewed; Region: dadX; PRK03646
243365005874	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
243365005875	active site
243365005876	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
243365005877	substrate binding site [chemical binding]; other site
243365005878	catalytic residues [active]
243365005879	dimer interface [polypeptide binding]; other site
243365005880	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365005881	PAS fold; Region: PAS_3; pfam08447
243365005882	putative active site [active]
243365005883	heme pocket [chemical binding]; other site
243365005884	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365005885	PAS fold; Region: PAS_3; pfam08447
243365005886	putative active site [active]
243365005887	heme pocket [chemical binding]; other site
243365005888	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365005889	putative CheW interface [polypeptide binding]; other site
243365005890	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
243365005891	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
243365005892	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
243365005893	haemagglutination activity domain; Region: Haemagg_act; pfam05860
243365005894	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
243365005895	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
243365005896	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
243365005897	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
243365005898	Response regulator receiver domain; Region: Response_reg; pfam00072
243365005899	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365005900	active site
243365005901	phosphorylation site [posttranslational modification]
243365005902	intermolecular recognition site; other site
243365005903	dimerization interface [polypeptide binding]; other site
243365005904	Pirin-related protein [General function prediction only]; Region: COG1741
243365005905	Pirin; Region: Pirin; pfam02678
243365005906	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
243365005907	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365005908	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365005909	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
243365005910	dimerization interface [polypeptide binding]; other site
243365005911	Transcriptional regulators [Transcription]; Region: GntR; COG1802
243365005912	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
243365005913	DNA-binding site [nucleotide binding]; DNA binding site
243365005914	FCD domain; Region: FCD; pfam07729
243365005915	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
243365005916	HTH-like domain; Region: HTH_21; pfam13276
243365005917	Integrase core domain; Region: rve; pfam00665
243365005918	Integrase core domain; Region: rve_3; pfam13683
243365005919	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
243365005920	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
243365005921	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
243365005922	homodimer interface [polypeptide binding]; other site
243365005923	NADP binding site [chemical binding]; other site
243365005924	substrate binding site [chemical binding]; other site
243365005925	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
243365005926	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
243365005927	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
243365005928	putative active site [active]
243365005929	putative substrate binding site [chemical binding]; other site
243365005930	putative cosubstrate binding site; other site
243365005931	catalytic site [active]
243365005932	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
243365005933	nudix motif; other site
243365005934	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
243365005935	yecA family protein; Region: ygfB_yecA; TIGR02292
243365005936	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
243365005937	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
243365005938	Nucleoside recognition; Region: Gate; pfam07670
243365005939	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
243365005940	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
243365005941	TRAM domain; Region: TRAM; cl01282
243365005942	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365005943	S-adenosylmethionine binding site [chemical binding]; other site
243365005944	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
243365005945	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
243365005946	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
243365005947	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
243365005948	homodimer interface [polypeptide binding]; other site
243365005949	substrate-cofactor binding pocket; other site
243365005950	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365005951	catalytic residue [active]
243365005952	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
243365005953	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
243365005954	DNA-binding site [nucleotide binding]; DNA binding site
243365005955	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
243365005956	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365005957	homodimer interface [polypeptide binding]; other site
243365005958	catalytic residue [active]
243365005959	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
243365005960	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
243365005961	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
243365005962	HIGH motif; other site
243365005963	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
243365005964	active site
243365005965	KMSKS motif; other site
243365005966	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
243365005967	chromosome condensation membrane protein; Provisional; Region: PRK14196
243365005968	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
243365005969	active site
243365005970	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
243365005971	Uncharacterized conserved protein [Function unknown]; Region: COG4121
243365005972	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
243365005973	Clp amino terminal domain; Region: Clp_N; pfam02861
243365005974	Clp amino terminal domain; Region: Clp_N; pfam02861
243365005975	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243365005976	Walker A motif; other site
243365005977	ATP binding site [chemical binding]; other site
243365005978	Walker B motif; other site
243365005979	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
243365005980	arginine finger; other site
243365005981	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243365005982	Walker A motif; other site
243365005983	ATP binding site [chemical binding]; other site
243365005984	Walker B motif; other site
243365005985	arginine finger; other site
243365005986	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
243365005987	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
243365005988	flagellar assembly protein FliW; Provisional; Region: PRK13284
243365005989	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365005990	Response regulator receiver domain; Region: Response_reg; pfam00072
243365005991	active site
243365005992	phosphorylation site [posttranslational modification]
243365005993	intermolecular recognition site; other site
243365005994	dimerization interface [polypeptide binding]; other site
243365005995	EAL domain; Region: EAL; pfam00563
243365005996	Response regulator receiver domain; Region: Response_reg; pfam00072
243365005997	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365005998	active site
243365005999	phosphorylation site [posttranslational modification]
243365006000	intermolecular recognition site; other site
243365006001	dimerization interface [polypeptide binding]; other site
243365006002	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243365006003	dimer interface [polypeptide binding]; other site
243365006004	phosphorylation site [posttranslational modification]
243365006005	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365006006	ATP binding site [chemical binding]; other site
243365006007	Mg2+ binding site [ion binding]; other site
243365006008	G-X-G motif; other site
243365006009	Response regulator receiver domain; Region: Response_reg; pfam00072
243365006010	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365006011	active site
243365006012	phosphorylation site [posttranslational modification]
243365006013	intermolecular recognition site; other site
243365006014	dimerization interface [polypeptide binding]; other site
243365006015	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
243365006016	putative binding surface; other site
243365006017	active site
243365006018	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
243365006019	dinuclear metal binding motif [ion binding]; other site
243365006020	putative protease; Provisional; Region: PRK15452
243365006021	Peptidase family U32; Region: Peptidase_U32; pfam01136
243365006022	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
243365006023	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
243365006024	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
243365006025	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365006026	dimer interface [polypeptide binding]; other site
243365006027	conserved gate region; other site
243365006028	putative PBP binding loops; other site
243365006029	ABC-ATPase subunit interface; other site
243365006030	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
243365006031	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365006032	dimer interface [polypeptide binding]; other site
243365006033	conserved gate region; other site
243365006034	putative PBP binding loops; other site
243365006035	ABC-ATPase subunit interface; other site
243365006036	Protein of unknown function (DUF3138); Region: DUF3138; pfam11336
243365006037	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
243365006038	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
243365006039	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
243365006040	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
243365006041	active site
243365006042	HIGH motif; other site
243365006043	KMSK motif region; other site
243365006044	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
243365006045	tRNA binding surface [nucleotide binding]; other site
243365006046	anticodon binding site; other site
243365006047	PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; pfam10142
243365006048	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
243365006049	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
243365006050	peptidase domain interface [polypeptide binding]; other site
243365006051	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
243365006052	active site
243365006053	catalytic triad [active]
243365006054	calcium binding site [ion binding]; other site
243365006055	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
243365006056	peptidase domain interface [polypeptide binding]; other site
243365006057	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
243365006058	active site
243365006059	catalytic triad [active]
243365006060	calcium binding site [ion binding]; other site
243365006061	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
243365006062	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
243365006063	N-terminal plug; other site
243365006064	ligand-binding site [chemical binding]; other site
243365006065	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
243365006066	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
243365006067	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
243365006068	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
243365006069	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
243365006070	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
243365006071	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
243365006072	HlyD family secretion protein; Region: HlyD_3; pfam13437
243365006073	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
243365006074	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505
243365006075	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
243365006076	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
243365006077	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
243365006078	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365006079	dimer interface [polypeptide binding]; other site
243365006080	conserved gate region; other site
243365006081	putative PBP binding loops; other site
243365006082	ABC-ATPase subunit interface; other site
243365006083	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
243365006084	microcin C ABC transporter permease; Provisional; Region: PRK15021
243365006085	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365006086	dimer interface [polypeptide binding]; other site
243365006087	conserved gate region; other site
243365006088	putative PBP binding loops; other site
243365006089	ABC-ATPase subunit interface; other site
243365006090	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
243365006091	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
243365006092	Walker A/P-loop; other site
243365006093	ATP binding site [chemical binding]; other site
243365006094	Q-loop/lid; other site
243365006095	ABC transporter signature motif; other site
243365006096	Walker B; other site
243365006097	D-loop; other site
243365006098	H-loop/switch region; other site
243365006099	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
243365006100	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
243365006101	Walker A/P-loop; other site
243365006102	ATP binding site [chemical binding]; other site
243365006103	Q-loop/lid; other site
243365006104	ABC transporter signature motif; other site
243365006105	Walker B; other site
243365006106	D-loop; other site
243365006107	H-loop/switch region; other site
243365006108	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
243365006109	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
243365006110	N-terminal plug; other site
243365006111	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
243365006112	ligand-binding site [chemical binding]; other site
243365006113	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
243365006114	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
243365006115	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
243365006116	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
243365006117	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
243365006118	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
243365006119	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
243365006120	active site
243365006121	Zn binding site [ion binding]; other site
243365006122	Endonuclease I; Region: Endonuclease_1; pfam04231
243365006123	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
243365006124	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
243365006125	trimer interface [polypeptide binding]; other site
243365006126	eyelet of channel; other site
243365006127	Protein of unknown function (DUF3579); Region: DUF3579; pfam12112
243365006128	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
243365006129	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
243365006130	DEAD_2; Region: DEAD_2; pfam06733
243365006131	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
243365006132	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
243365006133	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
243365006134	catalytic residue [active]
243365006135	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
243365006136	ornithine carbamoyltransferase; Provisional; Region: PRK00779
243365006137	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
243365006138	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
243365006139	argininosuccinate synthase; Provisional; Region: PRK13820
243365006140	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
243365006141	ANP binding site [chemical binding]; other site
243365006142	Substrate Binding Site II [chemical binding]; other site
243365006143	Substrate Binding Site I [chemical binding]; other site
243365006144	Protein of unknown function (DUF2788); Region: DUF2788; pfam10981
243365006145	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
243365006146	active site
243365006147	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
243365006148	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
243365006149	dimerization interface [polypeptide binding]; other site
243365006150	domain crossover interface; other site
243365006151	redox-dependent activation switch; other site
243365006152	Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453
243365006153	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
243365006154	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
243365006155	GAF domain; Region: GAF_2; pfam13185
243365006156	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
243365006157	dimerization interface [polypeptide binding]; other site
243365006158	active site
243365006159	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
243365006160	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
243365006161	Multicopper oxidase; Region: Cu-oxidase; pfam00394
243365006162	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
243365006163	Cytochrome c; Region: Cytochrom_C; pfam00034
243365006164	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
243365006165	Uncharacterized conserved protein [Function unknown]; Region: COG1262
243365006166	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
243365006167	Cu(I) binding site [ion binding]; other site
243365006168	conserved hypothetical protein; Region: chp_urease_rgn; TIGR02117
243365006169	Restriction endonuclease; Region: Mrr_cat; pfam04471
243365006170	Predicted membrane protein [Function unknown]; Region: COG2860
243365006171	UPF0126 domain; Region: UPF0126; pfam03458
243365006172	UPF0126 domain; Region: UPF0126; pfam03458
243365006173	Protein of unknown function (DUF3141); Region: DUF3141; pfam11339
243365006174	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365006175	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
243365006176	Coenzyme A binding pocket [chemical binding]; other site
243365006177	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365006178	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
243365006179	dimerization interface [polypeptide binding]; other site
243365006180	azoreductase; Reviewed; Region: PRK00170
243365006181	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
243365006182	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243365006183	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
243365006184	substrate binding pocket [chemical binding]; other site
243365006185	membrane-bound complex binding site; other site
243365006186	hinge residues; other site
243365006187	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243365006188	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243365006189	substrate binding pocket [chemical binding]; other site
243365006190	membrane-bound complex binding site; other site
243365006191	hinge residues; other site
243365006192	gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847
243365006193	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
243365006194	NAD(P) binding site [chemical binding]; other site
243365006195	catalytic residues [active]
243365006196	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
243365006197	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_15; cd07264
243365006198	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
243365006199	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
243365006200	non-specific DNA binding site [nucleotide binding]; other site
243365006201	salt bridge; other site
243365006202	sequence-specific DNA binding site [nucleotide binding]; other site
243365006203	Cupin domain; Region: Cupin_2; pfam07883
243365006204	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
243365006205	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
243365006206	hexamer interface [polypeptide binding]; other site
243365006207	ligand binding site [chemical binding]; other site
243365006208	putative active site [active]
243365006209	NAD(P) binding site [chemical binding]; other site
243365006210	Peptidase C26; Region: Peptidase_C26; pfam07722
243365006211	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
243365006212	catalytic triad [active]
243365006213	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
243365006214	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
243365006215	putative aminotransferase; Validated; Region: PRK07480
243365006216	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
243365006217	inhibitor-cofactor binding pocket; inhibition site
243365006218	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365006219	catalytic residue [active]
243365006220	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
243365006221	flagellar motor protein MotA; Validated; Region: PRK09110
243365006222	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
243365006223	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
243365006224	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
243365006225	ligand binding site [chemical binding]; other site
243365006226	Methyltransferase domain; Region: Methyltransf_18; pfam12847
243365006227	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
243365006228	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
243365006229	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
243365006230	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
243365006231	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
243365006232	active site
243365006233	NTP binding site [chemical binding]; other site
243365006234	metal binding triad [ion binding]; metal-binding site
243365006235	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
243365006236	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243365006237	Zn2+ binding site [ion binding]; other site
243365006238	Mg2+ binding site [ion binding]; other site
243365006239	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
243365006240	NADH(P)-binding; Region: NAD_binding_10; pfam13460
243365006241	putative NAD(P) binding site [chemical binding]; other site
243365006242	active site
243365006243	lytic murein transglycosylase; Provisional; Region: PRK11619
243365006244	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
243365006245	N-acetyl-D-glucosamine binding site [chemical binding]; other site
243365006246	catalytic residue [active]
243365006247	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
243365006248	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
243365006249	putative metal binding site [ion binding]; other site
243365006250	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
243365006251	catalytic triad [active]
243365006252	dimer interface [polypeptide binding]; other site
243365006253	Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029
243365006254	GSH binding site [chemical binding]; other site
243365006255	catalytic residues [active]
243365006256	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
243365006257	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
243365006258	Shigella flexneri OspC protein; Region: Shigella_OspC; pfam06128
243365006259	acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814
243365006260	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
243365006261	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
243365006262	Nucleoside recognition; Region: Gate; pfam07670
243365006263	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
243365006264	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
243365006265	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
243365006266	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
243365006267	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
243365006268	metal-binding site [ion binding]
243365006269	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
243365006270	Soluble P-type ATPase [General function prediction only]; Region: COG4087
243365006271	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
243365006272	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
243365006273	NAD(P) binding site [chemical binding]; other site
243365006274	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
243365006275	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
243365006276	dimerization interface [polypeptide binding]; other site
243365006277	ATP binding site [chemical binding]; other site
243365006278	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
243365006279	dimerization interface [polypeptide binding]; other site
243365006280	ATP binding site [chemical binding]; other site
243365006281	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
243365006282	putative active site [active]
243365006283	catalytic triad [active]
243365006284	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
243365006285	Nitrogen regulatory protein P-II; Region: P-II; smart00938
243365006286	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
243365006287	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
243365006288	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
243365006289	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
243365006290	dihydrodipicolinate synthase; Region: dapA; TIGR00674
243365006291	dimer interface [polypeptide binding]; other site
243365006292	active site
243365006293	catalytic residue [active]
243365006294	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
243365006295	EamA-like transporter family; Region: EamA; pfam00892
243365006296	NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285
243365006297	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
243365006298	tetramer interface [polypeptide binding]; other site
243365006299	catalytic Zn binding site [ion binding]; other site
243365006300	NADP binding site [chemical binding]; other site
243365006301	Cupin domain; Region: Cupin_2; pfam07883
243365006302	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
243365006303	2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333
243365006304	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
243365006305	substrate binding site [chemical binding]; other site
243365006306	ligand binding site [chemical binding]; other site
243365006307	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
243365006308	substrate binding site [chemical binding]; other site
243365006309	Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475
243365006310	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
243365006311	Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117
243365006312	dimer interface [polypeptide binding]; other site
243365006313	active site
243365006314	citrylCoA binding site [chemical binding]; other site
243365006315	oxalacetate/citrate binding site [chemical binding]; other site
243365006316	coenzyme A binding site [chemical binding]; other site
243365006317	catalytic triad [active]
243365006318	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
243365006319	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
243365006320	tetramer interface [polypeptide binding]; other site
243365006321	active site
243365006322	Mg2+/Mn2+ binding site [ion binding]; other site
243365006323	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
243365006324	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
243365006325	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
243365006326	DNA binding residues [nucleotide binding]
243365006327	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
243365006328	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
243365006329	anti-sigma E factor; Provisional; Region: rseB; PRK09455
243365006330	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
243365006331	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
243365006332	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
243365006333	protein binding site [polypeptide binding]; other site
243365006334	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
243365006335	protein binding site [polypeptide binding]; other site
243365006336	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
243365006337	GTP-binding protein LepA; Provisional; Region: PRK05433
243365006338	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
243365006339	G1 box; other site
243365006340	putative GEF interaction site [polypeptide binding]; other site
243365006341	GTP/Mg2+ binding site [chemical binding]; other site
243365006342	Switch I region; other site
243365006343	G2 box; other site
243365006344	G3 box; other site
243365006345	Switch II region; other site
243365006346	G4 box; other site
243365006347	G5 box; other site
243365006348	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
243365006349	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
243365006350	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
243365006351	signal peptidase I; Provisional; Region: PRK10861
243365006352	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
243365006353	Catalytic site [active]
243365006354	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
243365006355	ribonuclease III; Reviewed; Region: rnc; PRK00102
243365006356	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
243365006357	dimerization interface [polypeptide binding]; other site
243365006358	active site
243365006359	metal binding site [ion binding]; metal-binding site
243365006360	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
243365006361	dsRNA binding site [nucleotide binding]; other site
243365006362	GTPase Era; Reviewed; Region: era; PRK00089
243365006363	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
243365006364	G1 box; other site
243365006365	GTP/Mg2+ binding site [chemical binding]; other site
243365006366	Switch I region; other site
243365006367	G2 box; other site
243365006368	Switch II region; other site
243365006369	G3 box; other site
243365006370	G4 box; other site
243365006371	G5 box; other site
243365006372	KH domain; Region: KH_2; pfam07650
243365006373	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
243365006374	Recombination protein O N terminal; Region: RecO_N; pfam11967
243365006375	Recombination protein O C terminal; Region: RecO_C; pfam02565
243365006376	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
243365006377	active site
243365006378	hydrophilic channel; other site
243365006379	dimerization interface [polypeptide binding]; other site
243365006380	catalytic residues [active]
243365006381	active site lid [active]
243365006382	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
243365006383	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
243365006384	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
243365006385	beta-hexosaminidase; Provisional; Region: PRK05337
243365006386	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
243365006387	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
243365006388	putative MPT binding site; other site
243365006389	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365006390	Coenzyme A binding pocket [chemical binding]; other site
243365006391	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
243365006392	ribosome small subunit-dependent GTPase A; Region: TIGR00157
243365006393	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
243365006394	GTPase/Zn-binding domain interface [polypeptide binding]; other site
243365006395	GTP/Mg2+ binding site [chemical binding]; other site
243365006396	G4 box; other site
243365006397	G5 box; other site
243365006398	G1 box; other site
243365006399	Switch I region; other site
243365006400	G2 box; other site
243365006401	G3 box; other site
243365006402	Switch II region; other site
243365006403	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
243365006404	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
243365006405	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
243365006406	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
243365006407	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
243365006408	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
243365006409	substrate binding site [chemical binding]; other site
243365006410	oxyanion hole (OAH) forming residues; other site
243365006411	trimer interface [polypeptide binding]; other site
243365006412	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
243365006413	enoyl-CoA hydratase; Provisional; Region: PRK09076
243365006414	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
243365006415	substrate binding site [chemical binding]; other site
243365006416	oxyanion hole (OAH) forming residues; other site
243365006417	trimer interface [polypeptide binding]; other site
243365006418	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
243365006419	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
243365006420	substrate binding pocket [chemical binding]; other site
243365006421	FAD binding site [chemical binding]; other site
243365006422	catalytic base [active]
243365006423	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
243365006424	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
243365006425	tetrameric interface [polypeptide binding]; other site
243365006426	NAD binding site [chemical binding]; other site
243365006427	catalytic residues [active]
243365006428	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
243365006429	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
243365006430	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
243365006431	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
243365006432	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
243365006433	DNA binding residues [nucleotide binding]
243365006434	putative dimer interface [polypeptide binding]; other site
243365006435	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
243365006436	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
243365006437	dimer interface [polypeptide binding]; other site
243365006438	active site
243365006439	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
243365006440	ATP binding site [chemical binding]; other site
243365006441	putative Mg++ binding site [ion binding]; other site
243365006442	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243365006443	nucleotide binding region [chemical binding]; other site
243365006444	ATP-binding site [chemical binding]; other site
243365006445	Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513
243365006446	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243365006447	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
243365006448	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
243365006449	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
243365006450	putative active site [active]
243365006451	Zinc-finger domain; Region: zf-CHCC; cl01821
243365006452	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
243365006453	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
243365006454	homodimer interface [polypeptide binding]; other site
243365006455	substrate-cofactor binding pocket; other site
243365006456	catalytic residue [active]
243365006457	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
243365006458	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
243365006459	metal binding triad; other site
243365006460	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
243365006461	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
243365006462	metal binding triad; other site
243365006463	TIGR02099 family protein; Region: TIGR02099
243365006464	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
243365006465	nitrilase; Region: PLN02798
243365006466	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
243365006467	putative active site [active]
243365006468	catalytic triad [active]
243365006469	dimer interface [polypeptide binding]; other site
243365006470	protease TldD; Provisional; Region: tldD; PRK10735
243365006471	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
243365006472	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
243365006473	conserved cys residue [active]
243365006474	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
243365006475	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
243365006476	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
243365006477	metal binding site [ion binding]; metal-binding site
243365006478	putative dimer interface [polypeptide binding]; other site
243365006479	Protein of unknown function (DUF1302); Region: DUF1302; pfam06980
243365006480	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
243365006481	ligand-binding site [chemical binding]; other site
243365006482	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
243365006483	Predicted transcriptional regulators [Transcription]; Region: COG1510
243365006484	MarR family; Region: MarR_2; pfam12802
243365006485	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
243365006486	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
243365006487	putative NAD(P) binding site [chemical binding]; other site
243365006488	active site
243365006489	DoxX-like family; Region: DoxX_3; pfam13781
243365006490	Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027
243365006491	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
243365006492	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
243365006493	Baseplate J-like protein; Region: Baseplate_J; cl01294
243365006494	Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812
243365006495	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
243365006496	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
243365006497	Phage Tail Protein X; Region: Phage_tail_X; pfam05489
243365006498	Phage P2 GpU; Region: Phage_P2_GpU; pfam06995
243365006499	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
243365006500	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
243365006501	PAAR motif; Region: PAAR_motif; pfam05488
243365006502	Phage tail tube protein FII; Region: Phage_tube; cl01390
243365006503	major tail sheath protein; Provisional; Region: FI; PHA02560
243365006504	Gp37 protein; Region: Gp37; pfam09646
243365006505	Protein of unknown function (DUF1320); Region: DUF1320; pfam07030
243365006506	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
243365006507	Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123
243365006508	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
243365006509	Phage Mu protein F like protein; Region: Phage_Mu_F; pfam04233
243365006510	Protein of unknown function (DUF935); Region: DUF935; pfam06074
243365006511	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
243365006512	Protein of unknown function (DUF3486); Region: DUF3486; pfam11985
243365006513	phage/conjugal plasmid C-4 type zinc finger protein, TraR family; Region: C4_traR_proteo; TIGR02419
243365006514	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
243365006515	transcriptional repressor DicA; Reviewed; Region: PRK09706
243365006516	phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111
243365006517	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
243365006518	putative Zn2+ binding site [ion binding]; other site
243365006519	putative DNA binding site [nucleotide binding]; other site
243365006520	dimerization interface [polypeptide binding]; other site
243365006521	Integrase core domain; Region: rve; pfam00665
243365006522	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
243365006523	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243365006524	Walker A/P-loop; other site
243365006525	ATP binding site [chemical binding]; other site
243365006526	Protein of unknown function (DUF3164); Region: DUF3164; pfam11363
243365006527	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
243365006528	IHF dimer interface [polypeptide binding]; other site
243365006529	IHF - DNA interface [nucleotide binding]; other site
243365006530	Protein of unknown function (DUF1018); Region: DUF1018; pfam06252
243365006531	Mor transcription activator family; Region: Mor; pfam08765
243365006532	Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027
243365006533	2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390
243365006534	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
243365006535	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
243365006536	substrate binding site [chemical binding]; other site
243365006537	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
243365006538	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
243365006539	substrate binding site [chemical binding]; other site
243365006540	ligand binding site [chemical binding]; other site
243365006541	transcriptional activator TtdR; Provisional; Region: PRK09801
243365006542	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365006543	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
243365006544	putative effector binding pocket; other site
243365006545	putative dimerization interface [polypeptide binding]; other site
243365006546	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
243365006547	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365006548	S-adenosylmethionine binding site [chemical binding]; other site
243365006549	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
243365006550	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
243365006551	active site
243365006552	substrate binding site [chemical binding]; other site
243365006553	metal binding site [ion binding]; metal-binding site
243365006554	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
243365006555	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
243365006556	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
243365006557	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
243365006558	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
243365006559	glutamine binding [chemical binding]; other site
243365006560	catalytic triad [active]
243365006561	Predicted transcriptional regulators [Transcription]; Region: COG1733
243365006562	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
243365006563	short chain dehydrogenase; Provisional; Region: PRK06500
243365006564	classical (c) SDRs; Region: SDR_c; cd05233
243365006565	NAD(P) binding site [chemical binding]; other site
243365006566	active site
243365006567	anthranilate synthase component I; Provisional; Region: PRK13565
243365006568	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
243365006569	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
243365006570	phosphoglycolate phosphatase; Provisional; Region: PRK13222
243365006571	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243365006572	motif II; other site
243365006573	short chain dehydrogenase; Provisional; Region: PRK07023
243365006574	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243365006575	NAD(P) binding site [chemical binding]; other site
243365006576	active site
243365006577	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
243365006578	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
243365006579	substrate binding site [chemical binding]; other site
243365006580	hexamer interface [polypeptide binding]; other site
243365006581	metal binding site [ion binding]; metal-binding site
243365006582	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
243365006583	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
243365006584	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
243365006585	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
243365006586	Walker A/P-loop; other site
243365006587	ATP binding site [chemical binding]; other site
243365006588	Q-loop/lid; other site
243365006589	ABC transporter signature motif; other site
243365006590	Walker B; other site
243365006591	D-loop; other site
243365006592	H-loop/switch region; other site
243365006593	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
243365006594	PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424
243365006595	active site
243365006596	metal binding site [ion binding]; metal-binding site
243365006597	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
243365006598	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243365006599	Zn2+ binding site [ion binding]; other site
243365006600	Mg2+ binding site [ion binding]; other site
243365006601	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
243365006602	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
243365006603	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
243365006604	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
243365006605	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
243365006606	RNA binding surface [nucleotide binding]; other site
243365006607	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
243365006608	active site
243365006609	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
243365006610	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
243365006611	binding surface
243365006612	TPR motif; other site
243365006613	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
243365006614	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
243365006615	FMN binding site [chemical binding]; other site
243365006616	substrate binding site [chemical binding]; other site
243365006617	putative catalytic residue [active]
243365006618	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
243365006619	rRNA interaction site [nucleotide binding]; other site
243365006620	S8 interaction site; other site
243365006621	putative laminin-1 binding site; other site
243365006622	elongation factor Ts; Provisional; Region: tsf; PRK09377
243365006623	UBA/TS-N domain; Region: UBA; pfam00627
243365006624	Elongation factor TS; Region: EF_TS; pfam00889
243365006625	Elongation factor TS; Region: EF_TS; pfam00889
243365006626	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
243365006627	putative nucleotide binding site [chemical binding]; other site
243365006628	uridine monophosphate binding site [chemical binding]; other site
243365006629	homohexameric interface [polypeptide binding]; other site
243365006630	ribosome recycling factor; Reviewed; Region: frr; PRK00083
243365006631	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
243365006632	hinge region; other site
243365006633	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
243365006634	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
243365006635	catalytic residue [active]
243365006636	putative FPP diphosphate  binding site; other site
243365006637	putative FPP binding hydrophobic cleft; other site
243365006638	dimer interface [polypeptide binding]; other site
243365006639	putative IPP diphosphate binding site; other site
243365006640	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
243365006641	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
243365006642	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
243365006643	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
243365006644	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
243365006645	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
243365006646	zinc metallopeptidase RseP; Provisional; Region: PRK10779
243365006647	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
243365006648	active site
243365006649	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
243365006650	protein binding site [polypeptide binding]; other site
243365006651	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
243365006652	protein binding site [polypeptide binding]; other site
243365006653	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
243365006654	putative substrate binding region [chemical binding]; other site
243365006655	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
243365006656	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
243365006657	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
243365006658	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
243365006659	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
243365006660	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
243365006661	Surface antigen; Region: Bac_surface_Ag; pfam01103
243365006662	periplasmic chaperone; Provisional; Region: PRK10780
243365006663	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
243365006664	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
243365006665	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
243365006666	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
243365006667	trimer interface [polypeptide binding]; other site
243365006668	active site
243365006669	UDP-GlcNAc binding site [chemical binding]; other site
243365006670	lipid binding site [chemical binding]; lipid-binding site
243365006671	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
243365006672	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
243365006673	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
243365006674	active site
243365006675	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
243365006676	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
243365006677	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
243365006678	RNA/DNA hybrid binding site [nucleotide binding]; other site
243365006679	active site
243365006680	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
243365006681	putative active site [active]
243365006682	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243365006683	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243365006684	dimer interface [polypeptide binding]; other site
243365006685	phosphorylation site [posttranslational modification]
243365006686	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365006687	ATP binding site [chemical binding]; other site
243365006688	Mg2+ binding site [ion binding]; other site
243365006689	G-X-G motif; other site
243365006690	Response regulator receiver domain; Region: Response_reg; pfam00072
243365006691	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365006692	active site
243365006693	phosphorylation site [posttranslational modification]
243365006694	intermolecular recognition site; other site
243365006695	dimerization interface [polypeptide binding]; other site
243365006696	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
243365006697	putative binding surface; other site
243365006698	active site
243365006699	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
243365006700	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
243365006701	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365006702	active site
243365006703	phosphorylation site [posttranslational modification]
243365006704	intermolecular recognition site; other site
243365006705	dimerization interface [polypeptide binding]; other site
243365006706	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243365006707	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
243365006708	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
243365006709	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
243365006710	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
243365006711	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
243365006712	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
243365006713	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
243365006714	metallophosphoesterase, PPA1498 family; Region: P_acnes_RR; cl17623
243365006715	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
243365006716	GAF domain; Region: GAF; pfam01590
243365006717	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
243365006718	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
243365006719	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
243365006720	HTH-like domain; Region: HTH_21; pfam13276
243365006721	Integrase core domain; Region: rve; pfam00665
243365006722	Integrase core domain; Region: rve_3; pfam13683
243365006723	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
243365006724	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
243365006725	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
243365006726	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365006727	active site
243365006728	phosphorylation site [posttranslational modification]
243365006729	intermolecular recognition site; other site
243365006730	dimerization interface [polypeptide binding]; other site
243365006731	ANTAR domain; Region: ANTAR; pfam03861
243365006732	NMT1-like family; Region: NMT1_2; pfam13379
243365006733	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
243365006734	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
243365006735	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365006736	putative substrate translocation pore; other site
243365006737	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
243365006738	[4Fe-4S] binding site [ion binding]; other site
243365006739	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
243365006740	molybdopterin cofactor binding site; other site
243365006741	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
243365006742	molybdopterin cofactor binding site; other site
243365006743	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
243365006744	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
243365006745	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
243365006746	N-terminal plug; other site
243365006747	ligand-binding site [chemical binding]; other site
243365006748	enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439
243365006749	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
243365006750	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
243365006751	MbtH-like protein; Region: MbtH; pfam03621
243365006752	Condensation domain; Region: Condensation; pfam00668
243365006753	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
243365006754	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
243365006755	acyl-activating enzyme (AAE) consensus motif; other site
243365006756	AMP binding site [chemical binding]; other site
243365006757	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
243365006758	Condensation domain; Region: Condensation; pfam00668
243365006759	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
243365006760	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
243365006761	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
243365006762	acyl-activating enzyme (AAE) consensus motif; other site
243365006763	AMP binding site [chemical binding]; other site
243365006764	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
243365006765	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
243365006766	Walker A/P-loop; other site
243365006767	ATP binding site [chemical binding]; other site
243365006768	Q-loop/lid; other site
243365006769	ABC transporter signature motif; other site
243365006770	Walker B; other site
243365006771	D-loop; other site
243365006772	H-loop/switch region; other site
243365006773	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
243365006774	ABC-ATPase subunit  interface; other site
243365006775	dimer interface [polypeptide binding]; other site
243365006776	putative PBP binding regions; other site
243365006777	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
243365006778	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
243365006779	ABC-ATPase subunit  interface; other site
243365006780	dimer interface [polypeptide binding]; other site
243365006781	putative PBP binding regions; other site
243365006782	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365006783	H+ Antiporter protein; Region: 2A0121; TIGR00900
243365006784	putative substrate translocation pore; other site
243365006785	iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957
243365006786	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
243365006787	intersubunit interface [polypeptide binding]; other site
243365006788	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
243365006789	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
243365006790	HlyD family secretion protein; Region: HlyD_3; pfam13437
243365006791	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
243365006792	Outer membrane efflux protein; Region: OEP; pfam02321
243365006793	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
243365006794	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
243365006795	dimer interface [polypeptide binding]; other site
243365006796	putative metal binding site [ion binding]; other site
243365006797	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
243365006798	dimer interface [polypeptide binding]; other site
243365006799	FMN binding site [chemical binding]; other site
243365006800	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
243365006801	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
243365006802	FMN binding site [chemical binding]; other site
243365006803	active site
243365006804	substrate binding site [chemical binding]; other site
243365006805	catalytic residue [active]
243365006806	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
243365006807	DNA binding residues [nucleotide binding]
243365006808	dimerization interface [polypeptide binding]; other site
243365006809	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
243365006810	active site
243365006811	intersubunit interactions; other site
243365006812	catalytic residue [active]
243365006813	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
243365006814	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365006815	putative substrate translocation pore; other site
243365006816	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
243365006817	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
243365006818	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
243365006819	N-terminal plug; other site
243365006820	ligand-binding site [chemical binding]; other site
243365006821	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14464
243365006822	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
243365006823	FeS/SAM binding site; other site
243365006824	maltose O-acetyltransferase; Provisional; Region: PRK10092
243365006825	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
243365006826	active site
243365006827	substrate binding site [chemical binding]; other site
243365006828	trimer interface [polypeptide binding]; other site
243365006829	CoA binding site [chemical binding]; other site
243365006830	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
243365006831	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
243365006832	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
243365006833	catalytic residue [active]
243365006834	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
243365006835	TPP-binding site [chemical binding]; other site
243365006836	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
243365006837	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
243365006838	classical (c) SDRs; Region: SDR_c; cd05233
243365006839	NAD(P) binding site [chemical binding]; other site
243365006840	active site
243365006841	Protein of unknown function (DUF1349); Region: DUF1349; cl01397
243365006842	Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116
243365006843	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243365006844	O-methyltransferase; Region: Methyltransf_2; pfam00891
243365006845	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
243365006846	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
243365006847	active site
243365006848	catalytic triad [active]
243365006849	oxyanion hole [active]
243365006850	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
243365006851	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
243365006852	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
243365006853	active site
243365006854	substrate binding site [chemical binding]; other site
243365006855	ATP binding site [chemical binding]; other site
243365006856	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
243365006857	AIPR protein; Region: AIPR; pfam10592
243365006858	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
243365006859	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
243365006860	dimer interface [polypeptide binding]; other site
243365006861	putative radical transfer pathway; other site
243365006862	diiron center [ion binding]; other site
243365006863	tyrosyl radical; other site
243365006864	SnoaL-like domain; Region: SnoaL_3; pfam13474
243365006865	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207
243365006866	ATP cone domain; Region: ATP-cone; pfam03477
243365006867	ATP cone domain; Region: ATP-cone; pfam03477
243365006868	Class I ribonucleotide reductase; Region: RNR_I; cd01679
243365006869	active site
243365006870	dimer interface [polypeptide binding]; other site
243365006871	catalytic residues [active]
243365006872	effector binding site; other site
243365006873	R2 peptide binding site; other site
243365006874	Protein of unknown function (DUF3443); Region: DUF3443; pfam11925
243365006875	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
243365006876	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
243365006877	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
243365006878	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
243365006879	Walker A/P-loop; other site
243365006880	ATP binding site [chemical binding]; other site
243365006881	Q-loop/lid; other site
243365006882	ABC transporter signature motif; other site
243365006883	Walker B; other site
243365006884	D-loop; other site
243365006885	H-loop/switch region; other site
243365006886	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
243365006887	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
243365006888	Salmonella outer protein D; Region: SopD; cl14701
243365006889	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
243365006890	activation loop (A-loop); other site
243365006891	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
243365006892	putative catalytic site [active]
243365006893	putative metal binding site [ion binding]; other site
243365006894	putative phosphate binding site [ion binding]; other site
243365006895	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
243365006896	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
243365006897	Walker A/P-loop; other site
243365006898	ATP binding site [chemical binding]; other site
243365006899	Q-loop/lid; other site
243365006900	ABC transporter signature motif; other site
243365006901	Walker B; other site
243365006902	D-loop; other site
243365006903	H-loop/switch region; other site
243365006904	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365006905	dimer interface [polypeptide binding]; other site
243365006906	conserved gate region; other site
243365006907	ABC-ATPase subunit interface; other site
243365006908	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
243365006909	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
243365006910	DNA gyrase subunit A; Validated; Region: PRK05560
243365006911	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
243365006912	CAP-like domain; other site
243365006913	active site
243365006914	primary dimer interface [polypeptide binding]; other site
243365006915	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
243365006916	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
243365006917	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
243365006918	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
243365006919	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
243365006920	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
243365006921	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
243365006922	CoenzymeA binding site [chemical binding]; other site
243365006923	subunit interaction site [polypeptide binding]; other site
243365006924	PHB binding site; other site
243365006925	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
243365006926	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
243365006927	CoenzymeA binding site [chemical binding]; other site
243365006928	subunit interaction site [polypeptide binding]; other site
243365006929	PHB binding site; other site
243365006930	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
243365006931	homodimer interface [polypeptide binding]; other site
243365006932	substrate-cofactor binding pocket; other site
243365006933	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365006934	catalytic residue [active]
243365006935	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
243365006936	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
243365006937	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
243365006938	dimer interface [polypeptide binding]; other site
243365006939	catalytic triad [active]
243365006940	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
243365006941	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
243365006942	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
243365006943	Active Sites [active]
243365006944	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
243365006945	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
243365006946	CysD dimerization site [polypeptide binding]; other site
243365006947	G1 box; other site
243365006948	putative GEF interaction site [polypeptide binding]; other site
243365006949	GTP/Mg2+ binding site [chemical binding]; other site
243365006950	Switch I region; other site
243365006951	G2 box; other site
243365006952	G3 box; other site
243365006953	Switch II region; other site
243365006954	G4 box; other site
243365006955	G5 box; other site
243365006956	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
243365006957	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
243365006958	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365006959	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365006960	metal binding site [ion binding]; metal-binding site
243365006961	active site
243365006962	I-site; other site
243365006963	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243365006964	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
243365006965	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
243365006966	active site
243365006967	P-loop; other site
243365006968	phosphorylation site [posttranslational modification]
243365006969	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
243365006970	dimerization domain swap beta strand [polypeptide binding]; other site
243365006971	regulatory protein interface [polypeptide binding]; other site
243365006972	active site
243365006973	regulatory phosphorylation site [posttranslational modification]; other site
243365006974	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
243365006975	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
243365006976	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
243365006977	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
243365006978	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
243365006979	active site
243365006980	phosphorylation site [posttranslational modification]
243365006981	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
243365006982	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
243365006983	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
243365006984	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
243365006985	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
243365006986	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
243365006987	Transposase, Mutator family; Region: Transposase_mut; pfam00872
243365006988	MULE transposase domain; Region: MULE; pfam10551
243365006989	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
243365006990	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
243365006991	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
243365006992	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
243365006993	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
243365006994	Walker A/P-loop; other site
243365006995	ATP binding site [chemical binding]; other site
243365006996	Q-loop/lid; other site
243365006997	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
243365006998	ABC transporter signature motif; other site
243365006999	Walker B; other site
243365007000	D-loop; other site
243365007001	H-loop/switch region; other site
243365007002	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04539
243365007003	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
243365007004	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
243365007005	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365007006	active site
243365007007	phosphorylation site [posttranslational modification]
243365007008	intermolecular recognition site; other site
243365007009	dimerization interface [polypeptide binding]; other site
243365007010	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
243365007011	DNA binding residues [nucleotide binding]
243365007012	dimerization interface [polypeptide binding]; other site
243365007013	PAS fold; Region: PAS_4; pfam08448
243365007014	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243365007015	dimer interface [polypeptide binding]; other site
243365007016	phosphorylation site [posttranslational modification]
243365007017	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365007018	ATP binding site [chemical binding]; other site
243365007019	Mg2+ binding site [ion binding]; other site
243365007020	G-X-G motif; other site
243365007021	methionine sulfoxide reductase A; Provisional; Region: PRK14054
243365007022	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
243365007023	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
243365007024	putative active site [active]
243365007025	Zn binding site [ion binding]; other site
243365007026	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
243365007027	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
243365007028	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365007029	Coenzyme A binding pocket [chemical binding]; other site
243365007030	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
243365007031	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
243365007032	FMN binding site [chemical binding]; other site
243365007033	active site
243365007034	catalytic residues [active]
243365007035	substrate binding site [chemical binding]; other site
243365007036	Mechanosensitive ion channel; Region: MS_channel; pfam00924
243365007037	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
243365007038	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
243365007039	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
243365007040	ligand binding site [chemical binding]; other site
243365007041	flexible hinge region; other site
243365007042	Predicted transcriptional regulator [Transcription]; Region: COG2932
243365007043	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
243365007044	Catalytic site [active]
243365007045	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
243365007046	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
243365007047	active site
243365007048	HTH domain; Region: HTH_11; pfam08279
243365007049	Predicted transcriptional regulator [Transcription]; Region: COG2378
243365007050	WYL domain; Region: WYL; pfam13280
243365007051	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140
243365007052	conserved cys residue [active]
243365007053	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365007054	Coenzyme A binding pocket [chemical binding]; other site
243365007055	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
243365007056	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
243365007057	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365007058	Coenzyme A binding pocket [chemical binding]; other site
243365007059	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
243365007060	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261
243365007061	putative dimer interface [polypeptide binding]; other site
243365007062	thymidine kinase; Provisional; Region: PRK04296
243365007063	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
243365007064	ATP binding site [chemical binding]; other site
243365007065	Walker A motif; other site
243365007066	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
243365007067	FMN binding site [chemical binding]; other site
243365007068	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
243365007069	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
243365007070	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
243365007071	probable active site [active]
243365007072	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
243365007073	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
243365007074	ligand binding site [chemical binding]; other site
243365007075	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
243365007076	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
243365007077	Walker A/P-loop; other site
243365007078	ATP binding site [chemical binding]; other site
243365007079	Q-loop/lid; other site
243365007080	ABC transporter signature motif; other site
243365007081	Walker B; other site
243365007082	D-loop; other site
243365007083	H-loop/switch region; other site
243365007084	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
243365007085	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
243365007086	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
243365007087	TM-ABC transporter signature motif; other site
243365007088	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
243365007089	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
243365007090	TM-ABC transporter signature motif; other site
243365007091	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
243365007092	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
243365007093	dimer interface [polypeptide binding]; other site
243365007094	putative functional site; other site
243365007095	putative MPT binding site; other site
243365007096	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
243365007097	Domain of unknown function DUF20; Region: UPF0118; pfam01594
243365007098	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
243365007099	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
243365007100	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
243365007101	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
243365007102	DsbD alpha interface [polypeptide binding]; other site
243365007103	catalytic residues [active]
243365007104	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
243365007105	PGAP1-like protein; Region: PGAP1; pfam07819
243365007106	Chorismate mutase type II; Region: CM_2; cl00693
243365007107	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
243365007108	Prephenate dehydratase; Region: PDT; pfam00800
243365007109	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
243365007110	putative L-Phe binding site [chemical binding]; other site
243365007111	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
243365007112	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
243365007113	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
243365007114	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
243365007115	ligand binding site [chemical binding]; other site
243365007116	active site
243365007117	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
243365007118	FMN binding site [chemical binding]; other site
243365007119	substrate binding site [chemical binding]; other site
243365007120	putative catalytic residue [active]
243365007121	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
243365007122	active site
243365007123	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
243365007124	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
243365007125	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
243365007126	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
243365007127	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
243365007128	NAD(P) binding site [chemical binding]; other site
243365007129	homotetramer interface [polypeptide binding]; other site
243365007130	homodimer interface [polypeptide binding]; other site
243365007131	active site
243365007132	GTPase RsgA; Reviewed; Region: PRK00098
243365007133	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
243365007134	RNA binding site [nucleotide binding]; other site
243365007135	homodimer interface [polypeptide binding]; other site
243365007136	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
243365007137	GTPase/Zn-binding domain interface [polypeptide binding]; other site
243365007138	GTP/Mg2+ binding site [chemical binding]; other site
243365007139	G4 box; other site
243365007140	G5 box; other site
243365007141	G1 box; other site
243365007142	Switch I region; other site
243365007143	G2 box; other site
243365007144	G3 box; other site
243365007145	Switch II region; other site
243365007146	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
243365007147	aromatic arch; other site
243365007148	DCoH dimer interaction site [polypeptide binding]; other site
243365007149	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
243365007150	DCoH tetramer interaction site [polypeptide binding]; other site
243365007151	substrate binding site [chemical binding]; other site
243365007152	Peptidase family M48; Region: Peptidase_M48; pfam01435
243365007153	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
243365007154	catalytic site [active]
243365007155	putative active site [active]
243365007156	putative substrate binding site [chemical binding]; other site
243365007157	dimer interface [polypeptide binding]; other site
243365007158	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
243365007159	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
243365007160	active site
243365007161	dimer interface [polypeptide binding]; other site
243365007162	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
243365007163	dimer interface [polypeptide binding]; other site
243365007164	active site
243365007165	Competence-damaged protein; Region: CinA; cl00666
243365007166	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
243365007167	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
243365007168	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
243365007169	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
243365007170	active site
243365007171	DNA binding site [nucleotide binding]
243365007172	Int/Topo IB signature motif; other site
243365007173	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
243365007174	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243365007175	Walker A motif; other site
243365007176	ATP binding site [chemical binding]; other site
243365007177	Walker B motif; other site
243365007178	arginine finger; other site
243365007179	tellurium resistance terB-like protein; Region: terB_like; cl11965
243365007180	metal binding site [ion binding]; metal-binding site
243365007181	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
243365007182	active site
243365007183	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
243365007184	Ligand Binding Site [chemical binding]; other site
243365007185	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
243365007186	non-specific DNA binding site [nucleotide binding]; other site
243365007187	salt bridge; other site
243365007188	sequence-specific DNA binding site [nucleotide binding]; other site
243365007189	acetylornithine deacetylase; Provisional; Region: PRK07522
243365007190	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
243365007191	metal binding site [ion binding]; metal-binding site
243365007192	putative dimer interface [polypeptide binding]; other site
243365007193	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
243365007194	Na2 binding site [ion binding]; other site
243365007195	putative substrate binding site 1 [chemical binding]; other site
243365007196	Na binding site 1 [ion binding]; other site
243365007197	putative substrate binding site 2 [chemical binding]; other site
243365007198	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
243365007199	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
243365007200	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365007201	homodimer interface [polypeptide binding]; other site
243365007202	catalytic residue [active]
243365007203	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243365007204	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
243365007205	Bacterial transcriptional repressor; Region: TetR; pfam13972
243365007206	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
243365007207	Mechanosensitive ion channel; Region: MS_channel; pfam00924
243365007208	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
243365007209	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
243365007210	G1 box; other site
243365007211	putative GEF interaction site [polypeptide binding]; other site
243365007212	GTP/Mg2+ binding site [chemical binding]; other site
243365007213	Switch I region; other site
243365007214	G2 box; other site
243365007215	G3 box; other site
243365007216	Switch II region; other site
243365007217	G4 box; other site
243365007218	G5 box; other site
243365007219	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
243365007220	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
243365007221	Lumazine binding domain; Region: Lum_binding; pfam00677
243365007222	Lumazine binding domain; Region: Lum_binding; pfam00677
243365007223	Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102
243365007224	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_IV; cd01994
243365007225	Ligand Binding Site [chemical binding]; other site
243365007226	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
243365007227	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
243365007228	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
243365007229	dimerization interface [polypeptide binding]; other site
243365007230	active site
243365007231	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
243365007232	homopentamer interface [polypeptide binding]; other site
243365007233	active site
243365007234	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
243365007235	putative RNA binding site [nucleotide binding]; other site
243365007236	thiamine monophosphate kinase; Provisional; Region: PRK05731
243365007237	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
243365007238	ATP binding site [chemical binding]; other site
243365007239	dimerization interface [polypeptide binding]; other site
243365007240	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
243365007241	tetramer interfaces [polypeptide binding]; other site
243365007242	binuclear metal-binding site [ion binding]; other site
243365007243	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
243365007244	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
243365007245	putative chaperone; Provisional; Region: PRK11678
243365007246	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
243365007247	nucleotide binding site [chemical binding]; other site
243365007248	putative NEF/HSP70 interaction site [polypeptide binding]; other site
243365007249	SBD interface [polypeptide binding]; other site
243365007250	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
243365007251	Int/Topo IB signature motif; other site
243365007252	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
243365007253	active site
243365007254	Response regulator receiver domain; Region: Response_reg; pfam00072
243365007255	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365007256	active site
243365007257	phosphorylation site [posttranslational modification]
243365007258	intermolecular recognition site; other site
243365007259	dimerization interface [polypeptide binding]; other site
243365007260	Hpt domain; Region: Hpt; pfam01627
243365007261	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365007262	Response regulator receiver domain; Region: Response_reg; pfam00072
243365007263	active site
243365007264	phosphorylation site [posttranslational modification]
243365007265	intermolecular recognition site; other site
243365007266	dimerization interface [polypeptide binding]; other site
243365007267	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243365007268	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243365007269	substrate binding pocket [chemical binding]; other site
243365007270	membrane-bound complex binding site; other site
243365007271	hinge residues; other site
243365007272	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243365007273	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243365007274	dimer interface [polypeptide binding]; other site
243365007275	phosphorylation site [posttranslational modification]
243365007276	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365007277	ATP binding site [chemical binding]; other site
243365007278	Mg2+ binding site [ion binding]; other site
243365007279	G-X-G motif; other site
243365007280	Response regulator receiver domain; Region: Response_reg; pfam00072
243365007281	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365007282	active site
243365007283	phosphorylation site [posttranslational modification]
243365007284	intermolecular recognition site; other site
243365007285	dimerization interface [polypeptide binding]; other site
243365007286	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
243365007287	putative binding surface; other site
243365007288	active site
243365007289	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
243365007290	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365007291	intermolecular recognition site; other site
243365007292	active site
243365007293	dimerization interface [polypeptide binding]; other site
243365007294	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
243365007295	DNA binding residues [nucleotide binding]
243365007296	dimerization interface [polypeptide binding]; other site
243365007297	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
243365007298	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
243365007299	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
243365007300	RNA binding surface [nucleotide binding]; other site
243365007301	Pseudouridine synthase, a subgroup of the RsuA family; Region: PSSA_1; cd02555
243365007302	active site
243365007303	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
243365007304	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
243365007305	G1 box; other site
243365007306	putative GEF interaction site [polypeptide binding]; other site
243365007307	GTP/Mg2+ binding site [chemical binding]; other site
243365007308	Switch I region; other site
243365007309	G2 box; other site
243365007310	G3 box; other site
243365007311	Switch II region; other site
243365007312	G4 box; other site
243365007313	G5 box; other site
243365007314	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
243365007315	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
243365007316	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
243365007317	ATP cone domain; Region: ATP-cone; pfam03477
243365007318	Class III ribonucleotide reductase; Region: RNR_III; cd01675
243365007319	effector binding site; other site
243365007320	active site
243365007321	Zn binding site [ion binding]; other site
243365007322	glycine loop; other site
243365007323	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
243365007324	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
243365007325	putative sialic acid transporter; Region: 2A0112; TIGR00891
243365007326	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365007327	putative substrate translocation pore; other site
243365007328	putative type III secretion system effector protein OrgC; Provisional; Region: PRK15321
243365007329	invasion protein OrgB; Provisional; Region: PRK15322
243365007330	Bacterial type III secretion apparatus protein (OrgA_MxiK); Region: OrgA_MxiK; pfam09482
243365007331	invasion protein OrgA; Provisional; Region: PRK15323
243365007332	type III secretion system lipoprotein PrgK; Provisional; Region: PRK15324
243365007333	type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325
243365007334	Type III secretion needle MxiH like; Region: MxiH; cl09641
243365007335	type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327
243365007336	Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480
243365007337	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
243365007338	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
243365007339	C-terminal domain interface [polypeptide binding]; other site
243365007340	GSH binding site (G-site) [chemical binding]; other site
243365007341	dimer interface [polypeptide binding]; other site
243365007342	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
243365007343	N-terminal domain interface [polypeptide binding]; other site
243365007344	putative dimer interface [polypeptide binding]; other site
243365007345	active site
243365007346	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
243365007347	RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885
243365007348	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
243365007349	fructose-1,6-bisphosphatase family protein; Region: PLN02628
243365007350	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
243365007351	AMP binding site [chemical binding]; other site
243365007352	metal binding site [ion binding]; metal-binding site
243365007353	active site
243365007354	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243365007355	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
243365007356	membrane-bound complex binding site; other site
243365007357	hinge residues; other site
243365007358	ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682
243365007359	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
243365007360	putative Cl- selectivity filter; other site
243365007361	putative pore gating glutamate residue; other site
243365007362	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
243365007363	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
243365007364	active site
243365007365	ATP binding site [chemical binding]; other site
243365007366	substrate binding site [chemical binding]; other site
243365007367	activation loop (A-loop); other site
243365007368	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
243365007369	putative active site [active]
243365007370	putative metal binding site [ion binding]; other site
243365007371	CHAT domain; Region: CHAT; pfam12770
243365007372	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
243365007373	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
243365007374	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
243365007375	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
243365007376	dimerization interface [polypeptide binding]; other site
243365007377	putative DNA binding site [nucleotide binding]; other site
243365007378	putative Zn2+ binding site [ion binding]; other site
243365007379	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
243365007380	Low molecular weight phosphatase family; Region: LMWPc; cd00115
243365007381	active site
243365007382	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
243365007383	arsenical-resistance protein; Region: acr3; TIGR00832
243365007384	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
243365007385	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
243365007386	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
243365007387	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
243365007388	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
243365007389	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
243365007390	Cupin domain; Region: Cupin_2; cl17218
243365007391	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
243365007392	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204
243365007393	dimer interface [polypeptide binding]; other site
243365007394	active site
243365007395	CoA binding pocket [chemical binding]; other site
243365007396	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
243365007397	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243365007398	NAD(P) binding site [chemical binding]; other site
243365007399	active site
243365007400	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
243365007401	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
243365007402	putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304
243365007403	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
243365007404	active site
243365007405	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
243365007406	Fatty acid desaturase; Region: FA_desaturase; pfam00487
243365007407	putative di-iron ligands [ion binding]; other site
243365007408	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
243365007409	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
243365007410	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
243365007411	active site
243365007412	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
243365007413	multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575
243365007414	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243365007415	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
243365007416	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
243365007417	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
243365007418	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
243365007419	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
243365007420	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
243365007421	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
243365007422	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
243365007423	Walker A/P-loop; other site
243365007424	ATP binding site [chemical binding]; other site
243365007425	Q-loop/lid; other site
243365007426	ABC transporter signature motif; other site
243365007427	Walker B; other site
243365007428	D-loop; other site
243365007429	H-loop/switch region; other site
243365007430	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
243365007431	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
243365007432	Walker A/P-loop; other site
243365007433	ATP binding site [chemical binding]; other site
243365007434	Q-loop/lid; other site
243365007435	ABC transporter signature motif; other site
243365007436	Walker B; other site
243365007437	D-loop; other site
243365007438	H-loop/switch region; other site
243365007439	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
243365007440	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
243365007441	HlyD family secretion protein; Region: HlyD_3; pfam13437
243365007442	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868
243365007443	conserved hypothetical protein; Region: TIGR02285
243365007444	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
243365007445	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243365007446	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365007447	dimer interface [polypeptide binding]; other site
243365007448	putative CheW interface [polypeptide binding]; other site
243365007449	Predicted transcriptional regulators [Transcription]; Region: COG1695
243365007450	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
243365007451	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
243365007452	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
243365007453	FAD binding pocket [chemical binding]; other site
243365007454	FAD binding motif [chemical binding]; other site
243365007455	phosphate binding motif [ion binding]; other site
243365007456	NAD binding pocket [chemical binding]; other site
243365007457	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
243365007458	ligand binding site [chemical binding]; other site
243365007459	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
243365007460	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365007461	Coenzyme A binding pocket [chemical binding]; other site
243365007462	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
243365007463	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
243365007464	substrate binding site [chemical binding]; other site
243365007465	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
243365007466	substrate binding site [chemical binding]; other site
243365007467	ligand binding site [chemical binding]; other site
243365007468	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
243365007469	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365007470	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
243365007471	dimerization interface [polypeptide binding]; other site
243365007472	substrate binding pocket [chemical binding]; other site
243365007473	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
243365007474	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
243365007475	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
243365007476	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
243365007477	RmuC family; Region: RmuC; pfam02646
243365007478	Predicted ATPase [General function prediction only]; Region: COG3911
243365007479	AAA domain; Region: AAA_28; pfam13521
243365007480	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
243365007481	DHH family; Region: DHH; pfam01368
243365007482	DHHA1 domain; Region: DHHA1; pfam02272
243365007483	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255
243365007484	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
243365007485	Peptidase family M23; Region: Peptidase_M23; pfam01551
243365007486	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
243365007487	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
243365007488	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
243365007489	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
243365007490	ferrochelatase; Reviewed; Region: hemH; PRK00035
243365007491	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
243365007492	C-terminal domain interface [polypeptide binding]; other site
243365007493	active site
243365007494	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
243365007495	active site
243365007496	N-terminal domain interface [polypeptide binding]; other site
243365007497	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
243365007498	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
243365007499	dimerization interface [polypeptide binding]; other site
243365007500	ligand binding site [chemical binding]; other site
243365007501	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243365007502	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
243365007503	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
243365007504	Predicted membrane protein [Function unknown]; Region: COG2311
243365007505	enoyl-CoA hydratase; Provisional; Region: PRK06142
243365007506	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
243365007507	substrate binding site [chemical binding]; other site
243365007508	oxyanion hole (OAH) forming residues; other site
243365007509	trimer interface [polypeptide binding]; other site
243365007510	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
243365007511	CoenzymeA binding site [chemical binding]; other site
243365007512	subunit interaction site [polypeptide binding]; other site
243365007513	PHB binding site; other site
243365007514	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243365007515	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
243365007516	Site-specific recombinase; Region: SpecificRecomb; pfam10136
243365007517	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
243365007518	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
243365007519	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
243365007520	NAD(P) binding site [chemical binding]; other site
243365007521	catalytic residues [active]
243365007522	Cupin; Region: Cupin_6; pfam12852
243365007523	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
243365007524	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
243365007525	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
243365007526	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
243365007527	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
243365007528	flagellin; Provisional; Region: PRK12802
243365007529	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
243365007530	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
243365007531	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
243365007532	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
243365007533	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
243365007534	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365007535	active site
243365007536	phosphorylation site [posttranslational modification]
243365007537	intermolecular recognition site; other site
243365007538	dimerization interface [polypeptide binding]; other site
243365007539	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243365007540	Zn2+ binding site [ion binding]; other site
243365007541	Mg2+ binding site [ion binding]; other site
243365007542	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243365007543	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243365007544	dimer interface [polypeptide binding]; other site
243365007545	phosphorylation site [posttranslational modification]
243365007546	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365007547	ATP binding site [chemical binding]; other site
243365007548	Mg2+ binding site [ion binding]; other site
243365007549	G-X-G motif; other site
243365007550	Response regulator receiver domain; Region: Response_reg; pfam00072
243365007551	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365007552	active site
243365007553	phosphorylation site [posttranslational modification]
243365007554	intermolecular recognition site; other site
243365007555	dimerization interface [polypeptide binding]; other site
243365007556	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
243365007557	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365007558	active site
243365007559	phosphorylation site [posttranslational modification]
243365007560	intermolecular recognition site; other site
243365007561	dimerization interface [polypeptide binding]; other site
243365007562	FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198
243365007563	HD domain; Region: HD_3; pfam13023
243365007564	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
243365007565	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
243365007566	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
243365007567	dimer interface [polypeptide binding]; other site
243365007568	[2Fe-2S] cluster binding site [ion binding]; other site
243365007569	replicative DNA helicase; Provisional; Region: PRK05748
243365007570	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
243365007571	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
243365007572	Walker A motif; other site
243365007573	ATP binding site [chemical binding]; other site
243365007574	Walker B motif; other site
243365007575	DNA binding loops [nucleotide binding]
243365007576	HI0933-like protein; Region: HI0933_like; pfam03486
243365007577	superoxide dismutase; Provisional; Region: PRK10543
243365007578	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
243365007579	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
243365007580	Response regulator receiver domain; Region: Response_reg; pfam00072
243365007581	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365007582	active site
243365007583	phosphorylation site [posttranslational modification]
243365007584	intermolecular recognition site; other site
243365007585	dimerization interface [polypeptide binding]; other site
243365007586	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243365007587	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
243365007588	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365007589	active site
243365007590	phosphorylation site [posttranslational modification]
243365007591	intermolecular recognition site; other site
243365007592	dimerization interface [polypeptide binding]; other site
243365007593	CheB methylesterase; Region: CheB_methylest; pfam01339
243365007594	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
243365007595	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
243365007596	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
243365007597	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
243365007598	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
243365007599	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
243365007600	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365007601	dimer interface [polypeptide binding]; other site
243365007602	putative CheW interface [polypeptide binding]; other site
243365007603	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
243365007604	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
243365007605	putative binding surface; other site
243365007606	active site
243365007607	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
243365007608	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365007609	ATP binding site [chemical binding]; other site
243365007610	Mg2+ binding site [ion binding]; other site
243365007611	G-X-G motif; other site
243365007612	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
243365007613	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
243365007614	anti sigma factor interaction site; other site
243365007615	regulatory phosphorylation site [posttranslational modification]; other site
243365007616	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
243365007617	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365007618	active site
243365007619	phosphorylation site [posttranslational modification]
243365007620	intermolecular recognition site; other site
243365007621	dimerization interface [polypeptide binding]; other site
243365007622	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
243365007623	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365007624	dimer interface [polypeptide binding]; other site
243365007625	putative CheW interface [polypeptide binding]; other site
243365007626	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243365007627	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243365007628	substrate binding pocket [chemical binding]; other site
243365007629	membrane-bound complex binding site; other site
243365007630	hinge residues; other site
243365007631	amidophosphoribosyltransferase; Provisional; Region: PRK09246
243365007632	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
243365007633	active site
243365007634	tetramer interface [polypeptide binding]; other site
243365007635	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
243365007636	active site
243365007637	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
243365007638	Colicin V production protein; Region: Colicin_V; pfam02674
243365007639	Sporulation related domain; Region: SPOR; pfam05036
243365007640	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
243365007641	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
243365007642	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
243365007643	ABC transporter ATPase component; Reviewed; Region: PRK11147
243365007644	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243365007645	Walker A/P-loop; other site
243365007646	ATP binding site [chemical binding]; other site
243365007647	Q-loop/lid; other site
243365007648	ABC transporter signature motif; other site
243365007649	Walker B; other site
243365007650	D-loop; other site
243365007651	H-loop/switch region; other site
243365007652	ABC transporter; Region: ABC_tran_2; pfam12848
243365007653	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
243365007654	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243365007655	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243365007656	substrate binding pocket [chemical binding]; other site
243365007657	membrane-bound complex binding site; other site
243365007658	hinge residues; other site
243365007659	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_10; cd06319
243365007660	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
243365007661	putative ligand binding site [chemical binding]; other site
243365007662	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
243365007663	NlpC/P60 family; Region: NLPC_P60; pfam00877
243365007664	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
243365007665	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
243365007666	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
243365007667	structural tetrad; other site
243365007668	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
243365007669	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
243365007670	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
243365007671	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
243365007672	DNA binding residues [nucleotide binding]
243365007673	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
243365007674	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
243365007675	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
243365007676	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
243365007677	Protein of unknown function, DUF484; Region: DUF484; cl17449
243365007678	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
243365007679	EamA-like transporter family; Region: EamA; pfam00892
243365007680	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
243365007681	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243365007682	FeS/SAM binding site; other site
243365007683	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
243365007684	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
243365007685	Walker A motif; other site
243365007686	Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
243365007687	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
243365007688	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243365007689	dimerization interface [polypeptide binding]; other site
243365007690	GAF domain; Region: GAF_3; pfam13492
243365007691	Histidine kinase; Region: HisKA_3; pfam07730
243365007692	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365007693	ATP binding site [chemical binding]; other site
243365007694	Mg2+ binding site [ion binding]; other site
243365007695	G-X-G motif; other site
243365007696	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
243365007697	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365007698	active site
243365007699	phosphorylation site [posttranslational modification]
243365007700	intermolecular recognition site; other site
243365007701	dimerization interface [polypeptide binding]; other site
243365007702	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
243365007703	DNA binding residues [nucleotide binding]
243365007704	dimerization interface [polypeptide binding]; other site
243365007705	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
243365007706	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
243365007707	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
243365007708	4Fe-4S binding domain; Region: Fer4; cl02805
243365007709	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
243365007710	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
243365007711	[4Fe-4S] binding site [ion binding]; other site
243365007712	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
243365007713	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
243365007714	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
243365007715	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
243365007716	molybdopterin cofactor binding site; other site
243365007717	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
243365007718	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
243365007719	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365007720	putative substrate translocation pore; other site
243365007721	Protein of unknown function (DUF330); Region: DUF330; pfam03886
243365007722	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
243365007723	mce related protein; Region: MCE; pfam02470
243365007724	mce related protein; Region: MCE; pfam02470
243365007725	mce related protein; Region: MCE; pfam02470
243365007726	Paraquat-inducible protein A; Region: PqiA; pfam04403
243365007727	Paraquat-inducible protein A; Region: PqiA; pfam04403
243365007728	Pathogenicity locus; Region: Cdd1; pfam11731
243365007729	hypothetical protein; Provisional; Region: PRK10621
243365007730	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
243365007731	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365007732	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365007733	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
243365007734	putative effector binding pocket; other site
243365007735	dimerization interface [polypeptide binding]; other site
243365007736	SurA N-terminal domain; Region: SurA_N_3; cl07813
243365007737	periplasmic folding chaperone; Provisional; Region: PRK10788
243365007738	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
243365007739	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
243365007740	IHF dimer interface [polypeptide binding]; other site
243365007741	IHF - DNA interface [nucleotide binding]; other site
243365007742	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
243365007743	Found in ATP-dependent protease La (LON); Region: LON; smart00464
243365007744	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243365007745	Walker A motif; other site
243365007746	ATP binding site [chemical binding]; other site
243365007747	Walker B motif; other site
243365007748	arginine finger; other site
243365007749	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
243365007750	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
243365007751	HTH-like domain; Region: HTH_21; pfam13276
243365007752	Integrase core domain; Region: rve; pfam00665
243365007753	Integrase core domain; Region: rve_3; pfam13683
243365007754	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
243365007755	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
243365007756	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243365007757	Walker A motif; other site
243365007758	ATP binding site [chemical binding]; other site
243365007759	Walker B motif; other site
243365007760	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
243365007761	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
243365007762	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
243365007763	oligomer interface [polypeptide binding]; other site
243365007764	active site residues [active]
243365007765	trigger factor; Provisional; Region: tig; PRK01490
243365007766	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
243365007767	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
243365007768	Bacterial Ig-like domain; Region: Big_5; pfam13205
243365007769	Mab-21 protein; Region: Mab-21; pfam03281
243365007770	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
243365007771	MG2 domain; Region: A2M_N; pfam01835
243365007772	Alpha-2-macroglobulin family; Region: A2M; pfam00207
243365007773	Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990
243365007774	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
243365007775	Transglycosylase; Region: Transgly; pfam00912
243365007776	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
243365007777	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
243365007778	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
243365007779	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
243365007780	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243365007781	NAD(P) binding site [chemical binding]; other site
243365007782	active site
243365007783	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365007784	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365007785	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
243365007786	Lysine efflux permease [General function prediction only]; Region: COG1279
243365007787	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
243365007788	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365007789	metal binding site [ion binding]; metal-binding site
243365007790	active site
243365007791	I-site; other site
243365007792	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243365007793	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
243365007794	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365007795	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
243365007796	dimerization interface [polypeptide binding]; other site
243365007797	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
243365007798	active site
243365007799	catalytic motif [active]
243365007800	Zn binding site [ion binding]; other site
243365007801	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
243365007802	Peptidase family M23; Region: Peptidase_M23; pfam01551
243365007803	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
243365007804	PAS domain; Region: PAS_9; pfam13426
243365007805	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365007806	putative active site [active]
243365007807	heme pocket [chemical binding]; other site
243365007808	PAS fold; Region: PAS_4; pfam08448
243365007809	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365007810	putative active site [active]
243365007811	heme pocket [chemical binding]; other site
243365007812	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365007813	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365007814	metal binding site [ion binding]; metal-binding site
243365007815	active site
243365007816	I-site; other site
243365007817	pathogenicity island 2 effector protein SseE; Provisional; Region: PRK15360
243365007818	pathogenicity island 2 effector protein SseD; Provisional; Region: PRK15361
243365007819	pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362
243365007820	type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552
243365007821	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243365007822	binding surface
243365007823	TPR motif; other site
243365007824	EspA-like secreted protein; Region: EspA; cl04069
243365007825	EspA-like secreted protein; Region: EspA; cl04069
243365007826	EspA-like secreted protein; Region: EspA; pfam03433
243365007827	EspA-like secreted protein; Region: EspA; cl04069
243365007828	EspA-like secreted protein; Region: EspA; cl04069
243365007829	EspA-like secreted protein; Region: EspA; pfam03433
243365007830	Helix-turn-helix domain; Region: HTH_18; pfam12833
243365007831	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
243365007832	Type III secretion needle MxiH like; Region: MxiH; cl09641
243365007833	type III secretion system protein, SsaH family; Region: type_III_ssaH; TIGR02498
243365007834	type III secretion apparatus protein, YscI/HrpB, C-terminal domain; Region: yscI_hrpB_dom; TIGR02497
243365007835	type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544
243365007836	Type III secretion system subunit; Region: T3SS_LEE_assoc; pfam13327
243365007837	type III secretion system protein SsaL; Provisional; Region: PRK15345
243365007838	type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568
243365007839	type III secretion effector delivery regulator, TyeA family; Region: type_III_tyeA; TIGR02511
243365007840	Chitin binding domain; Region: Chitin_bind_3; pfam03067
243365007841	chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214
243365007842	type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499
243365007843	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
243365007844	type III secretion system protein, YseE family; Region: type_III_yscE; TIGR02501
243365007845	type III secretion system protein SsaD; Provisional; Region: PRK15367
243365007846	type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500
243365007847	outer membrane secretin SsaC; Provisional; Region: PRK15346
243365007848	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
243365007849	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
243365007850	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
243365007851	two component system sensor kinase SsrB; Provisional; Region: PRK15369
243365007852	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365007853	active site
243365007854	phosphorylation site [posttranslational modification]
243365007855	intermolecular recognition site; other site
243365007856	dimerization interface [polypeptide binding]; other site
243365007857	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
243365007858	DNA binding residues [nucleotide binding]
243365007859	dimerization interface [polypeptide binding]; other site
243365007860	two component system sensor kinase SsrA; Provisional; Region: PRK15347
243365007861	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243365007862	dimerization interface [polypeptide binding]; other site
243365007863	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
243365007864	dimer interface [polypeptide binding]; other site
243365007865	phosphorylation site [posttranslational modification]
243365007866	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365007867	ATP binding site [chemical binding]; other site
243365007868	Mg2+ binding site [ion binding]; other site
243365007869	G-X-G motif; other site
243365007870	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365007871	active site
243365007872	phosphorylation site [posttranslational modification]
243365007873	intermolecular recognition site; other site
243365007874	dimerization interface [polypeptide binding]; other site
243365007875	Hpt domain; Region: Hpt; pfam01627
243365007876	type III secretion chaperone SycN; Region: type_III_SycN; TIGR02503
243365007877	secretion system apparatus protein SsaV; Provisional; Region: PRK12720
243365007878	FHIPEP family; Region: FHIPEP; pfam00771
243365007879	type III secretion system ATPase; Validated; Region: PRK06820
243365007880	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
243365007881	Walker A motif/ATP binding site; other site
243365007882	Walker B motif; other site
243365007883	type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551
243365007884	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
243365007885	type III secretion system protein YscR; Provisional; Region: PRK12797
243365007886	Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794
243365007887	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
243365007888	secretion system apparatus protein SsaU; Reviewed; Region: PRK12721
243365007889	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
243365007890	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
243365007891	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
243365007892	N-acetyl-D-glucosamine binding site [chemical binding]; other site
243365007893	catalytic residue [active]
243365007894	Y-family of DNA polymerases; Region: PolY; cl12025
243365007895	DNA binding site [nucleotide binding]
243365007896	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
243365007897	Cupin domain; Region: Cupin_2; pfam07883
243365007898	putative acyl carrier protein IacP; Validated; Region: PRK08172
243365007899	Salmonella invasion protein A; Region: SipA; pfam09052
243365007900	Invasion plasmid antigen IpaD; Region: IpaD; pfam06511
243365007901	pathogenicity island 1 effector protein SipC; Provisional; Region: PRK15373
243365007902	pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374
243365007903	chaperone protein SicA; Provisional; Region: PRK15331
243365007904	Tetratricopeptide repeat; Region: TPR_3; pfam07720
243365007905	Tetratricopeptide repeat; Region: TPR_3; pfam07720
243365007906	type III secretion system protein SpaS; Validated; Region: PRK08156
243365007907	type III secretion system protein SpaR; Provisional; Region: PRK15332
243365007908	type III secretion system protein SpaQ; Provisional; Region: PRK15333
243365007909	type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796
243365007910	type III secretion system protein SpaO; Validated; Region: PRK08158
243365007911	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
243365007912	Surface presentation of antigens protein; Region: SPAN; pfam02510
243365007913	Salmonella surface presentation of antigen gene type M protein; Region: SPAM; cl03442
243365007914	ATP synthase SpaL; Validated; Region: PRK08149
243365007915	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
243365007916	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
243365007917	Walker A motif; other site
243365007918	ATP binding site [chemical binding]; other site
243365007919	Walker B motif; other site
243365007920	type III secretion system chaperone SpaK; Provisional; Region: PRK15336
243365007921	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
243365007922	type III secretion system protein InvA; Provisional; Region: PRK15337
243365007923	type III secretion system regulator InvE; Provisional; Region: PRK15338
243365007924	HrpJ-like domain; Region: HrpJ; cl15454
243365007925	type III secretion system outer membrane pore InvG; Provisional; Region: PRK15339
243365007926	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
243365007927	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
243365007928	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
243365007929	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
243365007930	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243365007931	dimer interface [polypeptide binding]; other site
243365007932	phosphorylation site [posttranslational modification]
243365007933	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365007934	ATP binding site [chemical binding]; other site
243365007935	Mg2+ binding site [ion binding]; other site
243365007936	G-X-G motif; other site
243365007937	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
243365007938	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365007939	active site
243365007940	phosphorylation site [posttranslational modification]
243365007941	intermolecular recognition site; other site
243365007942	dimerization interface [polypeptide binding]; other site
243365007943	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
243365007944	DNA binding site [nucleotide binding]
243365007945	disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657
243365007946	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
243365007947	dimerization domain [polypeptide binding]; other site
243365007948	dimer interface [polypeptide binding]; other site
243365007949	catalytic residues [active]
243365007950	invasion protein regulator; Provisional; Region: PRK12370
243365007951	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
243365007952	DNA binding site [nucleotide binding]
243365007953	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243365007954	TPR motif; other site
243365007955	binding surface
243365007956	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
243365007957	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
243365007958	N-acetyl-D-glucosamine binding site [chemical binding]; other site
243365007959	catalytic residue [active]
243365007960	YccA-like proteins; Region: YccA_like; cd10433
243365007961	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
243365007962	PAS fold; Region: PAS_3; pfam08447
243365007963	PAS fold; Region: PAS_4; pfam08448
243365007964	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365007965	putative active site [active]
243365007966	heme pocket [chemical binding]; other site
243365007967	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365007968	PAS domain; Region: PAS_9; pfam13426
243365007969	putative active site [active]
243365007970	heme pocket [chemical binding]; other site
243365007971	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243365007972	dimer interface [polypeptide binding]; other site
243365007973	phosphorylation site [posttranslational modification]
243365007974	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365007975	ATP binding site [chemical binding]; other site
243365007976	Mg2+ binding site [ion binding]; other site
243365007977	G-X-G motif; other site
243365007978	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365007979	active site
243365007980	phosphorylation site [posttranslational modification]
243365007981	intermolecular recognition site; other site
243365007982	dimerization interface [polypeptide binding]; other site
243365007983	Response regulator receiver domain; Region: Response_reg; pfam00072
243365007984	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365007985	active site
243365007986	phosphorylation site [posttranslational modification]
243365007987	intermolecular recognition site; other site
243365007988	dimerization interface [polypeptide binding]; other site
243365007989	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
243365007990	Response regulator receiver domain; Region: Response_reg; pfam00072
243365007991	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365007992	active site
243365007993	phosphorylation site [posttranslational modification]
243365007994	intermolecular recognition site; other site
243365007995	dimerization interface [polypeptide binding]; other site
243365007996	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
243365007997	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
243365007998	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
243365007999	anti sigma factor interaction site; other site
243365008000	regulatory phosphorylation site [posttranslational modification]; other site
243365008001	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
243365008002	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365008003	dimer interface [polypeptide binding]; other site
243365008004	putative CheW interface [polypeptide binding]; other site
243365008005	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
243365008006	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
243365008007	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
243365008008	catalytic residue [active]
243365008009	DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086
243365008010	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365008011	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
243365008012	substrate binding pocket [chemical binding]; other site
243365008013	dimerization interface [polypeptide binding]; other site
243365008014	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
243365008015	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
243365008016	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
243365008017	dimer interface [polypeptide binding]; other site
243365008018	putative tRNA-binding site [nucleotide binding]; other site
243365008019	Cupin domain; Region: Cupin_2; pfam07883
243365008020	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
243365008021	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
243365008022	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
243365008023	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
243365008024	Cytochrome P450; Region: p450; cl12078
243365008025	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
243365008026	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346
243365008027	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
243365008028	CoenzymeA binding site [chemical binding]; other site
243365008029	subunit interaction site [polypeptide binding]; other site
243365008030	PHB binding site; other site
243365008031	Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387
243365008032	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
243365008033	PAAR motif; Region: PAAR_motif; pfam05488
243365008034	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
243365008035	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
243365008036	N-acetyl-D-glucosamine binding site [chemical binding]; other site
243365008037	catalytic residue [active]
243365008038	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
243365008039	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
243365008040	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
243365008041	active site
243365008042	HIGH motif; other site
243365008043	nucleotide binding site [chemical binding]; other site
243365008044	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
243365008045	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
243365008046	active site
243365008047	KMSKS motif; other site
243365008048	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
243365008049	tRNA binding surface [nucleotide binding]; other site
243365008050	anticodon binding site; other site
243365008051	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
243365008052	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
243365008053	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
243365008054	active site
243365008055	cellulose biosynthesis protein BcsE; Region: cellulose_bcsE; TIGR03369
243365008056	cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368
243365008057	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
243365008058	endo-1,4-D-glucanase; Provisional; Region: PRK11097
243365008059	cellulose synthase regulator protein; Provisional; Region: PRK11114
243365008060	cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498
243365008061	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
243365008062	DXD motif; other site
243365008063	PilZ domain; Region: PilZ; pfam07238
243365008064	cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371
243365008065	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
243365008066	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
243365008067	Predicted membrane protein [Function unknown]; Region: COG4125
243365008068	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
243365008069	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
243365008070	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365008071	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365008072	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
243365008073	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
243365008074	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
243365008075	Walker A/P-loop; other site
243365008076	ATP binding site [chemical binding]; other site
243365008077	Q-loop/lid; other site
243365008078	ABC transporter signature motif; other site
243365008079	Walker B; other site
243365008080	D-loop; other site
243365008081	H-loop/switch region; other site
243365008082	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
243365008083	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
243365008084	Walker A/P-loop; other site
243365008085	ATP binding site [chemical binding]; other site
243365008086	Q-loop/lid; other site
243365008087	ABC transporter signature motif; other site
243365008088	Walker B; other site
243365008089	D-loop; other site
243365008090	H-loop/switch region; other site
243365008091	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
243365008092	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
243365008093	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
243365008094	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365008095	dimer interface [polypeptide binding]; other site
243365008096	conserved gate region; other site
243365008097	putative PBP binding loops; other site
243365008098	ABC-ATPase subunit interface; other site
243365008099	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
243365008100	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365008101	dimer interface [polypeptide binding]; other site
243365008102	conserved gate region; other site
243365008103	putative PBP binding loops; other site
243365008104	ABC-ATPase subunit interface; other site
243365008105	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_18; cd08505
243365008106	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
243365008107	short chain dehydrogenase; Provisional; Region: PRK05993
243365008108	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
243365008109	NADP binding site [chemical binding]; other site
243365008110	active site
243365008111	steroid binding site; other site
243365008112	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
243365008113	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
243365008114	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
243365008115	substrate binding pocket [chemical binding]; other site
243365008116	chain length determination region; other site
243365008117	substrate-Mg2+ binding site; other site
243365008118	catalytic residues [active]
243365008119	aspartate-rich region 1; other site
243365008120	active site lid residues [active]
243365008121	aspartate-rich region 2; other site
243365008122	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
243365008123	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
243365008124	TPP-binding site; other site
243365008125	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
243365008126	PYR/PP interface [polypeptide binding]; other site
243365008127	dimer interface [polypeptide binding]; other site
243365008128	TPP binding site [chemical binding]; other site
243365008129	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
243365008130	Predicted small integral membrane protein (DUF2165); Region: DUF2165; pfam09933
243365008131	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
243365008132	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
243365008133	metal binding site [ion binding]; metal-binding site
243365008134	dimer interface [polypeptide binding]; other site
243365008135	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
243365008136	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
243365008137	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
243365008138	SnoaL-like domain; Region: SnoaL_2; pfam12680
243365008139	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243365008140	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
243365008141	This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335
243365008142	putative deacylase active site [active]
243365008143	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
243365008144	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
243365008145	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
243365008146	Walker A/P-loop; other site
243365008147	ATP binding site [chemical binding]; other site
243365008148	Q-loop/lid; other site
243365008149	ABC transporter signature motif; other site
243365008150	Walker B; other site
243365008151	D-loop; other site
243365008152	H-loop/switch region; other site
243365008153	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
243365008154	FtsX-like permease family; Region: FtsX; pfam02687
243365008155	macrolide transporter subunit MacA; Provisional; Region: PRK11578
243365008156	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
243365008157	HlyD family secretion protein; Region: HlyD_3; pfam13437
243365008158	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365008159	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365008160	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
243365008161	putative effector binding pocket; other site
243365008162	putative dimerization interface [polypeptide binding]; other site
243365008163	short chain dehydrogenase; Provisional; Region: PRK12744
243365008164	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
243365008165	NADP binding site [chemical binding]; other site
243365008166	homodimer interface [polypeptide binding]; other site
243365008167	active site
243365008168	substrate binding site [chemical binding]; other site
243365008169	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
243365008170	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
243365008171	ligand binding site [chemical binding]; other site
243365008172	flexible hinge region; other site
243365008173	putative switch regulator; other site
243365008174	helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419
243365008175	non-specific DNA interactions [nucleotide binding]; other site
243365008176	DNA binding site [nucleotide binding]
243365008177	sequence specific DNA binding site [nucleotide binding]; other site
243365008178	putative cAMP binding site [chemical binding]; other site
243365008179	Hemerythrin-like domain; Region: Hr-like; cd12108
243365008180	NnrS protein; Region: NnrS; pfam05940
243365008181	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
243365008182	active site
243365008183	ribulose/triose binding site [chemical binding]; other site
243365008184	phosphate binding site [ion binding]; other site
243365008185	substrate (anthranilate) binding pocket [chemical binding]; other site
243365008186	product (indole) binding pocket [chemical binding]; other site
243365008187	lipase chaperone; Provisional; Region: PRK01294
243365008188	Proteobacterial lipase chaperone protein; Region: Lipase_chap; pfam03280
243365008189	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
243365008190	Lipase (class 2); Region: Lipase_2; pfam01674
243365008191	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
243365008192	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
243365008193	nucleophile elbow; other site
243365008194	Surface antigen; Region: Bac_surface_Ag; pfam01103
243365008195	PilZ domain; Region: PilZ; pfam07238
243365008196	Peptidase S8 family domain in Protein convertases; Region: Peptidases_S8_Protein_convertases_Kexins_Furin-lik; cd04059
243365008197	calcium binding site 1 [ion binding]; other site
243365008198	active site
243365008199	catalytic triad [active]
243365008200	calcium binding site 2 [ion binding]; other site
243365008201	calcium binding site 3 [ion binding]; other site
243365008202	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
243365008203	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
243365008204	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
243365008205	dimer interface [polypeptide binding]; other site
243365008206	active site
243365008207	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
243365008208	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
243365008209	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
243365008210	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
243365008211	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
243365008212	substrate binding site [chemical binding]; other site
243365008213	oxyanion hole (OAH) forming residues; other site
243365008214	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
243365008215	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
243365008216	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
243365008217	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
243365008218	active site
243365008219	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
243365008220	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243365008221	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
243365008222	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
243365008223	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
243365008224	homodimer interface [polypeptide binding]; other site
243365008225	substrate-cofactor binding pocket; other site
243365008226	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365008227	catalytic residue [active]
243365008228	MarR family; Region: MarR_2; pfam12802
243365008229	Protein of unknown function, DUF488; Region: DUF488; cl01246
243365008230	putative alcohol dehydrogenase; Provisional; Region: PRK09860
243365008231	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
243365008232	dimer interface [polypeptide binding]; other site
243365008233	active site
243365008234	metal binding site [ion binding]; metal-binding site
243365008235	MarC family integral membrane protein; Region: MarC; cl00919
243365008236	lysine transporter; Provisional; Region: PRK10836
243365008237	potassium uptake protein; Region: kup; TIGR00794
243365008238	K+ potassium transporter; Region: K_trans; pfam02705
243365008239	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
243365008240	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
243365008241	HlyD family secretion protein; Region: HlyD_3; pfam13437
243365008242	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
243365008243	Protein export membrane protein; Region: SecD_SecF; cl14618
243365008244	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
243365008245	Protein export membrane protein; Region: SecD_SecF; cl14618
243365008246	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
243365008247	active site
243365008248	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243365008249	Walker A motif; other site
243365008250	ATP binding site [chemical binding]; other site
243365008251	Walker B motif; other site
243365008252	arginine finger; other site
243365008253	bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533
243365008254	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
243365008255	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
243365008256	C-terminal domain interface [polypeptide binding]; other site
243365008257	GSH binding site (G-site) [chemical binding]; other site
243365008258	dimer interface [polypeptide binding]; other site
243365008259	C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178
243365008260	dimer interface [polypeptide binding]; other site
243365008261	N-terminal domain interface [polypeptide binding]; other site
243365008262	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
243365008263	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK12457
243365008264	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
243365008265	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
243365008266	Hemerythrin-like domain; Region: Hr-like; cd12108
243365008267	Methyltransferase domain; Region: Methyltransf_23; pfam13489
243365008268	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365008269	S-adenosylmethionine binding site [chemical binding]; other site
243365008270	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
243365008271	active site
243365008272	catalytic site [active]
243365008273	substrate binding site [chemical binding]; other site
243365008274	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
243365008275	hypothetical protein; Provisional; Region: PRK09256
243365008276	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
243365008277	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
243365008278	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
243365008279	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
243365008280	NADH dehydrogenase subunit B; Validated; Region: PRK06411
243365008281	OsmC-like protein; Region: OsmC; cl00767
243365008282	UGMP family protein; Validated; Region: PRK09604
243365008283	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
243365008284	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
243365008285	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
243365008286	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
243365008287	ABC transporter; Region: ABC_tran_2; pfam12848
243365008288	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
243365008289	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243365008290	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
243365008291	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
243365008292	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
243365008293	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
243365008294	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
243365008295	substrate binding site [chemical binding]; other site
243365008296	active site
243365008297	catalytic residues [active]
243365008298	heterodimer interface [polypeptide binding]; other site
243365008299	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
243365008300	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
243365008301	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365008302	catalytic residue [active]
243365008303	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
243365008304	active site
243365008305	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
243365008306	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
243365008307	dimerization interface 3.5A [polypeptide binding]; other site
243365008308	active site
243365008309	FimV N-terminal domain; Region: FimV_core; TIGR03505
243365008310	FimV N-terminal domain; Region: FimV_core; TIGR03505
243365008311	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
243365008312	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
243365008313	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
243365008314	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
243365008315	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
243365008316	Protein of unknown function (DUF3955); Region: DUF3955; pfam13127
243365008317	Protein of unknown function (DUF4243); Region: DUF4243; pfam14027
243365008318	Protein of unknown function (DUF3955); Region: DUF3955; pfam13127
243365008319	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
243365008320	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
243365008321	tartrate dehydrogenase; Region: TTC; TIGR02089
243365008322	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
243365008323	Uncharacterized conserved protein [Function unknown]; Region: COG3791
243365008324	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
243365008325	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
243365008326	substrate binding site [chemical binding]; other site
243365008327	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
243365008328	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
243365008329	substrate binding site [chemical binding]; other site
243365008330	ligand binding site [chemical binding]; other site
243365008331	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
243365008332	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
243365008333	sequence-specific DNA binding site [nucleotide binding]; other site
243365008334	salt bridge; other site
243365008335	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365008336	putative substrate translocation pore; other site
243365008337	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
243365008338	RNA binding surface [nucleotide binding]; other site
243365008339	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
243365008340	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
243365008341	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
243365008342	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
243365008343	putative acyltransferase; Provisional; Region: PRK05790
243365008344	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
243365008345	dimer interface [polypeptide binding]; other site
243365008346	active site
243365008347	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
243365008348	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243365008349	motif II; other site
243365008350	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
243365008351	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
243365008352	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
243365008353	DNA binding residues [nucleotide binding]
243365008354	dimer interface [polypeptide binding]; other site
243365008355	[2Fe-2S] cluster binding site [ion binding]; other site
243365008356	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
243365008357	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
243365008358	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
243365008359	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
243365008360	active site
243365008361	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
243365008362	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
243365008363	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
243365008364	active site
243365008365	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365008366	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365008367	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
243365008368	putative effector binding pocket; other site
243365008369	dimerization interface [polypeptide binding]; other site
243365008370	H+ Antiporter protein; Region: 2A0121; TIGR00900
243365008371	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
243365008372	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
243365008373	Condensation domain; Region: Condensation; pfam00668
243365008374	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
243365008375	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
243365008376	acyl-activating enzyme (AAE) consensus motif; other site
243365008377	AMP binding site [chemical binding]; other site
243365008378	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
243365008379	Condensation domain; Region: Condensation; pfam00668
243365008380	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
243365008381	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
243365008382	acyl-activating enzyme (AAE) consensus motif; other site
243365008383	AMP binding site [chemical binding]; other site
243365008384	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
243365008385	Condensation domain; Region: Condensation; pfam00668
243365008386	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
243365008387	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
243365008388	acyl-activating enzyme (AAE) consensus motif; other site
243365008389	AMP binding site [chemical binding]; other site
243365008390	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
243365008391	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
243365008392	Condensation domain; Region: Condensation; pfam00668
243365008393	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
243365008394	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
243365008395	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
243365008396	acyl-activating enzyme (AAE) consensus motif; other site
243365008397	AMP binding site [chemical binding]; other site
243365008398	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
243365008399	Condensation domain; Region: Condensation; pfam00668
243365008400	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
243365008401	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
243365008402	acyl-activating enzyme (AAE) consensus motif; other site
243365008403	AMP binding site [chemical binding]; other site
243365008404	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
243365008405	Condensation domain; Region: Condensation; pfam00668
243365008406	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
243365008407	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
243365008408	acyl-activating enzyme (AAE) consensus motif; other site
243365008409	AMP binding site [chemical binding]; other site
243365008410	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
243365008411	diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264
243365008412	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
243365008413	inhibitor-cofactor binding pocket; inhibition site
243365008414	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365008415	catalytic residue [active]
243365008416	Transposase; Region: HTH_Tnp_1; cl17663
243365008417	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243365008418	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243365008419	substrate binding pocket [chemical binding]; other site
243365008420	membrane-bound complex binding site; other site
243365008421	hinge residues; other site
243365008422	beta-lactam binding protein AmpH; Provisional; Region: PRK10662
243365008423	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
243365008424	Putative catalytic domain of Synechocystis sp. Sll1306 protein and other bacterial homologs; Region: CE4_Sll1306_like; cd10978
243365008425	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
243365008426	putative active site [active]
243365008427	putative catalytic site [active]
243365008428	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243365008429	short chain dehydrogenase; Provisional; Region: PRK07041
243365008430	NAD(P) binding site [chemical binding]; other site
243365008431	active site
243365008432	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
243365008433	thioredoxin reductase; Provisional; Region: PRK10262
243365008434	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
243365008435	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
243365008436	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
243365008437	Smr domain; Region: Smr; pfam01713
243365008438	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
243365008439	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
243365008440	catalytic triad [active]
243365008441	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
243365008442	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
243365008443	putative active site [active]
243365008444	PhoH-like protein; Region: PhoH; pfam02562
243365008445	Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223
243365008446	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
243365008447	active site
243365008448	cosubstrate binding site; other site
243365008449	substrate binding site [chemical binding]; other site
243365008450	catalytic site [active]
243365008451	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
243365008452	aminotransferase; Validated; Region: PRK07046
243365008453	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
243365008454	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
243365008455	catalytic residue [active]
243365008456	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
243365008457	DNA binding residues [nucleotide binding]
243365008458	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243365008459	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243365008460	substrate binding pocket [chemical binding]; other site
243365008461	membrane-bound complex binding site; other site
243365008462	hinge residues; other site
243365008463	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
243365008464	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
243365008465	dimerization interface [polypeptide binding]; other site
243365008466	ligand binding site [chemical binding]; other site
243365008467	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
243365008468	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
243365008469	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
243365008470	dimer interface [polypeptide binding]; other site
243365008471	NADP binding site [chemical binding]; other site
243365008472	catalytic residues [active]
243365008473	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
243365008474	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
243365008475	inhibitor site; inhibition site
243365008476	active site
243365008477	dimer interface [polypeptide binding]; other site
243365008478	catalytic residue [active]
243365008479	hydroxyproline-2-epimerase; Provisional; Region: PRK13970
243365008480	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
243365008481	PAS fold; Region: PAS_4; pfam08448
243365008482	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
243365008483	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
243365008484	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
243365008485	Uncharacterized conserved protein [Function unknown]; Region: COG3379
243365008486	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
243365008487	Ferritin-like; Region: Ferritin-like; pfam12902
243365008488	3-dehydroquinate synthase; Reviewed; Region: aroB; PRK06203
243365008489	active site
243365008490	NAD binding site [chemical binding]; other site
243365008491	metal binding site [ion binding]; metal-binding site
243365008492	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
243365008493	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
243365008494	active site
243365008495	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
243365008496	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
243365008497	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
243365008498	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
243365008499	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
243365008500	putative DNA binding site [nucleotide binding]; other site
243365008501	putative Zn2+ binding site [ion binding]; other site
243365008502	AsnC family; Region: AsnC_trans_reg; pfam01037
243365008503	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
243365008504	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
243365008505	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
243365008506	HflX GTPase family; Region: HflX; cd01878
243365008507	G1 box; other site
243365008508	GTP/Mg2+ binding site [chemical binding]; other site
243365008509	Switch I region; other site
243365008510	G2 box; other site
243365008511	G3 box; other site
243365008512	Switch II region; other site
243365008513	G4 box; other site
243365008514	G5 box; other site
243365008515	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
243365008516	DEAD-like helicases superfamily; Region: DEXDc; smart00487
243365008517	ATP binding site [chemical binding]; other site
243365008518	Mg++ binding site [ion binding]; other site
243365008519	motif III; other site
243365008520	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243365008521	nucleotide binding region [chemical binding]; other site
243365008522	ATP-binding site [chemical binding]; other site
243365008523	Uncharacterized conserved protein [Function unknown]; Region: COG5649
243365008524	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
243365008525	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
243365008526	active site
243365008527	nucleophile elbow; other site
243365008528	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
243365008529	MarR family; Region: MarR_2; pfam12802
243365008530	Fusaric acid resistance protein family; Region: FUSC; pfam04632
243365008531	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
243365008532	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
243365008533	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
243365008534	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
243365008535	HlyD family secretion protein; Region: HlyD_3; pfam13437
243365008536	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
243365008537	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
243365008538	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
243365008539	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
243365008540	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
243365008541	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
243365008542	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243365008543	dimerization interface [polypeptide binding]; other site
243365008544	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365008545	dimer interface [polypeptide binding]; other site
243365008546	putative CheW interface [polypeptide binding]; other site
243365008547	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
243365008548	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
243365008549	ATP binding site [chemical binding]; other site
243365008550	Mg++ binding site [ion binding]; other site
243365008551	motif III; other site
243365008552	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243365008553	nucleotide binding region [chemical binding]; other site
243365008554	ATP-binding site [chemical binding]; other site
243365008555	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
243365008556	putative RNA binding site [nucleotide binding]; other site
243365008557	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
243365008558	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
243365008559	active site
243365008560	catalytic site [active]
243365008561	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
243365008562	taurine dioxygenase; Reviewed; Region: tauD; PRK09553
243365008563	active site
243365008564	iron coordination sites [ion binding]; other site
243365008565	substrate binding pocket [chemical binding]; other site
243365008566	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
243365008567	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365008568	dimer interface [polypeptide binding]; other site
243365008569	conserved gate region; other site
243365008570	putative PBP binding loops; other site
243365008571	ABC-ATPase subunit interface; other site
243365008572	taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248
243365008573	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
243365008574	Walker A/P-loop; other site
243365008575	ATP binding site [chemical binding]; other site
243365008576	Q-loop/lid; other site
243365008577	ABC transporter signature motif; other site
243365008578	Walker B; other site
243365008579	D-loop; other site
243365008580	H-loop/switch region; other site
243365008581	ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521
243365008582	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243365008583	substrate binding pocket [chemical binding]; other site
243365008584	membrane-bound complex binding site; other site
243365008585	hinge residues; other site
243365008586	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
243365008587	HAMP domain; Region: HAMP; pfam00672
243365008588	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365008589	dimer interface [polypeptide binding]; other site
243365008590	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
243365008591	putative CheW interface [polypeptide binding]; other site
243365008592	hypothetical protein; Provisional; Region: PRK11212
243365008593	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
243365008594	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
243365008595	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
243365008596	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
243365008597	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
243365008598	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
243365008599	amphipathic channel; other site
243365008600	Asn-Pro-Ala signature motifs; other site
243365008601	Predicted membrane protein [Function unknown]; Region: COG1238
243365008602	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
243365008603	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
243365008604	protein-splicing catalytic site; other site
243365008605	thioester formation/cholesterol transfer; other site
243365008606	Pretoxin HINT domain; Region: PT-HINT; pfam07591
243365008607	adhesin HecA family 20-residue repeat (two copies); Region: fil_hemag_20aa; TIGR01731
243365008608	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
243365008609	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
243365008610	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
243365008611	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
243365008612	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
243365008613	Cytotoxic; Region: Cytotoxic; pfam09000
243365008614	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
243365008615	haemagglutination activity domain; Region: Haemagg_act; pfam05860
243365008616	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
243365008617	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
243365008618	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
243365008619	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
243365008620	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
243365008621	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
243365008622	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
243365008623	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
243365008624	arginine decarboxylase; Provisional; Region: PRK05354
243365008625	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
243365008626	active site
243365008627	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
243365008628	dimer interface [polypeptide binding]; other site
243365008629	catalytic residues [active]
243365008630	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
243365008631	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
243365008632	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
243365008633	putative active site [active]
243365008634	Zn binding site [ion binding]; other site
243365008635	flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550
243365008636	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
243365008637	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
243365008638	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147
243365008639	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
243365008640	Rod binding protein; Region: Rod-binding; cl01626
243365008641	flagellar rod assembly protein/muramidase FlgJ; Region: flagell_FlgJ; TIGR02541
243365008642	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
243365008643	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
243365008644	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
243365008645	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
243365008646	Flagellar L-ring protein; Region: FlgH; pfam02107
243365008647	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
243365008648	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
243365008649	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
243365008650	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
243365008651	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
243365008652	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
243365008653	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
243365008654	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
243365008655	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
243365008656	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
243365008657	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
243365008658	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
243365008659	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
243365008660	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
243365008661	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
243365008662	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
243365008663	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
243365008664	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365008665	active site
243365008666	phosphorylation site [posttranslational modification]
243365008667	intermolecular recognition site; other site
243365008668	dimerization interface [polypeptide binding]; other site
243365008669	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243365008670	helicase 45; Provisional; Region: PTZ00424
243365008671	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
243365008672	ATP binding site [chemical binding]; other site
243365008673	Mg++ binding site [ion binding]; other site
243365008674	motif III; other site
243365008675	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243365008676	nucleotide binding region [chemical binding]; other site
243365008677	ATP-binding site [chemical binding]; other site
243365008678	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
243365008679	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
243365008680	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
243365008681	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
243365008682	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
243365008683	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
243365008684	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
243365008685	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
243365008686	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365008687	dimer interface [polypeptide binding]; other site
243365008688	conserved gate region; other site
243365008689	putative PBP binding loops; other site
243365008690	ABC-ATPase subunit interface; other site
243365008691	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
243365008692	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365008693	dimer interface [polypeptide binding]; other site
243365008694	conserved gate region; other site
243365008695	putative PBP binding loops; other site
243365008696	ABC-ATPase subunit interface; other site
243365008697	metabolite-proton symporter; Region: 2A0106; TIGR00883
243365008698	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365008699	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365008700	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
243365008701	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
243365008702	gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516
243365008703	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
243365008704	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
243365008705	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
243365008706	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
243365008707	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
243365008708	putative NADH binding site [chemical binding]; other site
243365008709	putative active site [active]
243365008710	nudix motif; other site
243365008711	putative metal binding site [ion binding]; other site
243365008712	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
243365008713	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243365008714	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365008715	dimer interface [polypeptide binding]; other site
243365008716	putative CheW interface [polypeptide binding]; other site
243365008717	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
243365008718	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
243365008719	multifunctional aminopeptidase A; Provisional; Region: PRK00913
243365008720	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
243365008721	interface (dimer of trimers) [polypeptide binding]; other site
243365008722	Substrate-binding/catalytic site; other site
243365008723	Zn-binding sites [ion binding]; other site
243365008724	Predicted permeases [General function prediction only]; Region: COG0795
243365008725	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
243365008726	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
243365008727	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
243365008728	PII uridylyl-transferase; Provisional; Region: PRK03059
243365008729	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
243365008730	metal binding triad; other site
243365008731	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
243365008732	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243365008733	Zn2+ binding site [ion binding]; other site
243365008734	Mg2+ binding site [ion binding]; other site
243365008735	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
243365008736	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
243365008737	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
243365008738	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365008739	Coenzyme A binding pocket [chemical binding]; other site
243365008740	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
243365008741	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
243365008742	catalytic site [active]
243365008743	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
243365008744	putative active site [active]
243365008745	putative catalytic site [active]
243365008746	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
243365008747	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
243365008748	active site
243365008749	ParA-like protein; Provisional; Region: PHA02518
243365008750	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
243365008751	P-loop; other site
243365008752	Magnesium ion binding site [ion binding]; other site
243365008753	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
243365008754	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243365008755	motif II; other site
243365008756	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
243365008757	Uncharacterized conserved protein [Function unknown]; Region: COG1739
243365008758	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
243365008759	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
243365008760	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
243365008761	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
243365008762	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
243365008763	intracellular septation protein A; Reviewed; Region: PRK00259
243365008764	YciI-like protein; Reviewed; Region: PRK11370
243365008765	BolA-like protein; Region: BolA; pfam01722
243365008766	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
243365008767	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
243365008768	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
243365008769	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
243365008770	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
243365008771	chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214
243365008772	GH18 domain of Chitinase D (ChiD).  ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins.  The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871
243365008773	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
243365008774	putative active site [active]
243365008775	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
243365008776	heme-binding site [chemical binding]; other site
243365008777	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
243365008778	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
243365008779	catalytic residues [active]
243365008780	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
243365008781	transcriptional regulator; Provisional; Region: PRK10632
243365008782	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365008783	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
243365008784	putative effector binding pocket; other site
243365008785	dimerization interface [polypeptide binding]; other site
243365008786	poly-beta-1,6-N-acetyl-D-glucosamine biosynthesis protein PgaD; Region: PGA_PgaD; TIGR03940
243365008787	N-glycosyltransferase; Provisional; Region: PRK11204
243365008788	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
243365008789	DXD motif; other site
243365008790	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
243365008791	N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964
243365008792	putative active site [active]
243365008793	putative metal binding site [ion binding]; other site
243365008794	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
243365008795	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
243365008796	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
243365008797	putative active site [active]
243365008798	putative dimer interface [polypeptide binding]; other site
243365008799	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
243365008800	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
243365008801	ligand binding site [chemical binding]; other site
243365008802	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the bacterial CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain.  Members of CAP_ED, include CAP...; Region: CBS_pair_CAP-ED_DUF294_assoc_bac; cd04589
243365008803	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
243365008804	metal binding triad; other site
243365008805	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
243365008806	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
243365008807	active site
243365008808	catalytic site [active]
243365008809	substrate binding site [chemical binding]; other site
243365008810	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
243365008811	substrate binding pocket [chemical binding]; other site
243365008812	membrane-bound complex binding site; other site
243365008813	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
243365008814	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365008815	Coenzyme A binding pocket [chemical binding]; other site
243365008816	PAS fold; Region: PAS_4; pfam08448
243365008817	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365008818	putative active site [active]
243365008819	heme pocket [chemical binding]; other site
243365008820	PAS fold; Region: PAS_3; pfam08447
243365008821	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
243365008822	PAS fold; Region: PAS_3; pfam08447
243365008823	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
243365008824	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365008825	cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359
243365008826	putative active site [active]
243365008827	heme pocket [chemical binding]; other site
243365008828	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365008829	putative active site [active]
243365008830	heme pocket [chemical binding]; other site
243365008831	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365008832	putative active site [active]
243365008833	heme pocket [chemical binding]; other site
243365008834	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365008835	metal binding site [ion binding]; metal-binding site
243365008836	active site
243365008837	I-site; other site
243365008838	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243365008839	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
243365008840	Transcriptional regulators [Transcription]; Region: PurR; COG1609
243365008841	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
243365008842	DNA binding site [nucleotide binding]
243365008843	domain linker motif; other site
243365008844	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
243365008845	putative dimerization interface [polypeptide binding]; other site
243365008846	putative ligand binding site [chemical binding]; other site
243365008847	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
243365008848	AAA domain; Region: AAA_33; pfam13671
243365008849	ATP-binding site [chemical binding]; other site
243365008850	Gluconate-6-phosphate binding site [chemical binding]; other site
243365008851	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365008852	D-galactonate transporter; Region: 2A0114; TIGR00893
243365008853	putative substrate translocation pore; other site
243365008854	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
243365008855	active site
243365008856	NTP binding site [chemical binding]; other site
243365008857	metal binding triad [ion binding]; metal-binding site
243365008858	antibiotic binding site [chemical binding]; other site
243365008859	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
243365008860	nudix motif; other site
243365008861	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
243365008862	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365008863	active site
243365008864	phosphorylation site [posttranslational modification]
243365008865	intermolecular recognition site; other site
243365008866	dimerization interface [polypeptide binding]; other site
243365008867	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
243365008868	DNA binding residues [nucleotide binding]
243365008869	dimerization interface [polypeptide binding]; other site
243365008870	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
243365008871	Mechanosensitive ion channel; Region: MS_channel; pfam00924
243365008872	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
243365008873	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
243365008874	Walker A/P-loop; other site
243365008875	ATP binding site [chemical binding]; other site
243365008876	Q-loop/lid; other site
243365008877	ABC transporter signature motif; other site
243365008878	Walker B; other site
243365008879	D-loop; other site
243365008880	H-loop/switch region; other site
243365008881	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
243365008882	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
243365008883	FtsX-like permease family; Region: FtsX; pfam02687
243365008884	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
243365008885	NlpC/P60 family; Region: NLPC_P60; pfam00877
243365008886	ABC1 family; Region: ABC1; cl17513
243365008887	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
243365008888	cystine transporter subunit; Provisional; Region: PRK11260
243365008889	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243365008890	substrate binding pocket [chemical binding]; other site
243365008891	membrane-bound complex binding site; other site
243365008892	hinge residues; other site
243365008893	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811
243365008894	Putative zinc-finger; Region: zf-HC2; pfam13490
243365008895	RNA polymerase sigma-70 factor, TIGR02943 family; Region: Sig70_famx1
243365008896	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
243365008897	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
243365008898	DNA repair protein RadA; Provisional; Region: PRK11823
243365008899	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
243365008900	Walker A motif/ATP binding site; other site
243365008901	ATP binding site [chemical binding]; other site
243365008902	Walker B motif; other site
243365008903	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
243365008904	short chain dehydrogenase; Provisional; Region: PRK08703
243365008905	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243365008906	NAD(P) binding site [chemical binding]; other site
243365008907	active site
243365008908	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
243365008909	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
243365008910	active site lid residues [active]
243365008911	substrate binding pocket [chemical binding]; other site
243365008912	catalytic residues [active]
243365008913	substrate-Mg2+ binding site; other site
243365008914	aspartate-rich region 1; other site
243365008915	aspartate-rich region 2; other site
243365008916	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
243365008917	active site lid residues [active]
243365008918	substrate binding pocket [chemical binding]; other site
243365008919	catalytic residues [active]
243365008920	substrate-Mg2+ binding site; other site
243365008921	aspartate-rich region 1; other site
243365008922	aspartate-rich region 2; other site
243365008923	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
243365008924	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
243365008925	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243365008926	Walker A/P-loop; other site
243365008927	ATP binding site [chemical binding]; other site
243365008928	Q-loop/lid; other site
243365008929	ABC transporter signature motif; other site
243365008930	Walker B; other site
243365008931	D-loop; other site
243365008932	H-loop/switch region; other site
243365008933	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365008934	dimer interface [polypeptide binding]; other site
243365008935	conserved gate region; other site
243365008936	putative PBP binding loops; other site
243365008937	ABC-ATPase subunit interface; other site
243365008938	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243365008939	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243365008940	substrate binding pocket [chemical binding]; other site
243365008941	membrane-bound complex binding site; other site
243365008942	hinge residues; other site
243365008943	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
243365008944	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
243365008945	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
243365008946	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
243365008947	ligand binding site [chemical binding]; other site
243365008948	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
243365008949	non-specific DNA interactions [nucleotide binding]; other site
243365008950	DNA binding site [nucleotide binding]
243365008951	sequence specific DNA binding site [nucleotide binding]; other site
243365008952	putative cAMP binding site [chemical binding]; other site
243365008953	flagellar motor protein MotB; Validated; Region: motB; PRK09041
243365008954	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
243365008955	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
243365008956	ligand binding site [chemical binding]; other site
243365008957	flagellar motor protein MotA; Provisional; Region: PRK12482
243365008958	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
243365008959	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
243365008960	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
243365008961	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
243365008962	DNA binding residues [nucleotide binding]
243365008963	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
243365008964	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
243365008965	Flagellar protein FliS; Region: FliS; cl00654
243365008966	Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345
243365008967	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
243365008968	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
243365008969	flagellum-specific ATP synthase; Validated; Region: fliI; PRK07196
243365008970	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
243365008971	Walker A motif; other site
243365008972	ATP binding site [chemical binding]; other site
243365008973	Walker B motif; other site
243365008974	flagellar assembly protein H; Provisional; Region: fliH; PRK13386
243365008975	Flagellar assembly protein FliH; Region: FliH; pfam02108
243365008976	flagellar motor switch protein G; Reviewed; Region: fliG; PRK07194
243365008977	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
243365008978	FliG C-terminal domain; Region: FliG_C; pfam01706
243365008979	flagellar MS-ring protein; Reviewed; Region: fliF; PRK07193
243365008980	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
243365008981	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
243365008982	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
243365008983	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
243365008984	flagellar motor switch protein FliN; Region: fliN; TIGR02480
243365008985	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
243365008986	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
243365008987	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
243365008988	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
243365008989	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
243365008990	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
243365008991	FHIPEP family; Region: FHIPEP; pfam00771
243365008992	BetR domain; Region: BetR; pfam08667
243365008993	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
243365008994	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365008995	active site
243365008996	phosphorylation site [posttranslational modification]
243365008997	intermolecular recognition site; other site
243365008998	dimerization interface [polypeptide binding]; other site
243365008999	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243365009000	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243365009001	dimer interface [polypeptide binding]; other site
243365009002	phosphorylation site [posttranslational modification]
243365009003	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365009004	ATP binding site [chemical binding]; other site
243365009005	Mg2+ binding site [ion binding]; other site
243365009006	G-X-G motif; other site
243365009007	Response regulator receiver domain; Region: Response_reg; pfam00072
243365009008	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365009009	active site
243365009010	phosphorylation site [posttranslational modification]
243365009011	intermolecular recognition site; other site
243365009012	dimerization interface [polypeptide binding]; other site
243365009013	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
243365009014	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
243365009015	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
243365009016	Serine carboxypeptidase; Region: Peptidase_S10; pfam00450
243365009017	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
243365009018	CoA-transferase family III; Region: CoA_transf_3; pfam02515
243365009019	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365009020	Major Facilitator Superfamily; Region: MFS_1; pfam07690
243365009021	putative substrate translocation pore; other site
243365009022	D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417
243365009023	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
243365009024	DNA binding site [nucleotide binding]
243365009025	domain linker motif; other site
243365009026	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
243365009027	dimerization interface [polypeptide binding]; other site
243365009028	ligand binding site [chemical binding]; other site
243365009029	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
243365009030	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
243365009031	ligand binding site [chemical binding]; other site
243365009032	dimerization interface [polypeptide binding]; other site
243365009033	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
243365009034	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
243365009035	TM-ABC transporter signature motif; other site
243365009036	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
243365009037	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
243365009038	Walker A/P-loop; other site
243365009039	ATP binding site [chemical binding]; other site
243365009040	Q-loop/lid; other site
243365009041	ABC transporter signature motif; other site
243365009042	Walker B; other site
243365009043	D-loop; other site
243365009044	H-loop/switch region; other site
243365009045	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
243365009046	D-ribose pyranase; Provisional; Region: PRK11797
243365009047	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
243365009048	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
243365009049	substrate binding site [chemical binding]; other site
243365009050	dimer interface [polypeptide binding]; other site
243365009051	ATP binding site [chemical binding]; other site
243365009052	MgtC family; Region: MgtC; pfam02308
243365009053	Predicted ATPase [General function prediction only]; Region: COG1485
243365009054	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243365009055	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243365009056	substrate binding pocket [chemical binding]; other site
243365009057	membrane-bound complex binding site; other site
243365009058	hinge residues; other site
243365009059	glutathione S-transferase; Provisional; Region: PRK15113
243365009060	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
243365009061	C-terminal domain interface [polypeptide binding]; other site
243365009062	GSH binding site (G-site) [chemical binding]; other site
243365009063	dimer interface [polypeptide binding]; other site
243365009064	C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195
243365009065	putative substrate binding pocket (H-site) [chemical binding]; other site
243365009066	N-terminal domain interface [polypeptide binding]; other site
243365009067	cysteine synthase B; Region: cysM; TIGR01138
243365009068	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
243365009069	dimer interface [polypeptide binding]; other site
243365009070	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365009071	catalytic residue [active]
243365009072	glycolate transporter; Provisional; Region: PRK09695
243365009073	L-lactate permease; Region: Lactate_perm; cl00701
243365009074	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
243365009075	FAD binding domain; Region: FAD_binding_4; pfam01565
243365009076	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
243365009077	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
243365009078	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
243365009079	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
243365009080	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
243365009081	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
243365009082	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
243365009083	Cysteine-rich domain; Region: CCG; pfam02754
243365009084	Cysteine-rich domain; Region: CCG; pfam02754
243365009085	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
243365009086	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
243365009087	amidase catalytic site [active]
243365009088	Zn binding residues [ion binding]; other site
243365009089	substrate binding site [chemical binding]; other site
243365009090	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
243365009091	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
243365009092	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365009093	active site
243365009094	phosphorylation site [posttranslational modification]
243365009095	intermolecular recognition site; other site
243365009096	dimerization interface [polypeptide binding]; other site
243365009097	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
243365009098	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
243365009099	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
243365009100	DNA-binding site [nucleotide binding]; DNA binding site
243365009101	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
243365009102	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
243365009103	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
243365009104	NADP binding site [chemical binding]; other site
243365009105	homopentamer interface [polypeptide binding]; other site
243365009106	substrate binding site [chemical binding]; other site
243365009107	active site
243365009108	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
243365009109	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
243365009110	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
243365009111	putative ribose interaction site [chemical binding]; other site
243365009112	putative ADP binding site [chemical binding]; other site
243365009113	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
243365009114	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
243365009115	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
243365009116	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
243365009117	active site
243365009118	dimer interface [polypeptide binding]; other site
243365009119	tetratricopeptide repeat protein; Provisional; Region: PRK11788
243365009120	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
243365009121	binding surface
243365009122	TPR motif; other site
243365009123	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
243365009124	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
243365009125	IHF dimer interface [polypeptide binding]; other site
243365009126	IHF - DNA interface [nucleotide binding]; other site
243365009127	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
243365009128	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
243365009129	RNA binding site [nucleotide binding]; other site
243365009130	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
243365009131	RNA binding site [nucleotide binding]; other site
243365009132	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
243365009133	RNA binding site [nucleotide binding]; other site
243365009134	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
243365009135	RNA binding site [nucleotide binding]; other site
243365009136	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
243365009137	RNA binding site [nucleotide binding]; other site
243365009138	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
243365009139	RNA binding site [nucleotide binding]; other site
243365009140	cytidylate kinase; Provisional; Region: cmk; PRK00023
243365009141	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
243365009142	CMP-binding site; other site
243365009143	The sites determining sugar specificity; other site
243365009144	3-phosphoshikimate 1-carboxyvinyltransferase; Region: PLN02338
243365009145	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
243365009146	hinge; other site
243365009147	active site
243365009148	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
243365009149	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
243365009150	Transcriptional regulators [Transcription]; Region: PurR; COG1609
243365009151	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
243365009152	DNA binding site [nucleotide binding]
243365009153	domain linker motif; other site
243365009154	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_4; cd06280
243365009155	putative dimerization interface [polypeptide binding]; other site
243365009156	putative ligand binding site [chemical binding]; other site
243365009157	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
243365009158	active site
243365009159	phosphorylation site [posttranslational modification]
243365009160	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
243365009161	dimerization domain swap beta strand [polypeptide binding]; other site
243365009162	regulatory protein interface [polypeptide binding]; other site
243365009163	active site
243365009164	regulatory phosphorylation site [posttranslational modification]; other site
243365009165	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
243365009166	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
243365009167	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
243365009168	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
243365009169	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
243365009170	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
243365009171	putative substrate binding site [chemical binding]; other site
243365009172	putative ATP binding site [chemical binding]; other site
243365009173	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
243365009174	active site
243365009175	P-loop; other site
243365009176	phosphorylation site [posttranslational modification]
243365009177	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
243365009178	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
243365009179	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
243365009180	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
243365009181	Cytochrome c; Region: Cytochrom_C; pfam00034
243365009182	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
243365009183	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
243365009184	C-terminal domain interface [polypeptide binding]; other site
243365009185	GSH binding site (G-site) [chemical binding]; other site
243365009186	dimer interface [polypeptide binding]; other site
243365009187	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
243365009188	N-terminal domain interface [polypeptide binding]; other site
243365009189	dimer interface [polypeptide binding]; other site
243365009190	putative substrate binding pocket (H-site) [chemical binding]; other site
243365009191	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
243365009192	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
243365009193	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365009194	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365009195	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
243365009196	dimerization interface [polypeptide binding]; other site
243365009197	enoyl-CoA hydratase; Provisional; Region: PRK09076
243365009198	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
243365009199	substrate binding site [chemical binding]; other site
243365009200	oxyanion hole (OAH) forming residues; other site
243365009201	trimer interface [polypeptide binding]; other site
243365009202	Family description; Region: DsbD_2; pfam13386
243365009203	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
243365009204	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
243365009205	metal binding site [ion binding]; metal-binding site
243365009206	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
243365009207	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
243365009208	ABC-ATPase subunit  interface; other site
243365009209	dimer interface [polypeptide binding]; other site
243365009210	putative PBP binding regions; other site
243365009211	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
243365009212	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
243365009213	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
243365009214	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
243365009215	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
243365009216	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
243365009217	metal binding site 2 [ion binding]; metal-binding site
243365009218	putative DNA binding helix; other site
243365009219	metal binding site 1 [ion binding]; metal-binding site
243365009220	dimer interface [polypeptide binding]; other site
243365009221	structural Zn2+ binding site [ion binding]; other site
243365009222	Cytochrome C' Region: Cytochrom_C_2; pfam01322
243365009223	Cytochrome C' Region: Cytochrom_C_2; pfam01322
243365009224	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
243365009225	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
243365009226	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
243365009227	active site
243365009228	HIGH motif; other site
243365009229	dimer interface [polypeptide binding]; other site
243365009230	KMSKS motif; other site
243365009231	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
243365009232	RNA binding surface [nucleotide binding]; other site
243365009233	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
243365009234	Protein of unknown function (DUF3443); Region: DUF3443; pfam11925
243365009235	Protein of unknown function (DUF2844); Region: DUF2844; pfam11005
243365009236	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
243365009237	hypothetical protein; Reviewed; Region: PRK00024
243365009238	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
243365009239	MPN+ (JAMM) motif; other site
243365009240	Zinc-binding site [ion binding]; other site
243365009241	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
243365009242	Flavoprotein; Region: Flavoprotein; pfam02441
243365009243	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
243365009244	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
243365009245	trimer interface [polypeptide binding]; other site
243365009246	active site
243365009247	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365009248	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365009249	metal binding site [ion binding]; metal-binding site
243365009250	active site
243365009251	I-site; other site
243365009252	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
243365009253	NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530
243365009254	putative active site [active]
243365009255	putative metal binding site [ion binding]; other site
243365009256	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
243365009257	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
243365009258	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
243365009259	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
243365009260	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243365009261	substrate binding pocket [chemical binding]; other site
243365009262	membrane-bound complex binding site; other site
243365009263	hinge residues; other site
243365009264	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
243365009265	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365009266	dimer interface [polypeptide binding]; other site
243365009267	conserved gate region; other site
243365009268	putative PBP binding loops; other site
243365009269	ABC-ATPase subunit interface; other site
243365009270	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365009271	dimer interface [polypeptide binding]; other site
243365009272	conserved gate region; other site
243365009273	putative PBP binding loops; other site
243365009274	ABC-ATPase subunit interface; other site
243365009275	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
243365009276	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
243365009277	conserved cys residue [active]
243365009278	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
243365009279	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
243365009280	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
243365009281	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365009282	putative active site [active]
243365009283	heme pocket [chemical binding]; other site
243365009284	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243365009285	dimer interface [polypeptide binding]; other site
243365009286	phosphorylation site [posttranslational modification]
243365009287	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365009288	ATP binding site [chemical binding]; other site
243365009289	Mg2+ binding site [ion binding]; other site
243365009290	G-X-G motif; other site
243365009291	phosphoglycolate phosphatase; Provisional; Region: PRK13222
243365009292	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243365009293	motif II; other site
243365009294	threonine dehydratase; Reviewed; Region: PRK09224
243365009295	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
243365009296	tetramer interface [polypeptide binding]; other site
243365009297	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365009298	catalytic residue [active]
243365009299	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
243365009300	putative Ile/Val binding site [chemical binding]; other site
243365009301	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
243365009302	putative Ile/Val binding site [chemical binding]; other site
243365009303	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
243365009304	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
243365009305	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
243365009306	Protein of unknown function (DUF493); Region: DUF493; pfam04359
243365009307	lipoate-protein ligase B; Provisional; Region: PRK14342
243365009308	lipoyl synthase; Provisional; Region: PRK05481
243365009309	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243365009310	FeS/SAM binding site; other site
243365009311	magnesium-transporting ATPase; Provisional; Region: PRK15122
243365009312	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
243365009313	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
243365009314	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
243365009315	Soluble P-type ATPase [General function prediction only]; Region: COG4087
243365009316	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
243365009317	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
243365009318	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
243365009319	PYR/PP interface [polypeptide binding]; other site
243365009320	dimer interface [polypeptide binding]; other site
243365009321	TPP binding site [chemical binding]; other site
243365009322	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
243365009323	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
243365009324	TPP-binding site [chemical binding]; other site
243365009325	dimer interface [polypeptide binding]; other site
243365009326	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
243365009327	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
243365009328	hydroxyglutarate oxidase; Provisional; Region: PRK11728
243365009329	Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636
243365009330	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
243365009331	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
243365009332	trimer interface [polypeptide binding]; other site
243365009333	eyelet of channel; other site
243365009334	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243365009335	dimer interface [polypeptide binding]; other site
243365009336	phosphorylation site [posttranslational modification]
243365009337	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365009338	ATP binding site [chemical binding]; other site
243365009339	Mg2+ binding site [ion binding]; other site
243365009340	G-X-G motif; other site
243365009341	osmolarity response regulator; Provisional; Region: ompR; PRK09468
243365009342	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365009343	active site
243365009344	phosphorylation site [posttranslational modification]
243365009345	intermolecular recognition site; other site
243365009346	dimerization interface [polypeptide binding]; other site
243365009347	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
243365009348	DNA binding site [nucleotide binding]
243365009349	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
243365009350	heat shock protein HtpX; Provisional; Region: PRK05457
243365009351	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
243365009352	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365009353	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
243365009354	dimerization interface [polypeptide binding]; other site
243365009355	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
243365009356	Type II transport protein GspH; Region: GspH; pfam12019
243365009357	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
243365009358	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
243365009359	Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726
243365009360	PilX N-terminal; Region: PilX_N; pfam14341
243365009361	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
243365009362	legume lectins; Region: lectin_L-type; cl14058
243365009363	homotetramer interaction site [polypeptide binding]; other site
243365009364	carbohydrate binding site [chemical binding]; other site
243365009365	metal binding site [ion binding]; metal-binding site
243365009366	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
243365009367	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
243365009368	Acyl CoA binding protein; Region: ACBP; pfam00887
243365009369	acyl-CoA binding pocket [chemical binding]; other site
243365009370	CoA binding site [chemical binding]; other site
243365009371	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
243365009372	dimerization domain [polypeptide binding]; other site
243365009373	dimer interface [polypeptide binding]; other site
243365009374	catalytic residues [active]
243365009375	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608
243365009376	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
243365009377	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
243365009378	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
243365009379	proline aminopeptidase P II; Provisional; Region: PRK10879
243365009380	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
243365009381	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
243365009382	active site
243365009383	hypothetical protein; Validated; Region: PRK00110
243365009384	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
243365009385	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
243365009386	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
243365009387	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
243365009388	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
243365009389	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
243365009390	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
243365009391	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
243365009392	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
243365009393	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
243365009394	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
243365009395	Flagellar FliJ protein; Region: FliJ; pfam02050
243365009396	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
243365009397	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
243365009398	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
243365009399	Walker A motif/ATP binding site; other site
243365009400	Walker B motif; other site
243365009401	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
243365009402	FliG C-terminal domain; Region: FliG_C; pfam01706
243365009403	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
243365009404	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
243365009405	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
243365009406	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
243365009407	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
243365009408	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365009409	active site
243365009410	phosphorylation site [posttranslational modification]
243365009411	intermolecular recognition site; other site
243365009412	dimerization interface [polypeptide binding]; other site
243365009413	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243365009414	Walker A motif; other site
243365009415	ATP binding site [chemical binding]; other site
243365009416	Walker B motif; other site
243365009417	arginine finger; other site
243365009418	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
243365009419	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
243365009420	CheB methylesterase; Region: CheB_methylest; pfam01339
243365009421	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
243365009422	Low molecular weight phosphatase family; Region: LMWPc; cd00115
243365009423	Bulb-type mannose-specific lectin; Region: B_lectin; smart00108
243365009424	Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028
243365009425	dimerization interface [polypeptide binding]; other site
243365009426	mannose binding site [chemical binding]; other site
243365009427	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365009428	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365009429	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
243365009430	putative dimerization interface [polypeptide binding]; other site
243365009431	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
243365009432	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
243365009433	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
243365009434	Protein of unknown function (DUF917); Region: DUF917; pfam06032
243365009435	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
243365009436	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243365009437	Walker A motif; other site
243365009438	ATP binding site [chemical binding]; other site
243365009439	Walker B motif; other site
243365009440	arginine finger; other site
243365009441	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
243365009442	excinuclease ABC subunit B; Provisional; Region: PRK05298
243365009443	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
243365009444	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
243365009445	ATP-binding site [chemical binding]; other site
243365009446	ATP binding site [chemical binding]; other site
243365009447	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
243365009448	nucleotide binding region [chemical binding]; other site
243365009449	ATP-binding site [chemical binding]; other site
243365009450	Ultra-violet resistance protein B; Region: UvrB; pfam12344
243365009451	UvrB/uvrC motif; Region: UVR; pfam02151
243365009452	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
243365009453	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
243365009454	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365009455	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365009456	The C-terminal substrate biniding domain of an uncharacterized LysR-like transcriptional regulator Pa0477 related to DntR, contains the type 2 periplasmic binding fold; Region: PBP2_Pa0477; cd08468
243365009457	putative substrate binding pocket [chemical binding]; other site
243365009458	dimerization interface [polypeptide binding]; other site
243365009459	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365009460	Coenzyme A binding pocket [chemical binding]; other site
243365009461	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
243365009462	substrate binding site [chemical binding]; other site
243365009463	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
243365009464	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
243365009465	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
243365009466	dimer interface [polypeptide binding]; other site
243365009467	putative metal binding site [ion binding]; other site
243365009468	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
243365009469	MarR family; Region: MarR; pfam01047
243365009470	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
243365009471	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
243365009472	Walker A/P-loop; other site
243365009473	ATP binding site [chemical binding]; other site
243365009474	Q-loop/lid; other site
243365009475	ABC transporter signature motif; other site
243365009476	Walker B; other site
243365009477	D-loop; other site
243365009478	H-loop/switch region; other site
243365009479	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365009480	dimer interface [polypeptide binding]; other site
243365009481	conserved gate region; other site
243365009482	putative PBP binding loops; other site
243365009483	ABC-ATPase subunit interface; other site
243365009484	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
243365009485	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
243365009486	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
243365009487	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
243365009488	Coenzyme A binding pocket [chemical binding]; other site
243365009489	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
243365009490	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
243365009491	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
243365009492	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
243365009493	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243365009494	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243365009495	substrate binding pocket [chemical binding]; other site
243365009496	membrane-bound complex binding site; other site
243365009497	hinge residues; other site
243365009498	MarR family; Region: MarR_2; cl17246
243365009499	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
243365009500	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
243365009501	Allophanate hydrolase subunit 2; Region: AHS2; cl00865
243365009502	Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800
243365009503	putative active site [active]
243365009504	Protein of unknown function (DUF969); Region: DUF969; pfam06149
243365009505	Predicted membrane protein [Function unknown]; Region: COG3817
243365009506	Protein of unknown function (DUF979); Region: DUF979; pfam06166
243365009507	Predicted membrane protein [Function unknown]; Region: COG3817
243365009508	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
243365009509	putative substrate binding pocket [chemical binding]; other site
243365009510	AC domain interface; other site
243365009511	catalytic triad [active]
243365009512	AB domain interface; other site
243365009513	interchain disulfide; other site
243365009514	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
243365009515	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
243365009516	Substrate binding site; other site
243365009517	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
243365009518	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
243365009519	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
243365009520	cofactor binding site; other site
243365009521	metal binding site [ion binding]; metal-binding site
243365009522	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
243365009523	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
243365009524	AsnC family; Region: AsnC_trans_reg; pfam01037
243365009525	Cysteine dioxygenase type I; Region: CDO_I; pfam05995
243365009526	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
243365009527	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
243365009528	substrate binding site [chemical binding]; other site
243365009529	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
243365009530	substrate binding site [chemical binding]; other site
243365009531	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
243365009532	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
243365009533	putative active site [active]
243365009534	putative metal binding site [ion binding]; other site
243365009535	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
243365009536	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
243365009537	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
243365009538	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
243365009539	Ligand Binding Site [chemical binding]; other site
243365009540	TilS substrate binding domain; Region: TilS; pfam09179
243365009541	TilS substrate C-terminal domain; Region: TilS_C; smart00977
243365009542	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
243365009543	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
243365009544	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
243365009545	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254
243365009546	FecR protein; Region: FecR; pfam04773
243365009547	CHASE2 domain; Region: CHASE2; pfam05226
243365009548	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
243365009549	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365009550	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365009551	metal binding site [ion binding]; metal-binding site
243365009552	active site
243365009553	I-site; other site
243365009554	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
243365009555	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
243365009556	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
243365009557	active site
243365009558	nucleophile elbow; other site
243365009559	AlkA N-terminal domain; Region: AlkA_N; cl05528
243365009560	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
243365009561	endonuclease III; Region: ENDO3c; smart00478
243365009562	minor groove reading motif; other site
243365009563	helix-hairpin-helix signature motif; other site
243365009564	substrate binding pocket [chemical binding]; other site
243365009565	active site
243365009566	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
243365009567	peptidase PmbA; Provisional; Region: PRK11040
243365009568	hypothetical protein; Provisional; Region: PRK05255
243365009569	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
243365009570	MPT binding site; other site
243365009571	trimer interface [polypeptide binding]; other site
243365009572	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
243365009573	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
243365009574	CoenzymeA binding site [chemical binding]; other site
243365009575	subunit interaction site [polypeptide binding]; other site
243365009576	PHB binding site; other site
243365009577	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243365009578	Zn2+ binding site [ion binding]; other site
243365009579	Mg2+ binding site [ion binding]; other site
243365009580	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
243365009581	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
243365009582	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
243365009583	putative binding surface; other site
243365009584	active site
243365009585	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243365009586	Zn2+ binding site [ion binding]; other site
243365009587	Mg2+ binding site [ion binding]; other site
243365009588	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
243365009589	DNA-binding site [nucleotide binding]; DNA binding site
243365009590	RNA-binding motif; other site
243365009591	Protein of unknown function (DUF1415); Region: DUF1415; pfam07209
243365009592	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
243365009593	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
243365009594	putative acyl-acceptor binding pocket; other site
243365009595	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
243365009596	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
243365009597	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
243365009598	catalytic core [active]
243365009599	methionine sulfoxide reductase B; Provisional; Region: PRK00222
243365009600	SelR domain; Region: SelR; pfam01641
243365009601	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
243365009602	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
243365009603	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
243365009604	Soluble P-type ATPase [General function prediction only]; Region: COG4087
243365009605	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
243365009606	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
243365009607	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
243365009608	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
243365009609	NADH dehydrogenase subunit L; Provisional; Region: PRK08168
243365009610	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
243365009611	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365009612	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365009613	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
243365009614	dimerization interface [polypeptide binding]; other site
243365009615	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243365009616	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
243365009617	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
243365009618	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
243365009619	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
243365009620	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
243365009621	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365009622	S-adenosylmethionine binding site [chemical binding]; other site
243365009623	classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350
243365009624	putative NAD(P) binding site [chemical binding]; other site
243365009625	active site
243365009626	SnoaL-like domain; Region: SnoaL_2; pfam12680
243365009627	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
243365009628	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
243365009629	Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040
243365009630	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
243365009631	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
243365009632	oligomerisation interface [polypeptide binding]; other site
243365009633	mobile loop; other site
243365009634	roof hairpin; other site
243365009635	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
243365009636	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
243365009637	ring oligomerisation interface [polypeptide binding]; other site
243365009638	ATP/Mg binding site [chemical binding]; other site
243365009639	stacking interactions; other site
243365009640	hinge regions; other site
243365009641	BON domain; Region: BON; pfam04972
243365009642	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg7; cd04786
243365009643	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
243365009644	DNA binding residues [nucleotide binding]
243365009645	putative dimer interface [polypeptide binding]; other site
243365009646	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
243365009647	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
243365009648	potential catalytic triad [active]
243365009649	conserved cys residue [active]
243365009650	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
243365009651	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
243365009652	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365009653	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365009654	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
243365009655	substrate binding pocket [chemical binding]; other site
243365009656	dimerization interface [polypeptide binding]; other site
243365009657	LysE type translocator; Region: LysE; cl00565
243365009658	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
243365009659	putative deacylase active site [active]
243365009660	Major Facilitator Superfamily; Region: MFS_1; pfam07690
243365009661	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365009662	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
243365009663	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243365009664	active site
243365009665	motif I; other site
243365009666	motif II; other site
243365009667	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243365009668	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
243365009669	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
243365009670	Divalent cation transporter; Region: MgtE; pfam01769
243365009671	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
243365009672	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365009673	active site
243365009674	phosphorylation site [posttranslational modification]
243365009675	intermolecular recognition site; other site
243365009676	dimerization interface [polypeptide binding]; other site
243365009677	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243365009678	Zn2+ binding site [ion binding]; other site
243365009679	Mg2+ binding site [ion binding]; other site
243365009680	PAS fold; Region: PAS_4; pfam08448
243365009681	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365009682	putative active site [active]
243365009683	heme pocket [chemical binding]; other site
243365009684	PAS fold; Region: PAS_3; pfam08447
243365009685	PAS fold; Region: PAS_4; pfam08448
243365009686	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365009687	putative active site [active]
243365009688	heme pocket [chemical binding]; other site
243365009689	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365009690	PAS domain; Region: PAS_9; pfam13426
243365009691	putative active site [active]
243365009692	heme pocket [chemical binding]; other site
243365009693	PAS domain S-box; Region: sensory_box; TIGR00229
243365009694	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365009695	putative active site [active]
243365009696	heme pocket [chemical binding]; other site
243365009697	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365009698	PAS domain; Region: PAS_9; pfam13426
243365009699	putative active site [active]
243365009700	heme pocket [chemical binding]; other site
243365009701	PAS domain; Region: PAS_9; pfam13426
243365009702	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365009703	putative active site [active]
243365009704	heme pocket [chemical binding]; other site
243365009705	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243365009706	dimer interface [polypeptide binding]; other site
243365009707	phosphorylation site [posttranslational modification]
243365009708	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365009709	ATP binding site [chemical binding]; other site
243365009710	Mg2+ binding site [ion binding]; other site
243365009711	G-X-G motif; other site
243365009712	Response regulator receiver domain; Region: Response_reg; pfam00072
243365009713	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365009714	active site
243365009715	phosphorylation site [posttranslational modification]
243365009716	intermolecular recognition site; other site
243365009717	dimerization interface [polypeptide binding]; other site
243365009718	FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198
243365009719	putative binding surface; other site
243365009720	active site
243365009721	ornithine cyclodeaminase; Validated; Region: PRK06823
243365009722	ectoine utilization protein EutC; Validated; Region: PRK08291
243365009723	hypothetical protein; Provisional; Region: PRK06815
243365009724	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
243365009725	tetramer interface [polypeptide binding]; other site
243365009726	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365009727	catalytic residue [active]
243365009728	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
243365009729	YheO-like PAS domain; Region: PAS_6; pfam08348
243365009730	HTH domain; Region: HTH_22; pfam13309
243365009731	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365009732	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365009733	metal binding site [ion binding]; metal-binding site
243365009734	active site
243365009735	I-site; other site
243365009736	Pirin-related protein [General function prediction only]; Region: COG1741
243365009737	Pirin; Region: Pirin; pfam02678
243365009738	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365009739	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365009740	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
243365009741	putative effector binding pocket; other site
243365009742	dimerization interface [polypeptide binding]; other site
243365009743	Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453
243365009744	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
243365009745	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
243365009746	PAS fold; Region: PAS_4; pfam08448
243365009747	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
243365009748	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
243365009749	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365009750	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365009751	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
243365009752	dimerization interface [polypeptide binding]; other site
243365009753	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
243365009754	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
243365009755	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365009756	PAS domain; Region: PAS_9; pfam13426
243365009757	putative active site [active]
243365009758	heme pocket [chemical binding]; other site
243365009759	PAS domain S-box; Region: sensory_box; TIGR00229
243365009760	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365009761	putative active site [active]
243365009762	heme pocket [chemical binding]; other site
243365009763	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
243365009764	Histidine kinase; Region: HisKA_2; pfam07568
243365009765	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365009766	ATP binding site [chemical binding]; other site
243365009767	Mg2+ binding site [ion binding]; other site
243365009768	G-X-G motif; other site
243365009769	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
243365009770	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365009771	active site
243365009772	phosphorylation site [posttranslational modification]
243365009773	intermolecular recognition site; other site
243365009774	dimerization interface [polypeptide binding]; other site
243365009775	PAS domain S-box; Region: sensory_box; TIGR00229
243365009776	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365009777	putative active site [active]
243365009778	heme pocket [chemical binding]; other site
243365009779	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365009780	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365009781	metal binding site [ion binding]; metal-binding site
243365009782	active site
243365009783	I-site; other site
243365009784	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243365009785	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
243365009786	Common central domain of tyrosinase; Region: Tyrosinase; pfam00264
243365009787	Polyphenol oxidase middle domain; Region: PPO1_DWL; pfam12142
243365009788	Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948
243365009789	nitrobindin heme-binding domain; Region: nitrobindin; cl10502
243365009790	Ferritin-like; Region: Ferritin-like; pfam12902
243365009791	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
243365009792	violacein biosynthesis enzyme VioE; Region: violacein_E; TIGR03650
243365009793	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
243365009794	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
243365009795	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
243365009796	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
243365009797	Ferritin-like; Region: Ferritin-like; pfam12902
243365009798	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
243365009799	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
243365009800	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
243365009801	Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078
243365009802	putative catalytic site [active]
243365009803	metal binding site A [ion binding]; metal-binding site
243365009804	phosphate binding site [ion binding]; other site
243365009805	metal binding site C [ion binding]; metal-binding site
243365009806	metal binding site B [ion binding]; metal-binding site
243365009807	Uncharacterized conserved protein [Function unknown]; Region: COG2353
243365009808	YceI-like domain; Region: YceI; smart00867
243365009809	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
243365009810	Protein of unknown function, DUF485; Region: DUF485; pfam04341
243365009811	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
243365009812	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
243365009813	Na binding site [ion binding]; other site
243365009814	acetyl-CoA synthetase; Provisional; Region: PRK00174
243365009815	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
243365009816	active site
243365009817	CoA binding site [chemical binding]; other site
243365009818	acyl-activating enzyme (AAE) consensus motif; other site
243365009819	AMP binding site [chemical binding]; other site
243365009820	acetate binding site [chemical binding]; other site
243365009821	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
243365009822	Methyltransferase domain; Region: Methyltransf_31; pfam13847
243365009823	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365009824	S-adenosylmethionine binding site [chemical binding]; other site
243365009825	Vibrio chemotaxis protein N terminus; Region: MCP_N; pfam05581
243365009826	Cache domain; Region: Cache_1; pfam02743
243365009827	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243365009828	dimerization interface [polypeptide binding]; other site
243365009829	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243365009830	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365009831	dimer interface [polypeptide binding]; other site
243365009832	putative CheW interface [polypeptide binding]; other site
243365009833	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
243365009834	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
243365009835	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365009836	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365009837	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
243365009838	dimerization interface [polypeptide binding]; other site
243365009839	Ketopantoate hydroxymethyltransferase; Region: Pantoate_transf; pfam02548
243365009840	oligomerization interface [polypeptide binding]; other site
243365009841	active site
243365009842	metal binding site [ion binding]; metal-binding site
243365009843	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365009844	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365009845	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
243365009846	putative dimerization interface [polypeptide binding]; other site
243365009847	ferredoxin; Provisional; Region: PRK08764
243365009848	Putative Fe-S cluster; Region: FeS; pfam04060
243365009849	4Fe-4S binding domain; Region: Fer4; pfam00037
243365009850	endonuclease III; Provisional; Region: PRK10702
243365009851	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
243365009852	minor groove reading motif; other site
243365009853	helix-hairpin-helix signature motif; other site
243365009854	substrate binding pocket [chemical binding]; other site
243365009855	active site
243365009856	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
243365009857	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
243365009858	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
243365009859	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
243365009860	protein binding site [polypeptide binding]; other site
243365009861	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
243365009862	protein binding site [polypeptide binding]; other site
243365009863	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
243365009864	amino acid transporter; Region: 2A0306; TIGR00909
243365009865	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
243365009866	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
243365009867	trimer interface; other site
243365009868	sugar binding site [chemical binding]; other site
243365009869	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
243365009870	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
243365009871	Ca binding site [ion binding]; other site
243365009872	active site
243365009873	catalytic site [active]
243365009874	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
243365009875	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
243365009876	active site turn [active]
243365009877	phosphorylation site [posttranslational modification]
243365009878	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
243365009879	AIPR protein; Region: AIPR; pfam10592
243365009880	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
243365009881	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
243365009882	DNA-binding site [nucleotide binding]; DNA binding site
243365009883	UTRA domain; Region: UTRA; pfam07702
243365009884	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365009885	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365009886	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
243365009887	putative effector binding pocket; other site
243365009888	dimerization interface [polypeptide binding]; other site
243365009889	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
243365009890	malate synthase A; Region: malate_syn_A; TIGR01344
243365009891	active site
243365009892	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
243365009893	putative glutathione S-transferase; Provisional; Region: PRK10357
243365009894	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
243365009895	putative C-terminal domain interface [polypeptide binding]; other site
243365009896	putative GSH binding site (G-site) [chemical binding]; other site
243365009897	putative dimer interface [polypeptide binding]; other site
243365009898	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
243365009899	dimer interface [polypeptide binding]; other site
243365009900	N-terminal domain interface [polypeptide binding]; other site
243365009901	putative substrate binding pocket (H-site) [chemical binding]; other site
243365009902	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
243365009903	Biofilm formation and stress response factor; Region: BsmA; pfam10014
243365009904	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243365009905	Protein of unknown function (DUF465); Region: DUF465; cl01070
243365009906	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
243365009907	HflK protein; Region: hflK; TIGR01933
243365009908	HflC protein; Region: hflC; TIGR01932
243365009909	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
243365009910	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
243365009911	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
243365009912	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
243365009913	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
243365009914	aromatic chitin/cellulose binding site residues [chemical binding]; other site
243365009915	Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325
243365009916	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
243365009917	active site
243365009918	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
243365009919	Chitinase C; Region: ChiC; pfam06483
243365009920	transcriptional regulator SgrR; Provisional; Region: PRK13626
243365009921	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
243365009922	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
243365009923	Nitrate and nitrite sensing; Region: NIT; pfam08376
243365009924	HAMP domain; Region: HAMP; pfam00672
243365009925	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243365009926	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365009927	dimer interface [polypeptide binding]; other site
243365009928	putative CheW interface [polypeptide binding]; other site
243365009929	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243365009930	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365009931	dimer interface [polypeptide binding]; other site
243365009932	putative CheW interface [polypeptide binding]; other site
243365009933	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243365009934	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397
243365009935	Chitin binding domain; Region: Chitin_bind_3; pfam03067
243365009936	chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214
243365009937	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
243365009938	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
243365009939	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
243365009940	putative cation:proton antiport protein; Provisional; Region: PRK10669
243365009941	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
243365009942	TrkA-N domain; Region: TrkA_N; pfam02254
243365009943	KpsF/GutQ family protein; Region: kpsF; TIGR00393
243365009944	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
243365009945	putative active site [active]
243365009946	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
243365009947	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
243365009948	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243365009949	active site
243365009950	motif I; other site
243365009951	motif II; other site
243365009952	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
243365009953	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
243365009954	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
243365009955	OstA-like protein; Region: OstA; pfam03968
243365009956	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
243365009957	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
243365009958	Walker A/P-loop; other site
243365009959	ATP binding site [chemical binding]; other site
243365009960	Q-loop/lid; other site
243365009961	ABC transporter signature motif; other site
243365009962	Walker B; other site
243365009963	D-loop; other site
243365009964	H-loop/switch region; other site
243365009965	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
243365009966	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
243365009967	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
243365009968	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
243365009969	30S subunit binding site; other site
243365009970	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
243365009971	active site
243365009972	phosphorylation site [posttranslational modification]
243365009973	HPr kinase/phosphorylase; Provisional; Region: PRK05428
243365009974	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
243365009975	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
243365009976	Hpr binding site; other site
243365009977	active site
243365009978	homohexamer subunit interaction site [polypeptide binding]; other site
243365009979	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
243365009980	aromatic acid decarboxylase; Validated; Region: PRK05920
243365009981	Flavoprotein; Region: Flavoprotein; pfam02441
243365009982	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
243365009983	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
243365009984	putative substrate binding site [chemical binding]; other site
243365009985	putative ATP binding site [chemical binding]; other site
243365009986	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
243365009987	EamA-like transporter family; Region: EamA; pfam00892
243365009988	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243365009989	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
243365009990	dimer interface [polypeptide binding]; other site
243365009991	phosphorylation site [posttranslational modification]
243365009992	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365009993	ATP binding site [chemical binding]; other site
243365009994	Mg2+ binding site [ion binding]; other site
243365009995	G-X-G motif; other site
243365009996	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365009997	active site
243365009998	phosphorylation site [posttranslational modification]
243365009999	intermolecular recognition site; other site
243365010000	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
243365010001	Domain of unknown function (DUF3369); Region: DUF3369; pfam11849
243365010002	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243365010003	Zn2+ binding site [ion binding]; other site
243365010004	Mg2+ binding site [ion binding]; other site
243365010005	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
243365010006	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
243365010007	adenylate kinase; Reviewed; Region: adk; PRK00279
243365010008	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
243365010009	AMP-binding site [chemical binding]; other site
243365010010	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
243365010011	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
243365010012	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
243365010013	Ligand binding site; other site
243365010014	oligomer interface; other site
243365010015	Uncharacterized conserved protein [Function unknown]; Region: COG2835
243365010016	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
243365010017	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
243365010018	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
243365010019	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
243365010020	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
243365010021	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; cl17557
243365010022	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
243365010023	dimerization interface [polypeptide binding]; other site
243365010024	putative DNA binding site [nucleotide binding]; other site
243365010025	putative Zn2+ binding site [ion binding]; other site
243365010026	phosphoglyceromutase; Provisional; Region: PRK05434
243365010027	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
243365010028	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
243365010029	Peptidase family M23; Region: Peptidase_M23; pfam01551
243365010030	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
243365010031	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
243365010032	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
243365010033	protein binding site [polypeptide binding]; other site
243365010034	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
243365010035	Catalytic dyad [active]
243365010036	N-acetylglutamate synthase; Validated; Region: PRK05279
243365010037	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
243365010038	putative feedback inhibition sensing region; other site
243365010039	putative nucleotide binding site [chemical binding]; other site
243365010040	putative substrate binding site [chemical binding]; other site
243365010041	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365010042	Coenzyme A binding pocket [chemical binding]; other site
243365010043	oxidative damage protection protein; Provisional; Region: PRK05408
243365010044	polyphosphate kinase; Provisional; Region: PRK05443
243365010045	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
243365010046	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
243365010047	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
243365010048	putative domain interface [polypeptide binding]; other site
243365010049	putative active site [active]
243365010050	catalytic site [active]
243365010051	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
243365010052	putative domain interface [polypeptide binding]; other site
243365010053	putative active site [active]
243365010054	catalytic site [active]
243365010055	Protein of unknown function (DUF456); Region: DUF456; cl01069
243365010056	Sensors of blue-light using FAD; Region: BLUF; pfam04940
243365010057	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
243365010058	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
243365010059	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
243365010060	ABC transporter; Region: ABC_tran_2; pfam12848
243365010061	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
243365010062	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243365010063	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
243365010064	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
243365010065	Peptidase family M23; Region: Peptidase_M23; pfam01551
243365010066	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
243365010067	hypothetical protein; Provisional; Region: PRK14013
243365010068	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
243365010069	Iron-sulfur protein interface; other site
243365010070	proximal quinone binding site [chemical binding]; other site
243365010071	C-subunit interface; other site
243365010072	distal quinone binding site; other site
243365010073	Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546
243365010074	D-subunit interface [polypeptide binding]; other site
243365010075	Iron-sulfur protein interface; other site
243365010076	proximal quinone binding site [chemical binding]; other site
243365010077	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
243365010078	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
243365010079	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
243365010080	L-aspartate oxidase; Provisional; Region: PRK06175
243365010081	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
243365010082	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
243365010083	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
243365010084	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
243365010085	diiron binding motif [ion binding]; other site
243365010086	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
243365010087	dimer interface [polypeptide binding]; other site
243365010088	substrate binding site [chemical binding]; other site
243365010089	metal binding sites [ion binding]; metal-binding site
243365010090	Phasin protein; Region: Phasin_2; pfam09361
243365010091	septum formation inhibitor; Reviewed; Region: minC; PRK04516
243365010092	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
243365010093	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
243365010094	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
243365010095	Switch I; other site
243365010096	Switch II; other site
243365010097	cell division topological specificity factor MinE; Provisional; Region: PRK13989
243365010098	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365010099	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365010100	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
243365010101	dimerization interface [polypeptide binding]; other site
243365010102	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
243365010103	active site
243365010104	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
243365010105	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
243365010106	active site
243365010107	Zn binding site [ion binding]; other site
243365010108	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
243365010109	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
243365010110	active site
243365010111	Zn binding site [ion binding]; other site
243365010112	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
243365010113	MarR family; Region: MarR_2; pfam12802
243365010114	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
243365010115	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
243365010116	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
243365010117	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_11; cd04669
243365010118	nudix motif; other site
243365010119	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
243365010120	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
243365010121	RNA binding surface [nucleotide binding]; other site
243365010122	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
243365010123	probable active site [active]
243365010124	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
243365010125	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365010126	Coenzyme A binding pocket [chemical binding]; other site
243365010127	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
243365010128	tRNA dimethylallyltransferase; Region: miaA; TIGR00174
243365010129	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
243365010130	putative active site [active]
243365010131	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
243365010132	homotrimer interaction site [polypeptide binding]; other site
243365010133	putative active site [active]
243365010134	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
243365010135	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
243365010136	homodimer interface [polypeptide binding]; other site
243365010137	substrate-cofactor binding pocket; other site
243365010138	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365010139	catalytic residue [active]
243365010140	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
243365010141	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
243365010142	dimer interface [polypeptide binding]; other site
243365010143	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365010144	catalytic residue [active]
243365010145	FOG: CBS domain [General function prediction only]; Region: COG0517
243365010146	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
243365010147	hypothetical protein; Provisional; Region: PRK08317
243365010148	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365010149	S-adenosylmethionine binding site [chemical binding]; other site
243365010150	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
243365010151	Fatty acid desaturase; Region: FA_desaturase; pfam00487
243365010152	Di-iron ligands [ion binding]; other site
243365010153	Transposase; Region: DDE_Tnp_ISL3; pfam01610
243365010154	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
243365010155	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
243365010156	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
243365010157	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
243365010158	heme binding site [chemical binding]; other site
243365010159	ferroxidase pore; other site
243365010160	ferroxidase diiron center [ion binding]; other site
243365010161	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
243365010162	nudix motif; other site
243365010163	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
243365010164	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
243365010165	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365010166	Major Facilitator Superfamily; Region: MFS_1; pfam07690
243365010167	putative substrate translocation pore; other site
243365010168	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
243365010169	dimerization interface [polypeptide binding]; other site
243365010170	substrate binding pocket [chemical binding]; other site
243365010171	putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730
243365010172	classical (c) SDRs; Region: SDR_c; cd05233
243365010173	NAD(P) binding site [chemical binding]; other site
243365010174	active site
243365010175	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
243365010176	prephenate dehydrogenase; Validated; Region: PRK08507
243365010177	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
243365010178	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
243365010179	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
243365010180	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
243365010181	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365010182	catalytic residue [active]
243365010183	hypothetical protein; Validated; Region: PRK09070
243365010184	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
243365010185	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
243365010186	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
243365010187	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
243365010188	dimer interface [polypeptide binding]; other site
243365010189	active site
243365010190	acyl carrier protein; Provisional; Region: acpP; PRK00982
243365010191	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
243365010192	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243365010193	NAD(P) binding site [chemical binding]; other site
243365010194	active site
243365010195	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
243365010196	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
243365010197	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
243365010198	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
243365010199	dimer interface [polypeptide binding]; other site
243365010200	active site
243365010201	CoA binding pocket [chemical binding]; other site
243365010202	putative phosphate acyltransferase; Provisional; Region: PRK05331
243365010203	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
243365010204	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
243365010205	Maf-like protein; Region: Maf; pfam02545
243365010206	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
243365010207	active site
243365010208	dimer interface [polypeptide binding]; other site
243365010209	Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649
243365010210	putative SAM binding site [chemical binding]; other site
243365010211	homodimer interface [polypeptide binding]; other site
243365010212	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
243365010213	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
243365010214	active site
243365010215	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
243365010216	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
243365010217	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
243365010218	trimer interface [polypeptide binding]; other site
243365010219	eyelet of channel; other site
243365010220	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243365010221	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
243365010222	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
243365010223	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
243365010224	peptide binding site [polypeptide binding]; other site
243365010225	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
243365010226	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365010227	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365010228	metal binding site [ion binding]; metal-binding site
243365010229	active site
243365010230	I-site; other site
243365010231	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243365010232	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365010233	S-adenosylmethionine binding site [chemical binding]; other site
243365010234	glycine dehydrogenase; Provisional; Region: PRK05367
243365010235	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
243365010236	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
243365010237	catalytic residue [active]
243365010238	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
243365010239	tetramer interface [polypeptide binding]; other site
243365010240	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365010241	catalytic residue [active]
243365010242	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
243365010243	lipoyl attachment site [posttranslational modification]; other site
243365010244	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
243365010245	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
243365010246	arginine:agmatin antiporter; Provisional; Region: PRK10644
243365010247	glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838
243365010248	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
243365010249	active site
243365010250	HIGH motif; other site
243365010251	nucleotide binding site [chemical binding]; other site
243365010252	active site
243365010253	KMSKS motif; other site
243365010254	Ferredoxin [Energy production and conversion]; Region: COG1146
243365010255	4Fe-4S binding domain; Region: Fer4; pfam00037
243365010256	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
243365010257	CheD chemotactic sensory transduction; Region: CheD; cl00810
243365010258	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
243365010259	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365010260	active site
243365010261	phosphorylation site [posttranslational modification]
243365010262	intermolecular recognition site; other site
243365010263	dimerization interface [polypeptide binding]; other site
243365010264	CheB methylesterase; Region: CheB_methylest; pfam01339
243365010265	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
243365010266	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
243365010267	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365010268	PAS domain; Region: PAS_9; pfam13426
243365010269	PAS domain; Region: PAS_9; pfam13426
243365010270	PAS domain; Region: PAS_9; pfam13426
243365010271	PAS domain; Region: PAS; smart00091
243365010272	PAS domain; Region: PAS_9; pfam13426
243365010273	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365010274	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243365010275	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365010276	dimer interface [polypeptide binding]; other site
243365010277	putative CheW interface [polypeptide binding]; other site
243365010278	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
243365010279	putative CheA interaction surface; other site
243365010280	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
243365010281	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
243365010282	putative binding surface; other site
243365010283	active site
243365010284	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
243365010285	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365010286	ATP binding site [chemical binding]; other site
243365010287	Mg2+ binding site [ion binding]; other site
243365010288	G-X-G motif; other site
243365010289	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
243365010290	Response regulator receiver domain; Region: Response_reg; pfam00072
243365010291	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365010292	active site
243365010293	phosphorylation site [posttranslational modification]
243365010294	intermolecular recognition site; other site
243365010295	dimerization interface [polypeptide binding]; other site
243365010296	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
243365010297	anti sigma factor interaction site; other site
243365010298	regulatory phosphorylation site [posttranslational modification]; other site
243365010299	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
243365010300	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243365010301	phosphorylation site [posttranslational modification]
243365010302	dimer interface [polypeptide binding]; other site
243365010303	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365010304	ATP binding site [chemical binding]; other site
243365010305	Mg2+ binding site [ion binding]; other site
243365010306	G-X-G motif; other site
243365010307	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
243365010308	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
243365010309	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365010310	active site
243365010311	phosphorylation site [posttranslational modification]
243365010312	intermolecular recognition site; other site
243365010313	dimerization interface [polypeptide binding]; other site
243365010314	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
243365010315	Response regulator receiver domain; Region: Response_reg; pfam00072
243365010316	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365010317	active site
243365010318	phosphorylation site [posttranslational modification]
243365010319	intermolecular recognition site; other site
243365010320	dimerization interface [polypeptide binding]; other site
243365010321	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
243365010322	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365010323	active site
243365010324	phosphorylation site [posttranslational modification]
243365010325	intermolecular recognition site; other site
243365010326	dimerization interface [polypeptide binding]; other site
243365010327	chemotaxis regulator CheZ; Provisional; Region: PRK11166
243365010328	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
243365010329	putative binding surface; other site
243365010330	active site
243365010331	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
243365010332	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
243365010333	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365010334	ATP binding site [chemical binding]; other site
243365010335	Mg2+ binding site [ion binding]; other site
243365010336	G-X-G motif; other site
243365010337	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
243365010338	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
243365010339	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243365010340	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
243365010341	Glycoprotease family; Region: Peptidase_M22; pfam00814
243365010342	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
243365010343	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365010344	Coenzyme A binding pocket [chemical binding]; other site
243365010345	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
243365010346	Fe-S cluster binding site [ion binding]; other site
243365010347	active site
243365010348	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
243365010349	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
243365010350	CTP synthetase; Validated; Region: pyrG; PRK05380
243365010351	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
243365010352	Catalytic site [active]
243365010353	active site
243365010354	UTP binding site [chemical binding]; other site
243365010355	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
243365010356	active site
243365010357	putative oxyanion hole; other site
243365010358	catalytic triad [active]
243365010359	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
243365010360	metal binding site [ion binding]; metal-binding site
243365010361	substrate binding pocket [chemical binding]; other site
243365010362	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
243365010363	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
243365010364	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365010365	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365010366	metal binding site [ion binding]; metal-binding site
243365010367	active site
243365010368	I-site; other site
243365010369	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914
243365010370	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
243365010371	putative coenzyme Q binding site [chemical binding]; other site
243365010372	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
243365010373	SmpB-tmRNA interface; other site
243365010374	GMP synthase; Reviewed; Region: guaA; PRK00074
243365010375	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
243365010376	AMP/PPi binding site [chemical binding]; other site
243365010377	candidate oxyanion hole; other site
243365010378	catalytic triad [active]
243365010379	potential glutamine specificity residues [chemical binding]; other site
243365010380	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
243365010381	ATP Binding subdomain [chemical binding]; other site
243365010382	Ligand Binding sites [chemical binding]; other site
243365010383	Dimerization subdomain; other site
243365010384	metabolite-proton symporter; Region: 2A0106; TIGR00883
243365010385	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365010386	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365010387	Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957
243365010388	TfoX C-terminal domain; Region: TfoX_C; pfam04994
243365010389	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
243365010390	nucleoside/Zn binding site; other site
243365010391	dimer interface [polypeptide binding]; other site
243365010392	catalytic motif [active]
243365010393	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
243365010394	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
243365010395	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
243365010396	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365010397	S-adenosylmethionine binding site [chemical binding]; other site
243365010398	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
243365010399	Fumarase C-terminus; Region: Fumerase_C; pfam05683
243365010400	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
243365010401	MgtC family; Region: MgtC; pfam02308
243365010402	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
243365010403	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
243365010404	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
243365010405	EamA-like transporter family; Region: EamA; pfam00892
243365010406	EamA-like transporter family; Region: EamA; pfam00892
243365010407	Cupin domain; Region: Cupin_2; cl17218
243365010408	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
243365010409	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
243365010410	DNA photolyase; Region: DNA_photolyase; pfam00875
243365010411	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
243365010412	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365010413	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365010414	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
243365010415	putative effector binding pocket; other site
243365010416	dimerization interface [polypeptide binding]; other site
243365010417	Protein of unknown function, DUF606; Region: DUF606; pfam04657
243365010418	Protein of unknown function, DUF606; Region: DUF606; pfam04657
243365010419	hypothetical protein; Provisional; Region: PRK02237
243365010420	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
243365010421	dimer interface [polypeptide binding]; other site
243365010422	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
243365010423	metal binding site [ion binding]; metal-binding site
243365010424	Predicted transcriptional regulator [Transcription]; Region: COG1959
243365010425	Transcriptional regulator; Region: Rrf2; cl17282
243365010426	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
243365010427	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
243365010428	heme-binding site [chemical binding]; other site
243365010429	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
243365010430	FAD binding pocket [chemical binding]; other site
243365010431	FAD binding motif [chemical binding]; other site
243365010432	phosphate binding motif [ion binding]; other site
243365010433	beta-alpha-beta structure motif; other site
243365010434	NAD binding pocket [chemical binding]; other site
243365010435	Heme binding  pocket [chemical binding]; other site
243365010436	Chitin binding domain; Region: Chitin_bind_3; pfam03067
243365010437	Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430
243365010438	Domain interface; other site
243365010439	glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535
243365010440	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
243365010441	Alpha-amylase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. This domain is found in several bacterial and fungal alpha-amylases including the maltopentaose-forming amylases (G5-amylases). Most alpha-amylases have, in addition to the...; Region: CBM20_alpha_amylase; cd05808
243365010442	starch-binding site 2 [chemical binding]; other site
243365010443	starch-binding site 1 [chemical binding]; other site
243365010444	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
243365010445	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365010446	Coenzyme A binding pocket [chemical binding]; other site
243365010447	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
243365010448	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
243365010449	Binuclear center (active site) [active]
243365010450	K-pathway; other site
243365010451	Putative proton exit pathway; other site
243365010452	High-affinity nickel-transport protein; Region: NicO; cl00964
243365010453	High-affinity nickel-transport protein; Region: NicO; cl00964
243365010454	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
243365010455	putative metal binding site [ion binding]; other site
243365010456	putative homodimer interface [polypeptide binding]; other site
243365010457	putative homotetramer interface [polypeptide binding]; other site
243365010458	putative homodimer-homodimer interface [polypeptide binding]; other site
243365010459	putative allosteric switch controlling residues; other site
243365010460	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
243365010461	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
243365010462	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
243365010463	active site
243365010464	metal binding site [ion binding]; metal-binding site
243365010465	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243365010466	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
243365010467	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
243365010468	dimer interface [polypeptide binding]; other site
243365010469	FMN binding site [chemical binding]; other site
243365010470	NADPH bind site [chemical binding]; other site
243365010471	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
243365010472	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
243365010473	FMN binding site [chemical binding]; other site
243365010474	active site
243365010475	substrate binding site [chemical binding]; other site
243365010476	catalytic residue [active]
243365010477	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
243365010478	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
243365010479	PAS domain S-box; Region: sensory_box; TIGR00229
243365010480	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365010481	putative active site [active]
243365010482	heme pocket [chemical binding]; other site
243365010483	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365010484	PAS domain; Region: PAS_9; pfam13426
243365010485	putative active site [active]
243365010486	heme pocket [chemical binding]; other site
243365010487	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
243365010488	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243365010489	putative active site [active]
243365010490	heme pocket [chemical binding]; other site
243365010491	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243365010492	dimer interface [polypeptide binding]; other site
243365010493	phosphorylation site [posttranslational modification]
243365010494	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365010495	ATP binding site [chemical binding]; other site
243365010496	Mg2+ binding site [ion binding]; other site
243365010497	G-X-G motif; other site
243365010498	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365010499	Response regulator receiver domain; Region: Response_reg; pfam00072
243365010500	active site
243365010501	phosphorylation site [posttranslational modification]
243365010502	intermolecular recognition site; other site
243365010503	dimerization interface [polypeptide binding]; other site
243365010504	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
243365010505	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365010506	active site
243365010507	phosphorylation site [posttranslational modification]
243365010508	intermolecular recognition site; other site
243365010509	dimerization interface [polypeptide binding]; other site
243365010510	Response regulator receiver domain; Region: Response_reg; pfam00072
243365010511	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365010512	active site
243365010513	phosphorylation site [posttranslational modification]
243365010514	intermolecular recognition site; other site
243365010515	dimerization interface [polypeptide binding]; other site
243365010516	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365010517	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365010518	metal binding site [ion binding]; metal-binding site
243365010519	active site
243365010520	I-site; other site
243365010521	Response regulator receiver domain; Region: Response_reg; pfam00072
243365010522	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365010523	active site
243365010524	phosphorylation site [posttranslational modification]
243365010525	intermolecular recognition site; other site
243365010526	dimerization interface [polypeptide binding]; other site
243365010527	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
243365010528	Peptidase M35 domain of peptidyl-Lys metalloendopeptidases; Region: M35_peptidyl-Lys; cd11306
243365010529	active site
243365010530	Zn binding site [ion binding]; other site
243365010531	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
243365010532	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
243365010533	Ligand Binding Site [chemical binding]; other site
243365010534	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
243365010535	active site
243365010536	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
243365010537	active site
243365010538	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
243365010539	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243365010540	FeS/SAM binding site; other site
243365010541	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
243365010542	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
243365010543	hypothetical protein; Provisional; Region: PRK05409
243365010544	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
243365010545	phosphoserine phosphatase SerB; Region: serB; TIGR00338
243365010546	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243365010547	motif II; other site
243365010548	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
243365010549	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243365010550	FeS/SAM binding site; other site
243365010551	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
243365010552	Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377
243365010553	peptidase domain interface [polypeptide binding]; other site
243365010554	Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056
243365010555	active site
243365010556	catalytic triad [active]
243365010557	calcium binding site [ion binding]; other site
243365010558	acetoacetate decarboxylase; Provisional; Region: PRK02265
243365010559	putative oxidoreductase; Provisional; Region: PRK11579
243365010560	LabA_like proteins; Region: LabA_like; cd06167
243365010561	putative metal binding site [ion binding]; other site
243365010562	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
243365010563	ribonuclease R; Region: RNase_R; TIGR02063
243365010564	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
243365010565	RNB domain; Region: RNB; pfam00773
243365010566	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
243365010567	RNA binding site [nucleotide binding]; other site
243365010568	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365010569	putative transporter; Provisional; Region: PRK10504
243365010570	putative substrate translocation pore; other site
243365010571	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365010572	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
243365010573	acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397
243365010574	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
243365010575	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
243365010576	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238
243365010577	dimer interface [polypeptide binding]; other site
243365010578	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
243365010579	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
243365010580	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
243365010581	GDP-binding site [chemical binding]; other site
243365010582	ACT binding site; other site
243365010583	IMP binding site; other site
243365010584	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421
243365010585	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
243365010586	dimer interface [polypeptide binding]; other site
243365010587	motif 1; other site
243365010588	active site
243365010589	motif 2; other site
243365010590	motif 3; other site
243365010591	HflC protein; Region: hflC; TIGR01932
243365010592	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
243365010593	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
243365010594	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
243365010595	HflK protein; Region: hflK; TIGR01933
243365010596	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
243365010597	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
243365010598	HflX GTPase family; Region: HflX; cd01878
243365010599	G1 box; other site
243365010600	GTP/Mg2+ binding site [chemical binding]; other site
243365010601	Switch I region; other site
243365010602	G2 box; other site
243365010603	G3 box; other site
243365010604	Switch II region; other site
243365010605	G4 box; other site
243365010606	G5 box; other site
243365010607	bacterial Hfq-like; Region: Hfq; cd01716
243365010608	hexamer interface [polypeptide binding]; other site
243365010609	Sm1 motif; other site
243365010610	RNA binding site [nucleotide binding]; other site
243365010611	Sm2 motif; other site
243365010612	GTP-binding protein Der; Reviewed; Region: PRK00093
243365010613	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
243365010614	G1 box; other site
243365010615	GTP/Mg2+ binding site [chemical binding]; other site
243365010616	Switch I region; other site
243365010617	G2 box; other site
243365010618	Switch II region; other site
243365010619	G3 box; other site
243365010620	G4 box; other site
243365010621	G5 box; other site
243365010622	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
243365010623	G1 box; other site
243365010624	GTP/Mg2+ binding site [chemical binding]; other site
243365010625	Switch I region; other site
243365010626	G2 box; other site
243365010627	G3 box; other site
243365010628	Switch II region; other site
243365010629	G4 box; other site
243365010630	G5 box; other site
243365010631	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
243365010632	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
243365010633	Trp docking motif [polypeptide binding]; other site
243365010634	active site
243365010635	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
243365010636	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
243365010637	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
243365010638	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
243365010639	dimer interface [polypeptide binding]; other site
243365010640	motif 1; other site
243365010641	active site
243365010642	motif 2; other site
243365010643	motif 3; other site
243365010644	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
243365010645	anticodon binding site; other site
243365010646	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
243365010647	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
243365010648	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
243365010649	Helix-turn-helix domain; Region: HTH_25; pfam13413
243365010650	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
243365010651	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
243365010652	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243365010653	binding surface
243365010654	TPR motif; other site
243365010655	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243365010656	TPR motif; other site
243365010657	binding surface
243365010658	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
243365010659	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243365010660	FeS/SAM binding site; other site
243365010661	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
243365010662	active site
243365010663	multimer interface [polypeptide binding]; other site
243365010664	Sporulation related domain; Region: SPOR; pfam05036
243365010665	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
243365010666	Putative exonuclease, RdgC; Region: RdgC; pfam04381
243365010667	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
243365010668	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
243365010669	tetramer interface [polypeptide binding]; other site
243365010670	heme binding pocket [chemical binding]; other site
243365010671	NADPH binding site [chemical binding]; other site
243365010672	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
243365010673	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
243365010674	putative active site [active]
243365010675	metal binding site [ion binding]; metal-binding site
243365010676	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
243365010677	Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741
243365010678	active site
243365010679	FMN binding site [chemical binding]; other site
243365010680	substrate binding site [chemical binding]; other site
243365010681	catalytic residues [active]
243365010682	homodimer interface [polypeptide binding]; other site
243365010683	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
243365010684	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
243365010685	heme binding site [chemical binding]; other site
243365010686	ferroxidase pore; other site
243365010687	ferroxidase diiron center [ion binding]; other site
243365010688	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
243365010689	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
243365010690	G1 box; other site
243365010691	GTP/Mg2+ binding site [chemical binding]; other site
243365010692	Switch I region; other site
243365010693	G2 box; other site
243365010694	G3 box; other site
243365010695	Switch II region; other site
243365010696	G4 box; other site
243365010697	G5 box; other site
243365010698	Nucleoside recognition; Region: Gate; pfam07670
243365010699	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
243365010700	Nucleoside recognition; Region: Gate; pfam07670
243365010701	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
243365010702	trimer interface [polypeptide binding]; other site
243365010703	active site
243365010704	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
243365010705	catalytic residues [active]
243365010706	dimer interface [polypeptide binding]; other site
243365010707	Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001
243365010708	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
243365010709	active site
243365010710	Zn binding site [ion binding]; other site
243365010711	hypothetical protein; Provisional; Region: PRK04233
243365010712	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
243365010713	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
243365010714	dimer interface [polypeptide binding]; other site
243365010715	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365010716	catalytic residue [active]
243365010717	Ion transport protein; Region: Ion_trans; pfam00520
243365010718	Ion channel; Region: Ion_trans_2; pfam07885
243365010719	Double zinc ribbon; Region: DZR; pfam12773
243365010720	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
243365010721	putative ADP-ribose binding site [chemical binding]; other site
243365010722	putative active site [active]
243365010723	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
243365010724	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
243365010725	generic binding surface II; other site
243365010726	generic binding surface I; other site
243365010727	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
243365010728	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
243365010729	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
243365010730	lipoprotein signal peptidase; Provisional; Region: PRK14787
243365010731	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
243365010732	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
243365010733	active site
243365010734	HIGH motif; other site
243365010735	nucleotide binding site [chemical binding]; other site
243365010736	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
243365010737	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
243365010738	active site
243365010739	KMSKS motif; other site
243365010740	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
243365010741	tRNA binding surface [nucleotide binding]; other site
243365010742	anticodon binding site; other site
243365010743	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
243365010744	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
243365010745	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
243365010746	active site
243365010747	Riboflavin kinase; Region: Flavokinase; smart00904
243365010748	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
243365010749	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
243365010750	ligand binding site [chemical binding]; other site
243365010751	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
243365010752	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
243365010753	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
243365010754	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
243365010755	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
243365010756	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
243365010757	Active Sites [active]
243365010758	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684
243365010759	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365010760	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
243365010761	substrate binding site [chemical binding]; other site
243365010762	dimerization interface [polypeptide binding]; other site
243365010763	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
243365010764	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
243365010765	NAD(P) binding site [chemical binding]; other site
243365010766	homotetramer interface [polypeptide binding]; other site
243365010767	homodimer interface [polypeptide binding]; other site
243365010768	active site
243365010769	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
243365010770	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243365010771	Walker A/P-loop; other site
243365010772	ATP binding site [chemical binding]; other site
243365010773	Q-loop/lid; other site
243365010774	ABC transporter signature motif; other site
243365010775	Walker B; other site
243365010776	D-loop; other site
243365010777	H-loop/switch region; other site
243365010778	ABC transporter; Region: ABC_tran_2; pfam12848
243365010779	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
243365010780	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
243365010781	dihydrodipicolinate synthase; Region: dapA; TIGR00674
243365010782	dimer interface [polypeptide binding]; other site
243365010783	active site
243365010784	catalytic residue [active]
243365010785	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
243365010786	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
243365010787	Cupin superfamily protein; Region: Cupin_4; pfam08007
243365010788	Cupin-like domain; Region: Cupin_8; pfam13621
243365010789	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
243365010790	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
243365010791	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
243365010792	active site
243365010793	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
243365010794	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365010795	S-adenosylmethionine binding site [chemical binding]; other site
243365010796	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
243365010797	MgtE intracellular N domain; Region: MgtE_N; smart00924
243365010798	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
243365010799	Divalent cation transporter; Region: MgtE; cl00786
243365010800	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
243365010801	monofunctional biosynthetic peptidoglycan transglycosylase; Region: mono_pep_trsgly; TIGR02070
243365010802	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
243365010803	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
243365010804	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
243365010805	shikimate binding site; other site
243365010806	NAD(P) binding site [chemical binding]; other site
243365010807	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
243365010808	active site residue [active]
243365010809	glutamine synthetase; Provisional; Region: glnA; PRK09469
243365010810	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
243365010811	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
243365010812	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
243365010813	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
243365010814	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243365010815	dimer interface [polypeptide binding]; other site
243365010816	phosphorylation site [posttranslational modification]
243365010817	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365010818	ATP binding site [chemical binding]; other site
243365010819	Mg2+ binding site [ion binding]; other site
243365010820	G-X-G motif; other site
243365010821	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
243365010822	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365010823	active site
243365010824	phosphorylation site [posttranslational modification]
243365010825	intermolecular recognition site; other site
243365010826	dimerization interface [polypeptide binding]; other site
243365010827	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243365010828	Walker A motif; other site
243365010829	ATP binding site [chemical binding]; other site
243365010830	Walker B motif; other site
243365010831	arginine finger; other site
243365010832	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
243365010833	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243365010834	The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6,  and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348
243365010835	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
243365010836	putative active site [active]
243365010837	putative metal binding site [ion binding]; other site
243365010838	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
243365010839	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
243365010840	catalytic residue [active]
243365010841	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
243365010842	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
243365010843	active site
243365010844	AMP binding site [chemical binding]; other site
243365010845	acyl-activating enzyme (AAE) consensus motif; other site
243365010846	CoA binding site [chemical binding]; other site
243365010847	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
243365010848	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
243365010849	benzoate transport; Region: 2A0115; TIGR00895
243365010850	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365010851	putative substrate translocation pore; other site
243365010852	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365010853	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
243365010854	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365010855	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
243365010856	putative dimerization interface [polypeptide binding]; other site
243365010857	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
243365010858	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
243365010859	THF binding site; other site
243365010860	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
243365010861	substrate binding site [chemical binding]; other site
243365010862	THF binding site; other site
243365010863	zinc-binding site [ion binding]; other site
243365010864	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
243365010865	catalytic core [active]
243365010866	LrgB-like family; Region: LrgB; pfam04172
243365010867	LrgA family; Region: LrgA; pfam03788
243365010868	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
243365010869	UbiA prenyltransferase family; Region: UbiA; pfam01040
243365010870	hypothetical protein; Provisional; Region: PRK08999
243365010871	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
243365010872	active site
243365010873	8-oxo-dGMP binding site [chemical binding]; other site
243365010874	nudix motif; other site
243365010875	metal binding site [ion binding]; metal-binding site
243365010876	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
243365010877	thiamine phosphate binding site [chemical binding]; other site
243365010878	active site
243365010879	pyrophosphate binding site [ion binding]; other site
243365010880	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
243365010881	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243365010882	Walker A motif; other site
243365010883	ATP binding site [chemical binding]; other site
243365010884	Walker B motif; other site
243365010885	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
243365010886	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
243365010887	DnaA regulatory inactivator Hda; Validated; Region: PRK08903
243365010888	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
243365010889	Walker A motif; other site
243365010890	ATP binding site [chemical binding]; other site
243365010891	Walker B motif; other site
243365010892	arginine finger; other site
243365010893	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
243365010894	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
243365010895	dimerization interface [polypeptide binding]; other site
243365010896	putative ATP binding site [chemical binding]; other site
243365010897	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
243365010898	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
243365010899	active site
243365010900	substrate binding site [chemical binding]; other site
243365010901	cosubstrate binding site; other site
243365010902	catalytic site [active]
243365010903	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
243365010904	16S rRNA methyltransferase B; Provisional; Region: PRK14901
243365010905	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
243365010906	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
243365010907	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
243365010908	putative ion selectivity filter; other site
243365010909	putative pore gating glutamate residue; other site
243365010910	putative H+/Cl- coupling transport residue; other site
243365010911	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
243365010912	putative GSH binding site [chemical binding]; other site
243365010913	catalytic residues [active]
243365010914	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
243365010915	active site
243365010916	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
243365010917	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365010918	Coenzyme A binding pocket [chemical binding]; other site
243365010919	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
243365010920	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365010921	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
243365010922	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
243365010923	dimerization interface [polypeptide binding]; other site
243365010924	putative acetyltransferase YhhY; Provisional; Region: PRK10140
243365010925	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
243365010926	putative acetyltransferase YhhY; Provisional; Region: PRK10140
243365010927	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365010928	Coenzyme A binding pocket [chemical binding]; other site
243365010929	putative acetyltransferase YhhY; Provisional; Region: PRK10140
243365010930	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365010931	Coenzyme A binding pocket [chemical binding]; other site
243365010932	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
243365010933	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
243365010934	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
243365010935	Isochorismatase family; Region: Isochorismatase; pfam00857
243365010936	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
243365010937	catalytic triad [active]
243365010938	dimer interface [polypeptide binding]; other site
243365010939	conserved cis-peptide bond; other site
243365010940	Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084
243365010941	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
243365010942	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
243365010943	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
243365010944	MarR family; Region: MarR_2; pfam12802
243365010945	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
243365010946	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
243365010947	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
243365010948	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
243365010949	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
243365010950	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
243365010951	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
243365010952	putative homodimer interface [polypeptide binding]; other site
243365010953	putative homotetramer interface [polypeptide binding]; other site
243365010954	putative allosteric switch controlling residues; other site
243365010955	putative metal binding site [ion binding]; other site
243365010956	putative homodimer-homodimer interface [polypeptide binding]; other site
243365010957	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
243365010958	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
243365010959	Multicopper oxidase; Region: Cu-oxidase; pfam00394
243365010960	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
243365010961	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
243365010962	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
243365010963	active site
243365010964	dimerization interface [polypeptide binding]; other site
243365010965	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
243365010966	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
243365010967	Domain of unknown function (DUF1853); Region: DUF1853; pfam08907
243365010968	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
243365010969	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
243365010970	ligand binding site [chemical binding]; other site
243365010971	flexible hinge region; other site
243365010972	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
243365010973	putative switch regulator; other site
243365010974	non-specific DNA interactions [nucleotide binding]; other site
243365010975	DNA binding site [nucleotide binding]
243365010976	sequence specific DNA binding site [nucleotide binding]; other site
243365010977	putative cAMP binding site [chemical binding]; other site
243365010978	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
243365010979	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243365010980	FeS/SAM binding site; other site
243365010981	HemN C-terminal domain; Region: HemN_C; pfam06969
243365010982	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
243365010983	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243365010984	dimerization interface [polypeptide binding]; other site
243365010985	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365010986	dimer interface [polypeptide binding]; other site
243365010987	putative CheW interface [polypeptide binding]; other site
243365010988	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
243365010989	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
243365010990	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243365010991	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243365010992	substrate binding pocket [chemical binding]; other site
243365010993	membrane-bound complex binding site; other site
243365010994	hinge residues; other site
243365010995	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
243365010996	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
243365010997	putative active site [active]
243365010998	putative metal binding site [ion binding]; other site
243365010999	catalytic site [active]
243365011000	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
243365011001	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
243365011002	Walker A/P-loop; other site
243365011003	ATP binding site [chemical binding]; other site
243365011004	Q-loop/lid; other site
243365011005	ABC transporter signature motif; other site
243365011006	Walker B; other site
243365011007	D-loop; other site
243365011008	H-loop/switch region; other site
243365011009	TOBE domain; Region: TOBE_2; pfam08402
243365011010	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
243365011011	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365011012	dimer interface [polypeptide binding]; other site
243365011013	conserved gate region; other site
243365011014	putative PBP binding loops; other site
243365011015	ABC-ATPase subunit interface; other site
243365011016	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
243365011017	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365011018	dimer interface [polypeptide binding]; other site
243365011019	conserved gate region; other site
243365011020	putative PBP binding loops; other site
243365011021	ABC-ATPase subunit interface; other site
243365011022	glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974
243365011023	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
243365011024	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
243365011025	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
243365011026	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
243365011027	Predicted transcriptional regulators [Transcription]; Region: COG1510
243365011028	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
243365011029	dimerization interface [polypeptide binding]; other site
243365011030	putative DNA binding site [nucleotide binding]; other site
243365011031	putative Zn2+ binding site [ion binding]; other site
243365011032	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
243365011033	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
243365011034	MOFRL family; Region: MOFRL; pfam05161
243365011035	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
243365011036	MutS domain I; Region: MutS_I; pfam01624
243365011037	MutS domain II; Region: MutS_II; pfam05188
243365011038	MutS domain III; Region: MutS_III; pfam05192
243365011039	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
243365011040	Walker A/P-loop; other site
243365011041	ATP binding site [chemical binding]; other site
243365011042	Q-loop/lid; other site
243365011043	ABC transporter signature motif; other site
243365011044	Walker B; other site
243365011045	D-loop; other site
243365011046	H-loop/switch region; other site
243365011047	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
243365011048	pseudouridine synthase; Region: TIGR00093
243365011049	active site
243365011050	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
243365011051	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
243365011052	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365011053	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365011054	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
243365011055	dimerization interface [polypeptide binding]; other site
243365011056	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
243365011057	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
243365011058	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
243365011059	DNA-binding site [nucleotide binding]; DNA binding site
243365011060	RNA-binding motif; other site
243365011061	Uncharacterized conserved protein [Function unknown]; Region: COG2127
243365011062	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
243365011063	Clp amino terminal domain; Region: Clp_N; pfam02861
243365011064	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243365011065	Walker A motif; other site
243365011066	ATP binding site [chemical binding]; other site
243365011067	Walker B motif; other site
243365011068	arginine finger; other site
243365011069	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243365011070	Walker A motif; other site
243365011071	ATP binding site [chemical binding]; other site
243365011072	Walker B motif; other site
243365011073	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
243365011074	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
243365011075	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
243365011076	active site
243365011077	Int/Topo IB signature motif; other site
243365011078	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
243365011079	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
243365011080	DNA binding site [nucleotide binding]
243365011081	active site
243365011082	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
243365011083	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
243365011084	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
243365011085	RimM N-terminal domain; Region: RimM; pfam01782
243365011086	PRC-barrel domain; Region: PRC; pfam05239
243365011087	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
243365011088	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
243365011089	CoA binding domain; Region: CoA_binding_2; pfam13380
243365011090	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
243365011091	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
243365011092	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
243365011093	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365011094	Coenzyme A binding pocket [chemical binding]; other site
243365011095	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
243365011096	quinolinate synthetase; Provisional; Region: PRK09375
243365011097	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
243365011098	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
243365011099	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365011100	S-adenosylmethionine binding site [chemical binding]; other site
243365011101	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
243365011102	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
243365011103	Peptidase family M23; Region: Peptidase_M23; pfam01551
243365011104	RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394
243365011105	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
243365011106	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
243365011107	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
243365011108	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
243365011109	DNA binding residues [nucleotide binding]
243365011110	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
243365011111	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
243365011112	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
243365011113	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
243365011114	Protein of unknown function DUF58; Region: DUF58; pfam01882
243365011115	MoxR-like ATPases [General function prediction only]; Region: COG0714
243365011116	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243365011117	Walker A motif; other site
243365011118	ATP binding site [chemical binding]; other site
243365011119	Walker B motif; other site
243365011120	arginine finger; other site
243365011121	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
243365011122	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
243365011123	putative active site [active]
243365011124	Zn binding site [ion binding]; other site
243365011125	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
243365011126	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
243365011127	Catalytic site [active]
243365011128	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
243365011129	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
243365011130	Dihydroneopterin aldolase; Region: FolB; smart00905
243365011131	active site
243365011132	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
243365011133	apolar tunnel; other site
243365011134	heme binding site [chemical binding]; other site
243365011135	dimerization interface [polypeptide binding]; other site
243365011136	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
243365011137	chemotaxis methyltransferase CheR; Provisional; Region: PRK10611
243365011138	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
243365011139	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
243365011140	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
243365011141	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
243365011142	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
243365011143	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
243365011144	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
243365011145	23S rRNA interface [nucleotide binding]; other site
243365011146	L3 interface [polypeptide binding]; other site
243365011147	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
243365011148	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
243365011149	phosphopentomutase; Provisional; Region: PRK05362
243365011150	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
243365011151	thymidine phosphorylase; Region: T_phosphoryl; TIGR02643
243365011152	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
243365011153	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
243365011154	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
243365011155	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
243365011156	intersubunit interface [polypeptide binding]; other site
243365011157	active site
243365011158	catalytic residue [active]
243365011159	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
243365011160	HD domain; Region: HD_4; pfam13328
243365011161	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
243365011162	synthetase active site [active]
243365011163	NTP binding site [chemical binding]; other site
243365011164	metal binding site [ion binding]; metal-binding site
243365011165	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
243365011166	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
243365011167	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
243365011168	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
243365011169	minor groove reading motif; other site
243365011170	helix-hairpin-helix signature motif; other site
243365011171	active site
243365011172	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
243365011173	DNA binding and oxoG recognition site [nucleotide binding]
243365011174	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
243365011175	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
243365011176	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
243365011177	MarC family integral membrane protein; Region: MarC; cl00919
243365011178	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
243365011179	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
243365011180	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
243365011181	phosphoenolpyruvate synthase; Validated; Region: PRK06464
243365011182	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
243365011183	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
243365011184	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
243365011185	PEP synthetase regulatory protein; Provisional; Region: PRK05339
243365011186	translation initiation factor Sui1; Validated; Region: PRK06824
243365011187	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
243365011188	putative rRNA binding site [nucleotide binding]; other site
243365011189	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
243365011190	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
243365011191	SnoaL-like domain; Region: SnoaL_2; pfam12680
243365011192	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
243365011193	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
243365011194	active site
243365011195	HIGH motif; other site
243365011196	dimer interface [polypeptide binding]; other site
243365011197	KMSKS motif; other site
243365011198	Chorismate mutase type II; Region: CM_2; pfam01817
243365011199	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045
243365011200	CreA protein; Region: CreA; pfam05981
243365011201	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
243365011202	putative hydrolase; Provisional; Region: PRK02113
243365011203	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
243365011204	active site
243365011205	PilZ domain; Region: PilZ; cl01260
243365011206	DNA polymerase III subunit delta'; Validated; Region: PRK08699
243365011207	DNA polymerase III subunit delta'; Validated; Region: PRK08485
243365011208	thymidylate kinase; Validated; Region: tmk; PRK00698
243365011209	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
243365011210	TMP-binding site; other site
243365011211	ATP-binding site [chemical binding]; other site
243365011212	YceG-like family; Region: YceG; pfam02618
243365011213	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
243365011214	dimerization interface [polypeptide binding]; other site
243365011215	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
243365011216	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
243365011217	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
243365011218	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365011219	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
243365011220	dimer interface [polypeptide binding]; other site
243365011221	conserved gate region; other site
243365011222	putative PBP binding loops; other site
243365011223	ABC-ATPase subunit interface; other site
243365011224	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
243365011225	Transcriptional regulators [Transcription]; Region: FadR; COG2186
243365011226	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
243365011227	DNA-binding site [nucleotide binding]; DNA binding site
243365011228	FCD domain; Region: FCD; pfam07729
243365011229	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
243365011230	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365011231	Protein of unknown function (DUF2946); Region: DUF2944; pfam11161
243365011232	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
243365011233	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
243365011234	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
243365011235	Walker A/P-loop; other site
243365011236	ATP binding site [chemical binding]; other site
243365011237	Q-loop/lid; other site
243365011238	ABC transporter signature motif; other site
243365011239	Walker B; other site
243365011240	D-loop; other site
243365011241	H-loop/switch region; other site
243365011242	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
243365011243	active site
243365011244	catalytic triad [active]
243365011245	oxyanion hole [active]
243365011246	switch loop; other site
243365011247	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365011248	Major Facilitator Superfamily; Region: MFS_1; pfam07690
243365011249	putative substrate translocation pore; other site
243365011250	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365011251	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365011252	metal binding site [ion binding]; metal-binding site
243365011253	active site
243365011254	I-site; other site
243365011255	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365011256	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365011257	metal binding site [ion binding]; metal-binding site
243365011258	active site
243365011259	I-site; other site
243365011260	peroxidase; Provisional; Region: PRK15000
243365011261	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
243365011262	dimer interface [polypeptide binding]; other site
243365011263	decamer (pentamer of dimers) interface [polypeptide binding]; other site
243365011264	catalytic triad [active]
243365011265	peroxidatic and resolving cysteines [active]
243365011266	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
243365011267	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
243365011268	dimer interface [polypeptide binding]; other site
243365011269	anticodon binding site; other site
243365011270	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
243365011271	homodimer interface [polypeptide binding]; other site
243365011272	motif 1; other site
243365011273	active site
243365011274	motif 2; other site
243365011275	GAD domain; Region: GAD; pfam02938
243365011276	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
243365011277	motif 3; other site
243365011278	Uncharacterized conserved protein [Function unknown]; Region: COG2928
243365011279	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
243365011280	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533
243365011281	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
243365011282	NAD binding site [chemical binding]; other site
243365011283	homotetramer interface [polypeptide binding]; other site
243365011284	homodimer interface [polypeptide binding]; other site
243365011285	substrate binding site [chemical binding]; other site
243365011286	active site
243365011287	phosphate acetyltransferase; Provisional; Region: PRK11890
243365011288	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
243365011289	propionate/acetate kinase; Provisional; Region: PRK12379
243365011290	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
243365011291	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
243365011292	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
243365011293	catalytic triad [active]
243365011294	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
243365011295	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
243365011296	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
243365011297	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
243365011298	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
243365011299	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
243365011300	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
243365011301	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
243365011302	active site
243365011303	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
243365011304	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
243365011305	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
243365011306	MOSC domain; Region: MOSC; pfam03473
243365011307	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
243365011308	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365011309	putative substrate translocation pore; other site
243365011310	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365011311	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
243365011312	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365011313	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
243365011314	dimerization interface [polypeptide binding]; other site
243365011315	diaminopimelate decarboxylase; Provisional; Region: PRK11165
243365011316	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
243365011317	active site
243365011318	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
243365011319	substrate binding site [chemical binding]; other site
243365011320	catalytic residues [active]
243365011321	dimer interface [polypeptide binding]; other site
243365011322	BON domain; Region: BON; pfam04972
243365011323	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
243365011324	MltA specific insert domain; Region: MltA; smart00925
243365011325	3D domain; Region: 3D; pfam06725
243365011326	Protein of unknown function (DUF1223); Region: DUF1223; pfam06764
243365011327	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
243365011328	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
243365011329	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
243365011330	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
243365011331	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
243365011332	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
243365011333	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
243365011334	DNA binding residues [nucleotide binding]
243365011335	DNA primase; Validated; Region: dnaG; PRK05667
243365011336	CHC2 zinc finger; Region: zf-CHC2; pfam01807
243365011337	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
243365011338	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
243365011339	active site
243365011340	metal binding site [ion binding]; metal-binding site
243365011341	interdomain interaction site; other site
243365011342	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
243365011343	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
243365011344	Yqey-like protein; Region: YqeY; pfam09424
243365011345	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
243365011346	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
243365011347	ThiS interaction site; other site
243365011348	putative active site [active]
243365011349	tetramer interface [polypeptide binding]; other site
243365011350	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
243365011351	thiS-thiF/thiG interaction site; other site
243365011352	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
243365011353	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
243365011354	Zn2+ binding site [ion binding]; other site
243365011355	Mg2+ binding site [ion binding]; other site
243365011356	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
243365011357	synthetase active site [active]
243365011358	NTP binding site [chemical binding]; other site
243365011359	metal binding site [ion binding]; metal-binding site
243365011360	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
243365011361	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
243365011362	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
243365011363	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
243365011364	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
243365011365	catalytic site [active]
243365011366	G-X2-G-X-G-K; other site
243365011367	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
243365011368	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
243365011369	active site
243365011370	Predicted membrane protein [Function unknown]; Region: COG4709
243365011371	Protein of unknown function (DUF1700); Region: DUF1700; pfam08006
243365011372	Predicted transcriptional regulators [Transcription]; Region: COG1695
243365011373	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
243365011374	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
243365011375	Patatin-like phospholipase; Region: Patatin; pfam01734
243365011376	active site
243365011377	nucleophile elbow; other site
243365011378	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
243365011379	hypothetical protein; Provisional; Region: PRK04286
243365011380	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
243365011381	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
243365011382	putative substrate binding site [chemical binding]; other site
243365011383	nucleotide binding site [chemical binding]; other site
243365011384	nucleotide binding site [chemical binding]; other site
243365011385	homodimer interface [polypeptide binding]; other site
243365011386	ornithine carbamoyltransferase; Validated; Region: PRK02102
243365011387	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
243365011388	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
243365011389	arginine deiminase; Provisional; Region: PRK01388
243365011390	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
243365011391	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
243365011392	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
243365011393	catalytic loop [active]
243365011394	iron binding site [ion binding]; other site
243365011395	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
243365011396	FAD binding pocket [chemical binding]; other site
243365011397	FAD binding motif [chemical binding]; other site
243365011398	phosphate binding motif [ion binding]; other site
243365011399	beta-alpha-beta structure motif; other site
243365011400	NAD binding pocket [chemical binding]; other site
243365011401	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
243365011402	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
243365011403	putative NAD(P) binding site [chemical binding]; other site
243365011404	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365011405	S-adenosylmethionine binding site [chemical binding]; other site
243365011406	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
243365011407	catalytic residues [active]
243365011408	dimer interface [polypeptide binding]; other site
243365011409	Domain of unknown function (DUF1841); Region: DUF1841; pfam08897
243365011410	glycerate dehydrogenase; Provisional; Region: PRK06487
243365011411	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
243365011412	putative ligand binding site [chemical binding]; other site
243365011413	putative NAD binding site [chemical binding]; other site
243365011414	catalytic site [active]
243365011415	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
243365011416	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
243365011417	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
243365011418	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
243365011419	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
243365011420	alanine racemase; Reviewed; Region: alr; PRK00053
243365011421	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
243365011422	active site
243365011423	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
243365011424	substrate binding site [chemical binding]; other site
243365011425	catalytic residues [active]
243365011426	dimer interface [polypeptide binding]; other site
243365011427	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
243365011428	generic binding surface I; other site
243365011429	generic binding surface II; other site
243365011430	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
243365011431	putative active site [active]
243365011432	putative catalytic site [active]
243365011433	putative Mg binding site IVb [ion binding]; other site
243365011434	putative DNA binding site [nucleotide binding]; other site
243365011435	putative phosphate binding site [ion binding]; other site
243365011436	putative Mg binding site IVa [ion binding]; other site
243365011437	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
243365011438	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
243365011439	active site
243365011440	substrate binding site [chemical binding]; other site
243365011441	metal binding site [ion binding]; metal-binding site
243365011442	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
243365011443	dihydropteroate synthase; Region: DHPS; TIGR01496
243365011444	substrate binding pocket [chemical binding]; other site
243365011445	dimer interface [polypeptide binding]; other site
243365011446	inhibitor binding site; inhibition site
243365011447	FtsH Extracellular; Region: FtsH_ext; pfam06480
243365011448	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
243365011449	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243365011450	Walker A motif; other site
243365011451	ATP binding site [chemical binding]; other site
243365011452	Walker B motif; other site
243365011453	arginine finger; other site
243365011454	Peptidase family M41; Region: Peptidase_M41; pfam01434
243365011455	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
243365011456	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365011457	S-adenosylmethionine binding site [chemical binding]; other site
243365011458	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
243365011459	Domain of unknown function (DUF4149); Region: DUF4149; pfam13664
243365011460	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
243365011461	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
243365011462	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
243365011463	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
243365011464	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
243365011465	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
243365011466	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
243365011467	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
243365011468	ATP-grasp domain; Region: ATP-grasp_4; cl17255
243365011469	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
243365011470	IMP binding site; other site
243365011471	dimer interface [polypeptide binding]; other site
243365011472	interdomain contacts; other site
243365011473	partial ornithine binding site; other site
243365011474	leucine export protein LeuE; Provisional; Region: PRK10958
243365011475	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
243365011476	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
243365011477	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
243365011478	catalytic site [active]
243365011479	subunit interface [polypeptide binding]; other site
243365011480	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
243365011481	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
243365011482	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
243365011483	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
243365011484	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
243365011485	type II secretion system protein J; Region: gspJ; TIGR01711
243365011486	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
243365011487	type II secretion system protein I; Region: gspI; TIGR01707
243365011488	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
243365011489	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
243365011490	Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963
243365011491	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
243365011492	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
243365011493	type II secretion system protein F; Region: GspF; TIGR02120
243365011494	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
243365011495	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
243365011496	type II secretion system protein E; Region: type_II_gspE; TIGR02533
243365011497	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
243365011498	Walker A motif; other site
243365011499	ATP binding site [chemical binding]; other site
243365011500	Walker B motif; other site
243365011501	type II secretion system protein D; Region: type_II_gspD; TIGR02517
243365011502	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
243365011503	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
243365011504	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
243365011505	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
243365011506	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
243365011507	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
243365011508	active site
243365011509	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
243365011510	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
243365011511	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
243365011512	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
243365011513	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
243365011514	Ligand binding site [chemical binding]; other site
243365011515	Electron transfer flavoprotein domain; Region: ETF; pfam01012
243365011516	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
243365011517	dimer interaction site [polypeptide binding]; other site
243365011518	substrate-binding tunnel; other site
243365011519	active site
243365011520	catalytic site [active]
243365011521	substrate binding site [chemical binding]; other site
243365011522	epoxyqueuosine reductase; Region: TIGR00276
243365011523	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
243365011524	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
243365011525	AMIN domain; Region: AMIN; pfam11741
243365011526	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
243365011527	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
243365011528	active site
243365011529	metal binding site [ion binding]; metal-binding site
243365011530	Domain of unknown function (DUF329); Region: DUF329; pfam03884
243365011531	hypothetical protein; Provisional; Region: PRK05287
243365011532	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
243365011533	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
243365011534	CoA-binding site [chemical binding]; other site
243365011535	ATP-binding [chemical binding]; other site
243365011536	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
243365011537	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
243365011538	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
243365011539	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
243365011540	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
243365011541	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
243365011542	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
243365011543	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
243365011544	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
243365011545	Walker A motif; other site
243365011546	ATP binding site [chemical binding]; other site
243365011547	Walker B motif; other site
243365011548	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
243365011549	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
243365011550	trimer interface [polypeptide binding]; other site
243365011551	eyelet of channel; other site
243365011552	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
243365011553	Helix-hairpin-helix motif; Region: HHH; pfam00633
243365011554	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
243365011555	signal recognition particle protein; Provisional; Region: PRK10867
243365011556	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
243365011557	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
243365011558	P loop; other site
243365011559	GTP binding site [chemical binding]; other site
243365011560	Signal peptide binding domain; Region: SRP_SPB; pfam02978
243365011561	adenylosuccinate lyase; Provisional; Region: PRK09285
243365011562	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
243365011563	tetramer interface [polypeptide binding]; other site
243365011564	active site
243365011565	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
243365011566	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
243365011567	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
243365011568	E3 interaction surface; other site
243365011569	lipoyl attachment site [posttranslational modification]; other site
243365011570	HlyD family secretion protein; Region: HlyD_3; pfam13437
243365011571	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
243365011572	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
243365011573	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
243365011574	[4Fe-4S] binding site [ion binding]; other site
243365011575	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
243365011576	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
243365011577	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
243365011578	molybdopterin cofactor binding site; other site
243365011579	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
243365011580	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
243365011581	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
243365011582	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
243365011583	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
243365011584	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
243365011585	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
243365011586	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365011587	active site
243365011588	phosphorylation site [posttranslational modification]
243365011589	intermolecular recognition site; other site
243365011590	dimerization interface [polypeptide binding]; other site
243365011591	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
243365011592	DNA binding site [nucleotide binding]
243365011593	sensor protein RstB; Provisional; Region: PRK10604
243365011594	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
243365011595	dimerization interface [polypeptide binding]; other site
243365011596	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365011597	ATP binding site [chemical binding]; other site
243365011598	Mg2+ binding site [ion binding]; other site
243365011599	G-X-G motif; other site
243365011600	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
243365011601	ribonuclease PH; Reviewed; Region: rph; PRK00173
243365011602	Ribonuclease PH; Region: RNase_PH_bact; cd11362
243365011603	hexamer interface [polypeptide binding]; other site
243365011604	active site
243365011605	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
243365011606	active site
243365011607	Catalytic domain of Protein Kinases; Region: PKc; cd00180
243365011608	Protein kinase domain; Region: Pkinase; pfam00069
243365011609	active site
243365011610	ATP binding site [chemical binding]; other site
243365011611	substrate binding site [chemical binding]; other site
243365011612	activation loop (A-loop); other site
243365011613	hypothetical protein; Provisional; Region: PRK11820
243365011614	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
243365011615	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
243365011616	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
243365011617	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
243365011618	active site
243365011619	Int/Topo IB signature motif; other site
243365011620	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
243365011621	Domain of unknown function (DUF927); Region: DUF927; pfam06048
243365011622	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
243365011623	DNA binding residues [nucleotide binding]
243365011624	B12 binding domain; Region: B12-binding; pfam02310
243365011625	B12 binding site [chemical binding]; other site
243365011626	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
243365011627	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243365011628	FeS/SAM binding site; other site
243365011629	Tetratricopeptide repeat; Region: TPR_16; pfam13432
243365011630	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
243365011631	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
243365011632	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243365011633	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365011634	dimer interface [polypeptide binding]; other site
243365011635	putative CheW interface [polypeptide binding]; other site
243365011636	Protein of unknown function (DUF3761); Region: DUF3761; pfam12587
243365011637	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
243365011638	IHF dimer interface [polypeptide binding]; other site
243365011639	IHF - DNA interface [nucleotide binding]; other site
243365011640	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
243365011641	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
243365011642	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
243365011643	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
243365011644	Protein of unknown function (DUF2802); Region: DUF2802; pfam10975
243365011645	Flagellar protein FliS; Region: FliS; cl00654
243365011646	Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345
243365011647	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
243365011648	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
243365011649	FlaG protein; Region: FlaG; pfam03646
243365011650	flagellin; Provisional; Region: PRK12802
243365011651	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
243365011652	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
243365011653	flagellin; Provisional; Region: PRK12802
243365011654	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
243365011655	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
243365011656	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
243365011657	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
243365011658	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
243365011659	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
243365011660	active site
243365011661	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
243365011662	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
243365011663	Probable Catalytic site; other site
243365011664	metal-binding site
243365011665	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
243365011666	B12 binding domain; Region: B12-binding; pfam02310
243365011667	B12 binding site [chemical binding]; other site
243365011668	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243365011669	Radical SAM superfamily; Region: Radical_SAM; pfam04055
243365011670	FeS/SAM binding site; other site
243365011671	TPR repeat; Region: TPR_11; pfam13414
243365011672	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243365011673	TPR motif; other site
243365011674	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
243365011675	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
243365011676	active site
243365011677	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
243365011678	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
243365011679	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243365011680	NAD(P) binding site [chemical binding]; other site
243365011681	active site
243365011682	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243365011683	FeS/SAM binding site; other site
243365011684	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
243365011685	nudix motif; other site
243365011686	Methyltransferase domain; Region: Methyltransf_23; pfam13489
243365011687	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
243365011688	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
243365011689	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
243365011690	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
243365011691	dimer interface [polypeptide binding]; other site
243365011692	PYR/PP interface [polypeptide binding]; other site
243365011693	TPP binding site [chemical binding]; other site
243365011694	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
243365011695	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
243365011696	TPP-binding site [chemical binding]; other site
243365011697	Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089
243365011698	NeuB family; Region: NeuB; pfam03102
243365011699	Domains similar to fish antifreeze type III protein; Region: SAF; cd11611
243365011700	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
243365011701	lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407
243365011702	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
243365011703	inhibitor-cofactor binding pocket; inhibition site
243365011704	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365011705	catalytic residue [active]
243365011706	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
243365011707	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
243365011708	NAD binding site [chemical binding]; other site
243365011709	homotetramer interface [polypeptide binding]; other site
243365011710	homodimer interface [polypeptide binding]; other site
243365011711	substrate binding site [chemical binding]; other site
243365011712	active site
243365011713	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
243365011714	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
243365011715	substrate binding site; other site
243365011716	5'-methylthioadenosine phosphorylase; Validated; Region: PRK09136
243365011717	Hemin uptake protein hemP; Region: hemP; pfam10636
243365011718	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
243365011719	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
243365011720	N-terminal plug; other site
243365011721	ligand-binding site [chemical binding]; other site
243365011722	Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720
243365011723	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
243365011724	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
243365011725	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
243365011726	dimer interface [polypeptide binding]; other site
243365011727	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
243365011728	putative PBP binding regions; other site
243365011729	ABC-ATPase subunit  interface; other site
243365011730	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
243365011731	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
243365011732	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
243365011733	active site
243365011734	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
243365011735	active site
243365011736	tetramer interface; other site
243365011737	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243365011738	TPR repeat; Region: TPR_11; pfam13414
243365011739	binding surface
243365011740	TPR motif; other site
243365011741	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243365011742	binding surface
243365011743	TPR motif; other site
243365011744	Tetratricopeptide repeat; Region: TPR_12; pfam13424
243365011745	ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782
243365011746	Ligase N family; Region: LIGANc; smart00532
243365011747	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
243365011748	nucleotide binding pocket [chemical binding]; other site
243365011749	K-X-D-G motif; other site
243365011750	catalytic site [active]
243365011751	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
243365011752	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
243365011753	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
243365011754	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
243365011755	Dimer interface [polypeptide binding]; other site
243365011756	BRCT sequence motif; other site
243365011757	ZipA, C-terminal domain (FtsZ-binding); Region: ZipA_C; smart00771
243365011758	FtsZ protein binding site [polypeptide binding]; other site
243365011759	Transcriptional regulators [Transcription]; Region: MarR; COG1846
243365011760	MarR family; Region: MarR; pfam01047
243365011761	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
243365011762	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
243365011763	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
243365011764	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
243365011765	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
243365011766	Walker A/P-loop; other site
243365011767	ATP binding site [chemical binding]; other site
243365011768	Q-loop/lid; other site
243365011769	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
243365011770	ABC transporter signature motif; other site
243365011771	Walker B; other site
243365011772	D-loop; other site
243365011773	H-loop/switch region; other site
243365011774	hypothetical protein; Validated; Region: PRK00228
243365011775	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
243365011776	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
243365011777	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
243365011778	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
243365011779	GTP/Mg2+ binding site [chemical binding]; other site
243365011780	G4 box; other site
243365011781	G5 box; other site
243365011782	G1 box; other site
243365011783	Switch I region; other site
243365011784	G2 box; other site
243365011785	G3 box; other site
243365011786	Switch II region; other site
243365011787	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
243365011788	Predicted membrane protein [Function unknown]; Region: COG3671
243365011789	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
243365011790	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
243365011791	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
243365011792	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
243365011793	CoA-transferase family III; Region: CoA_transf_3; pfam02515
243365011794	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
243365011795	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
243365011796	FAD binding site [chemical binding]; other site
243365011797	substrate binding pocket [chemical binding]; other site
243365011798	catalytic base [active]
243365011799	Transcriptional regulator [Transcription]; Region: IclR; COG1414
243365011800	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
243365011801	Bacterial transcriptional regulator; Region: IclR; pfam01614
243365011802	FOG: CBS domain [General function prediction only]; Region: COG0517
243365011803	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
243365011804	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
243365011805	feedback inhibition sensing region; other site
243365011806	homohexameric interface [polypeptide binding]; other site
243365011807	nucleotide binding site [chemical binding]; other site
243365011808	N-acetyl-L-glutamate binding site [chemical binding]; other site
243365011809	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243365011810	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
243365011811	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
243365011812	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
243365011813	HlyD family secretion protein; Region: HlyD_3; pfam13437
243365011814	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
243365011815	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
243365011816	4-aminobutyrate aminotransferase; Provisional; Region: PRK07495
243365011817	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
243365011818	inhibitor-cofactor binding pocket; inhibition site
243365011819	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365011820	catalytic residue [active]
243365011821	succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241
243365011822	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
243365011823	tetramerization interface [polypeptide binding]; other site
243365011824	NAD(P) binding site [chemical binding]; other site
243365011825	catalytic residues [active]
243365011826	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
243365011827	L-aspartate oxidase; Provisional; Region: PRK09077
243365011828	L-aspartate oxidase; Provisional; Region: PRK06175
243365011829	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
243365011830	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
243365011831	aromatic chitin/cellulose binding site residues [chemical binding]; other site
243365011832	Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978
243365011833	chitosan binding site [chemical binding]; other site
243365011834	catalytic residues [active]
243365011835	Protein of unknown function, DUF; Region: DUF411; cl01142
243365011836	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
243365011837	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
243365011838	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
243365011839	peptide binding site [polypeptide binding]; other site
243365011840	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
243365011841	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA) subfamily; Region: M14_ASTE_ASPA_like; cd06230
243365011842	active site
243365011843	Zn binding site [ion binding]; other site
243365011844	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
243365011845	FtsX-like permease family; Region: FtsX; pfam02687
243365011846	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
243365011847	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
243365011848	Walker A/P-loop; other site
243365011849	ATP binding site [chemical binding]; other site
243365011850	Q-loop/lid; other site
243365011851	ABC transporter signature motif; other site
243365011852	Walker B; other site
243365011853	D-loop; other site
243365011854	H-loop/switch region; other site
243365011855	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
243365011856	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
243365011857	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
243365011858	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
243365011859	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
243365011860	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
243365011861	active site
243365011862	FMN binding site [chemical binding]; other site
243365011863	2,4-decadienoyl-CoA binding site; other site
243365011864	catalytic residue [active]
243365011865	4Fe-4S cluster binding site [ion binding]; other site
243365011866	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243365011867	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
243365011868	NAD(P) binding site [chemical binding]; other site
243365011869	active site
243365011870	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
243365011871	active site
243365011872	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
243365011873	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
243365011874	dimer interface [polypeptide binding]; other site
243365011875	active site
243365011876	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
243365011877	active site 2 [active]
243365011878	active site 1 [active]
243365011879	Trm112p-like protein; Region: Trm112p; pfam03966
243365011880	Methyltransferase domain; Region: Methyltransf_31; pfam13847
243365011881	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365011882	S-adenosylmethionine binding site [chemical binding]; other site
243365011883	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
243365011884	putative NAD(P) binding site [chemical binding]; other site
243365011885	active site
243365011886	putative substrate binding site [chemical binding]; other site
243365011887	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
243365011888	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
243365011889	substrate binding pocket [chemical binding]; other site
243365011890	substrate-Mg2+ binding site; other site
243365011891	aspartate-rich region 1; other site
243365011892	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
243365011893	aspartate-rich region 2; other site
243365011894	UbiA prenyltransferase family; Region: UbiA; pfam01040
243365011895	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
243365011896	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
243365011897	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243365011898	active site
243365011899	motif I; other site
243365011900	motif II; other site
243365011901	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243365011902	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
243365011903	substrate binding pocket [chemical binding]; other site
243365011904	substrate-Mg2+ binding site; other site
243365011905	aspartate-rich region 1; other site
243365011906	aspartate-rich region 2; other site
243365011907	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
243365011908	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
243365011909	active site
243365011910	dimer interface [polypeptide binding]; other site
243365011911	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
243365011912	Ligand Binding Site [chemical binding]; other site
243365011913	Molecular Tunnel; other site
243365011914	AAK_FomA-like: This CD includes a fosfomycin biosynthetic gene product, FomA, and similar proteins found in a wide range of organisms. Together, the fomA and fomB genes in the fosfomycin biosynthetic gene cluster of Streptomyces wedmorensis confer...; Region: AAK_FomA-like; cd04241
243365011915	putative nucleotide binding site [chemical binding]; other site
243365011916	putative substrate binding site [chemical binding]; other site
243365011917	hypothetical protein; Provisional; Region: PRK02227
243365011918	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
243365011919	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
243365011920	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
243365011921	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243365011922	Walker A motif; other site
243365011923	ATP binding site [chemical binding]; other site
243365011924	Walker B motif; other site
243365011925	arginine finger; other site
243365011926	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243365011927	Walker A motif; other site
243365011928	ATP binding site [chemical binding]; other site
243365011929	Walker B motif; other site
243365011930	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
243365011931	type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347
243365011932	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
243365011933	type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359
243365011934	Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480
243365011935	Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480
243365011936	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
243365011937	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
243365011938	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
243365011939	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
243365011940	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
243365011941	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
243365011942	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
243365011943	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
243365011944	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
243365011945	ligand binding site [chemical binding]; other site
243365011946	Protein of unknown function (DUF796); Region: DUF796; pfam05638
243365011947	type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355
243365011948	Protein of unknown function (DUF877); Region: DUF877; pfam05943
243365011949	Protein of unknown function (DUF770); Region: DUF770; pfam05591
243365011950	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
243365011951	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
243365011952	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
243365011953	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
243365011954	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
243365011955	Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790
243365011956	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
243365011957	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
243365011958	type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349
243365011959	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
243365011960	Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501
243365011961	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
243365011962	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
243365011963	Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296
243365011964	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106
243365011965	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
243365011966	Protein of unknown function (DUF3304); Region: DUF3304; pfam11745
243365011967	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
243365011968	protoheme IX farnesyltransferase; Provisional; Region: PRK13362
243365011969	UbiA prenyltransferase family; Region: UbiA; pfam01040
243365011970	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
243365011971	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
243365011972	Subunit I/III interface [polypeptide binding]; other site
243365011973	Subunit III/IV interface [polypeptide binding]; other site
243365011974	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
243365011975	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
243365011976	D-pathway; other site
243365011977	Putative ubiquinol binding site [chemical binding]; other site
243365011978	Low-spin heme (heme b) binding site [chemical binding]; other site
243365011979	Putative water exit pathway; other site
243365011980	Binuclear center (heme o3/CuB) [ion binding]; other site
243365011981	K-pathway; other site
243365011982	Putative proton exit pathway; other site
243365011983	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
243365011984	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
243365011985	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
243365011986	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
243365011987	catalytic residues [active]
243365011988	hinge region; other site
243365011989	alpha helical domain; other site
243365011990	Sporulation related domain; Region: SPOR; pfam05036
243365011991	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
243365011992	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
243365011993	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
243365011994	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
243365011995	Membrane fusogenic activity; Region: BMFP; pfam04380
243365011996	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
243365011997	Nitrogen regulatory protein P-II; Region: P-II; smart00938
243365011998	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
243365011999	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
243365012000	stringent starvation protein A; Provisional; Region: sspA; PRK09481
243365012001	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
243365012002	C-terminal domain interface [polypeptide binding]; other site
243365012003	putative GSH binding site (G-site) [chemical binding]; other site
243365012004	dimer interface [polypeptide binding]; other site
243365012005	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
243365012006	dimer interface [polypeptide binding]; other site
243365012007	N-terminal domain interface [polypeptide binding]; other site
243365012008	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
243365012009	Cytochrome c; Region: Cytochrom_C; cl11414
243365012010	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
243365012011	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
243365012012	intrachain domain interface; other site
243365012013	interchain domain interface [polypeptide binding]; other site
243365012014	heme bH binding site [chemical binding]; other site
243365012015	heme bL binding site [chemical binding]; other site
243365012016	Qo binding site; other site
243365012017	interchain domain interface [polypeptide binding]; other site
243365012018	intrachain domain interface; other site
243365012019	Qi binding site; other site
243365012020	Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032
243365012021	Qo binding site; other site
243365012022	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
243365012023	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
243365012024	[2Fe-2S] cluster binding site [ion binding]; other site
243365012025	Uncharacterized conserved protein [Function unknown]; Region: COG0327
243365012026	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
243365012027	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
243365012028	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
243365012029	NAD binding site [chemical binding]; other site
243365012030	substrate binding site [chemical binding]; other site
243365012031	homodimer interface [polypeptide binding]; other site
243365012032	active site
243365012033	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
243365012034	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
243365012035	NADP binding site [chemical binding]; other site
243365012036	active site
243365012037	putative substrate binding site [chemical binding]; other site
243365012038	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
243365012039	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
243365012040	substrate binding site; other site
243365012041	tetramer interface; other site
243365012042	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
243365012043	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
243365012044	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
243365012045	ring oligomerisation interface [polypeptide binding]; other site
243365012046	ATP/Mg binding site [chemical binding]; other site
243365012047	stacking interactions; other site
243365012048	hinge regions; other site
243365012049	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
243365012050	oligomerisation interface [polypeptide binding]; other site
243365012051	mobile loop; other site
243365012052	roof hairpin; other site
243365012053	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
243365012054	This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912
243365012055	Mg++ binding site [ion binding]; other site
243365012056	putative catalytic motif [active]
243365012057	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
243365012058	UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721
243365012059	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
243365012060	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
243365012061	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
243365012062	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
243365012063	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
243365012064	active site
243365012065	homodimer interface [polypeptide binding]; other site
243365012066	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
243365012067	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
243365012068	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u8; cd10932
243365012069	NodB motif; other site
243365012070	putative active site [active]
243365012071	putative catalytic site [active]
243365012072	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
243365012073	phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308
243365012074	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
243365012075	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
243365012076	trimer interface [polypeptide binding]; other site
243365012077	active site
243365012078	substrate binding site [chemical binding]; other site
243365012079	CoA binding site [chemical binding]; other site
243365012080	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
243365012081	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
243365012082	ligand binding site; other site
243365012083	tetramer interface; other site
243365012084	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
243365012085	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607
243365012086	FOG: CBS domain [General function prediction only]; Region: COG0517
243365012087	NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426
243365012088	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
243365012089	Substrate binding site; other site
243365012090	metal-binding site
243365012091	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
243365012092	NeuB family; Region: NeuB; pfam03102
243365012093	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
243365012094	NeuB binding interface [polypeptide binding]; other site
243365012095	putative substrate binding site [chemical binding]; other site
243365012096	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
243365012097	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
243365012098	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
243365012099	catalytic residue [active]
243365012100	UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568
243365012101	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
243365012102	active site
243365012103	homodimer interface [polypeptide binding]; other site
243365012104	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
243365012105	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
243365012106	inhibitor-cofactor binding pocket; inhibition site
243365012107	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365012108	catalytic residue [active]
243365012109	NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180
243365012110	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
243365012111	NAD binding site [chemical binding]; other site
243365012112	substrate binding site [chemical binding]; other site
243365012113	active site
243365012114	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
243365012115	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
243365012116	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
243365012117	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
243365012118	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
243365012119	active site
243365012120	dimer interface [polypeptide binding]; other site
243365012121	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
243365012122	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
243365012123	active site
243365012124	FMN binding site [chemical binding]; other site
243365012125	substrate binding site [chemical binding]; other site
243365012126	3Fe-4S cluster binding site [ion binding]; other site
243365012127	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
243365012128	domain interface; other site
243365012129	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
243365012130	putative active site [active]
243365012131	catalytic site [active]
243365012132	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
243365012133	putative active site [active]
243365012134	catalytic site [active]
243365012135	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
243365012136	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
243365012137	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
243365012138	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
243365012139	catalytic residue [active]
243365012140	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
243365012141	PAS fold; Region: PAS_7; pfam12860
243365012142	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365012143	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365012144	metal binding site [ion binding]; metal-binding site
243365012145	active site
243365012146	I-site; other site
243365012147	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
243365012148	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
243365012149	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
243365012150	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
243365012151	ferredoxin-NADP reductase; Provisional; Region: PRK10926
243365012152	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
243365012153	FAD binding pocket [chemical binding]; other site
243365012154	FAD binding motif [chemical binding]; other site
243365012155	phosphate binding motif [ion binding]; other site
243365012156	beta-alpha-beta structure motif; other site
243365012157	NAD binding pocket [chemical binding]; other site
243365012158	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
243365012159	catalytic nucleophile [active]
243365012160	Nitronate monooxygenase; Region: NMO; pfam03060
243365012161	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
243365012162	FMN binding site [chemical binding]; other site
243365012163	substrate binding site [chemical binding]; other site
243365012164	putative catalytic residue [active]
243365012165	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
243365012166	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
243365012167	homodimer interface [polypeptide binding]; other site
243365012168	substrate-cofactor binding pocket; other site
243365012169	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365012170	catalytic residue [active]
243365012171	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
243365012172	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
243365012173	acyl-activating enzyme (AAE) consensus motif; other site
243365012174	putative AMP binding site [chemical binding]; other site
243365012175	putative active site [active]
243365012176	putative CoA binding site [chemical binding]; other site
243365012177	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365012178	dimer interface [polypeptide binding]; other site
243365012179	conserved gate region; other site
243365012180	putative PBP binding loops; other site
243365012181	ABC-ATPase subunit interface; other site
243365012182	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243365012183	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243365012184	substrate binding pocket [chemical binding]; other site
243365012185	membrane-bound complex binding site; other site
243365012186	hinge residues; other site
243365012187	Chain length determinant protein; Region: Wzz; cl15801
243365012188	GTP-binding protein YchF; Reviewed; Region: PRK09601
243365012189	YchF GTPase; Region: YchF; cd01900
243365012190	G1 box; other site
243365012191	GTP/Mg2+ binding site [chemical binding]; other site
243365012192	Switch I region; other site
243365012193	G2 box; other site
243365012194	Switch II region; other site
243365012195	G3 box; other site
243365012196	G4 box; other site
243365012197	G5 box; other site
243365012198	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
243365012199	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
243365012200	putative active site [active]
243365012201	catalytic residue [active]
243365012202	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
243365012203	5S rRNA interface [nucleotide binding]; other site
243365012204	CTC domain interface [polypeptide binding]; other site
243365012205	L16 interface [polypeptide binding]; other site
243365012206	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
243365012207	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
243365012208	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
243365012209	active site
243365012210	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
243365012211	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
243365012212	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
243365012213	outer membrane lipoprotein LolB; Region: lolB; TIGR00548
243365012214	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
243365012215	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243365012216	binding surface
243365012217	TPR motif; other site
243365012218	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243365012219	binding surface
243365012220	TPR motif; other site
243365012221	TPR repeat; Region: TPR_11; pfam13414
243365012222	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
243365012223	binding surface
243365012224	TPR motif; other site
243365012225	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
243365012226	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
243365012227	DNA binding site [nucleotide binding]
243365012228	catalytic residue [active]
243365012229	H2TH interface [polypeptide binding]; other site
243365012230	putative catalytic residues [active]
243365012231	turnover-facilitating residue; other site
243365012232	intercalation triad [nucleotide binding]; other site
243365012233	8OG recognition residue [nucleotide binding]; other site
243365012234	putative reading head residues; other site
243365012235	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
243365012236	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
243365012237	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
243365012238	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
243365012239	putative acyl-acceptor binding pocket; other site
243365012240	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
243365012241	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cl00541
243365012242	SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825
243365012243	active site
243365012244	oxyanion hole [active]
243365012245	catalytic triad [active]
243365012246	SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829
243365012247	active site
243365012248	catalytic triad [active]
243365012249	oxyanion hole [active]
243365012250	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
243365012251	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
243365012252	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
243365012253	active site
243365012254	metal binding site [ion binding]; metal-binding site
243365012255	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
243365012256	Part of AAA domain; Region: AAA_19; pfam13245
243365012257	Family description; Region: UvrD_C_2; pfam13538
243365012258	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
243365012259	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
243365012260	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
243365012261	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
243365012262	Walker A/P-loop; other site
243365012263	ATP binding site [chemical binding]; other site
243365012264	Q-loop/lid; other site
243365012265	ABC transporter signature motif; other site
243365012266	Walker B; other site
243365012267	D-loop; other site
243365012268	H-loop/switch region; other site
243365012269	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_hydrolase_3; cd03676
243365012270	nudix motif; other site
243365012271	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
243365012272	AAA domain; Region: AAA_30; pfam13604
243365012273	Family description; Region: UvrD_C_2; pfam13538
243365012274	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
243365012275	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
243365012276	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
243365012277	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
243365012278	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
243365012279	Family description; Region: UvrD_C_2; pfam13538
243365012280	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
243365012281	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
243365012282	Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247
243365012283	Protein of unknown function (DUF342); Region: DUF342; pfam03961
243365012284	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
243365012285	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
243365012286	Peptidase family U32; Region: Peptidase_U32; pfam01136
243365012287	putative protease; Provisional; Region: PRK15447
243365012288	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
243365012289	SCP-2 sterol transfer family; Region: SCP2; cl01225
243365012290	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365012291	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365012292	metal binding site [ion binding]; metal-binding site
243365012293	active site
243365012294	I-site; other site
243365012295	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365012296	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365012297	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
243365012298	putative effector binding pocket; other site
243365012299	dimerization interface [polypeptide binding]; other site
243365012300	Autoinducer binding domain; Region: Autoind_bind; pfam03472
243365012301	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
243365012302	DNA binding residues [nucleotide binding]
243365012303	dimerization interface [polypeptide binding]; other site
243365012304	Autoinducer synthetase; Region: Autoind_synth; cl17404
243365012305	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
243365012306	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
243365012307	NAD(P) binding site [chemical binding]; other site
243365012308	catalytic residues [active]
243365012309	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
243365012310	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
243365012311	Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521
243365012312	active site residue [active]
243365012313	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
243365012314	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
243365012315	DNA-binding site [nucleotide binding]; DNA binding site
243365012316	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
243365012317	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365012318	homodimer interface [polypeptide binding]; other site
243365012319	catalytic residue [active]
243365012320	Uncharacterized conserved protein [Function unknown]; Region: COG1683
243365012321	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
243365012322	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
243365012323	motif II; other site
243365012324	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
243365012325	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
243365012326	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
243365012327	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365012328	dimer interface [polypeptide binding]; other site
243365012329	conserved gate region; other site
243365012330	putative PBP binding loops; other site
243365012331	ABC-ATPase subunit interface; other site
243365012332	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
243365012333	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365012334	dimer interface [polypeptide binding]; other site
243365012335	conserved gate region; other site
243365012336	putative PBP binding loops; other site
243365012337	ABC-ATPase subunit interface; other site
243365012338	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
243365012339	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243365012340	Walker A/P-loop; other site
243365012341	ATP binding site [chemical binding]; other site
243365012342	Q-loop/lid; other site
243365012343	ABC transporter signature motif; other site
243365012344	Walker B; other site
243365012345	D-loop; other site
243365012346	H-loop/switch region; other site
243365012347	TOBE domain; Region: TOBE_2; pfam08402
243365012348	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
243365012349	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
243365012350	HutD; Region: HutD; pfam05962
243365012351	Peptidase M30; Region: Peptidase_M30; pfam10460
243365012352	Protein with unknown function (DUF469); Region: DUF469; pfam04320
243365012353	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
243365012354	Uncharacterized conserved protein [Function unknown]; Region: COG1434
243365012355	putative active site [active]
243365012356	Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932
243365012357	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
243365012358	Aspartase; Region: Aspartase; cd01357
243365012359	active sites [active]
243365012360	tetramer interface [polypeptide binding]; other site
243365012361	cell density-dependent motility repressor; Provisional; Region: PRK10082
243365012362	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365012363	LysR substrate binding domain; Region: LysR_substrate; pfam03466
243365012364	dimerization interface [polypeptide binding]; other site
243365012365	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
243365012366	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
243365012367	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
243365012368	NAD(P) binding site [chemical binding]; other site
243365012369	homodimer interface [polypeptide binding]; other site
243365012370	substrate binding site [chemical binding]; other site
243365012371	active site
243365012372	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
243365012373	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365012374	Coenzyme A binding pocket [chemical binding]; other site
243365012375	Bacterial sugar transferase; Region: Bac_transf; pfam02397
243365012376	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
243365012377	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
243365012378	inhibitor-cofactor binding pocket; inhibition site
243365012379	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365012380	catalytic residue [active]
243365012381	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
243365012382	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
243365012383	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
243365012384	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
243365012385	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
243365012386	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
243365012387	trimer interface [polypeptide binding]; other site
243365012388	active site
243365012389	substrate binding site [chemical binding]; other site
243365012390	CoA binding site [chemical binding]; other site
243365012391	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
243365012392	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
243365012393	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
243365012394	inhibitor-cofactor binding pocket; inhibition site
243365012395	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365012396	catalytic residue [active]
243365012397	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
243365012398	putative trimer interface [polypeptide binding]; other site
243365012399	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
243365012400	putative CoA binding site [chemical binding]; other site
243365012401	putative trimer interface [polypeptide binding]; other site
243365012402	putative active site [active]
243365012403	putative substrate binding site [chemical binding]; other site
243365012404	putative CoA binding site [chemical binding]; other site
243365012405	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
243365012406	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
243365012407	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
243365012408	Uncharacterized conserved protein [Function unknown]; Region: COG1434
243365012409	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
243365012410	putative active site [active]
243365012411	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
243365012412	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
243365012413	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
243365012414	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365012415	S-adenosylmethionine binding site [chemical binding]; other site
243365012416	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
243365012417	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
243365012418	Ligand Binding Site [chemical binding]; other site
243365012419	pteridine reductase; Provisional; Region: PRK09135
243365012420	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
243365012421	NAD(P) binding site [chemical binding]; other site
243365012422	active site
243365012423	Uncharacterized conserved protein [Function unknown]; Region: COG1565
243365012424	Methyltransferase domain; Region: Methyltransf_18; pfam12847
243365012425	HAMP domain; Region: HAMP; pfam00672
243365012426	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365012427	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365012428	metal binding site [ion binding]; metal-binding site
243365012429	active site
243365012430	I-site; other site
243365012431	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
243365012432	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
243365012433	active site
243365012434	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
243365012435	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
243365012436	putative sugar binding sites [chemical binding]; other site
243365012437	Q-X-W motif; other site
243365012438	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
243365012439	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
243365012440	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
243365012441	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
243365012442	DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449
243365012443	HypX protein, N-terminal hydrolase domain; Region: FMT_core_HypX_N; cd08650
243365012444	putative active site [active]
243365012445	putative substrate binding site [chemical binding]; other site
243365012446	putative cosubstrate binding site; other site
243365012447	catalytic site [active]
243365012448	C-terminal subdomain of the Formyltransferase-like domain found in HypX-like proteins; Region: FMT_C_HypX; cd08701
243365012449	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
243365012450	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
243365012451	substrate binding site [chemical binding]; other site
243365012452	oxyanion hole (OAH) forming residues; other site
243365012453	trimer interface [polypeptide binding]; other site
243365012454	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365012455	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365012456	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
243365012457	dimerization interface [polypeptide binding]; other site
243365012458	StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804
243365012459	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
243365012460	EamA-like transporter family; Region: EamA; pfam00892
243365012461	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
243365012462	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
243365012463	RNA binding surface [nucleotide binding]; other site
243365012464	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
243365012465	active site
243365012466	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
243365012467	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
243365012468	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
243365012469	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
243365012470	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243365012471	FeS/SAM binding site; other site
243365012472	TRAM domain; Region: TRAM; pfam01938
243365012473	YCII-related domain; Region: YCII; cl00999
243365012474	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
243365012475	PhoH-like protein; Region: PhoH; pfam02562
243365012476	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
243365012477	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
243365012478	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
243365012479	Transporter associated domain; Region: CorC_HlyC; smart01091
243365012480	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
243365012481	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
243365012482	putative active site [active]
243365012483	catalytic triad [active]
243365012484	putative dimer interface [polypeptide binding]; other site
243365012485	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
243365012486	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243365012487	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365012488	dimer interface [polypeptide binding]; other site
243365012489	putative CheW interface [polypeptide binding]; other site
243365012490	Cache domain; Region: Cache_1; pfam02743
243365012491	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243365012492	dimerization interface [polypeptide binding]; other site
243365012493	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243365012494	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365012495	dimer interface [polypeptide binding]; other site
243365012496	putative CheW interface [polypeptide binding]; other site
243365012497	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
243365012498	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
243365012499	MOSC domain; Region: MOSC; pfam03473
243365012500	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
243365012501	glutaminase; Provisional; Region: PRK00971
243365012502	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
243365012503	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
243365012504	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
243365012505	alphaNTD homodimer interface [polypeptide binding]; other site
243365012506	alphaNTD - beta interaction site [polypeptide binding]; other site
243365012507	alphaNTD - beta' interaction site [polypeptide binding]; other site
243365012508	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
243365012509	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
243365012510	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
243365012511	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
243365012512	RNA binding surface [nucleotide binding]; other site
243365012513	30S ribosomal protein S11; Validated; Region: PRK05309
243365012514	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
243365012515	30S ribosomal protein S13; Region: bact_S13; TIGR03631
243365012516	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
243365012517	rRNA binding site [nucleotide binding]; other site
243365012518	predicted 30S ribosome binding site; other site
243365012519	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
243365012520	SecY translocase; Region: SecY; pfam00344
243365012521	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
243365012522	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
243365012523	23S rRNA binding site [nucleotide binding]; other site
243365012524	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
243365012525	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
243365012526	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
243365012527	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
243365012528	5S rRNA interface [nucleotide binding]; other site
243365012529	23S rRNA interface [nucleotide binding]; other site
243365012530	L5 interface [polypeptide binding]; other site
243365012531	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
243365012532	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
243365012533	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
243365012534	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
243365012535	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
243365012536	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
243365012537	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
243365012538	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
243365012539	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
243365012540	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
243365012541	RNA binding site [nucleotide binding]; other site
243365012542	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
243365012543	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
243365012544	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
243365012545	23S rRNA interface [nucleotide binding]; other site
243365012546	putative translocon interaction site; other site
243365012547	signal recognition particle (SRP54) interaction site; other site
243365012548	L23 interface [polypeptide binding]; other site
243365012549	trigger factor interaction site; other site
243365012550	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
243365012551	23S rRNA interface [nucleotide binding]; other site
243365012552	5S rRNA interface [nucleotide binding]; other site
243365012553	putative antibiotic binding site [chemical binding]; other site
243365012554	L25 interface [polypeptide binding]; other site
243365012555	L27 interface [polypeptide binding]; other site
243365012556	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
243365012557	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
243365012558	G-X-X-G motif; other site
243365012559	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
243365012560	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
243365012561	putative translocon binding site; other site
243365012562	protein-rRNA interface [nucleotide binding]; other site
243365012563	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
243365012564	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
243365012565	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
243365012566	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
243365012567	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
243365012568	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
243365012569	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
243365012570	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
243365012571	elongation factor Tu; Reviewed; Region: PRK00049
243365012572	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
243365012573	G1 box; other site
243365012574	GEF interaction site [polypeptide binding]; other site
243365012575	GTP/Mg2+ binding site [chemical binding]; other site
243365012576	Switch I region; other site
243365012577	G2 box; other site
243365012578	G3 box; other site
243365012579	Switch II region; other site
243365012580	G4 box; other site
243365012581	G5 box; other site
243365012582	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
243365012583	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
243365012584	Antibiotic Binding Site [chemical binding]; other site
243365012585	elongation factor G; Reviewed; Region: PRK00007
243365012586	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
243365012587	G1 box; other site
243365012588	putative GEF interaction site [polypeptide binding]; other site
243365012589	GTP/Mg2+ binding site [chemical binding]; other site
243365012590	Switch I region; other site
243365012591	G2 box; other site
243365012592	G3 box; other site
243365012593	Switch II region; other site
243365012594	G4 box; other site
243365012595	G5 box; other site
243365012596	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
243365012597	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
243365012598	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
243365012599	30S ribosomal protein S7; Validated; Region: PRK05302
243365012600	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
243365012601	S17 interaction site [polypeptide binding]; other site
243365012602	S8 interaction site; other site
243365012603	16S rRNA interaction site [nucleotide binding]; other site
243365012604	streptomycin interaction site [chemical binding]; other site
243365012605	23S rRNA interaction site [nucleotide binding]; other site
243365012606	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
243365012607	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
243365012608	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
243365012609	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
243365012610	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
243365012611	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
243365012612	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
243365012613	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
243365012614	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
243365012615	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
243365012616	DNA binding site [nucleotide binding]
243365012617	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
243365012618	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
243365012619	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
243365012620	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
243365012621	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
243365012622	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
243365012623	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
243365012624	RPB3 interaction site [polypeptide binding]; other site
243365012625	RPB1 interaction site [polypeptide binding]; other site
243365012626	RPB11 interaction site [polypeptide binding]; other site
243365012627	RPB10 interaction site [polypeptide binding]; other site
243365012628	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
243365012629	core dimer interface [polypeptide binding]; other site
243365012630	peripheral dimer interface [polypeptide binding]; other site
243365012631	L10 interface [polypeptide binding]; other site
243365012632	L11 interface [polypeptide binding]; other site
243365012633	putative EF-Tu interaction site [polypeptide binding]; other site
243365012634	putative EF-G interaction site [polypeptide binding]; other site
243365012635	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
243365012636	23S rRNA interface [nucleotide binding]; other site
243365012637	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
243365012638	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
243365012639	mRNA/rRNA interface [nucleotide binding]; other site
243365012640	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
243365012641	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
243365012642	23S rRNA interface [nucleotide binding]; other site
243365012643	L7/L12 interface [polypeptide binding]; other site
243365012644	putative thiostrepton binding site; other site
243365012645	L25 interface [polypeptide binding]; other site
243365012646	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
243365012647	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
243365012648	putative homodimer interface [polypeptide binding]; other site
243365012649	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
243365012650	heterodimer interface [polypeptide binding]; other site
243365012651	homodimer interface [polypeptide binding]; other site
243365012652	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
243365012653	elongation factor Tu; Reviewed; Region: PRK00049
243365012654	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
243365012655	G1 box; other site
243365012656	GEF interaction site [polypeptide binding]; other site
243365012657	GTP/Mg2+ binding site [chemical binding]; other site
243365012658	Switch I region; other site
243365012659	G2 box; other site
243365012660	G3 box; other site
243365012661	Switch II region; other site
243365012662	G4 box; other site
243365012663	G5 box; other site
243365012664	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
243365012665	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
243365012666	Antibiotic Binding Site [chemical binding]; other site
243365012667	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
243365012668	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
243365012669	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365012670	S-adenosylmethionine binding site [chemical binding]; other site
243365012671	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
243365012672	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
243365012673	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
243365012674	P loop; other site
243365012675	GTP binding site [chemical binding]; other site
243365012676	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
243365012677	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
243365012678	Walker A/P-loop; other site
243365012679	ATP binding site [chemical binding]; other site
243365012680	Q-loop/lid; other site
243365012681	ABC transporter signature motif; other site
243365012682	Walker B; other site
243365012683	D-loop; other site
243365012684	H-loop/switch region; other site
243365012685	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
243365012686	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
243365012687	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
243365012688	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
243365012689	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
243365012690	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
243365012691	DNA binding residues [nucleotide binding]
243365012692	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
243365012693	O-Antigen ligase; Region: Wzy_C; pfam04932
243365012694	Domain of unknown function (DUF3366); Region: DUF3366; pfam11846
243365012695	O-Antigen ligase; Region: Wzy_C; pfam04932
243365012696	Domain of unknown function (DUF3366); Region: DUF3366; pfam11846
243365012697	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
243365012698	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
243365012699	Pilin (bacterial filament); Region: Pilin; pfam00114
243365012700	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943
243365012701	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
243365012702	inhibitor-cofactor binding pocket; inhibition site
243365012703	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365012704	catalytic residue [active]
243365012705	gamma-glutamyl kinase; Provisional; Region: PRK05429
243365012706	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
243365012707	nucleotide binding site [chemical binding]; other site
243365012708	homotetrameric interface [polypeptide binding]; other site
243365012709	putative phosphate binding site [ion binding]; other site
243365012710	putative allosteric binding site; other site
243365012711	PUA domain; Region: PUA; pfam01472
243365012712	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
243365012713	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
243365012714	Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042
243365012715	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
243365012716	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243365012717	Walker A motif; other site
243365012718	ATP binding site [chemical binding]; other site
243365012719	Walker B motif; other site
243365012720	arginine finger; other site
243365012721	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
243365012722	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
243365012723	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
243365012724	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
243365012725	Lumazine binding domain; Region: Lum_binding; pfam00677
243365012726	Lumazine binding domain; Region: Lum_binding; pfam00677
243365012727	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
243365012728	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243365012729	dimer interface [polypeptide binding]; other site
243365012730	phosphorylation site [posttranslational modification]
243365012731	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365012732	ATP binding site [chemical binding]; other site
243365012733	Mg2+ binding site [ion binding]; other site
243365012734	G-X-G motif; other site
243365012735	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
243365012736	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365012737	active site
243365012738	phosphorylation site [posttranslational modification]
243365012739	intermolecular recognition site; other site
243365012740	dimerization interface [polypeptide binding]; other site
243365012741	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243365012742	Walker A motif; other site
243365012743	ATP binding site [chemical binding]; other site
243365012744	Walker B motif; other site
243365012745	arginine finger; other site
243365012746	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
243365012747	BON domain; Region: BON; pfam04972
243365012748	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
243365012749	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
243365012750	substrate binding pocket [chemical binding]; other site
243365012751	membrane-bound complex binding site; other site
243365012752	hinge residues; other site
243365012753	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
243365012754	RuvA N terminal domain; Region: RuvA_N; pfam01330
243365012755	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
243365012756	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
243365012757	active site
243365012758	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
243365012759	active site
243365012760	putative DNA-binding cleft [nucleotide binding]; other site
243365012761	dimer interface [polypeptide binding]; other site
243365012762	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
243365012763	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
243365012764	Substrate binding site; other site
243365012765	metal-binding site
243365012766	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
243365012767	Phosphotransferase enzyme family; Region: APH; pfam01636
243365012768	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
243365012769	Organic solvent tolerance protein; Region: OstA_C; pfam04453
243365012770	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
243365012771	SurA N-terminal domain; Region: SurA_N; pfam09312
243365012772	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
243365012773	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
243365012774	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
243365012775	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
243365012776	Repair protein; Region: Repair_PSII; pfam04536
243365012777	Repair protein; Region: Repair_PSII; pfam04536
243365012778	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
243365012779	Protein of unknown function (DUF3683); Region: DUF3683; pfam12447
243365012780	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
243365012781	FAD binding domain; Region: FAD_binding_4; pfam01565
243365012782	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
243365012783	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
243365012784	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
243365012785	Cysteine-rich domain; Region: CCG; pfam02754
243365012786	Cysteine-rich domain; Region: CCG; pfam02754
243365012787	Domain of unknown function (DUF3400); Region: DUF3400; pfam11880
243365012788	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
243365012789	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
243365012790	DNA binding residues [nucleotide binding]
243365012791	drug binding residues [chemical binding]; other site
243365012792	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
243365012793	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365012794	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365012795	metal binding site [ion binding]; metal-binding site
243365012796	active site
243365012797	I-site; other site
243365012798	Isochorismatase family; Region: Isochorismatase; pfam00857
243365012799	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
243365012800	catalytic triad [active]
243365012801	conserved cis-peptide bond; other site
243365012802	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
243365012803	aromatic chitin/cellulose binding site residues [chemical binding]; other site
243365012804	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
243365012805	Glyco_18 domain; Region: Glyco_18; smart00636
243365012806	active site
243365012807	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
243365012808	Domain of unknown function DUF21; Region: DUF21; pfam01595
243365012809	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
243365012810	Transporter associated domain; Region: CorC_HlyC; smart01091
243365012811	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
243365012812	nucleotide binding site/active site [active]
243365012813	HIT family signature motif; other site
243365012814	catalytic residue [active]
243365012815	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
243365012816	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365012817	dimer interface [polypeptide binding]; other site
243365012818	putative CheW interface [polypeptide binding]; other site
243365012819	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
243365012820	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
243365012821	active site residue [active]
243365012822	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
243365012823	active site residue [active]
243365012824	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
243365012825	Serine hydrolase; Region: Ser_hydrolase; pfam06821
243365012826	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
243365012827	putative active site [active]
243365012828	putative catalytic site [active]
243365012829	putative DNA binding site [nucleotide binding]; other site
243365012830	putative phosphate binding site [ion binding]; other site
243365012831	metal binding site A [ion binding]; metal-binding site
243365012832	putative AP binding site [nucleotide binding]; other site
243365012833	putative metal binding site B [ion binding]; other site
243365012834	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
243365012835	active site
243365012836	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
243365012837	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
243365012838	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
243365012839	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
243365012840	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
243365012841	dimerization interface [polypeptide binding]; other site
243365012842	DPS ferroxidase diiron center [ion binding]; other site
243365012843	ion pore; other site
243365012844	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
243365012845	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
243365012846	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
243365012847	active site
243365012848	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
243365012849	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
243365012850	catalytic residues [active]
243365012851	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
243365012852	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
243365012853	ATP binding site [chemical binding]; other site
243365012854	substrate interface [chemical binding]; other site
243365012855	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
243365012856	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
243365012857	active site
243365012858	phosphorylation site [posttranslational modification]
243365012859	intermolecular recognition site; other site
243365012860	dimerization interface [polypeptide binding]; other site
243365012861	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
243365012862	Walker A motif; other site
243365012863	ATP binding site [chemical binding]; other site
243365012864	Walker B motif; other site
243365012865	arginine finger; other site
243365012866	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
243365012867	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
243365012868	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
243365012869	dimerization interface [polypeptide binding]; other site
243365012870	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
243365012871	dimer interface [polypeptide binding]; other site
243365012872	phosphorylation site [posttranslational modification]
243365012873	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
243365012874	ATP binding site [chemical binding]; other site
243365012875	Mg2+ binding site [ion binding]; other site
243365012876	G-X-G motif; other site
243365012877	Domain of unknown function (DUF4390); Region: DUF4390; pfam14334
243365012878	16S rRNA methyltransferase B; Provisional; Region: PRK10901
243365012879	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
243365012880	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365012881	S-adenosylmethionine binding site [chemical binding]; other site
243365012882	M48 family peptidase; Provisional; Region: PRK03001
243365012883	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
243365012884	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
243365012885	putative active site [active]
243365012886	substrate binding site [chemical binding]; other site
243365012887	putative cosubstrate binding site; other site
243365012888	catalytic site [active]
243365012889	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
243365012890	substrate binding site [chemical binding]; other site
243365012891	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
243365012892	active site
243365012893	catalytic residues [active]
243365012894	metal binding site [ion binding]; metal-binding site
243365012895	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
243365012896	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
243365012897	DNA protecting protein DprA; Region: dprA; TIGR00732
243365012898	Protein of unknown function (DUF494); Region: DUF494; pfam04361
243365012899	DNA topoisomerase I; Validated; Region: PRK06599
243365012900	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
243365012901	active site
243365012902	interdomain interaction site; other site
243365012903	putative metal-binding site [ion binding]; other site
243365012904	nucleotide binding site [chemical binding]; other site
243365012905	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
243365012906	domain I; other site
243365012907	DNA binding groove [nucleotide binding]
243365012908	phosphate binding site [ion binding]; other site
243365012909	domain II; other site
243365012910	domain III; other site
243365012911	nucleotide binding site [chemical binding]; other site
243365012912	catalytic site [active]
243365012913	domain IV; other site
243365012914	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
243365012915	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
243365012916	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
243365012917	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
243365012918	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
243365012919	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
243365012920	glutathione synthetase; Provisional; Region: PRK05246
243365012921	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
243365012922	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
243365012923	Glutamate-cysteine ligase; Region: GshA; pfam08886
243365012924	glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049
243365012925	poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938
243365012926	N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964
243365012927	putative active site [active]
243365012928	putative metal binding site [ion binding]; other site
243365012929	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
243365012930	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
243365012931	substrate binding site [chemical binding]; other site
243365012932	ATP binding site [chemical binding]; other site
243365012933	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
243365012934	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
243365012935	catalytic residues [active]
243365012936	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
243365012937	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
243365012938	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
243365012939	SEC-C motif; Region: SEC-C; pfam02810
243365012940	PhoD-like phosphatase; Region: PhoD; pfam09423
243365012941	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
243365012942	putative active site [active]
243365012943	putative metal binding site [ion binding]; other site
243365012944	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
243365012945	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
243365012946	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365012947	dimer interface [polypeptide binding]; other site
243365012948	conserved gate region; other site
243365012949	putative PBP binding loops; other site
243365012950	ABC-ATPase subunit interface; other site
243365012951	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365012952	dimer interface [polypeptide binding]; other site
243365012953	conserved gate region; other site
243365012954	putative PBP binding loops; other site
243365012955	ABC-ATPase subunit interface; other site
243365012956	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
243365012957	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
243365012958	Walker A/P-loop; other site
243365012959	ATP binding site [chemical binding]; other site
243365012960	Q-loop/lid; other site
243365012961	ABC transporter signature motif; other site
243365012962	Walker B; other site
243365012963	D-loop; other site
243365012964	H-loop/switch region; other site
243365012965	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
243365012966	Protein of unknown function (DUF721); Region: DUF721; pfam05258
243365012967	Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511
243365012968	acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397
243365012969	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
243365012970	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
243365012971	Mechanosensitive ion channel; Region: MS_channel; pfam00924
243365012972	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
243365012973	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
243365012974	putative catalytic cysteine [active]
243365012975	Transcriptional regulator [Transcription]; Region: LysR; COG0583
243365012976	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
243365012977	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
243365012978	putative effector binding pocket; other site
243365012979	dimerization interface [polypeptide binding]; other site
243365012980	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
243365012981	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
243365012982	dimer interface [polypeptide binding]; other site
243365012983	active site
243365012984	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365012985	putative substrate translocation pore; other site
243365012986	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
243365012987	thioester reductase domain; Region: Thioester-redct; TIGR01746
243365012988	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
243365012989	putative NAD(P) binding site [chemical binding]; other site
243365012990	active site
243365012991	putative substrate binding site [chemical binding]; other site
243365012992	cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366
243365012993	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
243365012994	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
243365012995	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
243365012996	HAMP domain; Region: HAMP; pfam00672
243365012997	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
243365012998	dimer interface [polypeptide binding]; other site
243365012999	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
243365013000	putative CheW interface [polypeptide binding]; other site
243365013001	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
243365013002	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
243365013003	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
243365013004	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
243365013005	Ligand Binding Site [chemical binding]; other site
243365013006	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
243365013007	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
243365013008	RNA binding surface [nucleotide binding]; other site
243365013009	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
243365013010	BCCT family transporter; Region: BCCT; pfam02028
243365013011	hypothetical protein; Provisional; Region: PRK11239
243365013012	Protein of unknown function, DUF480; Region: DUF480; pfam04337
243365013013	YfaZ precursor; Region: YfaZ; pfam07437
243365013014	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
243365013015	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
243365013016	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
243365013017	active site
243365013018	Zn binding site [ion binding]; other site
243365013019	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
243365013020	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
243365013021	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
243365013022	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
243365013023	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
243365013024	tetramer interface [polypeptide binding]; other site
243365013025	pyridoxal 5'-phosphate binding site [chemical binding]; other site
243365013026	catalytic residue [active]
243365013027	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
243365013028	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
243365013029	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
243365013030	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
243365013031	putative ATP binding site [chemical binding]; other site
243365013032	putative substrate interface [chemical binding]; other site
243365013033	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
243365013034	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
243365013035	CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471
243365013036	multidrug efflux system translocase MdfA; Provisional; Region: PRK15402
243365013037	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
243365013038	Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443
243365013039	Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893
243365013040	Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080
243365013041	putative catalytic cysteine [active]
243365013042	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
243365013043	acyl-activating enzyme (AAE) consensus motif; other site
243365013044	CoA binding site [chemical binding]; other site
243365013045	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
243365013046	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
243365013047	Coenzyme A binding pocket [chemical binding]; other site
243365013048	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
243365013049	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895
243365013050	Protein of unknown function (DUF3224); Region: DUF3224; pfam11528
243365013051	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
243365013052	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
243365013053	Walker A/P-loop; other site
243365013054	ATP binding site [chemical binding]; other site
243365013055	Q-loop/lid; other site
243365013056	ABC transporter signature motif; other site
243365013057	Walker B; other site
243365013058	D-loop; other site
243365013059	H-loop/switch region; other site
243365013060	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
243365013061	oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473
243365013062	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
243365013063	Walker A/P-loop; other site
243365013064	ATP binding site [chemical binding]; other site
243365013065	Q-loop/lid; other site
243365013066	ABC transporter signature motif; other site
243365013067	Walker B; other site
243365013068	D-loop; other site
243365013069	H-loop/switch region; other site
243365013070	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
243365013071	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
243365013072	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
243365013073	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365013074	dimer interface [polypeptide binding]; other site
243365013075	conserved gate region; other site
243365013076	putative PBP binding loops; other site
243365013077	ABC-ATPase subunit interface; other site
243365013078	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
243365013079	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365013080	dimer interface [polypeptide binding]; other site
243365013081	conserved gate region; other site
243365013082	putative PBP binding loops; other site
243365013083	ABC-ATPase subunit interface; other site
243365013084	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
243365013085	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
243365013086	peptide binding site [polypeptide binding]; other site
243365013087	dihydroorotase; Provisional; Region: PRK05451
243365013088	active site
243365013089	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
243365013090	CPxP  motif; other site
243365013091	NRDE protein; Region: NRDE; cl01315
243365013092	CNP1-like family; Region: CNP1; pfam08750
243365013093	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
243365013094	trimer interface [polypeptide binding]; other site
243365013095	dimer interface [polypeptide binding]; other site
243365013096	putative active site [active]
243365013097	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
243365013098	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
243365013099	cell division protein FtsZ; Validated; Region: PRK09330
243365013100	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
243365013101	nucleotide binding site [chemical binding]; other site
243365013102	SulA interaction site; other site
243365013103	cell division protein FtsA; Region: ftsA; TIGR01174
243365013104	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
243365013105	nucleotide binding site [chemical binding]; other site
243365013106	Cell division protein FtsA; Region: FtsA; pfam14450
243365013107	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
243365013108	Cell division protein FtsQ; Region: FtsQ; pfam03799
243365013109	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
243365013110	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
243365013111	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
243365013112	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
243365013113	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
243365013114	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
243365013115	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
243365013116	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
243365013117	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
243365013118	active site
243365013119	homodimer interface [polypeptide binding]; other site
243365013120	cell division protein FtsW; Region: ftsW; TIGR02614
243365013121	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK04308
243365013122	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
243365013123	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
243365013124	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
243365013125	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
243365013126	Mg++ binding site [ion binding]; other site
243365013127	putative catalytic motif [active]
243365013128	putative substrate binding site [chemical binding]; other site
243365013129	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
243365013130	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
243365013131	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
243365013132	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
243365013133	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
243365013134	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
243365013135	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
243365013136	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
243365013137	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
243365013138	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
243365013139	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
243365013140	Cell division protein FtsL; Region: FtsL; pfam04999
243365013141	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
243365013142	MraW methylase family; Region: Methyltransf_5; pfam01795
243365013143	cell division protein MraZ; Reviewed; Region: PRK00326
243365013144	MraZ protein; Region: MraZ; pfam02381
243365013145	MraZ protein; Region: MraZ; pfam02381
243365013146	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
243365013147	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
243365013148	GatB domain; Region: GatB_Yqey; smart00845
243365013149	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
243365013150	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
243365013151	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
243365013152	rod shape-determining protein MreB; Provisional; Region: PRK13927
243365013153	MreB and similar proteins; Region: MreB_like; cd10225
243365013154	nucleotide binding site [chemical binding]; other site
243365013155	Mg binding site [ion binding]; other site
243365013156	putative protofilament interaction site [polypeptide binding]; other site
243365013157	RodZ interaction site [polypeptide binding]; other site
243365013158	rod shape-determining protein MreC; Provisional; Region: PRK13922
243365013159	rod shape-determining protein MreC; Region: MreC; pfam04085
243365013160	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
243365013161	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
243365013162	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
243365013163	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
243365013164	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
243365013165	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
243365013166	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
243365013167	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
243365013168	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
243365013169	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
243365013170	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
243365013171	active site
243365013172	DNA polymerase IV; Validated; Region: PRK02406
243365013173	DNA binding site [nucleotide binding]
243365013174	Protein of unknown function (DUF461); Region: DUF461; pfam04314
243365013175	inner membrane protein; Provisional; Region: PRK10995
243365013176	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
243365013177	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
243365013178	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
243365013179	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
243365013180	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
243365013181	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
243365013182	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
243365013183	Na2 binding site [ion binding]; other site
243365013184	putative substrate binding site 1 [chemical binding]; other site
243365013185	Na binding site 1 [ion binding]; other site
243365013186	putative substrate binding site 2 [chemical binding]; other site
243365013187	aromatic amino acid transporter; Provisional; Region: PRK10238
243365013188	Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470
243365013189	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
243365013190	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
243365013191	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
243365013192	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
243365013193	C-terminal domain interface [polypeptide binding]; other site
243365013194	GSH binding site (G-site) [chemical binding]; other site
243365013195	dimer interface [polypeptide binding]; other site
243365013196	C-terminal, alpha helical domain of an unknown subfamily 9 of Glutathione S-transferases; Region: GST_C_9; cd10424
243365013197	putative N-terminal domain interface [polypeptide binding]; other site
243365013198	putative dimer interface [polypeptide binding]; other site
243365013199	putative substrate binding pocket (H-site) [chemical binding]; other site
243365013200	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
243365013201	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
243365013202	active site
243365013203	nucleophile elbow; other site
243365013204	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
243365013205	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
243365013206	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
243365013207	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365013208	S-adenosylmethionine binding site [chemical binding]; other site
243365013209	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
243365013210	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
243365013211	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
243365013212	S-adenosylmethionine binding site [chemical binding]; other site
243365013213	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
243365013214	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
243365013215	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
243365013216	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
243365013217	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
243365013218	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
243365013219	metal binding site [ion binding]; metal-binding site
243365013220	active site
243365013221	I-site; other site
243365013222	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
243365013223	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
243365013224	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
243365013225	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
243365013226	catalytic residue [active]
243365013227	biotin synthase; Region: bioB; TIGR00433
243365013228	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
243365013229	FeS/SAM binding site; other site
243365013230	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
243365013231	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
243365013232	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
243365013233	active site
243365013234	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
243365013235	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
243365013236	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
243365013237	Sporulation related domain; Region: SPOR; pfam05036
243365013238	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
243365013239	G1 box; other site
243365013240	GTP/Mg2+ binding site [chemical binding]; other site
243365013241	Switch I region; other site
243365013242	G2 box; other site
243365013243	G3 box; other site
243365013244	Switch II region; other site
243365013245	G4 box; other site
243365013246	G5 box; other site
243365013247	Cytochrome c553 [Energy production and conversion]; Region: COG2863
243365013248	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
243365013249	Cytochrome c; Region: Cytochrom_C; cl11414
243365013250	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
243365013251	ResB-like family; Region: ResB; pfam05140
243365013252	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
243365013253	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
243365013254	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
243365013255	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
243365013256	Transporter associated domain; Region: CorC_HlyC; smart01091
243365013257	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
243365013258	putative active site [active]
243365013259	GIY-YIG motif/motif A; other site
243365013260	putative metal binding site [ion binding]; other site
243365013261	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
243365013262	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365013263	dimer interface [polypeptide binding]; other site
243365013264	conserved gate region; other site
243365013265	ABC-ATPase subunit interface; other site
243365013266	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
243365013267	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
243365013268	Walker A/P-loop; other site
243365013269	ATP binding site [chemical binding]; other site
243365013270	Q-loop/lid; other site
243365013271	ABC transporter signature motif; other site
243365013272	Walker B; other site
243365013273	D-loop; other site
243365013274	H-loop/switch region; other site
243365013275	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
243365013276	dimer interface [polypeptide binding]; other site
243365013277	conserved gate region; other site
243365013278	putative PBP binding loops; other site
243365013279	ABC-ATPase subunit interface; other site
243365013280	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
243365013281	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
243365013282	FtsX-like permease family; Region: FtsX; pfam02687
243365013283	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
243365013284	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
243365013285	Walker A/P-loop; other site
243365013286	ATP binding site [chemical binding]; other site
243365013287	Q-loop/lid; other site
243365013288	ABC transporter signature motif; other site
243365013289	Walker B; other site
243365013290	D-loop; other site
243365013291	H-loop/switch region; other site
243365013292	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
243365013293	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
243365013294	HlyD family secretion protein; Region: HlyD_3; pfam13437
243365013295	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
243365013296	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419
243365013297	putative active site [active]
243365013298	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
243365013299	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
243365013300	Walker A/P-loop; other site
243365013301	ATP binding site [chemical binding]; other site
243365013302	Q-loop/lid; other site
243365013303	ABC transporter signature motif; other site
243365013304	Walker B; other site
243365013305	D-loop; other site
243365013306	H-loop/switch region; other site
243365013307	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
243365013308	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
243365013309	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
243365013310	GTP/Mg2+ binding site [chemical binding]; other site
243365013311	G4 box; other site
243365013312	G5 box; other site
243365013313	trmE is a tRNA modification GTPase; Region: trmE; cd04164
243365013314	G1 box; other site
243365013315	G1 box; other site
243365013316	GTP/Mg2+ binding site [chemical binding]; other site
243365013317	Switch I region; other site
243365013318	Switch I region; other site
243365013319	G2 box; other site
243365013320	G2 box; other site
243365013321	Switch II region; other site
243365013322	G3 box; other site
243365013323	G3 box; other site
243365013324	Switch II region; other site
243365013325	G4 box; other site
243365013326	G5 box; other site
243365013327	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
243365013328	membrane protein insertase; Provisional; Region: PRK01318
243365013329	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
243365013330	Haemolytic domain; Region: Haemolytic; pfam01809
243365013331	ribonuclease P; Reviewed; Region: rnpA; PRK04390
243365013332	Ribosomal protein L34; Region: Ribosomal_L34; cl00370